US 9,533,344 B2Grant
Three-dimensional complex coil
Issue Date:2017-01-03
•8 Claims
•11 Drawing Sheets
Abstract
A complex coil and a fixture for forming same configured such that loops are formed having various configurations relative to each other. The configurations provide improved thrombus formation and reduced rotation or tumbling once implanted. The complex coil is formed of a material that may deformed for purposes of placing the complex coil into a catheter and returns to a complex shape that includes said loops once deployed.
Metadata
Assignee
- MicroVention, Inc.
Inventors
- Richard Monetti
- George Martinez
- Matthew Fitz
- Damian Jonathan Perez
Application Information
Application Number:US 13/278,008
Filing Date:2011-10-20
Priority Date:2005-11-17
Art Unit:3726
Classifications
IPC:
B21F45/00A61B17/12A61B17/122A61B17/00
Field of Search:
B21F 3/10B21F 35/003B21F 45/00B21F 45/008A61B 17/1214A61B 17/12154A61B 17/12145A61B 17/1219A61B 2017/00867A61B 2017/00526A61B 17/12022A61B 17/1215A61B 17/12113A61B 17/12099A61B 17/12109A61B 17/12118A61B 17/12163A61M 2025/1052
Patent Drawings (11 sheets)
Description
Cross-Reference to Related Documents
[0001] This application is a continuation of U.S. patent application Ser. No. 11/560,251 filed Nov. 15, 2006 now U.S. Pat. No. 8,066,036 entitled Three Dimensional Complex Coil, which claims priority from U.S. Provisional Patent Application Ser. No. 60/738,087, filed Nov. 17, 2005, by Monetti et al. entitled Three Dimensional Complex Coil and U.S. Provisional Patent Application Ser. No. 60/822,656, filed Aug. 17, 2006, by Monetti et al. entitled Three Dimensional Complex Coil, all of which are hereby incorporated by reference in their entireties.
Background of the Invention
[0002] The prior art contemplates a number of methods and devices for treating a body aneurysm using three-dimensional (3-D) shaped coils, sometimes referred to as “complex” coils. For example, Horton U.S. Pat. No. 5,766,219, the contents of which are incorporated by reference, shows a hollow structure. Phelps U.S. Pat. No. 5,382,259 and Ritchart U.S. Pat. No. 4,994,069, the contents of which are incorporated by reference, show other 3-D coil designs. Teoh U.S. Pat. No. 6,635,069, the contents of which are incorporated by reference, teaches a series of non-overlapping loops. Wallace U.S. Pat. No. 6,860,893, the contents of which are incorporated by reference, shows complex coils. Ferrera U.S. Pat. No. 6,638,291, the contents of which are incorporated by reference, shows a device similar to Teoh's and Wallace's except that a J-shaped proximal segment extends away from the complex portion of the device.
[0003] The following patents provide further background and are also incorporated herein by reference: Guglielmi U.S. Pat. No. 6,010,498; Gandhi U.S. Pat. No. 6,478,773; Schaefer 2002/0107534; Mariant U.S. Pat. No. 5,957,948; Pham U.S. Pat. No. 5,911,731; Lahille U.S. Pat. No. 4,957,501; Porter 2005/0192618; Wallace 2005/0192621.
[0004] There is, however an ongoing need to provide more advanced and improved complex coils so as to provide better treatment of an aneurysm.
Objects and Summary of the Invention
[0005] It is therefore an object of the invention to provide improved devices and methods for treating an aneurysm over the prior art.
[0006] This object and other objects not specifically enumerated here are addressed by the invention, at least one embodiment of which includes a toroid-shaped device wound around a fixture such that portions of the device's length meet or overlap in the center of the toroid. This allows the outer portion of the device to form a scaffold while the interior portion of the device provides occlusion to prevent the influx of blood and promote thrombus formation.
[0007] One embodiment includes a strand of material that self-forms into a toroid-shaped series of loops and is designed to provide a stable structure within the body cavity, allowing for occlusion of the cavity and serving as a framework to hold additional treatment devices.
[0008] Another embodiment of the present invention provides a strand of material that self-forms into a cruciform series of loops and is designed to provide a stable structure within the body cavity, allowing for occlusion of the cavity and serving as a framework to hold additional treatment devices.
[0009] In another aspect, the invention includes tools and methods of manufacture to make the aforementioned embodiments of the invention.
[0010] In yet another aspect of the present invention, an embodiment includes a cruciform device wound around a fixture comprising at least two parallel pins disposed at an angle to at least one additional pin. This construction allows the outer portion of the device to form a scaffold while the interior portion of the device provides occlusion to prevent the influx of blood and promote thrombus formation. This embodiment also advantageously resists rotating or tumbling during deployment.
Brief Description of the Drawings
[0011] FIG. 1 is a perspective view of an embodiment of a fixture and a complex coil of the present invention;
[0012] FIG. 2 is a perspective view of an embodiment of a complex coil of the present invention;
[0013] FIG. 3 is a perspective view of an embodiment of a fixture and a complex coil of the present invention;
[0014] FIG. 4 is a perspective view of a complex coil of the present invention;
[0015] FIGS. 5-8 are photographs of a complex coils around various fixtures of the present invention;
[0016] FIGS. 9-10 are photographs of complex coils formed according to one of the methods of the present invention;
[0017] FIG. 11 is a perspective view of an embodiment of a complex coil of the present invention formed around an embodiment of a fixture of the present invention shown in phantom lines;
[0018] FIG. 12 is a perspective view of an embodiment of a complex coil of the present invention;
[0019] FIG. 13 is a perspective view of an embodiment of a complex coil of the present invention;
[0020] FIG. 14 is a perspective view of an embodiment of a fixture of the present invention;
[0021] FIG. 15 is a front elevation of the fixture shown in FIG. 14 ; and,
[0022] FIGS. 16-19 are photographs of several complex coils formed using methods and fixtures according to the present invention.
Detailed Description of the Invention
[0023] Toroid Three-Dimensional Coil
[0024] Referring now to the figures and first to FIGS. 1-6 , a coil or complex coil 10 is described that is shaped using a toroid-shaped fixture 12. The coil 10 has been wrapped around the fixture 12 four times in FIG. 1 such that four loops 14 are formed, each loop being positioned approximately 90 degrees from the adjacent loops. Wrapping the coil 10 around the fixture 12 causes the coil 10 to form into a complex shape when deployed into a body cavity such as a blood vessel or aneurysm. The device may be made from a length of wire that has been helically wound to form an elongate coil wire. Alternatively, the wire may be braided or knitted by methods known in the art to form a secondary shape. The wire is preferably a memory metal, such as Nitinol, but may be platinum, tantalum, tungsten, stainless steel, or other biocompatible material. Other materials, such as Dacron or Nylon fibers, biodegradable polymers such as polylactic or polyglycolic acid, and expansible or non-expansible hydrogel materials may be placed inside or outside the coil or braid structure to enhance the performance of the device.
[0025] For purposes of description only, an observation may be made regarding the shape of the complex coil 10 that results from wrapping the coiled wire around the toroid-shaped fixture 12. As illustrated in FIG. 2 , each of the loops 14a-d is roughly contained within respective planes 16a-d. The planes intersect with each other at approximately a common intersection axis 18 near the center of the complex coil 10. As one skilled in the art will realize, any loops formed around the toroid fixture 12 will only approximately be contained within such planes and the degree to which they are contained within these planes is only a function of how they are wound around the toroid and has little or no effect on their performance.
[0026] As shown in FIGS. 3 and 4 , any number of loops may be used in forming a complex coil of the present invention. In FIG. 3 , a complex coil 20 is formed by wrapping eight loops 22 around the toroid-shaped fixture 12. The loops 22 are relatively evenly spaced around the toroid 12 but may be spaced in any number of configurations. The result is the eight-looped complex coil 20 shown in FIG. 4 .
[0027] FIGS. 5 and 6 show complex coils 30 being formed around a toroid fixture 12 using 16 loops 32. The loops 32 are grouped in sets of two such that only eight distinct loops appear.
[0028] One example used to treat conditions, such as cerebral aneurysms, includes a platinum/tungsten alloy complex coil (92% Pt, 8% W available from Sigmund Cohn Mount Vernon, N.Y.) with a diameter in the range of about 0.125 mm to about 0.625 mm and a length of about 5 mm to about 1000 mm. The complex coil is formed around a ceramic or metallic toroid-shaped fixture similar to the fixtures 12 shown in FIGS. 1, 3, 5, and 6 . The winding pattern shown in FIGS. 1-6 forms a first loop 14a around the toroid 12, then a second loop 14b approximately 180° around the toroid from the first loop. In this example, a FIG. 8 pattern is used to wind the first and second loops. A third loop 14c is then formed at an angle around the center of the toroid, typically 5° to 175°, to the second loop. A fourth loop 14d is formed using a FIG. 8 pattern from the third loop 14c. More loops 14 may be added depending on the desired device size.
[0029] Those skilled in the art will appreciate that one advantage to the toroid complex coil configuration is that it may be scaled to the size of the treatment site by changing the number of loops. For example, very small (0.5-3 mm) lesions may be treated with 2 to 4 loop configurations, medium sized (4-10 mm) with 4-12 loop configurations, large (over 10 mm) with 8-36 loop configurations, and so on. The loops can form a closed structure such as an “O” shape (e.g. circle, oval, square, ellipse, star, etc.) or can be open such as a “C” or “U” shape. The loops may be of any dimension and are typically scaled to the approximate size of the treatment site. In the previous example, the loops may range from 0.5 mm diameter to 50 mm diameter. In this regard, “diameter” should not be narrowly construed to imply a circular dimension. Rather, “diameter” is used broadly to encompass the approximate size and shape of a loop.
[0030] After winding, the fixture and complex coil are heat-set by methods known in the art. For example, a typical annealing step for platinum complex coils is approximately 1100° F. for 5-40 minutes.
[0031] Once annealed, the complex coil will approximately retain the wound shape when substantially unconstrained or in its minimum energy state. The complex coil may then be subject to further processing such as forming a tip, adding a coupling mechanism for attachment to a delivery system, placing hydrogel or fibers onto or within the complex coil, placing a stretch resistant member inside or outside the complex coil, etc. The complex coil can then be attached to a delivery system, which is well known in the art, such as those disclosed in U.S. patent application Ser. No. 11/212,830, entitled Thermal Detachment System for Implantable Devices, the entirety of which is incorporated by reference hererin. Other examples of delivery systems are disclosed in Guglielmi U.S. Pat. No. 6,010,498 or Gandhi U.S. Pat. No. 6,478,773. Once attached to the delivery pusher, the complex coil is placed in a substantially linear configuration within a tube for delivery to the treatment site.
[0032] In a typical procedure, the linear complex coil is fed through a conduit such as a microcatheter by advancing it through the conduit with the delivery pusher. Upon exiting the microcatheter, the complex coil then self-forms into a structure within the treatment site that approximates its annealed shape.
[0033] The fixture 12 used to create the implant is shown as a closed circular toroid. However, other non-circular shapes such as elliptical, square, and star-shaped patterns may be used. In addition, the toroid does not need to be a closed structure. In fact, it may be easier to wind if a gap is left within the structure so that tension can be kept on the complex coil by hanging a weight.
[0034] Cruciform Three-Dimensional Coil
[0035] Referring now to FIGS. 7-12 , the production of complex coils 40 are shown using a fixture 42 that includes a plurality of pins 44 arranged at right angles to each other. Like the embodiments shown in FIGS. 1-6 , the embodiments of the complex coils 40 formed using the fixture 42 in FIGS. 7-12 may be made from a length of wire that has been helically wound to form a coiled wire. Alternatively, the wire may be braided or knitted by methods known in the art to form a secondary shape. The wire may be platinum, tantalum, tungsten, stainless steel, Nitinol, or other biocompatible material. Other materials, such as Dacron or Nylon fibers, biodegradable polymers such as polylactic or polyglycolic acid, and expansible or non-expansible hydrogel materials may be placed inside or outside the complex coil or braid structure to enhance the performance of the device. By way of example only, one embodiment might be used to treat such conditions as cerebral aneurysms, employs a platinum/tungsten alloy complex coil 10 (92% PT, 8% W available from Sigmund Cohn Mount Vernon, N.Y.) with a diameter in the range of about 0.125 mm to about 0.625 mm and a length of about 5 mm to about 1000 mm.
[0036] The complex coil 40 is formed by wrapping a coiled wire around the fixture 42, as shown in FIGS. 7-8 . The fixture 42 is preferably a ceramic or metallic cruciform fixture and includes a plurality of pins 44 arranged at right angles to each other along axes x, y, and z. More specifically, the fixture 42 includes two pins 44x that are parallel to the x-axis, two pins 44y that are parallel to the y-axis, and two pins 44z that are parallel to the z-axis.
[0037] An example of a complex coil 40 that can be made using the fixture 42 of FIGS. 7-8 is shown in FIGS. 9-12 . The winding pattern in this embodiment, shown most clearly in FIGS. 11-12 , forms a first loop 46a around a first pin 44y1, then a second loop 46b around a second pin 44x1 that is disposed at an angle to the first pin 44y1. In this embodiment the angle between the loops 46a and 46b is approximately 45°-135°. A third loop 46c is then formed in approximately the same plane as the second loop 46b. In this example, the third loop 46c is formed around pin 44x2 in a FIG. 8 pattern with the second loop 46b. A fourth loop 46d is then formed at an angle with the third loop 46c. In this example, the fourth loop 46d is approximately 45°-135° to the third loop and is formed around pin 44y2 and is also approximately coplanar to the first loop 46a. A fifth loop 46e is then formed at an angle to the fourth loop 46d by wrapping the wire around pin 44x1 spaced apart from loop 46b, also formed around pin 44x1. A sixth loop 46f lies in approximately the same plane as the fifth loop 46e in a FIG. 8 pattern with the fifth loop 46e. The sixth loop 46f is formed by wrapping the wire around pin 44x2 spaced apart from loop 46c, which is also formed around pin 44x2. In this example, the fifth loop 46e and the sixth loop 46f are approximately concentric with the second loop 46b and the third loop 46c, respectively.
[0038] Fewer than six loops may be used to form shorter complex coils, while additional loops may be wound to make a longer device. For example, the pins 44z shown in FIGS. 7-8 extend through the pins 44x and 44y and are thus being used to hold the pins 44x and 44y in place. However, if a longer device is desired, loops could be formed by wrapping wire around the portions of the pins 44z extending from the pins 44y.
[0039] Furthermore, those skilled in the art will appreciate that the same final result could be obtained by reversing the just-described winding pattern: i.e. winding a first loop around a first pin, winding a second loop in approximately the same plane as the first loop, winding a third loop at an angle to the second loop, winding a fourth loop at an angle to the third loop, winding a fifth loop in approximately the same plane as the fourth loop, winding a sixth loop at an angle to the fifth loop, and so on.
[0040] The loops can form a closed structure such as an “0” shape (e.g. circle, oval, square, ellipse, star, etc.) or can be open such as a “C” or “U” shape. The loops may be of any dimension and are typically scaled to the approximate size of the treatment site. In the previous example, the loops may range from 0.5 mm diameter to 50 mm diameter. In this regard, “diameter” should not be narrowly construed to imply a circular dimension. Rather, diameter is used broadly to encompass the approximate size and shape of a loop.
[0041] For example, the coil 50 shown in FIG. 13 has loops 52 that are open and closed. The open loops are formed by wrapping a wire around a pin but transitioning to an adjacent pin prior to completing an overlapping loop. More specifically, the complex coil 50 of FIG. 13 has six loops 52a-f formed using the fixture 42 of FIGS. 7 and 8 . Loop 52a is a complete loop formed around one of the pins 44y. The wire is then wrapped in a FIG. 8 pattern around two adjacent pins 44x to form open loops 52b and 52c. The wire is next wrapped completely around the other y pin, 44y to form complete loop 52d. Next, the wire is wrapped in a FIG. 8 pattern around the two pins 44y on the opposite side of pins 44x to form loops 52e and 52f. The loop 52e is open but the loop 52f is closed, being the last loop.
[0042] Further complexity may be introduced using the fixture 60 shown in FIGS. 14-15 . The fixture 60 in FIGS. 14-15 also has a plurality of pins 62 but differs from the fixture 42 in FIGS. 7 and 8 in three substantive ways. First, the pins 62 extend in directions parallel with x- and y-axes, but there are no pins that extend parallel to a z-axis. Rather, rectangular blocks 64 extend along the z-axis. Second, there are only two concentric pins, 62x1 and 62x2 that extend parallel to the x-axis. Third, there are four pins 62y1-4, each having independent longitudinal axes. Winding using the fixture 60 results in complex coils 70 such as those shown in FIGS. 16-19 . These figures show a complex coil 70 with first and second loops, 74a and 74b, that are substantially coplanar and arranged in a FIG. 8 pattern, as well as third and forth loops, 74c and 74d that are similarly substantially coplanar and arranged in a FIG. 8 pattern that is rotated from the FIG. 8 pattern of the first and second loops, 74a and 74b. The examples shown in FIGS. 16-19 show the two FIG. 8 patterns rotated 90 degrees relative to each other. Additionally, the complex coils 70 include fifth and sixth loops, 74e and 74f, which are relatively concentric.
[0043] After winding, the fixture and complex coil are heat-set by methods known in the art. For example, a typical annealing step for platinum complex coils is approximately 1100° F. for 5-60 minutes.
[0044] Once annealed, the complex coil will approximately retain the wound shape when substantially in a minimal energy state. The complex coil may then be subject to further processing such as forming a tip, adding a coupling mechanism for attachment to a delivery system, placing hydrogel or fibers onto or within the complex coil, placing a stretch resistant member inside or outside the complex coil, etc. The complex coil can then be attached to a delivery system, which is well known in the art, such as those disclosed in U.S. patent application Ser. No. 11/212,830, entitled Thermal Detachment System for Implantable Devices, the entirety of which is incorporated by reference hererin. Other examples of delivery systems are disclosed in Guglielmi U.S. Pat. No. 6,010,498 or Gandhi U.S. Pat. No. 6,478,773. Once attached to the delivery pusher, the complex coil 10 is placed in a substantially linear configuration within a tube for delivery to the treatment site.
[0045] In the typical procedure, the linear complex coil is fed through a conduit such as a microcatheter by advancing it through the conduit with the delivery pusher. Upon exiting the microcatheter, the complex coil then self-forms into a structure within the treatment site that approximates its annealed shape.
[0046] Although the invention has been described in terms of particular embodiments and applications, one of ordinary skill in the art, in light of this teaching, can generate additional embodiments and modifications without departing from the spirit of or exceeding the scope of the claimed invention. Accordingly, it is to be understood that the drawings and descriptions herein are proffered by way of example to facilitate comprehension of the invention and should not be construed to limit the scope thereof.
Claims
We claim:
1. A complex coil for occluding an aneurysm in a patient, comprising;
a microcoil comprised of a single filament, said single filament annealed to form a toroidal shape in an unconstrained state, said single filament being movable into a linear state for placement in a linear tube of a delivery device;
said single filament configured for advancement linearly out of said delivery device and into said cerebral aneurysm, and a proximal end of said single filament being detachable from said delivery device;
wherein, in said unconstrained state, said single filament self-forms into its annealed toroidal shape wherein a plurality of loops are each substantially contained within one of a plurality of planes that intersect each other at a common intersection axis near a center of said complex coil;
said plurality of loops arranged in a generally circular pattern about said common intersection axis so as to form said toroidal shape.
2. The complex coil of claim 1, wherein each of said plurality of loops is positioned at about 90 degrees from adjacent loops.
3. The complex coil of claim 1, wherein said plurality of loops further comprises several groups of two adjacent loops.
4. The complex coil of claim 1, wherein said toroidal shape is a closed shape.
5. The complex coil of claim 1, wherein said toroidal shape is an open shape.
6. A complex coil for occluding aneurysm in a patient, comprising;
a microcoil comprised of a single filament, said single filament annealed to form a toroidal shape in an unconstrained state, said single filament being movable into a linear state for placement in a linear tube of a delivery device;
said single filament configured for advancement linearly out of said delivery device and into said cerebral aneurysm, and a proximal end of said single filament being detachable form said delivery device;
wherein said single filament has a substantially linear configuration within said vascular delivery device and, when in an unconstrained condition, self-forming into its annealed shape having a plurality of loops each contained within planes that intersect with each other at a common intersection axis and are further located in a circular arrangement around said common intersection axis.
7. The complex coil of claim 6, wherein each of said plurality of loops is substantially evenly spaced in a toroid shape.
8. The complex coil of claim 6, wherein said plurality of loops form an open toroid shape.
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