US 9,861,286 B1Grant
Short-wave infrared super-continuum lasers for early detection of dental caries
Issue Date:2018-01-09
•20 Claims
•19 Drawing Sheets
Abstract
A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.
Metadata
Assignee
- Omni Medsci, Inc.
Inventor
- Mohammed N. Islam
Application Information
Application Number:US 15/686,198
Filing Date:2017-08-25
Priority Date:2012-12-31
Art Unit:2886
Classifications
IPC:
G01J3/00A61B5/00G01N33/49G01N33/44G01N33/15G01N33/02G01N21/88G01N21/3563G01N21/359G01J3/453A61B5/145A61B5/1455H01S3/30G01N21/39G01M3/38G01J3/28G01J3/10G01J3/18G01J3/14
Field of Search:
G01J 3/02G01J 3/28G01J 3/42G01N 21/31G01N 21/552
Patent Drawings (19 sheets)
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a Continuation of U.S. application Ser. No. 15/357,136 filed Nov. 21, 2016, which is a Continuation of U.S. application Ser. No. 14/651,367 filed Jun. 11, 2015, which is the U.S. national phase of PCT Application No. PCT/US2013/075736 filed Dec. 17, 2013, which claims the benefit of U.S. provisional application Ser. No. 61/747,477 filed Dec. 31, 2012 and U.S. provisional application Ser. No. 61/754,698 filed Jan. 21, 2013, the disclosures of which are hereby incorporated by reference in their entirety.
[0002] This application is related to U.S. provisional application Ser. No. 61/747,472 filed Dec. 31, 2012; Ser. No. 61/747,481 filed Dec. 31, 2012; Ser. No. 61/747,485 filed Dec. 31, 2012; Ser. No. 61/747,487 filed Dec. 31, 2012; Ser. No. 61/747,492 filed Dec. 31, 2012; and Ser. No. 61/747,553 filed Dec. 31, 2012, the disclosures of which are hereby incorporated in their entirety in their entirety by reference herein.
[0003] This application has a common priority date with commonly owned U.S. application Ser. No. 14/650,897 filed Jun. 10, 2015, which is the U.S. national phase of International Application PCT/US2013/075700 entitled Near-Infrared Lasers For Non-Invasive Monitoring Of Glucose, Ketones, HBA1C, And Other Blood Constituents; U.S. application Ser. No. 14/108,995 filed Dec. 17, 2013, now U.S. Pat. No. 9,164,032 entitled Focused Near-Infrared Lasers For Non-Invasive Vasectomy And Other Thermal Coagulation Or Occlusion Procedures; U.S. application Ser. No. 14/650,981 filed Jun. 10, 2015, which is the U.S. national phase of International Application PCT/US2013/075767 entitled Short-Wave Infrared Super-Continuum Lasers For Natural Gas Leak Detection, Exploration, And Other Active Remote Sensing Applications; U.S. application Ser. No. 14/108,986 filed Dec. 17, 2013 entitled Short-Wave Infrared Super-Continuum Lasers For Detecting Counterfeit Or Illicit Drugs And Pharmaceutical Process Control; U.S. application Ser. No. 14/108,974 filed Dec. 17, 2013 entitled Non-Invasive Treatment Of Varicose Veins; and U.S. application Ser. No. 14/109,007 filed Dec. 17, 2013 entitled Near-Infrared Super-Continuum Lasers For Early Detection Of Breast And Other Cancers, the disclosures of which are hereby incorporated in their entirety by reference herein.
TECHNICAL FIELD
[0004] This disclosure relates to lasers and light sources for healthcare, medical, dental, or bio-technology applications, including systems and methods for using near-infrared or short-wave infrared light sources for early detection of dental caries, often called cavities.
BACKGROUND AND SUMMARY
[0005] Dental care and the prevention of dental decay or dental caries has changed in the United States over the past several decades, due to the introduction of fluoride to drinking water, the use of fluoride dentifrices and rinses, application of topical fluoride in the dental office, and improved dental hygiene. Despite these advances, dental decay continues to be the leading cause of tooth loss. With the improvements over the past several decades, the majority of newly discovered carious lesions tend to be localized to the occlusal pits and fissures of the posterior dentition and the proximal contact sites. These early carious lesions may be often obscured in the complex and convoluted topography of the pits and fissures or may be concealed by debris that frequently accumulates in those regions of the posterior teeth. Moreover, such lesions are difficult to detect in the early stages of development.
[0006] Dental caries may be a dynamic disease that is characterized by tooth demineralization leading to an increase in the porosity of the enamel surface. Leaving these lesions untreated may potentially lead to cavities reaching the dentine and pulp and perhaps eventually causing tooth loss. Occlusal surfaces (bite surfaces) and approximal surfaces (between the teeth) are among the most susceptible sites of demineralization due to acid attack from bacterial by-products in the biofilm. Therefore, there is a need for detection of lesions at an early stage, so that preventive agents may be used to inhibit or reverse the demineralization.
[0007] Traditional methods for caries detection include visual examination and tactile probing with a sharp dental exploration tool, often assisted by radiographic (x-ray) imaging. However, detection using these methods may be somewhat subjective; and, by the time that caries are evident under visual and tactile examination, the disease may have already progressed to an advanced stage. Also, because of the ionizing nature of x-rays, they are dangerous to use (limited use with adults, and even less used with children). Although x-ray methods are suitable for approximal surface lesion detection, they offer reduced utility for screening early caries in occlusal surfaces due to their lack of sensitivity at very early stages of the disease.
[0008] Some of the current imaging methods are based on the observation of the changes of the light transport within the tooth, namely absorption, scattering, transmission, reflection and/or fluorescence of light. Porous media may scatter light more than uniform media. Taking advantage of this effect, the Fiber-optic trans-illumination is a qualitative method used to highlight the lesions within teeth by observing the patterns formed when white light, pumped from one side of the tooth, is scattered away and/or absorbed by the lesion. This technique may be difficult to quantify due to an uneven light distribution inside the tooth.
[0009] Another method called quantitative light-induced fluorescence—QLF—relies on different fluorescence from solid teeth and caries regions when excited with bright light in the visible. For example, when excited by relatively high intensity blue light, healthy tooth enamel yields a higher intensity of fluorescence than does demineralized enamel that has been damaged by caries infection or any other cause. On the other hand, for excitation by relatively high intensity of red light, the opposite magnitude change occurs, since this is the region of the spectrum for which bacteria and bacterial by-products in carious regions absorb and fluoresce more pronouncedly than do healthy areas. However, the image provided by QLF may be difficult to assess due to relatively poor contrast between healthy and infected areas. Moreover, QLF may have difficulty discriminating between white spots and stains because both produce similar effects. Stains on teeth are commonly observed in the occlusal sites of teeth, and this obscures the detection of caries using visible light.
[0010] As described in this disclosure, the near-infrared region of the spectrum offers a novel approach to imaging carious regions because scattering is reduced and absorption by stains is low. For example, it has been demonstrated that the scattering by enamel tissues reduces in the form of 1/(wavelength)3, e.g., inversely as the cube of wavelength. By using a broadband light source in the short-wave infrared (SWIR) part of the spectrum, which corresponds approximately to 1400 nm to 2500 nm, lesions in the enamel and dentine may be observed. In one embodiment, intact teeth have low reflection over the SWIR wavelength range. In the presence of caries, the scattering increases, and the scattering is a function of wavelength; hence, the reflected signal decreases with increasing wavelength. Moreover, particularly when caries exist in the dentine region, water build up may occur, and dips in the SWIR spectrum corresponding to the water absorption lines may be observed. The scattering and water absorption as a function of wavelength may thus be used for early detection of caries and for quantifying the degree of demineralization.
[0011] SWIR light may be generated by light sources such as lamps, light emitting diodes, one or more laser diodes, super-luminescent laser diodes, and fiber-based super-continuum sources. The SWIR super-continuum light sources advantageously may produce high intensity and power, as well as being a nearly transform-limited beam that may also be modulated. Also, apparatuses for caries detection may include C-clamps over teeth, a handheld device with light input and light detection, which may also be attached to other dental equipment such as drills. Alternatively, a mouth-guard type apparatus may be used to simultaneously illuminate one or more teeth. Fiber optics may be conveniently used to guide the light to the patient as well as to transport the signal back to one or more detectors and receivers.
[0012] In one embodiment, a wearable device for use with a smart phone or tablet comprises a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths. At least one of the LEDs emits at a first wavelength having a first penetration depth into tissue and at least another of the LEDs emits at a second wavelength having a second penetration depth into the tissue, wherein at least a portion of the optical beam includes a near-infrared wavelength between 700 nanometers and 2500 nanometers. The measurement device comprises one or more lenses configured to receive and to deliver at least a portion of each of the first and of the second wavelengths to tissue, wherein the tissue reflects at least a portion of each of the first and of the second wavelengths. The measurement device further comprises a receiver configured to capture light while the LEDs are off and convert the captured light into a first signal and capture light while at least one of the LEDs is on and to convert the captured light into a second signal, the captured light including at least a portion of one of the first or second wavelengths reflected from the tissue. The measurement device is configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal. The light source is configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs. The measurement device is further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue.
[0013] In another embodiment, a wearable device for use with a smart phone or tablet comprises a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths, wherein at least a portion of the plurality of optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers. The measurement device comprises one or more lenses configured to receive and to deliver a portion of the optical beam to tissue, wherein the tissue reflects at least a portion of the optical beam delivered to the tissue, and wherein the measurement device is adapted to be placed on a wrist or an ear of a user. The measurement device further comprises a receiver configured to capture light while the LEDs are off and convert the captured light into a first signal and capture light while at least one of the LEDs is on and convert the captured light into a second signal, the captured light including at least a portion of the optical beam reflected from the tissue. The measurement device is configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal. The light source is configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs. The measurement device is further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue.
[0014] In one embodiment, a wearable device for use with a smart phone or tablet comprises a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths, wherein at least a portion of the plurality of optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers. The measurement device comprises one or more lenses configured to receive and to deliver a portion of the optical beam to tissue, wherein the tissue reflects at least a portion of the optical beam delivered to the tissue, and wherein the measurement device is adapted to be placed on a wrist or an ear of a user. The measurement device further comprises a receiver configured to capture light while the LEDs are off and convert the captured light into a first signal and capture light while at least one of the LEDs is on and convert the captured light into a second signal, the captured light including at least a portion of the optical beam reflected from the tissue. The measurement device is configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal. The light source is configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs. The measurement device is further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue. The receiver includes a plurality of spatially separated detectors, wherein at least one analog to digital converter is coupled to the spatially separated detectors.
[0015] In one embodiment, a wearable device for use with a smart phone or tablet includes a measurement device including a light source comprising a plurality of light emitting diodes for measuring one or more physiological parameters, the measurement device configured to generate an input optical beam with one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers. The measurement device comprises one or more lenses configured to receive and to deliver a portion of the input optical beam to a sample comprising skin or tissue, wherein the sample reflects at least a portion of the input optical beam delivered to the sample. The measurement device further comprises a reflective surface configured to receive and redirect at least a portion of light reflected from the sample, and a receiver configured to receive at least a portion of the input optical beam reflected from the sample. The light source is configured to increase a signal-to-noise ratio of the input optical beam reflected from the sample, wherein the increased signal-to-noise ratio results from an increase to the light intensity from at least one of the plurality of light emitting diodes and from modulation of at least one of the plurality of light emitting diodes. The measurement device is configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the sample. The wearable device is configured to communicate with the smart phone or tablet, the smart phone or tablet comprising a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen. The smart phone or tablet is configured to receive and to process at least a portion of the output signal, wherein the smart phone or tablet is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link.
[0016] In another embodiment, a wearable device for use with a smart phone or tablet includes a measurement device including a light source comprising a plurality of light emitting diodes for measuring one or more physiological parameters, the measurement device configured to generate an input optical beam with one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers. The measurement device comprises one or more lenses configured to receive and to deliver a portion of the input optical beam to a sample comprising skin or tissue, wherein the sample reflects at least a portion of the input optical beam delivered to the sample. The measurement device further comprises a reflective surface configured to receive and redirect at least a portion of light reflected from the sample. The measurement device further comprises a receiver configured to receive at least a portion of the input optical beam reflected from the sample, the receiver being located a first distance from a first one of the plurality of light emitting diodes and a different distance from a second one of the plurality of light emitting diodes such that the receiver receives a first signal from the first light emitting diode and a second signal from the second light emitting diode. The measurement device is configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the sample. The wearable device is configured to communicate with the smart phone or tablet. The smart phone or tablet comprises a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen, and is configured to receive and to process at least a portion of the output signal. The smart phone or tablet is configured to store and display the processed output signal, wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link.
[0017] In one embodiment, a method of measuring physiological information comprises providing a wearable device for use with a smart phone or tablet, the smart phone or tablet comprising a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen. The wearable device is capable of performing all of the steps comprising: generating an input optical beam having one or more optical wavelengths using a light source comprising a plurality of light emitting diodes, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers; delivering a portion of the input optical beam to a sample comprising skin or tissue using one or more lenses; receiving and reflecting at least a portion of the input optical beam reflected from the sample; receiving a portion of the input optical beam reflected from the sample to generate an output signal representing at least in part a non-invasive measurement on blood contained within the sample; increasing the signal-to-noise ratio of the input optical beam reflected from the sample by increasing a light intensity from at least one of the plurality of light emitting diodes and by modulating at least one of the plurality of light emitting diodes; and transmitting at least a portion of the output signal to the smart phone or tablet for processing to generate a processed output signal and for transmitting from the smart phone or tablet at least a portion of the processed output signal over a wireless transmission link.
[0018] In another embodiment, a method of measuring physiological information comprises providing a wearable device for use with a smart phone or tablet, the smart phone or tablet comprising a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen. The wearable device is capable of performing all of the steps comprising: generating a first and a second input optical beam each having one or more optical wavelengths using a light source comprising a plurality of light emitting diodes, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers; delivering a portion of the first input optical beam and a portion of the second input optical beam to a sample comprising skin or tissue using one or more lenses; receiving and reflecting at least a portion of the input optical beam reflected from the sample; receiving a portion of the first input optical beam reflected from the sample from a first one of the plurality of light emitting diodes located at a first distance and receiving a portion of the second input optical beam reflected from the sample from a different one of the plurality of light emitting diodes located at a distance different from the first distance to generate an output signal representing at least in part a non-invasive measurement on blood contained within the sample; and transmitting at least a portion of the output signal to the smart phone or tablet for processing to generate a processed output signal and for transmitting from the smart phone or tablet at least a portion of the processed output signal over a wireless transmission link.
BRIEF DESCRIPTION OF THE DRAWINGS
[0019] For a more complete understanding of the present disclosure, and for further features and advantages thereof, reference is now made to the following description taken in conjunction with the accompanying drawings, in which:
[0020] FIG. 1 illustrates the structure of a tooth.
[0021] FIG. 2A shows the attenuation coefficient for dental enamel and water versus wavelength from approximately 600 nm to 2600 nm.
[0022] FIG. 2B illustrates the absorption spectrum of intact enamel and dentine in the wavelength range of approximately 1.2 to 2.4 microns.
[0023] FIG. 3 shows the near infrared spectral reflectance over the wavelength range of approximately 800 nm to 2500 nm from an occlusal tooth surface. The black diamonds correspond to the reflectance from a sound, intact tooth section. The asterisks correspond to a tooth section with an enamel lesion. The circles correspond to a tooth section with a dentine lesion.
[0024] FIG. 4 illustrates a hand-held dental tool design of a human interface that may also be coupled with other dental tools.
[0025] FIG. 5A illustrates a clamp design of a human interface to cap over one or more teeth and perform a non-invasive measurement for dental caries.
[0026] FIG. 5B shows a mouth guard design of a human interface to perform a non-invasive measurement for dental caries.
[0027] FIG. 6A illustrates the dorsal of a hand for performing a differential measurement for measuring blood constituents or analytes.
[0028] FIG. 6B illustrates the dorsal of a foot for performing a differential measurement for measuring blood constituents or analytes.
[0029] FIG. 7 illustrates a block diagram or building blocks for constructing high power laser diode assemblies.
[0030] FIG. 8 shows a platform architecture for different wavelength ranges for an all-fiber-integrated, high powered, super-continuum light source.
[0031] FIG. 9 illustrates one embodiment for a short-wave infrared super-continuum light source.
[0032] FIG. 10 shows the output spectrum from the SWIR SC laser of FIG. 9 when about 10 m length of fiber for SC generation is used. This fiber is a single-mode, non-dispersion shifted fiber that is optimized for operation near 1550 nm.
[0033] FIG. 11A illustrates a schematic of the experimental set-up for measuring the diffuse reflectance spectroscopy using the SWIR-SC light source of FIGS. 9 and 10 .
[0034] FIG. 11B shows exemplary reflectance from a sound enamel region, an enamel lesion region, and a dentine lesion region. The spectra are normalized to have equal value near 2050 nm.
[0035] FIGS. 12A-B illustrate high power SWIR-SC lasers that may generate light between approximately 1.4-1.8 microns (FIG. 12A ) or approximately 2-2.5 microns (FIG. 12B ).
[0036] FIG. 12C shows a reflection-spectroscopy based stand-off detection system having an SC laser source.
[0037] FIG. 13 schematically shows that the medical measurement device can be part of a personal or body area network that communicates with another device (e.g., smart phone or tablet) that communicates with the cloud. The cloud may in turn communicate information with the user, dental or healthcare providers, or other designated recipients.
DETAILED DESCRIPTION OF EXAMPLE EMBODIMENTS
[0038] As required, detailed embodiments of the present disclosure are disclosed herein; however, it is to be understood that the disclosed embodiments are merely exemplary of the disclosure that may be embodied in various and alternative forms. The figures are not necessarily to scale; some features may be exaggerated or minimized to show details of particular components. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a representative basis for teaching one skilled in the art to variously employ the present disclosure.
[0039] Near-infrared (NIR) and SWIR light may be preferred for caries detection compared to visible light imaging because the NIR/SWIR wavelengths generally have lower absorption by stains and deeper penetration into teeth. Hence, NIR/SWIR light may provide a caries detection method that can be non-invasive, non-contact and relatively stain insensitive. Broadband light may provide further advantages because carious regions may demonstrate spectral signatures from water absorption and the wavelength dependence of porosity in the scattering of light.
[0040] The wavelength of light should be selected appropriately to achieve a non-invasive procedure. For example, the light should be able to penetrate deep enough to reach through the dermis and subcutaneous fat layers to reach varicose veins. For example, the penetration depth may be defined as the inverse of the absorption coefficient, although it may also be necessary to include the scattering for the calculation. To achieve penetration deep enough to reach the varicose veins, wavelengths may correspond to local minima in water 501 and adipose 502 absorption, as well as potentially local minima in collagen 503 and elastin 504 absorption. For example, wavelengths near approximately 1100 nm, 1310 nm, or 1650 nm may be advantageous for non-invasive procedures. More generally, wavelength ranges of approximately 900 nm to 1150 nm, 1280 nm to 1340 nm, or 1550 nm to 1680 nm may be advantageous for non-invasive procedures.
[0041] In general, the near-infrared region of the electromagnetic spectrum covers between approximately 0.7 microns (700 nm) to about 2.5 microns (2500 nm). However, it may also be advantageous to use just the short-wave infrared between approximately 1.4 microns (1400 nm) and about 2.5 microns (2500 nm). One reason for preferring the SWIR over the entire NIR may be to operate in the so-called “eye safe” window, which corresponds to wavelengths longer than about 1400 nm. Therefore, for the remainder of the disclosure the SWIR will be used for illustrative purposes. However, it should be clear that the discussion that follows could also apply to using the NIR wavelength range, or other wavelength bands.
[0042] In particular, wavelengths in the eye safe window may not transmit down to the retina of the eye, and therefore, these wavelengths may be less likely to create permanent eye damage from inadvertent exposure. The near-infrared wavelengths have the potential to be dangerous, because the eye cannot see the wavelengths (as it can in the visible), yet they can penetrate and cause damage to the eye. Even if a practitioner is not looking directly at the laser beam, the practitioner's eyes may receive stray light from a reflection or scattering from some surface. Hence, it can always be a good practice to use eye protection when working around lasers. Since wavelengths longer than about 1400 nm are substantially not transmitted to the retina or substantially absorbed in the retina, this wavelength range is known as the eye safe window. For wavelengths longer than 1400 nm, in general only the cornea of the eye may receive or absorb the light radiation.
[0043] FIG. 1 illustrates the structure of an exemplary cross-section of a tooth 100. The tooth 100 has a top layer called the crown 101 and below that a root 102 that reaches well into the gum 106 and bone 108 of the mouth. The exterior of the crown 101 is an enamel layer 103, and below the enamel is a layer of dentine 104 that sits atop a layer of cementum 107. Below the dentine 104 is a pulp region 105, which comprises within it blood vessels 109 and nerves 110. If the light can penetrate the enamel 103 and dentine 104, then the blood flow and blood constituents may be measured through the blood vessels in the dental pulp 105. While the amount of blood flow in the capillaries of the dental pulp 105 may be less than an artery or vein, the smaller blood flow could still be advantageous for detecting or measuring blood constituents as compared to detection through the skin if there is less interfering spectral features from the tooth. Although the structure of a molar tooth is illustrated in FIG. 1 , other types of teeth also have similar structure. For example, different types of teeth include molars, pre-molars, canine and incisor teeth.
[0044] As used throughout this document, the term “couple” and or “coupled” refers to any direct or indirect communication between two or more elements, whether or not those elements are physically connected to one another. As used throughout this disclosure, the term “spectroscopy” means that a tissue or sample is inspected by comparing different features, such as wavelength (or frequency), spatial location, transmission, absorption, reflectivity, scattering, refractive index, or opacity. In one embodiment, “spectroscopy” may mean that the wavelength of the light source is varied, and the transmission, absorption, or reflectivity of the tissue or sample is measured as a function of wavelength. In another embodiment, “spectroscopy” may mean that the wavelength dependence of the transmission, absorption or reflectivity is compared between different spatial locations on a tissue or sample. As an illustration, the “spectroscopy” may be performed by varying the wavelength of the light source, or by using a broadband light source and analyzing the signal using a spectrometer, wavemeter, or optical spectrum analyzer.
[0045] As used throughout this disclosure, the term “fiber laser” refers to a laser or oscillator that has as an output light or an optical beam, wherein at least a part of the laser comprises an optical fiber. For instance, the fiber in the “fiber laser” may comprise one of or a combination of a single mode fiber, a multi-mode fiber, a mid-infrared fiber, a photonic crystal fiber, a doped fiber, a gain fiber, or, more generally, an approximately cylindrically shaped waveguide or light-pipe. In one embodiment, the gain fiber may be doped with rare earth material, such as ytterbium, erbium, and/or thulium, for example. In another embodiment, the mid-infrared fiber may comprise one or a combination of fluoride fiber, ZBLAN fiber, chalcogenide fiber, tellurite fiber, or germanium doped fiber. In yet another embodiment, the single mode fiber may include standard single-mode fiber, dispersion shifted fiber, non-zero dispersion shifted fiber, high-nonlinearity fiber, and small core size fibers.
[0046] As used throughout this disclosure, the term “pump laser” refers to a laser or oscillator that has as an output light or an optical beam, wherein the output light or optical beam is coupled to a gain medium to excite the gain medium, which in turn may amplify another input optical signal or beam. In one particular example, the gain medium may be a doped fiber, such as a fiber doped with ytterbium, erbium, and/or thulium. In one embodiment, the “pump laser” may be a fiber laser, a solid state laser, a laser involving a nonlinear crystal, an optical parametric oscillator, a semiconductor laser, or a plurality of semiconductor lasers that may be multiplexed together. In another embodiment, the “pump laser” may be coupled to the gain medium by using a fiber coupler, a dichroic mirror, a multiplexer, a wavelength division multiplexer, a grating, or a fused fiber coupler.
[0047] As used throughout this document, the term “super-continuum” and or “supercontinuum” and or “SC” refers to a broadband light beam or output that comprises a plurality of wavelengths. In a particular example, the plurality of wavelengths may be adjacent to one-another, so that the spectrum of the light beam or output appears as a continuous band when measured with a spectrometer. In one embodiment, the broadband light beam may have a bandwidth or at least 10 nm. In another embodiment, the “super-continuum” may be generated through nonlinear optical interactions in a medium, such as an optical fiber or nonlinear crystal. For example, the “super-continuum” may be generated through one or a combination of nonlinear activities such as four-wave mixing, the Raman effect, modulational instability, and self-phase modulation.
[0048] As used throughout this disclosure, the terms “optical light” and or “optical beam” and or “light beam” refer to photons or light transmitted to a particular location in space. The “optical light” and or “optical beam” and or “light beam” may be modulated or unmodulated, which also means that they may or may not contain information. In one embodiment, the “optical light” and or “optical beam” and or “light beam” may originate from a fiber, a fiber laser, a laser, a light emitting diode, a lamp, a pump laser, or a light source.
Transmission or Reflection Through Teeth
[0049] The transmission, absorption and reflection from teeth has been studied in the near infrared, and, although there are some features, the enamel and dentine appear to be fairly transparent in the near infrared (particularly SWIR wavelengths between about 1400 and 2500 nm). For example, the absorption or extinction ratio for light transmission has been studied. FIG. 2A illustrates the attenuation coefficient 200 for dental enamel 201 (filled circles) and the absorption coefficient of water 202 (open circles) versus wavelength. Near-infrared light may penetrate much further without scattering through all the tooth enamel, due to the reduced scattering coefficient in normal enamel. Scattering in enamel may be fairly strong in the visible, but decreases as approximately 1/(wavelength)3 [i.e., inverse of the cube of the wavelength] with increasing wavelength to a value of only 2-3 cm-1 at 1310 nm and 1550 nm in the near infrared. Therefore, enamel may be virtually transparent in the near infrared with optical attenuation 1-2 orders of magnitude less than in the visible range.
[0050] As another example, FIG. 2B illustrates the absorption spectrum 250 of intact enamel 251 (dashed line) and dentine 252 (solid line) in the wavelength range of approximately 1.2 to 2.4 microns. In the near infrared there are two absorption bands in the areas of about 1.5 and 2 microns. The band with a peak around 1.57 microns may be attributed to the overtone of valent vibration of water present in both enamel and dentine. In this band, the absorption is greater for dentine than for enamel, which may be related to the large water content in this tissue. In the region of 2 microns, dentine may have two absorption bands, and enamel one. The band with a maximum near 2.1 microns may belong to the overtone of vibration of PO hydroxyapatite groups, which is the main substance of both enamel and dentine. Moreover, the band with a peak near 1.96 microns in dentine may correspond to water absorption (dentine may contain substantially higher water than enamel).
[0051] In addition to the absorption coefficient, the reflectance from intact teeth and teeth with dental caries (e.g., cavities) has been studied. In one embodiment, FIG. 3 shows the near infrared spectral reflectance 300 over the wavelength range of approximately 800 nm to 2500 nm from an occlusal (e.g., top) tooth surface 304. The curve with black diamonds 301 corresponds to the reflectance from a sound, intact tooth section. The curve with asterisks (*) 302 corresponds to a tooth section with an enamel lesion. The curve with circles 303 corresponds to a tooth section with a dentine lesion. Thus, when there is a lesion, more scattering occurs and there may be an increase in the reflected light.
[0052] For wavelengths shorter than approximately 1400 nm, the shapes of the spectra remain similar, but the amplitude of the reflection changes with lesions. Between approximately 1400 nm and 2500 nm, an intact tooth 301 has low reflectance (e.g., high transmission), and the reflectance appears to be more or less independent of wavelength. On the other hand, in the presence of lesions 302 and 303, there is increased scattering, and the scattering loss may be wavelength dependent. For example, the scattering loss may decrease as the inverse of some power of wavelength, such as 1/(wavelength)3—so, the scattering loss decreases with longer wavelengths. When there is a lesion in the dentine 303, more water can accumulate in the area, so there is also increased water absorption. For example, the dips near 1450 nm and 1900 nm may correspond to water absorption, and the reflectance dips are particularly pronounced in the dentine lesion 303.
[0053] FIG. 3 may point to several novel techniques for early detection and quantification of carious regions. One method may be to use a relatively narrow wavelength range (for example, from a laser diode or super-luminescent laser diode) in the wavelength window below 1400 nm. In one embodiment, wavelengths in the vicinity of 1310 nm may be used, which is a standard telecommunications wavelength where appropriate light sources are available. Also, it may be advantageous to use a super-luminescent laser diode rather than a laser diode, because the broader bandwidth may avoid the production of laser speckle that can produce interference patterns due to light's scattering after striking irregular surfaces. As FIG. 3 shows, the amplitude of the reflected light (which may also be proportional to the inverse of the transmission) may increase with dental caries. Hence, comparing the reflected light from a known intact region with a suspect region may help identify carious regions. However, one difficulty with using a relatively narrow wavelength range and relying on amplitude changes may be the calibration of the measurement. For example, the amplitude of the reflected light may depend on many factors, such as irregularities in the dental surface, placement of the light source and detector, distance of the measurement instrument from the tooth, etc.
[0054] In one embodiment, use of a plurality of wavelengths can help to better calibrate the dental caries measurement. For example, a plurality of laser diodes or super-luminescent laser diodes may be used at different center wavelengths. Alternately, a lamp or alternate broadband light source may be used followed by appropriate filters, which may be placed after the light source or before the detectors. In one example, wavelengths near 1090 nm, 1440 nm and 1610 nm may be employed. The reflection from the tooth 305 appears to reach a local maximum near 1090 nm in the representative embodiment illustrated. Also, the reflectance near 1440 nm 306 is higher for dental caries, with a distinct dip particularly for dentine caries 303. Near 1610 nm 307, the reflection is also higher for carious regions. By using a plurality of wavelengths, the values at different wavelengths may help quantify a caries score. In one embodiment, the degree of enamel lesions may be proportional to the ratio of the reflectance near 1610 nm divided by the reflectance near 1090 nm. Also, the degree of dentine lesion may be proportional to the difference between the reflectance near 1610 nm and 1440 nm, with the difference then divided by the reflectance near 1090 nm. Although one set of wavelengths has been described, other wavelengths may also be used and are intended to be covered by this disclosure.
[0055] In yet another embodiment, it may be further advantageous to use all of some fraction of the SWIR between approximately 1400 and 2500 nm. For example, a SWIR super-continuum light source could be used, or a lamp source could be used. On the receiver side, a spectrometer and/or dispersive element could be used to discriminate the various wavelengths. As FIG. 3 shows, an intact tooth 301 has a relatively low and featureless reflectance over the SWIR. On the other hand, with a carious region there is more scattering, so the reflectance 302,303 increases in amplitude. Since the scattering is inversely proportional to wavelength or some power of wavelength, the carious region reflectance 302, 303 also decreases with increasing wavelength. Moreover, the carious region may contain more water, so there are dips in the reflectance near the water absorption lines 306 and 308. The degree of caries or caries score may be quantified by the shape of the spectrum over the SWIR, taking ratios of different parts of the spectrum, or some combination of this and other spectral processing methods.
[0056] Although several methods of early caries detection using spectral reflectance have been described, other techniques could also be used and are intended to be covered by this disclosure. For example, transmittance may be used rather than reflectance, or a combination of the two could be used. Moreover, the transmittance, reflectance and/or absorbance could also be combined with other techniques, such as quantitative light-induced fluorescence or fiber-optic trans-illumination. Also, the SWIR could be advantageous, but other parts of the infrared, near-infrared or visible wavelengths may also be used consistent with this disclosure.
[0057] One other benefit of the absorption, transmission or reflectance in the near infrared and SWIR may be that stains and non-calcified plaque are not visible in this wavelength range, enabling better discrimination of defects, cracks, and demineralized areas. For example, dental calculus, accumulated plaque, and organic stains and debris may interfere significantly with visual diagnosis and fluorescence-based caries detection schemes in occlusal surfaces. In the case of using quantitative light-induced fluorescence, such confounding factors typically may need to be removed by prophylaxis (abrasive cleaning) before reliable measurements can be taken. Surface staining at visible wavelengths may further complicate the problem, and it may be difficult to determine whether pits and fissures are simply stained or demineralized. On the other hand, staining and pigmentation generally interfere less with NIR or SWIR imaging. For example, NIR and SWIR light may not be absorbed by melanin and porphyrins produced by bacteria and those found in food dyes that accumulate in dental plaque and are responsible for the pigmentation.
Human Interface for Measurement System
[0058] A number of different types of measurements may be used to image for dental caries, particularly early detection of dental caries. A basic feature of the measurements may be that the optical properties are measured as a function of wavelength at a plurality of wavelengths. As further described below, the light source may output a plurality of wavelengths, or a continuous spectrum over a range of wavelengths. In one embodiment, the light source may cover some or all of the wavelength range between approximately 1400 nm and 2500 nm. The signal may be received at a receiver, which may also comprise a spectrometer or filters to discriminate between different wavelengths. The signal may also be received at a camera, which may also comprise filters or a spectrometer. In one embodiment, the spectral discrimination using filters or a spectrometer may be placed after the light source rather than at the receiver. The receiver usually comprises one or more detectors (optical-to-electrical conversion element) and electrical circuitry. The receiver may also be coupled to analog to digital converters, particularly if the signal is to be fed to a digital device.
[0059] Referring to FIG. 1 , one or more light sources 111 may be used for illumination. In one embodiment, a transmission measurement may be performed by directing the light source output 111 to the region near the interface between the gum 106 and dentine 104. In one embodiment, the light may be directed using a light guide or a fiber optic. The light may then propagate through the dental pulp 105 to the other side, where the light may be incident on one or more detectors or another light guide to transport the signal to 112 a spectrometer, receiver, and/or camera, for example. In one embodiment, the light source may be directed to one or more locations near the interface between the gum 106 and dentine 104 (in one example, could be from the two sides of the tooth). The transmitted light may then be detected in the occlusal surface above the tooth using a 112 spectrometer, receiver, or camera, for example. In another embodiment, a reflectance measurement may be conducted by directing the light source output 111 to, for example, the occlusal surface of the tooth, and then detecting the reflectance at a 113 spectrometer, receiver or camera. Although a few embodiments for imaging the tooth are described, other embodiments and techniques may also be used and are intended to be covered by this disclosure. These optical techniques may measure optical properties such as reflectance, transmittance, absorption, or luminescence.
[0060] In one embodiment, FIG. 4 shows that the light source and/or detection system may be integrated with a dental hand-piece 400. The hand-piece 400 may also include other dental equipment, such as a drill, pick, air spray or water cooling stream. The dental hand-piece 400 may include a housing 401 and a motor housing 402 (in some embodiments such as with a drill, a motor may be placed in this section). The end of hand-piece 403 that interfaces with the tooth may be detachable, and it may also have the light input and output end. The dental hand-piece 400 may also have an umbilical cord 404 for connecting to power supplies, diagnostics, or other equipment, for example.
[0061] A light guide 405 may be integrated with the hand-piece 400, either inside the housing 401, 402 or adjacent to the housing. In one embodiment, a light source 410 may be contained within the housing 401, 402. In an alternative embodiment, the hand-piece 400 may have a coupler 410 to couple to an external light source 411 and/or detection system or receiver 412. The light source 411 may be coupled to the hand-piece 400 using a light guide or fiber optic cable 406. In addition, the detection system or receiver 412 may be coupled to the hand-piece 400 using one or more light guides, fiber optic cable or a bundle of fibers 407.
[0062] The light incident on the tooth may exit the hand-piece 400 through the end 403. The end 403 may also have a lens system or curved mirror system to collimate or focus the light. In one embodiment, if the light source is integrated with a tool such as a drill, then the light may reach the tooth at the same point as the tip of the drill. The reflected or transmitted light from the tooth may then be observed externally and/or guided back through the light guide 405 in the hand-piece 400. If observed externally, there may be a lens system 408 for collecting the light and a detection system 409 that may have one or more detectors and electronics. If the light is to be guided back through the hand-piece 400, then the reflected light may transmit through the light guide 405 back to the detection system or receiver 412. In one embodiment, the incident light may be guided by a fiber optic through the light guide 405, and the reflected light may be captured by a series of fibers forming a bundle adjacent to or surrounding the incident light fiber.
[0063] In another embodiment, a “clamp” design 500 may be used as a cap over one or more teeth, as illustrated in FIG. 5A . The clamp design may be different for different types of teeth, or it may be flexible enough to fit over different types of teeth. For example, different types of teeth include the molars (toward the back of the mouth), the premolars, the canine, and the incisors (toward the front of the mouth). One embodiment of the clamp-type design is illustrated in FIG. 5A for a molar tooth 508. The C-clamp 501 may be made of a plastic or rubber material, and it may comprise a light source input 502 and a detector output 503 on the front or back of the tooth, for example.
[0064] The light source input 502 may comprise a light source directly, or it may have light guided to it from an external light source. Also, the light source input 502 may comprise a lens system to collimate or focus the light across the tooth. The detector output 503 may comprise a detector directly, or it may have a light guide to transport the signal to an external detector element. The light source input 502 may be coupled electrically or optically through 504 to a light input 506. For example, if the light source is external in 506, then the coupling element 504 may be a light guide, such as a fiber optic. Alternately, if the light source is contained in 502, then the coupling element 504 may be electrical wires connecting to a power supply in 506. Similarly, the detector output 503 may be coupled to a detector output unit 507 with a coupling element 505, which may be one or more electrical wires or a light guide, such as a fiber optic. This is just one example of a clamp over one or more teeth, but other embodiments may also be used and are intended to be covered by this disclosure. For example, if reflectance from the teeth is to be used in the measurement, then the light input 502 and detected light input 503 may be on the same side of the tooth.
[0065] In yet another embodiment, one or more light source ports and sensor ports may be used in a mouth-guard type design. For example, one embodiment of a dental mouth guard 550 is illustrated in FIG. 5B . The structure of the mouth guard 551 may be similar to mouth guards used in sports (e.g., when playing football or boxing) or in dental trays used for applying fluoride treatment, and the mouth guard may be made from plastic, rubber, or any other suitable materials. As an example, the mouth guard may have one or more light source input ports 552, 553 and one or more detector output ports 554, 555. Although six input and output ports are illustrated, any number of ports may be used.
[0066] Similar to the clamp design described above, the light source inputs 552, 553 may comprise one or more light sources directly, or they may have light guided to them from an external light source. Also, the light source inputs 552, 553 may comprise lens systems to collimate or focus the light across the teeth. The detector outputs 554, 555 may comprise one or more detectors directly, or they may have one or more light guides to transport the signals to an external detector element. The light source inputs 552, 553 may be coupled electrically or optically through 556 to a light input 557. For example, if the light source is external in 557, then the one or more coupling elements 556 may be one or more light guides, such as a fiber optic. Alternately, if the light sources are contained in 552, 553, then the coupling element 556 may be one or more electrical wires connecting to a power supply in 557. Similarly, the detector outputs 554, 555 may be coupled to a detector output unit 559 with one or more coupling elements 558, which may be one or more electrical wires or one or more light guides, such as a fiber optic. This is just one example of a mouth guard design covering a plurality of teeth, but other embodiments may also be used and are intended to be covered by this disclosure. For instance, the position of the light source inputs and detector output ports could be exchanged, or some mixture of locations of light source inputs and detector output ports could be used. Also, if reflectance from the teeth is to be measured, then the light sources and detectors may be on the same side of the tooth. Moreover, it may be advantageous to pulse the light source with a particular pulse width and pulse repetition rate, and then the detection system can measure the pulsed light returned from or transmitted through the tooth. Using a lock-in type technique (e.g., detecting at the same frequency as the pulsed light source and also possibly phase locked to the same signal), the detection system may be able to reject background or spurious signals and increase the signal-to-noise ratio of the measurement.
[0067] Other elements may be added to the human interface designs of FIGS. 4-6 and are also intended to be covered by this disclosure. For instance, in one embodiment it may be desirable to have replaceable inserts that may be disposable. Particularly in a dentist's or doctor's office or hospital setting, the same instrument may be used with a plurality of patients. Rather than disinfecting the human interface after each use, it may be preferable to have disposable inserts that can be thrown away after each use. In one embodiment, a thin plastic coating material may enclose the clamp design of FIG. 5A or mouth guard design of FIG. 5B . The coating material may be inserted before each use, and then after the measurement is exercised the coating material may be peeled off and replaced. The coating or covering material may be selected based on suitable optical properties that do not affect the measurement, or known optical properties that can be calibrated or compensated for during measurement. Such a design may save the dentist or physician or user considerable time, while at the same time provide the business venture with a recurring cost revenue source.
[0068] Thus, beyond the problem of other blood constituents or analytes having overlapping spectral features, it may be difficult to observe glucose spectral signatures through the skin and its constituents of water, adipose, collagen and elastin. One approach to overcoming this difficulty may be to try to measure the blood constituents in veins that are located at relatively shallow distances below the skin. Veins may be more beneficial for the measurement than arteries, since arteries tend to be located at deeper levels below the skin. Also, in one embodiment it may be advantageous to use a differential measurement to subtract out some of the interfering absorption lines from the skin. For example, an instrument head may be designed to place one probe above a region of skin over a blood vein, while a second probe may be placed at a region of the skin without a noticeable blood vein below it. Then, by differencing the signals from the two probes, at least part of the skin interference may be cancelled out.
[0069] Two representative embodiments for performing such a differential measurement are illustrated in FIG. 6A and FIG. 6B . In one embodiment shown in FIG. 6A , the dorsal of the hand 600 may be used for measuring blood constituents or analytes. The dorsal of the hand 600 may have regions that have distinct veins 601 as well as regions where the veins are not as shallow or pronounced 602. By stretching the hand and leaning it backwards, the veins 601 may be accentuated in some cases. A near-infrared diffuse reflectance measurement may be performed by placing one probe 603 above the vein-rich region 601. To turn this into a differential measurement, a second probe 604 may be placed above a region without distinct veins 602. Then, the outputs from the two probes may be subtracted 605 to at least partially cancel out the features from the skin. The subtraction may be done preferably in the electrical domain, although it can also be performed in the optical domain or digitally/mathematically using sampled data based on the electrical and/or optical signals. Although one example of using the dorsal of the hand 600 is shown, many other parts of the hand can be used within the scope of this disclosure. For example, alternate methods may use transmission through the webbing between the thumb and the fingers 606, or transmission or diffuse reflection through the tips of the fingers 607.
[0070] In another embodiment, the dorsal of the foot 650 may be used instead of the hand. One advantage of such a configuration may be that for self-testing by a user, the foot may be easier to position the instrument using both hands. One probe 653 may be placed over regions where there are more distinct veins 651, and a near-infrared diffuse reflectance measurement may be made. For a differential measurement, a second probe 654 may be placed over a region with less prominent veins 652, and then the two probe signals may be subtracted, either electronically or optically, or may be digitized/sampled and processed mathematically depending on the particular application and implementation. As with the hand, the differential measurements may be intended to compensate for or subtract out (at least in part) the interference from the skin. Since two regions are used in close proximity on the same body part, this may also aid in removing some variability in the skin from environmental effects such as temperature, humidity, or pressure. In addition, it may be advantageous to first treat the skin before the measurement, by perhaps wiping with a cloth or treated cotton ball, applying some sort of cream, or placing an ice cube or chilled bag over the region of interest.
[0071] Although two embodiments have been described, many other locations on the body may be used using a single or differential probe within the scope of this disclosure. In yet another embodiment, the wrist may be advantageously used, particularly where a pulse rate is typically monitored. Since the pulse may be easily felt on the wrist, there is underlying the region a distinct blood flow. Other embodiments may use other parts of the body, such as the ear lobes, the tongue, the inner lip, the nails, the eye, or the teeth. Some of these embodiments will be further described below. The ear lobes or the tip of the tongue may be advantageous because they are thinner skin regions, thus permitting transmission rather than diffuse reflection. However, the interference from the skin is still a problem in these embodiments. Other regions such as the inner lip or the bottom of the tongue may be contemplated because distinct veins are observable, but still the interference from the skin may be problematic in these embodiments. The eye may seem as a viable alternative because it is more transparent than skin. However, there are still issues with scattering in the eye. For example, the anterior chamber of the eye (the space between the cornea and the iris) comprises a fluid known as aqueous humor. However, the glucose level in the eye chamber may have a significant temporal lag on changes in the glucose level compared to the blood glucose level.
Light Sources for Near Infrared
[0072] There are a number of light sources that may be used in the near infrared. To be more specific, the discussion below will consider light sources operating in the short wave infrared (SWIR), which may cover the wavelength range of approximately 1400 nm to 2500 nm. Other wavelength ranges may also be used for the applications described in this disclosure, so the discussion below is merely provided as exemplary types of light sources. The SWIR wavelength range may be valuable for a number of reasons. First, the SWIR corresponds to a transmission window through water and the atmosphere. Second, the so-called “eye-safe” wavelengths are wavelengths longer than approximately 1400 nm. Third, the SWIR covers the wavelength range for nonlinear combinations of stretching and bending modes as well as the first overtone of C-H stretching modes. Thus, for example, glucose and ketones among other substances may have unique signatures in the SWIR. Moreover, many solids have distinct spectral signatures in the SWIR, so particular solids may be identified using stand-off detection or remote sensing. For instance, many explosives have unique signatures in the SWIR.
[0073] Different light sources may be selected for the SWIR based on the needs of the application. Some of the features for selecting a particular light source include power or intensity, wavelength range or bandwidth, spatial or temporal coherence, spatial beam quality for focusing or transmission over long distance, and pulse width or pulse repetition rate. Depending on the application, lamps, light emitting diodes (LEDs), laser diodes (LD's), tunable LD's, super-luminescent laser diodes (SLDs), fiber lasers or super-continuum sources (SC) may be advantageously used. Also, different fibers may be used for transporting the light, such as fused silica fibers, plastic fibers, mid-infrared fibers (e.g., tellurite, chalcogenides, fluorides, ZBLAN, etc), or a hybrid of these fibers.
[0074] Lamps may be used if low power or intensity of light is required in the SWIR, and if an incoherent beam is suitable. In one embodiment, in the SWIR an incandescent lamp that can be used is based on tungsten and halogen, which have an emission wavelength between approximately 500 nm to 2500 nm. For low intensity applications, it may also be possible to use thermal sources, where the SWIR radiation is based on the black body radiation from the hot object. Although the thermal and lamp based sources are broadband and have low intensity fluctuations, it may be difficult to achieve a high signal-to-noise ratio due to the low power levels. Also, the lamp based sources tend to be energy inefficient.
[0075] In another embodiment, LED's can be used that have a higher power level in the SWIR wavelength range. LED's also produce an incoherent beam, but the power level can be higher than a lamp and with higher energy efficiency. Also, the LED output may more easily be modulated, and the LED provides the option of continuous wave or pulsed mode of operation. LED's are solid state components that emit a wavelength band that is of moderate width, typically between about 20 nm to 40 nm. There are also so-called super-luminescent LEDs that may even emit over a much wider wavelength range. In another embodiment, a wide band light source may be constructed by combining different LEDs that emit in different wavelength bands, some of which could preferably overlap in spectrum. One advantage of LEDs as well as other solid state components is the compact size that they may be packaged into.
[0076] In yet another embodiment, various types of laser diodes may be used in the SWIR wavelength range. Just as LEDs may be higher in power but narrower in wavelength emission than lamps and thermal sources, the LDs may be yet higher in power but yet narrower in wavelength emission than LEDs. Different kinds of LDs may be used, including Fabry-Perot LDs, distributed feedback (DFB) LDs, distributed Bragg reflector (DBR) LDs. Since the LDs have relatively narrow wavelength range (typically under 10 nm), in one embodiment a plurality of LDs may be used that are at different wavelengths in the SWIR. The various LDs may be spatially multiplexed, polarization multiplexed, wavelength multiplexed, or a combination of these multiplexing methods. Also, the LDs may be fiber pig-tailed or have one or more lenses on the output to collimate or focus the light. Another advantage of LDs is that they may be packaged compactly and may have a spatially coherent beam output. Moreover, tunable LDs that can tune over a range of wavelengths are also available. The tuning may be done by varying the temperature, or electrical current may be used in particular structures such as distributed Bragg reflector (DBR) LDs, for example. In another embodiment, external cavity LDs may be used that have a tuning element, such as a fiber grating or a bulk grating, in the external cavity.
[0077] In another embodiment, super-luminescent laser diodes may provide higher power as well as broad bandwidth. An SLD is typically an edge emitting semiconductor light source based on super-luminescence (e.g., this could be amplified spontaneous emission). SLDs combine the higher power and brightness of LDs with the low coherence of conventional LEDs, and the emission band for SLD's may be 5 to 100 nm wide, preferably in the 60 to 100 nm range. Although currently SLDs are commercially available in the wavelength range of approximately 400 nm to 1700 nm, SLDs could and may in the future be made to cover a broader region of the SWIR.
[0078] In yet another embodiment, high power LDs for either direct excitation or to pump fiber lasers and SC light sources may be constructed using one or more laser diode bar stacks. FIG. 7 shows an example of a block diagram 700 or building blocks for constructing the high power LDs. In this embodiment, one or more diode bar stacks 701 may be used, where the diode bar stack may be an array of several single emitter LDs. Since the fast axis (e.g., vertical direction) may be nearly diffraction limited while the slow-axis (e.g., horizontal axis) may be far from diffraction limited, different collimators 702 may be used for the two axes.
[0079] Then, the brightness may be increased by spatially combining the beams from multiple stacks 703. The combiner may include spatial interleaving, it may include wavelength multiplexing, or it may involve a combination of the two. Different spatial interleaving schemes may be used, such as using an array of prisms or mirrors with spacers to bend one array of beams into the beam path of the other. In another embodiment, segmented mirrors with alternate high-reflection and anti-reflection coatings may be used. Moreover, the brightness may be increased by polarization beam combining 704 the two orthogonal polarizations, such as by using a polarization beam splitter. In a particular embodiment, the output may then be focused or coupled into a large diameter core fiber. As an example, typical dimensions for the large diameter core fiber range from diameters of approximately 100 microns to 400 microns or more. Alternatively or in addition, a custom beam shaping module 705 may be used, depending on the particular application. For example, the output of the high power LD may be used directly 706, or it may be fiber coupled 707 to combine, integrate, or transport the high power LD energy. These high power LDs may grow in importance because the LD powers can rapidly scale up. For example, instead of the power being limited by the power available from a single emitter, the power may increase in multiples depending on the number of diodes multiplexed and the size of the large diameter fiber. Although FIG. 7 is shown as one embodiment, some or all of the elements may be used in a high power LD, or additional elements may also be used.
SWIR Super-Continuum Lasers
[0080] Each of the light sources described above have particular strengths, but they also may have limitations. For example, there is typically a trade-off between wavelength range and power output. Also, sources such as lamps, thermal sources, and LEDs produce incoherent beams that may be difficult to focus to a small area and may have difficulty propagating for long distances. An alternative source that may overcome some of these limitations is an SC light source. Some of the advantages of the SC source may include high power and intensity, wide bandwidth, spatially coherent beam that can propagate nearly transform limited over long distances, and easy compatibility with fiber delivery.
[0081] Supercontinuum lasers may combine the broadband attributes of lamps with the spatial coherence and high brightness of lasers. By exploiting a modulational instability initiated supercontinuum (SC) mechanism, an all-fiber-integrated SC laser with no moving parts may be built using commercial-off-the-shelf (COTS) components. Moreover, the fiber laser architecture may be a platform where SC in the visible, near-infrared/SWIR, or mid-IR can be generated by appropriate selection of the amplifier technology and the SC generation fiber. But until recently, SC lasers were used primarily in laboratory settings since typically large, table-top, mode-locked lasers were used to pump nonlinear media such as optical fibers to generate SC light. However, those large pump lasers may now be replaced with diode lasers and fiber amplifiers that gained maturity in the telecommunications industry.
[0082] In one embodiment, an all-fiber-integrated, high-powered SC light source 800 may be elegant for its simplicity (FIG. 8 ). The light may be first generated from a seed laser diode 801. For example, the seed LD 801 may be a distributed feedback (DFB) laser diode with a wavelength near 1542 or 1550 nm, with approximately 0.5-2.0 ns pulsed output, and with a pulse repetition rate between about one kilohertz to about 100 MHz or more. The output from the seed laser diode may then be amplified in a multiple-stage fiber amplifier 802 comprising one or more gain fiber segments. In one embodiment, the first stage pre-amplifier 803 may be designed for optimal noise performance. For example, the pre-amplifier 803 may be a standard erbium-doped fiber amplifier or an erbium/ytterbium doped cladding pumped fiber amplifier. Between amplifier stages 803 and 806, it may be advantageous to use band-pass filters 804 to block amplified spontaneous emission and isolators 805 to prevent spurious reflections. Then, the power amplifier stage 806 may use a cladding-pumped fiber amplifier that may be optimized to minimize nonlinear distortion. The power amplifier fiber 806 may also be an erbium-doped fiber amplifier, if only low or moderate power levels are to be generated.
[0083] The SC generation 807 may occur in the relatively short lengths of fiber that follow the pump laser. The SC fiber length may range from around a few millimeters to 100 m or more. In one embodiment, the SC generation may occur in a first fiber 808 where the modulational-instability initiated pulse break-up occurs primarily, followed by a second fiber 809 where the SC generation and spectral broadening occurs primarily.
[0084] In one embodiment, one or two meters of standard single-mode fiber (SMF) after the power amplifier stage may be followed by several meters of SC generation fiber. For this example, in the SMF the peak power may be several kilowatts and the pump light may fall in the anomalous group-velocity dispersion regime—often called the soliton regime. For high peak powers in the anomalous dispersion regime, the nanosecond pulses may be unstable due to a phenomenon known as modulational instability, which is basically parametric amplification in which the fiber nonlinearity helps to phase match the pulses. As a consequence, the nanosecond pump pulses may be broken into many shorter pulses as the modulational instability tries to form soliton pulses from the quasi-continuous-wave background. Although the laser diode and amplification process starts with approximately nanosecond-long pulses, modulational instability in the short length of SMF fiber may form approximately 0.5 ps to several-picosecond-long pulses with high intensity. Thus, the few meters of SMF fiber may result in an output similar to that produced by mode-locked lasers, except in a much simpler and cost-effective manner.
[0085] The short pulses created through modulational instability may then be coupled into a nonlinear fiber for SC generation. The nonlinear mechanisms leading to broadband SC may include four-wave mixing or self-phase modulation along with the optical Raman effect. Since the Raman effect is self-phase-matched and shifts light to longer wavelengths by emission of optical photons, the SC may spread to longer wavelengths very efficiently. The short-wavelength edge may arise from four-wave mixing, and often times the short wavelength edge may be limited by increasing group-velocity dispersion in the fiber. In many instances, if the particular fiber used has sufficient peak power and SC fiber length, the SC generation process may fill the long-wavelength edge up to the transmission window.
[0086] Mature fiber amplifiers for the power amplifier stage 806 include ytterbium-doped fibers (near 1060 nm), erbium-doped fibers (near 1550 nm), erbium/ytterbium-doped fibers (near 1550 nm), or thulium-doped fibers (near 2000 nm). In various embodiments, candidates for SC fiber 809 include fused silica fibers (for generating SC between 0.8-2.7 μm), mid-IR fibers such as fluorides, chalcogenides, or tellurites (for generating SC out to 4.5 μm or longer), photonic crystal fibers (for generating SC between 0.4 and 1.7 μm), or combinations of these fibers. Therefore, by selecting the appropriate fiber-amplifier doping for 806 and nonlinear fiber 809, SC may be generated in the visible, near-IR/SWIR, or mid-IR wavelength region.
[0087] The configuration 800 of FIG. 8 is just one particular example, and other configurations can be used and are intended to be covered by this disclosure. For example, further gain stages may be used, and different types of lossy elements or fiber taps may be used between the amplifier stages. In another embodiment, the SC generation may occur partially in the amplifier fiber and in the pig-tails from the pump combiner or other elements. In yet another embodiment, polarization maintaining fibers may be used, and a polarizer may also be used to enhance the polarization contrast between amplifier stages. Also, not discussed in detail are many accessories that may accompany this set-up, such as driver electronics, pump laser diodes, safety shut-offs, and thermal management and packaging.
[0088] In one embodiment, one example of the SC laser that operates in the SWIR is illustrated in FIG. 9 . This SWIR SC source 900 produces an output of up to approximately 5 W over a spectral range of about 1.5 to 2.4 microns, and this particular laser is made out of polarization maintaining components. The seed laser 901 is a distributed feedback (DFB) laser operating near 1542 nm producing approximately 0.5 nsec pulses at an about 8 MHz repetition rate. The pre-amplifier 902 is forward pumped and uses about 2 m length of erbium/ytterbium cladding pumped fiber 903 (often also called dual-core fiber) with an inner core diameter of 12 microns and outer core diameter of 130 microns. The pre-amplifier gain fiber 903 is pumped using a 10 W laser diode near 940 nm 905 that is coupled in using a fiber combiner 904.
[0089] In this particular 5 W unit, the mid-stage between amplifier stages 902 and 906 comprises an isolator 907, a band-pass filter 908, a polarizer 909 and a fiber tap 910. The power amplifier 906 uses an approximately 4 m length of the 12/130 micron erbium/ytterbium doped fiber 911 that is counter-propagating pumped using one or more 30 W laser diodes near 940 nm 912 coupled in through a combiner 913. An approximately 1-2 meter length of the combiner pig-tail helps to initiate the SC process, and then a length of PM-1550 fiber 915 (polarization maintaining, single-mode, fused silica fiber optimized for 1550 nm) is spliced 914 to the combiner output.
[0090] If an output fiber of about 10 m in length is used, then the resulting output spectrum 1000 is shown in FIG. 10 . The details of the output spectrum 1000 depend on the peak power into the fiber, the fiber length, and properties of the fiber such as length and core size, as well as the zero dispersion wavelength and the dispersion properties. For example, if a shorter length of fiber is used, then the spectrum actually reaches to longer wavelengths (e.g., a 2 m length of SC fiber broadens the spectrum to about 2500 nm). Also, if extra-dry fibers are used with less O-H content, then the wavelength edge may also reach to a longer wavelength. To generate more spectra toward the shorter wavelengths, the pump wavelength (in this case ˜1542 nm) should be close to the zero dispersion wavelength in the fiber. For example, by using a dispersion shifted fiber or so-called non-zero dispersion shifted fiber, the short wavelength edge may shift to shorter wavelengths.
[0091] In one particular embodiment, the SWIR-SC light source of FIG. 9 with output spectrum in FIG. 10 was used in preliminary experiments for examining the reflectance from different dental samples. A schematic of the experimental set-up 1100 for measuring the diffuse reflectance spectroscopy is illustrated in FIG. 11A . The SC source 1101 in this embodiment was based on the design of FIG. 9 and delivered approximately 1.6 W of light over the wavelength range from about 1500-2400 nm. The output beam 1102 was collimated, and then passed through a chopper 1103 (for lock-in detection at the receiver after the spectrometer 1106) and an aperture 1104 for localizing the beam on the tooth location. Different teeth 1105 with different lesions and caries were placed in front of the aperture 1104, and the scattered light was passed through a spectrometer 1106 and collected on a detector, whose signal was sent to a receiver. The tooth samples 1105 were mounted in clay or putty for standing upright. Different types of teeth could be used, including molars, premolars, canine and incisor teeth.
[0092] FIG. 11B shows exemplary reflectance spectra 1150 from a sound enamel region 1151 (e.g., without dental caries), an enamel lesion region 1152, and a dentine lesion region 1153 of various teeth. The spectra are normalized to have equal value near 2050 nm. In this particular embodiment, the slope from the sound enamel 1151 is steepest between about 1500 and 1950 nm, with a lesser slope in the presence of an enamel lesion 1152. When there is a sample with dentine lesion 1153, more features appear in the spectrum from the presence of water absorption lines from water that collects in the dentine. For this experiment, the spectra 1151, 1152, and 1153 are flatter in the wavelength region between about 1950 nm and 2350 nm. These are preliminary results, but they show the benefit of using broadband sources such as the SWIR-SC source for diagnosing dental caries. Although the explanation behind the different spectra 1150 of FIG. 11B may not be understood as yet, it is clear that the spectra 1151, 1152 and 1153 are distinguishable. Therefore, the broadband reflectance may be used for detection of dental caries and analyzing the region of the caries. Although diffuse reflectance has been used in this experiment, other signals, such as transmission, reflectance or a combination, may also be used and are covered by this disclosure.
[0093] Although one particular example of a 5 W SWIR-SC has been described, different components, different fibers, and different configurations may also be used consistent with this disclosure. For instance, another embodiment of the similar configuration 900 in FIG. 9 may be used to generate high powered SC between approximately 1060 and 1800 nm. For this embodiment, the seed laser 901 may be a distributed feedback laser diode of about 1064 nm, the pre-amplifier gain fiber 903 may be a ytterbium-doped fiber amplifier with 10/125 microns dimensions, and the pump laser 905 may be a 10 W laser diode near 915 nm. A mode field adapter may be including in the mid-stage, in addition to the isolator 907, band pass filter 908, polarizer 909 and tap 910. The gain fiber 911 in the power amplifier may be an about 20 m length of ytterbium-doped fiber with 25/400 microns dimension. The pump 912 for the power amplifier may be up to six pump diodes providing 30 W each near 915 nm. For this much pump power, the output power in the SC may be as high as 50 W or more.
[0094] In an alternate embodiment, it may be desirous to generate high power SWIR SC over 1.4-1.8 microns and separately 2-2.5 microns (the window between 1.8 and 2 microns may be less important due to the strong water and atmospheric absorption). For example, the SC source of FIG. 12A can lead to bandwidths ranging from about 1400 nm to 1800 nm or broader, while the SC source of FIG. 12B can lead to bandwidths ranging from about 1900 nm to 2500 nm or broader. Since these wavelength ranges are shorter than about 2500 nm, the SC fiber can be based on fused silica fiber. Exemplary SC fibers include standard single-mode fiber (SMF), high-nonlinearity fiber, high-NA fiber, dispersion shifted fiber, dispersion compensating fiber, and photonic crystal fibers. Non-fused-silica fibers can also be used for SC generation, including chalcogenides, fluorides, ZBLAN, tellurites, and germanium oxide fibers.
[0095] In one embodiment, FIG. 12A illustrates a block diagram for an SC source 1200 capable of generating light between approximately 1400 and 1800 nm or broader. As an example, a pump fiber laser similar to FIG. 9 can be used as the input to a SC fiber 1209. The seed laser diode 1201 can comprise a DFB laser that generates, for example, several milliwatts of power around 1542 nm or 1553 nm. The fiber pre-amplifier 1202 can comprise an erbium-doped fiber amplifier or an erbium/ytterbium doped double clad fiber. In this example a mid-stage amplifier 1203 can be used, which can comprise an erbium/ytterbium doped double-clad fiber. A bandpass filter 1205 and isolator 1206 may be used between the pre-amplifier 1202 and mid-stage amplifier 1203. The power amplifier stage 1204 can comprise a larger core size erbium/ytterbium doped double-clad fiber, and another bandpass filter 1207 and isolator 1208 can be used before the power amplifier 1204. The output of the power amplifier can be coupled to the SC fiber 1209 to generate the SC output 1210. This is just one exemplary configuration for an SC source, and other configurations or elements may be used consistent with this disclosure.
[0096] In yet another embodiment, FIG. 12B illustrates a block diagram for an SC source 1250 capable of generating light between approximately 1900 and 2500 nm or broader. As an example, the seed laser diode 1251 can comprise a DFB or DBR laser that generates, for example, several milliwatts of power around 1542 nm or 1553 nm. The fiber pre-amplifier 1252 can comprise an erbium-doped fiber amplifier or an erbium/ytterbium doped double-clad fiber. In this example a mid-stage amplifier 1253 can be used, which can comprise an erbium/ytterbium doped double-clad fiber. A bandpass filter 1255 and isolator 1256 may be used between the pre-amplifier 1252 and mid-stage amplifier 1253. The power amplifier stage 1254 can comprise a thulium doped double-clad fiber, and another isolator 1257 can be used before the power amplifier 1254. Note that the output of the mid-stage amplifier 1253 can be approximately near 1542 nm, while the thulium-doped fiber amplifier 1254 can amplify wavelengths longer than approximately 1900 nm and out to about 2100 nm. Therefore, for this configuration wavelength shifting may be required between 1253 and 1254. In one embodiment, the wavelength shifting can be accomplished using a length of standard single-mode fiber 1258, which can have a length between approximately 5 and 50 meters, for example. The output of the power amplifier 1254 can be coupled to the SC fiber 1259 to generate the SC output 1260. This is just one exemplary configuration for an SC source, and other configurations or elements can be used consistent with this disclosure. For example, the various amplifier stages can comprise different amplifier types, such as erbium doped fibers, ytterbium doped fibers, erbium/ytterbium co-doped fibers and thulium doped fibers.
[0097] FIG. 12C illustrates a reflection-spectroscopy based stand-off detection system having an SC laser source. The set-up 1270 for the reflection-spectroscopy-based stand-off detection system includes an SC source 1271. First, the diverging SC output is collimated to a 1 cm diameter beam using a 25 mm focal length, 90 degrees off-axis, gold coated, parabolic mirror 1272. To reduce the effects of chromatic aberration, refractive optics are avoided in the setup. All focusing and collimation is done using metallic mirrors that have almost constant reflectivity and focal length over the entire SC output spectrum. The sample 1274 is kept at a distance from the collimating mirror 1272, which provides a total round trip path length of twice the distance before reaching the collection optics 1275. A 12 cm diameter silver coated concave mirror 1275 with a 75 cm focal length is kept 20 cm to the side of the collimation mirror 1272. The mirror 1275 is used to collect a fraction of the diffusely reflected light from the sample, and focus it into the input slit of a monochromator 1276. Thus, the beam is incident normally on the sample 1274, but detected at a reflection angle of tan−1 (0.2/5) or about 2.3 degrees. Appropriate long wavelength pass filters mounted in a motorized rotating filter wheel are placed in the beam path before the input slit 1276 to avoid contribution from higher wavelength orders from the grating (300 grooves/mm, 2 μm blaze). The output slit width is set to 2 mm corresponding to a spectral resolution of 10.8 nm, and the light is detected by a 2 mm×2 mm liquid nitrogen cooled (77K) indium antimonide (InSb) detector 1277. The detected output is amplified using a trans-impedance pre-amplifier 1277 with a gain of about 105V/A and connected to a lock-in amplifier 1278 setup for high sensitivity detection. The chopper frequency is 400 Hz, and the lock-in time constant is set to 100 ms corresponding to a noise bandwidth of about 1 Hz. These are exemplary elements and parameter values, but other or different optical elements may be used consistent with this disclosure.
[0098] By use of an active illuminator, a number of advantages may be achieved, such as higher signal-to-noise ratios. For example, one way to improve the signal-to-noise ratio would be to use modulation and lock-in techniques. In one embodiment, the light source may be modulated, and then the detection system would be synchronized with the light source. In a particular embodiment, the techniques from lock-in detection may be used, where narrow band filtering around the modulation frequency may be used to reject noise outside the modulation frequency. In an alternate embodiment, change detection schemes may be used, where the detection system captures the signal with the light source on and with the light source off. Again, for this system the light source may be modulated. Then, the signal with and without the light source is differenced. This may enable the sun light changes to be subtracted out. In addition, change detection may help to identify objects that change in the field of view. In the following some exemplary detection systems are described.
[0099] One advantage of the SC lasers illustrated in FIGS. 8, 9, and 12 is that they may use all-fiber components, so that the SC laser can be all-fiber, monolithically integrated with no moving parts. The all-integrated configuration can consequently be robust and reliable.
[0100] FIGS. 8, 9, and 12 are examples of SC light sources that may advantageously be used for SWIR light generation in various medical and dental diagnostic and therapeutic applications. However, many other versions of the SC light sources may also be made that are intended to also be covered by this disclosure. For example, the SC generation fiber could be pumped by a mode-locked laser, a gain-switched semiconductor laser, an optically pumped semiconductor laser, a solid state laser, other fiber lasers, or a combination of these types of lasers. Also, rather than using a fiber for SC generation, either a liquid or a gas cell might be used as the nonlinear medium in which the spectrum is to be broadened.
[0101] Even within the all-fiber versions illustrated such as in FIG. 9 , different configurations could be used consistent with the disclosure. In an alternate embodiment, it may be desirous to have a lower cost version of the SWIR SC laser of FIG. 9 . One way to lower the cost could be to use a single stage of optical amplification, rather than two stages, which may be feasible if lower output power is required or the gain fiber is optimized. For example, the pre-amplifier stage 902 might be removed, along with at least some of the mid-stage elements. In yet another embodiment, the gain fiber could be double passed to emulate a two stage amplifier. In this example, the pre-amplifier stage 902 might be removed, and perhaps also some of the mid-stage elements. A mirror or fiber grating reflector could be placed after the power amplifier stage 906 that may preferentially reflect light near the wavelength of the seed laser 901. If the mirror or fiber grating reflector can transmit the pump light near 940 nm, then this could also be used instead of the pump combiner 913 to bring in the pump light 912. The SC fiber 915 could be placed between the seed laser 901 and the power amplifier stage 906 (SC is only generated after the second pass through the amplifier, since the power level may be sufficiently high at that time). In addition, an output coupler may be placed between the seed laser diode 901 and the SC fiber, which now may be in front of the power amplifier 906. In a particular embodiment, the output coupler could be a power coupler or divider, a dichroic coupler (e.g., passing seed laser wavelength but outputting the SC wavelengths), or a wavelength division multiplexer coupler. This is just one further example, but a myriad of other combinations of components and architectures could also be used for SC light sources to generate SWIR light that are intended to be covered by this disclosure.
Wireless Link to the Cloud
[0102] The non-invasive dental caries measurement device may also benefit from communicating the data output to the “cloud” (e.g., data servers and processors in the web remotely connected) via wireless means. The non-invasive devices may be part of a series of biosensors applied to the patient, and collectively these devices form what might be called a body area network or a personal area network. The biosensors and non-invasive devices may communicate to a smart phone, tablet, personal data assistant, computer and/or other microprocessor-based device, which may in turn wirelessly or over wire and/or fiber optic transmit some or all of the signal or processed data to the internet or cloud. The cloud or internet may in turn send the data to dentists, doctors or health care providers as well as the patients themselves. Thus, it may be possible to have a panoramic, high-definition, relatively comprehensive view of a patient that doctors and dentists can use to assess and manage disease, and that patients can use to help maintain their health and direct their own care.
[0103] In a particular embodiment 1300, the non-invasive measurement device 1301 may comprise a transmitter 1303 to communicate over a first communication link 1304 in the body area network or personal area network to a receiver in a smart phone, tablet, cell phone, PDA, and/or computer 1305, for example. For the measurement device 1301, it may also be advantageous to have a processor 1302 to process some of the measured data, since with processing the amount of data to transmit may be less (hence, more energy efficient). The first communication link 1304 may operate through the use of one of many wireless technologies such as Bluetooth, Zigbee, WiFi, IrDA (infrared data association), wireless USB, or Z-wave, to name a few. Alternatively, the communication link 1304 may occur in the wireless medical band between 2360 MHz and 2390 MHz, which the FCC allocated for medical body area network devices, or in other designated medical device or WMTS bands. These are examples of devices that can be used in the body area network and surroundings, but other devices could also be used and are included in the scope of this disclosure.
[0104] The personal device 1305 may store, process, display, and transmit some of the data from the measurement device 1301. The device 1305 may comprise a receiver, transmitter, display, voice control and speakers, and one or more control buttons or knobs and a touch screen. Examples of the device 1305 include smart phones such as the Apple iPhones® or phones operating on the Android or Microsoft systems. In one embodiment, the device 1305 may have an application, software program, or firmware to receive and process the data from the measurement device 1301. The device 1305 may then transmit some or all of the data or the processed data over a second communication link 1306 to the internet or “cloud” 1307. The second communication link 1306 may advantageously comprise at least one segment of a wireless transmission link, which may operate using WiFi or the cellular network. The second communication link 1306 may additionally comprise lengths of fiber optic and/or communication over copper wires or cables.
[0105] The internet or cloud 1307 may add value to the measurement device 1301 by providing services that augment the measured data collected. In a particular embodiment, some of the functions performed by the cloud include: (a) receive at least a fraction of the data from the device 1305; (b) buffer or store the data received; (c) process the data using software stored on the cloud; (d) store the resulting processed data; and (e) transmit some or all of the data either upon request or based on an alarm. As an example, the data or processed data may be transmitted 1308 back to the originator (e.g., patient or user), it may be transmitted 1309 to a health care provider or doctor or dentist, or it may be transmitted 1310 to other designated recipients.
[0106] Service providers coupled to the cloud 1307 may provide a number of value-add services. For example, the cloud application may store and process the dental data for future reference or during a visit with the dentist or healthcare provider. If a patient has some sort of medical mishap or emergency, the physician can obtain the history of the dental or physiological parameters over a specified period of time. In another embodiment, alarms, warnings or reminders may be delivered to the user 1308, the healthcare provider 1309, or other designated recipients 1310. These are just some of the features that may be offered, but many others may be possible and are intended to be covered by this disclosure. As an example, the device 1305 may also have a GPS sensor, so the cloud 1307 may be able to provide time, date, and position along with the dental or physiological parameters. Thus, if there is a medical or dental emergency, the cloud 1307 could provide the location of the patient to the dental or healthcare provider 1309 or other designated recipients 1310. Moreover, the digitized data in the cloud 1307 may help to move toward what is often called “personalized medicine.” Based on the dental or physiological parameter data history, medication or medical/dental therapies may be prescribed that are customized to the particular patient. Another advantage for commercial entities may be that by leveraging the advances in wireless connectivity and the widespread use of handheld devices such as smart phones that can wirelessly connect to the cloud, businesses can build a recurring cost business model even using non-invasive measurement devices.
[0107] Described herein are just some examples of the beneficial use of near-infrared or SWIR lasers for non-invasive measurements of dental caries and early detection of carious regions. However, many other dental or medical procedures can use the near-infrared or SWIR light consistent with this disclosure and are intended to be covered by the disclosure.
[0108] Although the present disclosure has been described in several embodiments, a myriad of changes, variations, alterations, transformations, and modifications may be suggested to one skilled in the art, and it is intended that the present disclosure encompass such changes, variations, alterations, transformations, and modifications as falling within the spirit and scope of the appended claims.
[0109] While exemplary embodiments are described above, it is not intended that these embodiments describe all possible forms of the disclosure. Rather, the words used in the specification are words of description rather than limitation, and it is understood that various changes may be made without departing from the spirit and scope of the disclosure. Additionally, the features of various implementing embodiments may be combined to form further embodiments of the disclosure. While various embodiments may have been described as providing advantages or being preferred over other embodiments with respect to one or more desired characteristics, as one skilled in the art is aware, one or more characteristics may be compromised to achieve desired system attributes, which depend on the specific application and implementation. These attributes include, but are not limited to: cost, strength, durability, life cycle cost, marketability, appearance, packaging, size, serviceability, weight, manufacturability, ease of assembly, etc. The embodiments described herein that are described as less desirable than other embodiments or prior art implementations with respect to one or more characteristics are not outside the scope of the disclosure and may be desirable for particular applications.
Claims
What is claimed is:
1. A wearable device for use with a smart phone or tablet, the wearable device comprising:
a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths, wherein at least one of the LEDs emits at a first wavelength having a first penetration depth into tissue and at least another of the LEDs emits at a second wavelength having a second penetration depth into the tissue different from the first penetration depth, wherein at least a portion of the optical beam includes a near-infrared wavelength between 700 nanometers and 2500 nanometers;
the measurement device comprising one or more lenses configured to receive and to deliver at least a portion of each of the first and of the second wavelengths to tissue, wherein the tissue reflects at least a portion of each of the first and of the second wavelengths;
the measurement device further comprising a receiver configured to:
capture light while the LEDs are off and convert the captured light into a first signal and
capture light while at least one of the LEDs is on and to convert the captured light into a second signal, the captured light including at least a portion of one of the first or second wavelengths reflected from the tissue;
the measurement device configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal;
the light source configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs;
the measurement device further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue.
2. The wearable device of claim 1, wherein the measurement device is adapted to be placed on a wrist of a user.
3. The wearable device of claim 1, wherein the measurement device is adapted to be placed on an ear of a user.
4. The wearable device of claim 1, wherein the second wavelength is between 900 nanometers and 1150 nanometers.
5. The wearable device of claim 1, wherein
the wearable device is configured to communicate with the smart phone or tablet, the smart phone or tablet comprising a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen, the smart phone or tablet configured to receive and to process at least a portion of the output signal, wherein the smart phone or tablet is configured to store and display the processed output signal, wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link.
6. The wearable device of claim 1, wherein the receiver is configured to be synchronized to the modulation of at least one of the LEDs.
7. The wearable device of claim 1, wherein the receiver is located a first distance from a first one of the LEDs and a different distance from a second one of the LEDs such that the receiver can capture a third signal from the first LED and a fourth signal from the second LED, and wherein the output signal is generated in part by comparing the third and fourth signals.
8. The wearable device of claim 1, wherein the output signal is generated in part by comparing the reflected light at the first wavelength with the reflected light at the second wavelength.
9. A wearable device for use with a smart phone or tablet, the wearable device comprising:
a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths, wherein at least a portion of the plurality of optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
the measurement device comprising one or more lenses configured to receive and to deliver a portion of the optical beam to tissue, wherein the tissue reflects at least a portion of the optical beam delivered to the tissue, and wherein the measurement device is adapted to be placed on a wrist or an ear of a user;
the measurement device further comprising a receiver configured to:
capture light while the LEDs are off and convert the captured light into a first signal and
capture light while at least one of the LEDs is on and convert the captured light into a second signal, the captured light including at least a portion of the optical beam reflected from the tissue;
the measurement device configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal;
the light source configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs;
the measurement device further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue.
10. The wearable device of claim 9, wherein at least one LED emits at a first wavelength and at least another LED emits at a second wavelength, and wherein the first wavelength has a first penetration depth into the tissue and wherein the second wavelength has a second penetration depth into the tissue different from the first penetration depth.
11. The wearable device of claim 10, wherein the output signal is generated in part by comparing the reflected light at the first wavelength with the reflected light at the second wavelength.
12. The wearable device of claim 10, wherein the second wavelength is between 900 nanometers and 1150 nanometers.
13. The wearable device of claim 9, wherein
the wearable device is configured to communicate with the smart phone or tablet, the smart phone or tablet comprising a wireless receiver, a wireless transmitter, a display, a voice input module, a speaker, and a touch screen, the smart phone or tablet configured to receive and to process at least a portion of the output signal, wherein the smart phone or tablet is configured to store and display the processed output signal, wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link.
14. The wearable device of claim 9, wherein the receiver is configured to be synchronized to the modulation of the at least one of the LEDs.
15. The wearable device of claim 9, wherein the receiver is located a first distance from a first one of the LEDs and a different distance from a second one of the LEDs such that the receiver can capture a third signal from the first LED and a fourth signal from the second LED, and wherein the output signal is generated in part by comparing the third and fourth signals.
16. A wearable device for use with a smart phone or tablet, the wearable device comprising:
a measurement device including a light source comprising a plurality of light emitting diodes (LEDs) for measuring one or more physiological parameters, the measurement device configured to generate, by modulating at least one of the LEDs having an initial light intensity, an optical beam having a plurality of optical wavelengths, wherein at least a portion of the plurality of optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
the measurement device comprising one or more lenses configured to receive and to deliver a portion of the optical beam to tissue, wherein the tissue reflects at least a portion of the optical beam delivered to the tissue, and wherein the measurement device is adapted to be placed on a wrist or an ear of a user;
the measurement device further comprising a receiver configured to:
capture light while the LEDs are off and convert the captured light into a first signal and
capture light while at least one of the LEDs is on and convert the captured light into a second signal, the captured light including at least a portion of the optical beam reflected from the tissue;
the measurement device configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal;
the light source configured to further improve the signal-to-noise ratio of the optical beam reflected from the tissue by increasing the light intensity relative to the initial light intensity from at least one of the LEDs;
the measurement device further configured to generate an output signal representing at least in part a non-invasive measurement on blood contained within the tissue; and
wherein the receiver includes a plurality of spatially separated detectors, wherein at least one analog to digital converter is coupled to the spatially separated detectors.
17. The wearable device of claim 16, wherein at least one LED emits at a first wavelength and at least another LED emits at a second wavelength, and wherein the first wavelength has a first penetration depth into the tissue and wherein the second wavelength has a second penetration depth into the tissue different from the first penetration depth.
18. The wearable device of claim 17, wherein the output signal is generated in part by comparing the reflected light at the first wavelength with the reflected light at the second wavelength.
19. The wearable device of claim 16, wherein the receiver is configured to be synchronized to the modulating of at least one of the LEDs.
20. The wearable device of claim 16, wherein the receiver is located a first distance from a first one of the LEDs and a different distance from a second one of the LEDs such that the receiver can capture a third signal from the first LED and a fourth signal from the second LED, and wherein the output signal is generated in part by comparing the third and fourth signals.
Patent Citations (197)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US4063106(A) | 1977-12-01 | Ashkin et al. | Applicant |
| US4158750(A) | 1979-06-01 | Sakoe et al. | Applicant |
| US4221997(A) | 1980-09-01 | Flemming | Applicant |
| US4275266(A) | 1981-06-01 | Lasar | Applicant |
| US4374618(A) | 1983-02-01 | Howard | Applicant |
| US4403605(A) | 1983-09-01 | Tanikawa | Applicant |
| US4462080(A) | 1984-07-01 | Johnstone et al. | Applicant |
| US4516207(A) | 1985-05-01 | Moriyama et al. | Applicant |
| US4523884(A) | 1985-06-01 | Clement et al. | Applicant |
| US4605080(A) | 1986-08-01 | Lemelson | Applicant |
| US4641292(A) | 1987-02-01 | Tunnell et al. | Applicant |
| US4704696(A) | 1987-11-01 | Reimer et al. | Applicant |
| US4728974(A) | 1988-03-01 | Nio et al. | Applicant |
| US4762455(A) | 1988-08-01 | Coughlan et al. | Applicant |
| US4776016(A) | 1988-10-01 | Hansen | Applicant |
| US4958910(A) | 1990-09-01 | Taylor et al. | Applicant |
| US4989253(A) | 1991-01-01 | Liang et al. | Applicant |
| US5078140(A) | 1992-01-01 | Kwoh | Applicant |
| US5084880(A) | 1992-01-01 | Esterowitz et al. | Applicant |
| US5086401(A) | 1992-02-01 | Glassman et al. | Applicant |
| US5134620(A) | 1992-07-01 | Huber | Applicant |
| US5142930(A) | 1992-09-01 | Allen et al. | Applicant |
| US5180378(A) | 1993-01-01 | Kung et al. | Applicant |
| US5191628(A) | 1993-03-01 | Byron | Applicant |
| US5218655(A) | 1993-06-01 | Mizrahi | Applicant |
| US5230023(A) | 1993-07-01 | Nakano | Applicant |
| US5246004(A) | 1993-09-01 | Clarke et al. | Applicant |
| US5267152(A) | 1993-11-01 | Yang et al. | Applicant |
| US5267256(A) | 1993-11-01 | Saruwatari et al. | Applicant |
| US5267323(A) | 1993-11-01 | Kimura | Applicant |
| US5300097(A) | 1994-04-01 | Lerner et al. | Applicant |
| US5303148(A) | 1994-04-01 | Mattson et al. | Applicant |
| US5305427(A) | 1994-04-01 | Nagata | Applicant |
| US5313306(A) | 1994-05-01 | Kuban et al. | Applicant |
| US5323404(A) | 1994-06-01 | Grubb | Applicant |
| US5345538(A) | 1994-09-01 | Narayannan et al. | Applicant |
| US5400165(A) | 1995-03-01 | Gnauck et al. | Applicant |
| US5408409(A) | 1995-04-01 | Glassman et al. | Applicant |
| US5458122(A) | 1995-10-01 | Hethuin | Applicant |
| US5544654(A) | 1996-08-01 | Murphy et al. | Applicant |
| US5572999(A) | 1996-11-01 | Funda et al. | Applicant |
| US5617871(A) | 1997-04-01 | Burrows | Applicant |
| US5631758(A) | 1997-05-01 | Knox et al. | Applicant |
| US5687734(A) | 1997-11-01 | Dempsey et al. | Applicant |
| US5695493(A) | 1997-12-01 | Nakajima et al. | Applicant |
| US5696778(A) | 1997-12-01 | MacPherson | Applicant |
| US5704351(A) | 1998-01-01 | Mortara et al. | Applicant |
| US5718234(A) | 1998-02-01 | Warden et al. | Applicant |
| US5747806(A) | 1998-05-01 | Khalil | Applicant |
| US5748103(A) | 1998-05-01 | Flach et al. | Applicant |
| US5792204(A) | 1998-08-01 | Snell | Applicant |
| US5812978(A) | 1998-09-01 | Nolan | Applicant |
| US5855550(A) | 1999-01-01 | Lai et al. | Applicant |
| US5862803(A) | 1999-01-01 | Besson et al. | Applicant |
| US5867305(A) | 1999-02-01 | Waarts et al. | Applicant |
| US5912749(A) | 1999-06-01 | Harstead et al. | Applicant |
| US5944659(A) | 1999-08-01 | Flach et al. | Applicant |
| US5950629(A) | 1999-09-01 | Taylor et al. | Applicant |
| US5957854(A) | 1999-09-01 | Besson et al. | Applicant |
| US5970457(A) | 1999-10-01 | Brant et al. | Applicant |
| US6014249(A) | 2000-01-01 | Fermann et al. | Applicant |
| US6043927(A) | 2000-03-01 | Islam | Applicant |
| US6115673(A) | 2000-09-01 | Malin | Applicant |
| US6185535(B1) | 2001-02-01 | Hedin et al. | Applicant |
| US6200309(B1) | 2001-03-01 | Rice et al. | Applicant |
| US6224542(B1) | 2001-05-01 | Chang et al. | Applicant |
| US6246707(B1) | 2001-06-01 | Yin et al. | Applicant |
| US6246896(B1) | 2001-06-01 | Dumoulin | Applicant |
| US6273858(B1) | 2001-08-01 | Fox et al. | Applicant |
| US6278975(B1) | 2001-08-01 | Brant et al. | Applicant |
| US6281471(B1) | 2001-08-01 | Smart | Applicant |
| US6285897(B1) | 2001-09-01 | Kilcoyne | Applicant |
| US6289238(B1) | 2001-09-01 | Besson et al. | Applicant |
| US6301271(B1) | 2001-10-01 | Sanders et al. | Applicant |
| US6301273(B1) | 2001-10-01 | Sanders et al. | Applicant |
| US6333803(B1) | 2001-12-01 | Kurotori et al. | Applicant |
| US6337462(B1) | 2002-01-01 | Smart | Applicant |
| US6340806(B1) | 2002-01-01 | Smart et al. | Applicant |
| US6350261(B1) | 2002-02-01 | Domankevitz et al. | Applicant |
| US6364834(B1) | 2002-04-01 | Reuss et al. | Applicant |
| US6374006(B1) | 2002-04-01 | Islam et al. | Applicant |
| US6381391(B1) | 2002-04-01 | Islam et al. | Applicant |
| US6402691(B1) | 2002-06-01 | Peddicord et al. | Applicant |
| US6407853(B1) | 2002-06-01 | Samson et al. | Applicant |
| US6436107(B1) | 2002-08-01 | Wang et al. | Applicant |
| US6441747(B1) | 2002-08-01 | Khair et al. | Applicant |
| US6442430(B1) | 2002-08-01 | Ferek-Petric | Applicant |
| US6443890(B1) | 2002-09-01 | Schulze et al. | Applicant |
| US6450172(B1) | 2002-09-01 | Hartlaub et al. | Applicant |
| US6453201(B1) | 2002-09-01 | Daum et al. | Applicant |
| US6454705(B1) | 2002-09-01 | Cosentino et al. | Applicant |
| US6458120(B1) | 2002-10-01 | Shen et al. | Applicant |
| US6462500(B1) | 2002-10-01 | L'Hegarat et al. | Applicant |
| US6463361(B1) | 2002-10-01 | Wang et al. | Applicant |
| US6480656(B1) | 2002-11-01 | Islam et al. | Applicant |
| US6512936(B1) | 2003-01-01 | Monfre | Applicant |
| US6534012(B1) | 2003-03-01 | Hazen et al. | Applicant |
| US6549702(B2) | 2003-04-01 | Islam et al. | Applicant |
| US6567431(B2) | 2003-05-01 | Tabirian et al. | Applicant |
| US6587702(B1) | 2003-07-01 | Ruchti | Applicant |
| US6603910(B2) | 2003-08-01 | Islam et al. | Applicant |
| US6605080(B1) | 2003-08-01 | Altshuler et al. | Applicant |
| US6611643(B2) | 2003-08-01 | Birk | Applicant |
| US6625180(B2) | 2003-09-01 | Bufetov et al. | Applicant |
| US6631025(B2) | 2003-10-01 | Islam et al. | Applicant |
| US6640117(B2) | 2003-10-01 | Makarewicz | Applicant |
| US6659947(B1) | 2003-12-01 | Carter et al. | Applicant |
| US6659999(B1) | 2003-12-01 | Anderson et al. | Applicant |
| US6738652(B2) | 2004-05-01 | Mattu | Applicant |
| US6760148(B2) | 2004-07-01 | Islam | Applicant |
| US6773922(B2) | 2004-08-01 | Jeng | Applicant |
| US6788965(B2) | 2004-09-01 | Ruchti | Applicant |
| US6802811(B1) | 2004-10-01 | Slepian | Applicant |
| US6816241(B2) | 2004-11-01 | Grubisic | Applicant |
| US6847336(B1) | 2005-01-01 | Lemelson | Applicant |
| US6864978(B1) | 2005-03-01 | Hazen | Applicant |
| US6885498(B2) | 2005-04-01 | Islam | Applicant |
| US6885683(B1) | 2005-04-01 | Fermann et al. | Applicant |
| US6943936(B2) | 2005-09-01 | Islam et al. | Applicant |
| US6990364(B2) | 2006-01-01 | Ruchti | Applicant |
| US7010336(B2) | 2006-03-01 | Lorenz | Applicant |
| US7027467(B2) | 2006-04-01 | Baev et al. | Applicant |
| US7060061(B2) | 2006-06-01 | Altshuler et al. | Applicant |
| US7133710(B2) | 2006-11-01 | Acosta | Applicant |
| US7167300(B2) | 2007-01-01 | Fermann et al. | Applicant |
| US7209657(B1) | 2007-04-01 | Islam | Applicant |
| US7233816(B2) | 2007-06-01 | Blank | Applicant |
| US7259906(B1) | 2007-08-01 | Islam | Applicant |
| US7263288(B1) | 2007-08-01 | Islam | Applicant |
| US7294105(B1) | 2007-11-01 | Islam | Applicant |
| US7299080(B2) | 2007-11-01 | Acosta | Applicant |
| US7317938(B2) | 2008-01-01 | Lorenz | Applicant |
| US7318909(B2) | 2008-01-01 | Lehmann et al. | Applicant |
| US7356364(B1) | 2008-04-01 | Bullock et al. | Applicant |
| US7395158(B2) | 2008-07-01 | Monfre | Applicant |
| US7433116(B1) | 2008-10-01 | Islam | Applicant |
| US7519253(B2) | 2009-04-01 | Islam | Applicant |
| US7519406(B2) | 2009-04-01 | Blank | Applicant |
| US7620674(B2) | 2009-11-01 | Ruchti | Applicant |
| US7697966(B2) | 2010-04-01 | Monfre | Applicant |
| US7787503(B2) | 2010-08-01 | Wadsworth | Applicant |
| US7787924(B2) | 2010-08-01 | Acosta | Applicant |
| US7800818(B2) | 2010-09-01 | Mattsson | Applicant |
| US7807718(B2) | 2010-10-01 | Hashim | Applicant |
| US8000574(B2) | 2011-08-01 | Buchter | Applicant |
| US8145286(B2) | 2012-03-01 | Arai | Applicant |
| US8180422(B2) | 2012-05-01 | Rebec | Applicant |
| US8472108(B2) | 2013-06-01 | Islam | Applicant |
| US9207121(B2) | 2015-12-01 | Adler | Applicant |
| US2002/0013518(A1) | 2002-01-01 | West et al. | Applicant |
| US2002/0019584(A1) | 2002-02-01 | Schulze et al. | Applicant |
| US2002/0032468(A1) | 2002-03-01 | Hill et al. | Applicant |
| US2002/0082612(A1) | 2002-06-01 | Moll et al. | Applicant |
| US2002/0109621(A1) | 2002-08-01 | Khair et al. | Applicant |
| US2002/0115914(A1) | 2002-08-01 | Russ | Applicant |
| US2002/0128846(A1) | 2002-09-01 | Miller | Applicant |
| US2002/0178003(A1) | 2002-11-01 | Gehrke et al. | Applicant |
| US2003/0022126(A1) | 2003-01-01 | Buchalla | Applicant |
| US2003/0107739(A1) | 2003-06-01 | Lehmann et al. | Applicant |
| US2003/0109055(A1) | 2003-06-01 | Lehmann et al. | Applicant |
| US2003/0152307(A1) | 2003-08-01 | Drasek et al. | Applicant |
| US2004/0174914(A1) | 2004-09-01 | Fukatsu | Applicant |
| US2004/0240037(A1) | 2004-12-01 | Harter | Applicant |
| US2005/0111500(A1) | 2005-05-01 | Harter et al. | Applicant |
| US2005/0133691(A1) | 2005-06-01 | Doppke et al. | Applicant |
| US2006/0223032(A1) | 2006-10-01 | Fried | Applicant |
| US2006/0245461(A1) | 2006-11-01 | Islam | Applicant |
| US2006/0268393(A1) | 2006-11-01 | Islam | Applicant |
| US2006/0283931(A1) | 2006-12-01 | Polli et al. | Applicant |
| US2007/0021670(A1) | 2007-01-01 | Mandelis et al. | Applicant |
| US2007/0078348(A1) | 2007-04-01 | Holman | Applicant |
| US2008/0105665(A1) | 2008-05-01 | Kondo | Applicant |
| US2009/0028193(A1) | 2009-01-01 | Islam | Applicant |
| US2009/0204110(A1) | 2009-08-01 | Islam | Applicant |
| US2010/0046067(A1) | 2010-02-01 | Fermann et al. | Applicant |
| US2010/0322490(A1) | 2010-12-01 | Pan | Applicant |
| US2010/0331637(A1) | 2010-12-01 | Ting | Applicant |
| US2011/0143364(A1) | 2011-06-01 | Kim | Applicant |
| US2011/0267688(A1) | 2011-11-01 | Kleppe et al. | Applicant |
| US2011/0282167(A1) | 2011-11-01 | Ridder et al. | Applicant |
| US2012/0013722(A1) | 2012-01-01 | Wong | Applicant |
| US2012/0239013(A1) | 2012-09-01 | Islam | Applicant |
| US2013/0274569(A1) | 2013-10-01 | Islam | Applicant |
| US2013/0327966(A1) | 2013-12-01 | Fidler et al. | Applicant |
| US2014/0078510(A1) | 2014-03-01 | Rubio Guivernau et al. | Applicant |
| DE102010012987(A1) | 2010-10-01 | Applicant | |
| EP1148666 | 2001-10-01 | Applicant | |
| WO9715240 | 1997-05-01 | Applicant | |
| WO97049340 | 1997-12-01 | Applicant | |
| WO1150959 | 2001-07-01 | Applicant | |
| WO200189362 | 2001-11-01 | Applicant | |
| WO200227640 | 2002-04-01 | Applicant | |
| WO200228123 | 2002-04-01 | Applicant | |
| WO2005013843(A2) | 2005-02-01 | Applicant | |
| WO2007061772(A2) | 2007-05-01 | Applicant | |
| WO2009130464(A1) | 2009-10-01 | Applicant | |
| WO2013012938 | 2013-01-01 | Applicant |
Non-Patent Literature (176)
- Istepanian, Robert H., “The Comparative Performance of Mobile Telemedical Systems based on the IS-54 and GSM Cellular Telephone Standards”; Journal of Telemedicine and Telecare 1999; pp. 97-104.Applicant
- Aris, Ishak Bin, “An Internet-Based Blood Pressure Monitoring System for Patients”; Journal of Telemedicine and Telecare 2001; pp. 51-53.Applicant
- Sun, Y., C.F. Booker, S. Kumari, R.N. Day, M. Davidson, A. Periasamy, “Characterization of an orange acceptor fluorescent protein for sensitized spectral fluorescence resonant energy transfer microscopy using a white-light laser,” Journal of Biomedical Optics, vol. 14, No. 5, paper 054009 (2009).Applicant
- Borlinghaus, R., “Colours Count: how the challenge of fluorescence was solved in confocal microscopy,” in Modern Research and Educational Topics in Microscopy, A. Mendez-Vilas and J. Diaz, eds, pp. 890-899, Formatex (2007).Applicant
- Borlinghaus, R., “The White Confocal: Continuous Spectral Tuning in Excitation and Emission,” in Optical Fluorescence Microscopy, A. Diaspro (Ed), Chapter 2, pp. 37-54, ISBN 978-3-642-15174-3, Springer-Verlag, Berlin (2011).Applicant
- Borlinghaus, R.T., L. Kuschel, “White Light Laser: The Ultimate Source for Confocal Microscopy,” http://www.leica-microsystems.com/science-lab/white-light-laser (Jun. 27, 2012).Applicant
- Ziegler, U., A.G. Bittermann, M. Hoechli, “Introduction to Confocal Laser Scanning Microscopy (LEICA),” www.zmb.unizh.ch, May 29, 2013.Applicant
- Ooi ET, Zhang XQ, Chen JH, Soh PH, Ng K, Yea JH, “Non-invasive glucose measurement using multiple laser diodes,” Optical Diagnostic and Sensing VII, edited by Gerard L. Cote, Alexander V. Priezzhev, Proc. of SPIE vol. 6445, 64450K , (2007).Applicant
- Schulz, I., J. Putzger, A. Niklas, M. Brandt, A. Jager, A. Hardt, S. Knorzer, K.A. Hiller, S. Loffler, G. Schmalz, S.N. Danilov, S. Giglberger, M. Hirmer, S.D. Ganichev, G. Monkman, “PPG signal acquisition and analysis on in vitro tooth model for dental pulp vitality assessment,” ARC Submission 16, (2012).Applicant
- Drexler, C., Hirmer, M., Danilov, S., Giglberger, S., Putzger, J., Niklas, A., Jager, A., Hiller, K., Loffler, S., Schmalz, G., Redlich, B., Schulz, I., Monkman, G., Ganichev, S. “Infrared spectroscopy for clinical diagnosis of dental pulp vitality.” Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2012 37th International Conference on. IEEE (2012).Applicant
- Hirmer, Marion, Danilov, Sergey, Giglberger, Stephan, Putzger, Jurgen, Niklas, Andreas, Jager, Andreas, Hiller, Karl-Anton, Loffler, Susanne, Schmalz, Gottfried, Redlich, Britta, Schulz, Irene, Monkman, Gareth, Ganichev, Sergey. “Spectroscopic Study of Human Teeth and Blood from Visible to Terahertz Frequencies for Clinical Diagnosis of Dental Pulp Vitality.” Journal of Infrared, Millimeter, and Terahertz Waves 33.3 (2012): 366-375.Applicant
- Na, J, J.H. Baek, S.Y. Ryu, C. Lee, B.H. Lee, “Tomographic imaging of incipient dental-caries using optical coherence tomography and comparison with various modalities,” Optical Review, vol. 16, No. 4, pp. 426-431 (2009).Applicant
- Robert S. Jones et al.; Near-Infrared Transillumination At 1310-nm for the Imaging of Early Dental Decay; vol. 11, No. 18; Optics Express 2259; Sep. 8, 2003.Applicant
- Extended European Search Report for European Application No. 13867892.5 dated Jul. 22, 2016.Applicant
- Extended European Search Report for European Application No. 13867874.3 dated Jul. 15, 2016.Applicant
- Vinay V. Alexander et al.; Modulation Instability High Power All-Fiber Supercontinuum Lasers and Their Applications; Optical Fiber Technology 18; 2012; pp. 349-374.Applicant
- Final Office Action dated Oct. 21, 2016 for U.S. Appl. No. 14/875,709.Applicant
- International Search Report and Written Opinion for International Application No. PCT/US2013/075736 dated Apr. 7, 2014.Applicant
- International Preliminary Report on Patentability for International Application No. PCT/US2013/075736 dated Jul. 9, 2015.Applicant
- Hori, Takashi, et al., “Flatly broadened, wideband and low noise supercontinuum generation in highly nonlinear hybrid fiber”, Optics Express, vol. 12, No. 2, Jan. 26, 2004, pp. 317-324.Applicant
- Wadsworth, W. J., et al., “Supercontinuum and four-wave mixing with Q-switched pulses in endlessly single-mode photonic crystal fibres”, Optics Express, vol. 12, No. 2, Jan. 26, 2004, pp. 299-309.Applicant
- Hilligsoe, Karen Marie, et al., “Supercontinuum generation in a photonic crystal fiber with two zero dispersion wavelengths”, Optics Express, vol. 12, No. 6, Mar. 22, 2004, pp. 1045-1054.Applicant
- Venugopalan, V., “Optical Society of America Biomed Topical Meeting Tutorial on Tissue Optics”, Apr. 27, 2004, pp. 1-32.Applicant
- Slusher, Richart E., et al., “Large Raman gain and nonlinear phase shifts in high-purity As2So3 chalcogenide fibers”, J. Opt. Soc. Am. B, vol. 21, No. 6, Jun. 2004, pp. 1146-1155.Applicant
- Leon-Saval, S. G., et al., “Supercontinuum generation in submicron fibre waveguides”, Optics Express, vol. 12, No. 13, Jun. 28, 2004, pp. 2864-2869.Applicant
- Nicholson, J. W., et al., “High power, single mode, all-fiber source of femtosecond pulses at 1550 nm and its use in supercontinuum generation”, Optics Express, vol. 12, No. 13, Jun. 28, 2004, pp. 3025-3034.Applicant
- Genty, G., et al., “Enhanced bandwidth of supercontinuum generated m microstructured fibers”, Optics Express, vol. 12, No. 15, Jul. 26, 2004, pp. 3471-3480.Applicant
- Champert, Pierre-Alain, et al., “White-light supercontinuum generation in normally lispersive optical fiber using original multi-wavelength pumping system”, Optics Express, vol. 12, No. 19, Sep. 20, 2004, pp. 4366-4371.Applicant
- Nicholson, J. W., “Supercontinuum generation in ultraviolet-irradiated fibers”, Optics Letters, vol. 29, No. 20, Oct. 15, 2004, pp. 2363-2365.Applicant
- Hori, Takashi, et al., “Experimental and numerical analysis of widely broadened supercontinuum generation in highly nonlinear dispersion-shifted fiber with a femtosecond pulse”, J. Opt. Soc. Am. B, vol. 21, No. 11, Nov. 2004, pp. 1969-1980.Applicant
- Demircan, Ayhan, et al., “Supercontinuum generation by the modulation instability”, Optics Communications 244, 2005, pp. 181-185.Applicant
- Papemyi, S. B., et al., “Sixth-Order Cascaded Raman Amplification”, OFC/NFOEC, 2005, 3 pages.Applicant
- Tanaka, Keiji, “Optical nonlinearity in photonic glasses”, Journal of Materials Science: Materials in Electronics 16, 2005, pp. 633-643.Applicant
- Westbrook, Paul S., “Improved Supercontinuum Generation Through UV Processing of Highly Nonlinear Fibers”, Journal of Lightwave Technology, vol. 23, No. 1, Jan. 2005, pp. 13-18.Applicant
- Abeeluck, Akheelesh K., et al., “Continuous-wave pumping in the anomalous- and normal dispersion regimes of nonlinear fibers for supercontinuum generation”, Optics Letters, vol. 30, No. 1, Jan. 1, 2005, pp. 61-63.Applicant
- Kutz, J. Nathan, et al., “Enhanced Supercontinuum Generation through Dispersion-Management”, Optics Express, vol. 13, No. 11, May 30, 2005, pp. 3989-3998.Applicant
- Lee, Ju Han, et al., “Experimental performance comparison for various continuous-wave supercontinuum schemes: ring cavity and single pass structures”, Optics Express, vol. 13, No. 13, Jun. 27, 2005, pp. 4848-4853.Applicant
- Saliminia, A., et al., “Ultra-broad and coherent white light generation in silica glass by focused femtosecond pulses at 1.5pm”, Optics Express, vol. 13, No. 15, Jul. 25, 2005, pp. 5731-5738.Applicant
- Takushima, Yuichi, High average power, depolarized super-continuum generation using a 1.55-um ASE noise source, Optics Express, vol. 13, No. 15, Jul. 25, 2005, pp. 5871.-5877.Applicant
- Travers, J. C., et al., “Extended continuous-wave supercontinuum generation in a low-water-loss holey fiber”, Optics Letters, vol. 30, No. 15, Aug. 1, 2005, pp. 1938-1940.Applicant
- Kobtsev, Serguei M., et al., “Modelling of high-power supercontinuum generation in highly nonlinear, dispersion shifted fibers at CW pump”, Optics Express, vol. 13, No. 18, Sep. 5, 2005, pp. 6912-6918.Applicant
- Falk, Peter, et al., “Supercontinuum generation in a photonic crystal fiber with two zero-dispersion wavelengths tapered to normal dispersion at all wavelengths”, Optics Express, vol. 13, No. 19, Sep. 19, 2005, pp. 7535-7540.Applicant
- Tombelaine, Vincent, et al., “Ultra wide band supercontinuum generation in air-silica holey fibers by SHG-induced modulation instabilities”, Optics Express, vol. 13, No. 19, Sep. 19, 2005, pp. 7399-7404.Applicant
- Hazen, K.H., M.A. Arnold, G.W. Small, “Measurement of glucose and other analytes in undiluted human serum with near-infrared transmission spectroscopy,” Analytica Chimica Acta, vol. 371, pp. 255-267 (1998).Applicant
- Malin, S.F., T.L. Ruchti, T.L. Blank, S.N. Thennadil, S.L. Monfre, “Noninvasive prediction of glucose by near-infrared diffuse reflectance spectroscopy,” Clinical Chemistry, vol. 45, No. 9, pp. 1651-1658 (1999).Applicant
- Thennadil, S.N., J.L. Rennert, B.J. Wenzel, K.H. Hazen, T.L. Ruchti, M.B. Block, “Comparison of glucose concentration in interstitial fluid, and capillary and venous blood during rapid changes in blood glucose levels,” Diabetes Technology & Therapeutics, vol. 3, No. 3, pp. 357-365 (2001).Applicant
- Troy, T.L., S.N. Thennadil, “Optical properties of human skin in the near infrared wavelength range of 1000 to 2200nm,” Journal of Biomedical Optics, vol. 6, No. 2, pp. 167-176, (2001).Applicant
- Blank, T.B., T.L. Ruchti, A.D. Lorenz, S.L. Monfre, M.R. Makarewicz, M. Mattu, K.H. Hazen, “Clinical results from a non-invasive blood glucose monitor,” Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, A.V. Priezzhev and G.L. Cote, Editors, Proceedings of SPIE, vol. 4624, pp. 1019 (2002).Applicant
- Yeh, S-J, C.F. Hanna, O.S. Khalil, “Monitoring blood glucose changes in cutaneous tissue by temperature-modulated localized reflectance measurements,” Clinical Chemistry, vol. 49, No. 6, pp. 924-934 (2003).Applicant
- Marbach, R., T. Koschinsky, F.A. Gries, H.M. Heise, “Noninvasive blood glucose assay by near-infrared diffuse reflectance spectroscopy of the human inner lip,” Applied Spectroscopy, vol. 47, No. 7, pp. 875-881 (1993).Applicant
- Enejder, A.M.K., T.G. Scecina, J. Oh, M. Hunter, W.C. Shih, S. Sasic, G.L. Horowitz, M.S. Feld, “Raman spectroscopy for noninvasive glucose measurements,” Journal of Biomedical Optics, vol. 10, No. 3, 031114 (2005).Applicant
- Olesberg, J.T., L. Liu, V.V. Zee, M.A. Arnold, “In vivo near-infrared spectroscopy of rat skin tissue with varying blood glucose levels,” Analytic Chemistry, vol. 78, No. 1, pp. 215-223 (2006).Applicant
- Olesberg, J.T., M.A. Arnold, C. Mermelstein, J. Schmitz, J. Wagner, “Tunable laser diode system for noninvasive blood glucose measurements,” Applied Spectroscopy, vol. 59, No. 12, pp. 1480-1484 (2005).Applicant
- Harman-Boehm, I. A. Gal, A.M. Raykhman, J.D. Zahn, E. Naidis, Y. Mayzel, “Noninvasive glucose monitoring: a novel approach,” Journal of Diabetes Science and Technology, vol. 3, No. 2 pp. 253-260 (2009).Applicant
- Kim-K.D. G.S. Son, S.S. Lim, S.S. Lee, “Measurement of glucose level exploiting a relative optical absorption at discrete probe wavelengths,” Japanese Journal of Applied Physics, vol. 48, 077001 (2009).Applicant
- Smith, J.L., “The Pursuit of Noninvasive Glucose: Hunting the Deceitful Turkey,” 2nd Edition, pp. 1-141 (2011).Applicant
- Pezzaniti, J.L., T.W. Jeng, L. McDowell, G.M. Oosta, “Preliminary investigation of near-infrared spectroscopic measurements of urea, creatinine, glucose, protein and ketone in urine,” Clinical Biochemistry, vol. 34, pp. 239-246 (2001).Applicant
- Lussi, A., R. Hibst, R. Paulus, “Diagnodent: An optical method for caries detection,” Journal of Dental Research, vol. 83, special issue C, pp. C80-C83 (2004).Applicant
- Reese, E.L, E.E. Fisher, D.A. Horowitz, “Photoelectric densitometry of the circulation of the human dental pulp,” The Journal of the Baltimore College of Dental Surgery, vol. 26, No. 1, pp. 6-18 (1971).Applicant
- Zakian, C., I. Pretty, R. Ellwood, “Near-infrared hyperspectral imaging of teeth for dental caries detection,” Journal of Biomedical Optics, vol. 16, No. 6, 064047 (2009).Applicant
- Belikov, A.V., A.V. Skripnik, K.V. Shatilova, “Study of the dynamics of the absorption spectra of human tooth enamel and dentine under heating and ablation by submillisecond pulse radiation of an erbium laser with a generation wavelength of 2.79 um,” Optics and Spectroscopy, vol. 109, No. 2, pp. 211-216 (2010).Applicant
- Karlsson, L. “Caries detection methods based on changes in optical properties between healthy and carious issue,” International Journal of Dentistry, vol. 2010, Article ID 270729, 9 pages (2010).Applicant
- Fried, D. M. Staninec, C.L. Darling, “Near-infrared imaging of dental decay at 1310nm,” Journal of Laser Dentistry, vol. 18, No. 1, pp. 8-16 (2010).Applicant
- Burmen, M. P. Usenik, A. Fidler, F. Pernus, B. Likar, “A construction of standardized near infrared hyper-spectral teeth database—a first step in the development of reliable diagnostic tool for quantification and early detection of caries,” Lasers in Dentistry XVII, edited by P. Rechmann, D. Fried, Proceedings of SPIE, vol. 7884, Paper 78840E (2011).Applicant
- Maia, A., L. Karlsson, W. Margulis, A. Gomes, “Evaluation of two imaging techniques: near-infrared transillumination and dental radiographs for the detection of early approximal enamel caries,” Dentomaxillofacial Radiology, vol. 40, pp. 429-433 (2011).Applicant
- Chung, S., D. Fried, M. Staninec, C.L. Darling, “Multispectral near-IR reflectance and transillumination imaging of teeth,” Biomedical Optics Express, vol. 2, No. 10, pp. 2804-2814 (2011).Applicant
- Chung, S., D. Fried, M. Staninec, C.L. Darling, “Near infrared imaging of teeth at wavelengths between 1200 and 1600nm,” Proceedings of the Society of Photo Optical Instrument Engineering, paper 7884 (2011).Applicant
- Staninec, M., S.M. Douglas, C.L. Darling, K. Chan, H. Kang, R. C. Lee, D. Fried, “Nondestructive clinical assessment of occlusal caries lesions using near-IR imaging methods,” Lasers in Surgery and Medicine, vol. 43, No. 10, pp. 951-959 (2011).Applicant
- Nishizawa, N., “Generation and application of high-quality supercontinuum sources,” Optical Fiber Technology, vol. 18, pp. 394-402 (2012).Applicant
- Islam, M. N., et al., “Broad bandwidths from frequency-shifting solitons in fibers”, Optics Letters, vol. 14, No. 7, Apr. 1, 1989, pp. 370-372.Applicant
- Islam, M. N., et al., “Femtosecond distributed soliton spectrum in fibers”, J. Opt. Soc. Am. B, vol. 6, No. 6, Jun. 1989, pp. 1149-1158.Applicant
- Busse, Lynda E., et al., “Design Parameters for Fluoride Multimode Fibers”, Journal of Lightwave Technology, vol. 9, No. 7, Jul. 1991, pp. 828-831.Applicant
- Wuthrich, Stefan, et al., “Optical damage thresholds at 2.94 um in fluoride glass fibers”, Applied Optics, vol. 31, No. 27, Sep. 20, 1992, pp. 5833-5837.Applicant
- Inoue, H., et al., “Computer simulation of the vibrational spectra and properties of fluoride glasses based on ZrF4”, Journal of Non-Crystalline Solids, vol. 161, 1993, pp. 118-122.Applicant
- Mizunami, Toru, et al., “Gain saturation characteristics of Raman amplification in silica and fluoride glass optical fibers”, Optics Communications 97, 1993, pp. 74-78.Applicant
- Desthieux, B., et al., “111 kW (0. 5 mJ) pulse amplification at 1.5 um using a gated cascade of three erbium-doped fiber amplifiers,” Appl. Phys. Lett. vol. 63, Aug. 2, 1993, pp. 586-588.Applicant
- Edwards, Glenn, et al., “Tissue ablation by a free-electron laser tuned to the amide II band”, Nature, vol. 371, Sep. 29, 1994, pp. 416-419.Applicant
- Borrelli, N. F., et al., “Resonant and non-resonant effects in photonic glasses”, Journal of Non-Crystalline Solids 185, 1995, pp. 109-122.Applicant
- Asobe, Masaki, et al., “Third-order nonlinear spectroscopy in As2S3 chalcogenide glass fibers”, J. Appl. Phys. 77 (11), Jun. 1, 1995, pp. 5518-5523.Applicant
- Jarman, Richard H., “Novel optical fiber lasers”, Current Opinion in Solid State and Materials Science, 1996, pp. 199-203.Applicant
- Iatridis, James C., et al., “Is the Nucleus Pulposus a Solid or a Fluid? Mechanical Behaviors of the Nucleus Pulposus of the Human Intervertebral Disc”, Spine, vol. 21(10), May 15, 1996, pp. 1174-1184.Applicant
- Asobe, Masaki, “Nonlinear Optical Properties of Chalcogenide Glass Fibers and Their Application to All-Optical Switching”, Optical Fiber Technology, vol. 3, Article No. OF970214, 1997, pp. 142-148.Applicant
- Smektala, F., et al., “Chalcogenide glasses with large non-linear refractive indices”, Journal of Non-Crystalline Solids 239, 1998, pp. 139-142.Applicant
- Hamilton, James D., et al., “High Frequency Ultrasound Imaging with Optical Arrays”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 45, No. 1, Jan. 1998, pp. 216-235.Applicant
- Hamilton, James D., et al., “High Frequency Ultrasound Imaging Using an Active Optical Detector”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 15, No. 3, May 1998, pp. 719-727.Applicant
- Nowak, G. A., et al., “Low-power high-efficiency wavelength conversion based on modulational instability in high-nonlinearity fiber,” Optics Letters, vol. 23, No. 12, Jun. 15, 1998, pp. 936-938.Applicant
- Cardinal, T., et al., “Non-linear optical properties of chalcogenide glasses in the system As-S-Se”, Journal of Non-Crystalline Solids 256 & 257, 1999, pp. 353-360.Applicant
- Lucas, Jacques, “Infrared glasses”, Current Opinion in Solid State & Materials Science 4, 1999. pp. 181-187.Applicant
- Sanghera, J. S., et al., Active and passive chalcogenide glass optical fibers for IR applications: a review, Journal of Non-Crystalline Solids 256 & 257, 1999, pp. 6-16.Applicant
- Nishida, Yoshiki, et al., “Reliability of Fluoride Fiber Module for Optical Amplifier Use”, IEEE Photonics Technology Letters, vol. 11, No. 12, Dec. 1999, pp. 1596-1598.Applicant
- Nowak, George A., et al., “Stable supercontinuum generation in short lengths of conventional dispersion-shifted fiber”, Applied Optics, vol. 38, No. 36, Dec. 20, 1999, pp. 7364-7369.Applicant
- Urban, J. P. G., et al., “The Nucleus of the Intervertebral Disc from Development to Degeneration” Amer. Zool., vol. 40, 2000, pp. 53-61.Applicant
- Hamilton, James D., et al., “High Frequency Optoacoustic Arrays Using Etalon Detection”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 47, No. 1, Jan. 2000, pp. 160-169.Applicant
- Ranka, Jinendra K., et al., “Visible continuum generation in air-silica microstructure optical fibers with anomalous dispersion at 800 nm”, Optics Letters, vol. 25, No. 1, Jan. 1, 2000, pp. 25-27.Applicant
- Boult, Maggi, et al., “Systematic Review of Percutaneous Endoscopic Laser Discectomy: Update and Re-appraisal”, Australian Safety and Efficacy Register of New Interventional Procedures—Surgical Report No. 5, Feb. 2000, 49 pages.Applicant
- Boult, Maggi, et aL, “Percutaneous Endoscopic Laser Discectomy”, Systematic Review, Aust. N.Z.J. Surg., vol. 70, Apr. 7, 2000, pp. 475-479.Applicant
- Camacho, Nancy P., et al., “FTIR Microscopic Imaging of Collagen and Proteoglycan in Bovine Cartilage,” Biopolymers (Biospectroscopy), vol. 62, 2001, pp. 1-8.Applicant
- Choi, Joon Y., et al, “Thermal, Mechanical, Optical, and Morphologic Changes in Bovine Nucleus Pulposus Induced by Nd:YAG (λ=1.32 um) Laser Irradiation”, Lasers in Surgery and Medicine, vol. 28, 2001, pp. 248-254.Applicant
- Hafez, M. I., et al., “The Effect of Irrigation on Peak Temperatures in Nerve Root, Dura, and Intervertebral Disc During Laser-Assisted Foraminoplasty”, Lasers in Surgery and Medicine, vol. 29, 2001, pp. 33-37.Applicant
- Jackson, Stuart D., et al., “Theory and numerical simulation of nth-order cascaded Raman fiber lasers”, J. Opt. Soc. Am. B, vol. 18, No. 9, Sep. 2001, pp. 1297-1306.Applicant
- Werle, Peter, et al., “Near- and mid-infrared laser-optical sensors for gas analysis”, Optics and Lasers in Engineering 37, 2002, pp. 101-114.Applicant
- Beck, Mattias, et al., “Continuous Wave Operation of a Mid-Infrared Semiconductor Laser at Room Temperature,” Science vol. 295, www.sciencemag.org, Jan. 11, 2002, pp. 301-305.Applicant
- Harbold, J. M., et al., “Highly nonlinear As—S—Se glasses for all-optical switching”, Optics Letters, vol. 27, No. 2, Jan. 15, 2002, pp. 119-121.Applicant
- Coen, Stephane, et al., “Supercontinuum generation by stimulated Raman scattering and parametric four-wave mixing in photonic crystal fibers”, J. Opt. Soc. Am. B, vol. 19, No. 4, Apr. 2002, pp. 753-764.Applicant
- Dudley, John M., et al., “Supercontinuum generation in air-silica microstructured fibers with nanosecond and femtosecond pulse pumping”, J. Opt. Soc. Am. B, vol. 19, No. 4, Apr. 2002, pp. 765-771.Applicant
- Harbold, Jeffrey M., et al., “Highly Nonlinear Ge—As—Se and.Ge—As—S—Se Glasses for All-Optical Switching”, IEEE Photonics Technology Letters, vol. 14, No. 6, Jun. 2002, pp. 822-824.Applicant
- Husakou, Anton V., et al, “Supercontinuum generation, four-wave mixing, and fission of iigher-order solitons in photonic-crystal fibers”, J. Opt. Soc. Am. B, vol. 19, No. 9, Sep. 2002, pp. 2171-2182.Applicant
- Wadsworth, William J., et al., “Supercontinuum generation in photonic crystal fibers and optical fiber tapers: a novel light source”, J. Opt. Soc. Am. B, vol. 19, No. 9, Sep. 2002, pp. 2148-2155.Applicant
- Kumar, V.V. Ravi Kanth, et al, “Extruded soft glass photonic crystal fiber for ultrabroad supercontinuum generation”, Optics Express, vol. 10, No. 25, Dec. 16, 2002, pp. 1520-1525.Applicant
- Edwards, Glenn S., et al., “Advantage of the Mark-III FEL for biophysical research and biomedical applications”, J. Synchrotron Rad. vol. 10, 2003, pp. 354-357.Applicant
- Nicholson, J. W., et al., “Pulsed and continuous-wave supercontinuum generation in highly nonlinear, dispersion-shifted fibers”, Applied Physics B 77, 2003, pp. 211-218.Applicant
- Sobol, Emil, et al., “Time-resolved, light scattering measurements of cartilage and cornea denaturation due to free electron laser radiation”, Journal of Biomedical Optics, vol. 8, No. 2, Apr. 2003, pp. 216-222.Applicant
- Nicholson, J. W., et al., “All-fiber, octave-spanning supercontinuum”, Optics Letters, vol. 28, No. 8, Apr. 15, 2003, pp. 643-645.Applicant
- Faralli, S., et al., “Impact of Double Rayleigh Scattering Noise in Distributed Higher Order Raman Pumping Schemes”, IEEE Photonics Technology Letters, vol. 15, No. 6, Jun. 2003, pp. 804-806.Applicant
- “New and Emerging Techniques—Surgical, Rapid Review, Laser Discectomy”, Australian Safety and Efficacy Register of New Interventional Procedures—Surgical, Jun. 2003, 12 pages.Applicant
- Avdokhin, A. V., et al, “Continuous-wave, high-power, Raman continuum generation in holey fibers”, Optics Letters, vol. 28, No. 15, Aug. 1, 2003, pp. 1353-1355.Applicant
- Mussot, Arnaud, et al., “Generation of a broadband single-mode supercontinuum in a conventional dispersion-shifted fiber by use of a subnanosecond microchip laser”, Optics Letters, vol. 28, No. 19, Oct. 1, 2003, pp. 1820-1822.Applicant
- Slusher, Richard, et al., “Highly nonlinear composite chalcogenide/polymer fibers”, OSA 2004, 1 page.Applicant
- Thongtrangan, Issada, et al., “Minimally invasive spinal surgery: a historical perspective”, Neurosurg. Focus, vol. 16, Article 13, Jan. 2004, pp. 1-10.Applicant
- Lee, Ju Han, et al., “Continuous-wave supercontinuum laser based on an erbium-doped fiber ring cavity incorporating a highly nonlinear optical fiber”, Optics Letters, vol. 30, No. 19, Oct. 1, 2005, pp. 2599-2601.Applicant
- Genty, G., et al., “Supercontinuum generation in large mode-area microstructured fibers”, Optics Express, vol. 13, No. 21, Oct. 17, 2005, pp. 8625-8633.Applicant
- Schreiber, T., et al., “Supercontinuum generation by femtosecond single and dual wavelength pumping in photonic crystal fibers with two zero dispersion wavelengths”, Optics Express, vol. 13, No. 23, Nov. 14, 2005, pp. 9556-9569.Applicant
- Travers, J. C., et al., “Extended blue supercontinuum generation in cascaded holey fibers”, Optics Letters, vol. 30, No. 23, Dec. 1, 2005, pp. 3132-3134.Applicant
- Hagen, C. L., et al., “Generation of a Continuum Extending to the Midinfrared by Pumping ZBLAN Fiber With an Ultrafast 1550-nm Source”, IEEE Photonics Technology Letters, vol. 18, No. 1, Jan. 1, 2006, pp. 91-93.Applicant
- Moon, Sucbei, et al., “Generation of octave-spanning supercontinuum with I550-nm amplified diode-laser pulses and a dispersion-shifted fiber”, Optics Express, vol. 14, No. 1, Jan. 9, 2006, pp. 270-278.Applicant
- Fedotova, O., et al., “Supercontinuum generation in planar rib waveguides enabled by anomalous dispersion”, Optics Express, vol. 14, No. 4, Feb. 20, 2006, pp. 1512-1517.Applicant
- Harrington, James A., “Infrared Fiber Optics”, OSA Handbook, vol. III, white paper, to be published by McGraw Hill, Undated, 13 pages.Applicant
- Aaviksoo, J., et al., “Observation of optical precursors at pulse propagation in GaAs”, Physical Review A, vol. 44, No. 9, Nov. 1, 1991, pp. R5353-R5356.Applicant
- Boppart, Stephen A., et al., “Imaging developing neural morphology using optical coherence tomography”, Journal of Neuroscience Methods 70, 1996, pp. 65-72.Applicant
- Boppart, Stephen A., et al., “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography”, Prec. Natl. Acad. Sci. USA, vol. 94, Apr. 1997, pp. 4256-4261.Applicant
- Tearney, Guillermo J., et al., “In vivo Endoscopic Optical Biopsy with Optical Coherence Tomography”, Science, New Series, vol. 276, Jun. 27, 1997, pp. 2037-2039.Applicant
- de Boer, Johannes F., et al., “Imaging thermally damaged tissue by polarization sensitive optical coherence tomography”, Optics Express 212, vol. 3, No. 6, Sep. 14, 1998, pp. 212-218.Applicant
- Roggan, Andre, et al., “Optical Properties of Circulating Human Blood in the Wavelength Range 400-2500 NM”, Journal of Biomedical Optics, vol. 4, No. 1, Jan. 1999, pp. 36-46.Applicant
- de Boer, Johannes F., et al., “Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography”, Optics Letters, vol. 24, No. 5; Mar. 1, 1999, pp. 300-302.Applicant
- Rollins, Andrew M., et al., “Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design”, Optics Letters, vol. 24, No. 19, Oct. 1, 1999, pp. 1358-1360.Applicant
- D'Amico, Anthony V., et al., “Optical Coherence Tomography As a Method for Identifying Benign and Malignant Microscopic Structures in the Prostate Gland”, Basic Science, Urology 55 (5), 2000, pp. 783-787.Applicant
- Li, Xingde, et al., “Imaging needle for optical coherence tomography”, Optics Letters, vol. 25, No. 20, Oct. 15, 2000, pp. 1520-1522.Applicant
- Oughstun, Kurt E., “Influence of precursor fields on ultrashort pulse autocorrelation measurements and pulse width evolution”, Optics Express, vol. 8, No. 8, Apr. 9, 2001, pp. 481-491.Applicant
- Kowalevicz, Andrew M., et al., “Ultrahigh resolution optical coherence tomography using a superluminescent light source” Optics Express 349, vol. 10, No. 7, Apr. 8, 2002, pp. 349-353.Applicant
- Povazay, B., et al., “Submicrometer axial resolution optical coherence tomography”, Optics Letters, vol. 27, No. 20, Oct. 15, 2002, pp. 1800-1802.Applicant
- Xie, T.-Q., et al., “Detection of tumorigenesis in urinary bladder with optical coherence tomography: optical characterization of morphological changes”, Optics Express, vol. 10, No. 24, Dec. 2, 2002, 2003, pp. 1431-1443.Applicant
- Seefeldt, Michael, et al., “Compact white-light source with an average output power of 2.4 Wand 900 nm spectral bandwidth”, Optics Communications 216, pp. 199-202.Applicant
- Wang, Yimin, et al., “Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber”, Optics Letters, vol. 28, No. 3, Feb. 1, 2003, pp. 182-184.Applicant
- Bizheva, K, et al., “Compact, broad-bandwidth fiberlaserforsub-2-pm axial resolution optical coherence tomography in the 1300-nm wavelength region,” Optics Letters, vol. 28, No. 9, May 1, 2003, pp. 707-709.Applicant
- Pan, Yingtian, et al., “Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage”, Journal of Biomedical Optics 8(4), Oct. 2003, pp. 648-654.Applicant
- Xie, Tuqiang, et al., “Endoscopic optical coherence tomography with a modified microelectromechanical systems mirror for detection of bladder cancers”, Applied Optics, vol. 42, No. 31, Nov. 1, 2003, pp. 6422-6426.Applicant
- Dubois, A., et al., “Three-dimensional cellular-level imaging using full-field optical coherence tomography”, Physics in Medicine and Biology, Phys. Med. Biol. 49, 2004, pp. 1227-1234.Applicant
- Park, Jesung, et al., “Analysis of birefringent image in the retinal nerve fiber layer by polarization sensitive optical coherence tomography”, Ophthalmic Technologies XIV, Proceedings of SPIE, vol. 5314, 2004, pp. 188-194.Applicant
- Unterhuber, A., et al., “Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography”, Physics in Medicine and Biology, Phys. Med. Biol. 49, 2004, pp. 1235-1246.Applicant
- Drexler, Wolfgang, “Ultrahigh-resolution optical coherence tomography”, Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 47-74.Applicant
- Schmitt, Joseph, et al., “Intravascular Optical Coherence Tomography Opens a Window Onto Coronary Artery Disease”, Optics & Photonics News, Feb. 2004, pp. 20-25.Applicant
- Nassif, N.A., et al., “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve”, Optics Express, vol. 12, No. 3, Feb. 9, 2004, pp. 367-376.Applicant
- Choi, Seung-Ho, et al., “Observation of Optical Precursors in Water”, Physical Review Letters, vol. 92, No. 19, May 14, 2004, pp. 193903-1-193903-3.Applicant
- Pierce, Mark C., et al., “Advances in Optical Coherence Tomography imaging for Dermatology”, Optical Coherence Tomography Advances, The Journal of Investigative Dermatology, Sep. 3, 2004, pp. 458-463.Applicant
- “State-Specific Trends in Chronic Kidney Failure—United States, 1990-2001”, Morbidity and Mortality Weekly Report, Department of Health and Human Services Centers for Disease Control and Prevention, vol. 53, No. 39, copied from internet: file://C:\Documents and Settings\eturlo\Desktop\State-Specific Trends in Chronic Kidney . . . Feb. 12, 2010, Oct. 8, 2004, pp. 918-920.Applicant
- I.B. Ads, A.A.E. Wagie, N.B. Mariun, A.B.E. Jammal, “An Internet-based blood pressure monitoring system for patients,” Journal of Telemedicine and Telecare, 2001, pp. 51-53.Applicant
- R.H. Istepanian, B. Woodward, P.A. Bales, S. Chen, B. Luk, “The comparative performance of mobile telemediCal systems based on the IS-54 and GSM cellular telephone standards,” Journal of Telemedicine and Telecare, 1999, pp. 97-104.Applicant
- Shaw, et al, IR Supercontinuum Generation in As—Se Photonic Crystal Fiber, Optical Society of America, Copyright 2005, 3 pages.Applicant
- PCT/US06/44451, Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration, dated Nov. 29, 2007, 12 pages.Applicant
- G.S. Edwards et al., “Free-electron-laser-based biophysical and biomedical instrumentation,” American Institute of Physics, vol. 74, No. 7, Jul. 2003, pp. 3207-3245.Applicant
- Computer Motion, Inc., “501(k) Summary-ZEUS® MicroWrist™ Surgical System and Accessories,” Sep. 24, 2002, 6 pages.Applicant
- Computer Motion, Inc. “HERMES™ O.R. Control Center—510(k) Summary of Safety and Effectiveness,” Oct. 11, 2002, 5 pages.Applicant
- K.M. Joos, et al. “Optic Nerve Sheath Fenestration with a Novel Wavelength Produced by the Free Electron Laser (FEL),” Lasers in Surgery and Medicine, 27: 2000,191-205.Applicant
- J. Sanghera, I. Aggarwal, “IR Fiber Optics at NRL,” undated, 10 pages.Applicant
- J. Sanghera, L.B. Shaw, I.D. Aggarwal, “Applications of chalcogenide glass optical fibers,” Academic of Science, 2003, pp. 1-11.Applicant
- B. Rigas, P.T.T. Wong, “Human Colon Adenocarcinoma Cell Lines Display Infrared Spectroscopic Features,” Cancer Research, Jan. 1, 1992, pp. 84-88.Applicant
- G. Edwards, et al., “Comparison of OPA and Mark-III FEL for Tissue Ablation at 6.45 Microns,” Department of Physics and Free Electron Laser Laboratory, Duke University, 2002, 7 pages.Applicant
- Glenn Edwards, “Biomedical and potential clinical applications for pulsed lasers operating near 6.45 um,” Society of Photo-Optical Instrumentation Engineers, 1995, 2 pages.Applicant
- Passat, “Solid-State Lasers and Optical Components,” Jul. 14, 2003, 5 pages.Applicant
- P.A. Thielen and L.B. Shaw, et al., “Small-core As—Se fiber for Raman amplification,” Optics Leti-Ers, vol. 28, No. 16, Aug. 15, 2003, 3 pages.Applicant
- R.Rox Anderson, et al., “Selective Photothermolysis: Precise Microsurgery by Selective Absorption of Pulsed Radiation,” Department of Dermatology, Harvard Medical School, Science, vol. 220, Apr. 29, 1983, 4 pages.Applicant
- U.S. Appl. No. 10/652,276, “System and Method for Voice Control of Medical devices,” by Mohammed N. Islam, abandoned (074036.0129) filed Aug. 29, 2003.Applicant
- U.S. Appl. No. 10/757,341, “System and Method for Voice Control of Medical Devices,” by Mohammed N. Islam, issued (074036.0132) filed Jan. 13, 2004.Applicant
- U.S. Appl. No. 12/206,432, “System and Method for Voice Control of Medical Devices,” by Mohammed N. Islam, pending (074036.0154) filed Sep. 8, 2008.Applicant
- U.S. Patent and Trademark Office, Office Action for U.S. Appl. No. 12/206,432, filed Sep. 8, 2008, Mohammed N. Islam, Date filed: Mar. 12, 2009.Applicant
- U.S. Patent and Trademark Office, Notice of Allowance and Fee(s) Due for U.S. Appl. No. 12/206,432, filed Sep. 8, 2008, Mohammed N. Islam, Date filed: Aug. 28, 2009.Applicant