Solid phase quenching systems

Patent Citations (56)

Non-Patent Literature (67)

• Bahnemann, “Inactivation of viruses in serum with binary ethyleneimine” J. Clin. Microbiol. 3:209-210 (1975).Applicant
• Bahnemann, “Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine” Vaccine 8:299-303 (1990).Applicant
• Bieniarz et al., “A facile, high-yielding method for the conversion of halides to mercaptans” Tetrahedron Lett. 34:939-942 (1993).Applicant
• Budowsky et al., “Inactivation of the phage MS2 infectivity by the action of ethyleneimines” Biorg. Khim. 11:989-991 (1985) (in Russian). English Abstract provided, 1 page.Applicant
• Budowsky and Zalesskaya, “Principles of selective inactivation of viral genome. V. Rational selection of conditions for inactivation of the viral suspension infectivity to a given extent by the action of B-propiolactone” Vaccine 9:319-325 (1991).Applicant
• Budowsky et al., “Principles of selective inactivation of the viral genome; dependence of the rate of viral RNA modification on the number of protonizable groups in ethyleneimine oligomer” Vaccine Res. 5:29-39 (1996).Applicant
• Creech et al., “Antitumor and mutagenic properties of a variety of heterocyclic nitrogen and sulfur mustards” Med. Chem. 15:739-746 (1972).Applicant
• Dermer and Ham, Ethyleneimine And Other Aziridines, Acad. Press, NY—London (1969), pp. 249-285.Applicant
• Earley et al., “Reactions of ethylenimines. IX. The mechanisms of ring openings of ethylenimines in acidic solutions” J. Am. Chem. Soc. 80:3458-3462 (1958).Applicant
• Hagen et al., “Chemical modification of polystyrene introduction of sulfinate and sufone functionalities” Polymer Bull. 5:111-116 (1981).Applicant
• King, “Evaluation of different methods of inactivation of newcastle disease virus and avian influenza virus in egg fluids and serum” Avian Diseases 35:505-514 (1991).Applicant
• Kochetkov and Budowsky eds., Organic Chemistry of Nucleic Acids, Part A, Plenum Press, London-New York, pp. 48-55 (1972).Applicant
• Kostyanovskii et al., “Oligomers of azridines and N-beta-azridinoethylamides,” Bull. Acad. Sci. USSR, Div. Chem. Sci. 37:2315-2325 (1989). (Translated from IzvestiyaAkademi Nauk SSSR, Seriya Khimicheskaya 11:2566-2575.).Applicant
• Prodouz et al., “Inhibition of merocyanine 540-mediated photosensitization of platelets and viruses” Transfusion 31:415-422 (1991).Applicant
• Race et al., “An experimental chemically inactivated HIV-1 vaccine induces antibodies that neutralize homologous and heterologous viruses” Vaccine 13:54-60 (1995).Applicant
• Tanirbergenov et al., “Regularities of mutagenic and toxic effects of ethyleneimine and its oligomers. A comparative study in the automated system SOS-chromotest and in standard bacterial test systems” Genetika 24:763 (1988) (in Russian). English translation provided, 5 pages.Applicant
• Thanei-Wyss, “Interaction of quaternary ammonium compounds with acetylcholinesterase: characteristics of the active site” Eur. J. Pharmacol., Mol. Pharmacol. Sect. 172:165-173 (1989).Applicant
• Twomey et al., “Structure and immunogenicity of experimental foot-and-mouth disease and poliomyelitis” Vaccine 13:1603-1610 (1995).Applicant
• Van Etten and Dolhum, “Effects of hydrogen-bond formation by phenols on the conformational equilibrium of trans-1,2-dimethyl-3-isopropylaziridine” J. Org. Chem. 33:3904-3907 (1968).Applicant
• Wagner et al., “Approaches to the reduction of viral infectivity in cellular blood components and single donor plasma” Transfusion Med. Rev. 5:18-32 (1991).Applicant
• Ackerman et al., “INACTINE™-A Potent and Selective Method for Inactivating Viruses in Contaminated Blood Products,” Vox Sanguinis 74(S1) 1305 (1998).Applicant
• Ackerman, et al., “INACTINE™-A Viral Inactivation Technology for Reducing the Infectivity of Plasma-Derived Proteins,” Abstract presented at the 5th Annual Blood Safety and Screening Conference, McLean , VA, Feb. 22, 1999.Applicant
• Amor et al., “Use of N-Acetylethyleneimine [AEI] for the Inactivation of Semliki Forest Virus In Vitro,” Journal of Medical Virology 19:367-376 (1986).Applicant
• Budowsky, “Problems and Prospects for Preparation of Killed Antiviral Vaccines,” Advances in Virus Research 39:255-290 (1991).Applicant
• Edson, “INACTINE™-An Inactivation Technology for Reducing the Viral Infectivity of Plasma-Derived Proteins and Red Blood Cells,” Abstract from the IBC 2nd International Symposium on Viral Clearance, Jun. 25, 1998.Applicant
• Edson et al., “INACTINE™-A Viral Inactivation Technology for Reducing the Infectivity of Plasma-Derived Proteins,” Transfusion 38 (10S):75S S277 (1998).Applicant
• Hassanain, “Preliminary Findings for an Inactivated African Horsesickness Vaccine Using Binary Ethyleneimine,” Revue Elev. Med. vet. Pays trop., 45(3-4):231-234 (1992).Applicant
• Lobastov, “Use of Ethylenimine Dimer for the Inactivation of Infectious Rhinotracheitis Virus of Cattle,” Probl. Virusol., Mol. Biol. Gistol. S-kh. Zhivotn. pp. 4-6 (1983) translation attached.Applicant
• Zalesskaya, “Inactivation of Viral Genome by Beta-Propiolactone and Ethyleneimines Using the Bacteriophage MS-2 as an Example,” Russian State Library, Moscow, Russia, 1988 translation attached.Applicant
• Zhang et al., “INACTINE™-A Method for Viral Inactivation in Red Blood Cell Concentrate,” Transfusion 38 (10S):75S S279 (1998).Applicant
• Atwell, G. J. et al., Synthesis, DNA Interactions and Biological Activity of DNA Minor Groove Targeted Polyberizamide-linked Nitrogen Mustards, Bloorg Med. Client. 1995 Jun.; 3(6):679-91.Applicant
• Briel, S. et al Identification of New Aqueous Chemical Degradation Products of Isophosphoramide Mustard J Pharm Biomed Anal. 2001 Jun; 25 (3-4): 669-78.Applicant
• Brown, F. et al. A Universal Virus Inactivant for Decontaminating Blood and Biopharmaceutical Products Biologicals (1998) 26, 39-47.Applicant
• Burrage, et al. “Inactivation of viruses by Aziridines”, Advances in Transfusion Safety. Dev. Biol. Basel, Karger, 1999, vol. 102, pp. 131-139.Applicant
• Charache, S. et al.. Evaluation of Extracorporeal Alkylation of Red Cells as a Potential Treatment for Sickle Cell Anemia, Blood 1976; 47(3):481-88.Applicant
• Danao, T. et al., Nitrogen Mustard as Induction Therapy for Rheurnatoid Arthritis: Clinical and Immunologic Effects. J. Rheum. 1992 19:1683-86.Applicant
• Drake, M.E. et al., Effect of Nitrogen Mustard on Virus of Serum Heptitiis in Whole Blood. Proc. of Soc. Exp. Rio. Med. 1952(80)310-13.Applicant
• Ferguson, L.R. et al.. DNA-directed Aniline Mustards with High Selectivity for Adenine or Guanine Bases: Mutagenesis in a variety of Salmonella Tpyhimurium Strains Differing in DNA-Repair Capability,′ Mutant Res. 1994 Apr.; 321(1-2):27-34.Applicant
• Ferguson, L.R. et cal.. Bacterial Mutagenicity Studies of DNA-Intercalating Aniline Mustards: an Insight Into the Mode of Action of a Class of Anti-Tumor Drugs, Anticancer Drug Des. 1989 Oct.; 4(3):209-19.Applicant
• Fries, K.M. et al 31P NMR and Chloride Ion Kinetics of Alkylating Monoester Phosphoramidates J. Med. Chem 1991 Feb; 34(2): 565-9.Applicant
• Logrippo, G.A. et al.. Chemical and Combined Methods for Plasma Sterilization., 6th Congress of the Int'l Soc. of′Blood Trans., 1958, pp. 225-230.Applicant
• Gourdie T.A. et al.. Synthesis and Evaluation of DNA-targeted Spatially Separated Bis(Aniline Mustards) as Potential Alkylating Agents with Enhances DNA Cross-linking Capability, J. Med. Chem. 1991 Jan; 34(1):240-8.Applicant
• Gravatt, G.L. et al., DNA-Directed Alkylating Agents 4. 4-Anilinoduinoline-Based Minor Groove Directed Aniline Mustards, J. Med Chem 1991, 34(5):1552-60.Applicant
• Gravatt, G.L. et al., DNA-directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Tumor Groove-targeted Aniline Mustard Analogues of Pibenzimol, J. Med. Chem.. 1994 Dec. 9; 37(25): 4338-45.Applicant
• Griffin M.T. et al Kinetics of Activation and in Vivo Muscarinic Receptor Binding of N-(2-bromoethyl)-4-Piperidinyl Diphenylacetate: an Analog of 4-DAMP Mustard J. Pharmacol Exp Ther 1993 Jul; 266(1) 301-5.Applicant
• Hamza, A. Quantum Molecular Modeling of the Interaction Between Guanine and Alkylating Agents Nrogen Mustards, J. Med Chem 1991, 34(5):1552-60.Applicant
• Hartman, F.W. et al., Preparation and Sterilization of Blood Plasma. ProcApplicant
• Hartman, F.W. et al.. On the Chemical Sterilization of Blood and Blood Plasma. Proc. of Socc.. Exp. Bio. Med. 1949;70:248-54.Applicant
• Hartman, F.W., et al.. Four-Year Study Concerning the Inactivation of Viruses in Blood and Plasma, Presented at the 55th Annual Meeting of the American Gastroenterological Association, San Francisco, California, Jun. 1954.Applicant
• Hemminki, K. DNA Adducts of Nitrogen Mustards and Ethyleneimines DNA Adducts: Identification and Biological Significance, IARC Scientific Publications No. 125, Editors: Hemminki, et al., 1994, 99. 313-321.;.Applicant
• Hemmiki, K. Reactions of Nitrogen Mustards with DNA IARC Sci. Publ 1986; (78):55-70.Applicant
• Knorre, D.G. et al.. Reactive Derivatives of Oligonucleotides as Potential Antiviral Drugs, Problems of Virology, 1985, No. 5, pp. 524-′?.Applicant
• Kohn, K.W. et al Mechanisms of DNA Sequence Selective Alkylation of Guanine-N7 Positions by Nitrogen Mustards Biochem Pharmacol 1988 May 1; 37(9): 1799-800.Applicant
• Lee, M et al., In Vitro Cytotoxicity of GC Sequence Directed Alkylating Agents Related to Distamycin, J. Med.. Cheer, 1993, Apr. 2; 36(7)863-70.Applicant
• Mattes, W.B. et al., GC-rich Regions in Genomes as Targets for DNA Alkylation, Carcinogenesis 1988; 9(11):2065-72.Applicant
• Prakash, A.S. et al., Differences in Sequence Selectivity of DNA Alkylation by Isomeric Intercalating Aniline Mustards, Chem. Biol. Interact. 1990; 76(23):241-8.Applicant
• Price, C.C. et al Relative Reactivities for Monofunctional Nitrogen Mustard Alkylation of Nucleic Acid Components Biochim Biophys Acta 1968 Sep 24; 166(2):327-59.Applicant
• Roth, E.F. Jr. et al., Metabolic Effects of Antisickling Amounts of Nitrogen and Nor-N itrogen Mustard on Rabbit and Human Erythrocytes. Blood 1975;45(6):779-88.Applicant
• Springer, J.B. et al Isophosphoramide Mustard and Its Mechanism of Bisalkylation J. Org. Chem 1998 Oct. 16; 63(21):7218-7222.Applicant
• Valu, K.K. et al., DNA-directed Alkylating Agents. 3. Structure-activity relationships for Acridine-linked Aniline Mustards: Consequences of Varying the Length of the Linker Chain. J. Med. Chem 1990 Nov: 33(11):3014-9.Applicant
• Verschaeve, L. et a. “Mutagenicity of Ethyleneimine” Mutation Res. 238:39-55 (1990).Applicant
• Vlasov, V.V. et al., -The Feasibility, Of Blocking Influenza Infections by Means of Alkylating Derivatives of Oligonucleotides, Molecular Genetics, Microbiology, and Virology, 1984, No. 11.Applicant
• Warrington, Derivatives of Aziridine as Inactivants for Foot-and-Mouth Disease Virus Vaccines Am J. Vet. Res., vol. 34, No. 8. pp. 1087-1091.Applicant
• Wickham, G. et al., DNA-binding Properties and Antitumour Activity of Monofunctional Alkylating Groups Attached to the DNA-intercalating Chromophore Phenanthridine: n-Brotnoalkylplienanthridinium Bromides, Biochimic ct Biophysica Aeta 1991 1073:528-37.Applicant
• Wilke, W.S. et cal., Parenteral Nitrogen Mustard for Inflammatory Arthritis, C'lev. Clin. J. Med. 1990 Oct.; 57(7):643-46.Applicant
• Yamamoto, et al. Cancer Research 26, pt. 1, 2301-2306 (Nov. 1966).Applicant
• Yang, C. et al The Preparation of an Inactivated Antigen for Bluetongue Serology Zentralbl Veterinarmed [B] 1984 Mat; 31(4);290-6.Applicant