US 9,897,538 B2Grant
Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
Issue Date:2018-02-20
•18 Claims
•33 Drawing Sheets
Abstract
Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.
Metadata
Assignee
- The General Hospital Corporation
Inventors
- Guillermo J. Tearney
- Brett Eugene Bouma
Application Information
Application Number:US 10/136,813
Filing Date:2002-04-30
Priority Date:2001-04-30
Art Unit:3737
Classifications
IPC:
A61B5/00G01N21/47G01B9/02
Patent Drawings (33 sheets)
Description
Cross-Reference to Related Application
[0001] The present application claims priority from provisional application No. 60/287,477, filed Apr. 30, 2001, and commonly assigned to the assignee of the present application, and which is incorporated herein in its entirety.
Field of the Invention
[0002] The present invention relates to methods for optical imaging using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The present also relates to an imaging probe apparatus for implementing the method.
Background
[0003] Optical coherence tomography is an imaging technique that measures the interference between a reference beam of light and a detected beam of light that has impinged on a target tissue area and been reflected by scatterers within tissue back to a detector. In OCT imaging of blood vessels an imaging probe is inserted into a blood vessel and a 360 degree circular scan is taken of the vessel wall in series of segments of a predetermined arc to produce a single cross sectional image. The probe tip is rotated axially to create a circular scan of a tissue section and also longitudinally to scan a blood vessel segment length, thus providing two-dimensional mapped information of tissue structure. The axial position of the probe within the lumen remains constant with respect to the axial center of the lumen. However, the surface of the wall may vary in topography or geometry, resulting in the variance of the distance between the probe tip and the surface. Since conventional OCT imaging uses a fixed waveform to create the incident light beam in a schematically rectangular “window” of a certain height, the variation in surface height of the wall may result in the failure to gather tissue data in certain regions of the blood vessel wall. It would desirable to have a feedback mechanism that would cause the modification of the waveform to shift the window based on where the probe is and what it sees.
[0004] In traditional OCT systems, the length of the scanning line and its initial position have always been constant and fixed. One way to overcome this problem is to make the window larger. The problem with this is that the signal to noise ratio and accompanying sensitivity decrease because one is collecting information over a larger area in the same amount of time.
[0005] It would be desirable to use the identification of the tissue surface to adjust the starting position of the scan to a different spot. The identification of the surface could also be used to adjust the focal location in the sample arm. It would additionally be desirable if the identification of the attenuation of light within the tissue were used to adjust the scan range. The attenuation identification could also be used to determine an optimal depth of focus or confocal parameter.
Summary of the Invention
[0006] The present invention provides methods for optical imaging using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The present also relates to an imaging probe apparatus for implementing the method. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan.
[0007] The present invention provides a time delay scanning unit as described herein. The present invention also provides a focus adjusting mechanism for an optical scanning system. The present invention also provides a method of time delay scanning to more accurately determine probe to tissue surface distance variations due to surface topography and probe length/design.
[0008] The present invention provides a rocking mirror, as one of several novel mechanisms, to create the delay line. A rocking mirror can be moved much faster and more accurately to retain synchronicity with the computer and the scanning probe. The present invention provides an algorithm to determine position to determine the changes to the galvanometric DC offset angle to conform to tissue distance from the probe tip. In addition, the present invention provides dynamic active feedback to alter the galvanometric AC angle to adjust the coherence gate scan depth to contain only useful image information. Finally, the present invention also is capable of using dynamic active feedback to adjust the focusing properties of the catheter (focal length, spot size, and confocal parameter).
[0009] These and other objects, features, and advantages of the present invention are discussed or apparent in the following detailed description of the invention, in conjunction with the accompanying drawings and the appended claims.
Brief Description of the Drawings
[0010] The various features and advantages of the invention will be apparent from the attached drawings, in which like reference characters designate the same or similar parts throughout the figures, and in which:
[0011] FIG. 1 is a graph of a seradyne waveform of a conventional DC baseline offset.
[0012] FIG. 2A is a graph of the vessel wall offset contour of one contour scan waveform.
[0013] FIG. 2B is the normal (constant offset) scanning wave of ΔLR.
[0014] FIG. 2C a graph of the superimposition of the contour ΔL of FIG. 2A onto the seradyne waveform of FIG. 2B .
[0015] FIG. 2D is the compensated reference arm scan over a period of two axial scans e1 and e2.
[0016] FIG. 3A is a graph of the scan depth control.
[0017] FIG. 3B is a cross-sectional representation of the lumen and the scan range of FIG. 3A .
[0018] FIG. 3C is an image of the cross section of an actual scan.
[0019] FIG. 4 is a comparison of the traditional OCT image window and a window using the present invention.
[0020] FIG. 5 is a graph of the initial offset and Δz the useful scan range.
[0021] FIG. 6 is a graph of the modified galvanometric waveform mapped to conform the reference arm delay to the tissue surface contour.
[0022] FIGS. 7A-C show successive delay scan lines of the reference arm.
[0023] FIG. 8A shows the Δx versus ΔL.
[0024] FIG. 8B shows time versus LR.
[0025] FIG. 9 shows a flow diagram of the algorithm according to one embodiment of the present invention.
[0026] FIG. 10 shows four possible hits of signal threshold strength and potential tissue surface boundary.
[0027] FIG. 11 shows a scan line.
[0028] FIG. 12 shows the array of the output/storage of the galvanometric waveform to computer memory.
[0029] FIG. 13A shows the old and FIG. 13B new window attainable from block 28 of FIG. 9 .
[0030] FIG. 14 shows a flow diagram for an alternative embodiment of the present invention providing an autofocus algorithm.
[0031] FIG. 15 shows an algorithm for confocal parameter adjustment during confocal microscopy analysis.
[0032] FIG. 16 shows a schematic of an apparatus according to one embodiment of the present invention.
[0033] FIG. 17 shows a schematic of the delay line.
[0034] FIG. 18 is a schematic diagram of an alternative system in which the delay line is created by a mirror 84 is reciprocatingly mounted on a linear translator 85.
[0035] FIG. 19 is a schematic diagram showing a further alternative system in which a drum 65 controlled by a computer 25.
[0036] FIG. 20 illustrates an alternative using an acousto-optic modulator.
[0037] FIG. 21 shows a catheter according to the present invention.
[0038] FIG. 22 shows a detail of a catheter according to one embodiment of the present invention.
[0039] FIG. 22A shows an inset of FIG. 22 illustrating the movement of the lens with respect to the fiber tip.
[0040] FIG. 23 is a detail of a catheter design incorporating a balloon or an expansion chamber to control lens-fiber distance offset.
[0041] FIG. 24 shows a schematic view of a system for changing focus.
[0042] FIG. 25 shows a schematic view of an alternative embodiment system where the fiber-lens separation is fixed and the separation between the lens and the reflector/prism is changed.
[0043] FIG. 26 shows a schematic view of a system where the gap between the fiber and a compound lens composed of multiple elements.
Detailed Description of the Embodiments
[0044] Offset and Scan Depth Control
[0045] FIG. 1 is a graph of a seradyne waveform of a conventional DC baseline offset, where LR is the reference arm optical delay distance offset and t is time (e.g., 0-20 kHz). One scan image length is shown as “e1” and a second is shown as “e2”. The peak-to-peak amplitude is called the AC component.
[0046] FIG. 2A shows a graph of the vessel wall offset contour of one contour scan waveform where the x-axis is time and the y-axis is ΔL. FIG. 2B shows the normal (constant offset) scanning wave of ΔLR which is a seradyne wave and is shown in where each period is a single scan image (shown as bracketed Axial Scan 1 having a scan image length of e1 and Axial Scan 2 having a scan image length of e2). In a given contour there can be somewhere in the range of 250-500 seradyne scans. FIG. 2A shows the offset correction for a period of a single scan. Optical delay (ΔL) is calculated as
ΔL=ΔLS−ΔLR
where ΔLS is the distance of the sample arm to the tissue surface and ΔLR is the optical path of the reference arm.
ΔL=ΔLS−ΔLR
where ΔLS is the distance of the sample arm to the tissue surface and ΔLR is the optical path of the reference arm.
[0047] FIG. 2C shows the superimposition of the contour ΔL of FIG. 2A onto the seradyne waveform of FIG. 2B . “A” is the start gate; “B” is the tissue or vessel surface; “C” is the inside tissue; “D” is the end gate; and “e” is the waveform period. FIG. 2D shows the compensated reference arm scan over a period of two axial scans e1 and e2. A small image window is desirable to reduce signal to noise level. The scan is started at offset “a” (start gate) which is slightly away from the vessel surface so that the vessel surface is at the top of the scan. This is useful in establishing the initial scan offset (starting measurement) for determination of the algorithm (as discussed in detail below). The difference between “b” and “a”, expressed as b-a, is the deadspace between the outside and the vessel surface. b-c is the area inside the vessel surface. The image window of FIG. 2C can be expressed as d-a.
[0048] FIG. 3A is a graph of the scan depth control. FIG. 3B is a cross-sectional representation of the lumen and the scan range of FIG. 3A . The innermost circle is the catheter 1, the next circle outward is the vessel lumen 2, the next circle outward is the blood vessel wall 3, and the maximum scan range is indicated at 4. The “+” in a circle area is the useful scan range; the − (minus sign) in a circle is beyond the useful scan range. FIG. 3C is an image of the cross section of an actual scan.
[0049] FIG. 4 shows a comparison of the traditional OCT image window, shown as a square labeled 5 (in solid line) and a window obtainable using the algorithm of the present invention where the image window labeled as 6 (in dashed line). The smaller window 6 has much higher signal to noise ratio and therefore provides significantly increased sensitivity, resulting in an improved image quality.
[0050] With previous OCT, the scan waveform has a constant AC component and a fixed DC, or slowly varying component. With the present invention the AC component of the waveform as well as the DC component vary with the feedback from the algorithm. See FIG. 5 : “D”, the initial offset and Δz the useful scan range is observed to determine how to modify the waveform for the next scan. FIG. 6 is a graph of the modified galvanometric waveform mapped to conform the reference arm delay to the tissue surface contour.
[0051] FIGS. 7A-C show successive delay scan lines of the reference arm. FIGS. 7A1 and 7A2 shows amplitude a1, and Δz1. FIGS. 7B1 and 7B2 show amplitude a2=2×a1 and Δz2=2×Δz1. FIGS. 7C1 and 7C2 show amplitude a3=0.5×a1 and Δz3=0.5×Δz1. The longer the range (Δz), the greater the delay in the reference arm.
[0052] FIG. 8A shows Δx versus ΔL. FIG. 8B shows time versus LR. As the determined scan range increases, the galvanometric reference arm AC component also increases. The DC offset follows the curve representing the tissue surface contour, as in FIG. 8B . Note that Scan 1, Scan 2, etc., of FIG. 8A maps onto Scan 1 and Scan 2 of FIG. 8B . Successive scans 3, 4, . . . N are adjusted for tissue surface offset and optimal scan range in a similar manner. Examination of the data in the present scan line (axial scan) or scan lines determines the offset to the tissue surface and the optimal coherence gate for the following N scan lines. In this manner, real-time dynamic feedback is provided and enables imaging of irregular tissue contours with an optimal sensitivity.
[0053] Method
[0054] FIG. 9 shows a flow diagram of the algorithm according to one embodiment of the present invention. A first scan line is taken at block 10 sufficient to find the tissue surface “S” at block 12 at a relatively large scan range (block 14) (for example, about 3-10 mm, although other ranges can be used as appropriate). To find the surface one of at least three methods can be used. The first method is to use the adaptive threshold (“T”). The second method uses the first derivative dI(z)/dz=D1. The third method uses the second derivate zero crossing: d2I(z)/dz2=D2.
[0055] There are several rules A, B, and C involved. For the first method rule “A” is: if I(z1)>T, then S=z1. For the second method, rule “B” is: if dI(z2)/dz>T, then=z2S. For the third method, rule “C” is: if d2I(z3)/dz2=0, then=z3S. Note, I(z) may need to be filtered to remove noise before doing the derivatives and reduce the introduction of preprocessing spikes. Such filtration may be achieved using any of a number of filters known to those skilled in the art, including, but not limited to, linear blur, Gaussian, windows, low pass filters, convolution, morphology, and the like. If the surface is not found, repeat block 10, but change the range offset based on the results at block 12. For example, if there is no signal, the offset and range may be altered in a random manner. If there is a signal but it is weak and did not exceed an adaptive threshold, the offset is adjusted (i.e., move the S and gate toward the signal and try again). That offset is made based on the intensity of reflect light detected by the detector.
[0056] There could be a potential problem at block 12 if the sheath plus internal reflections is catheter based, or signal based, where the highest signal is inside the tissue. In such a case there may be more than one location “z” which has the derivatives>T.
[0057] In such cases the rules A, B, and C above are parsed to determine which corresponds to tissue surfaces. FIG. 10 shows four possible hits. There is only one that corresponds to the tissue surface. ε is a small increment. Peak “A” shows an isolated hit where there is no appreciable signal on either side of the peak; therefore, for zA−ε<zA<zA+ε, there is I(zA±ε)<<I(z). Peak “B” shows a peak where there is no signal before (i.e., to the left) but there is signal after (i.e., to the right); therefore, for zB−ε<zB there is I(zB−ε)<<I(zB) and I(zB)≈I(zB+ε). Stated differently, FIG. 10 shows four cases where the signal (image data) threshold is exceeded. Peak “A” has no signal before or after it (i.e., within the next pixel, increment or ε) it (sometimes referred to as above (z0) or below (zmax)); therefore, it is discounted. Peak “D” is discounted for the same reason/rule: it has no signal before or after it. For peak “C” there is signal before it and after it, therefore it cannot be at the surface. For peak “B” there is signal after it, but not before it. Therefore, peak “B” indicates the start of the tissue surface boundary.
[0058] Referring back to block 14 there is now a fixed range, typically larger than desired for the first line. FIG. 11 shows a scan line. The optimal scan range R is what is to be determined. First, the curve is smoothed (see methods mentioned above). Then, second, go out to a large z where there clearly is no signal; i.e., find where I(zmax)=noise. This can be verified by finding where the standard deviation of (I(z±ε)) is low. Third, decrease z (i.e., move z towards S) until I(z) starts to increase again; i.e., I(z′)>I(zmax) and where R=z′−S.
[0059] Another method of achieving a similar result is to first smooth and take the derivative of the curve and find out where d(I(z′))/dz=0 and therefore R=z′−S.
[0060] Other statistical methods are possible. A basic operating parameter is that one wants minimal signal outside of and as much signal as possible inside of the scan range R. This can be achieved by zeroth order, first derivative, second derivative, probability distribution functions statistics (e.g., standard deviation), fitting to exponential and other standard data analysis procedures known in the art.
[0061] Spikes in noise, but which are artifacts which could be counted in a signal solution can be a potential problem. One can use filters (median, ordered, adaptive, closing, dilitation or other filter known in the art) to eliminate spikes caused by out of range artifacts.
[0062] Referring back to FIG. 9 , the reference arm delay waveform is modified at block 16. There is a known 1:1 relationship between data acquired by the computer and reference arm position. S and R can be used to modify the waveform controlling the optical delay line. S and R now need to be inserted into an equation which controls the galvanometric waveform. Thus G(t)=f(S,R,t), where G(t) is the galvanometric waveform and f is a function. This G(t) is sent digitally or analog to the galvanometric waveform. FIG. 12 shows the array of the output/storage of the galvanometric waveform to computer memory block 20 and which goes to remapping at block 28, where “N” is the number of axial scans per image. This S,R array indicates how to remap the data into real space again for block 28 (of FIG. 9 ).
[0063] FIG. 13A shows the old and FIG. 14B shows the new window attainable from block 28 (refer back to FIG. 9 and accompanying description of reference letters). I(x,z) are inserted into a remapping function with the inputs being an array of S, R to create the remapped image of block 28. For every line, x, there are different elements, S and R, in the array (i.e., S0 corresponds to I(x0,z) and z is continuous. This relates to the distance between the probe and the chosen range.
[0064] Remapping (block 28 of FIG. 9 ) is preferably done after each scan. For storage, the image is remapped after acquisition. For display, remapping is done interactively. Add each S that is known for each of the scan lines (the vertical bars) to the data and the contour is remapped. S is added to the offset of the image. In other words, shifting the data for any given exposition by S. Each vertical bar gets (axial scan) remapped (shifted) based on their respective S value. For example, is the z values in x1 are offset by S1.
[0065] There are multiple different equations possible for remapping, examples of which are shown below:
I(xn,z)=Iacq(xn,z−Sn) (1)
I(xn,z)=Iacq(xn,z−Sn−1) (2)
I(xn,z)=Iacq(xn,z−Sn+1) (3)
where n identifies a specific axial scan and where n is close to where mapping is occurring.
I(xn,z)=Iacq(xn,z−Sn) (1)
I(xn,z)=Iacq(xn,z−Sn−1) (2)
I(xn,z)=Iacq(xn,z−Sn+1) (3)
where n identifies a specific axial scan and where n is close to where mapping is occurring.
[0066] One is thus using array R,S to redisplay/remap the image. This is the most efficient way of storing the remapped image. S can be stored+Iacq(z) and reconstructed offline. Or, S+Iacq(z) can be reconstructed dynamically or interactively.
[0067] The output is sent to the reference arm at block 18 and also saved in the computer at block 20. If the image is not done at block 22, the next scan line is taken at block 24 by cycling back repeatedly to block 12 until the image is acquired. If the image is done, then the image is remapped at block 28 using the surface S information and the modified reference arm delay waveform stored and recalled from the computer memory from block 20. The image is then saved or displayed at block 30. If no other image at block 32 is to be taken, the process is done at block 40.
[0068] Optionally, if another image is to be taken at block 32, then the algorithm queries at block 34 whether a new location is taken. If yes, then at line 36 the first scan line is taken back at block 10. If no image is scanned at line 38, then the next surface location S is found at block 12.
[0069] Autofocus
[0070] In an alternative embodiment the present invention can be used in an autofocus mode. FIG. 14 shows a flow diagram for an autofocus algorithm.
[0071] If Sn and Rn are known, then an optimal focal length is also known and the optimal spot size and confocal parameters can be calculated. If some function “g” is applied to the catheter which causes a change in focus by zf, and which occurs at pixel “n” where one knows Sn, then all one needs to know is, if one is at Sk then one can calculate how g changes as (Sk-Sn). Therefore, for a given n, one knows what one has to do to the catheter to obtain a focus of zf(n). Sn is also known. So, Sn+1 creates g(n+1) for all n. In other words, S allows one to adjust the focus so that it is optimally present within or at the surface of the tissue. R allows one to adjust the confocal parameter so that the spot size is minimized over the optimal scan range. These alterations of the catheter are performed in real-time, using dynamic feedback obtained from the image. These enhancements enable optimal imaging of the tissue under investigation.
[0072] A key feature of the present invention is that one can calculate where to move the focus if one position is known. One does not have to iteratively modify the focus until it is optimized each time, only once, and, once S is calculated, modify focus thereafter using the previous or present S of the scan. The present invention allows imaging of tissue with an irregular surface and keeping substantially the entire image in view. Moreover, the scan range is decreased so as to only include useful image information, therefore decreasing the bandwidth of the signal and increasing the image sensitivity of even possibly up to some 3-5 times. The sensitivity increase may be implemented by decreasing the bandwidth of the filter used reject noise while performing heterodyne or lock-in detection. This filter bandwidth may be adjusted dynamically by using diode switched capacitor arrays. Increasing sensitivity is equivalent to increasing speed while keeping accuracy. This is important in cardiovascular system imaging. Further, increasing speed decreases motion artifacts from heartbeat and blood pressure with concomitant lumen expansion and accompanying modulation of the arm-sample distance. Autofocus enables one to place the optimal focus on the tissue for every scan position in a rapid manner, thus leading to sharper images. The present invention also has the advantage of compensating for probe length variation.
[0073] The present invention provides a time delay scanning unit as described herein. The present invention also provides a focus adjusting mechanism for an optical scanning system. The present invention also provides a method of time delay scanning to more accurately determine probe to tissue surface distance variations due to surface topography and probe length/design.
[0074] Confocal Parameter
[0075] FIG. 15 shows an algorithm for confocal parameter adjustment during confocal microscopy analysis. The confocal parameter is optimized to R, the optimal scan gate range. After the first scan line is taken at block 210, the optimal grating range R (as previously described hereinabove) is determined, block 212. The optimal confocal parameter 2zR is calculated at block 214. Then the catheter confocal parameter is modified at block 216 for some 2ze>(R+ε). If the image is not done at block 218, go to the next scan line 220. If the scan is done, end at block 222. 2zR=(2πω02)/λ, where ω0 is the beam radius; λ is wavelength, and 2zR is the confocal parameter.
[0076] Apparatus
[0077] FIG. 16 shows a schematic of an apparatus according to one embodiment of the present invention. The basic description of this and the subsequent drawings is found in Ozawa et al., U.S. Pat. No. 6,069,698, which is incorporated herein. The basic description of the relevant parts of FIG. 16 corresponds to FIG. 1 of Ozawa et al.
[0078] FIG. 17 shows a schematic of the delay line. The galvanometer is a motor that attaches to the mirror and actuates partial tilt/rotation of the mirror. Only one delay is necessary, although more than one delay line is possible. Alternatively, one can use a diffraction grating having a period which changes as a function of time to make the mirror fixed and not rotating. Simple, blazed, or other grating known to those of ordinary skill in the art, can be used. The grating sends different wavelengths to a lens and a galvanometric scanning mirror which alters the optical delay in the reference arm as a function of mirror angle.
[0079] FIG. 18 is a schematic diagram of an alternative system in which the delay line is created by a mirror 84 is reciprocatingly mounted on a linear translator 85 which is controlled by a motor/driving unit 86 and 87. A description of basic components FIG. 18 is found in the specification corresponding to FIG. 11 of Ozawa et al. The mirror 84 oscillates at a certain rate. According to the present invention, the algorithms would have the mirror 84 scan back and forth and gradually shifts its translation over time to track the surface of the tissue. Each time the mirror 84 scans, it is called one scan or one axis of probing.
[0080] FIG. 19 (similar to FIG. 6 of Ozawa et al.) is a schematic diagram showing a further alternative system in which a drum 65 controlled by a computer 25. Small changes to the diameter of the drum, induced by piezoelectrics, stretch the thin fibers wound around the drum. The increased fiber length contributes a delay line.
[0081] FIG. 20 illustrates an alternative using an acousto-optic modulator 153 is a computer controlled diffraction grating where the periodicity of the grating can be changed based on the frequency to the acousto-optic modulator.
[0082] FIG. 21 shows a catheter according to the present invention, and is a modification of FIG. 4 of Ozawa et al.
[0083] FIG. 22 shows a detail of a catheter according to one embodiment of the present invention. The design is based on FIG. 4 of Ozawa et al. FIG. 22A (a detail of FIG. 21 ) shows the distal end of the catheter having an optical fiber fixed into block 49, which fixes the fiber to the spring. Instead of a fixed block 49 the present invention uses a block which can have its length altered. In one embodiment, the block is a piezoelectric transducer (“piezo”) 49A connected by a wire 49B. The voltage changes the length of the piezo 49A and therefore changes the separation (the gap) between the lens 56 and the tip of the optical fiber. Movement of the lens with respect to the fiber tip is shown in the inset FIG. 22A . 58 is the output beam. 58a is the output beam at piezo voltage Va and 58b is the output beam at piezo voltage Vb.
[0084] There are alternative ways to controllably change the distance between the lens and the fiber tip. One way is by using a balloon or an expansion chamber instead of the piezo 49. Instead of the wire 49B there is an air or hydraulic capillary 49C extending in the catheter 8. See FIG. 23 , where 58a is the output beam at air or fluid pressure Pa and 58b is the output beam at pressure Pb.
[0085] FIGS. 24 and 25 are two general ways to translate a focus. FIG. 24 shows a schematic view of a system which illustrates that as the distance between the fiber and the lens changes, the location of the focus changes. For object distance d1 the focus is shown as a solid ray tracing line. For distance d2 the focus is shown as the dashed ray tracing line. The relationship between distance and focal length is 1/d+1/i=1/f, where “i” is the image distance. Magnification M=i/d.
[0086] FIG. 25 shows a schematic view of a system where the fiber-lens separation is fixed and the separation between the lens and the reflector/prism is changed. In this embodiment, the light beam at distance d1 has a different focal point than the light beam at distance d2. The translation can be achieved by any of the mechanisms described above.
[0087] FIG. 26 shows a schematic view of a system where the gap between the fiber and a compound lens composed of multiple elements is fixed and, e.g., the gap between the lens and the reflector is fixed, but the relative separation of the gap between individual lens elements changes. An alternative embodiment utilizes a lens having a flexible cover and filled with an optically transparent fluid (e.g., saline, oil), gas or other substance. As the fluid composition, flexible cover shape or the like is changed, the focal length also changes.
[0088] It will be understood that the terms “a” and “an” as used herein are not intended to mean only “one,” but may also mean a number greater than “one.” While the invention has been described in connection with certain embodiments, it is not intended to limit the scope of the invention to the particular forms set forth, but, on the contrary, it is intended to cover such alternatives, modifications, and equivalents as may be included within the true spirit and scope of the invention as defined by the appended claims. All patent, applications and publications referred to herein are incorporated by reference in their entirety.
Claims
The invention claimed is:
1. An apparatus for obtaining information associated with at least one structure, comprising:
at least one optical coupler first arrangement configured to receive at least one first optical radiation from the at least one structure and at least one second optical radiation from a reference; and
at least one computer second arrangement configured to determine the information regarding the at least one structure, wherein the at least one second arrangement is further configured to (i) determine a distance from at least one portion of the at least one structure to the at least one first arrangement based on the information, and (ii) track at least one peak of at least one signal of the information which includes image data regarding the at least one structure,
wherein the at least one computer second arrangement is further configured to, as a function of the distance and the at least one peak, control an optical radiation path length of a third optical radiation which is at least one of:
i. at least one of transmitted to or received from the at least one structure, or
ii. at least one of transmitted to or received from the reference, and
wherein the at least one computer second arrangement is further configured to determine the distance using at least one of a zero-th order procedure, a first derivative procedure, a second derivative procedure, a determination of a probability distribution function statistics or a fitting procedure as applied to the information which is based on the distance and the at least one peak.
2. The apparatus according to claim 1, wherein the at least one portion is a surface of the at least one structure.
3. The apparatus according to claim 1, wherein the at least one structure includes an anatomical structure.
4. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to (i) obtain information associated with the at least one structure associated the controlled optical radiation path length, and (ii) generate at least one image of the at least one portion as a function of the information.
5. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to control an optical radiation path length while an image of the at least one portion is generated.
6. The apparatus for obtaining information associated with at least one structure, comprising:
at least one optical coupler first arrangement configured to receive at least one first optical radiation from the at least one structure and at least one second optical radiation from a reference; and
at least one computer second arrangement configured to determine the information regarding the at least one structure as a function of depth thereof, wherein the at least one second arrangement is further configured to determine a distance from at least one portion of the at least one structure to the at least one first arrangement based on the information,
wherein the at least one computer second arrangement is further configured to, as a function of the distance, control an optical radiation path length of a third optical radiation which is at least one of:
i. at least one of transmitted to or received from the at least one structure, or
ii. at least one of transmitted to or received from the reference,
wherein the at least one computer second arrangement is further configured to determine the distance using at least one of a zero-th order procedure, a first derivative procedure, a second derivative procedure, a determination of a probability distribution function statistics or a fitting procedure as applied to the information which is based on the depth,
wherein the at least one second arrangement is further configured to determine a length from the at least one portion based on the at least one first optical radiation, and
wherein the at least one second arrangement is further configured to, as a function of the length, control a focal distance of the at least one third optical radiation which is at least one of transmitted to or received from the at least one structure.
7. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to determine an optical radiation penetration depth within the at least one portion based on at least one of the first optical radiation or the second optical radiation, wherein the at least one second arrangement is further configured to, as a function of the penetration depth, control the optical radiation path length range.
8. An apparatus for obtaining information associated with at least one structure, comprising:
at least one lens first arrangement configured to receive at least one first optical radiation from the at least one structure; and
at least one computer second arrangement configured to determine a length from at least one portion of the at least one structure based on the at least one first optical radiation, wherein the at least one computer second arrangement is further configured to, as a function of the length, control a focal distance of at least one of at least one second optical radiation which is at least one of transmitted to or received from the at least one structure.
9. The apparatus according to claim 8, wherein the at least one portion is a surface of the at least one structure.
10. The apparatus according to claim 8, wherein the at least one second arrangement is further configured to determine a distance from the at least one portion based on at least one of the at least one first optical radiation or at least one third electromagnetic radiation received from a reference, wherein the at least one second arrangement is further configured to, as a function of the distance, control an optical radiation path length of the at least one second optical radiation which is at least one:
i. at least one of transmitted to or received from the at least one structure, or
ii. at least one of transmitted to or received from the reference.
11. The apparatus according to claim 10, wherein the at least one second arrangement is further configured to determine the distance using at least one of a zero-th order procedure, a first derivative procedure, a second derivative procedure, a determination of a probability distribution function statistics or a fitting procedure.
12. The apparatus according to claim 8, wherein the at least one structure includes an anatomical structure.
13. The apparatus according to claim 10, wherein the at least one second arrangement is further configured to (i) obtain information associated with the at least one structure associated the controlled optical radiation path length, and (ii) generate at least one image of the at least one portion as a function of the information.
14. The apparatus according to claim 8, wherein the at least one second arrangement is further configured to control an optical radiation path length while an image of the at least one portion is generated.
15. The apparatus according to claim 8, wherein the at least one first arrangement is further configured to receive at least one third optical radiation from a reference, and wherein at least one second arrangement is configured to determine the distance from the at least one portion based on at least one of the first optical radiation or the third electromagnetic radiation.
16. The apparatus according to claim 10, wherein the at least one second arrangement is further configured to determine an optical radiation penetration depth within the at least one portion based on at least one of the first electromagnetic radiation or the third optical radiation, wherein the at least one second arrangement is further configured to, as a function of the penetration depth, control the optical radiation path length range.
17. A method for obtaining information associated with at least one structure, comprising:
receiving at least one first optical radiation from the at least one structure and at least one second optical radiation from a reference;
determining the information regarding the at least one structure as a function of depth thereof;
determining a distance from at least one portion of the at least one structure based on the information;
tracking at least one peak of at least one signal of the information which includes image data regarding the at least one structure;
as a function of the distance and the at least one peak, controlling an optical radiation path length of at least one third optical radiation which is at least one of:
i. at least one of transmitted to or received from the at least one structure, or
ii. at least one of transmitted to or received from the reference; and
using a computer arrangement, determining the distance using at least one of a zero-th order procedure, a first derivative procedure, a second derivative procedure, a determination of a probability distribution function statistics or a fitting procedure as applied to the information which is based on the distance and the at least one peak.
18. A method for obtaining information associated with at least one structure, comprising:
receiving at least one first optical radiation from the at least one structure;
determining a length from at least one portion of the at least one structure based on the at least one first optical radiation; and
using a computer arrangement, as a function of the length, controlling a focal distance of at least one of at least one second optical radiation which is at least one of transmitted to or received from the at least one structure.
Patent Citations (244)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US2339754(A) | 1944-01-01 | Brace | Applicant |
| US3601480(A) | 1971-08-01 | Randall | Applicant |
| US3856000(A) | 1974-12-01 | Chikama | Applicant |
| US3941121(A) | 1976-03-01 | Olinger | Applicant |
| US4030827(A) | 1977-06-01 | Delhaye et al. | Applicant |
| US4141362(A) | 1979-02-01 | Wurster | Applicant |
| US4295738(A) | 1981-10-01 | Meltz et al. | Applicant |
| US4300816(A) | 1981-11-01 | Snitzer et al. | Applicant |
| US4479499(A) | 1984-10-01 | Alfano | Applicant |
| US4585349(A) | 1986-04-01 | Gross et al. | Applicant |
| US4601036(A) | 1986-07-01 | Faxvog et al. | Applicant |
| US4607622(A) | 1986-08-01 | Fritch et al. | Applicant |
| US4631498(A) | 1986-12-01 | Cutler | Applicant |
| US4639129(A) | 1987-01-01 | Hullein et al. | Examiner |
| US4770492(A) | 1988-09-01 | Levin et al. | Applicant |
| US4868834(A) | 1989-09-01 | Fox et al. | Applicant |
| US4925302(A) | 1990-05-01 | Cutler | Applicant |
| US4928005(A) | 1990-05-01 | Lefevre et al. | Applicant |
| US4965441(A) | 1990-10-01 | Picard | Applicant |
| US4993834(A) | 1991-02-01 | Carlhoff et al. | Applicant |
| US5039193(A) | 1991-08-01 | Snow et al. | Applicant |
| US5040889(A) | 1991-08-01 | Keane | Applicant |
| US5045936(A) | 1991-09-01 | Lobb et al. | Applicant |
| US5065331(A) | 1991-11-01 | Vachon et al. | Applicant |
| US5120953(A) | 1992-06-01 | Harris | Applicant |
| US5127730(A) | 1992-07-01 | Brelje et al. | Applicant |
| US5197470(A) | 1993-03-01 | Helfer et al. | Applicant |
| US5202745(A) | 1993-04-01 | Sorin et al. | Applicant |
| US5248876(A) | 1993-09-01 | Kerstens et al. | Applicant |
| US5262644(A) | 1993-11-01 | Maguire | Applicant |
| US5291885(A) | 1994-03-01 | Taniji et al. | Applicant |
| US5293872(A) | 1994-03-01 | Alfano et al. | Applicant |
| US5293873(A) | 1994-03-01 | Fang | Applicant |
| US5304810(A) | 1994-04-01 | Amos | Applicant |
| US5305759(A) | 1994-04-01 | Kaneko et al. | Applicant |
| US5317389(A) | 1994-05-01 | Hochberg et al. | Applicant |
| US5353790(A) | 1994-10-01 | Jacques et al. | Applicant |
| US5383467(A) | 1995-01-01 | Auer et al. | Applicant |
| US5411016(A) | 1995-05-01 | Kume et al. | Applicant |
| US5419323(A) | 1995-05-01 | Kittrell et al. | Applicant |
| US5439000(A) | 1995-08-01 | Gunderson et al. | Applicant |
| US5441053(A) | 1995-08-01 | Lodder et al. | Applicant |
| US5450203(A) | 1995-09-01 | Penkethman | Applicant |
| US5454807(A) | 1995-10-01 | Lennox et al. | Applicant |
| US5459325(A) | 1995-10-01 | Hueton et al. | Applicant |
| US5465147(A) | 1995-11-01 | Swanson | Applicant |
| US5486701(A) | 1996-01-01 | Norton et al. | Applicant |
| US5491524(A) | 1996-02-01 | Hellmuth et al. | Applicant |
| US5491552(A) | 1996-02-01 | Knuttel | Applicant |
| US5526338(A) | 1996-06-01 | Hasman et al. | Applicant |
| US5562100(A) | 1996-10-01 | Kittrell et al. | Applicant |
| US5565986(A) | 1996-10-01 | Knüttel | Applicant |
| US5583342(A) | 1996-12-01 | Ichie | Applicant |
| US5590660(A) | 1997-01-01 | MacAulay et al. | Applicant |
| US5600486(A) | 1997-02-01 | Gal et al. | Applicant |
| US5601087(A) | 1997-02-01 | Richards-Kortum et al. | Applicant |
| US5621830(A) | 1997-04-01 | Lucey et al. | Applicant |
| US5623336(A) | 1997-04-01 | Raab et al. | Applicant |
| US5697373(A) | 1997-12-01 | Gunderson et al. | Applicant |
| US5698397(A) | 1997-12-01 | Zarling et al. | Applicant |
| US5710630(A) | 1998-01-01 | Essenpreis et al. | Applicant |
| US5735276(A) | 1998-04-01 | Lemelson | Applicant |
| US5740808(A) | 1998-04-01 | Panescu et al. | Applicant |
| US5748598(A) | 1998-05-01 | Swanson et al. | Applicant |
| US5784352(A) | 1998-07-01 | Swanson et al. | Applicant |
| US5785651(A) | 1998-07-01 | Kuhn et al. | Applicant |
| US5801826(A) | 1998-09-01 | Williams | Applicant |
| US5807261(A) | 1998-09-01 | Benaron et al. | Applicant |
| US5817144(A) | 1998-10-01 | Gregory | Applicant |
| US5842995(A) | 1998-12-01 | Mahadevan-Jansen et al. | Applicant |
| US5843000(A) | 1998-12-01 | Nishioka et al. | Applicant |
| US5843052(A) | 1998-12-01 | Benja-Athon | Applicant |
| US5847827(A) | 1998-12-01 | Fercher | Applicant |
| US5862273(A) | 1999-01-01 | Pelletier | Applicant |
| US5865754(A) | 1999-02-01 | Sevick-Muraca et al. | Applicant |
| US5867268(A) | 1999-02-01 | Gelikonov et al. | Applicant |
| US5871449(A) | 1999-02-01 | Brown | Applicant |
| US5872879(A) | 1999-02-01 | Hamm | Applicant |
| US5877856(A) | 1999-03-01 | Fercher | Applicant |
| US5887009(A) | 1999-03-01 | Mandella et al. | Applicant |
| US5892583(A) | 1999-04-01 | Li | Applicant |
| US5920373(A) | 1999-07-01 | Bille | Applicant |
| US5920390(A) | 1999-07-01 | Farahi et al. | Applicant |
| US5949929(A) | 1999-09-01 | Hamm | Applicant |
| US5951482(A) | 1999-09-01 | Winston et al. | Applicant |
| US5956355(A) | 1999-09-01 | Swanson et al. | Applicant |
| US5968064(A) | 1999-10-01 | Selmon et al. | Applicant |
| US5983125(A) | 1999-11-01 | Alfano et al. | Applicant |
| US5987346(A) | 1999-11-01 | Benaron et al. | Applicant |
| US5991697(A) | 1999-11-01 | Nelson et al. | Applicant |
| US5994690(A) | 1999-11-01 | Kulkarni et al. | Applicant |
| US6004314(A) | 1999-12-01 | Wei et al. | Applicant |
| US6010449(A) | 2000-01-01 | Selmon et al. | Applicant |
| US6014214(A) | 2000-01-01 | Li | Applicant |
| US6033721(A) | 2000-03-01 | Nassuphis | Applicant |
| US6048742(A) | 2000-04-01 | Weyburne et al. | Applicant |
| US6053613(A) | 2000-04-01 | Wei et al. | Applicant |
| US6069698(A) | 2000-05-01 | Ozawa et al. | Applicant |
| US6091496(A) | 2000-07-01 | Hill | Applicant |
| US6091984(A) | 2000-07-01 | Perelman et al. | Applicant |
| US6117128(A) | 2000-09-01 | Gregory | Applicant |
| US6120516(A) | 2000-09-01 | Selmon et al. | Applicant |
| US6134003(A) | 2000-10-01 | Tearney et al. | Applicant |
| US6134010(A) | 2000-10-01 | Zavislan | Applicant |
| US6134033(A) | 2000-10-01 | Bergano et al. | Applicant |
| US6151522(A) | 2000-11-01 | Alfano et al. | Applicant |
| US6160826(A) | 2000-12-01 | Swanson et al. | Applicant |
| US6166373(A) | 2000-12-01 | Mao | Applicant |
| US6174291(B1) | 2001-01-01 | McMahon et al. | Applicant |
| US6185271(B1) | 2001-02-01 | Kinsinger | Applicant |
| US6193676(B1) | 2001-02-01 | Winston et al. | Applicant |
| US6198956(B1) | 2001-03-01 | Dunne | Applicant |
| US6208415(B1) | 2001-03-01 | De Boer et al. | Applicant |
| US6208887(B1) | 2001-03-01 | Clarke | Applicant |
| US6249349(B1) | 2001-06-01 | Lauer | Applicant |
| US6249381(B1) | 2001-06-01 | Suganuma | Examiner |
| US6263234(B1) | 2001-07-01 | Engelhardt et al. | Applicant |
| US6264610(B1) | 2001-07-01 | Zhu | Applicant |
| US6272268(B1) | 2001-08-01 | Miller et al. | Applicant |
| US6272376(B1) | 2001-08-01 | Marcu et al. | Applicant |
| US6274871(B1) | 2001-08-01 | Dukor et al. | Applicant |
| US6282011(B1) | 2001-08-01 | Tearney et al. | Applicant |
| US6308092(B1) | 2001-10-01 | Hoyns | Applicant |
| US6324419(B1) | 2001-11-01 | Guzelsu et al. | Applicant |
| US6341036(B1) | 2002-01-01 | Tearney et al. | Applicant |
| US6353693(B1) | 2002-03-01 | Kano et al. | Applicant |
| US6377349(B1) | 2002-04-01 | Fercher | Applicant |
| US6384915(B1) | 2002-05-01 | Everett et al. | Applicant |
| US6393312(B1) | 2002-05-01 | Hoyns | Applicant |
| US6394964(B1) | 2002-05-01 | Sievert, Jr. et al. | Applicant |
| US6421164(B2) | 2002-07-01 | Tearney et al. | Applicant |
| US6445944(B1) | 2002-09-01 | Ostrovsky | Applicant |
| US6463313(B1) | 2002-10-01 | Winston et al. | Applicant |
| US6469846(B2) | 2002-10-01 | Ebizuka et al. | Applicant |
| US6485413(B1) | 2002-11-01 | Boppart et al. | Applicant |
| US6485482(B1) | 2002-11-01 | Belef | Applicant |
| US6501551(B1) | 2002-12-01 | Tearney et al. | Applicant |
| US6501878(B2) | 2002-12-01 | Hughes et al. | Applicant |
| US6549801(B1) | 2003-04-01 | Chen et al. | Applicant |
| US6552796(B2) | 2003-04-01 | Magnin et al. | Applicant |
| US6556305(B1) | 2003-04-01 | Aziz et al. | Applicant |
| US6556853(B1) | 2003-04-01 | Cabib et al. | Applicant |
| US6558324(B1) | 2003-05-01 | Von Behren et al. | Applicant |
| US6564087(B1) | 2003-05-01 | Pitris et al. | Applicant |
| US6564089(B2) | 2003-05-01 | Izatt et al. | Applicant |
| US6615071(B1) | 2003-09-01 | Casscells, III et al. | Applicant |
| US6622732(B2) | 2003-09-01 | Constantz | Applicant |
| US6680780(B1) | 2004-01-01 | Fee | Applicant |
| US6685885(B2) | 2004-02-01 | Nolte et al. | Applicant |
| US6687007(B1) | 2004-02-01 | Meigs | Applicant |
| US6687010(B1) | 2004-02-01 | Horii et al. | Applicant |
| US6725073(B1) | 2004-04-01 | Motamedi et al. | Applicant |
| US6790175(B1) | 2004-09-01 | Furusawa et al. | Applicant |
| US6806963(B1) | 2004-10-01 | Wälti et al. | Applicant |
| US6816743(B2) | 2004-11-01 | Moreno et al. | Applicant |
| US6980299(B1) | 2005-12-01 | de Boer | Applicant |
| US7006231(B2) | 2006-02-01 | Ostrovsky et al. | Applicant |
| US7231243(B2) | 2007-06-01 | Tearney et al. | Applicant |
| US2001/0020126(A1) | 2001-09-01 | Swanson et al. | Applicant |
| US2001/0047137(A1) | 2001-11-01 | Moreno et al. | Applicant |
| US2002/0016533(A1) | 2002-02-01 | Marchitto et al. | Applicant |
| US2002/0064341(A1) | 2002-05-01 | Fauver et al. | Applicant |
| US2002/0076152(A1) | 2002-06-01 | Hughes et al. | Applicant |
| US2002/0085209(A1) | 2002-07-01 | Mittleman et al. | Applicant |
| US2002/0122246(A1) | 2002-09-01 | Tearney et al. | Applicant |
| US2002/0161357(A1) | 2002-10-01 | Rox et al. | Applicant |
| US2002/0163622(A1) | 2002-11-01 | Magnin et al. | Applicant |
| US2002/0172485(A1) | 2002-11-01 | Keaton et al. | Applicant |
| US2002/0188204(A1) | 2002-12-01 | McNamara et al. | Applicant |
| US2002/0196446(A1) | 2002-12-01 | Roth et al. | Applicant |
| US2002/0198457(A1) | 2002-12-01 | Tearney et al. | Applicant |
| US2003/0023153(A1) | 2003-01-01 | Izatt et al. | Applicant |
| US2003/0026735(A1) | 2003-02-01 | Nolte et al. | Applicant |
| US2003/0135101(A1) | 2003-07-01 | Webler | Applicant |
| US2003/0164952(A1) | 2003-09-01 | Deichmann et al. | Applicant |
| US2003/0171691(A1) | 2003-09-01 | Casscells, III et al. | Applicant |
| US2003/0236443(A1) | 2003-12-01 | Cespedes et al. | Applicant |
| US2004/0086245(A1) | 2004-05-01 | Farroni et al. | Applicant |
| US2004/0100631(A1) | 2004-05-01 | Bashkansky et al. | Applicant |
| US2004/0100681(A1) | 2004-05-01 | Bjarklev et al. | Applicant |
| US2004/0150829(A1) | 2004-08-01 | Koch et al. | Applicant |
| US2004/0166593(A1) | 2004-08-01 | Nolte et al. | Applicant |
| US2005/0018201(A1) | 2005-01-01 | De Boer | Applicant |
| US2005/0128488(A1) | 2005-06-01 | Yelin et al. | Applicant |
| US2005/0197530(A1) | 2005-09-01 | Wallace et al. | Applicant |
| US2006/0039004(A1) | 2006-02-01 | de Boer et al. | Applicant |
| US2007/0002435(A1) | 2007-01-01 | Ye et al. | Applicant |
| US2008/0021275(A1) | 2008-01-01 | Tearney et al. | Applicant |
| US2009/0051923(A1) | 2009-02-01 | Zuluaga | Applicant |
| US2009/0131801(A1) | 2009-05-01 | Suter et al. | Applicant |
| DE4309056 | 1994-09-01 | Applicant | |
| DE19542955 | 1997-05-01 | Applicant | |
| DE10351319 | 2005-06-01 | Applicant | |
| EP110201 | 1984-06-01 | Applicant | |
| EP2511062 | 1988-01-01 | Applicant | |
| EP590268 | 1994-04-01 | Applicant | |
| EP1426799 | 2004-06-01 | Applicant | |
| GB1257778 | 1971-12-01 | Applicant | |
| GB2030313 | 1980-04-01 | Applicant | |
| GB2209221 | 1989-05-01 | Applicant | |
| JP4-056907 | 1992-02-01 | Applicant | |
| JP4135550 | 1992-05-01 | Applicant | |
| JP4135551 | 1992-05-01 | Applicant | |
| JPH04-319345(A) | 1992-11-01 | Applicant | |
| JPH05-130995(A) | 1993-05-01 | Applicant | |
| JPH06-511312 | 1994-12-01 | Applicant | |
| JP10-267631 | 1998-10-01 | Applicant | |
| JPH10-267631 | 1998-10-01 | Applicant | |
| JPH11-056786 | 1999-03-01 | Applicant | |
| JP2000-046729 | 2000-02-01 | Applicant | |
| JP2001-174404 | 2001-06-01 | Applicant | |
| JP2001-212086 | 2001-08-01 | Applicant | |
| JP2001-525580 | 2001-12-01 | Applicant | |
| JP2002-095663 | 2002-04-01 | Applicant | |
| JP2003-504627 | 2003-02-01 | Applicant | |
| JP2003-513278 | 2003-04-01 | Applicant | |
| WO9219930 | 1992-11-01 | Applicant | |
| WO9303672 | 1993-03-01 | Applicant | |
| WO9533971 | 1995-12-01 | Applicant | |
| WO9732182 | 1997-09-01 | Applicant | |
| WO9801074 | 1998-01-01 | Applicant | |
| WO9814132 | 1998-04-01 | Applicant | |
| WO9835203 | 1998-08-01 | Applicant | |
| WO9838907 | 1998-09-01 | Applicant | |
| WO984623 | 1998-10-01 | Applicant | |
| WO9848838 | 1998-11-01 | Applicant | |
| WO9944089 | 1999-09-01 | Applicant | |
| WO9957507 | 1999-11-01 | Applicant | |
| WO99/57507 | 1999-11-01 | Applicant | |
| WO58766 | 2000-10-01 | Applicant | |
| WO138820 | 2001-05-01 | Applicant | |
| WO142735 | 2001-06-01 | Applicant | |
| WO236015 | 2002-05-01 | Applicant | |
| WO238040 | 2002-05-01 | Applicant | |
| WO254027 | 2002-07-01 | Applicant | |
| WO3020119 | 2003-03-01 | Applicant | |
| WO3062802 | 2003-07-01 | Applicant | |
| WO20040066824 | 2004-08-01 | Applicant | |
| WO2004088361 | 2004-10-01 | Applicant | |
| WO4105598 | 2004-12-01 | Applicant | |
| WO20050000115 | 2005-01-01 | Applicant | |
| WO2005054780 | 2005-06-01 | Applicant | |
| WO2006014392 | 2006-02-01 | Applicant | |
| WO2006130797 | 2006-12-01 | Applicant |
Non-Patent Literature (766)
- Nicusor V. Iftimia et al., “A Portable, Low Coherence Interferometry Based Instrument for Fine Needle Aspiration Biopsy Guidance” Accepted to Review of Scientific Instruments, 2005.Applicant
- Abbas, G.L., V.W.S. Chan et al., “Local-Oscillator Excess-Noise Suppression for Homodyne and Heterodyne-Detection”, Optics Letters, vol. 8, pp. 419-421, Aug. 1983 issue.Applicant
- Agrawal, G.P., “Population Pulsations and Nondegenerate 4-Wave Mixing in Semiconductor-Lasers and Amplifiers”, Journal of the Optical Society of America B—Optical Physics, vol. 5, pp. 147-159, Jan. 1998.Applicant
- Andretzky, P. et al., “Optical Coherence Tomography by Spectral Radar: Improvement of Signal-to-Noise Ratio”, The International Society for Optical Engineering, USA, vol. 3915, 2000.Applicant
- Ballif, J. et al., “Rapid and Scalable Scans at 21 m/s in optical Low-Coherence Reflectometry”, Optics Letters, vol. 22, pp. 757-759, Jun. 1997.Applicant
- Barfuss H. et al., “Modified Optical Frequency-Domain Reflectometry with High Spatial-Resolution for Components of Integrated Optic Systems”, Journal of Lightwave Technology, vol. 7, pp. 3-10, Jan. 1989.Applicant
- Beaud, P. et al., “Optical Reflectometry with Micrometer Resolution for the Investigation of Integrated Optical-Devices”, Leee Journal of Quantum Electronics, vol. 25, pp. 755-759, Apr. 1989.Applicant
- Bouma, Brett et al., “Power-Efficient Nonreciprocal Interferometer and Linear-Scanning Fiber-Optic Catheter for Optical Coherence Tomography”, Optics Letters, vol. 24, pp. 531-533, Apr. 1999.Applicant
- Brinkmeyer, E. et al., “Efficient Algorithm for Non-Equidistant Interpolation of Sampled Data”, Electronics Letters, vol. 28, p. 693, Mar. 1992.Applicant
- Brinkmeyer, E. et al., “High-Resolution OCDR in Dispersive Wave-Guides”, Electronics Letters, vol. 26, pp. 413-414, Mar. 1990.Applicant
- Chinn, S.R. et al., “Optical Coherence Tomography Using a Frequency-Tunable Optical Source”, Optics Letters, vol. 22, pp. 340-342, Mar. 1997.Applicant
- Danielson, B.L. et al., “Absolute Optical Ranging Using Low Coherence Interferometry”, Applied Optics, vol. 20, p. 2975, Jul. 1991.Applicant
- Dorrer, C. et al., “Spectral Resolution and Sampling Issues in Fourier-Transform Spectral Interferometry”, Journal of the Optical Society of America B-Optical Physics, vol. 17, pp. 1795-1802, Oct. 2000.Applicant
- Dudley, J.M. et al., “Cross-Correlation Frequency Resolved Optical Gating Analysis of Broadband Continuum Generation in Photonic Crystal Fiber: Simulations and Experiments”, Optics Express, vol. 10, p. 1215, Oct. 2002.Applicant
- Eickhoff, W. et al., “Optical Frequency-Domain Reflectometry in Single-Mode Fiber”, Applied Physics Letters, vol. 39, pp. 693-695, 1981.Applicant
- Fercher, Adolf “Optical Coherence Tomography”, Journal of Biomedical Optics, vol. 1, pp. 157-173, Apr. 1996.Applicant
- Ferreira, L.A. et al., “Polarization-Insensitive Fiberoptic White-Light Interferometry”, Optics Communications, vol. 114, pp. 386-392, Feb. 1995.Applicant
- Fujii, Yohji, “High-Isolation Polarization-Independent Optical Circulator”, Journal of Lightwave Technology, vol. 9, pp. 1239-1243, Oct. 1991.Applicant
- Glance, B., “Polarization Independent Coherent Optical Receiver”, Journal of Lightwave Technology, vol. LT-5, p. 274, Feb. 1987.Applicant
- Glombitza, U., “Coherent Frequency-Domain Reflectometry for Characterization of Single-Mode Integrated-Optical Wave-Guides”, Journal of Lightwave Technology, vol. 11, pp. 1377-1384, Aug. 1993.Applicant
- Golubovic, B. et al., “Optical Frequency-Domain Reflectometry Using Rapid Wavelength Tuning of a Cr4+:Forsterite Laser”, Optics Letters, vol. 11, pp. 1704-1706, Nov. 1997.Applicant
- Haberland, U. H. P. et al., “Chirp Optical Coherence Tomography of Layered Scattering Media”, Journal of Biomedical Optics, vol. 3, pp. 259-266, Jul. 1998.Applicant
- Hammer, Daniel X. et al., “Spectrally Resolved White-Light Interferometry for Measurement of Ocular Dispersion”, Journal of the Optical Society of America A-Optics Image Science and Vision, vol. 16, pp. 2092-2102, Sep. 1999.Applicant
- Harvey, K. C. et al., “External-Cavity Diode-Laser Using a Grazing-Incidence Diffraction Grating”, Optics Letters, vol. 16, pp. 910-912, Jun. 1991.Applicant
- Hausler, Gerd et al., “‘Coherence Radar’ and ‘Spectral Radar’ New Tools for Dermatological Diagnosis”, Journal of Biomedical Optics, vol. 3, pp. 21-31, Jan. 1998.Applicant
- Hee, Michael R. et al., “Polarization-Sensitive Low-Coherence Reflectometer for Birefringence Characterization and Ranging”, Journal of the Optical Society of America B (Optical Physics), vol. 9, p. 903-908, Jun. 1992.Applicant
- Hotate Kazuo et al., “Optical Coherence Domain Reflectometry by Synthesis of Coherence Function”, Journal of Lightwave Technology, vol. 11, pp. 1701-1710, Oct. 1993.Applicant
- Inoue, Kyo et al., “Nearly Degenerate 4-Wave-Mixing in a Traveling-Wave Semiconductor-Laser Amplifier”, Applied Physics Letters, vol. 51, pp. 1051-1053, 1987.Applicant
- Ivanov, A. P. et al., “New Method for High-Range Resolution Measurements of Light Scattering in Optically Dense Inhomogeneous Media”, Optics Letters, vol. 1, pp. 226-228, Dec. 1977.Applicant
- Ivanov, A. P. et al., “Interferometric Study of the Spatial Structure of a Light-Scattering Medium”, Journal of Applied Spectroscopy, vol. 28, pp. 518-525, 1978.Applicant
- Kazovsky, L. G. et al., “Heterodyne Detection Through Rain, Snow, and Turbid Media: Effective Receiver Size at Optical Through Millimeter Wavelenghths”, Applied Optics, vol. 22, pp. 706-710, Mar. 1983.Applicant
- Kersey, A. D. et al., “Adaptive Polarization Diversity Receiver Configuration for Coherent Optical Fiber Communications”, Electronics Letters, vol. 25, pp. 275-277, Feb. 1989.Applicant
- Kohlhaas, Andreas et al., “High-Resolution OCDR for Testing Integrated-Optical Waveguides: Dispersion-Corrupted Experimental Data Corrected by a Numerical Algorithm”, Journal of Lightwave Technology, vol. 9, pp. 1493-1502, Nov. 1991.Applicant
- Larkin, Kieran G., “Efficient Nonlinear Algorithm for Envelope Detection in White Light Interferometry”, Journal of the Optical Society of America A-Optics Image Science and Vision, vol. 13, pp. 832-843, Apr. 1996.Applicant
- Leitgeb, R. et al., “Spectral measurement of Absorption by Spectroscopic Frequency-Domain Optical Coherence Tomography”, Optics Letters, vol. 25, pp. 820-822, Jun. 2000.Applicant
- Lexer, F. et al., “Wavelength-Tuning Interferometry of Intraocular Distances”, Applied Optics,vol. 36, pp. 6548-6553, Sep. 1997.Applicant
- Mitsui, Takahisa, “Dynamic Range of Optical Reflectometry with Spectral Interferometry”, Japanese Journal of Applied Physics Part 1—Regular Papers Short Notes & Review Papers, vol. 38, pp. 6133-6137, 1999.Applicant
- Naganuma, Kazunori et al., “Group-Delay Measurement Using the Fourier-Transform of an Interferometric Cross-Correlation Generated by White Light”, Optics Letters, vol. 15, pp. 393-395, Apr. 1990.Applicant
- Okoshi,Takanori, “Polarization-State Control Schemes for Heterodyne or Homodyne Optical Fiber Communications”, Journal of Lightwave Technology, vol. LT-3, pp. 1232-1237, Dec. 1995.Applicant
- Passy, R. et al., “Experimental and Theoretical Investigations of Coherent OFDR with Semiconductor-Laser Sources”, Journal of Lightwave Technology, vol. 12, pp. 1622-1630, Sep. 1994.Applicant
- Podoleanu, Adrian G., “Unbalanced Versus Balanced Operation in an Optical Coherence Tomography System”, Applied Optics, vol. 39, pp. 173-182, Jan. 2000.Applicant
- Price, J. H. V. et al., “Tunable, Femtosecond Pulse Source Operating in the Range 1.06-1.33 mu m Based on an Yb3+-doped Holey Fiber Amplifier”, Journal of the Optical Society of America B-Optical Physics, vol. 19, pp. 1286-1294, Jun. 2002.Applicant
- Schmitt, J. M. et al, “Measurement of Optical-Properties O Biological Tissues By Low-Coherence Reflectometry”, Applied Optics, vol. 32, pp. 6032-6042, Oct. 1993.Applicant
- Silberberg, Y. et al., “Passive-Mode Locking of a Semiconductor Diode-Laser”, Optics Letters, vol. 9, pp. 507-509, Nov. 1984.Applicant
- Smith, L. Montgomery et al., “Absolute Displacement Measurements Using Modulation of the Spectrum of White-Light in a Michelson Interferometer”, Applied Optics, vol. 28, pp. 3339-3342, Aug. 1989.Applicant
- Sonnenschein, C. M. et al., “Signal-To-Noise Relationships for Coaxial Systems that Heterodyne Backscatter from Atmosphere”, Applied Optics, vol. 10, pp. 1600-1604, Jul. 1971.Applicant
- Sorin, W. V. et al., “Measurement of Rayleigh Backscattering at 1.55 mu m with 32 mu m Spatial Resolution”, IEEE Photonics Technology Letters, vol. 4, pp. 374-376, Apr. 1992.Applicant
- Sorin, W. V. et al., “A Simple Intensity Noise-Reduction Technique for Optical Low-Coherence Reflectometry”, IEEE Photonics Technology Letters, vol. 4, pp. 1404-1406, Dec. 1992.Applicant
- Swanson, E. A. et al., “High-Speed Optical Coherence Domair Reflectometry”, Optics Letters, vol. 17, pp. 151-153, Jan. 1992.Applicant
- Takada, K. et al., “High-Resolution OFDR with Incorporated Fiberoptic Frequency Encoder”, IEEE Photonics Technology Letters, vol. 4, pp. 1069-1072, Sep. 1992.Applicant
- “Narrow-Band light Source with Acoustooptic Tunable Filter for Optical Low-Coherence Reflectometry”, by Takada, Kazumasa et al., IEEE Photonics Technology Letters, vol. 8, pp. 658-660, May 1996.Applicant
- Takada, Kazumasa et al., “New Measurement System for Fault Location in Optical Wave-Guide Devices Based on an Interometric-Technique”, Applied Optics, vol. 26, pp. 1603-1606, May 1987.Applicant
- Tateda, Mitsuhiro et al., “Interferometric Method for Chromatic Dispersion Measurement in a Single-Mode Optical Fiber”, IEEE Journal of Quantum Electronics, vol. 17, pp. 404-407, Mar. 1981.Applicant
- Toide, M. et al., “Two-Dimensional Coherent Detection Imaging in Multiple Scattering Media Based the Directional Resolution Capability of the Optical Heterodyne Method”, Applied Physics B (Photophysics and Laser Chemistry), vol. B52, pp. 391-394, 1991.Applicant
- Trutna, W. R. et al., “Continuously Tuned External-Cavity Semiconductor-Laser”, Journal of Lightwave Technology, vol. 11, pp. 1279-1286, Aug. 1993.Applicant
- Uttam, Deepak et al., “Precision Time Domain Reflectometry in Optical Fiber Systems Using a Frequency Modulated Continuous Wave Ranging Technique”, Journal of Lightwave Technology, vol. 3, pp. 971-977, Oct. 1985.Applicant
- Von Der Weid, J. P. et al., “On the Characterization with Optical Fiber Network Components with Optical Frequency Domain Reflectometry”, Journal of Lightwave Technology, vol. 15, pp. 1131-1141, Jul. 1997.Applicant
- Wysocki, P.F. et al., “Broad-Spectrum, Wavelength-Swept, Erbium-Doped Fiber Laser at 1.55-Mu-M”, Optics Letters, vol. 15, pp. 879-881, Aug. 1990.Applicant
- Youngquist, Robert C. et al., “Optical Coherence-Domain Reflectometry—A New Optical Evaluation Technique”, Optics Letters, vol. 12, pp. 158-160, Mar. 1987.Applicant
- Yun, S. H. et al., “Wavelength-Swept Fiber Laser with Frequency Shifted Feedback and Resonantly Swept Intra-Cavity Acoustooptic Tunable Filter”, IEEE Journal of Selected Topics in Quantum Electronics, vol. 3, pp. 1087-1096, Aug. 1997.Applicant
- Yun, S. H. et al., “Interrogation of Fiber Grating Sensor Arrays with a Wavelength-Swept Fiber Laser”, Optics Letters, vol. 23, pp. 843-845, Jun. 1998.Applicant
- Yung, K. M., “Phase-Domain Processing of Optical Coherence Tomography Images”, Journal of Biomedical Optics, vol. 4, pp. 125-136, Jan. 1999.Applicant
- Zhou, Xiao-Qun et al., “Extended-Range FMCW Reflectometry Using an optical Loop with a Frequency Shifter”, IEEE Photonics Technology Letters, vol. 8, pp. 248-250, Feb. 1996.Applicant
- Zorabedian, Paul et al., “Tuning Fidelity of Acoustooptically Controlled External Cavity Semiconductor-Lasers”, Journal of Lightwave Technology, vol. 13, pp. 62-66, Jan. 1995.Applicant
- Victor S. Y. Lin et al., “A Porous Silicon-Based Optical Interferometric Biosensor”, Science Magazine, vol. 278, pp. 840-843, Oct. 31, 1997.Applicant
- Acioli, L. H., M. Ulman, et al. (1991). “Femtosecond Temporal Encoding in Barium-Titanate.” Optics Letters 16(24): 1984-1986.Applicant
- Aigouy, L., A. Lahrech, et al. (1999). “Polarization effects in apertureless scanning near-field optical microscopy: an experimental study.” Optics Letters 24(4): 187-189.Applicant
- Akiba, M., K. P. Chan, et al. (2003). “Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras.” Optics Letters 28(10): 816-818.Applicant
- Akkin, T., D. P. Dave, et al. (2004). “Detection of neural activity using phase-sensitive optical low-coherence reflectometry.” Optics Express 12(11): 2377-2386.Applicant
- Akkin, T., D. P. Dave, et al. (2003). “Surface analysis using phase sensitive optical low coherence reflectometry.” Lasers in Surgery and Medicine: 4-4.Applicant
- Akkin, T., D. P. Dave, et al. (2003). “Imaging tissue response to electrical and photothermal stimulation with nanometer sensitivity.” Lasers in Surgery and Medicine 33(4): 219-225.Applicant
- Akkin, T., T. E. Milner, et al. (2002). “Phase-sensitive measurement of birefringence change as an indication of neural functionality and diseases.” Lasers in Surgery and Medicine: 6-6.Applicant
- Andretzky, P., Lindner, M.W., Herrmann, J.M., Schultz, A., Konzog, M., Kiesewetter, F., Haeusler, G. (1999). “Optical coherence tomography by ‘spectral radar’: Dynamic range estimation and in vivo measurements of skin.” Proceedings of SPIE—The International Society for Optical Engineering 3567: pp. 78-87.Applicant
- Antcliff, R. J., T. J. ffytche, et al. (2000). “Optical coherence tomography of melanocytoma.” American Journal of Ophthalmology 130(6): 845-7.Applicant
- Antcliff, R. J., M. R. Stanford, et al. (2000). “Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis.” Ophthalmology 107(3): 593-9.Applicant
- Anvari, B., T. E. Milner, et al. (1995). “Selective Cooling of Biological Tissues—Application for Thermally Mediated Therapeutic Procedures.” Physics in Medicine and Biology 40(2): 241-252.Applicant
- Anvari, B., B. S. Tanenbaum, et al. (1995). “A Theoretical-Study of the Thermal Response of Skin to Cryogen Spray Cooling and Pulsed-Laser Irradiation—Implications for Treatment of Port-Wine Stain Birthmarks.” Physics in Medicine and Biology 40(9): 1451-1465.Applicant
- Arend, O., M. Ruffer, et al. (2000). “Macular circulation in patients with diabetes mellitus with and without arterial hypertension.” British Journal of Ophthalmology 84(12): 1392-1396.Applicant
- Arimoto, H. and Y. Ohtsuka (1997). “Measurements of the complex degree of spectral coherence by use of a wave-front-folded interferometer.” Optics letters 22(13): 958-960.Applicant
- Azzolini, C., F. Patelli, et al. (2001). “Correlation between optical coherence tomography data and biomicroscopic interpretation of idiopathic macular hole.” American Journal of Ophthalmology 132(3): 348-55.Applicant
- Baba, T., K. Ohno-Matsui, et al. (2002). “Optical coherence tomography of choroidal neovascularization in high myopia.” Acta Ophthalmoloqica Scandinavica 80(1): 82-7.Applicant
- Bail, M. A. H., Gerd; Herrmann, Juergen M.; Lindner, Michael W.; Ringler, R. (1996). “Optical coherence tomography with the “spectral radar”: fast optical analysis in volume scatterers by short-coherence interferometry.” Proc. SPIE , 2925: p. 298-303.Applicant
- Baney, D. M. and W. V. Sorin (1993). “Extended-Range Optical Low-Coherence Reflectometry Using a Recirculating Delay Technique.” Ieee Photonics Technology Letters 5(9): 1109-1112.Applicant
- Baney, D. M., B. Szafraniec, et al. (2002). “Coherent optical spectrum analyzer.” Ieee Photonics Technology Letters 14(3): 355-357.Applicant
- Barakat, R. (1981). “Bilinear Constraints between Elements of the 4by4 Mueller-Jones Transfer-Matrix of Polarization Theory.” Optics Communications 38(3): 159-161.Applicant
- Barakat, R. (1993). “Analytic Proofs of the Arago-Fresnel Laws for the Interference of Polarized-Light.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(1): 180-185.Applicant
- Barbastathis, G. and D. J. Brady (1999). “Multidimensional tomographic imaging using volume holography.” Proceedings of the Ieee 87(12): 2098-2120.Applicant
- Bardal, S., A. Kamal, et al. (1992). “Photoinduced Birefringence in Optical Fibers—a Comparative-Study of Low-Birefringence and High-Birefringence Fibers.” Optics Letters 17(6): 411-413.Applicant
- Barsky, S. H., S. Rosen, et al. (1980). “Nature and Evolution of Port Wine Stains—Computer-Assisted Study.” Journal of Investigative Dermatology 74(3): 154-157.Applicant
- Barton, J. K., J. A. Izatt, et al. (1999). “Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images.” Dermatology 198(4): 355-361.Applicant
- Barton, J. K., A. Rollins, et al. (2001). “Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling.” Physics in Medicine and Biology 46.Applicant
- Barton, J. K., A. J. Welch, et al. (1998). “Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography.” Optics Express 3.Applicant
- Bashkansky, M., M. D. Duncan, et al. (1997). “Subsurface defect detection in ceramics by high-speed high-resolution optical coherent tomography.” Optics Letters 22 (1): 61-63.Applicant
- Bashkansky, M. and J. Reintjes (2000). “Statistics and reduction of speckle in optical coherence tomography.” Optics Letters 25(8): 545-547.Applicant
- Baumgartner, A., S. Dichtl, et al. (2000). “Polarization-sensitive optical coherence tomography of dental structures.” Caries Research 34(1): 59-69.Applicant
- Baumgartner, A., C. K. Hitzenberger, et al. (2000). “Resolution-improved dual-beam and standard optical coherence tomography: a comparison.” Graefes Archive for Clinical and Experimental Ophthalmology 238(5): 385-392.Applicant
- Baumgartner, A., C. K. Hitzenberger, et al. (1998). “Signal and resolution enhancements in dual beam optical coherence tomography of the human eye.” Journal of Biomedical Optics 3(1): 45-54.Applicant
- Beaurepaire, E., P. Gleyzes, et at. (1998). Optical coherence microscopy for the in-depth study of biological structures: System based on a parallel detection scheme, Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Beaurepaire, E., L. Moreaux, et al. (1999). “Combined scanning optical coherence and two-photon-excited fluorescence microscopy.” Optics Letters 24(14): 969-971.Applicant
- Bechara, F. G., T. Gambichler, et al. (2004). “Histomorphologic correlation with routine histology and optical coherence tomography.” Skin Research and Technology 10 (3): 169-173.Applicant
- Bechmann, M., M. J. Thiel, et al. (2000). “Central corneal thickness determined with optical coherence tomography in various types of glaucoma. [see comments].” British Journal of Ophthalmology 84(11): 1233-7.Applicant
- Bek, T. and M. Kandi (2000). “Quantitative anomaloscopy and optical coherence tomography scanning in central serous chorioretinopathy.” Acta Ophthalmologica Scandinavica 78(6): 632-7.Applicant
- Benoit, A. M., K. Naoun, et al. (2001). “Linear dichroism of the retinal nerve fiber layer expressed with Mueller matrices.” Applied Optics 40(4): 565-569.Applicant
- Bicout, D., C. Brosseau, et al. (1994). “Depolarization of Multiply Scattered Waves by Spherical Diffusers—Influence of the Size Parameter.” Physical Review E 49(2): 1767-1770.Applicant
- Blanchot, L., M. Lebec, et al. (1997). Low-coherence in depth microscopy for biological tissues imaging: Design of a real time control system. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Blumenthal, E. Z. and R. N. Weinreb (2001). “Assessment of the retinal nerve fiber layer in clinical trials of glaucoma neuroprotection. [Review] [36 refs].” Survey of Ophthalmology 45(Suppl 3): S305-12; discussion S332-4.Applicant
- Blumenthal, E. Z., J. M. Williams, et al. (2000). “Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography.” Ophthalmology 107(12): 2278-82.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1996). “Imaging developing neural morphology using optical coherence tomography.” Journal of Neuroscience Methods 70.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1997). “Forward-imaging instruments for optical coherence tomography.” Optics Letters 22.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1998). “Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography.” Radiology 208: 81-86.Applicant
- Boppart, S. A., J. Herrmann, et al. (1999). “High-resolution optical coherence tomography-guided laser ablation of surgical tissue.” Journal of Surgical Research 82(2): 275-84.Applicant
- Bouma, B. E. and J. G. Fujimoto (1996). “Compact Kerr-lens mode-locked resonators.” Optics Letters 21.Applicant
- Bouma, B. E., L. E. Nelson, et al. (1998). “Optical coherence tomographic imaging of human tissue at 1.55 mu m and 1.81 mu m using Er and Tm-doped fiber sources.” Journal of Biomedical Optics 3.Applicant
- Bouma, B. E., M. Ramaswamy-Paye, et al. (1997). “Compact resonator designs for mode-locked solid-state lasers.” Applied Physics B (Lasers and Optics) B65.Applicant
- Bouma, B. E. and G. J. Tearney (2002). “Clinical imaging with optical coherence tomography.” Academic Radiology 9(8): 942-953.Applicant
- Bouma, B. E., G. J. Tearney, et al. (1996). “Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography.” Optics Letters 21(22): 1839.Applicant
- Bouma, B. E., G. J. Tearney, et al. (2000). “High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography.” Gastrointestinal Endoscopy 51(4): 467-474.Applicant
- Bouma, B. E., G. J. Tearney, et al. (2003). “Evaluation if intracoronary stenting by intravascular optical coherence tomography.” Heart 89(3): 317-320.Applicant
- Bourquin, S., V. Monterosso, et al. (2000). “Video-rate optical low-coherence reflectometry based on a linear smart detector array.” Optics Letters 25(2): 102-104.Applicant
- Bourquin, S., P. Seitz, et al. (2001). “Optical coherence topography based on a two-dimensional smart detector array.” Optics Letters 26(8): 512-514.Applicant
- Bouzid, A., M. A. G. Abushagur, et al. (1995). “Fiber-optic four-detector polarimeter.” Optics Communications 118(3-4): 329-334.Applicant
- Bowd, C., R. N. Weinreb, et al. (2000). “The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography.” Archives of Ophthalmology 118(1): 22-6.Applicant
- Bowd, C., L. M. Zangwill, et al. (2001). “Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function.” Investigative Ophthalmology & Visual Science 42(9): 1993-2003.Applicant
- Bowd, C., L. M. Zangwill, et al. (2002). “Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender.” Journal of the Optical Society of America, A, Optics, Image Science, & Vision 19(1): 197-207.Applicant
- Brand, S., J. M. Poneros, et al. (2000). “Optical coherence tomography in the gastrointestinal tract.” Endoscopy 32(10): 796-803.Applicant
- Brezinski, M. E. and J. G. Fujimoto (1999). “Optical coherence tomography: high-resolution imaging in nontransparent tissue.” IEEE Journal of Selected Topics in Quantum Electronics 5(4): 1185-1192.Applicant
- Brezinski, M. E., G. J. Tearney, et al. (1996). “Imaging of coronary artery microstructure (in vitro) with optical coherence tomography.” American Journal of Cardiology 77 (1): 92-93.Applicant
- Brezinski, M. E., G. J. Tearney, et al. (1996). “Optical coherence tomography for optical biopsy—Properties and demonstration of vascular pathology.” Circulation 93(6): 1206-1213.Applicant
- Brezinski, M. E., G. J. Tearney, et al. (1997). “Assessing atherosclerotic plaque morphology: Comparison of optical coherence tomography and high frequency intravascular ultrasound.” Heart 77(5): 397-403.Applicant
- Brink, H. B. K. and G. J. Vanblokland (1988). “Birefringence of the Human Foveal Area Assessed Invivo with Mueller-Matrix Ellipsometry.” Journal of the Optical Society of America a—Optics Image Science and Vision 5(1): 49-57.Applicant
- Brosseau, C. and D. Bicout (1994). “Entropy Production in Multiple-Scattering of Light by a Spatially Random Medium.” Physical Review E 50(6): 4997-5005.Applicant
- Burgoyne, C. F., D. E. Mercante, et al. (2002). “Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.” Ophthalmology 109(3): 455-66.Applicant
- Candido, R. and T. J. Allen (2002). “Haemodynamics in microvascular complications in type 1 diabetes.” Diabetes-Metabolism Research and Reviews 18(4): 286-304.Applicant
- Cense, B., T. C. Chen, et al. (2004). “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography.” Investigative Ophthalmology & Visual Science 45(8): 2606-2612.Applicant
- Cense, B., N. Nassif, et al. (2004). “Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography.” Optics Express 12(11): 2435-2447.Applicant
- Chance, B., J. S. Leigh, et al. (1988). “Comparison of Time-Resolved and Time-Unresolved Measurements of Deoxyhemoglobin in Brain.” Proceedings of the National Academy of Sciences of the United States of America 85(14): 4971-4975.Applicant
- Chang, E. P., D. A. Keedy, et al. (1974). “Ultrastructures of Rabbit Corneal Stroma—Mapping of Optical and Morphological Anisotropies.” Biochimica Et Biophysica Acta 343(3): 615-626.Applicant
- Chartier, T., A. Hideur, et al. (2001). “Measurement of the elliptical birefringence of single-mode optical fibers.” Applied Optics 40(30): 5343-5353.Applicant
- Chauhan, B. C., J. W. Blanchard, et al. (2000). “Technique for Detecting Serial Topographic Changes in the Optic Disc and Peripapillary Retina Using Scanning Laser Tomograph.” Invest Ophthalmol Vis Sci 41: 775-782.Applicant
- Chen, Z. P., T. E. Milner, et al. (1997). “Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media.” Optics Letters 22(1): 64-66.Applicant
- Chen, Z. P., T. E. Milner, et al. (1997). “Noninvasive imaging of in vivo blood flor velocity using optical Doppler tomography.” Optics Letters 22(14): 1119-1121.Applicant
- Chen, Z. P., Y. H. Zhao, et al. (1999). “Optical Doppler tomography.” Ieee Journal of Selected Topics in Quantum Electronics 5(4): 1134-1142.Applicant
- Cheong, W. F., S. A. Prahl, et al. (1990). “A Review of the Optical-Properties of Biological Tissues.” Ieee Journal of Quantum Electronics 26(12): 2166-2185.Applicant
- Chernikov, S. V., Y. Zhu, et al. (1997). “Supercontinuum self-Q-switched ytterbium fiber laser.” Optics Letters 22(5): 298-300.Applicant
- Cho, S. H., B. E. Bouma, et al. (1999). “Low-repetition-rate high-peak-power Kerr-lens mode-locked Ti:AI/sub 2/0/sub 3/ laser with a multiple-pass cavity.” Optics Letters 24(6): 417-419.Applicant
- Choma, M. A., M. V. Sarunic, et al. (2003). “Sensitivity advantage of swept source and Fourier domain optical coherence tomography.” Optics Express 11(18): 2183-2189.Applicant
- Choma, M. A., C. H. Yang, et al. (2003). “Instantaneous quadrature low-coherence interferometry with 3×3 fiber-optic couplers.” Optics Letters 28(22): 2162-2164.Applicant
- Choplin, N. T. and D. C. Lundy (2001). “The sensitivity and specificity of scanning laser polarimetry in the detection of glaucoma in a clinical setting.” Ophthalmology 108 (5): 899-904.Applicant
- Christens Barry, W. A., W. J. Green, et al. (1996). “Spatial mapping of polarized light transmission in the central rabbit cornea.” Experimental Eye Research 62(6): 651-662.Applicant
- Chvapil, M., D. P. Speer, et al. (1984). “Identification of the depth of burn injury by collagen stainability.” Plastic & Reconstructive Surgery 73(3): 438-41.Applicant
- Cioffi, G. A. (2001). “Three common assumptions about ocular blood flow and glaucoma.” Survey of Ophthalmology 45: S325-S331.Applicant
- Coleman, A. L. (1999). “Glaucoma.” Lancet 354(9192): 1803-10.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (1998). “Comparison of Glaucomatous Progression Between Untreated Patients With Normal Tension Glaucoma and Patients with Therapeutically Reduced Intraocular Pressures.” Am J Ophthalmol 126: 487-97.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (1998). “The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma.” Am J Ophthalmol 126: 498-505.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (2001). “Natural History of Normal-Tension Glaucoma.” Ophthalmology 108: 247-253.Applicant
- Colston, B. W., M. J. Everett, et al. (1998). “Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography.” Applied Optics 37(16): 3582-3585.Applicant
- Colston, B. W., U. S. Sathyam, et al. (1998). “Dental OCT.” Optics Express 3(6): 230-238.Applicant
- Congdon, N. G., D. S. Friedman, et al. (2003). “Important causes of visual impairment in the world today.” Jama—Journal of the American Medical Association 290(15): 2057-2060.Applicant
- Cregan, R. F., B. J. Mangan, et al. (1999). “Single-mode photonic band gap guidance of light in air.” Science 285(5433): 1537-1539.Applicant
- DalMolin, M., A. Galtarossa, et al. (1997). “Experimental investigation of linear polarization in high-birefringence single-mode fibers.” Applied Optics 36(12): 2526-2528.Applicant
- Danielson, B. L. and C. D. Whittenberg (1987). “Guided-Wave Reflectometry with Micrometer Resolution.” Applied Optics 26(14): 2836-2842.Applicant
- Dave, D. P. and T. E. Milner (2000). “Doppler-angle measurement in highly scattering media.” Optics Letters 25(20): 1523-1525.Applicant
- De Boer, J. F., T. E. Milner, et al. (1998). Two dimensional birefringence imaging in biological tissue using phase and polarization sensitive optical coherence tomography. Trends in Optics and Photonics (TOPS): Advances in Optical Imaging and Photon Migration, Orlando, USA, Optical Society of America, Washington, DC 1998.Applicant
- De Boer, J. F., C. E. Saxer, et al. (2001). “Stable carrier generation and phase-resolved digital data processing in optical coherence tomography.” Applied Optics 40(31): 5787-5790.Applicant
- Degroot, P. and L. Deck (1993). “3-Dimensional Imaging by Sub-Nyquist Sampling of White-Light Interferograms.” Optics Letters 18(17): 1462-1464.Applicant
- Denk, W., J. H. Strickler, et al. (1990). “2-Photon Laser Scanning Fluorescence Microscopy.” Science 248(4951): 73-76.Applicant
- Descour, M. R., A. H. O. Karkkainen, et al. (2002). “Toward the development of miniaturized Imaging systems for detection of pre-cancer.” Ieee Journal of Quantum Electronics 38(2): 122-130.Applicant
- Dettwiller, L. (1997). “Polarization state interference: A general investigation.” Pure and Applied Optics 6(1): 41-53.Applicant
- DiCarlo, C. D., W. P. Roach, et al. (1999). “Comparison of optical coherence tomography imaging of cataracts with histopathology.” Journal of Biomedical Optics 4.Applicant
- Ding, Z., Y. Zhao, et al. (2002). “Real-time phase-resolved optical coherence tomography and optical Doppler tomography.” Optics Express 10(5): 236-245.Applicant
- Dobrin, P. B. (1996). “Effect of histologic preparation on the cross-sectional area of arterial rings.” Journal of Surgical Research 61(2): 413-5.Applicant
- Donohue, D. J., B. J. Stoyanov, et al. (1995). “Numerical Modeling of the Corneas Lamellar Structure and Birefringence Properties.” Journal of the Optical Society of America a—Optics Image Science and Vision 12(7): 1425-1438.Applicant
- Doornbos, R. M. P., R. Lang, et al. (1999). “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy.” Physics in Medicine and Biology 44(4): 967-981.Applicant
- Drexler, W., A. Baumgartner, et al. (1997). “Biometric investigation of changes in the anterior eye segment during accommodation.” Vision Research 37(19): 2789-2800.Applicant
- Drexler, W., A. Baumgartner, et al. (1997). “Submicrometer precision biometry of the anterior segment of the human eye.” Investigative Ophthalmology & Visual Science 38(7): 1304-1313.Applicant
- Drexler, W., A. Baumgartner, et al. (1998). “Dual beam optical coherence tomography: signal identification for ophthalmologic diagnosis.” Journal of Biomedical Optics 3 (1): 55-65.Applicant
- Drexler, W., O. Findl, et al. (1998). “Partial coherence interferometry: A novel approach to biometry in cataract surgery.” American Journal of Ophthalmology 126(4): 524-534.Applicant
- Drexler, W., O. Findl, et al. (1997). “Clinical feasibility of dual beam optical coherence topography and tomography for ophthalmologic diagnosis.” Investigative Ophthalmology & Visual Science 38(4): 1038-1038.Applicant
- Drexler, W., C. K. Hitzenberger, et al. (1998). “Investigation of dispersion effects in ocular media by multiple wavelength partial coherence interferometry.” Experimental Eye Research 66(1): 25-33.Applicant
- Drexler, W., C. K. Hitzenberger, et al. (1996). “(Sub)micrometer precision biometry of the human eye by optical coherence tomography and topography.” Investigative Ophthalmology & Visual Science 37(3): 4374-4374.Applicant
- Drexler, W., C. K. Hitzenberger, et aI. (1995). “Measurement of the Thickness of Fundus Layers by Partial Coherence Tomography.” Optical Engineering 34(3): 701-710.Applicant
- Drexler, W., U. Morgner, et al. (2001). “Ultrahigh-resolution ophthalmic optical coherence tomography.” Nature Medicine 7(4): 502-507.Applicant
- Drexler, W., U. Morgner, et al. (2001). “Ultrahigh-resolution ophthalmic optical coherence tomography. [erratum appears in Nat Med May 2001;7(5):636.].” Nature Medicine 7(4): 502-7.Applicant
- Drexler, W., H. Sattmann, et al. (2003). “Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography.” Archives of Ophthalmology 121(5): 695-706.Applicant
- Drexler, W., D. Stamper, et al. (2001). “Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis.” Journal of Rheumatology 28(6): 1311-8.Applicant
- Droog, E. J., W. Steenbergen, et al. (2001). “Measurement of depth of burns by laser Doppler perfusion imaging.” Burns 27(6): 561-8.Applicant
- Dubois, A., K. Grieve, et al. (2004). “Ultrahigh-resolution full-field optical coherence tomography.” Applied Optics 43(14): 2874-2883.Applicant
- Dubois, A., L. Vabre, et al. (2002). “High-resolution full-field optical coherence tomography with a Linnik microscope.” Applied Optics 41(4): 805-812.Applicant
- Ducros, M., M. Laubscher, et al. (2002). “Parallel optical coherence tomography in scattering samples using a two-dimensional smart-pixel detector array.” Optics Communications 202(1-3): 29-35.Applicant
- Ducros, M. G., J. D. Marsack, et al. (2001). “Primate retina imaging with polarization-sensitive optical coherence tomography.” Journal of the Optical Society of America a—Optics Image Science and Vision 18(12): 2945-2956.Applicant
- Duncan, A., J. H. Meek, et al. (1995). “Optical Pathlength Measurements on Adult Head, Calf and Forearm and the Head of the Newborn-Infant Using Phase-Resolved Optical Spectroscopy.” Physics in Medicine and Biology 40(2): 295-304.Applicant
- Eigensee, A., G. Haeusler, et al. (1996). “New method for short-coherence interferometry in human skin (in vivo) and in solid volume scatterers.” Proceedings of SPIE—The International Society for Optical Engineerinq 2925: 169-178.Applicant
- Eisenbeiss, W., J. Marotz, et al. (1999). “Reflection-optical multispectral imaging for method for objective determination of burn depth.” Burns 25(8): 697-704.Applicant
- Elbaum, M., M. King, et al. (1972). “Wavelength-Diversity Technique for Reduction of Speckle Size.” Journal of the Optical Society of America 62(5): 732-&.Applicant
- Ervin, J. C., H. G. Lemij, et al. (2002). “Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomogrphy in the LSU Experimental Glaucoma (LEG) Study.” Ophthalmology 109(3): 467-81.Applicant
- Essenpreis, M., C. E. Elwell, et al. (1993). “Spectral Dependence of Temporal Point Spread Functions in Human Tissues.” Applied Optics 32(4): 418-425.Applicant
- Eun, H. C. (1995). “Evaluation of skin blood flow by laser Doppler flowmetry. [Review] [151 refs].” Clinics in Dermatology 13(4): 337-47.Applicant
- Evans, J. A., J. M. Poneros, et al. (2004). “Application of a histopathologic scoring system to optical coherence tomography (OCT) images to identify high-grade dysplasia in Barrett's esophagus.” Gastroenterology 126(4): A51-A51.Applicant
- Feldchtein, F. I., G. V. Gelikonov, et al. (1998). “In vivo OCT imaging of hard and soft tissue of the oral cavity.” Optics Express 3(6): 239-250.Applicant
- Feldchtein, F. I., G. V. Gelikonov, et al. (1998). “Endoscopic applications of optical coherence tomography.” Optics Express 3(6): 257-270.Applicant
- Fercher, A. F., W. Drexler, et al. (1997). “Optical ocular tomography.” Neuro-Ophthalmology 18(2): 39-49.Applicant
- Fercher, A. F., W. Drexler, et al. (1994). Measurement of optical distances by optical spectrum modulation. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., W. Drexler, et al. (2003). “Optical coherence tomography—principles and applications.” Reports on Progress in Physics 66(2): 239-303.Applicant
- Fercher, A. F., C. Hitzenberger, et al. (1991). “Measurement of Intraocular Optical Distances Using Partially Coherent Laser-Light.” Journal of Modern Optics 38(7): 1327-1333.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1996). Ocular partial coherence interferometry. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1993). “In-Vivo Optical Coherence Tomography.” American Journal of Ophthalmology 116(1): 113-115.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1994). In-vivo dual-beam optical coherence tomography. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1995). “Measurement of Intraocular Distances by Backscattering Spectral Interferometry.” Optics Communications 117(1-2): 43-48.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2000). “A thermal light source technique for optical coherence tomography.” Optics Communications 185(1-3): 57-64.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2001). “Numerical dispersion compensation for partial Coherence Interferometry and Optical Coherence Tomography.” Optics Express 9(12): 610-615.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2002). “Dispersion compensation for optical coherence tomography depth-scan signals by a numerical technique.” Optics Communications 204(1-6): 67-74.Applicant
- Fercher, A. F., H. C. Li, et al. (1993). “Slit Lamp Laser-Doppler Interferometer.” Lasers in Surgery and Medicine 13(4): 447-452.Applicant
- Fercher, A. F., K. Mengedoht, et at. (1988). “Eye-Length Measurement by Interferometry with Partially Coherent-Light.” Optics Letters 13(3): 186-188.Applicant
- Ferro, P., M. Haelterman, et al. (1991). “All-Optical Polarization Switch with Long Low-Birefringence Fiber.” Electronics Letters 27(16): 1407-1408.Applicant
- Fetterman, M. R., D. Goswami, et al. (1998). “Ultrafast pulse shaping: amplification and characterization.” Optics Express 3(10): 366-375.Applicant
- Findl, O., W. Drexler, et al. (2001). “Improved prediction of intraocular lens power using partial coherence interferometry.” Journal of Cataract and Refractive Surgery 27 (6): 861-867.Applicant
- Fork, R. L., C. H. B. Cruz, et al. (1987). “Compression of Optical Pulses to 6 Femtoseconds by Using Cubic Phase Compensation.” Optics Letters 12(7): 483-485.Applicant
- Foschini, G. J. and C. D. Poole (1991). “Statistical-Theory of Polarization Dispersion in Single-Mode Fibers.” Journal of Lightwave Technology 9(11): 1439-1456.Applicant
- Francia, C., F. Bruyere, et al. (1998). “PMD second-order effects on pulse propagation in single-mode optical fibers.” Ieee Photonics Technology Letters 10(12): 1739-1741.Applicant
- Fried, D., R. E. Glena, et al. (1995). “Nature of Light-Scattering in Dental Enamel and Dentin at Visible and near-Infrared Wavelengths.” Applied Optics 34(7): 1278-1285.Applicant
- Fujimoto, J. G., M. E. Brezinski, et al. (1995). “Optical Biopsy and Imaging Using Optical Coherence Tomography.” Nature Medicine 1(9): 970-972.Applicant
- Fukasawa, A. and H. Iijima (2002). “Optical coherence tomography of choroidal osteoma.” American Journal of Ophthalmology 133(3): 419-21.Applicant
- Fymat, A. L. (1981). “High-Resolution Interferometric Spectrophotopolarimetry.” Optical Engineering 20(1): 25-30.Applicant
- Galtarossa, A., L. Palmieri, et al. (2000). “Statistical characterization of fiber random birefringence.” Optics Letters 25(18): 1322-1324.Applicant
- Galtarossa, A., L. Palmieri, et al. (2000). “Measurements of beat length and perturbation length in long-single-mode fibers.” Optics Letters 25(6): 384-386.Applicant
- Gandjbakhche, A. H., P. Mills, et al. (1994). “Light-Scattering Technique for the Study of Orientation and Deformation of Red-Blood-Cells in a Concentrated Suspension.” Applied Optics 33(6): 1070-1078.Applicant
- Garcia, N. and M. Nieto-Vesperinas (2002). “Left-handed materials do not make a perfect lens.” Physical Review Letters 88(20).Applicant
- Gelikonov, V. M., G. V. Gelikonov, et al. (1995). “Coherent Optical Tomography of Microscopic Inhomogeneities in Biological Tissues.” Jetp Letters 61(2): 158-162.Applicant
- George, N. and A. Jain (1973). “Speckle Reduction Using Multiple Tones of Illumination.” Applied Optics 12(6): 1202-1212.Applicant
- Gibson, G. N., R. Klank, et al. (1996). “Electro-optically cavity-dumped ultrashort-pulse Ti:sapphire oscillator.” Optics Letters 21(14): 1055.Applicant
- Gil, J. J. (2000). “Characteristic properties of Mueller matrices.” Journal of the Optical Society of America a—Optics Image Science and Vision 17(2): 328-334.Applicant
- Gil, J. J. and E. Bernabeu (1987). “Obtainment of the Polarizing and Retardation Parameters of a Nondepolarizing Optical-System from the Polar Decomposition of Its Mueller Matrix.” Optik 76(2): 67-71.Applicant
- Gladkova, N. D., G. A. Petrova, et al. (2000). “In vivo optical coherence tomography imaging of human skin: norm and pathology.” Skin Research and Technology 6 (1): 6-16.Applicant
- Glaessl, A., A. G. Schreyer, et al. (2001). “Laser surgical planning with magnetic resonance imaging-based 3-dimensional reconstructions for intralesional Nd : YAG laser therapy of a venous malformation of the neck.” Archives of Dermatology 137(10): 1331-1335.Applicant
- Gloesmann, M., B. Hermann, et al. (2003). “Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography.” Investigative Ophthalmoloqy & Visual Science 44(4): 1696-1703.Applicant
- Goldberg, L. and D. Mehuys (1994). “High-Power Superluminescent Diode Source.” Electronics Letters 30(20): 1682-1684.Applicant
- Goldsmith, J. A., Y. Li, et al. (2005). “Anterior chamber width measurement by high speed optical coherence tomography.” Ophthalmology 112(2): 238-244.Applicant
- Goldstein, L. E., J. A. Muffat, et al. (2003). “Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.” Lancet 361(9365): 1258-1265.Applicant
- Golubovic, B., B. E. Bouma, et al. (1996). “Thin crystal, room-temperature Cr/sup 4 +/:forstefite laser using near-infrared pumping.” Optics Letters 21(224): 1993-1995.Applicant
- Gonzalez, S. and Z. Tannous (2002). “Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma.” Journal of the American Academy of Dermatology 47(6): 869-874.Applicant
- Gordon, M. O. and M. A. Kass (1999). “The Ocular Hypertension Treatment Study: design and baseline description of the participants.” Archives of Ophthalmology 117(5): 573-83.Applicant
- Grayson, T. P., J. R. Torgerson, et al. (1994). “Observation of a Nonlocal Pancharatnam Phase-Shift in the Process of Induced Coherence without Induced Emission.” Physical Review A 49(1): 626-628.Applicant
- Greaney, M. J., D. C. Hoffman, et al. (2002). “Comparison of optic nerve imaging methods to distinguish normal eyes from those with glaucoma.” Investigative Ophthalmology & Visual Science 43(1): 140-5.Applicant
- Greenfield, D. S., H. Bagga, et al. (2003). “Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography.” Archives of Ophthalmology 121(1): 41-46.Applicant
- Greenfield, D. S., R. W. Knighton, et al. (2000). “Effect of corneal polarization axis on assessment of retinal nerve fiber layer thickness by scanning laser polarimetry.” American Journal of Ophthalmology 129(6): 715-722.Applicant
- Griffin, R. A., D. D. Sampson, et al. (1995). “Coherence Coding for Photonic Code-Division Multiple-Access Networks.” Journal of Lightwave Technology 13(9): 1826-1837.Applicant
- Guedes, V., J. S. Schuman, et al. (2003). “Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes.” Ophthalmology 110(1): 177-189.Applicant
- Gueugniaud, P. Y., H. Carsin, et al. (2000). “Current advances in the initial management of major thermal burns. [Review] [76 refs].” Intensive Care Medicine 26(7): 848-56.Applicant
- Guido, S. and R. T. Tranquillo (1993). “A Methodology for the Systematic and Quantitative Study of Cell Contact Guidance in Oriented Collagen Gels—Correlation of Fibroblast Orientation and Gel Birefringence.” Journal of Cell Science 105: 317-331.Applicant
- Gurses-Ozden, R., H. Ishikawa, et al. (1999). “Increasing sampling density improves reproducibility of optical coherence tomography measurements.” Journal of Glaucoma 8(4): 238-41.Applicant
- Guzzi, R. (1998). “Scattering Theory from Homogeneous and Coated Spheres.” 1-11.Applicant
- Haberland, U. B., Vladimir; Schmitt, Hans J. (1996). “Optical coherent tomography of scattering media using electrically tunable near-infrared semiconductor laser.” Applied Optics Draft.Applicant
- Haberland, U. R., Walter; Blazek, Vladimir; Schmitt, Hans J. (1995). “Investigation scattering media using near-infrared continuous wave tunable semiconductor laser.” Proc. SPIE , 2389: 503-512.Applicant
- Hale, G. M. and M. R. Querry (1973). “Optical-Constants of Water in 200-Nm to 200-Mum Wavelength Region.” Applied Optics 12(3): 555-563.Applicant
- Hammer, D. X., R. D. Ferguson, et al. (2002). “Image stabilization for scanning laser ophthalmoscopy.” Optics Express 10(26): 1542.Applicant
- Hara, T., Y. Ooi, et al. (1989). “Transfer Characteristics of the Microchannel Spatial Light-Modulator.” Applied Optics 28(22): 4781-4786.Applicant
- Harland, C. C., S. G. Kale, et al. (2000). “Differentiation of common benign pigmented skin lesions from melanoma by high-resolution ultrasound.” British Journal of Dermatology 143(2): 281-289.Applicant
- Hartl, I., X. D. Li, et al. (2001). “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber.” Optics Letters 26(9): 608-610.Applicant
- Hassenstein, A., A. A. Bialasiewicz, et al. (2000). “Optical coherence tomography in uveitis patients.” American Journal of Ophthalmology 130(5): 669-70.Applicant
- Hattenhauer, M. G., D. H. Johnson, et al. (1998). “The probability of blindness from open-angle glaucoma. [see comments].” Ophthalmology 105(11): 2099-104.Applicant
- Hausler, G., J. M. Herrmann, et al. (1996). “Observation of light propagation in volume scatterers with 10(11)-fold slow motion.” Optics Letters 21(14): 1087-1089.Applicant
- Hazebroek, H. F. and A. A. Holscher (1973). “Interferometric Ellipsometry.” Journal of Physics E-Scientific Instruments 6(9): 822-826.Applicant
- Hazebroek, H. F. and W. M. Visser (1983). “Automated Laser Interferometric Ellipsometry and Precision Reflectometry.” Journal of Physics E-Scientific Instruments 16(7): 654-661.Applicant
- He, Z. Y., N. Mukohzaka, et al. (1997). “Selective image extraction by synthesis of the coherence function using two-dimensional optical lock-in amplifier with microchannel spatial light modulator.” Ieee Photonics Technology Letters 9(4): 514-516.Applicant
- Hee, M. R., J. A. Izatt, et al. (1993). “Femtosecond Transillumination Optical Coherence Tomography.” Optics Letters 18(12): 950-952.Applicant
- Hee, M. R., J. A. Izatt, et al. (1995). “Optical coherence tomography of the human retina.” Archives of Ophthalmology 113(3): 325-32.Applicant
- Hee, M. R., C. A. Puliafito, et al. (1998). “Topography of diabetic macular edema with optical coherence tomography.” Ophthalmology 105(2): 360-70.Applicant
- Hee, M. R., C. A. Puliafito, et al. (1995). “Quantitative assessment of macular edema with optical coherence tomography.” Archives of Ophthalmology 113(8): 1019-29.Applicant
- Hellmuth, T. and M. Welle (1998). “Simultaneous measurement of dispersion, spectrum, and distance with a fourier transform spectrometer.” Journal of Biomedical Optics 3(1): 7-11.Applicant
- Hemenger, R. P. (1989). “Birefringence of a medium of tenuous parallel cylinders.” Applied Optics 28(18): 4030-4034.Applicant
- Henry, M. (1981). “Fresnel-Arago Laws for Interference in Polarized-Light—Demonstration Experiment.” American Journal of Physics 49(7): 690-691.Applicant
- Herz, P. R., Y. Chen, et al. (2004). “Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography.” Optics Letters 29(19): 2261-2263.Applicant
- Hirakawa, H., H. Iijima, et al. (1999). “Optical coherence tomography of cystoid macular edema associated with retinitis pigmentosa.” American Journal of Ophthalmology 128(2): 185-91.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1994). “Interferometric Measurement of Corneal Thickness with Micrometer Precision.” American Journal of Ophthalmology 118(4): 468-476.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1999). “Dispersion effects in partial coherence interferometry: Implications for intraocular ranging.” Journal of Biomedical Optics 4(1): 144-151.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1998). “Dispersion induced multiple signal peak splitting in partial coherence interferometry.” Optics Communications 154 (4): 179-185.Applicant
- Hitzenberger, C. K., M. Danner, et al. (1999). “Measurement of the spatial coherence of superluminescent diodes.” Journal of Modern Optics 46(12): 1763-1774.Applicant
- Hitzenberger, C. K. and A. F. Fercher “Differential phase contract in optical coherence tomography.” Optics Letters 24(9): 622-624.Applicant
- Hitzenberger, C. K., M. Sticker, et al. (2001). “Differential phase measurements in low-coherence interferometry without 2 pi ambiguity.” Optics Letters 26(23): 1864-1866.Applicant
- Hoeling, B. M., A. D. Fernandez, et al. (2000). “An optical coherence microscope for 3-dimensional imaging in developmental biology.” Optics Express 6(7): 136-146.Applicant
- Hoerauf, H., C. Scholz, et al. (2002). “Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye.” Archives of Ophthalmology 120(6): 816-9.Applicant
- Hoffmann, K., M. Happe, et al. (1998). “Optical coherence tomography (OCT) in dermatology.” Journal of Investigative Dermatology 110(4): 583-583.Applicant
- Hoh, S. T., D. S. Greenfield, et al. (2000). “Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes.” American Journal of Ophthalmology 129(2): 129-35.Applicant
- Hohenleutner, U., M. Hilbert, et al. (1995). “Epidermal Damage and Limited Coagulation Depth with the Flashlamp-Pumped Pulsed Dye-Laser—a Histochemical-Study.” Journal of Investigative Dermatology 104(5): 798-802.Applicant
- Holland, A. J. A., H. C. O. Martin, et al. (2002). “Laser Doppler imaging prediction of burn wound outcome in children.” Burns 28(1): 11-17.Applicant
- Hotate, K. and T. Okugawa (1994). “Optical Information-Processing by Synthesis of the Coherence Function.” Journal of Lightwave Technology 12(7): 1247-1255.Applicant
- Hourdakis, C. J. and A. Perris (1995). “A Monte-Carlo Estimation of Tissue Optical-Properties for Use in Laser Dosimetry.” Physics in Medicine and Biology 40(3): 351-364.Applicant
- Hu, Z., F. Li, et al. (2000). “Wavelength-tunable narrow-linewidth semiconductor fiber-ring laser.” IEEE Photonics Technology Letters 12(8): 977-979.Applicant
- Huang, F., W. Yang, et al. (2001). “Quadrature spectral interferometric detection and pulse shaping.” Optics Letters 26(6): 382-384.Applicant
- Huang, X. R. and R. W. Knighton (2002). “Linear birefringence of the retinal nerve fiber layer measured in vitro with a multispectral imaging micropolarimeter.” Journal of Biomedical Optics 7(2): 199-204.Applicant
- Huber, R., M. Wojtkowski, et al. (2005). “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles.” Optics Express 13(9): 3513-3528.Applicant
- Hunter, D. G., J. C. Sandruck, et al. (1999). “Mathematical modeling of retinal birefringence scanning.” Journal of the Optical Society of America a—Optics Image Science and Vision 16(9): 2103-2111.Applicant
- Hurwitz, H. H. and R. C. Jones (1941). “A new calculus for the treatment of optical systems II. Proof of three general equivalence theorems.” Journal of the Optical Society of America 31(7): 493-499.Applicant
- Huttner, B., C. De Barros, et al. (1999). “Polarization-induced pulse spreading in birefringent optical fibers with zero differential group delay.” Optics Letters 24(6): 370-372.Applicant
- Huttner, B., B. Gisin, et al. (1999). “Distributed PMD measurement with a polarization-OTDR in optical fibers.” Journal of Lightwave Technology 17(10): 1843-1848.Applicant
- Huttner, B., J. Reecht, et al. (1998). “Local birefringence measurements in single-mode fibers with coherent optical frequency-domain reflectometry.” Ieee Photonics Technology Letters 10(10): 1458-1460.Applicant
- Hyde, S. C. W., N. P. Barry, et al. (1995). “Sub-100-Mu-M Depth-Resolved Holographic Imaging through Scattering Media in the near-Infrared.” Optics Letters 20(22): 2330-2332.Applicant
- Hyde, S. C. W., N. P. Barry, et al. (1995). “Depth-Resolved Holographic Imaging through Scattering Media by Photorefraction.” Optics Letters 20(11): 1331-1333.Applicant
- Iftimia, N. V., B. E. Bouma, et al. (2004). “Adaptive ranging for optical coherence tomography.” Optics Express 12(17): 4025-4034.Applicant
- Iida, T., N. Hagimura, et al. (2000). “Evaluation of central serous chorioretinopathy with optical coherence tomography.” American Journal of Ophthalmology 129(1): 16-20.Applicant
- Imai, M., H. Iijima, et al. (2001). “Optical coherence tomography of tractional macular elevations in eyes with proliferative diabetic retinopathy. [republished in Am J Ophthalmol. Sep. 2001;132(3):458-61 ; 11530091.].” American Journal of Ophthalmology 132(1): 81-4.Applicant
- Indebetouw, G. and P. Klysubun (2000). “Imaging through scattering media with depth resolution by use of low-coherence gating in spatiotemporal digital holography.” Optics Letters 25(4): 212-214.Applicant
- Ip, M. S., B. J. Baker, et al. (2002). “Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography.” Archives of Ophthalmology 120(1): 29-35.Applicant
- Ismail, R., V. Tanner, et al. (2002). “Optical coherence tomography imaging of severe commotio retinae and associated macular hole.” British Journal of Ophthalmology 86(4): 473-4.Applicant
- Izatt, J. A., M. R. Hee, et al. (1994). “Optical Coherence Microscopy in Scattering Media.” Optics Letters 19(8): 590-592.Applicant
- Izatt, J. A., M. R. Hee, et al. (1994). “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography.” Archives of Ophthalmology 112 (12): 1584-9.Applicant
- Izatt, J. A., M. D. Kulkami, et al. (1997). “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography.” Optics Letters 22(18): 1439-1441.Applicant
- Izatt, J. A., M. D. Kulkarni, et al. (1996). “Optical coherence tomography and microscopy in gastrointestinal tissues.” IEEE Journal of Selected Topics in Quantum Electronics 2(4): 1017.Applicant
- Jacques, S. L., J. S. Nelson, et al. (1993). “Pulsed Photothermal Radiometry of Port-Wine-Stain Lesions.” Applied Optics 32(13): 2439-2446.Applicant
- Jacques, S. L., J. R. Roman, et al. (2000). “Imaging superficial tissues with polarized light.” Lasers in Surgery and Medicine 26(2): 119-129.Applicant
- Jang, I. K., B. E. Bouma, et al. (2002). “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound.” Journal of the American College of Cardiology 39(4): 604-609.Applicant
- Jang, I. K., B. D. MacNeill, et al. (2002). “In-vivo characterization of coronary plaques in patients with ST elevation acute myocardial infarction using optical coherence tomography (OCT).” Circulation 106(19): 698-698 3440 Suppl. S.,Applicant
- Jang, I. K., G. J. Tearney, et al. (2000). “Comparison of optical coherence tomography and intravascular ultrasound for detection of coronary plaques with large lipid-core in living patients.” Circulation 102(18): 509-509.Applicant
- Jeng, J. C., A. Bridgeman, et al. (2003). “Laser Doppler imaging determines need for excision and grafting in advance of clinical judgment: a prospective blinded trial.” Burns 29(7): 665-670.Applicant
- Jesser, C. A., S. A. Boppart, et al. (1999). “High resolution imaging of transitional cell carcinoma with optical coherence tomography: feasibility for the evaluation of bladder pathology.” British Journal of Radiology 72: 1170-1176.Applicant
- Johnson, C. A., J. L. Keltner, et al. (2002). “Baseline visual field characteristics in the ocular hypertension treatment study.” Ophthalmology 109(3): 432-7.Applicant
- Jones, R. C. (1941). “A new calculus for the treatment of optical systems III. The Sohncke theory of optical activity.” Journal of the Optical Society of America 31 (7): 500-503.Applicant
- Jones, R. C. (1941). “A new calculus for the treatment of optical systems I. Description and discussion of the calculus.” Journal of the Optical Society of America 31(7): 488-493.Applicant
- Jones, R. C. (1942). “A new calculus for the treatment of optical systems. IV.” Journal of the Optical Society of America 32(8): 486-493.Applicant
- Jones, R. C. (1947). “A New Calculus for the Treatment of Optical Systems .6. Experimental Determination of the Matrix.” Journal of the Optical Society of America 37(2): 110-112.Applicant
- Jones, R. C. (1947). “A New Calculus for the Treatment of Optical Systems .5. A More General Formulation, and Description of Another Calculus.” Journal of the Optical Society of America 37(2): 107-110.Applicant
- Jones, R. C. (1948). “A New Calculus for the Treatment of Optical Systems .7. Properties of the N-Matrices.” Journal of the Optical Society of America 38(8): 671-685.Applicant
- Jones, R. C. (1956). “New Calculus for the Treatment of Optical Systems .8. Electromagnetic Theory.” Journal of the Optical Society of America 46(2): 126-131.Applicant
- Jopson, R. M., L. E. Nelson, et al. (1999). “Measurement of second-order polarization-mode dispersion vectors in optical fibers.” Ieee Photonics Technology Letters II polarization-mode (9): 1153-1155.Applicant
- Jost, B. M., A. V. Sergienko, et al. (1998). “Spatial correlations of spontaneously down-converted photon pairs detected with a single-photon-sensitive CCD camera.” Optics Express 3(2): 81-88.Applicant
- Kaplan, B., E. Compain, et al. (2000). “Phase-modulated Mueller ellipsometry characterization of scattering by latex sphere suspensions.” Applied Optics 39 (4): 629-636.Applicant
- Kass, M. A., D. K. Heuer, et al. (2002). “The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.” Archives of Ophthalmology 120(6): 701-13; discussion 829-30.Applicant
- Kasuga, Y., J. Arai, et al. (2000). “Optical coherence tomograghy to confirm early closure of macular holes.” American Journal of Ophthalmology 130(5): 675-6.Applicant
- Kaufman, T., S. N. Lusthaus, et al. (1990). “Deep Partial Skin Thickness Burns—a Reproducible Animal-Model to Study Burn Wound-Healing.” Burns 16(1): 13-16.Applicant
- Kemp, N. J., J. Park, et al. (2005). “High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography.” Journal of the Optical Society of America a—Optics Image Science and Vision 22(3): 552-560.Applicant
- Kerrigan-Baumrind, L. A., H. A. Quigley, et al. (2000). “Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons.” Investigative Ophthalmology & Visual Science 41(3): 741-8.Applicant
- Kesen, M. R., G. L. Spaeth, et al. (2002). “The Heidelberg Retina Tomograph vs clinical impression in the diagnosis of glaucoma.” American Journal of Ophthalmology 133(5): 613-6.Applicant
- Kienle, A. and R. Hibst (1995). “A New Optimal Wavelength for Treatment of Port-Wine Stains.” Physics in Medicine and Biology 40(10): 1559-1576.Applicant
- Kienle, A., L. Lilge, et al. (1996). “Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue.” Applied Optics 35(13): 2304-2314.Applicant
- Kim, B. Y. and S. S. Choi (1981). “Analysis and Measurement of Birefringence in Single-Mode Fibers Using the Backscattering Method.” Optics Letters 6(11): 578-580.Applicant
- Kimel, S., L. O. Svaasand, et al. (1994). “Differential Vascular-Response to Laser Photothermolysis.” Journal of Investigative Dermatology 103(5): 693-700.Applicant
- Kloppenberg, F. W. H., G. Beerthuizen, et al. (2001). “Perfusion of burn wounds assessed by Laser Doppler Imaging is related to burn depth and healing time.” Burns 27(4): 359-363.Applicant
- Knighton, R. W. and X. R. Huang (2002). “Analytical methods for scanning laser polarimetry.” Optics Express 10(21): 1179-1189.Applicant
- Knighton, R. W., X. R. Huang, et al. (2002). “Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessment.” Investigative Ophthalmology & Visual Science 43(2): 383-392.Applicant
- Knuettel, A. R. S., Joseph M.: Shay, M.; Knutson, Jay R. (1994). “Stationary low-coherence light imaging and spectroscopy using a CCD camera.” Proc. SPIE , vol. 2135: p. 239-250.Applicant
- Knuttel, A. and M. Boehlau-Godau (2000). “Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography.” Journal of Biomedical Optics 5(1): 83-92.Applicant
- Knuttel, A. and J. M. Schmitt (1993). “Stationary Depth-Profiling Reflectometer Based on Low-Coherence Interferometry.” Optics Communications 102(3-4): 193-198.Applicant
- Knuttel, A., J. M. Schmitt, et al. (1994). “Low-Coherence Reflectometry for Stationary Lateral and Depth Profiling with Acoustooptic Deflectors and a Ccd Camera.” Optics Letters 19(4): 302-304.Applicant
- Kobayashi, M., H. Hanafusa, et al. (1991). “Polarization-Independent Interferometric Optical-Time-Domain Reflectometer.” Journal of Lightwave Technology 9(5): 623-628.Applicant
- Kolios, M. C., M. D. Sherar, et al. (1995). “Large Blood-Vessel Cooling in Heated Tissues—a Numerical Study.” Physics in Medicine and Biology 40(4): 477-494.Applicant
- Koozekanani, D., K. Boyer, et al. (2001). “Retinal thickness measurements from optical coherence tomography using a Markov boundary model.” Ieee Transactions on Medical Imaging 20(9): 900-916.Applicant
- Kop, R. H. J. and R. Sprik (1995). “Phase-sensitive interferometry with ultrashort optical pulses.” Review of Scientific Instruments 66(12): 5459-5463.Applicant
- Kramer, R. Z., J. Bella, et al. (1999). “Sequence dependent conformational variations of collagen triple-helical structure.” Nature Structural Biology 6(5): 454-7.Applicant
- Kulkarni, M. D., T. G. van Leeuwen, et al. (1998). “Velocity-estimation accuracy and frame-rate limitations in color Doppler optical coherence tomography.” Optics Letters 23(13): 1057-1059.Applicant
- Kwon, Y. H., C. S. Kim, et al. (2001). “Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma.” American Journal of Ophthalmology 132(1): 47-56.Applicant
- Kwong, K. F., D. Yankelevich, et al. (1993). “400-Hz Mechanical Scanning Optical Delay-Line.” Optics Letters 18(7): 558-560.Applicant
- Landers, J., I. Goldberg, et al. (2002). “Analysis of risk factors that may be associated with progression from ocular hypertension to primary open angle glaucoma.” Clin Experiment Ophthalmogy 30(4): 242-7.Applicant
- Laszlo, A. and A. Venetianer (1998). Heat resistance in mammalian cells: Lessons and challenges. Stress of Life. 851: 169-178.Applicant
- Laszlo, A. and A. Venetianer (1998). “Heat resistance in mammalian cells: lessons and challenges. [Review] [52 refs].” Annals of the New York Academy of Sciences 851: 169-78.Applicant
- Laufer, J., R. Simpson, et al. (1998). “Effect of temperature on the optical properties of ex vivo human dermis and subdermis.” Physics in Medicine and Biology 43(9): 2479-2489.Applicant
- Lederer, D. E., J. S. Schuman, et al. (2003). “Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography.” American Journal of Ophthalmology 135(6): 838-843.Applicant
- Lee, P. P., Z. W. Feldman, et al. (2003). “Longitudinal prevalence of major eye diseases.” Archives of Ophthalmology 121(9): 1303-1310.Applicant
- Lehrer, M. S., T. T. Sun, et al. (1998). “Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation.” Journal of Cell Science 111(Pt 19): 2867-75.Applicant
- Leibowitz, H. M., D. E. Krueger, et al. (1980). “The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975.” Survey of Ophthalmology 24(Suppl): 335-610.Applicant
- Leitgeb, R., C. K. Hitzenberger, et al. (2003). “Performance of fourier domain vs. time domain optical coherence tomography.” Optics Express 11(8): 889-894.Applicant
- Leitgeb, R., L. F. Schmetterer, et al. (2002). “Flow velocity measurements by frequency domain short coherence interferometry.” Proc. SPIE 4619: 16-21.Applicant
- Leitgeb, R. A., W. Drexler, et al. (2004). “Ultrahigh resolution Fourier domain optical coherence tomography.” Optics Express 12(10): 2156-2165.Applicant
- Leitgeb, R. A., C. K. Hitzenberger, et al. (2003). “Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography.” Optics Letters 28(22): 2201-2203.Applicant
- Leitgeb, R. A., L. Schmetterer, et al. (2003). “Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography.” Optics Express 11(23): 3116-3121.Applicant
- Leitgeb, R. A., L. Schmetterer, et al. (2004). “Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography.” Optics Letters 29 (2): 171-173.Applicant
- LeRoyBrehonnet, F. and B. LeJeune (1997). “Utilization of Mueller matrix formalism to obtain optical targets depolarization and polarization properties.” Progress in Quantum Electronics 21(2): 109-151.Applicant
- Leske, M. C., A. M. Connell, et al. (1995). “Risk factors for open-angle glaucoma. The Barbados Eye Study. [see comments].” Archives of Ophthalmology 113(7): 918-24.Applicant
- Leske, M. C., A. M. Connell, et al. (2001). “Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. [see comments].” Archives of Ophthalmology 119(1): 89-95.Applicant
- Leske, M. C., A. Heijl, et al. (1999). “Early Manifest Glaucoma Trial. Design and Baseline Data.” Ophthalmology 106(11): 2144-2153.Applicant
- Lewis, S. E., J. R. DeBoer, et al. (2005). “Sensitive, selective, and analytical improvements to a porous silicon gas sensor.” Sensors and Actuators B: Chemical 110(1): 54-65.Applicant
- Lexer, F., C. K. Hitzenberger, et al. (1999). “Dynamic coherent focus OCT with depth-independent transversal resolution.” Journal of Modern Optics 46(3): 541-553.Applicant
- Li, X., C. Chudoba, et al. (2000). “Imaging needle for optical coherence tomography.” Optics Letters 25: 1520-1522.Applicant
- Li, X., T. H. Ko, et al. (2001). “Intraluminal fiber-optic Doppler imaging catheter for structural and functional optical coherence tomography.” Optics Letters 26: 1906-1908.Applicant
- Liddington, M. I. and P. G. Shakespeare (1996). “Timing of the thermographic assessment of burns.” Burns 22(1): 26-8.Applicant
- Lindmo, T., D. J. Smithies, et al. (1998). “Accuracy and noise in optical Doppler tomography studied by Monte Carlo simulation.” Physics in Medicine and Biology 43(10): 3045-3064.Applicant
- Liu, J., X. Chen, et al. (1999). “New thermal wave aspects on burn evaluation of skin subjected to instantaneous heating.” IEEE Transactions on Biomedical Engineering 46(4): 420-8.Applicant
- Luke, D. G., R. McBride, et al. (1995). “Polarization mode dispersion minimization in fiber-wound piezoelectric cylinders.” Optics Letters 20(24): 2550-2552.Applicant
- MacNeill, B. D., I. K. Jang, et al. (2004). “Focal and multi-focal plaque distributions in patients with macrophage acute and stable presentations of coronary artery disease.” Journal of the American College of Cardiology 44(5): 972-979.Applicant
- Mahgerefteh, D. and C. R. Menyuk (1999). “Effect of first-order PMD compensation on the statistics of pulse broadening in a fiber with randomly varying birefringence.” Ieee Photonics Technology Letters 11(3): 340-342.Applicant
- Maitland, D. J. and J. T. Walsh, Jr. (1997). “Quantitative measurements of linear birefringence during heating of native collagen.” Lasers in Surgery & Medicine 20 (3): 310-8.Applicant
- Majaron, B., S. M. Srinivas, et al. (2000). “Deep coagulation of dermal collagen with repetitive Er : YAG laser irradiation.” Lasers in Surgery and Medicine 26(2): 215-222.Applicant
- Mansuripur, M. (1991). “Effects of High-Numerical-Aperture Focusing on the State of Polarization in Optical and Magnetooptic Data-Storage Systems.” Applied Optics 30(22): 3154-3162.Applicant
- Marshall, G. W., S. J. Marshall, et al. (1997). “The dentin substrate: structure and properties related to bonding.” Journal of Dentistry 25(6): 441-458.Applicant
- Martin, P. (1997). “Wound healing—Aiming for perfect skin regeneration.” Science 276 (5309): 75-81.Applicant
- Martinez, O. E. (1987). “3000 Times Grating Compressor with Positive Group-Velocity Dispersion—Application to Fiber Compensation in 1.3-1.6 Mu-M Region.” Ieee Journal of Quantum Electronics 23(1): 59-64.Applicant
- Martinez, O. E., J. P. Gordon, et al. (1984). “Negative Group-Velocity Dispersion Using Refraction.” Journal of the Optical Society of America a—Optics Image Science and Vision 1(10): 1003-1006.Applicant
- McKinney, J. D., M. A. Webster, et al. (2000). “Characterization and imaging in optically scattering media by use of laser speckle and a variable-coherence source.” Optics Letters 25(1): 4-6.Applicant
- Miglior, S., M. Casula, et al. (2001). “Clinical ability of heidelberg retinal tomograph examination to detect glaucomatous visual field changes.” Ophthalmology 108 (9): 1621-7.Applicant
- Milner, T. E., D. M. Goodman, et al. (1996). “Imaging laser heated subsurface chromophores in biological materials: Determination of lateral physical dimensions.” Physics in Medicine and Biology 41(1): 31-44.Applicant
- Milner, T. E., D. M. Goodman, et al. (1995). “Depth Profiling of Laser-Heated Chromophores in Biological Tissues by Pulsed Photothermal Radiometry.” Journal of the Optical Society of America a—Optics Image Science and Vision 12 (7): 1479-1488.Applicant
- Milner, T. E., D. J. Smithies, et al. (1996). “Depth determination of chromophores in human skin by pulsed photothermal radiometry.” Applied Optics 35(19): 3379-3385.Applicant
- Mishchenko, M. I. and J. W. Hovenier (1995). “Depolarization of Light Backscattered by Randomly Oriented Nonspherical Particles.” Optics Letters 20(12): 1356-&.Applicant
- Mistlberger, A., J. M. Liebmann, et al. (1999). “Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes.” Ophthalmology 106(10): 2027-32.Applicant
- Mitsui, T. (1999). “High-speed detection of ballistic photons propagating through suspensions using spectral interferometry.” Japanese Journal of Applied Physics Part 1—Regular Papers Short Notes & Review Papers 38(5A): 2978-2982.Applicant
- Molteno, A. C., N. J. Bosma, et al. (1999). “Otago glaucoma surgery outcome study: long-term results of trabeculectomy—1976 to 1995.” Ophthalmology 106(9): 1742-50.Applicant
- Morgner, U., W. Drexler, et al. (2000). “Spectroscopic optical coherence tomography.” Optics Letters 25(2): 111-113.Applicant
- Morgner, U., F. X. Kartner, et al. (1999). “Sub-two-cycle pulses from a Kerr-lens mode-locked Ti : sapphire laser (vol. 24, p. 411, 1999).” Optics Letters 24(13): 920-920.Applicant
- Mourant, J. R., A. H. Hielscher, et al. (1998). “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells.” Cancer Cytopathology 84(6): 366-374.Applicant
- Muller, M., J. Squier, et al. (1998). “Dispersion pre-compensation of 15 femtosecond optical pulses for high-numerical-aperture objectives.” Journal of Microscopy-Oxford 191: 141-150.Applicant
- Muscat, S., N. McKay, et al. (2002). “Repeatability and reproducibility of corneal thickness measurements by optical coherence tomography.” Investigative Ophthalmology & Visual Science 43(6): 1791-5.Applicant
- Musch, D. C., P. R. Lichter, et al. (1999). “The Collaborative Initial Glaucoma Treatment Study. Study Design, Methods, and Baseline Characteristics of Enrolled Patients.” Ophthalmology 106: 653-662.Applicant
- Neerken, S., Lucassen, G.W., Bisschop, M.A., Lenderink, E., Nuijs, T.A.M. (2004). “Characterization of age-related effects in human skin: A comparative study that applies confocal laser scanning microscopy and optical coherence tomography.” Journal of Biomedical Optics 9(2): 274-281.Applicant
- Nelson, J. S., K. M. Kelly, et al. (2001). “Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography.” Archives of Dermatology 137(6): 741-744.Applicant
- Newson, T. P., F. Farahi, et al. (1988). “Combined Interferometric and Polarimetric Fiber Optic Temperature Sensor with a Short Coherence Length Source.” Optics Communications 68(3): 161-165.Applicant
- November, L. J. (1993). “Recovery of the Matrix Operators in the Similarity and Congruency Transformations—Applications in Polarimetry.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(4): 719-739.Applicant
- Oh, W. Y., S. H. Yun, et al. (2005). “Wide tuning range wavelength-swept laser with two semiconductor optical amplifiers.” Ieee Photonics Technology Letters 17(3): 678-680.Applicant
- Oka, K. and T. Kato (1999). “Spectroscopic polarimetry with a channeled spectrum.” Optics Letters 24(21): 1475-1477.Applicant
- Okugawa, T. and K. Rotate (1996). “Real-time optical image processing by synthesis of the coherence function using real-time holography.” IEEE Photonics Technology Letters 8(2): 257-259.Applicant
- Oshima, M., R. Torii, et al. (2001). “Finite element simulation of blood flow in the cerebral artery.” Computer Methods in Applied Mechanics and Engineering 191 (6-7): 661-671.Applicant
- Pan, Y. T., H. K. Xie, et al. (2001). “Endoscopic optical coherence tomography based on a microelectromechanical mirror.” Optics Letters 26(24): 1966-1968.Applicant
- Parisi, V., G. Manni, et al. (2001). “Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients.” Ophthalmology 108(5): 905-12.Applicant
- Park, B. H., M. C. Pierce, et al. (2005). “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 mu m.” Optics Express 13(11): 3931-3944.Applicant
- Park, D. H., J. W. Hwang, et al. (1998). “Use of laser Doppler flowmetry for estimation of the depth of burns.” Plastic and Reconstructive Surgery 101(6): 1516-1523.Applicant
- Pendry, J. B., A. J. Holden, et al. (1999). “Magnetism from conductors and enhanced nonlinear phenomena.” Ieee Transactions on Microwave Theory and Techniques 47(11): 2075-2084.Applicant
- Penninckx, D. and V. Morenas (1999). “Jones matrix of polarization mode dispersion.” Optics Letters 24(13): 875-877.Applicant
- Pierce, M. C., M. Shishkov, et al. (2005). “Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography.” Optics Express 13(15): 5739-5749.Applicant
- Pircher, M., E. Gotzinger, et al. (2003). “Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography.” Optics Express 11(18): 2190-2197.Applicant
- Pircher, M., E. Gotzinger, et al. (2003). “Speckle reduction in optical coherence tomography by frequency compounding.” Journal of Biomedical Optics 8(3): 565-569.Applicant
- Podoleanu, A. G., G. M. Dobre, et al. (1998). “En-face coherence imaging using galvanometer scanner modulation.” Optics Letters 23(3): 147-149.Applicant
- Podoleanu, A. G. and D. A. Jackson (1999). “Noise analysis of a combined optical coherence tomograph and a confocal scanning ophthalmoscope.” Applied Optics 38(10): 2116-2127.Applicant
- Podoleanu, A. G., J. A. Rogers, et al. (2000). “Three dimensional OCT images from retina and skin.” Optics Express 7(9): 292-298.Applicant
- Podoleanu, A. G., M. Seeger, et al. (1998). “Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry.” Journal of Biomedical Optics 3(1): 12-20.Applicant
- Poole, C. D. (1988). “Statistical Treatment of Polarization Dispersion in Single-Mode Fiber.” Optics Express Letters 13(8): 687-689.Applicant
- Povazay, B., K. Bizheva, et al. (2002). “Submicrometer axial resolution optical coherence tomography.” Optics Letters 27(20): 1800-1802.Applicant
- Qi, B., A. P. Himmer, et al. (2004). “Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror.” Optics Communications 232(1-6): 123-128.Applicant
- Radhakrishnan, S., A. M. Rollins, et al. (2001). “Real-time optical coherence tomography of the anterior segment at 1310 nm.” Archives of Ophthalmology 119(8): 1179-1185.Applicant
- Rogers, A. J. (1981). “Polarization-Optical Time Domain Reflectometry—a Technique for the Measurement of Field Distributions.” Applied Optics 20(6): 1060-1074.Applicant
- Rollins, A. M. and J. A. Izatt (1999). “Optimal interferometer designs for optical coherence tomography.” Optics Letters 24(21): 1484-1486.Applicant
- Rollins, A. M., R. Ung-arunyawee, et al. (1999). “Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design.” Optics Letters 24(19): 1358-1360.Applicant
- Rollins, A. M., S. Yazdanfar, et al. (2002). “Real-time in vivo colors Doppler optical coherence tomography.” Journal of Biomedical Optics 7(1): 123-129.Applicant
- Rollins, A. M., S. Yazdanfar, et al. (2000). “Imaging of human retinal hemodynamics using color Doppler optical coherence tomography.” Investigative Ophthalmology & Visual Science 41(4): S548-S548.Applicant
- Sandoz, P. (1997). “Wavelet transform as a processing tool in white-light interferometry.” Optics Letters 22(14): 1065-1067.Applicant
- Sankaran, V., M. J. Everett, et al. (1999). “Comparison of polarized-light propagation in biological tissue and phantoms.” Optics Letters 24(15): 1044-1046.Applicant
- Sankaran, V., J. T. Walsh, et al. (2000). “Polarized light propagation through tissue phanto, ehms containing densely packed scatterers.” Optics Letters 25(4): 239-241.Applicant
- Sarunic, M. V., M. A. Choma, et al. (2005). “Instantaneous complex conjugate resolved spectral domain and swept-source OCT using 3×3 fiber couplers.” Optics Express 13(3): 957-967.Applicant
- Sathyam, U. S., B. W. Colston, et al. (1999). “Evaluation of optical coherence quantitation of analytes in turbid media by use of two wavelengths.” Applied Optics 38(10): 2097-2104.Applicant
- Schmitt, J. M. (1997). “Array detection for speckle reduction in optical coherence microscopy.” Physics in Medicine and Biology 42(7): 1427-1439.Applicant
- Schmitt, J. M. (1999). “Optical coherence tomography (OCT): A review.” Ieee Journal of Selected Topics in Quantum Electronics 5(4): 1205-1215.Applicant
- Schmitt, J. M. and A. Knuttel (1997). “Model of optical coherence tomography of heterogeneous tissue.” Journal of the Optical Society of America a—Optics Image Science and Vision 14(6): 1231-1242.Applicant
- Schmitt, J. M., S. L. Lee, et al. (1997). “An optical coherence microscope with enhanced resolving power in thick tissue.” Optics Communications 142(4-6): 203-207.Applicant
- Schmitt, J. M., S. H. Xiang, et al. (1998). “Differential absorption imaging with optical coherence tomography.” Journal of the Optical Society of America a-Optics Image Science and Vision 15(9): 2288-2296.Applicant
- Schmitt, J. M., S. H. Xiang, et aI. (1999). “Speckle in optical coherence tomography.” Journal of Biomedical Optics 4(1): 95-105.Applicant
- Schmitt, J. M., M. J. Yadlowsky, et al. (1995). “Subsurface Imaging of Living Skin with Optical Coherence Microscopy.” Dermatology 191(2): 93-98.Applicant
- Shi, H., J. Finlay, et al. (1997). “Multiwavelength 10-GHz picosecond pulse generation from a single-stripe semiconductor diode laser.” Ieee Photonics Technology Letters 9(11): 1439-1441.Applicant
- Shi, H., I. Nitta, et al. (1999). “Demonstration of phase correlation in multiwavelength mode-locked semiconductor diode lasers.” Optics Letters 24(4): 238-240.Applicant
- Simon, R. (1982). “The Connection between Mueller and Jones Matrices of Polarization Optics.” Optics Communications 42(5): 293-297.Applicant
- Smith, P. J. M., E.M.; Taylor, C.M.; Selviah, D.R.; Day, S.E.; Commander, L.G. “Variable-Focus Microlenses as a Potential Technology for Endoscopy.”Applicant
- Smithies, D. J., T. Lindmo, et al. (1998). “Signal attenuation and localization in optical coherence tomography studied by Monte Carlo simulation.” Physics in Medicine and Biology 43(10): 3025-3044.Applicant
- Sorin, W. V. and D. F. Gray (1992). “Simultaneous Thickness and Group Index Measurement Using Optical Low-Coherence Reflectometry.” Ieee Photonics Technology Letters 4(1): 105-107.Applicant
- Sticker, M., C. K. Hitzenberger, et al. (2001). “Quantitative differential phase measurement and imaging in transparent and turbid media by optical coherence tomography.” Optics Letters 26(8): 518-520.Applicant
- Sticker, M., M. Pircher, et al. (2002). “En face imaging of single cell layers by differential phase-contrast optical coherence microscopy.” Optics Letters 27(13): 1126-1128.Applicant
- Stoller, P., B. M. Kim, et al. (2002). “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon.” Journal of Biomedical Optics 7(2): 205-214.Applicant
- Sun, C. S. (2003). “Multiplexing of fiber-optic acoustic sensors in a Michelson interferometer configuration.” Optics Letters 28(12): 1001-1003.Applicant
- Swanson, E. A., J. A. Izatt, et al. (1993). “In-Vivo Retinal Imaging by Optical Coherence Tomography.” Optics Letters 18(21): 1864-1866.Applicant
- Takada, K., A. Himeno, et al. (1991). “Phase-Noise and Shot-Noise Limited Operations of Low Coherence Optical-Time Domain Reflectometry.” Applied Physics Letters 59(20): 2483-2485.Applicant
- Takenaka, H. (1973). “Unified Formalism for Polarization Optics by Using Group-Theory I (Theory).” Japanese Journal of Applied Physics 12(2): 226-231.Applicant
- Tanno, N., T. Ichimura, et al. (1994). “Optical Multimode Frequency-Domain Reflectometer.” Optics Letters 19(8): 587-589.Applicant
- Tan-no, N., T. Ichimura, et al. (1994). “Optical Multimode Frequency-Domain Reflectometer.” Optics Letters 19(8): 587-589.Applicant
- Targowski, P., M. Wojtkowski, et al. (2004). “Complex spectral OCT in human eye imaging in vivo.” Optics Communications 229(1-6): 79-84.Applicant
- Tearney, G. J., S. A. Boppart, et al. (1996). “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography (vol. 21, p. 543, 1996).” Optics Letters 21(12): 912-912.Applicant
- Tearney, G. J., B. E. Bouma, et al. (1996). “Rapid acquisition of in vivo biological images by use of optical coherence tomography.” Optics Letters 21(17): 1408-1410.Applicant
- Tearney, G. J., B. E. Bouma, et al. (1997). “In vivo endoscopic optical biopsy with optical coherence tomography.” Science 276(5321): 2037-2039.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1996). “Catheter-based optical imaging of a human coronary artery.” Circulation 94(11): 3013-3013.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1997). “In vivo endoscopic optical biopsy with optical coherence tomography.” Science 276(5321): 2037-9.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1997). “Optical biopsy in human gastrointestinal tissue using optical coherence tomography.” American Journal of Gastroenterology 92(10): 1800-1804.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1995). “Determination of the refractie index of highly scattering human tissue by optical coherence tomography.” Optics Letters 20(21): 2258-2260.Applicant
- Tearney, G. J., I. K. Jang, et al. (2000). “Porcine coronary imaging in vivo by optical coherence tomography.” Acta Cardiologica 55(4): 233-237.Applicant
- Tearney, G. J., R. H. Webb, et al. (1998). “Spectrally encoded confocal microscopy.” Optics Letters 23(15): 1152-1154.Applicant
- Tearney, G. J., H. Yabushita, et al. (2003). “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography.” Circulation 107(1): 113-119.Applicant
- Tower, T. T. and R. T. Tranquillo (2001). “Alignment maps of tissues: I. Microscopic elliptical polarimetry.” Biophysical Journal 81(5): 2954-2963.Applicant
- Tower, T. T. and R. T. Tranquillo (2001). “alignment maps of tissues: II. Fast harmonic analysis for imaging.” Biophysical Journal 81(5): 2964-2971.Applicant
- Troy, T. L. and S. N. Thennadil (2001). “Optical properties of human skin in the near infrared wavelength range of 1000 to 2200 nm.” Journal of Biomedical Optics 6 (2): 167-176.Applicant
- Vabre, L., A. Dubois, et al. (2002). “Thermal-light full-field optical coherence tomography.” Optics Letters 27(7): 530-532.Applicant
- Vakhtin, A. B., D. J. Kane, et al. (2003). “Common-path interferometer for frequency-domain optical coherence tomography.” Applied Optics 42(34): 6953-6958.Applicant
- Vakhtin, A. B., K. A. Peterson, et al. (2003). “Differential spectral interferometry: an imaging technique for biomedical applications.” Optics Letters 28(15): 1332-1334.Applicant
- Vakoc, B. J., S. H. Yun, et al. (2005). “Phase-resolved optical frequency domain imaging.” Optics Express 13(14): 5483-5493.Applicant
- Van Leeuwen, T. G., M. D. Kulkarni, et al. (1999). “High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography.” Optics Letters 24(22): 1584-1586.Applicant
- Vansteenkiste, N., P. Vignolo, et al. (1993). “Optical Reversibility Theorems for Polarization—Application to Remote-Control of Polarization.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(10): 2240-2245.Applicant
- Vargas, O., E. K. Chan, et al. (1999). “Use of an agent to reduce scattering in skin.” Lasers in Surgery and Medicine 24(2): 133-141.Applicant
- Wang, R. K. (1999). “Resolution improved optical coherence-gated tomography for imaging through biological tissues.” Journal of Modern Optics 46(13): 1905-1912.Applicant
- Wang, X. J., T. E. Milner, et al. (1997). “Measurement of fluid-flow-velocity profile in turbid media by the use of optical Doppler tomography.” Applied Optics 36(1): 144-149.Applicant
- Wang, X. J., T. E. Milner, et al. (1995). “Characterization of Fluid-Flow Velocity by Optical Doppler Tomography.” Optics Letters 20(11): 1337-1339.Applicant
- Wang, Y. M., J. S. Nelson, et al. (2003). “Optimal wavelength for ultrahigh-resolution optical coherence tomography.” Optics Express 11(12): 1411-1417.Applicant
- Wang, Y. M., Y. H. Zhao, et al. (2003). “Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber.” Optics Letters 28(3): 182-184.Applicant
- Watkins, L. R., S. M. Tan, et al. (1999). “Determination of interferometer phase distributions by use of wavelets.” Optics Letters 24(13): 905-907.Applicant
- Wetzel, J. (2001). “Optical coherence tomography in dermatology: a review.” Skin Research and Technology 7(1): 1-9.Applicant
- Wentworth, R. H. (1989). “Theoretical Noise Performance of Coherence-Multiplexed Interferometric Sensors.” Journal of Lightwave Technology 7(6): 941-956.Applicant
- Westphal, V., A. M. Rollins, et al. (2002). “Correction of geometric and refractive image distortions in optical coherence tomography applying Fermat's principle.” Optics Express 10(9): 397-404.Applicant
- Westphal, V., S. Yazdanfar, et al. (2002). “Real-time, high velocity-resolution color Doppler optical coherence tomography.” Optics Letters 27(1): 34-36.Applicant
- Williams, P. A. (1999). “Rotating-wave-plate Stokes polarimeter for differential group delay measurements of polarization-mode dispersion.” Applied Optics 38(31): 6508-6515.Applicant
- Wojtkowski, M., T. Bajraszewski, et al. (2003). “Real-time in vivo imaging by high-speed spectral optical coherence tomography.” Optics Letters 28(19): 1745-1747.Applicant
- Wojtkowski, M., A. Kowalczyk, et al. (2002). “Full range complex spectral optical coherence tomography technique in eye imaging.”Optics Letters 27(16): 1415-1417.Applicant
- Wojtkowski, M., R. Leitgeb, et al. (2002). “In vivo human retinal imaging by Fourier domain optical coherence tomography.” Journal of Biomedical Optics 7(3): 457-463.Applicant
- Wojtkowski, M., R. Leitgeb, et al. (2002). “Fourier domain OCT imaging of the human eye in vivo.” Proc. SPIE 4619: 230-236.Applicant
- Wojtkowski, M., V. J. Srinivasan, et al. (2004). “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.” Optics Express 12(11): 2404-2422.Applicant
- Wong, B. J. F., Y. H. Zhao, et al. (2004). “Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 mu m and 1.3 mu m.” Otolaryngology—Head and Neck Surgery 130(3): 334-338.Applicant
- Yabushita, H. B., B.E.; Houser, S.L.; Aretz, H.T.; Jang, I.; Schlendorf, K.H.; Kauffman, C.R.; Shishkov, M.; Halpern, E.F.; Tearney, G.J. “Measurement of Thin Fibrous Caps in Atherosclerotic Plaques by Optical Coherence Tomography.”Applicant
- Yang, C., A. Wax, et al. (2001). “Phase-dispersion optical tomography.” Optics Letters 26(10): 686-688.Applicant
- Yang, C., A. Wax, et al. (2001). “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics.” Optics Letters 26(16): 1271-1273.Applicant
- Yang, C. H., A. Wax, et al. (2001). “Phase-dispersion optical tomography.” Optics Letters 26(10): 686-688.Applicant
- Yang, C. H., A. Wax, et al. (2000). “Interferometric phase-dispersion microscopy.” Optics Letters 25(20): 1526-1528.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2002). “Improved phase-resolved optical Doppler tomography using the Kasai velocity estimator and histogram segmentation.” Optics Communications 208(4-6): 209-214.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance.” Optics Express 11(7): 794-809.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis.” Optics Express 11(14): 1650-1658.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts.” Optics Express 11(19): 2416-2424.Applicant
- Yang, V. X. D., B. Qi, et al. (2003). “In vivo feasibility of endoscopic catheter-based Doppler optical coherence tomography.” Gastroenterology 124(4): A49-A50.Applicant
- Yao, G. and L. H. V. Wang (2000). “Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue.” Applied Optics 39(4): 659-664.Applicant
- Yazdanfar, S. and J. A. Izatt (2002). “Self-referenced Doppler optical coherence tomography.” Optics Letters 27(23): 2085-2087.Applicant
- Yazdanfar, S., M. D. Kulkarni, et al. (1997). “High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography.” Optics Express 1 (13) : 424-431.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2000). “Imaging and velocimetry of the human retinal circulation with color Doppler optical coherence tomography.” Optics Letters 25(19): 1448-1450.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2000). “Noninvasive imaging and velocimetry of human retinal blood flow using color Doppler optical coherence tomography.” Investigative Ophthalmology & Visual Science 41(4): S548-S548.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2003). “In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.” Archives of Ophthalmoloqy 121(2): 235-239.Applicant
- Yazdanfar, S., C. H. Yang, et al. (2005). “Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound.” Optics Express 13(2): 410-416.Applicant
- Yun, S. H., C. Boudoux, et al. (2004). “Extended-cavity semiconductor wavelength-swept laser for biomedical imaging.” Ieee Photonics Technology Letters 16(1): 293-295.Applicant
- Yun, S. H., C. Boudoux, et al. (2003). “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter.” Optics Letters 28(20): 1981-1983.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts.” Optics Express 12(23): 5614-5624.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting.” Optics Express 12(20): 4822-4828.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Motion artifacts in optical coherence tomography with frequency-domain ranging.” Optics Express 12(13): 2977-2998.Applicant
- Zhang, J., J. S. Nelson, et al. (2005). “Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator.” Optics Letters 30(2): 147-149.Applicant
- Zhang, Y., M. Sato, et al. (2001). “Numerical investigations of optimal synthesis of several low coherence sources for resolution improvement.” Optics Communications 192(3-6): 183-192.Applicant
- Zhang, Y., M. Sato, et al. (2001). “Resolution improvement in optical coherence tomography by optimal synthesis of light-emitting diodes.” Optics Letters 26(4): 205-207.Applicant
- Zhao, Y., Z. Chen, et al. (2002). “Real-time phase-resolved functional optical coherence tomography by use of optical Hilbert transformation.” Optics Letters 27(2): 98-100.Applicant
- Zhao, Y. H., Z. P. Chen, et al. (2000). “Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow.” Optics Letters 25(18): 1358-1360.Applicant
- Zhao, Y. H., Z. P. Chen, et al. (2000). “Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity.” Optics Letters 25(2): 114-116.Applicant
- Zhou, D., P. R. Prucnal, et al. (1998). “A widely tunable narrow linewidth semiconductor fiber ring laser.” IEEE Photonics Technology Letters 10(6): 781-783.Applicant
- Zuluaga, A. F. and R. Richards-Kortum (1999). “Spatially resolved spectral interferometry for determination of subsurface structure.” Optics Letters 24(8): 519-521.Applicant
- Zvyagin, A. V., J. B. FitzGerald, et al. (2000). “Real-time detection technique for Doppler optical coherence tomography.” Optics Letters 25(22): 1645-1647.Applicant
- Marc Nikles et al., “Brillouin gain spectrum characterization in single-mode optical fibers”, Journal of Lightwave Technology 1997, 15 (10): 1842-1851.Applicant
- Tsuyoshi Sonehara et al., “Forced Brillouin Spectroscopy Using Frequency-Tunable Continuous-Wave Lasers”, Physical Review Letters 1995, 75 (23): 4234-4237.Applicant
- Hajime Tanaka et al., “New Method of Superheterodyne Light Beating Spectroscopy for Brillouin-Scattering Using Frequency-Tunable Lasers” Physical Review Letters 1995, 74 (9): 1609-1612.Applicant
- Webb RH et al. “Confocal Scanning Laser Ophthalmoscope”, Applied Optics 1987, 26 (8): 1492-1499.Applicant
- Andreas Zumbusch et al. “Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering”, Physical Review Letters 1999, 82 (20): 4142-4145.Applicant
- Katrin Kneipp et al., “Single molecule detection using surface-enhanced Raman scattering (SERS)”, Physical Review Letters 1997, 78 (9): 1667-1670.Applicant
- K.J. Koski et al., “Brillouin imaging” Applied Physics Letters 87, 2005.Applicant
- Boas et al., “Diffusing temporal light correlation for burn diagnosis”, SPIE, 1999, 2979:468-477.Applicant
- David J. Briers, “Speckle fluctuations and biomedical optics: implications and applications”, Optical Engineering, 1993, 32(2):277-283.Applicant
- Clark et al., “Tracking Speckle Patterns with Optical Correlation”, SPIE, 1992, 1772:77-87.Applicant
- Facchini et al., “An endoscopic system for DSPI”, Optik, 1993, 95(1):27-30.Applicant
- Hrabovsky, M., “Theory of speckle dispacement and decorrelation: application in mechanics”, SPIE, 1998, 3479:345-354.Applicant
- Sean J. Kirkpatrick et al., “Micromechanical behavior of cortical bone as inferred from laser speckle data”, Journal of Biomedical Materials Research, 1998, 39(3):373-379.Applicant
- Sean J. Kirkpatrick et al., “Laser speckle microstrain measurements in vascular tissue”, SPIE, 1999, 3598:121-129.Applicant
- Loree et al., “Mechanical Properties of Model Atherosclerotic Lesion Lipid Pools”, Atheriosclerosis and Thrombosis, 1994, 14(2):230-234.Applicant
- Podbielska, H. “Interferometric Methods and Biomedical Research”, SPIE, 1999, 2732:134-141.Applicant
- Richards-Kortum et al., “Spectral diagnosis of atherosclerosis using an optical fiber laser catheter”, American Heart Journal, 1989, 118(2):381-391.Applicant
- Ruth, B. “blood flow determination by the laser speckle method”, Int J Microcirc: Clin Exp, 1990, 9:21-45.Applicant
- Shapo et al., “Intravascular strain imaging: Experiments on an Inhomogeneous Phantom”, IEEE Ultrasonics Symposium 1996, 2:1177-1180.Applicant
- Shapo et al., “Ultrasonic displacement and strain imaging of coronary arteries with a catheter array”, IEEE Ultrasonics Symposium 1995, 2:1511-1514.Applicant
- Thompson et al., “Imaging in scattering media by use of laser speckle”, Opt. Soc. Am. A., 1997, 14(9):2269-2277.Applicant
- Thompson et al., “Diffusive media characterization with laser speckle”, Applied Optics, 1997, 36(16):3726-3734.Applicant
- Tuchin, Valery V., “Coherent Optical Techniques for the Analysis of Tissue Structure and Dynamics,” Journal of Biomedical Optics, 1999, 4(1):106-124.Applicant
- M. Wussling et al., “Laser diffraction and speckling studies in skeletal and heart muscle”, Biomed, Biochim, Acta, 1986, 45(1/2):S 23-S 27.Applicant
- T. Yoshimura et al., “Statistical properties of dynamic speckles”, J. Opt. Soc. Am A. 1986, 3(7):1032-1054.Applicant
- Zimnyakov et al., “Spatial speckle correlometry in applications to tissue structure monitoring”, Applied Optics 1997, 36(22): 5594-5607.Applicant
- Zimnyakov et al., “A study of statistical properties of partially developed speckle fields as applied to the diagnosis of structural changes in human skin”, Optics and Spectroscopy, 1994, 76(5): 747-753.Applicant
- Zimnyakov et al., “Speckle patterns polarization analysis as an approach to turbid tissue structure monitoring”, SPIE 1999, 2981:172-180.Applicant
- Ramasamy Manoharan et al., “Biochemical analysis and mapping of atherosclerotic human artery using FT-IR microspectroscopy”, Atherosclerosis, May 1993, 181-1930.Applicant
- N.V. Salunke et al., “Biomechanics of Atherosclerotic Plaque” Critical Reviews™ in Biomedical Engineering 1997, 25(3):243-285.Applicant
- D. Fu et al., “Non-invasive quantitative reconstruction of tissue elasticity using an iterative forward approach”, Phys. Med. Biol. 2000 (45): 1495-1509.Applicant
- S.B. Adams Jr. et al., “The use of polarization sensitive optical coherence tomography and elastography to assess connective tissue”, Optical Soc. of American Washington 2002, p. 3.Applicant
- International Search Report for International Patent application No. PCT/US2005/039740.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/039740.Applicant
- International Search Report for International Patent application No. PCT/US2005/030294.Applicant
- “High Resolution in Vivo Intra-Arterial Imaging with Optical Coherence Tomography” by Jujimoto et al., in the Official Journal of the British Cardiac Society, vol. 82, pp. 128-133 Heart—1999.Applicant
- “Optical Coherence Tomography” by D. Huang et al., in Science, vol. 254, pp. 1178-1181, Nov. 1991.Applicant
- “High-Speed Phase—and Group Delay Scanning with a Grating Based Phase Control Delay Line” by Tearney, et al., in Optics Letters, vol. 22, pp. 1811-1813, Dec. 1997.Applicant
- “In Vivo Video Rate Optical Coherence Tomography” by Rollins, et al., in the Optics Express, vol. 3, pp. 219-229, Sep. 1998.Applicant
- High Speed Fiber-Based Polarization-Sensitive Optical Coherence Tomography of in Vivo Human Skin by Saxer, et al., in the Optical Society of America, vol. 25, pp. 1355-1357, Sep. 2000.Applicant
- “3000 Times Grating Compress or with Positive Group Velocity Dispersion” by Oscar Eduardo Martinez, in the IEEE, vol. QE-23, pp. 59-64, Jan. 1987.Applicant
- “Image Enhancement in Optical Coherence Tomography Using Deconvolution” by Kulkarni, et al., in the Electronics Letters , vol. 33, pp. 1365-1367, Jul. 1997.Applicant
- “Signal Processing for Improving Field Cross-Correlation Function in Optical Coherence Tomography” by Bashkansky, et al., in the Optics & Photonics News, vol. 9, pp. 8137-8138, May 1998.Applicant
- “Phase-Domain Processing of Optical Coherence Tomography Images” by Yung, et al., in the Journal of Biomedical Optics, vol. 4, pp. 125-136, Jan. 1999.Applicant
- “In Vivo Endoscopic Optical Coherence Tomography” by Tearney, et al., in the Science vol. 276, Jun. 1997.Applicant
- “In Vivo Ultrahigh-Resolution Optical Coherence Tomography” by W. Drexler et al., Opt. Lett. vol. 24, pp. 1221-1223, Sep. 1999.Applicant
- Office Action dated Dec. 6, 2006 for U.S. Appl. No. 10/997,789.Applicant
- Elliott, K. H. “The use of commercial CCD cameras as linear detectors in the physics undergraduate teaching laboratory”, European Journal of Physics 19, 1998, pp. 107-117.Applicant
- Lauer, V. “New approach to optical diffraction tomography yielding a vector equation of diffraction tomography and a novel tomographic microscope”, Journal of Microscopy vol. 205, Issue 2, 2002, pp. 165-176.Applicant
- Yu, P. et al. “Imaging of tumor necroses using full-frame optical coherence imaging”, Proceedings of SPIE vol. 4956, 2003, pp. 34-41.Applicant
- Zhao, Y. et al. “Three-dimensional reconstruction of in vivo blood vessels in human skin using phase-resolved optical Doppler tomography”, IEEE Journal of Selected Topics in Quantum Electronics 7.6 (2001): 931-935.Applicant
- Office Action dated Dec. 18, 2006 for U.S. Appl. No. 10/501,276.Applicant
- Devesa, Susan S. et al. (1998) “Changing Patterns in the Incidence of Esophegeal and Gastric Carcinoma in the United States.” American Cancer Society vol. 83, No. 10 pp. 2049-2053.Applicant
- Barr, H et al. (2005) “Endoscopic Therapy for Barrett's Oesophaugs” Gut vol. 54:875-884.Applicant
- Johnston, Mark H.(2005) “Technology Insight: Ablative Techniques for Barrett's Esophagus—Current and Emerging Trends” www.Nature.com/clinicalpractice/gasthep.Applicant
- Falk, Gary W. et al. (1997) “Surveillance of Patients with Barrett's Esophagus for Dysplasia and Cancer with Ballon Cytology” Gastrorenterology vol. 112, pp. 1787-1797.Applicant
- Sepchler, Stuart Jon. (1997) “Barrett's Esophagus: Should We Brush off this Balloning Problem?” Gastroenterology vol. 112, pp. 2138-2152.Applicant
- Froehly, J. et al. (2003) “Multiplexed 3D Imaging Using Wavelength Encoded Spectral Interferometry: A Proof of Principle” Optics Communications vol. 222, pp. 127-136.Applicant
- Kubba A.K. et al. (1999) “Role of p53 Assessment in Management of Barrett's Esophagus” Digestive Disease and Sciences vol. 44, No. 4. pp. 659-667.Applicant
- Reid, Brian J. (2001) “p53 and Neoplastic Progression in Barrett'Esophagus” The American Journal of Gastroenterology vol. 96, No. 5, pp. 1321-1323.Applicant
- Sharma, P. et al.(2003) “Magnification Chromoendoscopy for the Detection of Intestinal Metaplasia and Dysplasia in Barrett's Oesophagus” Gut vol. 52, pp. 24-27.Applicant
- Kuipers E.J et al. (2005) “Diagnostic and Therapeutic Endoscopy” Journal of Surgical Oncology vol. 92, pp. 203-209.Applicant
- Georgakoudi, Irene et al. (2001) “Fluorescence, Reflectance, and Light-Scattering Spectroscopy for Evaluating Dysplasia in Patients with Barrett's Esophagus” Gastroenterology vol. 120, pp. 1620-1629.Applicant
- Adrain, Alyn L. et al. (1997) “High-Resolution for the Identification Sonography is a Sensitive Modality for the Identification of Barrett's Meaplasia” Gastrointestinal Endoscopy vol. 46, No. 2, pp. 147-151.Applicant
- Canto, Marcia Irene et al (1999) “Vital Staining and Barrett's Esophagus” Gastrointestinal Endoscopy vol. 49, No. 3, part 2, pp. 12-16.Applicant
- Evans, John A. et al. (2006) “Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett's Esophagus” Clinical Gastroenterology and Hepatology vol.4, pp. 38-3.Applicant
- Poneros, John M. et al. (2001) “Diagnosis of Specialized Intestinal Metaplasia by Optical Coherence Tomography” Gastroenterology vol. 120, pp. 7-12.Applicant
- Ho, W. Y. et al. (2005) “115 KHz Tuning Repetition Rate Ultrahigh-Speed Wavelength-Swept Semiconductor Laser” Optics Letters col. 30, No. 23, pp. 3159-3161.Applicant
- Brown, Stanley B. et al. (2004) “The Present and Future Role of Photodynamic Therapy in Cancer Treatment” The Lancet Oncology vol. 5, pp. 497-508.Applicant
- Boogert, Jolanda Van Den et al. (1999) “Endoscopic Ablation Therapy for Barrett's Esophagua with High-Grade Dysplasia: A Review” The American Journal of Gastroenterology vol. 94, No. 5, pp. 1153-1160.Applicant
- Sampliner, Richard E. et al. (1996) “Reversal of Barrett's Esophagus with Acid Suppression and Multipolar Electrocoagulation: Preliminary Results” Gastrointestinal Endoscopy vol. 44, No. 5, pp. 532-535.Applicant
- Sampliner, Richard E. (2004) “Endoscopic Ablative Therapy for Barrett's Esophagus: Current Status” Gastrointestinal Endoscopy vol. 59, No. 1, pp. 66-69.Applicant
- Soetikno, Roy M. et al. (2003) “Endoscopic Mucosal resection” Gastrointestinal Endoscopy vol.57, No. 4, pp. 567-579.Applicant
- Ganz, Robert A. et al. (2004) “Complete Ablation of Esophageal Epithelium with a Balloon-based Bipolar Electrode: A Phased Evaluation in the Porcine and in the Human Esophagus” Gastrointestinal Endoscopy vol. 60, No. 6, pp. 1002-1010.Applicant
- Pfefer, Jorje at al. (2006) “Performance of the Aer-O-Scope, A Pneumatic, Self Propelling, Self Navigating Colonoscope in Animal Experiments” Gastrointestinal Endoscopy vol. 63, No. 5, pp. AB223.Applicant
- Overholt, Bergein F. et al. (1999) “Photodynamic Therapy for Barrett's Esophagus: Follow-Up in 100 Patients” Gastrointestinal Endoscopy vol. 49, No. 1, pp. 1-7.Applicant
- Vogel, Alfred et al. (2003) “Mechanisms of Pulsed Laser Ablation of Biological Tissues” American Chemical Society vol. 103, pp. 577-644.Applicant
- McKenzie, A. L. (1990) “Physics of Thermal Processes in Laser-Tissue Interaction” Phys. Med. Biol vol. 35, No. 9, pp. 1175-1209.Applicant
- Anderson, R. Rox et al. (1983) “Selective Photothermolysis” Precise Microsurgery by Selective Absorption of Pulsed Radiation Science vol. 220, No. 4596, pp. 524-527.Applicant
- Jacques, Steven L. (1993) “Role of Tissue Optics and Pulse Duration on Tissue Effects During High-Power Laser Irradiation” Applied Optics vol. 32, No. 13, pp. 2447-2454.Applicant
- Nahen, Kester et al. (1999) “Investigations on Acosustic On-Line Monitoring of IR Laser Ablation of burned Skin” Lasers in Surgery and Medicine vol. 25, pp. 69-78.Applicant
- Jerath, Maya R. et al. (1993) “Calibrated Real-Time Control of Lesion Size Based on Reflectance Images” Applied Optics vol. 32, No. 7, pp. 1200-1209.Applicant
- Jerath, Maya R. et al (1992) “Dynamic Optical Property Changes: Implications for Reflectance Feedback Control of Photocoagulation” Journal of Photochemical, Photobiology, B: Biol vol. 16, pp. 113-126.Applicant
- Deckelbaum, Lawrence I. (1994) “Coronary Laser Angioplasty” Lasers in Surgery and Medicine vol. 14, pp. 101-110.Applicant
- Kim, B.M. et al. (1998) “Optical Feedback Signal for Ultrashort Laser Pulse Ablation of Tissue” Applied Surface Science vol. 127-129, pp. 857-862.Applicant
- Brinkman, Ralf et al. (1996) “Analysis of Cavitation Dynamics During Pulsed Laser Tissue Ablation by Optical On-Line Monitoring” IEEE Journal of Selected Topics in Quantum Electronics vol. 2, No. 4, pp. 826-835.Applicant
- Whelan, W.M. et al. (2005) “A novel Strategy for Monitoring Laser Thermal Therapy Based on Changes in Optothermal Properties of Heated Tissues” International Journal of Thermophysics vol. 26., No. 1, pp. 233-241.Applicant
- Thomsen, Sharon et al. (1990) “Microscopic Correlates of Macroscopic Optical Property Changes During Thermal Coagulation of Myocardium” SPIE vol. 1202, pp. 2-11.Applicant
- Khan, Misban Huzaira et al. (2005) “Intradermally Focused Infrared Laser Pulses: Thermal Effects at Defined Tissue Depths” Lasers in Surgery and Medicine vol. 36, pp. 270-280.Applicant
- Neumann, R.A. et al. (1991) “Enzyme Histochemical Analysis of Cell Viability After Argon Laser-Induced Coagulation Necrosis of the Skin” Journal of the American Academy of Dermatology vol. 25, No. 6, pp. 991-998.Applicant
- Nadkarni, Seemantini K. et al (2005) “Charaterization of Atherosclerotic Plaques by Laser Speckle Imaging” Circulation vol. 112, pp. 885-892.Applicant
- Zimnyakov, Dmitry A. et al (2002) “Speckle-Contrast Monitoring of Tissue Thermal Modification” Applied Optics vol. 41, No. 28, pp. 5989-5996.Applicant
- Morelli, J.G., et al (1986) “Tunable Dye Laser (577 nm) Treatment of Port Wine Stains” Lasers in Surgery and Medicine vol. 6, pp. 94-99.Applicant
- French, P.M.W. et al. (1993) “Continuous-wave Mode-Locked Cr4+: YAG Laser” Optics Letters vol. 18, No. 1, pp. 39-41.Applicant
- Sennaroglu, Alphan at al. (1995) “Efficient Continuous-Wave Chromium-Doped YAG Laser” Journal of Optical Society of America vol. 12, No. 5, pp. 930-937.Applicant
- Bouma, B et al. (1994) “Hybrid Mode Locking of a Flash-Lamp-Pumped Ti: A12O3 Laser” Optics Letters vol. 19, No. 22, pp. 1858-1860.Applicant
- Bouma, B et al. (1995) “High Resolution Optical Coherence Tomography Imaging Using a Mode-Locked Ti: A12O3 Laser Source” Optics Letters vol. 20, No. 13, pp. 1486-1488.Applicant
- Fernández, Cabrera Delia et al. “Automated detection of retinal layer structures on optical coherence tomography images”, Optics Express vol. 13, No. 25, Oct. 4, 2005, pp. 10200-10216.Applicant
- Ishikawa, Hiroshi et al. “Macular Segmentation with optical coherence tomography”, Investigative Ophthalmology & Visual Science, vol. 46, No. 6, Jun. 2005, pp. 2012-2017.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/043951.Applicant
- International Search Report for International Patent application No. PCT/US2005/043951.Applicant
- Erdelyi et al. “Generation of diffraction-free beams for applications in optical microlithography”, J. Vac. Sci. Technol. B 15 (12), Mar./Apr. 1997, pp. 287-292.Applicant
- International Search Report for International Patent application No. PCT/US2005/023664.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/023664.Applicant
- Tearney et al., “Spectrally encoded miniature endoscopy” Optical Society of America; Optical Letters vol. 27, No. 6, Mar. 15, 2002; pp. 412-414.Applicant
- Yelin et al., “Double-clad Fiber for Endoscopy” Optical Society of America; Optical Letters vol. 29, No. 20, Oct. 16, 2005; pp. 2408-2410.Applicant
- International Search Report for International Patent application No. PCT/US2001/049704.Applicant
- International Search Report for International Patent application No. PCT/US2004/039454.Applicant
- International Written Opinion for International Patent application No. PCT/US2004/039454.Applicant
- PCT International Preliminary Report on Patentability for International Application No. PCT/US2004/038404 dated Jun. 2, 2006.Applicant
- Notice of Reasons for Rejection and English translation for Japanese Patent Application No. 2002-538830.Applicant
- De Boer, Johannes F. et al., “Review of Polarization Sensitive Optical Coherence Tomography and Stokes Vector Determination,” Journal of Biomedical Optics, vol. 7, No. 3, Jul. 2002, pp. 359-371.Applicant
- Jiao, Shuliang et al., “Depth-Resolved Two-Dimensional Stokes Vectors of Backscattered Light and Mueller Matrices of Biological Tissue Measured with Optical Coherence Tomography,” Applied Optics, vol. 39, No. 34, Dec. 1, 2000, pp. 6318-6324.Applicant
- Park, B. Hyle et al., “In Vivo Burn Depth Determination by High-Speed Fiber-Based Polarization Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 6 No. 4, Oct. 2001, pp. 474-479.Applicant
- Roth, Jonathan E. et al., “Simplified Method for Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 26, No. 14, Jul. 15, 2001, pp. 1069-1071.Applicant
- Hitzenberger, Christopher K. et al., “Measurement and Imaging of Birefringence and Optic Axis Orientation by Phase Resolved Polarization Sensitive Optical Coherence Tomography,” Optics Express, vol. 9, No. 13, Dec. 17, 2001, pp. 780-790.Applicant
- Wang, Xueding et al., “Propagation of Polarized Light in Birefringent Turbid Media: Time-Resolved Simulations,” Optical Imaging Laboratory, Biomedical Engineering Program, Texas A&M University.Applicant
- Wong, Brian J.F. et al., “Optical Coherence Tomography of the Rat Cochlea,” Journal of Biomedical Optics, vol. 5, No. 4, Oct. 2000, pp. 367-370.Applicant
- Yao, Gang et al., “Propagation of Polarized Light in Turbid Media: Simulated Animation Sequences,” Optics Express, vol. 7, No. 5, Aug. 28, 2000, pp. 198-203.Applicant
- Wang, Xiao-Jun et al., “Characterization of Dentin and Enamel by Use of Optical Coherence Tomography,” Applied Optics, vol. 38, No. 10, Apr. 1, 1999, pp. 2092-2096.Applicant
- De Boer, Johannes F. et al., “Determination of the Depth-Resolved Stokes Parameters of Light Backscattered from Turbid Media by use of Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 24, No. 5, Mar. 1, 1999, pp. 300-302.Applicant
- Ducros, Mathieu G. et al., “Polarization Sensitive Optical Coherence Tomography of the Rabbit Eye,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, No. 4, Jul./Aug. 1999, pp. 1159-1167.Applicant
- Groner, Warren et al., “Orthogonal Polarization Spectral Imaging: A New Method for the Study of the Microcirculation,” Nature Medicine Inc., vol. 5 No. 10, Oct. 1999, pp. 1209-1213.Applicant
- De Boer, Johannes F. et al., “Polarization Effects in Optical Coherence Tomography of Various Viological Tissues,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, No. 4, Jul./Aug. 1999, pp. 1200-1204.Applicant
- Yao, Gang et al., “Two-Dimensional Depth-Resolved Mueller Matrix Characterization of Biological Tissue by Optical Coherence Tomography,” Optics Letters, Apr. 15, 1999, vol. 24, No. 8, pp. 537-539.Applicant
- Lu, Shih-Yau et al., “Homogeneous and Inhomogeneous Jones Matrices,” J. Opt. Soc. Am. A., vol. 11, No. 2, Feb. 1994, pp. 766-773.Applicant
- Bickel, S. William et al., “Stokes Vectors, Mueller Matrices, and Polarized Scattered Light,” Am. J. Phys., vol. 53, No. 5, May 1985 pp. 468-478.Applicant
- Bréhonnet, F. Le Roy et al., “Optical Media and Target Characterization by Mueller Matrix Decomposition,” J. Phys. D: Appl. Phys. 29, 1996, pp. 34-38.Applicant
- Cameron, Brent D. et al., “Measurement and Calculation of the Two-Dimensional Backscattering Mueller Matrix of a Turbid Medium,” Optics Letters, vol. 23, No. 7, Apr. 1, 1998, pp. 485-487.Applicant
- De Boer, Johannes F. et al., “Two-Dimensional Birefringence Imaging in Biological Tissue by Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 22, No. 12, Jun. 15, 1997, pp. 934-936.Applicant
- De Boer, Johannes F. et al., “Imaging Thermally Damaged Tissue by Polarization Sensitive Optical Coherence Tomography,” Optics Express, vol. 3, No. 6, Sep. Sep. 14, 1998, pp. 212-218.Applicant
- Everett, M.J. et al., “Birefringence Characterization of Biological Tissue by Use of Optical Coherence Tomography,” Optics Letters, vol. 23, No. 3, Feb. 1, 1998, pp. 228-230.Applicant
- Hee, Michael R. et al., “Polarization-Sensitive Low-Coherence Reflectometer for Birefringence Characterization and Ranging,” J. Opt. Soc. Am. B., vol. 9, No. 6, Jun. 1992, pp. 903-908.Applicant
- Barakat, Richard, “Statistics of the Stokes Parameters,” J. Opt. Soc. Am. B., vol. 4, No. 7, Jul. 1987, pp. 1256-1263.Applicant
- Schmitt, J.M. et al., “Cross-Polarized Backscatter in Optical Coherence Tomography of Biological Tissue,” Optics Letters, vol. 23, No. 13, Jul. 1, 1998, pp. 1060-1062.Applicant
- Schoenenberger, Klaus et al., “Mapping of Birefringence and Thermal Damage in Tissue by use of Polarization-Sensitive Optical Coherence Tomography,” Applied Optics, vol. 37, No. 25, Sep. 1, 1998, pp. 6026-6036.Applicant
- Pierce, Mark C. et al., “Simultaneous Intensity, Birefringence, and Flow Measurements with High-Speed Fiber-Based Optical Coherence Tomography,” Optics Letters, vol. 27, No. 17, Sep. 1, 2002, pp. 1534-1536.Applicant
- De Boer, Johannes F. et al., “Review of Polarization Sensitive Optical Coherence Tomography and Stokes Vector Determination,” Journal of Biomedical Optics, Jul. 2002, vol. 7, No. 3, pp. 359-371.Applicant
- Fried, Daniel et al., “Imaging Caries Lesions and Lesion Progression with Polarization Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 7, No. 4, Oct. 2002, pp. 618-627.Applicant
- Jiao, Shuliang et al., “Two-Dimensional Depth-Resolved Mueller Matrix of Biological Tissue Measured with Double-Beam Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 27, No. 2, Jan. 15, 2002, pp. 101-103.Applicant
- Jiao, Shuliang et al., “Jones-Matrix Imaging of Biological Tissues with Quadruple-Channel Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 7, No. 3, Jul. 2002, pp. 350-358.Applicant
- Kuranov, R.V. et al., “Complementary Use of Cross-Polarization and Standard OCT for Differential Diagnosis of Pathological Tissues,” Optics Express, vol. 10, No. 15, Jul. 29, 2002, pp. 707-713.Applicant
- Cense, Barry et al., “In Vivo Depth-Resolved Birefringence Measurements of the Human Retinal Nerve Fiber Layer by Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 27, No. 18, Sep. 15, 2002, pp. 1610-1612.Applicant
- Ren, Hongwu et al., “Phase-Resolved Functional Optical Coherence Tomography: Simultaneous Imaging of In Situ Tissue Structure, Blood Flow Velocity, Standard Deviation, Birefringence, and Stokes Vectors in Human Skin,” Optics Letters, vol. 27, No. 19, Oct. 1, 2002, pp. 1702-1704.Applicant
- Tripathi, Renu et al., “Spectral Shaping for Non-Gaussian Source Spectra in Optical Coherence Tomography,” Optics Letters, vol. 27, No. 6, Mar. 15, 2002, pp. 406-408.Applicant
- Yasuno, Y. et al., “Birefringence Imaging of Human Skin by Polarization-Sensitive Spectral Interferometric Optical Coherence Tomography,” Optics Letters, vol. 27, No. 20, Oct. 15, 2002 pp. 1803-1805.Applicant
- White, Brian R. et al., “In Vivo Dynamic Human Retinal Blood Flow Imaging Using Ultra-High-Speed Spectral Domain Optical Doppler Tomography,” Optics Express, vol. 11, No. 25, Dec. 15, 2003, pp. 3490-3497.Applicant
- De Boer, Johannes F. et al., “Improved Signal-to-Noise Ratio in Spectral-Domain Compared with Time-Domain Optical Coherence Tomography,” Optics Letters, vol. 28, No. 21, Nov. 1, 2003, pp. 2067-2069.Applicant
- Jiao, Shuliang et al., “Optical-Fiber-Based Mueller Optical Coherence Tomography,” Optics Letters, vol. 28, No. 14, Jul. 15, 2003, pp. 1206-1208.Applicant
- Jiao, Shuliang et al., “Contrast Mechanisms in Polarization-Sensitive Mueller-Matrix Optical Coherence Tomography and Application in Burn Imaging,” Applied Optics, vol. 42, No. 25, Sep. 1, 2003, pp. 5191-5197.Applicant
- Moreau, Julien et al., “Full-Field Birefringence Imaging by Thermal-Light Polarization-Sensitive Optical Coherence Tomography. I. Theory,” Applied Optics, vol. 42, No. 19, Jul. 1, 2003, pp. 3800-3810.Applicant
- Moreau, Julien et al., “Full-Field Birefringence Imaging by Thermal-Light Polarization-Sensitive Optical Coherence Tomography. II. Instrument and Results,” Applied Optics, vol. 42, No. 19, Jul. 1, 2003, pp. 3811-3818.Applicant
- Morgan, Stephen P. et al., “Surface-Reflection Elimination in Polarization Imaging of Superficial Tissue,” Optics Letters, vol. 28, No. 2, Jan. 15, 2003, pp. 114-116.Applicant
- Oh, Jung-Taek et al., “Polarization-Sensitive Optical Coherence Tomography for Photoelasticity Testing of Glass/Epoxy Composites,” Optics Express, vol. 11, No. 14, Jul. 14, 2003, pp. 1669-1676.Applicant
- Park, B. Hyle et al., “Real-Time Multi-Functional Optical Coherence Tomography,” Optics Express, vol. 11, No. 7, Apr. 7, 2003, pp. 782-793.Applicant
- Shribak, Michael et al., “Techniques for Fast and Sensitive Measurements of Two-Dimensional Birefringence Distributions,” Applied Optics, vol. 42, No. 16, Jun. 1, 2003, pp. 3009-3017.Applicant
- Somervell, A.R.D. et al., “Direct Measurement of Fringe Amplitude and Phase Using a Heterodyne Interferometer Operating in Broadband Light,” Elsevier, Optics Communications, Oct. 2003.Applicant
- Stifter, D. et al., “Polarisation-Sensitive Optical Coherence Tomography for Material Characterisation and Strain-Field Mapping,” Applied Physics A 76, Materials Science & Processing, Jan. 2003, pp. 947-951.Applicant
- Davé, Digant P. et al., “Polarization-Maintaining Fiber-Based Optical Low-Coherence Reflectometer for Characterization and Ranging of Birefringence,” Optics Letters, vol. 28, No. 19, Oct. 1, 2003, pp. 1775-1777.Applicant
- Yang, Ying et al., “Observations of Birefringence in Tissues from Optic-Fibre-Based Optical Coherence Tomography,” Measurement Science and Technology, Nov. 2002, pp. 41-46.Applicant
- Yun, S.H. et al., “High-Speed Optical Frequency-Domain Imaging,” Optics Express, vol. 11, No. 22, Nov. 3, 2003, pp. 2953-2963.Applicant
- Yun, S.H. et al., “High-Speed Spectral-Domain Optical Coherence Tomography at 1.3 μm Wavelength,” Optics Express, vol. 11, No. 26, Dec. 29, 2003, pp. 3598-3604.Applicant
- Zhang, Jun et al., “Determination of Birefringence and Absolute Optic Axis Orientation Using Polarization-Sensitive Optical Coherence Tomography with PM Fibers,” Optics Express, vol. 11, No. 24, Dec. 1, 2003, pp. 3262-3270.Applicant
- Pircher, Michael et al., “Three Dimensional Polarization Sensitive OCT of Human Skin In Vivo,” Optical Society of America.Applicant
- Götzinger, Erich et al., “Measurement and Imaging of Birefringent Properties of the Human Cornea with Phase-Resolved, Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 94-102.Applicant
- Guo, Shuguang et al., “Depth-Resolved Birefringence and Differential Optical Axis Orientation Measurements with Finer-based Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 29, No. 17, Sep. 1, 2004, pp. 2025-2027.Applicant
- Huang, Xiang-Run et al.,“Variation of Peripapillary Retinal Nerve Fiber Layer Birefringence in Normal Human Subjects,” Investigative Ophthalmology & Visual Science, vol. 45, No. 9, Sep. 2004, pp. 3073-3080.Applicant
- Matcher, Stephen J. et al., “The Collagen Structure of Bovine Intervertebral Disc Studied Using Polarization-Sensitive Optical Coherence Tomography,” Physics in Medicine and Biology, 2004, pp. 1295-1306.Applicant
- Nassif, Nader et al., “In Vivo Human Retinal Imaging by Ultrahigh-Speed Spectral Domain Optical Coherence Tomography,” Optics Letters, vol. 29, No. 5, Mar. 1, 2004, pp. 480-482.Applicant
- Nassif, N.A. et al., “In Vivo High-Resolution Video-Rate Spectral-Domain Optical Coherence Tomography of the Human Retina and Optic Nerve,” Optics Express, vol. 12, No. 3, Feb. 9, 2004, pp. 367-376.Applicant
- Park, B. Hyle et al., Comment on “Optical-Fiber-Based Mueller Optical Coherence Tomography,” Optics Letters, vol. 29, No. 24, Dec. 15, 2004, pp. 2873-2874.Applicant
- Park, B. Hyle et al., “Jones Matrix Analysis for a Polarization-Sensitive Optical Coherence Tomography System Using Fiber-Optic Components,” Optics Letters, vol. 29, No. 21, Nov. 1, 2004, pp. 2512-2514.Applicant
- Pierce, Mark C. et al., “Collagen Denaturation can be Quantified in Burned Human Skin Using Polarization-Sensitive Optical Coherence Tomography,” Elsevier, Burns, 2004, pp. 511-517.Applicant
- Pierce, Mark C. et al., “Advances in Optical Coherence Tomography Imaging for Dermatology,” The Society for Investigative Dermatology, Inc. 2004, pp. 458-463.Applicant
- Pierce, Mark C. et al., “Birefringence Measurements in Human Skin Using Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 2, Mar./Apr. 2004, pp. 287-291.Applicant
- Cense, Barry et al., “In Vivo Birefringence and Thickness Measurements of the Human Retinal Nerve Fiber Layer Using Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 121-125.Applicant
- Pircher, Michael et al., “Imaging of Polarization Properties of Human Retina in Vivo with Phase Resolved Transversal PS-OCT,” Optics Express, vol. 12, No. 24, Nov. 29, 2004 pp. 5940-5951.Applicant
- Pircher, Michael et al., “Transversal Phase Resolved Polarization Sensitive Optical Coherence Tomography,” Physics in Medicine & Biology, 2004, pp. 1257-1263.Applicant
- Srinivas, Shyam M. et al., “Determination of Burn Depth by Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 207-212.Applicant
- Strasswimmer, John et al., “Polarization-Sensitive Optical Coherence Tomography of Invasive Basal Cell Carcinoma,” Journal of Biomedical Optics, vol. 9, No. 2, Mar./Apr. 2004, pp. 292-298.Applicant
- Todorovi{hacek over (s)}, Milo{hacek over (s)}et al., “Determination of Local Polarization Properties of Biological Samples in the Presence of Diattenuation by use of Mueller Optical Coherence Tomography,” Optics Letters, vol. 29, No. 20, Oct. 15, 2004, pp. 2402-2404.Applicant
- Yasuno, Yoshiaki et al., “Polarization-Sensitive Complex Fourier Domain Optical Coherence Tomography for Jones Matrix Imaging of Biological Samples,” Applied Physics Letters, vol. 85, No. 15, Oct. 11, 2004, pp. 3023-3025.Applicant
- Hariri, Lida P. et al. “Endoscopic Optical Coherence Tomography and Laser-Induced Fluorescence Spectroscopy in a Murine Colon Cancer Model”, Laser in Surgery and Medicine, vol. 38, 2006, pp. 305-313.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2006/031905 dated May 3, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060481 dated May 23, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060717 dated May 24, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060319 dated Jun. 6, 2007.Applicant
- D. Yelin et al., “Three-dimensional imaging using spectral encoding heterodyne interferometry”, Optics Letters, Jul. 15, 2005, vol. 30, No. 14, pp. 1794-1796.Applicant
- Akiba, Masahiro et al. “En-face optical coherence imaging for three-dimensional microscopy”, SPIE, 2002, pp. 8-15.Applicant
- Office Action dated Aug. 10, 2007 for U.S. Appl. No. 10/997,789.Applicant
- Office Action dated Feb. 2, 2007 for U.S. Appl. No. 11/174,425.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060657 dated Aug. 13, 2007.Applicant
- Lewis, Neil E. et al., “Applications of Fourier Transform Infrared Imaging Microscopy in Neurotoxicity”, Annals New York Academy of Sciences, pp. 234-246.Applicant
- Joo, Chulmin et al., Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging, Optics Letters, Aug. 15, 2005, vol. 30, No. 16, pp. 2131-2133.Applicant
- Guo, Bujin et al., “Laser-based mid-infrared reflectance imaging of biological tissues”, Optics Express, Jan. 12, 2004, vol. 12, No. 1, pp. 208-219.Applicant
- Office Action dated Mar. 28, 2007 for U.S. Appl. No. 11/241,907.Applicant
- Office Action dated May 23, 2007 for U.S. Appl. No. 10/406,751.Applicant
- Office Action dated May 23, 2007 for U.S. Appl. No. 10/551,735.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/061815 dated Aug. 2, 2007.Applicant
- Sir Randall, John et al., “Brillouin scattering in systems of biological significance”, Phil. Trans. R. Soc. Lond. A 293, 1979, pp. 341-348.Applicant
- Takagi, Yasunari, “Application of a microscope to Brillouin scattering spectroscopy”, Review of Scientific Instruments, No. 12, Dec. 1992, pp. 5552-5555.Applicant
- Lees, S. et al., “Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”, Connective Tissue Research, 1990, vol. 24, pp. 187-205.Applicant
- Berovic, N. “Observation of Brillion scattering from single muscle fibers”, European Biophysics Journal, 1989, vol. 17, pp. 69-74.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/062465 dated Aug. 8, 2007.Applicant
- Pyhtila John W. et al., “Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometry”, Optics Society of America, 2004.Applicant
- Pyhtila John W. et al., “Determining nuclear morphology using an improved angle-resolved low coherence interferometry system”, Optics Express, Dec. 15, 2003, vol. 11, No. 25, pp. 3473-3484.Applicant
- Desjardins A.E., et al., “Speckle reduction in OCT using massively-parallel detection and frequency-domain ranging”, Optics Express, May 15, 2006, vol. 14, No. 11, pp. 4736-4745.Applicant
- Nadkarni, Seemantini K., et al., “Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images”, Journal of Biomedical Optics, vol. 11 Mar./Apr. 2006, pp. 021006-1-021006-8.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/066017 dated Aug. 30, 2007.Applicant
- Yamanari M. et al., “Polarization sensitive Fourier domain optical coherence tomography with continuous polarization modulation”, Proc. of SPIE, vol. 6079, 2006.Applicant
- Zhang Jun et al., “Full range polarization-sensitive Fourier domain optical coherence tomography”, Optics Express, Nov. 29, 2004, vol. 12, No. 24, pp. 6033-6039.Applicant
- European Patent Office Search report for Application No. 01991092.6-2305 dated Jan. 12, 2006.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060670 dated Sep. 21, 2007.Applicant
- J. M. Schmitt et al., “Speckle in Optical Coherence Tomography: An Overview”, SPIE vol. 3726, pp. 450-461.Applicant
- Office Action dated Oct. 11, 2007 for U.S. Appl. No. 11/534,095.Applicant
- Office Action dated Oct. 9, 2007 for U.S. Appl. No. 09/709,162.Applicant
- Notice of Allowance dated Oct. 3, 2007 for U.S. Appl. No. 11/225,840.Applicant
- Siavash Yazdanfar et al., “In Vivo imaging in blood flow in human retinal vessels using color Doppler optical coherence tomography”, SPIE, 1999 vol. 3598, pp. 177-184.Applicant
- Office Action dated Oct. 30, 2007 for U.S. Appl. No. 11/670,069.Applicant
- Office Action dated Aug. 24, 2006 for U.S. Appl. No. 10/137,749.Applicant
- Barry Cense et al., “Spectral-domain polarization-sensitive optical coherence tomography at 850nm”, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, pp. 159-162.Applicant
- A. Ymeti et al., “Integration of microfluidics with a four-channel integrated optical Young interferometer immunosensor”, Biosensors and Bioelectronics, Elsevier Science Publishers, 2005, pp. 1417-1421.Applicant
- PCT International Search Report for Application No. PCT/US2006/018865 filed May 5, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2006/018865 filed May 5, 2006.Applicant
- John M. Poneros, “Diagnosis of Barrett's esophagus using optical coherence tomography”, Gastrointestinal Endoscopy clinics of North America, 14 (2004) pp. 573-588.Applicant
- P.F. Escobar et al., “Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva”, Int. Journal of Gynecological Cancer 2004, 14, pp. 470-474.Applicant
- Ko T et al., “Ultrahigh resolution in vivo versus ex vivo OCT imaging and tissue preservation”, Conference on Lasers and electro-optics, 2001, pp. 252-253.Applicant
- Paul M. Ripley et al., “A comparison of Artificial Intelligence techniques for spectral classification in the diagnosis of human pathologies based upon optical biopsy”, Journal of Optical Society of America, 2000, pp. 217-219.Applicant
- Wolfgang Drexler et al., “Ultrahigh-resolution optical coherence tomography”, Journal of Biomedical Optics Spie USA, 2004, pp. 47-74.Applicant
- PCT International Search Report for Application No. PCT/US2006/016677 filed Apr. 28, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2006/016677 filed Apr. 28, 2006.Applicant
- Office Action dated Nov. 13, 2006 for U.S. Appl. No. 10/501,268.Applicant
- Office Action dated Nov. 20, 2006 for U.S. Appl. No. 09/709,162.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2004/023585 filed Jul. 23, 2004.Applicant
- Poneros er al: “Optical Coherence Tomography of the Biliary Tree During ERCP”, Gastrointestinal Endoscopy, Elsevier, NL, vol. 55, No. 1, Jan. 1, 2002, pp. 84-88.Applicant
- Fu L e tal: double-Clad Photonic Crystal Fiber Coupler for compact Nonlinear Optical Microscopy Imaging, Optics Letters, OSA, Optical Society of America, vol. 31, No. 10, May 15, 2006, pp. 1471-1473.Applicant
- The Japanese Office Action for Application No. 2015-021997 dated Feb. 29, 2016.Applicant
- The Eurpoean Office Action for Application No. 10182896.0 dated Apr. 14, 2015.Applicant
- The Eurpoean Office Action for Application No. 02734125.4 dated Mar. 18, 2015.Applicant