US 9,408,539 B2Grant
Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
Issue Date:2016-08-09
•17 Claims
•27 Drawing Sheets
Abstract
Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.
Metadata
Assignees
- The General Hospital Corporation
- THE REGENTS OF THE UNIVERSITY OF COLORADO
Inventors
- Guillermo J. Tearney
- Brett E. Bouma
- Joseph A. Gardecki
- Linbo Liu
- Robert R. Mcleod
Application Information
Application Number:US 14/640,998
Filing Date:2015-03-06
Priority Date:2010-03-05
Art Unit:2883
Classifications
IPC:
G02B6/32A61B5/00G01B9/02
Field of Search:
G02B 6/32A61B 5/0084A61B 5/0066A61B 5/0075A61B 5/0044
Patent Drawings (27 sheets)
Description
Cross-Reference to Related Application(s)
[0001] This application is a continuation application based upon U.S. Continuation patent application Ser. No. 13/042,116 filed on Mar. 7, 2011 issued as U.S. Pat. No. 9,081,148 on Jul. 14, 2015, which claims the benefit of priority from U.S. patent application Ser. Nos. 61/311,171 and 61/311,272, both filed Mar. 5, 2010, the entire disclosures of which are incorporated herein by reference.
Field of the Disclosure
[0002] The present disclosure relates to exemplary embodiments of imaging systems, apparatus and methods, and more specifically to methods, systems and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution.
Background Information
[0003] Coronary artery disease (CAD) and its clinical manifestations, including heart attack or acute myocardial infarction (AMI), is the number one cause of mortality in the US, claiming nearly 500,000 lives and costing approximately $400 B per year. Topics relevant to the pathophysiology of CAD, such as the development and progression of coronary atherosclerotic lesions, plaque rupture and coronary thrombosis, and the arterial response to coronary device and pharmacologic therapies are therefore of great significance today. These biological processes can be mediated by molecular and cellular events that occur on a microscopic scale. Certain progress in understanding, diagnosing, and treating CAD has been hindered by the fact that it has been difficult or impossible to interrogate the human coronary wall at cellular-level resolution in vivo.
[0004] Over the past decade, intracoronary optical coherence tomography (OCT) has been developed, which is a catheter-based technique that obtains cross-sectional images of reflected light from the coronary wall. Intracoronary OCT has a spatial resolution of 10 μm, which is an order of magnitude better than that of the preceding coronary imaging method, intravascular ultrasound (IVUS). In the parent R01, a second-generation form of OCT has been developed, i.e., termed optical frequency domain imaging (OFDI), that has very high image acquisition rates, making it possible to conduct high-resolution, three-dimensional imaging of the coronary vessels. In addition, a flushing method has been developed which, in combination with the high frame rate of OFDI, can overcome at least some of the obstacles of blood interference with the OCT signal. As a direct result, it may be preferable to perform intracoronary OCT procedures in the clinical setting. Indeed, certain interventional cardiology applications for OCT have emerged, and growing the field exponentially. It is believed that OCT can become a significant imaging modality for guiding coronary interventions worldwide.
[0005] Since the technology developed in the parent ROl has been translated and facilitated for a clinical practice through the distribution of commercial OFDI imaging systems, it may be preferable to review macromolecules and cells involved in the pathogenesis of CAD.
[0006] For example, a transverse resolution in OCT procedure(s) can be determined by the catheter's focal spot size. To improve the resolution, it is possible to increase the numerical aperture of the lens that focuses light into the sample. This conventional method, however, neglects the intrinsic compromise between transverse resolution and depth of field in cross-sectional OCT images and results in images in which only a narrow depth range is resolved.
[0007] An alternative approach can exploit the unique characteristics of Bessel, or “non-diffracting” beams to produce high transverse resolution over enhanced depths-of-field. Bessel beam illumination and detection of light reflected from the sample, however, can suffer from a significant reduction in contrast and detection efficiency. Thus, there may be a need to overcome at least some of the deficiencies associated with the conventional arrangements and methods described above.
[0008] As briefly indicated herein above, certain exemplary embodiments of the present disclosure can be associated and/or utilize analysis and manipulation of a coherent transfer function (CTF) of an exemplary OCT system. The current invention is instead based on an analysis and manipulation of the coherent transfer function (CTF) of an OCT system. The CTF can be considered a coherent extension of a modulation transfer function (MTF) and an optical transfer function (OTF). Thus, for example, for non-interferometric systems, the MTF or OTF can be manipulated and utilized according to certain exemplary embodiments. In general, the quality of an optical system can be assessed by comparing its transfer function to that of a diffraction-limited optical system. FIG. 1 shows a graph of coherent transfer functions (CTFs) for, e.g., a diffraction limited 2.5 μm diameter spot and 2.5 μm spot with an extended focal range of 2.0 mm, produced by Bessel beam illumination and detection. As illustrated in FIG. 1 , the transfer function of a Bessel beam illumination and detection 100 can have spatial frequencies that exceed a diffraction-limited system 110, although it likely sacrifices low- and mid-range spatial frequencies, possibly resulting in reduced contrast and detection sensitivity.
[0009] Thus, there may be a need to overcome at least some of the deficiencies associated with the conventional arrangements and methods described above.
Summary of Exemplary Embodiments of the Disclosure
[0010] To address and/or overcome such deficiencies, one of the objects of the present disclosure is to provide exemplary embodiments of systems, methods and computer-accessible medium according to the present disclosure, which can provide microscopic images of at least one anatomical structure at a particular resolution. Another object of the present disclosure is to overcome a limited depth of focus limitations of conventional Gaussian beam and spatial frequency loss of Bessel beam systems for OCT procedures and/or systems and other forms of extended focal depth imaging.
[0011] According to another exemplary embodiment of the present disclosure, more than two imaging channels can illuminate/detect different Bessel and/or Gaussian beams. In yet a further exemplary embodiment, different transfer functions can be illuminated and/or detected. The exemplary combination of images obtained with such additional exemplary beams can facilitate the μOCT CTF to be provided to the diffraction-limited case, and can also facilitate a depth-of-field extension even further.
[0012] Accordingly, exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.
[0013] In another exemplary embodiment of the present disclosure, the wave-guiding arrangements can provide the radiation(s) in at least partially a circular pattern. At least one lens arrangement can be included which is configured to receive the electro-magnetic radiation(s) from the wave-guiding arrangements, and generate a further focus-spot radiation. The lens arrangement(s) can be configured to cause the further focus-spot radiation to have (i) an extended focal depth, and/or (ii) a diameter that is smaller than a diffraction limited spot on or in the sample. The diffraction limited spot can be a three-dimensional spot. In addition or alternatively, The lens arrangement(s) can include a grin lens.
[0014] According to yet another exemplary embodiment of the present disclosure, at least one of the wave-guiding arrangements can be (i) a single-mode wave-guide, and/or (ii) composed a photo-polymer. Additionally, a further wave-guiding arrangement can be provided, which is configured to provide a further electro-magnetic radiation to the sample, where the electro-magnetic radiation(s) and the further electro-magnetic radiation can be provided to at least partially overlapping portions of the sample. A housing can also be provided which at least partially encloses the wave-guiding arrangements, and/or a sheath can be provided which encloses the housing. Further, a control arrangement can be provided which is configured to rotate and/or translate the housing. The lens arrangement(s) can include at least one optical element formed by and/or subjected to a photopolymer processing. The photopolymer processing can include irradiating a photopolymer so as to form the optical element(s).
[0015] In a further exemplary embodiment of the present disclosure, method and system can be provided for generating data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion(s) of the sample through at least one optical arrangement which is formed by or subjected to a photopolymer processing. At least one second radiation can be received from the portion(s) which can be based on the first radiation(s). Based on an interaction between the optical arrangement(s) and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Then, at least one third radiation can be forwarded to the portion(s) through the optical arrangement. At least one fourth radiation can be received from the portion(s) which can be based on the third radiation(s). Based on an interaction between the optical arrangement(s) and the third radiation and/or the fourth radiation, the optical arrangement(s) can have a second transfer function, where the first transfer function can be at least partially different from the second transfer function. Further, the data associated with the portion(s) can be generated based on the second and fourth radiations.
[0016] According to yet further exemplary embodiment of the present disclosure, method and system can be provided also for generating data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion(s) of the sample through at least one first optical arrangement which is formed by or subjected to a photopolymer processing. At least one second radiation can be received from the portion(s) which can be based on the first radiation(s). Based on an interaction between the first optical arrangement(s) and the first radiation and/or the second radiation, the first optical arrangement(s) can have a first transfer function. Then, at least one third radiation can be forwarded to the portion(s) through at least one second optical arrangement. At least one fourth radiation can be received from the portion(s) which can be based on the third radiation(s). Based on an interaction between the second optical arrangement(s) and the third radiation and/or the fourth radiation, the second optical arrangement(s) can have a second transfer function, where the first transfer function can be at least partially different from the second transfer function. Further, the data associated with the portion(s) can be generated based on the second and fourth radiations. The first optical arrangement(s) and/or the second optical arrangement(s) can be formed by or subjected to a photopolymer processing.
[0017] These and other objects, features and advantages of the exemplary embodiment of the present disclosure will become apparent upon reading the following detailed description of the exemplary embodiments of the present disclosure, when taken in conjunction with the appended claims.
Brief Description of the Drawing(s)
[0018] Further objects, features and advantages of the present invention will become apparent from the following detailed description taken in conjunction with the accompanying figures showing illustrative embodiments of the present disclosure, in which:
[0019] FIG. 1 is an exemplary graph of coherent transfer functions (CTFs) as a function of spatial frequencies produced by the prior Bessel beam illumination and detection;
[0020] FIG. 2 is an exemplary graph of coherent transfer functions (CTFs) as a function of spatial frequencies produced by an exemplary embodiment of a procedure and/or technique according to the present disclosure;
[0021] FIG. 3A is a first exemplary OCT image an exemplary OCT image of a cadaver coronary artery plaque obtained using an exemplary procedure/techniques according to an exemplary embodiment of the present disclosure, whereas an exemplary Gauss-Gauss image contains low spatial frequency information;
[0022] FIG. 3B is a second exemplary OCT image of the cadaver coronary artery plaque using an exemplary procedure/techniques according to an exemplary embodiment of the present disclosure, whereas an exemplary Bessel-Bessel image provides high-resolution but loses low and mid spatial frequencies;
[0023] FIG. 3C is a third exemplary OCT image of the cadaver coronary artery plaque using an exemplary procedure/techniques according to an exemplary embodiment of the present disclosure, which provides a combined μOCT image (e.g., Gauss-Gauss+Gauss-Bessel+Bessel-Bessel), and images are normalized and displayed with the same brightness/contrast values;
[0024] FIG. 4A is a side cut-away view of a diagram of distal optics of a OCT catheter system according to an exemplary embodiment of the present disclosure;
[0025] FIG. 4B is an exemplary graph of a polymer index profile generated using a Y-junction fan-out of the system the exemplary embodiment of shown in FIG. 4A ;
[0026] FIG. 4C is an exemplary graph of an illumination profile generated using the Y-junction fan-out of the system the exemplary embodiment of shown in FIG. 4A ;
[0027] FIG. 4D is an exemplary graph of an simulated x-z PSF using the Y-junction fan-out of the system the exemplary embodiment of shown in FIG. 4A ;
[0028] FIG. 5A is a side cut-away view of a diagram of the distal optics of a OCT catheter system according to another exemplary embodiment of the present disclosure;
[0029] FIG. 5B is an exemplary graph of an illumination profile generated using the distal optics con figuration of the system the exemplary embodiment of shown in FIG. 5A ;
[0030] FIG. 5C is an exemplary graph of simulated x-z PSF generated using the distal optics con figuration of the system the exemplary embodiment of shown in FIG. 5A ;
[0031] FIG. 6 is a schematic diagram of a system for generating one or more μOCT images according to still a further exemplary embodiment of the present disclosure;
[0032] FIG. 7 are side cut-away views of diagrams of the distal optics of the OCT catheter system according to still another exemplary embodiment of the present disclosure which includes axicon pair and a routing of a ring beam and a Gaussian beam of the distal optics configuration;
[0033] FIG. 8 is a side cut-away view of a diagram of the OCT catheter system according to yet further exemplary embodiment of the present disclosure which includes an exemplary optical pathlength incoding probe configuration that uses a single fiber and a single axicon lens;
[0034] FIG. 9 are side cut-away views of diagrams of the OCT catheter system according to a still further exemplary embodiment of the present disclosure which includes a further exemplary optical pathlength incoding probe configuration that uses a single fiber and a single axicon lens;
[0035] FIG. 10 are schematic views of diagrams of the distal optics of the OCT catheter system according to a further exemplary embodiment of the present disclosure which includes a single fiber multifocal lens probe configuration;
[0036] FIG. 11 is a side cut-away view of a diagram of the OCT catheter system according to a still further exemplary embodiment of the present disclosure which utilizes a mirror tunnel;
[0037] FIG. 12 is a side cut-away view of a diagram a portion of the OCT catheter system according to yet another exemplary embodiment of the present disclosure which utilizes a reflective achromatic phase mask and a ball lens;
[0038] FIG. 13 is a graph of a phase shift spectra of chromatic light upon reflection at glass-metal interface based on the exemplary embodiment of FIG. 12 ;
[0039] FIG. 14A is an illustration of a Huygens diffraction pattern of lens with conventional focusing;
[0040] FIG. 14B is an exemplary illustration of a Huygens diffraction pattern of lens with reflective achromatic phase mask and ball lens depicted in the exemplary embodiment of the system illustrated in FIG. 13 .
[0041] FIG. 15A is a schematic diagram of an exemplary embodiment of a focusing arrangement that uses a refractive achromatic phase doublet mask in accordance with an exemplary embodiment of the present disclosure;
[0042] FIG. 15B is an exemplary graph of transverse phase profiles of an exemplary mask illustrated in FIG. 15A ;
[0043] FIG. 16 is a schematic diagram of the OCT system which includes a wavefront beam splitter and a common path interferometer, according to yet another exemplary embodiment of the present disclosure;
[0044] FIG. 17A is an exemplary simulated PSF illustration of generated by the exemplary OCT system shown in FIG. 16 that uses a monochromatic light source (e.g., λ=825 nm) and a spherical aberration free objective lens;
[0045] FIG. 17B is an exemplary simulated PSF illustration of generated by the exemplary OCT system shown in FIG. 16 that uses a monochromatic light source (e.g., λ=825 nm) and an objective lens with a spherical aberration and a wavelength dependent focal shift;
[0046] FIG. 17C is an exemplary simulated PSF illustration of generated by the exemplary OCT system shown in FIG. 16 that uses a broadband source (e.g., about 600 nm to 1050 nm) and an objective lens with spherical aberration and a wavelength dependent focal shift;
[0047] FIG. 17D is an exemplary simulated PSF illustration of generated by the exemplary OCT system shown in FIG. 16 that uses broadband source (e.g., 600 nm to 1050 nm), an objective lens with spherical aberration and a wavelength dependent focal shift, and an wavefront beam splitter;
[0048] FIG. 18A is an exemplary μOCT image of a coronary plaque showing multiple leukocytes (arrows);
[0049] FIG. 18B is an exemplary μOCT image of a coronary plaque illustrating multiple leukocytes (arrows) of two different cell types, one smaller cell with scant cytoplasm, consistent with a lymphocyte (L) and another, larger cell with a highly scattering cytoplasm, indicative of a monocyte (M);
[0050] FIG. 18C is an exemplary μOCT image of a coronary plaque illustrating a cell with an indented, bean-shaped nucleus (M) characteristic of a monocyte;
[0051] FIG. 18D is an exemplary μOCT image of a coronary plaque illustrating a leukocyte with a multi-lobed nucleus, which can indicate a neutrophil (N) attached to the endothelial surface;
[0052] FIG. 18E is an exemplary μOCT image of the coronary plaque illustrating multiple leukocytes tethered to the endothelial surface by pseudopodia;
[0053] FIG. 18F is an exemplary μOCT image of the coronary plaque illustrating cells with the morphology of monocytes (M) in a cross-section and an inset transmigrating through the endothelium;
[0054] FIG. 18G is an exemplary μOCT image of multiple leukocytes distributed on the endothelial surface;
[0055] FIG. 19A is an exemplary μOCT image of platelets (P) adjacent to a leukocyte characteristic of a neutrophil (N), which is also attached to a small platelet;
[0056] FIG. 19B is an exemplary μOCT image of fibrin (F) which is visible as linear strands bridging a gap in the coronary artery wall;
[0057] FIG. 19C is an exemplary μOCT image of a cluster of leukocytes (L), adherent to the fibrin in an adjacent site to that illustrated in FIG. 19B ;
[0058] FIG. 19D is an exemplary μOCT image of Fibrin thrombus (T) with multiple, entrapped leukocytes;
[0059] FIG. 19E is an exemplary μOCT image of a more advanced thrombus (T) showing a leukocyte and fibrin strands;
[0060] FIG. 20A is a cross-sectional exemplary μOCT image of endothelial cells in culture;
[0061] FIG. 20B is an en face exemplary μOCT image of endothelial cells in culture;
[0062] FIG. 20C is an exemplary μOCT image of a native swine coronary artery cross-section;
[0063] FIG. 20D is an exemplary three-dimensional rendering of the swine coronary artery, demonstrating endothelial “pavementing”;
[0064] FIG. 21A is an exemplary μOCT image of microcalcifications which can be seen as bright densities within the μOCT image of the fibrous cap;
[0065] FIG. 21B is an exemplary μOCT image of the microcalcifications which can be seen as dark densities on the corresponding histology;
[0066] FIG. 22A is an exemplary μOCT image of a large calcium nodule, demonstrating disrupted intima/endothelium;
[0067] FIG. 22B is an expanded view of the region enclosed by a box illustrating microscopic tissue strands, consistent with fibrin (F), adjoining the unprotected calcium (white arrow) to the opposing detached intima;
[0068] FIG. 22C is an illustration of a corresponding histology of fibrin (F, black arrows) and denuded calcific surface (gray arrow);
[0069] FIG. 23A is an exemplary μOCT image of a large necrotic core (NC) fibroatheroma, demonstrating thick cholesterol crystals (CC), characterized by reflections from their top and bottom surfaces;
[0070] FIG. 23B is an exemplary μOCT image of thin crystal (CC, gray arrow) piercing the cap of another necrotic core plaque (NC), shown in more detail in the inset;
[0071] FIG. 24A is an exemplary μOCT image of various smooth muscle cells appearing as low backscattering spindle-shaped cells (inset);
[0072] FIG. 24B is an exemplary μOCT image of smooth muscle cells producing collagen are spindle shaped, have a high backscattering interior (light gray arrow) and a “halo” of low backscattering (white arrow), which represents the cell body and collagen matrix, respectively (histology inset);
[0073] FIG. 25A is an exemplary μOCT image of Taxus Liberte struts with/without polymer/drug, i.e., for polymer-coated struts, polymer reflection (PR), strut reflection (SR) and multiple reflections (MR1, MR2) can be seen;
[0074] FIG. 25B is an exemplary μOCT image of a cadaver coronary specimen with an implanted BMS shows struts devoid of polymer, covered by neointima;
[0075] FIG. 25C is an exemplary μOCT image of a cadaver coronary specimen with implanted DES struts from another cadaver showing polymer overlying the strut reflections (P, inset);
[0076] FIG. 26A is an exemplary μOCT image showing tissue (light gray arrow) has separated the polymer off of the stent strut and the polymer has fractured (white arrow);
[0077] FIG. 26B is an exemplary μOCT image illustrating a superficial leukocyte cluster (red arrow) and adjacent attached leukocytes overlying the site of the polymer fracture;
[0078] FIG. 26C is an exemplary μOCT image illustrating an inflammation at the edge of a strut (dashed region) from another patient;
[0079] FIG. 26D is an exemplary μOCT image illustrating an uncovered strut, completely devoid of overlying endothelium (inset);
[0080] FIG. 27A is a flow diagram of a process according to one exemplary embodiment of the present disclosure; and
[0081] FIG. 27B is a flow diagram of the process according to another exemplary embodiment of the present disclosure.
[0082] Throughout the figures, the same reference numerals and characters, unless otherwise stated, are used to denote like features, elements, components or portions of the illustrated embodiments. Moreover, while the subject disclosure will now be described in detail with reference to the figures, it is done so in connection with the illustrative embodiments. It is intended that changes and modifications can be made to the described exemplary embodiments without departing from the true scope and spirit of the subject disclosure as defined by the appended claims.
Detailed Description of Exemplary Embodiments
[0083] According to one exemplary embodiment of the present disclosure, two or more imaging channels can be utilized, e.g., at least one which providing the Bessel beam illumination or detection and at least another one of which providing a Gaussian beam illumination or detection. This exemplary configuration can facilitate three or more unique and separable illumination-detection combinations (e.g., Bessel-Bessel, Bessel-Gaussian, Gaussian-Gaussian, etc.), where each combination can correspond to a different OCT image. As shown in the exemplary graph of FIG. 2 , coherent transfer functions (CTFs) for 2.5 μm diameter spots are provided.
[0084] For example, FIG. 2 illustrates a graphical comparison of a diffraction limit 200, extended focal range of 0.15 mm used in preliminary data 210, and the exemplary results of an exemplary embodiment of a procedure or technique according to the present disclosure, hereinafter termed μOCT, with a focal range of 2.0 mm. According to one exemplary embodiment of the present disclosure the μOCT CTF can be generated, e.g., by combining Gaussian-Gaussian images 220, Bessel-Gaussian images 230, and Bessel-Bessel images 240.
[0085] In another exemplary embodiment of the present disclosure, the exemplary μOCT CTF procedure/technique can be used and/or provided over an axial focus range that can be, e.g., more than 0.5 mm, 1 mm, 2 mm, etc. (as well as others). According to additional exemplary embodiments of the present disclosure, the transverse FWHM spot diameters can be less than 5 μm, 2 μm, 1 μm, etc. (as well as others). In still further exemplary embodiments of the present disclosure, the depth of focus can be extended a factor of, e.g., approximately 2, 5, 10, 20, 50, 100, etc. (and possibly more) compared to the illumination with a plane wave or Gaussian beam. In yet another exemplary embodiment of the present disclosure, the high, low, and medium spatial frequency content in the image can be at least partially restored by combining images with different transfer functions.
[0086] FIGS. 3A-3C show exemplary OCT images of a cadaver coronary artery plaque obtained using an exemplary procedure/techniques according to exemplary embodiments of the present disclosure. For example, in FIG. 3A an exemplary Gauss-Gauss image contains low spatial frequency information. In FIG. 3B , an exemplary Bessel-Bessel image provides high-resolution but loses low and mid spatial frequencies. Further, in FIG. 3C , a combined μOCT image (e.g., Gauss-Gauss+Gauss-Bessel+Bessel-Bessel) is provided, and images are normalized and displayed with the same brightness/contrast values.
[0087] FIG. 4A shows a side cut-away view of a diagram of a system which includes distal optics of a OCT catheter according to a first exemplary embodiment of the present disclosure. This exemplary system includes a Y-junction fan-out to produce the annulus (e.g., a darker shade in FIG. 4A ) and the Gaussian beam (e.g., a lighter shade in FIG. 4A ) of an exemplary distal optics design and/or configuration. This exemplary system of FIG. 4A is provided to generate a diffraction-limited CTF and an axial focus range (e.g., a depth-of-focus) that can be more than, e.g., about 10 times longer than the diffraction-limited depth-of-focus. As shown in FIG. 4A , an exemplary output of a waveguide 400 can be transformed by a y-junction fan-out element 410 to an array of spots that subtend a pattern such as a circle (as shown in an illustration of FIG. 4C ). The index profile of this element (as shown in an exemplary graph of FIG. 4B ) can be configured to be lossless and achromatic. The output of each spot can be individually collimated by a beam collimator in a collimator array 420.
[0088] As show in FIG. 4A , a Gaussian beam can be routed through a separate waveguide 430 in the center of the annular array. The exemplary output of the waveguide can be collimated by a collimator 440 located in the center of the collimator array 420. Exemplary collimated annular and Gaussian beams can be focused onto the sample using, e.g., one or more lenses, including but not limited to a gradient index (GRIN) lens 450, as shown in FIG. 4A . In addition to focusing two beams, such exemplary GRIN lens(es) 450 can be configured and/or structured to intentionally generate chromatic aberration, which can extend the axial focus yet further (as shown in an illustration of FIG. 4D ), and to possibly compensate for the aberrations induced by a transparent outer sheath 460. Electro-magnetic radiation (e.g., light) can be directed to an anatomical structure 480 by a deflector 470.
[0089] FIG. 5A shows a second exemplary embodiment of distal optics of a OCT catheter system according to the present disclosure. For example, the exemplary system of FIG. 5A illustrates an axicon arrangement (e.g., pair) and a routing of the annulus (shown in a darker shade in FIG. 5A ) and the Gaussian beam (shown in a lighter shade in FIG. 5A ) of the distal optics design according to this exemplary embodiment. In particular, the exemplary system illustrate din FIG. 5A can generate a diffraction-limited CTF and an axial focus range (e.g., depth-of-focus) that can be more than, e.g., 10 times longer than the diffraction-limited depth-of-focus. The output of a waveguide 500 can be collimated by a collimator 510 located in a center of the exemplary catheter system. The collimated electro-magnetic radiation (e.g., light) can be transformed into an annular beam using two or more axicons 520, 530. According to another exemplary embodiment, the axicons can be generated or produced using gradient index.
[0090] As shown in FIG. 5A , a separate waveguide 540 can be routed through the center of the annulus. The output of the waveguide can be collimated by a collimator 550 located in the center of the annulus. Simulated transverse intensity profiles of the collimated annular and Gaussian beams are shown in an illustration of FIG. 5B . Collimated annular and Gaussian beams can be focused onto the sample using one or more lens, such as a GRIN lens 560. In addition to focusing two or more beams, the GRIN lens 560 can be configured to intentionally generate chromatic aberration, which can extend the axial focus further (as shown in an illustration of FIG. 5C ), and to compensate the aberrations induced by the transparent outer sheath 570. The electro-magnetic radiation (e.g., light) can be directed to the artery wall by a deflector 580.
[0091] FIG. 6 shows a schematic diagram of an imaging system for generating μOCT images according to an exemplary embodiment of the present disclosure. As provided in the exemplary embodiment of FIG. 6 , an output of a source 600 providing electro-magnetic radiation(s) (e.g., light radiation) can be linearly polarized by a linear polarizer 602, and split into two or more beams by a beam splitter 604. At least one of the beams can be redirected to an input port of a switch 606.
[0092] At least one of outputs of the switch 606 can be transmitted through a beam splitter 610, and coupled into a first light/electro-magnetic radiation guide 612. Another other of the outputs of the switch 606 can be attenuated by an attenuator 614, guided by a second light/electro-magnetic radiation guide 616 to a third beam splitter 618, and redirected to a reference reflector 620 through an attenuator 622, a third light/electro-magnetic radiation guide 624 and a dispersion compensation arrangement 626. An output of the light guide 612 can be connected to Bessel illumination and Bessel detection channel of a catheter 628.
[0093] As shown in FIG. 6 , a further one of the outputs of the beam splitter 604 can be redirected to input port of a second three-port switch 630. One of the outputs of the switch 630 can be transmitted through a beam splitter 632, and coupled into a fourth light/electro-magnetic radiation guide 634. Another one of the outputs of the switch 630 can be attenuated by an attenuator 635 guided by a fifth light guide 636 to a fourth beam splitter 638, and redirected to a reference reflector 640 through an attenuator 642, a fifth light guide 644 and a second dispersion compensation arrangement 646. The output of the light guide 634 can be connected to a Gaussian illumination and Gaussian detection channel of the catheter 628.
[0094] When the state of the switch 606 is 1, and the state of switch 630 is 2, e.g., only the light/electro-magnetic radiation guide 612 can be illuminated so that the sample is illuminated by the Bessel illumination channel (see Table 1 of FIG. 6 ). The back-scattered light from the sample can picked up by both, some or all of the Bessel and Gaussian detection channels of the catheter 628 (see Table 1 of FIG. 6 ). The portion of electro-magnetic radiation/light picked up by the Bessel detection channel can be guided by the first electro-magnetic radiation/light guide 612 to the beam splitter 610, where such radiation/light can be combined and interfered with the light from the reference reflector 620.
[0095] Further, as illustrated in FIG. 6 , at least part of the interference signal can be directed by the beam splitter 610 to a pinhole 648. An output of the pinhole 648 can be collimated and split by a polarizing beam splitter 650. One of outputs of the polarizing beam splitters 650 can be transmitted through a half wave plate 652, and detected by a spectrometer 654. Another of the outputs of the polarizing beam splitters 650 can be detected by a second spectrometer 656. A portion of the electro-magnetic radiation/light picked up by the Gaussian detection channel can be guided by the light guide 634 to the beam splitter 632, where it is combined and interfered with the light from the reference reflector 640. At least part of the interference signal can be directed by the beam splitter 632 to a pinhole 658. An output of the pinhole 658 can be collimated and split by a polarizing beam splitter 660. At least one of outputs of the polarizing beam splitters 660 can be transmitted through a half wave plate 662, and detected by a third spectrometer 664. Another of the outputs of the polarizing beam splitters 660 can be detected by a fourth spectrometer 666.
[0096] When the state of the switch 606 is 2 and the state of the switch 630 is 1, e.g., only the fourth electro-magnetic radiation/light guide 634 can be illuminated, so that the sample is illuminated by Gaussian illumination channel (shown in Table 1 of FIG. 6 ). The back-scattered electro-magnetic radiation/light from the sample can be picked up by both Bessel and Gaussian detection channels of the catheter 628 (shown in Table 1 of FIG. 6 ). At least one portion of the electro-magnetic radiation/light picked up by the Bessel detection channel is guided by the electro-magnetic radiation/light guide 612 to the beam splitter 610, where it can be combined and interfered with the light from the reference reflector 620. At least part of the interference signal can be directed by the beam splitter 610 to a pinhole 648. An output of the pinhole 648 can be collimated and split by a polarizing beam splitter 650. At least one of outputs of the polarizing beam splitters 650 can be transmitted through a half wave plate 652, and detected by a spectrometer 654. Another of the outputs of the polarizing beam splitters 650 can be detected by a second spectrometer 656.
[0097] The portion of light picked up by the Gaussian detection channel is guided by the electro-magnetic radiation/light guide 634 to the beam splitter 632, where it is combined and interfere with the light/radiation from the reference reflector 640. At least part of the interference signal can be directed by the beam splitter 632 to a pinhole 658. The output of pinhole 658 is collimated and split by a polarizing beam splitter 660. AT least one of the two outputs of the polarizing beam splitters 660 can be transmitted through a half wave plate 662, and detected by a third spectrometer 664. Another of the outputs of the polarizing beam splitters 660 can be detected by a fourth spectrometer 666.
[0098] Such exemplary polarization-diverse detection scheme/configuration shown in FIG. 6 implemented by the combination of the polarizing beam splitter 650, the half wave plate 652 and the spectrometers 654, 656, and/or a combination of the polarizing beam splitter 660, the half wave plate 662 and the spectrometers 664, 666 can reduce and/or eliminate artifacts associated with tissue or optical fiber birefringence. The exemplary embodiment of the μOCT catheter system according the present disclosure illustrated in FIG. 6 can contain multiple waveguides that can, e.g., independently transmit and/or receive light/radiation from the catheter to waveguides 612 and 632. The detected signal can be digitized and transferred by a computer 668 via an image acquisition board 670. Data can be digitally displayed on or via a monitor 672, and/or stored in a storage device 674.
[0099] According the present disclosure, the μOCT detection technology can be implemented using, in one exemplary embodiment, a time domain OCT (TD-OCT) system, in another exemplary embodiment, a spectral-domain (SD-OCT) system, and, in yet another exemplary embodiment, an optical frequency domain interferometry (OFDI) system. Complex images and/or real images from the different transfer function illumination and detection configurations can be acquired using the exemplary embodiment of the imaging system according to the present disclosure. In one exemplary embodiment, such exemplary images can be filtered and recombined to generate a new image with an improved quality and a CTF that more closely approximates the diffraction limited CTF. The exemplary images with different transfer functions can be filtered or recombined incoherently and/or coherently to generate a new image with a CTF procedure/technique that more closely approximates the diffraction limited CTF procedure/technique.
[0100] FIG. 7 shows another exemplary embodiment of distal optics configuration of a OCT catheter according to the present disclosure for generating a diffraction-limited CTF and an axial focus range (e.g., depth-of-focus) that can be more than, e.g., approximately 10 times longer than the diffraction-limited depth-of-focus.
[0101] For example, an output of a waveguide 700 can be collimated by a collimator 710. Indeed, the waveguide 700 can be routed through the annular beam and is collimated Gaussian beam will be routed through the center of the annulus. The collimated light can be transformed into an annular beam through two or more axicons, such as, e.g., GRIN axicons 720, 730. A separate waveguide 740 can be routed through a center of the annulus. An output of the waveguide 740 can be collimated by a collimator 750 located in the center of the annulus. The collimated annular and Gaussian beams can be focused onto the sample using one or more lens(es) 760, which can be, e.g., one or more GRIN lenses. In addition to focusing the beams, the GRIN lens 760 can be configured and/or structured to intentionally generate chromatic aberration(s), which can extend the axial focus further and compensate for the aberrations induced by a transparent outer sheath. The light/radiation can be directed to the artery wall by a deflector 770.
[0102] FIG. 8 shows another exemplary embodiment of the distal optics configuration of the OCT catheter according to the present disclosure. Such exemplary configuration can be used to generate a diffraction-limited CTF and depth of focus that is, e.g., more than 10 times longer than the diffraction-limited depth-of-focus. An output of a waveguide 800 can be collimated by a collimator 810. A pupil aperture created by the collimator 810 can be split into two or more beams, i.e., central circular beam(s) and an annular beam. One or more lenses 820, such as an objective lens, achromat lens, aplanat lens, or GRIN lens, that has an aperture substantially the similar as or identical to a central zone can focus a low NA Gaussian beam into the tissue or the sample.
[0103] The annular beam can be transmitted through a spacer 830, and focused into the sample by an annular axicon lens 840 with an aperture that is substantially similar or identical to the annular beam. The beams can be directed to the sample by a deflector 850. There can be four images generated from four channels, e.g., central illumination/central detection, central illumination/annular detection, annular illumination/annular detection, annular illumination/central detection. The optical pathlength of the lens 820 can be configured to be different from that of the spacer 830 so that each of, e.g., four images generated can be pathlength encoded. In this exemplary embodiment, the different images can be detected, and their CTF can be combined as per the exemplary methods and/or procedures described herein.
[0104] FIG. 9 shows another exemplary embodiment of the distal optics configuration of the OCT catheter system according to the present disclosure, which can be used for generating a diffraction-limited CTF and a depth of focus that is longer than the diffraction-limited depth-of-focus. For example, as illustrated in FIG. 9 , the output of a waveguide 900 can be collimated by a collimator 910. A pupil aperture created by the collimator 910 can be split into two or more zones by a circular glass window 920 positioned at the center of the objective lens aperture, e.g., (i) a central circular zone that is transmitted through the circular glass window 920, and (ii) an annular zone. The central circular beam can be focused as a low NA Gaussian beam into the tissue and/or sample, and the annular beam can be focused into a Bessel beam focus in the tissue by the lens 930. A glass window can have a higher refractive index than air, and the thickness of the window can be so chosen such that the light/radiation field that undergoes different channel can be path-length separated and/or encoded. In each A line, there can be three or more segments of signal coming from the (e.g., 4) channels: central illumination/central detection, central illumination/annular detection, annular illumination/annular detection, annular illumination/central detection.
[0105] FIG. 10 shows a further exemplary embodiment of the distal optics configuration of the OCT catheter system for generating a diffraction-limited CTF and a depth of focus that can be longer than the diffraction-limited depth-of-focus. An output of a waveguide 1000 can be collimated by a collimator 1010. A pupil aperture created by the collimator 1010 can be split into a number of concentric zones 1020, 1030, 1040. A multifocal lens, such as, e.g., a GRIN lens, can be used so that the beam in each zone can be focused to a different axial focal position. The scattered light/radiation from each zone can be optical pathlength-encoded so that such scattered beams do not interfere with each other. In this exemplary embodiment, the different images can be detected, and their CTF combined pursuant to the exemplary methods and procedures described herein.
[0106] FIG. 11 shows yet another exemplary embodiment of the distal optics configuration of the OCT catheter system for generating a diffraction-limited CTF and an axial focus range (e.g., depth-of-focus) that is longer than the diffraction-limited depth-of-focus. For example, an output of a point object 1100 can be transformed by a mirror tunnel device 1110 to multiple orders of light/radiation beams, e.g., zeroth order beam 1120, −1st order beam 1130, and −2nd order beam 1140, etc. When a focusing device 1150 is employed so that most or all the order of rays are focused at the same focal position in the sample, each order of rays can contain a unique band of spatial frequency of the illumination/detection CTF of the focusing device. These orders can, in yet another exemplary embodiment, be path length-encoded so that images generated therein can be detected, and their CTF combined using the different images corresponding to the different orders as per the exemplary CTF combination methods and/or procedures described herein.
[0107] FIG. 12 shows another exemplary embodiment of the distal optics configuration of the OCT catheter system according to the present disclosure for generating a diffraction-limited CTF and a depth of focus that is longer than the diffraction-limited depth-of-focus. As illustrated in FIG. 12 , an output of a waveguide 1200 can be focused by a half ball lens 1210. A planar surface of the half ball lens 1210 can have a binary phase pattern 1220. In one further exemplary embodiment, the depth of the pattern can be configured to produce a small phase shift, e.g., such as a pattern depth of 198 nm (π phase shift at 850 nm). In another exemplary embodiment, the top surface can be coated with a reflecting coating, such as Au, and a bottom surface can be coated with the same and/or another coating such as Al, with the final phase shift being given by a curve 1300 shown in a graph of FIG. 13 , which illustrates an optical phase length difference of the glass mask (e.g., no metal coating) and a total phase shift (e.g., mask+coating).
[0108] A curve 1310 and a curve 1320 of the graph of FIG. 13 can have a wavelength-dependent phase change of the p-polarized light upon reflection at BK7-Al and BK7-Au, respectively, with an incident angle of 45 degrees. The curve 1330 can be the wavelength dependent phase shift of the light caused by, e.g., 198 nm height difference upon 45 degree reflection at BK7-air interface. A binary phase mask can be optimized to produce an extended axial focus (as shown in an illustration of FIG. 14b ) compared with the diffraction limited axial focus (as shown in an illustration of FIG. 14a ). The light/radiation transmitted from the surfaces with different phase shifts can generate different transfer functions, which can be detected and combined to create a new image with a different CTF pursuant to the exemplary methods and/or procedures described herein.
[0109] FIG. 15A shows a side-cut-away view of a diagram of another exemplary embodiment of the distal optics configuration of the OCT catheter system for generating a diffraction-limited CTF and an depth of focus longer than the diffraction-limited depth-of-focus. For example, the system of FIG. 15A generates the results by a factor of, e.g., approximately 2, 5, 10, 20, 50, 100, etc. An output of a waveguide 1500 can be collimated by one or more lens(es) 1510. The collimated beam can be spatially modulated by a phase doublet 1520, which can include a positive phase plate and a negative phase plate with the same or similar phase pattern. By matching Abbe number of the positive phase plate and the negative phase plate, the wavelength dependent phase error can be canceled or reduced. FIG. 15B shows an exemplary graph of transverse phase profiles of an exemplary mask (e.g., BK7-SNPH2 phase doublet mask) illustrated in FIG. 15A For example, by choosing Ohara S-NPH2 (Vd=18.896912, Nd=1.922860) and Schott BK7 (Vd=64.167336, Nd=1.5168), with depth 7.2554 um and 13.4668 um respectively, the phase profile is shown in FIG. 15B . The spatially modulated beam can be focused into an extended axial focus by an objective lens 1530.
[0110] FIG. 16 shows still another exemplary embodiment of the distal optics configuration of the OCT catheter system for generating a diffraction-limited CTF and depth of focus according to the present disclosure that is longer than the diffraction-limited depth-of-focus, by a factor of preferably approximately 2, 5, 10, 20, 50, 100, etc. An output of a light source 1600 can be split by a beam splitter 1610. The beam aperture of at least one of the outputs of the beam splitter can be split or separated by a rod mirror 1620 into two or more regions. For example, the rod mirror 1620 can redirect the central part of the beam to a reference reflector 1630 through an objective lens 1640. The annular beam can be focused into the sample by a second objective lens 1660 that can be substantially similar or identical to one or more lens(es) 1640 into a Bessel focus featured with extended axial focus and super-resolution in transverse direction (as shown in the exemplary μOCT images of FIG. 18D ). The light back-scattered from the sample is combined with the light reflected from the reference reflector through the rod mirror at a pinhole 1660. The output of the pinhole 1660 is detected by a spectrometer 1670. The objective lens 1650 is configured to intentionally generate chromatic aberration and spherical aberration, which extend the axial focus further (as shown in the exemplary μOCT images of FIGS. 18C and 18D ). FIG. 18A shows an exemplary μOCT image of a coronary plaque showing multiple leukocytes (arrows). In addition, FIG. 18B shows an exemplary μOCT image of a coronary plaque illustrating multiple leukocytes (arrows) of two different cell types, one smaller cell with scant cytoplasm, consistent with a lymphocyte (L) and another, larger cell with a highly scattering cytoplasm, indicative of a monocyte (M).
[0111] Indeed, FIG. 18A illustrates an exemplary μOCT image of a coronary plaque showing multiple leukocytes 1800 which has been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. FIG. 18B illustrates an exemplary μOCT image of a coronary plaque showing multiple leukocytes of two different cell types, one smaller cell 1810 with scant cytoplasm, consistent with a lymphocyte and another, larger cell 1820 with a highly scattering cytoplasm, suggestive of a monocyte. FIG. 18C illustrates an exemplary μOCT image of a coronary plaque showing a cell 1830 with an indented, bean-shaped nucleus characteristic of a monocyte. FIG. 18D illustrates an exemplary μOCT image of a coronary plaque showing a leukocyte 1840 with a multi-lobed nucleus, suggestive of a neutrophil attached to the endothelial surface. FIG. 18E illustrates an exemplary μOCT image of a coronary plaque showing multiple leukocytes 1850, tethered to the endothelial surface by pseudopodia 1860. FIG. 18F illustrates an exemplary μOCT image of a coronary plaque showing cells 1870 with the morphology of monocytes in this cross-section and inset transmigrating through the endothelium 1880. Further, FIG. 18G illustrates an exemplary μOCT image of multiple leukocytes 1890 distributed on the endothelial surface.
[0112] FIG. 19A-19E show exemplary images which have been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. For example FIG. 19A illustrates an exemplary μOCT image of platelets 1900 (P) adjacent to a leukocyte characteristic of a neutrophil 1910 (N), which is also attached to a small platelet 1920 (yellow arrow). FIG. 19B illustrates an exemplary μOCT image of fibrin 1930 (F) which is visible as linear strands bridging a gap in the coronary artery wall. FIG. 19C illustrates an exemplary μOCT image of a cluster of leukocytes 1940 (L), adherent to the fibrin in an adjacent site to FIG. 19B . FIG. 19D illustrates an exemplary μOCT image of Fibrin thrombus 1950 (T) with multiple, entrapped leukocytes. FIG. 19E an μOCT image of a more advanced thrombus 1960 (T) showing a leukocyte 1970 (arrow) and fibrin strands 1980 (inset, F).
[0113] FIGS. 20A-20D show further exemplary images which have been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. For example, FIG. 20A illustrates a cross-sectional exemplary μOCT image of endothelial cells 2000 in culture. FIG. 20B shows an en face exemplary μOCT image of endothelial cells 2010 in culture. FIG. 20C illustrates an exemplary μOCT image of native swine coronary artery cross-section 2020. FIG. 20D shows a three-dimensional rendering of the swine coronary artery, demonstrating endothelial “pavementing” 2030.\
[0114] FIGS. 21A and 21B show further exemplary images which have been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. FIG. 21A shows an exemplary μOCT image of microcalcifications which are seen as bright densities within the μOCT image of the fibrous cap 2100. FIG. 21B illustrates an exemplary μOCT image of microcalcifications which are seen as purple densities on the corresponding histology 2110.
[0115] Further, FIGS. 22A-22C illustrate further exemplary images which have been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. For example, FIG. 22A shows an exemplary μOCT image of a large calcium nodule, demonstrating disrupted intima/endothelium 2200. FIG. 22B shows an expanded view of an exemplary region enclosed by the red box shows microscopic tissue strands, consistent with fibrin 2210, adjoining the unprotected calcium 2220 to the opposing detached intima. FIG. 22C shows a corresponding histology illustrating fibrin 2230 and denuded calcific surface 2240.
[0116] In addition, FIGS. 23A-26C illustrate further exemplary images which have been generated using the exemplary embodiment(s) of the methods, systems and apparatus according to the present disclosure. For example, FIG. 23A shows an exemplary μOCT image of a large necrotic core 2300 fibroatheroma, demonstrating thick cholesterol crystals 2310, characterized by reflections from their top and bottom surfaces. FIG. 23B shows an exemplary μOCT image of thin crystal 2320, piercing the cap of another necrotic core plaque 2330, shown in more detail in the inset. FIG. 24A shows an exemplary μOCT image of many smooth muscle cells 2400 appear as low backscattering spindle-shaped cells (inset). FIG. 24B shows an exemplary μOCT image of smooth muscle cells producing collagen are spindle shaped, have a high backscattering interior 2410 and a “halo” of low backscattering 2420, which can represent the cell body 2430 and collagen matrix 2440, respectively (e.g., histology inset).
[0117] FIG. 25A shows an exemplary μOCT image of Taxus Liberte (Boston Scientific, Natick, Mass.) struts without polymer 2500, with polymer without drug 2510, and with polymer with drug 2520. For polymer-coated struts, polymer reflection 2530, strut reflection 2540 and multiple reflections 2550 and 2560 can be seen. FIG. 25B shows an exemplary μOCT image of a cadaver coronary specimen with an implanted BMS 2570 shows struts devoid of polymer, covered by neointima 2580. FIG. 25C shows an exemplary μOCT image of a cadaver coronary specimen with implanted DES struts 2590 from another cadaver showing polymer overlying the strut reflections 2595 (inset).
[0118] In addition, FIG. 26A shows an exemplary μOCT image showing tissue 2600 has separated the polymer 2610 off of the stent strut 2620 and the polymer has fractured 2630. FIG. 26B shows an exemplary μOCT image showing superficial leukocyte cluster 2640 and adjacent attached leukocytes 2650 overlying the site of the polymer fracture 2660. FIG. 26C shows an exemplary μOCT image showing inflammation 2670 at the edge of a strut 2680 from another patient. FIG. 26D shows an exemplary μOCT image showing uncovered strut 2690, completely devoid of overlying endothelium.
[0119] In still another exemplary embodiment of the present disclosure, the optical elements for the exemplary μOCT system/probe can be fabricated by irradiating a photopolymer with a tightly focused beam, whose position can be controlled in three-dimensions with nm-level precision. The photopolymer can respond to a variable refractive index that can be proportional to an optical energy deposited, facilitating a miniature, solid volume to implement complex optical functionality. (See, e.g., Sullivan A C, Grabowski M W and McLeod R R, “Three-dimensional direct-write lithography into photopolymer”, Applied Optics 2007; 46: 295-301; and Scott T F, Kowalski B A, Sullivan A C, Bowman C N and McLeod R R, “Two-Color Single-Photon Photoinitiation and Photoinhibition for Subdiffraction Photolithography”, Science 2009; 324: 913-7; also see U.S. Patent Publication Nos. 2009/0218519 and 2006/0193579).
[0120] Such exemplary method and procedure previously generated miniature fiber couplers, tapered waveguides, waveguide arrays, lenses, diffractive optical elements, and complex optical assemblies, all within a monolithic, polymer component, for example. This exemplary embodiment facilitates the exemplary μOCT probe to be a stable, monolithic element that can provide the extended focal depth functionality described herein, than can be incorporated into, e.g., miniaturized μOCT catheters and endoscopes. One advantage of this exemplary embodiment is that the photopolymer-derived optical element/arrangement can be made repeatedly with a high precision, and can be mass-produced at relatively low cost.
[0121] FIG. 27A shows a flow diagram of a method for providing data associated with at least one portion of at least one sample according to one exemplary embodiment of the present disclosure. For example, in procedure 2710, at least one first radiation is forwarded to at least one portion of the sample through at least one optical arrangement (e.g., as described in various exemplary embodiments herein), and at least one second radiation is received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement has a first transfer function. Then, in procedure 2720, at least one third radiation is forwarded to the portion through such optical arrangement, and at least one fourth radiation is received from the portion which is based on the third radiation. Based on an interaction between this optical arrangement and the third radiation and/or the fourth radiation, the optical arrangement has a second transfer function. The first transfer function can be at least partially different from the second transfer function. Further, in procedure 2730, the data associated with the portion(s) can be generated based on the second and fourth radiations.
[0122] FIG. 27B shows a flow diagram of the method for providing data associated with at least one portion of at least one sample according to another exemplary embodiment of the present disclosure. For example, in procedure 2760, at least one first radiation is forwarded to at least one portion of the sample through at least one first optical arrangement (e.g., as described in various exemplary embodiments herein), and at least one second radiation is received from the portion which is based on the first radiation. Based on an interaction between the first optical arrangement and the first radiation and/or the second radiation, the first optical arrangement has a first transfer function. Then, in procedure 2770, at least one third radiation is forwarded to the portion through at least one second optical arrangement, and at least one fourth radiation is received from the portion which is based on the third radiation. Based on an interaction between the second optical arrangement and the third radiation and/or the fourth radiation, the optical arrangement has a second transfer function. The first transfer function can be at least partially different from the second transfer function. Further, in procedure 2780, the data associated with the portion(s) can be generated based on the second and fourth radiations.
[0123] The foregoing merely illustrates the principles of the present disclosure. Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein. For example, more than one of the described exemplary arrangements, radiations and/or systems can be implemented to implement the exemplary embodiments of the present disclosure Indeed, the arrangements, systems and methods according to the exemplary embodiments of the present invention can be used with and/or implement any OCT system, OFDI system, SD-OCT system or other imaging systems, and for example with those described in International Patent Application PCT/US2004/029148 filed Sep. 8, 2004 (which published as International Patent Publication No. WO 2005/047813 on May 26, 2005), U.S. patent application Ser. No. 11/266,779 filed Nov. 2, 2005 (which published as U.S. Patent Publication No. 2006/0093276 on May 4, 2006), U.S. patent application Ser. No. 10/861,179 filed Jun. 4, 2004, U.S. patent application Ser. No. 10/501,276 filed Jul. 9, 2004 (which published as U.S. Patent Publication No. 2005/0018201 on Jan. 27, 2005), U.S. patent application Ser. No. 11/445,990 filed Jun. 1, 2006, International Patent Application PCT/US2007/066017 filed Apr. 5, 2007, and U.S. patent application Ser. No. 11/502,330 filed Aug. 9, 2006, the disclosures of which are incorporated by reference herein in their entireties. It will thus be appreciated that those skilled in the art will be able to devise numerous systems, arrangements and methods which, although not explicitly shown or described herein, embody the principles of the present disclosure and are thus within the spirit and scope of the present disclosure. In addition, to the extent that the prior art knowledge has not been explicitly incorporated by reference herein above, it is explicitly being incorporated herein in its entirety. All publications referenced herein above are incorporated herein by reference in their entireties.
Claims
What is claimed is:
1. An apparatus for providing at least one electro-magnetic radiation to at least one sample, comprising:
a pre-fabricated optical mask;
a plurality of wave-guiding arrangements configured to (i) provide the at least one electro-magnetic radiation along different paths, and (ii) at a point of emission of each of the wave guiding arrangements, forward each of the at least one electro-magnetic radiation to the optical mask, which causes a phase of each of the at least one electro-magnetic radiations to have a predetermined value; and
at least one lens arrangement which is configured to receive the at least one electro-magnetic radiation from the wave-guiding arrangements, and generate a focus-spot radiation which has an extended focal depth.
2. The apparatus according to claim 1, wherein the wave-guiding arrangements provide the at least one radiation in at least partially a circular pattern.
3. The apparatus according to claim 1, wherein the at least one lens arrangement is configured to cause the further focus-spot radiation to have an extended focal depth.
4. The apparatus according to claim 1, wherein the at least one lens arrangement is configured to cause the further focus-spot radiation to have a diameter that is smaller than a diffraction limited spot on or in the sample.
5. The apparatus according to claim 4, wherein the diffraction limited spot is a three-dimensional spot.
6. The apparatus according to claim 1, wherein the at least one lens arrangement includes a grin lens.
7. The apparatus according to claim 1, wherein at least one of the wave-guiding arrangements is a single-mode wave-guide.
8. The apparatus according to claim 1, wherein at least one of the wave-guiding arrangements is composed of a photo-polymer.
9. The apparatus according to claim 1, further comprising a further wave-guiding arrangement is configured to provide a further electro-magnetic radiation to the sample, wherein the at least one electro-magnetic radiation and the further electro-magnetic radiation are provided to at least partially overlapping portions of the sample.
10. The apparatus according to claim 1, further comprising a housing which at least partially encloses the wave-guiding arrangements.
11. The apparatus according to claim 10, further comprising a sheath enclosing the housing.
12. The apparatus according to claim 10, further comprising a control arrangement which is configured to at least one of rotate or translate the housing.
13. The apparatus according to claim 1, wherein the at least one lens arrangement includes at least one optical element which is at least one formed by or subjected to a photopolymer processing.
14. The apparatus according to claim 13, wherein the photopolymer processing includes irradiating a photopolymer so as to form the at least one optical element.
15. A probe for providing at least one electro-magnetic radiation to at least one sample, comprising:
a pre-fabricated optical mask;
a plurality of wave-guiding arrangements configured to (i) provide the at least one electro-magnetic radiation along different paths, and (ii) at a point of emission of each of the wave guiding arrangements, forward each of the at least one electro-magnetic radiations to the optical mask, which causes a phase of each of the at least one electro-magnetic radiations to have a predetermined value; and
at least one lens arrangement which is configured to receive the at least one electro-magnetic radiation from the wave-guiding arrangements, and generate a focus-spot radiation which has an extended focal depth.
16. A system for imaging at least one sample, comprising:
a pre-fabricated optical mask;
a probe comprising a plurality of wave-guiding arrangements configured to (i) provide at least one electro-magnetic radiation to the at least one sample along different paths, and (ii) at a point of emission of each of the wave guiding arrangements, forward each of the at least one electro-magnetic radiations to the optical mask, which causes a phase of each of the at least one electro-magnetic radiations to have a predetermined value;
an interferometric arrangement provided in communication with the probe; and
at least one lens arrangement which is configured to receive the at least one electro-magnetic radiation from the wave-guiding arrangements, and generate a focus-spot radiation which has an extended focal depth.
17. The system according to claim 16, wherein the interferometric arrangement is part of the probe.
Patent Citations (773)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US2339754(A) | 1944-01-01 | Brace | Applicant |
| US3090753(A) | 1963-05-01 | Matuszak et al. | Applicant |
| US3601480(A) | 1971-08-01 | Randall | Applicant |
| US3856000(A) | 1974-12-01 | Chikama | Applicant |
| US3872407(A) | 1975-03-01 | Hughes | Applicant |
| US3941121(A) | 1976-03-01 | Olinger | Applicant |
| US3973219(A) | 1976-08-01 | Tang et al. | Applicant |
| US3983507(A) | 1976-09-01 | Tang et al. | Applicant |
| US4030827(A) | 1977-06-01 | Delhaye et al. | Applicant |
| US4030831(A) | 1977-06-01 | Gowrinathan | Applicant |
| US4140364(A) | 1979-02-01 | Yamashita et al. | Applicant |
| US4141362(A) | 1979-02-01 | Wurster | Applicant |
| US4224929(A) | 1980-09-01 | Furihata | Applicant |
| US4295738(A) | 1981-10-01 | Meltz et al. | Applicant |
| US4300816(A) | 1981-11-01 | Snitzer et al. | Applicant |
| US4303300(A) | 1981-12-01 | Pressiat et al. | Applicant |
| US4428643(A) | 1984-01-01 | Kay | Applicant |
| US4479499(A) | 1984-10-01 | Alfano et al. | Applicant |
| US4533247(A) | 1985-08-01 | Epworth | Applicant |
| US4585349(A) | 1986-04-01 | Gross et al. | Applicant |
| US4601036(A) | 1986-07-01 | Faxvog et al. | Applicant |
| US4607622(A) | 1986-08-01 | Fritch et al. | Applicant |
| US4631498(A) | 1986-12-01 | Cutler | Applicant |
| US4639999(A) | 1987-02-01 | Daniele | Applicant |
| US4650327(A) | 1987-03-01 | Ogi | Applicant |
| US4734578(A) | 1988-03-01 | Horikawa | Applicant |
| US4744656(A) | 1988-05-01 | Moran et al. | Applicant |
| US4751706(A) | 1988-06-01 | Rohde et al. | Applicant |
| US4763977(A) | 1988-08-01 | Kawasaki et al. | Applicant |
| US4770492(A) | 1988-09-01 | Levin et al. | Applicant |
| US4827907(A) | 1989-05-01 | Tashiro et al. | Applicant |
| US4834111(A) | 1989-05-01 | Khanna et al. | Applicant |
| US4868834(A) | 1989-09-01 | Fox et al. | Applicant |
| US4890901(A) | 1990-01-01 | Cross, Jr. | Applicant |
| US4892406(A) | 1990-01-01 | Waters | Applicant |
| US4905169(A) | 1990-02-01 | Buican et al. | Applicant |
| US4909631(A) | 1990-03-01 | Tan et al. | Applicant |
| US4925302(A) | 1990-05-01 | Cutler | Applicant |
| US4928005(A) | 1990-05-01 | Lefèvre et al. | Applicant |
| US4940328(A) | 1990-07-01 | Hartman | Applicant |
| US4965441(A) | 1990-10-01 | Picard | Applicant |
| US4965599(A) | 1990-10-01 | Roddy et al. | Applicant |
| US4966589(A) | 1990-10-01 | Kaufman | Applicant |
| US4984888(A) | 1991-01-01 | Tobias et al. | Applicant |
| US4993834(A) | 1991-02-01 | Carlhoff et al. | Applicant |
| US4998972(A) | 1991-03-01 | Chin et al. | Applicant |
| US5039193(A) | 1991-08-01 | Snow et al. | Applicant |
| US5040889(A) | 1991-08-01 | Keane | Applicant |
| US5045936(A) | 1991-09-01 | Lobb et al. | Applicant |
| US5046501(A) | 1991-09-01 | Crilly | Applicant |
| US5065331(A) | 1991-11-01 | Vachon et al. | Applicant |
| US5085496(A) | 1992-02-01 | Yoshida et al. | Applicant |
| US5120953(A) | 1992-06-01 | Harris | Applicant |
| US5121983(A) | 1992-06-01 | Lee | Applicant |
| US5127730(A) | 1992-07-01 | Brelje et al. | Applicant |
| US5177488(A) | 1993-01-01 | Wang et al. | Applicant |
| US5197470(A) | 1993-03-01 | Helfer et al. | Applicant |
| US5202745(A) | 1993-04-01 | Sorin et al. | Applicant |
| US5202931(A) | 1993-04-01 | Bacus et al. | Applicant |
| US5208651(A) | 1993-05-01 | Buican | Applicant |
| US5212667(A) | 1993-05-01 | Tomlinson et al. | Applicant |
| US5214538(A) | 1993-05-01 | Lobb | Applicant |
| US5217456(A) | 1993-06-01 | Narciso, Jr. | Applicant |
| US5228001(A) | 1993-07-01 | Birge et al. | Applicant |
| US5241364(A) | 1993-08-01 | Kimura et al. | Applicant |
| US5248876(A) | 1993-09-01 | Kerstens et al. | Applicant |
| US5250186(A) | 1993-10-01 | Dollinger et al. | Applicant |
| US5251009(A) | 1993-10-01 | Bruno | Applicant |
| US5262644(A) | 1993-11-01 | Maguire | Applicant |
| US5275594(A) | 1994-01-01 | Baker | Applicant |
| US5281811(A) | 1994-01-01 | Lewis | Applicant |
| US5283795(A) | 1994-02-01 | Fink | Applicant |
| US5291885(A) | 1994-03-01 | Taniji et al. | Applicant |
| US5293872(A) | 1994-03-01 | Alfano et al. | Applicant |
| US5293873(A) | 1994-03-01 | Fang | Applicant |
| US5302025(A) | 1994-04-01 | Kleinerman | Applicant |
| US5304173(A) | 1994-04-01 | Kittrell et al. | Applicant |
| US5304810(A) | 1994-04-01 | Amos | Applicant |
| US5305759(A) | 1994-04-01 | Kaneko et al. | Applicant |
| US5317389(A) | 1994-05-01 | Hochberg et al. | Applicant |
| US5318024(A) | 1994-06-01 | Kittrell et al. | Applicant |
| US5321501(A) | 1994-06-01 | Swanson et al. | Applicant |
| US5333144(A) | 1994-07-01 | Liedenbaum et al. | Applicant |
| US5348003(A) | 1994-09-01 | Caro | Applicant |
| US5353790(A) | 1994-10-01 | Jacques et al. | Applicant |
| US5383467(A) | 1995-01-01 | Auer et al. | Applicant |
| US5394235(A) | 1995-02-01 | Takeuchi et al. | Applicant |
| US5400771(A) | 1995-03-01 | Pirak et al. | Applicant |
| US5404415(A) | 1995-04-01 | Mori et al. | Applicant |
| US5411016(A) | 1995-05-01 | Kume et al. | Applicant |
| US5414509(A) | 1995-05-01 | Veligdan | Applicant |
| US5419323(A) | 1995-05-01 | Kittrell et al. | Applicant |
| US5424827(A) | 1995-06-01 | Horwitz et al. | Applicant |
| US5439000(A) | 1995-08-01 | Gunderson et al. | Applicant |
| US5441053(A) | 1995-08-01 | Lodder et al. | Applicant |
| US5450203(A) | 1995-09-01 | Penkethman | Applicant |
| US5454807(A) | 1995-10-01 | Lennox et al. | Applicant |
| US5459325(A) | 1995-10-01 | Hueton et al. | Applicant |
| US5459570(A) | 1995-10-01 | Swanson et al. | Applicant |
| US5465147(A) | 1995-11-01 | Swanson | Applicant |
| US5479928(A) | 1996-01-01 | Cathignoal et al. | Applicant |
| US5486701(A) | 1996-01-01 | Norton et al. | Applicant |
| US5491524(A) | 1996-02-01 | Hellmuth et al. | Applicant |
| US5491552(A) | 1996-02-01 | Knuttel | Applicant |
| US5522004(A) | 1996-05-01 | Djupsjobacka et al. | Applicant |
| US5526338(A) | 1996-06-01 | Hasman et al. | Applicant |
| US5555087(A) | 1996-09-01 | Miyagawa et al. | Applicant |
| US5562100(A) | 1996-10-01 | Kittrell et al. | Applicant |
| US5565983(A) | 1996-10-01 | Barnard et al. | Applicant |
| US5565986(A) | 1996-10-01 | Knüttel | Applicant |
| US5566267(A) | 1996-10-01 | Neuberger | Applicant |
| US5583342(A) | 1996-12-01 | Ichie | Applicant |
| US5590660(A) | 1997-01-01 | MacAulay et al. | Applicant |
| US5600486(A) | 1997-02-01 | Gal et al. | Applicant |
| US5601087(A) | 1997-02-01 | Gunderson et al. | Applicant |
| US5621830(A) | 1997-04-01 | Lucey et al. | Applicant |
| US5623336(A) | 1997-04-01 | Raab et al. | Applicant |
| US5628313(A) | 1997-05-01 | Webster, Jr. | Applicant |
| US5635830(A) | 1997-06-01 | Itoh | Applicant |
| US5649924(A) | 1997-07-01 | Everett et al. | Applicant |
| US5697373(A) | 1997-12-01 | Richards-Kortum et al. | Applicant |
| US5698397(A) | 1997-12-01 | Zarling et al. | Applicant |
| US5701155(A) | 1997-12-01 | Wood et al. | Applicant |
| US5710630(A) | 1998-01-01 | Essenpreis et al. | Applicant |
| US5716324(A) | 1998-02-01 | Toida | Applicant |
| US5719399(A) | 1998-02-01 | Alfano et al. | Applicant |
| US5730731(A) | 1998-03-01 | Mollenauer et al. | Applicant |
| US5735276(A) | 1998-04-01 | Lemelson | Applicant |
| US5740808(A) | 1998-04-01 | Panescu et al. | Applicant |
| US5748318(A) | 1998-05-01 | Maris et al. | Applicant |
| US5748598(A) | 1998-05-01 | Swanson et al. | Applicant |
| US5752518(A) | 1998-05-01 | McGee et al. | Applicant |
| US5784352(A) | 1998-07-01 | Swanson et al. | Applicant |
| US5785651(A) | 1998-07-01 | Kuhn et al. | Applicant |
| US5795295(A) | 1998-08-01 | Hellmuth et al. | Applicant |
| US5801826(A) | 1998-09-01 | Williams | Applicant |
| US5801831(A) | 1998-09-01 | Sargoytchev et al. | Applicant |
| US5803082(A) | 1998-09-01 | Stapleton et al. | Applicant |
| US5807261(A) | 1998-09-01 | Benaron et al. | Applicant |
| US5810719(A) | 1998-09-01 | Toida | Applicant |
| US5817144(A) | 1998-10-01 | Gregory | Applicant |
| US5829439(A) | 1998-11-01 | Yokosawa et al. | Applicant |
| US5836877(A) | 1998-11-01 | Zavislan et al. | Applicant |
| US5840023(A) | 1998-11-01 | Oraevsky et al. | Applicant |
| US5840031(A) | 1998-11-01 | Crowley | Applicant |
| US5840075(A) | 1998-11-01 | Mueller et al. | Applicant |
| US5842995(A) | 1998-12-01 | Mahadevan-Jansen et al. | Applicant |
| US5843000(A) | 1998-12-01 | Nishioka et al. | Applicant |
| US5843052(A) | 1998-12-01 | Benja-Athon | Applicant |
| US5847827(A) | 1998-12-01 | Fercher | Applicant |
| US5852293(A) | 1998-12-01 | Iwasaki et al. | Applicant |
| US5862273(A) | 1999-01-01 | Pelletier | Applicant |
| US5865754(A) | 1999-02-01 | Sevick-Muraca et al. | Applicant |
| US5867268(A) | 1999-02-01 | Gelikonov et al. | Applicant |
| US5871449(A) | 1999-02-01 | Brown | Applicant |
| US5872879(A) | 1999-02-01 | Hamm | Applicant |
| US5877856(A) | 1999-03-01 | Fercher | Applicant |
| US5887009(A) | 1999-03-01 | Mandella et al. | Applicant |
| US5892583(A) | 1999-04-01 | Li | Applicant |
| US5910839(A) | 1999-06-01 | Erskine et al. | Applicant |
| US5912764(A) | 1999-06-01 | Togino | Applicant |
| US5920373(A) | 1999-07-01 | Bille | Applicant |
| US5920390(A) | 1999-07-01 | Farahi et al. | Applicant |
| US5921926(A) | 1999-07-01 | Rolland et al. | Applicant |
| US5926592(A) | 1999-07-01 | Harris et al. | Applicant |
| US5949929(A) | 1999-09-01 | Hamm | Applicant |
| US5951482(A) | 1999-09-01 | Winston et al. | Applicant |
| US5955737(A) | 1999-09-01 | Hallidy et al. | Applicant |
| US5956355(A) | 1999-09-01 | Swanson et al. | Applicant |
| US5968064(A) | 1999-10-01 | Selmon et al. | Applicant |
| US5975697(A) | 1999-11-01 | Podoleanu et al. | Applicant |
| US5983125(A) | 1999-11-01 | Alfano et al. | Applicant |
| US5987346(A) | 1999-11-01 | Benaron et al. | Applicant |
| US5991697(A) | 1999-11-01 | Nelson et al. | Applicant |
| US5994690(A) | 1999-11-01 | Kulkarni et al. | Applicant |
| US5995223(A) | 1999-11-01 | Power | Applicant |
| US6002480(A) | 1999-12-01 | Izatt et al. | Applicant |
| US6004314(A) | 1999-12-01 | Wei et al. | Applicant |
| US6006128(A) | 1999-12-01 | Izatt et al. | Applicant |
| US6007996(A) | 1999-12-01 | McNamara et al. | Applicant |
| US6010449(A) | 2000-01-01 | Selmon et al. | Applicant |
| US6014214(A) | 2000-01-01 | Li | Applicant |
| US6016197(A) | 2000-01-01 | Krivoshlykov | Applicant |
| US6020963(A) | 2000-02-01 | Dimarzio et al. | Applicant |
| US6025956(A) | 2000-02-01 | Nagano et al. | Applicant |
| US6033721(A) | 2000-03-01 | Nassuphis | Applicant |
| US6037579(A) | 2000-03-01 | Chan et al. | Applicant |
| US6044288(A) | 2000-03-01 | Wake et al. | Applicant |
| US6045511(A) | 2000-04-01 | Ott et al. | Applicant |
| US6048742(A) | 2000-04-01 | Weyburne et al. | Applicant |
| US6052186(A) | 2000-04-01 | Tsai | Applicant |
| US6053613(A) | 2000-04-01 | Wei et al. | Applicant |
| US6069698(A) | 2000-05-01 | Ozawa et al. | Applicant |
| US6078047(A) | 2000-06-01 | Mittleman et al. | Applicant |
| US6091496(A) | 2000-07-01 | Hill | Applicant |
| US6091984(A) | 2000-07-01 | Perelman et al. | Applicant |
| US6094274(A) | 2000-07-01 | Yokoi | Applicant |
| US6107048(A) | 2000-08-01 | Goldenring et al. | Applicant |
| US6111645(A) | 2000-08-01 | Tearney et al. | Applicant |
| US6117128(A) | 2000-09-01 | Gregory | Applicant |
| US6120516(A) | 2000-09-01 | Selmon et al. | Applicant |
| US6134003(A) | 2000-10-01 | Tearney et al. | Applicant |
| US6134010(A) | 2000-10-01 | Zavislan | Applicant |
| US6134033(A) | 2000-10-01 | Bergano et al. | Applicant |
| US6141577(A) | 2000-10-01 | Rolland et al. | Applicant |
| US6151522(A) | 2000-11-01 | Alfano et al. | Applicant |
| US6159445(A) | 2000-12-01 | Klaveness et al. | Applicant |
| US6160826(A) | 2000-12-01 | Swanson et al. | Applicant |
| US6161031(A) | 2000-12-01 | Hochmann et al. | Applicant |
| US6166373(A) | 2000-12-01 | Mao | Applicant |
| US6174291(B1) | 2001-01-01 | McMahon et al. | Applicant |
| US6175669(B1) | 2001-01-01 | Colston et al. | Applicant |
| US6185271(B1) | 2001-02-01 | Kinsinger | Applicant |
| US6191862(B1) | 2001-02-01 | Swanson et al. | Applicant |
| US6193676(B1) | 2001-02-01 | Winston et al. | Applicant |
| US6198956(B1) | 2001-03-01 | Dunne | Applicant |
| US6201989(B1) | 2001-03-01 | Whitehead et al. | Applicant |
| US6208415(B1) | 2001-03-01 | De Boer et al. | Applicant |
| US6208887(B1) | 2001-03-01 | Clarke | Applicant |
| US6245026(B1) | 2001-06-01 | Campbell et al. | Applicant |
| US6249349(B1) | 2001-06-01 | Lauer | Applicant |
| US6249381(B1) | 2001-06-01 | Suganuma | Applicant |
| US6249630(B1) | 2001-06-01 | Stock et al. | Applicant |
| US6263234(B1) | 2001-07-01 | Engelhardt et al. | Applicant |
| US6264610(B1) | 2001-07-01 | Zhu | Applicant |
| US6272268(B1) | 2001-08-01 | Miller et al. | Applicant |
| US6272376(B1) | 2001-08-01 | Marcu et al. | Applicant |
| US6274871(B1) | 2001-08-01 | Dukor et al. | Applicant |
| US6282011(B1) | 2001-08-01 | Tearney et al. | Applicant |
| US6297018(B1) | 2001-10-01 | French et al. | Applicant |
| US6301048(B1) | 2001-10-01 | Cao et al. | Applicant |
| US6308092(B1) | 2001-10-01 | Hoyns | Applicant |
| US6324419(B1) | 2001-11-01 | Guzelsu et al. | Applicant |
| US6341036(B1) | 2002-01-01 | Tearney et al. | Applicant |
| US6353693(B1) | 2002-03-01 | Kano et al. | Applicant |
| US6359692(B1) | 2002-03-01 | Groot | Applicant |
| US6374128(B1) | 2002-04-01 | Toida et al. | Applicant |
| US6377349(B1) | 2002-04-01 | Fercher | Applicant |
| US6384915(B1) | 2002-05-01 | Everett et al. | Applicant |
| US6393312(B1) | 2002-05-01 | Hoyns | Applicant |
| US6394964(B1) | 2002-05-01 | Sievert, Jr. et al. | Applicant |
| US6396941(B1) | 2002-05-01 | Bacus et al. | Applicant |
| US6421164(B2) | 2002-07-01 | Tearney et al. | Applicant |
| US6437867(B2) | 2002-08-01 | Zeylikovich et al. | Applicant |
| US6441892(B2) | 2002-08-01 | Xiao et al. | Applicant |
| US6441959(B1) | 2002-08-01 | Yang et al. | Applicant |
| US6445485(B1) | 2002-09-01 | Frigo et al. | Applicant |
| US6445939(B1) | 2002-09-01 | Swanson et al. | Applicant |
| US6445944(B1) | 2002-09-01 | Ostrovsky | Applicant |
| US6459487(B1) | 2002-10-01 | Chen et al. | Applicant |
| US6463313(B1) | 2002-10-01 | Winston et al. | Applicant |
| US6469846(B2) | 2002-10-01 | Ebizuka et al. | Applicant |
| US6475159(B1) | 2002-11-01 | Casscells et al. | Applicant |
| US6475210(B1) | 2002-11-01 | Phelps et al. | Applicant |
| US6477403(B1) | 2002-11-01 | Eguchi et al. | Applicant |
| US6485413(B1) | 2002-11-01 | Boppart et al. | Applicant |
| US6485482(B1) | 2002-11-01 | Belef | Applicant |
| US6501551(B1) | 2002-12-01 | Tearney et al. | Applicant |
| US6501878(B2) | 2002-12-01 | Hughes et al. | Applicant |
| US6516014(B1) | 2003-02-01 | Sellin et al. | Applicant |
| US6517532(B1) | 2003-02-01 | Altshuler et al. | Applicant |
| US6538817(B1) | 2003-03-01 | Farmer et al. | Applicant |
| US6540391(B2) | 2003-04-01 | Lanzetta et al. | Applicant |
| US6549801(B1) | 2003-04-01 | Chen et al. | Applicant |
| US6552796(B2) | 2003-04-01 | Magnin et al. | Applicant |
| US6556305(B1) | 2003-04-01 | Aziz et al. | Applicant |
| US6556853(B1) | 2003-04-01 | Cabib et al. | Applicant |
| US6558324(B1) | 2003-05-01 | Von Behren et al. | Applicant |
| US6560259(B1) | 2003-05-01 | Hwang et al. | Applicant |
| US6564087(B1) | 2003-05-01 | Pitris et al. | Applicant |
| US6564089(B2) | 2003-05-01 | Izatt et al. | Applicant |
| US6567585(B2) | 2003-05-01 | Harris et al. | Applicant |
| US6593101(B2) | 2003-07-01 | Richards-Kortum et al. | Applicant |
| US6611833(B1) | 2003-08-01 | Johnson et al. | Applicant |
| US6615071(B1) | 2003-09-01 | Casscells, III et al. | Applicant |
| US6622732(B2) | 2003-09-01 | Constantz | Applicant |
| US6654127(B2) | 2003-11-01 | Everett et al. | Applicant |
| US6657730(B2) | 2003-12-01 | Pfau et al. | Applicant |
| US6658278(B2) | 2003-12-01 | Gruhl | Applicant |
| US6680780(B1) | 2004-01-01 | Fee | Applicant |
| US6685885(B2) | 2004-02-01 | Nolte et al. | Applicant |
| US6687007(B1) | 2004-02-01 | Meigs | Applicant |
| US6687010(B1) | 2004-02-01 | Horii et al. | Applicant |
| US6687036(B2) | 2004-02-01 | Riza | Applicant |
| US6692430(B2) | 2004-02-01 | Adler | Applicant |
| US6701181(B2) | 2004-03-01 | Tang et al. | Applicant |
| US6721094(B1) | 2004-04-01 | Sinclair et al. | Applicant |
| US6725073(B1) | 2004-04-01 | Motamedi et al. | Applicant |
| US6738144(B1) | 2004-05-01 | Dogariu et al. | Applicant |
| US6741355(B2) | 2004-05-01 | Drabarek | Applicant |
| US6741884(B1) | 2004-05-01 | Freeman et al. | Applicant |
| US6757467(B1) | 2004-06-01 | Rogers | Applicant |
| US6790175(B1) | 2004-09-01 | Furusawa et al. | Applicant |
| US6806963(B1) | 2004-10-01 | Wälti et al. | Applicant |
| US6816743(B2) | 2004-11-01 | Moreno et al. | Applicant |
| US6831781(B2) | 2004-12-01 | Tearney et al. | Applicant |
| US6839496(B1) | 2005-01-01 | Mills et al. | Applicant |
| US6882432(B2) | 2005-04-01 | Deck | Applicant |
| US6900899(B2) | 2005-05-01 | Nevis | Applicant |
| US6903820(B2) | 2005-06-01 | Wang | Applicant |
| US6909105(B1) | 2005-06-01 | Heintzmann et al. | Applicant |
| US6949072(B2) | 2005-09-01 | Furnish et al. | Applicant |
| US6961123(B1) | 2005-11-01 | Wang et al. | Applicant |
| US6980299(B1) | 2005-12-01 | de Boer | Applicant |
| US6996549(B2) | 2006-02-01 | Zhang et al. | Applicant |
| US7006231(B2) | 2006-02-01 | Ostrovsky et al. | Applicant |
| US7006232(B2) | 2006-02-01 | Rollins et al. | Applicant |
| US7019838(B2) | 2006-03-01 | Izatt et al. | Applicant |
| US7027633(B2) | 2006-04-01 | Foran et al. | Applicant |
| US7061622(B2) | 2006-06-01 | Rollins et al. | Applicant |
| US7072047(B2) | 2006-07-01 | Westphal et al. | Applicant |
| US7075658(B2) | 2006-07-01 | Izatt et al. | Applicant |
| US7099358(B1) | 2006-08-01 | Chong et al. | Applicant |
| US7113288(B2) | 2006-09-01 | Fercher | Applicant |
| US7113625(B2) | 2006-09-01 | Watson et al. | Applicant |
| US7130320(B2) | 2006-10-01 | Tobiason et al. | Applicant |
| US7139598(B2) | 2006-11-01 | Hull et al. | Applicant |
| US7142835(B2) | 2006-11-01 | Paulus | Applicant |
| US7148970(B2) | 2006-12-01 | De Boer | Applicant |
| US7177027(B2) | 2007-02-01 | Hirasawa et al. | Applicant |
| US7190464(B2) | 2007-03-01 | Alphonse | Applicant |
| US7230708(B2) | 2007-06-01 | Lapotko et al. | Applicant |
| US7231243(B2) | 2007-06-01 | Tearney et al. | Applicant |
| US7236637(B2) | 2007-06-01 | Sirohey et al. | Applicant |
| US7242480(B2) | 2007-07-01 | Alphonse | Applicant |
| US7267494(B2) | 2007-09-01 | Deng et al. | Applicant |
| US7267930(B2) | 2007-09-01 | Payne | Applicant |
| US7272252(B2) | 2007-09-01 | De La Torre-Bueno et al. | Applicant |
| US7304798(B2) | 2007-12-01 | Izumi et al. | Applicant |
| US7310150(B2) | 2007-12-01 | Guillermo et al. | Applicant |
| US7330270(B2) | 2008-02-01 | O'Hara et al. | Applicant |
| US7336366(B2) | 2008-02-01 | Choma et al. | Applicant |
| US7342659(B2) | 2008-03-01 | Horn et al. | Applicant |
| US7355716(B2) | 2008-04-01 | De Boer et al. | Applicant |
| US7355721(B2) | 2008-04-01 | Quadling et al. | Applicant |
| US7359062(B2) | 2008-04-01 | Chen et al. | Applicant |
| US7365858(B2) | 2008-04-01 | Fang-Yen et al. | Applicant |
| US7366376(B2) | 2008-04-01 | Shishkov et al. | Applicant |
| US7382809(B2) | 2008-06-01 | Chong et al. | Applicant |
| US7391520(B2) | 2008-06-01 | Zhou et al. | Applicant |
| US7458683(B2) | 2008-12-01 | Chernyak et al. | Applicant |
| US7488117(B2) | 2009-02-01 | Chen | Applicant |
| US7530948(B2) | 2009-05-01 | Seibel et al. | Applicant |
| US7539530(B2) | 2009-05-01 | Caplan et al. | Applicant |
| US7609391(B2) | 2009-10-01 | Betzig | Applicant |
| US7630083(B2) | 2009-12-01 | de Boer et al. | Applicant |
| US7643152(B2) | 2010-01-01 | de Boer et al. | Applicant |
| US7643153(B2) | 2010-01-01 | de Boer et al. | Applicant |
| US7646905(B2) | 2010-01-01 | Guittet et al. | Applicant |
| US7649160(B2) | 2010-01-01 | Colomb et al. | Applicant |
| US7664300(B2) | 2010-02-01 | Lange et al. | Applicant |
| US7733497(B2) | 2010-06-01 | Yun et al. | Applicant |
| US7782464(B2) | 2010-08-01 | Mujat et al. | Applicant |
| US7799558(B1) | 2010-09-01 | Dultz | Applicant |
| US7805034(B2) | 2010-09-01 | Kato et al. | Applicant |
| US7911621(B2) | 2011-03-01 | Motaghiannezam et al. | Applicant |
| US7969578(B2) | 2011-06-01 | Yun et al. | Applicant |
| US7973936(B2) | 2011-07-01 | Dantus | Applicant |
| US8315282(B2) | 2012-11-01 | Huber et al. | Applicant |
| US9081148(B2) | 2015-07-01 | Tearney | Examiner |
| US2001/0020126(A1) | 2001-09-01 | Swanson et al. | Applicant |
| US2001/0036002(A1) | 2001-11-01 | Tearney et al. | Applicant |
| US2001/0047137(A1) | 2001-11-01 | Moreno et al. | Applicant |
| US2001/0055462(A1) | 2001-12-01 | Seibel | Applicant |
| US2002/0016533(A1) | 2002-02-01 | Marchitto et al. | Applicant |
| US2002/0024015(A1) | 2002-02-01 | Hoffmann et al. | Applicant |
| US2002/0037252(A1) | 2002-03-01 | Toida et al. | Applicant |
| US2002/0048025(A1) | 2002-04-01 | Takaoka | Applicant |
| US2002/0048026(A1) | 2002-04-01 | Isshiki et al. | Applicant |
| US2002/0052547(A1) | 2002-05-01 | Toida | Applicant |
| US2002/0057431(A1) | 2002-05-01 | Fateley et al. | Applicant |
| US2002/0064341(A1) | 2002-05-01 | Fauver et al. | Applicant |
| US2002/0076152(A1) | 2002-06-01 | Hughes et al. | Applicant |
| US2002/0085209(A1) | 2002-07-01 | Mittleman et al. | Applicant |
| US2002/0086347(A1) | 2002-07-01 | Johnson et al. | Applicant |
| US2002/0091322(A1) | 2002-07-01 | Chaiken et al. | Applicant |
| US2002/0093662(A1) | 2002-07-01 | Chen et al. | Applicant |
| US2002/0109851(A1) | 2002-08-01 | Deck | Applicant |
| US2002/0113965(A1) | 2002-08-01 | Roche et al. | Applicant |
| US2002/0122182(A1) | 2002-09-01 | Everett et al. | Applicant |
| US2002/0122246(A1) | 2002-09-01 | Tearney et al. | Applicant |
| US2002/0140942(A1) | 2002-10-01 | Fee et al. | Applicant |
| US2002/0158211(A1) | 2002-10-01 | Gillispie | Applicant |
| US2002/0161357(A1) | 2002-10-01 | Anderson et al. | Applicant |
| US2002/0163622(A1) | 2002-11-01 | Magnin et al. | Applicant |
| US2002/0166946(A1) | 2002-11-01 | Iizuka et al. | Applicant |
| US2002/0168158(A1) | 2002-11-01 | Furusawa et al. | Applicant |
| US2002/0172485(A1) | 2002-11-01 | Keaton et al. | Applicant |
| US2002/0183623(A1) | 2002-12-01 | Tang et al. | Applicant |
| US2002/0188204(A1) | 2002-12-01 | McNamara et al. | Applicant |
| US2002/0196446(A1) | 2002-12-01 | Roth et al. | Applicant |
| US2002/0198457(A1) | 2002-12-01 | Tearney et al. | Applicant |
| US2003/0001071(A1) | 2003-01-01 | Mandella et al. | Applicant |
| US2003/0013973(A1) | 2003-01-01 | Georgakoudi et al. | Applicant |
| US2003/0023153(A1) | 2003-01-01 | Izatt et al. | Applicant |
| US2003/0025917(A1) | 2003-02-01 | Suhami | Applicant |
| US2003/0026735(A1) | 2003-02-01 | Nolte et al. | Applicant |
| US2003/0028114(A1) | 2003-02-01 | Casscells, III et al. | Applicant |
| US2003/0030816(A1) | 2003-02-01 | Eom et al. | Applicant |
| US2003/0043381(A1) | 2003-03-01 | Fercher | Applicant |
| US2003/0053673(A1) | 2003-03-01 | Dewaele et al. | Applicant |
| US2003/0067607(A1) | 2003-04-01 | Wolleschensky et al. | Applicant |
| US2003/0082105(A1) | 2003-05-01 | Fischman et al. | Applicant |
| US2003/0097048(A1) | 2003-05-01 | Ryan et al. | Applicant |
| US2003/0103212(A1) | 2003-06-01 | Westphal et al. | Applicant |
| US2003/0108911(A1) | 2003-06-01 | Klimant et al. | Applicant |
| US2003/0120137(A1) | 2003-06-01 | Pawluczyk et al. | Applicant |
| US2003/0135101(A1) | 2003-07-01 | Webler | Applicant |
| US2003/0137669(A1) | 2003-07-01 | Rollins et al. | Applicant |
| US2003/0164952(A1) | 2003-09-01 | Deichmann et al. | Applicant |
| US2003/0165263(A1) | 2003-09-01 | Hamer et al. | Applicant |
| US2003/0171691(A1) | 2003-09-01 | Casscells, III et al. | Applicant |
| US2003/0174339(A1) | 2003-09-01 | Feldchtein et al. | Applicant |
| US2003/0191392(A1) | 2003-10-01 | Haldeman | Applicant |
| US2003/0199769(A1) | 2003-10-01 | Podoleanu et al. | Applicant |
| US2003/0216719(A1) | 2003-11-01 | Debenedictics et al. | Applicant |
| US2003/0218756(A1) | 2003-11-01 | Chen | Examiner |
| US2003/0220749(A1) | 2003-11-01 | Chen et al. | Applicant |
| US2003/0236443(A1) | 2003-12-01 | Cespedes et al. | Applicant |
| US2004/0002650(A1) | 2004-01-01 | Mandrusov et al. | Applicant |
| US2004/0039252(A1) | 2004-02-01 | Koch | Applicant |
| US2004/0039298(A1) | 2004-02-01 | Abreu | Applicant |
| US2004/0054268(A1) | 2004-03-01 | Esenaliev et al. | Applicant |
| US2004/0072200(A1) | 2004-04-01 | Rigler et al. | Applicant |
| US2004/0075841(A1) | 2004-04-01 | Van Neste et al. | Applicant |
| US2004/0076940(A1) | 2004-04-01 | Alexander et al. | Applicant |
| US2004/0077949(A1) | 2004-04-01 | Blofgett et al. | Applicant |
| US2004/0085540(A1) | 2004-05-01 | Lapotko et al. | Applicant |
| US2004/0086245(A1) | 2004-05-01 | Farroni et al. | Applicant |
| US2004/0095464(A1) | 2004-05-01 | Miyagi et al. | Applicant |
| US2004/0100631(A1) | 2004-05-01 | Bashkansky et al. | Applicant |
| US2004/0100681(A1) | 2004-05-01 | Bjarklev et al. | Applicant |
| US2004/0110206(A1) | 2004-06-01 | Wong et al. | Applicant |
| US2004/0119954(A1) | 2004-06-01 | Kawashima et al. | Applicant |
| US2004/0126048(A1) | 2004-07-01 | Dave et al. | Applicant |
| US2004/0126120(A1) | 2004-07-01 | Cohen et al. | Applicant |
| US2004/0133191(A1) | 2004-07-01 | Momiuchi et al. | Applicant |
| US2004/0150829(A1) | 2004-08-01 | Koch et al. | Applicant |
| US2004/0150830(A1) | 2004-08-01 | Chan | Applicant |
| US2004/0152989(A1) | 2004-08-01 | Puttappa et al. | Applicant |
| US2004/0165184(A1) | 2004-08-01 | Mizuno | Applicant |
| US2004/0166593(A1) | 2004-08-01 | Nolte et al. | Applicant |
| US2004/0188148(A1) | 2004-09-01 | Chen et al. | Applicant |
| US2004/0189999(A1) | 2004-09-01 | De Groot et al. | Applicant |
| US2004/0204651(A1) | 2004-10-01 | Freeman et al. | Applicant |
| US2004/0212808(A1) | 2004-10-01 | Okawa et al. | Applicant |
| US2004/0239938(A1) | 2004-12-01 | Izatt | Applicant |
| US2004/0246490(A1) | 2004-12-01 | Wang | Applicant |
| US2004/0246583(A1) | 2004-12-01 | Mueller et al. | Applicant |
| US2004/0247268(A1) | 2004-12-01 | Ishihara et al. | Applicant |
| US2004/0254474(A1) | 2004-12-01 | Seibel et al. | Applicant |
| US2004/0258106(A1) | 2004-12-01 | Araujo et al. | Applicant |
| US2004/0263843(A1) | 2004-12-01 | Knopp et al. | Applicant |
| US2005/0004453(A1) | 2005-01-01 | Tearney et al. | Applicant |
| US2005/0018133(A1) | 2005-01-01 | Huang et al. | Applicant |
| US2005/0018200(A1) | 2005-01-01 | Guillermo et al. | Applicant |
| US2005/0018201(A1) | 2005-01-01 | De Boer et al. | Applicant |
| US2005/0035295(A1) | 2005-02-01 | Bouma et al. | Applicant |
| US2005/0036150(A1) | 2005-02-01 | Izatt et al. | Applicant |
| US2005/0046837(A1) | 2005-03-01 | Izumi et al. | Applicant |
| US2005/0049488(A1) | 2005-03-01 | Homan | Applicant |
| US2005/0057680(A1) | 2005-03-01 | Agan | Applicant |
| US2005/0057756(A1) | 2005-03-01 | Fang-Yen et al. | Applicant |
| US2005/0059894(A1) | 2005-03-01 | Zeng et al. | Applicant |
| US2005/0065421(A1) | 2005-03-01 | Burckhardt et al. | Applicant |
| US2005/0075547(A1) | 2005-04-01 | Wang | Applicant |
| US2005/0083534(A1) | 2005-04-01 | Riza et al. | Applicant |
| US2005/0119567(A1) | 2005-06-01 | Choi et al. | Applicant |
| US2005/0128488(A1) | 2005-06-01 | Yelin et al. | Applicant |
| US2005/0165303(A1) | 2005-07-01 | Kleen et al. | Applicant |
| US2005/0171438(A1) | 2005-08-01 | Chen et al. | Applicant |
| US2005/0190372(A1) | 2005-09-01 | Dogariu et al. | Applicant |
| US2005/0197530(A1) | 2005-09-01 | Wallace et al. | Applicant |
| US2005/0221270(A1) | 2005-10-01 | Connelly et al. | Applicant |
| US2005/0254059(A1) | 2005-11-01 | Alphonse | Applicant |
| US2005/0254061(A1) | 2005-11-01 | Alphonse et al. | Applicant |
| US2006/0020172(A1) | 2006-01-01 | Luerssen et al. | Applicant |
| US2006/0033923(A1) | 2006-02-01 | Hirasawa et al. | Applicant |
| US2006/0039004(A1) | 2006-02-01 | De Boer et al. | Applicant |
| US2006/0093276(A1) | 2006-05-01 | Bouma et al. | Applicant |
| US2006/0103850(A1) | 2006-05-01 | Alphonse et al. | Applicant |
| US2006/0106375(A1) | 2006-05-01 | Werneth et al. | Applicant |
| US2006/0146339(A1) | 2006-07-01 | Fujita et al. | Applicant |
| US2006/0155193(A1) | 2006-07-01 | Leonardi et al. | Applicant |
| US2006/0164639(A1) | 2006-07-01 | Horn et al. | Applicant |
| US2006/0167363(A1) | 2006-07-01 | Bernstein et al. | Applicant |
| US2006/0171503(A1) | 2006-08-01 | O'Hara et al. | Applicant |
| US2006/0184048(A1) | 2006-08-01 | Saadat et al. | Applicant |
| US2006/0189928(A1) | 2006-08-01 | Camus et al. | Applicant |
| US2006/0193352(A1) | 2006-08-01 | Chong et al. | Applicant |
| US2006/0224053(A1) | 2006-10-01 | Black et al. | Applicant |
| US2006/0244973(A1) | 2006-11-01 | Yun et al. | Applicant |
| US2006/0279742(A1) | 2006-12-01 | Tearney | Applicant |
| US2007/0002435(A1) | 2007-01-01 | Ye et al. | Applicant |
| US2007/0019208(A1) | 2007-01-01 | Toida et al. | Applicant |
| US2007/0024860(A1) | 2007-02-01 | Tobiason et al. | Applicant |
| US2007/0035743(A1) | 2007-02-01 | Vakoc et al. | Applicant |
| US2007/0038040(A1) | 2007-02-01 | Cense et al. | Applicant |
| US2007/0048818(A1) | 2007-03-01 | Rosen et al. | Applicant |
| US2007/0070496(A1) | 2007-03-01 | Gweon et al. | Applicant |
| US2007/0076217(A1) | 2007-04-01 | Baker et al. | Applicant |
| US2007/0086013(A1) | 2007-04-01 | De Lega et al. | Applicant |
| US2007/0086017(A1) | 2007-04-01 | Buckland et al. | Applicant |
| US2007/0091317(A1) | 2007-04-01 | Freischlad et al. | Applicant |
| US2007/0133002(A1) | 2007-06-01 | Wax et al. | Applicant |
| US2007/0188855(A1) | 2007-08-01 | Shishkov et al. | Applicant |
| US2007/0203404(A1) | 2007-08-01 | Zysk et al. | Applicant |
| US2007/0208225(A1) | 2007-09-01 | Czaniera et al. | Applicant |
| US2007/0223006(A1) | 2007-09-01 | Tearney et al. | Applicant |
| US2007/0233056(A1) | 2007-10-01 | Yun | Applicant |
| US2007/0233396(A1) | 2007-10-01 | Tearney et al. | Applicant |
| US2007/0236700(A1) | 2007-10-01 | Yun et al. | Applicant |
| US2007/0253901(A1) | 2007-11-01 | Deng et al. | Applicant |
| US2007/0258094(A1) | 2007-11-01 | Izatt et al. | Applicant |
| US2007/0263226(A1) | 2007-11-01 | Kurtz et al. | Applicant |
| US2007/0291277(A1) | 2007-12-01 | Everett et al. | Applicant |
| US2008/0002197(A1) | 2008-01-01 | Sun et al. | Applicant |
| US2008/0007734(A1) | 2008-01-01 | Park et al. | Applicant |
| US2008/0013960(A1) | 2008-01-01 | Tearney et al. | Applicant |
| US2008/0021275(A1) | 2008-01-01 | Tearney et al. | Applicant |
| US2008/0049220(A1) | 2008-02-01 | Izzia et al. | Applicant |
| US2008/0070323(A1) | 2008-03-01 | Hess et al. | Applicant |
| US2008/0094613(A1) | 2008-04-01 | de Boer et al. | Applicant |
| US2008/0094637(A1) | 2008-04-01 | de Boer et al. | Applicant |
| US2008/0097225(A1) | 2008-04-01 | Tearney et al. | Applicant |
| US2008/0097709(A1) | 2008-04-01 | de Boer et al. | Applicant |
| US2008/0100837(A1) | 2008-05-01 | de Boer et al. | Applicant |
| US2008/0139906(A1) | 2008-06-01 | Bussek et al. | Applicant |
| US2008/0152353(A1) | 2008-06-01 | de Boer et al. | Applicant |
| US2008/0154090(A1) | 2008-06-01 | Hashimshony | Applicant |
| US2008/0192236(A1) | 2008-08-01 | Smith et al. | Applicant |
| US2008/0201081(A1) | 2008-08-01 | Reid | Applicant |
| US2008/0204762(A1) | 2008-08-01 | Izatt et al. | Applicant |
| US2008/0218696(A1) | 2008-09-01 | Mir | Applicant |
| US2008/0226029(A1) | 2008-09-01 | Weir et al. | Applicant |
| US2008/0228086(A1) | 2008-09-01 | Ilegbusi | Applicant |
| US2008/0234560(A1) | 2008-09-01 | Nomoto et al. | Applicant |
| US2008/0252901(A1) | 2008-10-01 | Shimizu | Applicant |
| US2008/0265130(A1) | 2008-10-01 | Colomb et al. | Applicant |
| US2008/0297806(A1) | 2008-12-01 | Motachiannezam | Applicant |
| US2008/0308730(A1) | 2008-12-01 | Vizi et al. | Applicant |
| US2009/0004453(A1) | 2009-01-01 | Murai et al. | Applicant |
| US2009/0005691(A1) | 2009-01-01 | Huang | Applicant |
| US2009/0011948(A1) | 2009-01-01 | Uniu et al. | Applicant |
| US2009/0012368(A1) | 2009-01-01 | Banik et al. | Applicant |
| US2009/0044799(A1) | 2009-02-01 | Bangsaruntip et al. | Applicant |
| US2009/0051923(A1) | 2009-02-01 | Zuluaga | Applicant |
| US2009/0131801(A1) | 2009-05-01 | Suter et al. | Applicant |
| US2009/0192358(A1) | 2009-07-01 | Jaffer et al. | Applicant |
| US2009/0196477(A1) | 2009-08-01 | Cense et al. | Applicant |
| US2009/0209834(A1) | 2009-08-01 | Fine | Applicant |
| US2009/0273777(A1) | 2009-11-01 | Yun et al. | Applicant |
| US2009/0281390(A1) | 2009-11-01 | Qiu et al. | Applicant |
| US2009/0290156(A1) | 2009-11-01 | Popescu et al. | Applicant |
| US2009/0305309(A1) | 2009-12-01 | Chien et al. | Applicant |
| US2009/0306520(A1) | 2009-12-01 | Schmitt et al. | Applicant |
| US2009/0323056(A1) | 2009-12-01 | Yun et al. | Applicant |
| US2010/0002241(A1) | 2010-01-01 | Hirose | Applicant |
| US2010/0086251(A1) | 2010-04-01 | Xu et al. | Applicant |
| US2010/0094576(A1) | 2010-04-01 | de Boer et al. | Applicant |
| US2010/0145145(A1) | 2010-06-01 | Shi et al. | Applicant |
| US2010/0150467(A1) | 2010-06-01 | Zhao et al. | Applicant |
| US2010/0220578(A1) | 2010-09-01 | Yamasaki et al. | Applicant |
| US2010/0261995(A1) | 2010-10-01 | Mckenna et al. | Applicant |
| US2011/0028967(A1) | 2011-02-01 | Rollins et al. | Applicant |
| US2011/0160681(A1) | 2011-06-01 | Dacey, Jr. et al. | Applicant |
| US2011/0218403(A1) | 2011-09-01 | Tearney et al. | Applicant |
| CN1550203 | 2004-12-01 | Applicant | |
| DE4105221 | 1991-09-01 | Applicant | |
| DE4309056 | 1994-09-01 | Applicant | |
| DE19542955 | 1997-05-01 | Applicant | |
| DE10351319 | 2005-06-01 | Applicant | |
| DE102005034443 | 2007-02-01 | Applicant | |
| EP110201 | 1984-06-01 | Applicant | |
| EP251062 | 1988-01-01 | Applicant | |
| EP617286 | 1994-02-01 | Applicant | |
| EP590268 | 1994-04-01 | Applicant | |
| EP697611 | 1996-02-01 | Applicant | |
| EP728440 | 1996-08-01 | Applicant | |
| EP933096 | 1999-08-01 | Applicant | |
| EP1324051 | 2003-07-01 | Applicant | |
| EP1426799 | 2004-06-01 | Applicant | |
| EP2149776 | 2010-02-01 | Applicant | |
| FR2738343 | 1995-08-01 | Applicant | |
| GB1257778 | 1971-12-01 | Applicant | |
| GB2030313 | 1980-04-01 | Applicant | |
| GB2209221 | 1989-05-01 | Applicant | |
| GB2298054 | 1996-08-01 | Applicant | |
| JP56-158304 | 1981-07-01 | Applicant | |
| JP6073405 | 1985-04-01 | Applicant | |
| JP361040633 | 1986-03-01 | Applicant | |
| JP62-188001 | 1989-06-01 | Applicant | |
| JP4-056907 | 1992-02-01 | Applicant | |
| JP20040056907 | 1992-02-01 | Applicant | |
| JP4135550 | 1992-05-01 | Applicant | |
| JP4135551 | 1992-05-01 | Applicant | |
| JP5509417 | 1993-11-01 | Applicant | |
| JPH8-136345 | 1996-05-01 | Applicant | |
| JPH08-160129 | 1996-06-01 | Applicant | |
| JPH08-166514 | 1996-06-01 | Applicant | |
| JP9-10213 | 1997-01-01 | Applicant | |
| JP9-230248 | 1997-09-01 | Applicant | |
| JP10-213485 | 1998-08-01 | Applicant | |
| JP10-267631 | 1998-10-01 | Applicant | |
| JP10-267830 | 1998-10-01 | Applicant | |
| JP2259617 | 1999-10-01 | Applicant | |
| JP2000-023978 | 2000-01-01 | Applicant | |
| JP2000-046729 | 2000-02-01 | Applicant | |
| JP2000-121961 | 2000-04-01 | Applicant | |
| JP2000-504234 | 2000-04-01 | Applicant | |
| JP2000-126116 | 2000-05-01 | Applicant | |
| JP2000-131222 | 2000-05-01 | Applicant | |
| JP2001-4447 | 2001-01-01 | Applicant | |
| JP2001-500026 | 2001-01-01 | Applicant | |
| JP2001-066245 | 2001-03-01 | Applicant | |
| JP2001-104315 | 2001-04-01 | Applicant | |
| JP2001-174404 | 2001-06-01 | Applicant | |
| JP2001-174744 | 2001-06-01 | Applicant | |
| JP2001-507251 | 2001-06-01 | Applicant | |
| JP2001-508340 | 2001-06-01 | Applicant | |
| JP2007-539336 | 2001-06-01 | Applicant | |
| JP2001-212086 | 2001-08-01 | Applicant | |
| JP2008-533712 | 2001-08-01 | Applicant | |
| JP2001-264246 | 2001-09-01 | Applicant | |
| JP2001-515382 | 2001-09-01 | Applicant | |
| JP2001-525580 | 2001-12-01 | Applicant | |
| JP2002-503134 | 2002-01-01 | Applicant | |
| JP2002-035005 | 2002-02-01 | Applicant | |
| JP2002-205434 | 2002-02-01 | Applicant | |
| JP2002-095663 | 2002-04-01 | Applicant | |
| JP2002-113017 | 2002-04-01 | Applicant | |
| JP2002-148185 | 2002-05-01 | Applicant | |
| JP2002-516586 | 2002-06-01 | Applicant | |
| JP2002-214127 | 2002-07-01 | Applicant | |
| JP2002-214128 | 2002-07-01 | Applicant | |
| JP2002214127 | 2002-07-01 | Applicant | |
| JP2002-221486 | 2002-08-01 | Applicant | |
| JP2003-014585 | 2003-01-01 | Applicant | |
| JP2003-504627 | 2003-02-01 | Applicant | |
| JP20030035659 | 2003-02-01 | Applicant | |
| JP2003-512085 | 2003-04-01 | Applicant | |
| JP2003-513278 | 2003-04-01 | Applicant | |
| JP2003-516531 | 2003-05-01 | Applicant | |
| JP2004-028970 | 2004-01-01 | Applicant | |
| JP2004-037165 | 2004-02-01 | Applicant | |
| JP2004-057652 | 2004-02-01 | Applicant | |
| JP2004-089552 | 2004-03-01 | Applicant | |
| JP2004-113780 | 2004-04-01 | Applicant | |
| JP2004-514920 | 2004-05-01 | Applicant | |
| JP2004-258144 | 2004-09-01 | Applicant | |
| JP2004-317437 | 2004-11-01 | Applicant | |
| JP2005-062850 | 2005-03-01 | Applicant | |
| JP2005-110208 | 2005-04-01 | Applicant | |
| JP2005-510323 | 2005-04-01 | Applicant | |
| JP2005-156540 | 2005-06-01 | Applicant | |
| JP2005-516187 | 2005-06-01 | Applicant | |
| JP2005-195485 | 2005-07-01 | Applicant | |
| JP2005-241872 | 2005-09-01 | Applicant | |
| JP2006-015134 | 2006-01-01 | Applicant | |
| JP2006-237359 | 2006-09-01 | Applicant | |
| JP2007-500059 | 2007-01-01 | Applicant | |
| JP2007-075403 | 2007-03-01 | Applicant | |
| JP2007-83053 | 2007-04-01 | Applicant | |
| JP2007-524455 | 2007-08-01 | Applicant | |
| JP2007271761 | 2007-10-01 | Applicant | |
| JP2003-102672 | 2012-04-01 | Applicant | |
| RU2149464 | 2000-05-01 | Applicant | |
| RU2209094 | 2003-07-01 | Applicant | |
| RU2213421 | 2003-09-01 | Applicant | |
| RU2242710 | 2004-12-01 | Applicant | |
| RU2255426 | 2005-06-01 | Applicant | |
| RU2108122 | 2006-06-01 | Applicant | |
| WO7900841 | 1979-10-01 | Applicant | |
| WO9201966 | 1992-02-01 | Applicant | |
| WO9216865 | 1992-10-01 | Applicant | |
| WO9219930 | 1992-11-01 | Applicant | |
| WO9303672 | 1993-03-01 | Applicant | |
| WO9533971 | 1995-12-01 | Applicant | |
| WO96-02184 | 1996-02-01 | Applicant | |
| WO96-04839 | 1996-02-01 | Applicant | |
| WO9628212 | 1996-09-01 | Applicant | |
| WO9732182 | 1997-09-01 | Applicant | |
| WO9800057 | 1998-01-01 | Applicant | |
| WO9801074 | 1998-01-01 | Applicant | |
| WO9814132 | 1998-04-01 | Applicant | |
| WO98-35203 | 1998-08-01 | Applicant | |
| WO9835203 | 1998-08-01 | Applicant | |
| WO9838907 | 1998-09-01 | Applicant | |
| WO9846123 | 1998-10-01 | Applicant | |
| WO9848838 | 1998-11-01 | Applicant | |
| WO9848846 | 1998-11-01 | Applicant | |
| WO9905487 | 1999-02-01 | Applicant | |
| WO9944089 | 1999-02-01 | Applicant | |
| WO99-28856 | 1999-06-01 | Applicant | |
| WO99-45838 | 1999-09-01 | Applicant | |
| WO9944089 | 1999-09-01 | Applicant | |
| WO99-45338 | 1999-10-01 | Applicant | |
| WO9957507 | 1999-11-01 | Applicant | |
| WO-42906 | 2000-07-01 | Applicant | |
| WO-43730 | 2000-07-01 | Applicant | |
| WO58766 | 2000-10-01 | Applicant | |
| WO1-04828 | 2001-01-01 | Applicant | |
| WO101111 | 2001-01-01 | Applicant | |
| WO108579 | 2001-02-01 | Applicant | |
| WO127679 | 2001-04-01 | Applicant | |
| WO1-33215 | 2001-05-01 | Applicant | |
| WO1-38820 | 2001-05-01 | Applicant | |
| WO138820 | 2001-05-01 | Applicant | |
| WO1-42735 | 2001-06-01 | Applicant | |
| WO142735 | 2001-06-01 | Applicant | |
| WO1-82786 | 2001-11-01 | Applicant | |
| WO2-37075 | 2002-05-01 | Applicant | |
| WO236015 | 2002-05-01 | Applicant | |
| WO237075 | 2002-05-01 | Applicant | |
| WO238040 | 2002-05-01 | Applicant | |
| WO2-45572 | 2002-06-01 | Applicant | |
| WO2-68853 | 2002-06-01 | Applicant | |
| WO2-054027 | 2002-07-01 | Applicant | |
| WO2053050 | 2002-07-01 | Applicant | |
| WO2054027 | 2002-07-01 | Applicant | |
| WO2-083003 | 2002-10-01 | Applicant | |
| WO2084263 | 2002-10-01 | Applicant | |
| WO3-003903 | 2003-01-01 | Applicant | |
| WO3-012405 | 2003-02-01 | Applicant | |
| WO3-013624 | 2003-02-01 | Applicant | |
| WO3013624 | 2003-02-01 | Applicant | |
| WO3020119 | 2003-03-01 | Applicant | |
| WO3046495 | 2003-06-01 | Applicant | |
| WO3046636 | 2003-06-01 | Applicant | |
| WO3052478 | 2003-06-01 | Applicant | |
| WO3053226 | 2003-07-01 | Applicant | |
| WO3062802 | 2003-07-01 | Applicant | |
| WO3/060423(A2) | 2003-07-01 | Applicant | |
| WO3-088826 | 2003-10-01 | Applicant | |
| WO3105678 | 2003-12-01 | Applicant | |
| WO2004034869 | 2004-04-01 | Applicant | |
| WO2004-037068 | 2004-05-01 | Applicant | |
| WO2004-043251 | 2004-05-01 | Applicant | |
| WO2004057266 | 2004-07-01 | Applicant | |
| WO2004066824 | 2004-08-01 | Applicant | |
| WO2004-073501 | 2004-09-01 | Applicant | |
| WO2004088361 | 2004-10-01 | Applicant | |
| WO2004-100789 | 2004-11-01 | Applicant | |
| WO2004-105598 | 2004-12-01 | Applicant | |
| WO2004105598 | 2004-12-01 | Applicant | |
| WO2005000115 | 2005-01-01 | Applicant | |
| WO2005-045362 | 2005-05-01 | Applicant | |
| WO2005-047813 | 2005-05-01 | Applicant | |
| WO2005047813 | 2005-05-01 | Applicant | |
| WO2005054780 | 2005-06-01 | Applicant | |
| WO2005082225 | 2005-09-01 | Applicant | |
| WO20050082225 | 2005-09-01 | Applicant | |
| WO2006004743 | 2006-01-01 | Applicant | |
| WO2006-020605 | 2006-02-01 | Applicant | |
| WO2006014392 | 2006-02-01 | Applicant | |
| WO2006038876 | 2006-04-01 | Applicant | |
| WO2006039091 | 2006-04-01 | Applicant | |
| WO2006-050320 | 2006-05-01 | Applicant | |
| WO2006-058187 | 2006-06-01 | Applicant | |
| WO2006059109 | 2006-06-01 | Applicant | |
| WO2006124860 | 2006-11-01 | Applicant | |
| WO2006-131859 | 2006-12-01 | Applicant | |
| WO2006130797 | 2006-12-01 | Applicant | |
| WO2006/133030 | 2006-12-01 | Applicant | |
| WO2007-030835 | 2007-03-01 | Applicant | |
| WO2007028531 | 2007-03-01 | Applicant | |
| WO2007038787 | 2007-04-01 | Applicant | |
| WO2007083138 | 2007-07-01 | Applicant | |
| WO2007084995 | 2007-07-01 | Applicant | |
| WO2009-033064 | 2009-03-01 | Applicant | |
| WO2009153929 | 2009-12-01 | Applicant | |
| WO2011-055376 | 2011-05-01 | Applicant | |
| WO2011-080713 | 2011-07-01 | Applicant |
Non-Patent Literature (1017)
- The Japanese Final Office Action for Japanese Applciation 2012-556285 dated Aug. 11, 2015.Applicant
- Poneros er al: “Optical Coherence Tomography of the Biliary Tree During ERCP”, Gastrointestinal Endoscopy, Elsevier, NL, vol. 55, No. 1, Jan. 1, 2002, pp. 84-88.Applicant
- Fu L e tal: Double-Clad Photonic Crystal Fiber Coupler for compact Nonlinear Optical Microscopy Imaging, Optics Letters, OSA, Optical Society of America, vol. 31, No. 10, May 15, 2006, pp. 1471-1473.Applicant
- Japanese language Appeal Decision dated Jan. 10, 2012 for JP 2006-503161.Applicant
- Japanese Notice of Grounds for Rejection dated Oct. 28, 2011 for JP2009-294737.Applicant
- Japanese Notice of Grounds for Rejection dated Dec. 28, 2011 for JP2008-535793.Applicant
- Japanese Notice of Reasons for Rejection dated Dec. 12, 2011 for JP 2008-533712.Applicant
- International Search Report and Written Opinion mailed Feb. 9, 2012 based on PCT/US2011/034810.Applicant
- Japanese Notice of Reasons for Rejection dated Mar. 27, 2012 for JP 2003-102672.Applicant
- Japanese Notice of Reasons for Rejection dated May 8, 2012 for JP 2008-533727.Applicant
- Korean Office Action dated May 25, 2012 for KR 10-2007-7008116.Applicant
- Japanese Notice of Reasons for Rejection dated May 21, 2012 for JP 2008-551523.Applicant
- Japanese Notice of Reasons for Rejection dated Jun. 20, 2012 for JP 2009-546534.Applicant
- European Official Communication dated Aug. 1, 2012 for EP 10193526.0.Applicant
- European Search Report dated Jun. 25, 2012 for EP 10733985.5.Applicant
- Wieser, Wolfgang et al., “Multi-Megahertz OCT: High Quality 3D Imaging at 20 million A-Scans and 4.5 Gvoxels Per Second” Jul. 5, 2010, vol. 18, No. 14, Optics Express.Applicant
- European Communication Pursuant to EPC Article 94(3) for EP 07845206.7 dated Aug. 30, 2012.Applicant
- International Search Report and Written Opinion mailed Aug. 30, 2012 for PCT/US2012/035234.Applicant
- Giuliano, Scarcelli et al., “Three-Dimensional Brillouin Confocal Microscopy”. Optical Society of American, 2007, CtuV5.Applicant
- Giuliano, Scarcelli et al., “Confocal Brillouin Microscopy for Three-Dimensional Mechanical Imaging.” Nat Photonis, Dec. 9, 2007.Applicant
- Japanese Notice of Reasons for Rejections dated Oct. 10, 2012 for 2008-553511.Applicant
- W.Y. Oh et al: “High-Speed Polarization Sensitive Optical Frequency Domain Imaging with Frequency Multiplexing”, Optics Express, vol. 16, No. 2, Jan. 1, 2008.Applicant
- Athey, B.D. et al., “Development and Demonstration of a Networked Telepathology 3-D Imaging, Databasing, and Communication System”, 1998 (“C2”), pp. 5-17.Applicant
- D'Amico, A.V., et al., “Optical Coherence Tomography as a Method for Identifying Benign and Maliganat Microscopic Structures in the Prostate Gland”, Urology, vol. 55, Isue 5, May 2000 (“C3”), pp. 783-787.Applicant
- Tearney, G.J. et al., “In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography”, vol. 276, No. 5321, Jun. 27, 1997 (“C6”), pp. 2037-2039.Applicant
- Japanese Notice of Reasons for Rejections dated Oct. 2, 2012 for 2007-543626.Applicant
- Canadian Office Action dated Oct. 10, 2012 for 2,514,189.Applicant
- Japanese Notice of Reasons for Rejections dated Nov. 9, 2012 for JP 2007-530134.Applicant
- Japanese Notice of Reasons for Rejections dated Nov. 27, 2012 for JP 2009-554772.Applicant
- Japanese Notice of Reasons for Rejections dated Oct. 11, 2012 for JP 2008-533712.Applicant
- Yoden, K. et al. “An Approach to Optical Reflection Tomography Along the Geometrial Thickness,” Optical Review, vol. 7, No. 5, Oct. 1, 2000.Applicant
- International Search Report and Written Opinion mailed Oct. 25, 2012 for PCT/US2012/047415.Applicant
- Joshua, Fox et al: “Measuring Primate RNFL Thickness with OCT”, IEEE Journal of Selected Topics in Quantum Electronics, IEEE Service Center, Piscataway, NJ, US, vol. 7,No. 6, Nov. 1, 2001.Applicant
- European Official Communication dated Feb. 6, 2013 for 04822169.1.Applicant
- International Search Report mailed Jan. 31, 2013 for PCT/US2012/061135.Applicant
- Viliyam K. Pratt. Lazernye Sistemy Svyazi. Moskva, Izdatelstvo “Svyaz”, 1972. p. 68-70.Applicant
- International Search Report and Written Opinion mailed Jan. 31, 2013 for PCT/US2012/060843.Applicant
- European Search Report mailed on Mar. 11, 2013 doe EP 10739129.4.Applicant
- Huber, R et al: “Fourier Domain Mode Locked Lasers for OCT Imaging at up to 290 kHz Sweep Rates”, Proceedings of SPIE, SPIE—International Society for Optical Engineering, US, vol. 5861, No. 1, Jan. 1, 2005.Applicant
- M. Kourogi et al: “Programmable High Speed (1MHz) Vernier-mode-locked Frequency-Swept Laser for OCT Imaging”, Proceedings of SPIE, vol. 6847, Feb. 7, 2008.Applicant
- Notice of Reasons for Rejection dated Feb. 5, 2013 for JP 2008-509233.Applicant
- Notice of Reasons for Rejection dated Feb. 19, 2013 for JP 2008-507983.Applicant
- European Extended Search Report mailed Mar. 26, 2013 for EP 09825421.1.Applicant
- Masahiro, Yamanari et al: “polarization-Sensitive Swept-Source Optical Coherence Tomography with Continuous Source Polarization Modulation”, Optics Express, vol. 16, No. 8, Apr. 14, 2008.Applicant
- European Extended Search Report mailed on Feb. 1, 2013 for EP 12171521.3.Applicant
- Nakamura, Koichiro et al., “A New Technique of Optical Ranging by a Frequency-Shifted Feedback Laser”, IEEE Phontonics Technology Letters, vol. 10, No. 12, pp. 1041-1135, Dec. 1998.Applicant
- Lee, Seok-Jeong et al., “Ultrahigh Scanning Speed Optical Coherence Tomography Using Optical Frequency Comb Generators”, The Japan Soceity of Applied Physics, vol. 40 (2001).Applicant
- Kinoshita, Masaya et al., “Optical Frequency-Domain Imaging Microprofilmetry with a Frequency-Tunable Liquid-Crystal Fbry-Perot Etalon Device” Applied Optics, vol. 38, No. 34, Dec. 1, 1999.Applicant
- Notice of Reasons for Rejection mailed on Apr. 16, 2013 for JP 2009-510092.Applicant
- Bachmann A.H. et al: “Heterodyne Fourier Domain Optical Coherence Tomography for Full Range Probing with High Axial Resolution”, Optics Express, OSA, vol. 14, No. 4, Feb. 20, 2006.Applicant
- European Search Report for 12194876.4 dated Feb. 1, 2013.Applicant
- International Search Report and Written Opinion for PCT/US2013/022136.Applicant
- Thomas J. Flotte: “Pathology Correlations with Optical Biopsy Techniques”, Annals of the New York Academy of Sciences, Wiley-Blackwell Publishing, Inc. SU, vol. 838, No. 1, Feb. 1, 1998, pp. 143-149.Applicant
- Constance R. Chu et al: Arthroscopic Microscopy of Articular Cartilage Using Optical Coherence Tomography, American Journal of Sports Medicine, American Orthopedic Society for Sports Medicine, Waltham, MA, Vo. 32, No. 9, Apr. 1, 2004.Applicant
- Bouma B E et al: Diagnosis of Specialized Intestinal Metaplasia of the Esophagus with Optical Coherence Tomography, Conference on Lasers and Electro-Optics. Technical Digest. OSA, US, vol. 56, May 6, 2001.Applicant
- Shen et al: “Ex Vivo Histology-Correlated Optical Coherence Tomography in the Detection of Transmural Inflammation in Crohn's Disease”, Clinical Gastroenterology and Heptalogy, vol. 2, No. 9, Sep. 1, 2004.Applicant
- Shen et al: “In Vivo Colonscopic Optical Coherence Tomography for Transmural Inflammation in Inflammatory Bowel Disease”, Clinical Gastroenterology and Hepatology, American Gastroenterological Association, US, vol. 2, No. 12, Dec. 1, 2004.Applicant
- Ge Z et al: “Identification of Colonic Dysplasia and Neoplasia by Diffuse Reflectance Spectroscopy and Pattern Recognition Techniques”, Applied Spectroscopy, The Society for Applied Spectroscopy, vol. 52, No. 6, Jun. 1, 1998.Applicant
- Elena Zagaynova et al: “Optical Coherence Tomography: Potentialities in Clinical Practice”, Proceedings of SPIE, Aug. 20, 2004.Applicant
- Westphal et al: “Correlation of Endoscopic Optical Coherence Tomography with Histology in the Lower-GI Tract”, Gastrointestinal Endoscopy, Elsevier, NL, vol. 61, No. 4, Apr. 1, 2005.Applicant
- Haggitt et al: “Barrett's Esophaagus, Dysplasia, and Adenocarcinoma”, Human Pathology, Saunders, Philadelphia, PA, US, vol. 25, No. 10, Oct. 1, 1994.Applicant
- Gang Yao et al. “Monte Carlo Simulation of an Optical Coherence Tomography Signal in Homogenous Turbid Media,” Physics in Medicine and Biology, 1999.Applicant
- Murakami, K. “A Miniature Confocal Optical Scanning Microscopy for Endscopes”, Proceedings of SPIE, vol. 5721, Feb. 28, 2005, pp. 119-131.Applicant
- Seok, H. Yun et al: “Comprehensive Volumetric Optical Microscopy in Vivo”, Nature Medicine, vol. 12, No. 12, Jan. 1, 2007.Applicant
- Baxter: “Image Zooming”, Jan. 25, 2005, Retrieved from the Internet.Applicant
- Qiang Zhou et al: “A Novel Machine Vision Application for Analysis and Visualization of Confocal Microscopic Images” Machine Vision and Applications, vol. 16, No. 2, Feb. 1, 2005.Applicant
- Igor Gurov et al: (2007) “Full-field High-Speed Optical Coherence Tomography System for Evaluting Multilayer and Random Tissues”, Proc. of SPIE, vol. 6618.Applicant
- Igor Gurov et al: “High-Speed Signal Evaluation in Optical Coherence Tomography Based on Sub-Nyquist Sampling and Kalman Filtering Method” AIP Coherence Proceedings, vol. 860, Jan. 1, 2006.Applicant
- Groot De P et al: “Three Dimensional Imaging by Sub-Nyquist Sampling of White-Light Interferograms”, Optics Letters, vol. 18, No. 17, Sep. 1, 1993.Applicant
- Silva et al: “Extended Range, Rapid Scanning Optical Delay Line for Biomedical Interferometric Imaging”, Electronics Letters, IEE Stevenage, GB vol. 35, No. 17, Aug. 19, 1999.Applicant
- European Search Report for European Patent Application No. 11751505.6 mailed on May 6, 2014.Applicant
- Office Commuciation for European Patent Application No. 11751505.6 mailed on May 23, 2014.Applicant
- Kye-Sung Lee et al, “Fourier domain optical . . . —depth-range probing”, Proceedings . . . Optical Engineering SPIE—Int. Soc. Opt. Eng. USA, vol. 6079; No. 1 pp. 607919-1-607919-8;2006.Applicant
- First Office Action for Japanese Patent Application No. 2012-556285 mailed on Nov. 25, 2014.Applicant
- Fujimoto et al., “High Resolution in Vivo Intra-Arterial Imaging with Optical Coherence Tomography,” Official Journal of the British Cardiac Society, vol. 82, pp. 128-133 Heart, 1999.Applicant
- D. Huang et al., “Optical Coherence Tomography,” Science, vol. 254, pp. 1178-1181, Nov. 1991.Applicant
- Tearney et al., “High-Speed Phase- and Group Delay Scanning with a Grating Based Phase Control Delay Line,” Optics Letters, vol. 22, pp. 1811-1813, Dec. 1997.Applicant
- Rollins, et al., “In Vivo Video Rate Optical Coherence Tomography,” Optics Express, vol. 3, pp. 219-229, Sep. 1998.Applicant
- Saxer, et al., High Speed Fiber-Based Polarization-Sensitive Optical Coherence Tomography of in Vivo Human Skin, Optical Society of America, vol. 25, pp. 1355-1357, Sep. 2000.Applicant
- Oscar Eduardo Martinez, “3000 Times Grating Compress or with Positive Group Velocity Dispersion,” IEEE, vol. QE-23, pp. 59-64, Jan. 1987.Applicant
- Kulkarni, et al., “Image Enhancement in Optical Coherence Tomography Using Deconvolution,” Electronics Letters, vol. 33, pp. 1365-1367, Jul. 1997.Applicant
- Bashkansky, et al., “Signal Processing for Improving Field Cross-Correlation Function in Optical Coherence Tomography,” Optics & Photonics News, vol. 9, pp. 8137-8138, May 1998.Applicant
- Yung et al., “Phase-Domain Processing of Optical Coherence Tomography Images,” Journal of Biomedical Optics, vol. 4, pp. 125-136, Jan. 1999.Applicant
- Tearney, et al., “In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography,” Science, vol. 276, Jun. 1997.Applicant
- W. Drexler et al., “In Vivo Ultrahigh-Resolution Optical Coherence Tomography,” Optics Letters vol. 24, pp. 1221-1223, Sep. 1999.Applicant
- Nicusor V. Iftimia et al., (2005) “A Portable, Low Coherence Interferometry Based Instrument for Fine Needle Aspiration Biopsy Guidance,” Accepted to Review of Scientific Instruments, published May 23, 2005.Applicant
- Abbas, G.L., V.W.S. Chan et al., “Local-Oscillator Excess-Noise Suppression for Homodyne and Heterodyne-Detection,” Optics Letters, vol. 8, pp. 419-421, Aug. 1983 issue.Applicant
- Agrawal, G.P., “Population Pulsations and Nondegenerate 4-Wave Mixing in Semiconductor-Lasers and Amplifiers,” Journal of the Optical Society of America B—Optical Physics, vol. 5, pp. 147-159, Jan. 1998.Applicant
- Andretzky, P. et al., “Optical Coherence Tomography by Spectral Radar: Improvement of Signal-to-Noise Ratio,” The International Society for Optical Engineering, USA, vol. 3915, 2000.Applicant
- Ballif, J. et al., “Rapid and Scalable Scans at 21 m/s in optical Low-Coherence Reflectometry,” Optics Letters, vol. 22, pp. 757-759, Jun. 1997.Applicant
- Barfuss H. et al., “Modified Optical Frequency-Domain Reflectometry with High Spatial-Resolution for Components of Integrated Optic Systems,” Journal of Lightwave Technology, vol. 7, pp. 3-10, Jan. 1989.Applicant
- Beaud, P. et al., “Optical Reflectometry with Micrometer Resolution for the Investigation of Integrated Optical-Devices,” Leee Journal of Quantum Electronics, vol. 25, pp. 755-759, Apr. 1989.Applicant
- Bouma, Brett et al., “Power-Efficient Nonreciprocal Interferometer and Linear-Scanning Fiber-Optic Catheter for Optical Coherence Tomography,” Optics Letters, vol. 24, pp. 531-533, Apr. 1999.Applicant
- Brinkmeyer, E. et al., “Efficient Algorithm for Non-Equidistant Interpolation of Sampled Data,” Electronics Letters, vol. 28, p. 693, Mar. 1992.Applicant
- Brinkmeyer, E. et al., “High-Resolution OCDR in Dispersive Wave-Guides,” Electronics Letters, vol. 26, pp. 413-414, Mar. 1990.Applicant
- Chinn, S.R. et al., “Optical Coherence Tomography Using a Frequency-Tunable Optical Source,” Optics Letters, vol. 22, pp. 340-342, Mar. 1997.Applicant
- Danielson, B.L. et al., “Absolute Optical Ranging Using Low Coherence Interferometry,” Applied Optics, vol. 30, p. 2975, Jul. 1991.Applicant
- Dorrer, C. et al., “Spectral Resolution and Sampling Issues in Fourier-Transform Spectral Interferometry,” Journal of the Optical Society of America B—Optical Physics, vol. 17, pp. 1795-1802, Oct. 2000.Applicant
- Dudley, J.M. et al., “Cross-Correlation Frequency Resolved Optical Gating Analysis of Broadband Continuum Generation in Photonic Crystal Fiber: Simulations and Experiments,” Optics Express, vol. 10, p. 1215, Oct. 2002.Applicant
- Eickhoff, W. et al., “Optical Frequency-Domain Reflectometry in Single-Mode Fiber,” Applied Physics Letters, vol. 39, pp. 693-695, 1981.Applicant
- Fercher, Adolf “Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 1, pp. 157-173, Apr. 1996.Applicant
- Ferreira, L.A. et al., “Polarization-Insensitive Fiberoptic White-Light Interferometry,” Optics Communications, vol. 114, pp. 386-392, Feb. 1995.Applicant
- Fujii, Yohji, “High-Isolation Polarization-Independent Optical Circulator”, Journal of Lightwave Technology, vol. 9, pp. 1239-1243, Oct. 1991.Applicant
- Glance, B., “Polarization Independent Coherent Optical Receiver,” Journal of Lightwave Technology, vol. LT-5, p. 274, Feb. 1987.Applicant
- Glombitza, U., “Coherent Frequency-Domain Reflectometry for Characterization of Single-Mode Integrated-Optical Wave-Guides,” Journal of Lightwave Technology, vol. 11, pp. 1377-1384, Aug. 1993.Applicant
- Golubovic, B. et al., “Optical Frequency-Domain Reflectometry Using Rapid Wavelength Tuning of a Cr4+:Forsterite Laser,” Optics Letters, vol. 11, pp. 1704-1706, Nov. 1997.Applicant
- Haberland, U. H. P. et al., “Chirp Optical Coherence Tomography of Layered Scattering Media,” Journal of Biomedical Optics, vol. 3, pp. 259-266, Jul. 1998.Applicant
- Hammer, Daniel X. et al., “Spectrally Resolved White-Light Interferometry for Measurement of Ocular Dispersion,” Journal of the Optical Society of America A—Optics Image Science and Vision, vol. 16, pp. 2092-2102, Sep. 1999.Applicant
- Harvey, K. C. et al., “External-Cavity Diode-Laser Using a Grazing-Incidence Diffraction Grating,” Optics Letters, vol. 16, pp. 910-912, Jun. 1991.Applicant
- Hausler, Gerd et al., “‘Coherence Radar’ and ‘Spectral Radar’ New Tools for Dermatological Diagnosis,” Journal of Biomedical Optics, vol. 3, pp. 21-31, Jan. 1998.Applicant
- Hee, Michael R. et al., “Polarization-Sensitive Low-Coherence Reflectometer for Birefringence Characterization and Ranging,” Journal of the Optical Society of America B (Optical Physics), vol. 9, p. 903-908, Jun. 1992.Applicant
- Hotate Kazuo et al., “Optical Coherence Domain Reflectometry by Synthesis of Coherence Function,” Journal of Lightwave Technology, vol. 11, pp. 1701-1710, Oct. 1993.Applicant
- Inoue, Kyo et al., “Nearly Degenerate 4-Wave-Mixing in a Traveling-Wave Semiconductor-Laser Amplifier,” Applied Physics Letters, vol. 51, pp. 1051-1053, 1987.Applicant
- Ivanov, A. P. et al., “New Method for High-Range Resolution Measurements of Light Scattering in Optically Dense Inhomogeneous Media,” Optics Letters, vol. 1, pp. 226-228, Dec. 1977.Applicant
- Ivanov, A. P. et al., “Interferometric Study of the Spatial Structure of a Light-Scattering Medium,” Journal of Applied Spectroscopy, vol. 28, pp. 518-525, 1978.Applicant
- Kazovsky, L. G. et al., “Heterodyne Detection Through Rain, Snow, and Turbid Media: Effective Receiver Size at Optical Through Millimeter Wavelenghths,” Applied Optics, vol. 22, pp. 706-710, Mar. 1983.Applicant
- Kersey, A. D. et al., “Adaptive Polarization Diversity Receiver Configuration for Coherent Optical Fiber Communications,” Electronics Letters, vol. 25, pp. 275-277, Feb. 1989.Applicant
- Kohlhaas, Andreas et al., “High-Resolution OCDR for Testing Integrated-Optical Waveguides: Dispersion-Corrupted Experimental Data Corrected by a Numerical Algorithm,” Journal of Lightwave Technology, vol. 9, pp. 1493-1502, Nov. 1991.Applicant
- Larkin, Kieran G., “Efficient Nonlinear Algorithm for Envelope Detection in White Light Interferometry,” Journal of the Optical Society of America A—Optics Image Science and Vision, vol. 13, pp. 832-843, Apr. 1996.Applicant
- Leitgeb, R. et al., “Spectral measurement of Absorption by Spectroscopic Frequency-Domain Optical Coherence Tomography,” Optics Letters, vol. 25, pp. 820-822, Jun. 2000.Applicant
- Lexer, F. et al., “Wavelength-Tuning Interferometry of Intraocular Distances,” Applied Optics, vol. 36, pp. 6548-6553, Sep. 1997.Applicant
- Mitsui, Takahisa, “Dynamic Range of Optical Reflectometry with Spectral Interferometry,” Japanese Journal of Applied Physics Part 1—Regular Papers Short Notes & Review Papers, vol. 38, pp. 6133-6137, 1999.Applicant
- Naganuma, Kazunori et al., “Group-Delay Measurement Using the Fourier-Transform of an Interferometric Cross-Correlation Generated by White Light,” Optics Letters, vol. 15, pp. 393-395, Apr. 1990.Applicant
- Okoshi,Takanori, “Polarization-State Control Schemes for Heterodyne or Homodyne Optical Fiber Communications,” Journal of Lightwave Technology, vol. LT-3, pp. 1232-1237, Dec. 1995.Applicant
- Passy, R. et al., “Experimental and Theoretical Investigations of Coherent OFDR with Semiconductor-Laser Sources,” Journal of Lightwave Technology, vol. 12, pp. 1622-1630, Sep. 1994.Applicant
- Podoleanu, Adrian G., “Unbalanced Versus Balanced Operation in an Optical Coherence Tomography System,” Applied Optics, vol. 39, pp. 173-182, Jan. 2000.Applicant
- Price, J. H. V. et al., “Tunable, Femtosecond Pulse Source Operating in the Range 1.06-1.33 mu m Based on an Yb3+-doped Holey Fiber Amplifier,” Journal of the Optical Society of America B—Optical Physics, vol. 19, pp. 1286-1294, Jun. 2002.Applicant
- Schmitt, J. M. et al, “Measurement of Optical-Properties of Biological Tissues by Low-Coherence Reflectometry,” Applied Optics, vol. 32, pp. 6032-6042, Oct. 1993.Applicant
- Silberberg, Y. et al., “Passive-Mode Locking of a Semiconductor Diode-Laser,” Optics Letters, vol. 9, pp. 507-509, Nov. 1984.Applicant
- Smith, L. Montgomery et al., “Absolute Displacement Measurements Using Modulation of the Spectrum of White-Light in a Michelson Interferometer,” Applied Optics, vol. 28, pp. 3339-3342, Aug. 1989.Applicant
- Sonnenschein, C. M. et al., “Signal-to-Noise Relationships for Coaxial Systems that Heterodyne Backscatter from Atmosphere,” Applied Optics, vol. 10, pp. 1600-1604, Jul. 1971.Applicant
- Sorin, W. V. et al., “Measurement of Rayleigh Backscattering at 1.55 mu m with 32 mu m Spatial Resolution,” IEEE Photonics Technology Letters, vol. 4, pp. 374-376, Apr. 1992.Applicant
- Sorin, W. V. et al., “A Simple Intensity Noise-Reduction Technique for Optical Low-Coherence Reflectometry,” IEEE Photonics Technology Letters, vol. 4, pp. 1404-1406, Dec. 1992.Applicant
- Swanson, E. A. et al., “High-Speed Optical Coherence Domain Reflectometry,” Optics Letters, vol. 17, pp. 151-153, Jan. 1992.Applicant
- Takada, K. et al., “High-Resolution OFDR with Incorporated Fiberoptic Frequency Encoder,” IEEE Photonics Technology Letters, vol. 4, pp. 1069-1072, Sep. 1992.Applicant
- Takada, Kazumasa et al., “Narrow-Band light Source with Acoustooptic Tunable Filter for Optical Low-Coherence Reflectometry,” IEEE Photonics Technology Letters, vol. 8, pp. 658-660, May 1996.Applicant
- Takada, Kazumasa et al., “New Measurement System for Fault Location in Optical Wave-Guide Devices Based on an Interometric-Technique,” Applied Optics, vol. 26, pp. 1603-1606, May 1987.Applicant
- Tateda, Mitsuhiro et al., “Interferometric Method for Chromatic Dispersion Measurement in a Single-Mode Optical Fiber,” IEEE Journal of Quantum Electronics, vol. 17, pp. 404-407, Mar. 1981.Applicant
- Toide, M. et al., “Two-Dimensional Coherent Detection Imaging in Multiple Scattering Media Based the Directional Resolution Capability of the Optical Heterodyne Method,” Applied Physics B (Photophysics and Laser Chemistry), vol. B52, pp. 391-394, 1991.Applicant
- Trutna, W. R. et al., “Continuously Tuned External-Cavity Semiconductor-Laser,” Journal of Lightwave Technology, vol. 11, pp. 1279-1286, Aug. 1993.Applicant
- Uttam, Deepak et al., “Precision Time Domain Reflectometry in Optical Fiber Systems Using a Frequency Modulated Continuous Wave Ranging Technique,” Journal of Lightwave Technology, vol. 3, pp. 971-977, Oct. 1985.Applicant
- Von Der Weid, J. P. et al., “On the Characterization of Optical Fiber Network Components with Optical Frequency Domain Reflectometry,” Journal of Lightwave Technology, vol. 15, pp. 1131-1141, Jul. 1997.Applicant
- Wysocki, P.F. et al., “Broad-Spectrum, Wavelength-Swept, Erbium-Doped Fiber Laser at 1.55-Mu-M,” Optics Letters, vol. 15, pp. 879-881, Aug. 1990.Applicant
- Youngquist, Robert C. et al., “Optical Coherence-Domain Reflectometry—A New Optical Evaluation Technique,” Optics Letters, vol. 12, pp. 158-160, Mar. 1987.Applicant
- Yun, S. H. et al., “Wavelength-Swept Fiber Laser with Frequency Shifted Feedback and Resonantly Swept Intra-Cavity Acoustooptic Tunable Filter,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 3, pp. 1087-1096, Aug. 1997.Applicant
- Yun, S. H. et al., “Interrogation of Fiber Grating Sensor Arrays with a Wavelength-Swept Fiber Laser,” Optics Letters, vol. 23, pp. 843-845, Jun. 1998.Applicant
- Yung, K. M., “Phase-Domain Processing of Optical Coherence Tomography Images,” Journal of Biomedical Optics, vol. 4, pp. 125-136, Jan. 1999.Applicant
- Zhou, Xiao-Qun et al., “Extended-Range FMCW Reflectometry Using an optical Loop with a Frequency Shifter,” IEEE Photonics Technology Letters, vol. 8, pp. 248-250, Feb. 1996.Applicant
- Zorabedian, Paul et al., “Tuning Fidelity of Acoustooptically Controlled External Cavity Semiconductor-Lasers” Journal of Lightwave Technology, vol. 13, pp. 62-66, Jan. 1995.Applicant
- Victor S. Y. Lin et al., “A Porous Silicon-Based Optical Interferometric Biosensor,” Science Magazine, vol. 278, pp. 840-843, Oct. 31, 1997.Applicant
- De Boer, Johannes F. et al., “Review of Polarization Sensitive Optical Coherence Tomography and Stokes Vector Determination,” Journal of Biomedical Optics, vol. 7, No. 3, Jul. 2002, pp. 359-371.Applicant
- Jiao, Shuliang et al., “Depth-Resolved Two-Dimensional Stokes Vectors of Backscattered Light and Mueller Matrices of Biological Tissue Measured with Optical Coherence Tomography,” Applied Optics, vol. 39, No. 34, Dec. 1, 2000, pp. 6318-6324.Applicant
- Park, B. Hyle et al., “In Vivo Burn Depth Determination by High-Speed Fiber-Based Polarization Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 6 No. 4, Oct. 2001, pp. 474-479.Applicant
- Roth, Jonathan E. et al., “Simplified Method for Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 26, No. 14, Jul. 15, 2001, pp. 1069-1071.Applicant
- Hitzenberger, Christopher K. et al., “Measurement and Imaging of Birefringence and Optic Axis Orientation by Phase Resolved Polarization Sensitive Optical Coherence Tomography,” Optics Express, vol. 9, No. 13, Dec. 17, 2001, pp. 780-790.Applicant
- Wang, Xuedong et al., (2001) “Propagation of Polarized Light in Birefringent Turbid Media: Time-Resolved Simulations,” Optical Imaging Laboratory, Biomedical Engineering Program, Texas A&M University, Aug. 27, 2001, pp. 254-259.Applicant
- Wong, Brian J.F. et al., “Optical Coherence Tomography of the Rat Cochlea,” Journal of Biomedical Optics, vol. 5, No. 4, Oct. 2000, pp. 367-370.Applicant
- Yao, Gang et al., “Propagation of Polarized Light in Turbid Media: Simulated Animation Sequences,” Optics Express, vol. 7, No. 5, Aug. 28, 2000, pp. 198-203.Applicant
- Wang, Xiao-Jun et al., “Characterization of Dentin and Enamel by Use of Optical Coherence Tomography,” Applied Optics, vol. 38, No. 10, Apr. 1, 1999, pp. 2092-2096.Applicant
- De Boer, Johannes F. et al., “Determination of the Depth-Resolved Stokes Parameters of Light Backscattered from Turbid Media by use of Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 24, No. 5, Mar. 1, 1999, pp. 300-302.Applicant
- Ducros, Mathieu G. et al., “Polarization Sensitive Optical Coherence Tomography of the Rabbit Eye,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, No. 4, Jul./Aug. 1999, pp. 1159-1167.Applicant
- Groner, Warren et al., “Orthogonal Polarization Spectral Imaging: A New Method for Study of the Microcirculation,” Nature Medicine Inc., vol. 5 No. 10, Oct. 1999, pp. 1209-1213.Applicant
- De Boer, Johannes F. et al., “Polarization Effects in Optical Coherence Tomography of Various Viological Tissues,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, No. 4, Jul./Aug. 1999, pp. 1200-1204.Applicant
- Yao, Gang et al., “Two-Dimensional Depth-Resolved Mueller Matrix Characterization of Biological Tissue by Optical Coherence Tomography,” Optics Letters, Apr. 15, 1999, vol. 24, No. 8, pp. 537-539.Applicant
- Lu, Shih-Yau et al., “Homogeneous and Inhomogeneous Jones Matrices,” J. Opt. Soc. Am. A., vol. 11, No. 2, Feb. 1994, pp. 766-773.Applicant
- Bickel, S. William et al., “Stokes Vectors, Mueller Matrices, and Polarized Scattered Light,” Am. J. Phys., vol. 53, No. 5, May 1985 pp. 468-478.Applicant
- Bréhonnet, F. Le Roy et al., “Optical Media and Target Characterization by Mueller Matrix Decomposition,” J. Phys. D: Appl. Phys. 29, 1996, pp. 34-38.Applicant
- Cameron, Brent D. et al., “Measurement and Calculation of the Two-Dimensional Backscattering Mueller Matrix of a Turbid Medium,” Optics Letters, vol. 23, No. 7, Apr. 1, 1998, pp. 485-487.Applicant
- De Boer, Johannes F. et al., “Two-Dimensional Birefringence Imaging in Biological Tissue by Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 22, No. 12, Jun. 15, 1997, pp. 934-936.Applicant
- De Boer, Johannes F. et al., “Imaging Thermally Damaged Tissue by Polarization Sensitive Optical Coherence Tomography,” Optics Express, vol. 3, No. 6, Sep. 14, 1998, pp. 212-218.Applicant
- Everett, M.J. et al., “Birefringence Characterization of Biological Tissue by Use of Optical Coherence Tomography,” Optics Letters, vol. 23, No. 3, Feb. 1, 1998, pp. 228-230.Applicant
- Hee, Michael R. et al., “Polarization-Sensitive Low-Coherence Reflectometer for Birefringence Characterization and Ranging,” J. Opt. Soc. Am. B., vol. 9, No. 6, Jun. 1992, pp. 903-908.Applicant
- Barakat, Richard, “Statistics of the Stokes Parameters,” J. Opt. Soc. Am. B., vol. 4, No. 7, Jul. 1987, pp. 1256-1263.Applicant
- Schmitt, J.M. et al., “Cross-Polarized Backscatter in Optical Coherence Tomography of Biological Tissue,” Optics Letters, vol. 23, No. 13, Jul. 1, 1998, pp. 1060-1062.Applicant
- Schoenenberger, Klaus et al., “Mapping Birefringence and Thermal Damage in Tissue by use of Polarization-Sensitive Optical Coherence Tomography,” Applied Optics, vol. 37, No. 25, Sep. 1, 1998, pp. 6026-6036.Applicant
- Pierce, Mark C. et al., “Simultaneous Intensity, Birefringence, and Flow Measurements with High-Speed Fiber-Based Optical Coherence Tomography,” Optics Letters, vol. 27, No. 17, Sep. 1, 2002, pp. 1534-1536.Applicant
- De Boer, Johannes F. et al., “Review of Polarization Sensitive Optical Coherence Tomography and Stokes Vector Determination,” Journal of Biomedical Optics, Jul. 2002, vol. 7, No. 3, pp. 359-371.Applicant
- Fried, Daniel et al., “Imaging Caries Lesions and Lesion Progression with Polarization Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 7, No. 4, Oct. 2002, pp. 618-627.Applicant
- Jiao, Shuliang et al., “Two-Dimensional Depth-Resolved Mueller Matrix of Biological Tissue Measured with Double-Beam Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 27, No. 2, Jan. 15, 2002, pp. 101-103.Applicant
- Jiao, Shuliang et al., “Jones-Matrix Imaging of Biological Tissues with Quadruple-Channel Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 7, No. 3, Jul. 2002, pp. 350-358.Applicant
- Kuranov, R.V. et al., “Complementary Use of Cross-Polarization and Standard OCT for Differential Diagnosis of Pathological Tissues,” Optics Express, vol. 10, No. 15, Jul. 29, 2002, pp. 707-713.Applicant
- Cense, Barry et al., “In Vivo Depth-Resolved Birefringence Measurements of the Human Retinal Nerve Fiber Layer by Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 27, No. 18, Sep. 15, 2002, pp. 1610-1612.Applicant
- Ren, Hongwu et al., “Phase-Resolved Functional Optical Coherence Tomography: Simultaneous Imaging of In Situ Tissue Structure, Blood Flow Velocity, Standard Deviation, Birefringence, and Stokes Vectors in Human Skin,” Optics Letters, vol. 27, No. 19, Oct. 1, 2002, pp. 1702-1704.Applicant
- Tripathi, Renu et al., “Spectral Shaping for Non-Gaussian Source Spectra in Optical Coherence Tomography,” Optics Letters, vol. 27, No. 6, Mar. 15, 2002, pp. 406-408.Applicant
- Yasuno, Y. et al., “Birefringence Imaging of Human Skin by Polarization-Sensitive Spectral Interferometric Optical Coherence Tomography,” Optics Letters, vol. 27, No. 20, Oct. 15, 2002 pp. 1803-1805.Applicant
- White, Brian R. et al., “In Vivo Dynamic Human Retinal Blood Flow Imaging Using Ultra-High-Speed Domain Optical Doppler Tomography,” Optics Express, vol. 11, No. 25, Dec. 15, 2003, pp. 3490-3497.Applicant
- De Boer, Johannes F. et al., “Improved Signal-to-Noise Ratio in Spectral-Domain Compared with Time-Domain Optical Coherence Tomography,” Optics Letters, vol. 28, No. 21, Nov. 1, 2003, pp. 2067-2069.Applicant
- Jiao, Shuliang et al., “Optical-Fiber-Based Mueller Optical Coherence Tomography,” Optics Letters, vol. 28, No. 14, Jul. 15, 2003, pp. 1206-1208.Applicant
- Jiao, Shuliang et al., “Contrast Mechanisms in Polarization-Sensitive Mueller-Matrix Optical Coherence Tomography and Application in Burn Imaging,” Applied Optics, vol. 42, No. 25, Sep. 1, 2003, pp. 5191-5197.Applicant
- Moreau, Julien et al., “Full-Field Birefringence Imaging by Thermal-Light Polarization-Sensitive Optical Coherence Tomography. I. Theory,” Applied Optics, vol. 42, No. 19, Jul. 1, 2003, pp. 3800-3810.Applicant
- Moreau, Julien et al., “Full-Field Birefringence Imaging by Thermal-Light Polarization-Sensitive Optical Coherence Tomography. II. Instrument and Results,” Applied Optics, vol. 42, No. 19, Jul. 1, 2003, pp. 3811-3818.Applicant
- Morgan, Stephen P. et al., “Surface-Reflection Elimination in Polarization Imaging of Superficial Tissue,” Optics Letters, vol. 28, No. 2, Jan. 15, 2003, pp. 114-116.Applicant
- Oh, Jung-Taek et al., “Polarization-Sensitive Optical Coherence Tomography for Photoelasticity Testing of Glass/Epoxy Composites,” Optics Express, vol. 11, No. 14, Jul. 14, 2003, pp. 1669-1676.Applicant
- Park, B. Hyle et al., “Real-Time Multi-Functional Optical Coherence Tomography,” Optics Express, vol. 11, No. 7, Apr. 7, 2003, pp. 782-793.Applicant
- Shribak, Michael et al., “Techniques for Fast and Sensitive Measurements of Two-Dimensional Birefringence Distributions,” Applied Optics, vol. 42, No. 16, Jun. 1, 2003, pp. 3009-3017.Applicant
- Somervell, A.R.D. et al., “Direct Measurement of Fringe Amplitude and Phase Using a Heterodyne Interferometer Operating in Broadband Light,” Elsevier, Optics Communications, Oct. 2003.Applicant
- Stifter, D. et al., “Polarisation-Sensitive Optical Coherence Tomography for Material Characterisation and Strain-Field Mapping,” Applied Physics A 76, Materials Science & Processing, Jan. 2003, pp. 947-951.Applicant
- Davé, Digant P. et al., “Polarization-Maintaining Fiber-Based Optical Low-Coherence Reflectometer for Characterization and Ranging of Birefringence,” Optics Letters, vol. 28, No. 19, Oct. 1, 2003, pp. 1775-1777.Applicant
- Yang, Ying et al., “Observations of Birefringence in Tissues from Optic-Fibre-Based Optical Coherence Tomography,” Measurement Science and Technology, Nov. 2002, pp. 41-46.Applicant
- Yun, S.H. et al., “High-Speed Optical Frequency-Domain Imaging,” Optics Express, vol. 11, No. 22, Nov. 3, 2003, pp. 2953-2963.Applicant
- Yun, S.H. et al., “High-Speed Spectral-Domain Optical Coherence Tomography at 1.3 μm Wavelength,” Optics Express, vol. 11, No. 26, Dec. 29, 2003, pp. 3598-3604.Applicant
- Zhang, Jun et al., “Determination of Birefringence and Absolute Optic Axis Orientation Using Polarization-Sensitive Optical Coherence Tomography with PM Fibers,” Optics Express, vol. 11, No. 24, Dec. 1, 2003, pp. 3262-3270.Applicant
- Pircher, Michael et al., “Three Dimensional Polarization Sensitive OCT of Human Skin In Vivo,” 2004, Optical Society of America.Applicant
- Götzinger, Erich et al., “Measurement and Imaging of Birefringent Properties of the Human Cornea with Phase-Resolved, Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 94-102.Applicant
- Guo, Shuguang et al., “Depth-Resolved Birefringence and Differential Optical Axis Orientation Measurements with Finer-based Polarization-Sensitive Optical Coherence Tomography,” Optics Letters, vol. 29, No. 17, Sep. 1, 2004, pp. 2025-2027.Applicant
- Huang, Xiang-Run et al.,“Variation of Peripapillary Retinal Nerve Fiber Layer Birefringence in Normal Human Subjects,” Investigative Ophthalmology & Visual Science, vol. 45, No. 9, Sep. 2004, pp. 3073-3080.Applicant
- Matcher, Stephen J. et al., “The Collagen Structure of Bovine Intervertebral Disc Studied Using Polarization-Sensitive Optical Coherence Tomography,” Physics in Medicine and Biology, 2004, pp. 1295-1306.Applicant
- Nassif, Nader et al., “In Vivo Human Retinal Imaging by Ultrahigh-Speed Spectral Domain Optical Coherence Tomography,” Optics Letters, vol. 29, No. 5, Mar. 1, 2004, pp. 480-482.Applicant
- Nassif, N.A. et al., “In Vivo High-Resolution Video-Rate Spectral-Domain Optical Coherence Tomography of the Human Retina and Optic Nerve,” Optics Express, vol. 12, No. 3, Feb. 9, 2004, pp. 367-376.Applicant
- Park, B. Hyle et al., Comment on “Optical-Fiber-Based Mueller Optical Coherence Tomography,” Optics Letters, vol. 29, No. 24, Dec. 15, 2004, pp. 2873-2874.Applicant
- Park, B. Hyle et al., “Jones Matrix Analysis for a Polarization-Sensitive Optical Coherence Tomography System Using Fiber-Optic Components,” Optics Letters, vol. 29, No. 21, Nov. 1, 2004, pp. 2512-2514.Applicant
- Pierce, Mark C. et al., “Collagen Denaturation can be Quantified in Burned Human Skin Using Polarization-Sensitive Optical Coherence Tomography,” Elsevier, Burns, 2004, pp. 511-517.Applicant
- Pierce, Mark C. et al., “Advances in Optical Coherence Tomography Imaging Dermatology,” The Society for Investigative Dermatology, Inc. 2004, pp. 458-463.Applicant
- Pierce, Mark C. et al., “Birefringence Measurements in Human Skin Using Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 2, Mar./Apr. 2004, pp. 287-291.Applicant
- Cense, Barry et al., “In Vivo Firefringence and Thickness Measurements of the Human Retinal Nerve Fiber Layer Using Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 121-125.Applicant
- Pircher, Michael et al., “Imaging of Polarization Properties of Human Retina in Vivo with Phase Resolved Transversal PS-OCT,” Optics Express, vol. 12, No. 24, Nov. 29, 2004 pp. 5940-5951.Applicant
- Pircher, Michael et al., “Transversal Phase Resolved Polarization Sensitive Optical Coherence Tomography,” Physics in Medicine & Biology, 2004, pp. 1257-1263.Applicant
- Srinivas, Shyam M. et al., “Determination of Burn Depth by Polarization-Sensitive Optical Coherence Tomography,” Journal of Biomedical Optics, vol. 9, No. 1, Jan./Feb. 2004, pp. 207-212.Applicant
- Strasswimmer, John et al., “Polarization-Sensitive Optical Coherence Tomography of Invasive Basal Cell Carcinoma,” Journal of Biomedical Optics, vol. 9, No. 2, Mar./Apr. 2004, pp. 292-298.Applicant
- Todorovi{hacek over (c)}, Milo{hacek over (s)} et al., “Determination of Local Polarization Properties of Biological Samples in the Presence of Diattenuation by use of Mueller Optical Coherence Tomography,” Optics Letters, vol. 29, No. 20, Oct. 15, 2004, pp. 2402-2404.Applicant
- Yasuno, Yoshiaki et al., “Polarization-Sensitive Complex Fourier Domain Optical Coherence Tomography for Jones Matrix Imaging of Biological Samples,” Applied Physics Letters, vol. 85, No. 15, Oct. 11, 2004, pp. 3023-3025.Applicant
- Acioli, L. H., M. Ulman, et al. (1991). “Femtosecond Temporal Encoding in Barium-Titanate.” Optics Letters 16(24): 1984-1986.Applicant
- Aigouy, L., A. Lahrech, et al. (1999). “Polarization effects in apertureless scanning near-field optical microscopy: an experimental study.” Optics Letters 24(4): 187-189.Applicant
- Akiba, M., K. P. Chan, et al. (2003). “Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras.” Optics Letters 28(10): 816-818.Applicant
- Akkin, T., D. P. Dave, et al. (2004). “Detection of neural activity using phase-sensitive optical low-coherence reflectometry.” Optics Express 12(11): 2377-2386.Applicant
- Akkin, T., D. P. Dave, et al. (2003). “Surface analysis using phase sensitive optical low coherence reflectometry.” Lasers in Surgery and Medicine: 4-4.Applicant
- Akkin, T., D. P. Dave, et al. (2003). “Imaging tissue response to electrical and photothermal stimulation with nanometer sensitivity.” Lasers in Surgery and Medicine 33(4): 219-225.Applicant
- Akkin, T., T. E. Milner, et al. (2002). “Phase-sensitive measurement of birefringence change as an indication of neural functionality and diseases.” Lasers in Surgery and Medicine: 6-6.Applicant
- Andretzky, P., Lindner, M.W., Herrmann, J.M., Schultz, A., Konzog, M., Kiesewetter, F., Haeusler, G. (1999). “Optical coherence tomography by ‘spectral radar’: Dynamic range estimation and in vivo measurements of skin.” Proceedings of SPIE—The International Society for Optical Engineering 3567: pp. 78-87.Applicant
- Antcliff, R. J., T. J. ffytche, et al. (2000). “Optical coherence tomography of melanocytoma.” American Journal of Ophthalmology 130(6): 845-7.Applicant
- Antcliff, R. J., M. R. Stanford, et al. (2000). “Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patient with uveitis.” Ophthalmology 107(3): 593-9.Applicant
- Anvari, B., T. E. Milner, et al. (1995). “Selective Cooling of Biological Tissues—Application for Thermally Mediated Therapeutic Procedures.” Physics in Medicine and Biology 40(2): 241-252.Applicant
- Anvari, B., B. S. Tanenbaum, et al. (1995). “A Theoretical-Study of the Thermal Response of Skin to Cryogen Spray Cooling and Pulsed-Laser Irradiation—Implications for Treatment of Port-Wine Stain Birthmarks.” Physics in Medicine and Biology 40(9): 1451-1465.Applicant
- Arend, O., M. Ruffer, et al. (2000). “Macular circulation in patients with diabetes mellitus with and without arterial hypertension.” British Journal of Ophthalmology 84(12): 1392-1396.Applicant
- Arimoto, H. and Y. Ohtsuka (1997). “Measurements of the complex degree of spectral coherence by use of a wave-front-folded interferometer.” Optics Letters 22(13): 958-960.Applicant
- Azzolini, C., F. Patelli, et al. (2001). “Correlation between optical coherence tomography data and biomicroscopic interpretation of idiopathic macular hole.” American Journal of Ophthalmology 132(3): 348-55.Applicant
- Baba, T., K. Ohno-Matsui, et al. (2002). “Optical coherence tomography of choroidal neovascularization in high myopia.” Acta Ophthalmoloqica Scandinavica 80(1): 82-7.Applicant
- Bail, M. A. H., Gerd; Herrmann, Juergen M.; Lindner, Michael W.; Ringler, R. (1996). “Optical coherence tomography with the “spectral radar”: fast optical analysis in volume scatterers by short-coherence interferometry.” Proc. SPIE, 2925: p. 298-303.Applicant
- Baney, D. M. and W. V. Sorin (1993). “Extended-Range Optical Low-Coherence Reflectometry Using a Recirculating Delay Technique.” Ieee Photonics Technology Letters 5(9): 1109-1112.Applicant
- Baney, D. M., B. Szafraniec, et al. (2002). “Coherent optical spectrum analyzer.” Ieee Photonics Technology Letters 14(3): 355-357.Applicant
- Barakat, R. (1981). “Bilinear Constraints between Elements of the 4by4 Mueller-Jones Transfer-Matrix of Polarization Theory.” Optics Communications 38(3): 159-161.Applicant
- Barakat, R. (1993). “Analytic Proofs of the Arago-Fresnel Laws for the Interference of Polarized-Light.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(1): 180-185.Applicant
- Barbastathis, G. and D. J. Brady (1999). “Multidimensional tomographic imaging using volume holography.” Proceedings of the leee 87(12): 2098-2120.Applicant
- Bardal, S., A. Kamal, et al. (1992). “Photoinduced Birefringence in Optical Fibers—a Comparative-Study of Low-Birefringence and High-Birefringence Fibers.” Optics Letters 17(6): 411-413.Applicant
- Barsky, S. H., S. Rosen, et al. (1980). “Nature and Evolution of Port Wine Stains—Computer-Assisted Study.” Journal of Investigative Dermatology 74(3): 154-157.Applicant
- Barton, J. K., J. A. Izatt, et al. (1999). “Three-dimensional reconstruction of blood vessels from in vivo color Doppler optical coherence tomography images.” Dermatology 198(4): 355-361.Applicant
- Barton, J. K., A. Rollins, et al. (2001). “Photothermal coagulation of blood vessels: a comparison of high-speed optical coherence tomography and numerical modelling.” Physics in Medicine and Biology 46.Applicant
- Barton, J. K., A. J. Welch, et al. (1998). “Investigating pulsed dye laser-blood vessel interaction with color Doppler optical coherence tomography.” Optics Express 3.Applicant
- Bashkansky, M., M. D. Duncan, et al. (1997). “Subsurface defect detection in ceramics by high-speed high-resolution optical coherent tomography.” Optics Letters 22 (1): 61-63.Applicant
- Bashkansky, M. and J. Reintjes (2000). “Statistics and reduction of speckle in optical coherence tomography.” Optics Letters 25(8): 545-547.Applicant
- Baumgartner, A., S. Dichtl, et al. (2000). “Polarization-sensitive optical coherence tomography of dental structures.” Caries Research 34(1): 59-69.Applicant
- Baumgartner, A., C. K. Hitzenberger, et al. (2000). “Resolution-improved dual-beam and standard optical coherence tomography: a comparison.” Graefes Archive for Clinical and Experimental Ophthalmology 238(5): 385-392.Applicant
- Baumgartner, A., C. K. Hitzenberger, et al. (1998). “Signal and resolution enhancements in dual beam optical coherence tomography of the human eye.” Journal of Biomedical Optics 3(1): 45-54.Applicant
- Beaurepaire, E., P. Gleyzes, et at. (1998). Optical coherence microscopy for the in-depth study of biological structures: System based on a parallel detection scheme, Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Beaurepaire, E., L. Moreaux, et al. (1999). “Combined scanning optical coherence and two-photon-excited fluorescence microscopy.” Optics Letters 24(14): 969-971.Applicant
- Bechara, F. G., T. Gambichler, et al. (2004). “Histomorphologic correlation with routine histology and optical coherence tomography.” Skin Research and Technology 10 (3): 169-173.Applicant
- Bechmann, M., M. J. Thiel, et al. (2000). “Central corneal thickness determined with optical coherence tomography in various types of glaucoma. [see comments].” British Journal of Ophthalmology 84(11): 1233-7.Applicant
- Bek, T. and M. Kandi (2000). “Quantitative anomaloscopy and optical coherence tomography scanning in central serous chorioretinopathy.” Acta Ophthalmologica Scandinavica 78(6): 632-7.Applicant
- Benoit, A. M., K. Naoun, et al. (2001). “Linear dichroism of the retinal nerve fiber layer expressed with Mueller matrices.” Applied Optics 40(4): 565-569.Applicant
- Bicout, D., C. Brosseau, et al. (1994). “Depolarization of Multiply Scattered Waves by Spherical Diffusers—Influence of the Size Parameter.” Physical Review E 49(2): 1767-1770.Applicant
- Blanchot, L., M. Lebec, et al. (1997). Low-coherence in depth microscopy for biological tissues imaging: Design of a real time control system. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Blumenthal, E. Z. and R. N. Weinreb (2001). “Assessment of the retinal nerve fiber layer in clinical trials of glaucoma neuroprotection. [Review] [36 refs].” Survey of Ophthalmology 45(Suppl 3): S305-12; discussion S332-4.Applicant
- Blumenthal, E. Z., J. M. Williams, et al. (2000). “Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography.” Ophthalmology 107(12): 2278-82.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1996). “Imaging developing neural morphology using optical coherence tomography.” Journal of Neuroscience Methods 70.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1997). “Forward-imaging instruments for optical coherence tomography.” Optics Letters 22.Applicant
- Boppart, S. A., B. E. Bouma, et al. (1998). “Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography.” Radiology 208: 81-86.Applicant
- Boppart, S. A., J. Herrmann, et al. (1999). “High-resolution optical coherence tomography-guided laser ablation of surgical tissue.” Journal of Surgical Research 82(2): 275-84.Applicant
- Bouma, B. E. and J. G. Fujimoto (1996). “Compact Kerr-lens mode-locked resonators.” Optics Letters 21. 134-136.Applicant
- Bouma, B. E., L. E. Nelson, et al. (1998). “Optical coherence tomographic imaging of human tissue at 1.55 mu m and 1.81 mu m using Er and Tm-doped fiber sources.” Journal of Biomedical Optics 3. 76-79.Applicant
- Bouma, B. E., M. Ramaswamy-Paye, et al. (1997). “Compact resonator designs for mode-locked solid-state lasers.” Applied Physics B (Lasers and Optics) B65. 213-220.Applicant
- Bouma, B. E. and G. J. Tearney (2002). “Clinical imaging with optical coherence tomography.” Academic Radiology 9(8): 942-953.Applicant
- Bouma, B. E., G. J. Tearney, et al. (1996). “Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography.” Optics Letters 21(22): 1839.Applicant
- Bouma, B. E., G. J. Tearney, et al. (2000). “High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography.” Gastrointestinal Endoscopy 51(4): 467-474.Applicant
- Bouma, B. E., G. J. Tearney, et al. (2003). “Evaluation of intracoronary stenting by intravascular optical coherence tomography.” Heart 89(3): 317-320.Applicant
- Bourquin, S., V. Monterosso, et al. (2000). “Video-rate optical low-coherence reflectometry based on a linear smart detector array.” Optics Letters 25(2): 102-404.Applicant
- Bourquin, S., P. Seitz, et al. (2001). “Optical coherence topography based on a two-dimensional smart detector array.” Optics Letters 26(8): 512-514.Applicant
- Bouzid, A., M. A. G. Abushagur, et al. (1995). “Fiber-optic four-detector polarimeter.” Optics Communications 118(3-4): 329-334.Applicant
- Bowd, C., R. N. Weinreb, et al. (2000). “The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography.” Archives of Ophthalmology 118(1): 22-6.Applicant
- Bowd, C., L. M. Zangwill, et al. (2001). “Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function.” Investigative Ophthalmology & Visual Science 42(9): 1993-2003.Applicant
- Bowd, C., L. M. Zangwill, et al. (2002). “Imaging of the optic disc and retinal nerve fiber layer: the error of age, optic disc area, refractive error, and gender.” Journal of the Optical Society of America, A, Optics, Image Science, & Vision 19(1): 197-207.Applicant
- Brand, S., J. M. Poneros, et al. (2000). “Optical coherence tomography in the gastrointestinal tract.” Endoscopy 32(10): 796-803.Applicant
- Brezinski, M. E. and J. G. Fujimoto (1999). “Optical coherence tomography: high-resolution imaging in nontransparent tissue.” IEEE Journal of Selected Topics in Quantum Electronics 5(4): 1185-1192.Applicant
- Brezinski, M. E., G. J. Tearney, et al. (1996). “Imaging of coronary artery microstructure (in vitro) with optical coherence tomography.” American Journal of Cardiology 77 (1): 92-93.Applicant
- Brezinski, M. E., G. J. Tearney, et al. “Optical coherence tomography for optical biopsy—Properties and demonstration of vascular pathology.” Circulation 93(6): 1206-1213.Applicant
- Brezinski, M. E., G. J. Tearney, et al. (1997). “Assessing atherosclerotic plaque morphology: Comparison of optical coherence tomography and high frequency intravascular ultrasound.” Heart 77(5): 397-403.Applicant
- Brink, H. B. K. and G. J. Vanblokland (1988). “Birefringence of the Human Foveal Area Assessed Invivo with Mueller-Matrix Ellipsometry.” Journal of the Optical Society of America a—Optics Image Science and Vision 5(1): 49-57.Applicant
- Brosseau, C. and D. Bicout (1994). “Entropy Production in Multiple-Scattering of Light by a Spatially Random Medium.” Physical Review E 50(6): 4997-5005.Applicant
- Burgoyne, C. F., D. E. Mercante, et al. (2002). “Change detection in regional and volumetric disc parameters using longitudinal confocal scanning laser tomography.” Ophthalmology 109(3): 455-66.Applicant
- Candido, R. and T. J. Allen (2002). “Haemodynamics in microvascular complications in type 1 diabetes.” Diabetes—Metabolism Research and Reviews 18(4): 286-304.Applicant
- Cense, B., T. C. Chen, et al. (2004). “Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography.” Investigative Ophthalmology & Visual Science 45(8): 2606-2612.Applicant
- Cense, B., N. Nassif, et al. (2004). “Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography.” Optics Express 12(11): 2435-2447.Applicant
- Chance, B., J. S. Leigh, et al. (1988). “Comparison of Time-Resolved and Time-Unresolved Measurements of Deoxyhemoglobin in Brain.” Proceedings of the National Academy of Sciences of the United States of America 85(14): 4971-4975.Applicant
- Chang, E. P., D. A. Keedy, et al. (1974). “Ultrastructures of Rabbit Corneal Stroma—Mapping of Optical and Morphological Anisotropies.” Biochimica Et Biophysica Acta 343(3): 615-626.Applicant
- Chartier, T., A. Hideur, et al. (2001). “Measurement of the elliptical birefringence of single-mode optical fibers.” Applied Optics 40(30): 5343-5353.Applicant
- Chauhan, B. C., J. W. Blanchard, et al. (2000). “Technique for Detecting Serial Topographic Changes in the Optic Disc and Peripapillary Retina Using Scanning Laser Tomograph.” Invest Ophthalmol Vis Sci 41:775-782.Applicant
- Chen, Z. P., T. E. Milner, et al. (1997). “Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media.” Optics Letters 22(1): 64-66.Applicant
- Chen, Z. P., T. E. Milner, et al. (1997). “Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography.” Optics Letters 22(14):1119-1121.Applicant
- Chen, Z. P., Y. H. Zhao, et al. (1999). “Optical Doppler tomography.” Ieee Journal of Selected Topics in Quantum Electronics 5(4): 1134-1142.Applicant
- Cheong, W. F., S. A. Prahl, et al. (1990). “A Review of the Optical-Properties of Biological Tissues.” Ieee Journal of Quantum Electronics 26(12): 2166-2185.Applicant
- Chernikov, S. V., Y. Zhu, et al. (1997). “Supercontinuum self-Q-switched ytterbium fiber laser.” Optics Letters 22(5): 298-300.Applicant
- Cho, S. H., B. E. Bouma, et al. (1999). “Low-repetition-rate high-peak-power Kerr-lens mode-locked Ti:AI/sub 2/0/sub 3/ laser with a multiple-pass cavity.” Optics Letters 24(6): 417-419.Applicant
- Choma, M. A., M. V. Sarunic, et al. (2003). “Sensitivity advantage of swept source and Fourier domain otpical coherence tomography.” Optics Express 11(18): 2183-2189.Applicant
- Choma, M. A., C. H. Yang, et al. (2003). “Instantaneous quadrature low-coherence interferometry with 3×3 fiber-optic couplers.” Optics Letters 28(22): 2162-2164.Applicant
- Choplin, N. T. and D. C. Lundy (2001). “The sensitivity and specificity of scanning laser polarimetry in the detection of glaucoma in a clinical setting.” Ophthalmology 108 (5): 899-904.Applicant
- Christens Barry, W. A., W. J. Green, et al. (1996). “Spatial mapping of polarized light transmission in the central rabbit cornea.” Experimental Eye Research 62(6): 651-662.Applicant
- Chvapil, M., D. P. Speer, et al. (1984). “Identification of the depth of burn injury by collagen stainability.” Plastic & Reconstructive Surgery 73(3): 438-41.Applicant
- Cioffi, G. A. (2001). “Three common assumptions about ocular blood flow and glaucoma.” Survey of Ophthalmology 45: S325-S331.Applicant
- Coleman, A. L. (1999). “Glaucoma.” Lancet 354(9192): 1803-10.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (1998). “Comparison of Glaucomatous Progression Between Untreated Patients With Normal Tension Glaucoma and Patients with Therapeutically Reduced Intraocular Pressures.” Am J Ophthalmol 126: 487-97.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (1998). “The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma.” Am J Ophthalmol 126: 498-505.Applicant
- Collaborative Normal-Tension Glaucoma Study Group (2001). “Natural History of Normal-Tension Glaucoma.” Ophthalmology 108: 247-253.Applicant
- Colston, B. W., M. J. Everett, et al. (1998). “Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography.” Applied Optics 37(16): 3582-3585.Applicant
- Colston, B. W., U. S. Sathyam, et al. (1998). “Dental OCT.” Optics Express 3(6): 230-238.Applicant
- Congdon, N. G., D. S. Friedman, et al. (2003). “Important causes of visual impairment in the world today.” Jama—Journal of the American Medical Association 290(15): 2057-2060.Applicant
- Cregan, R. F., B. J. Mangan, et al. (1999). “Single-mode photonic band gap guidance of light in air.” Science 285(5433): 1537-1539.Applicant
- DalMolin, M., A. Galtarossa, et al. (1997). “Experimental investigation of linear polarization in high-birefringence single-mode fibers.” Applied Optics 36(12): 2526-2528.Applicant
- Danielson, B. L. and C. D. Whittenberg (1987). “Guided-Wave Reflectometry with Micrometer Resolution.” Applied Optics 26(14): 2836-2842.Applicant
- Dave, D. P. and T. E. Milner (2000). “Doppler-angle measurement in highly scattering media.” Optics Letters 25(20): 1523-1525.Applicant
- de Boer, J. F., T. E. Milner, et al. (1998). Two dimensional birefringence imaging in biological tissue using phase and polarization sensitive optical coherence tomography. Trends in Optics and Photonics (TOPS): Advances in Optical Imaging and Photon Migration, Orlando, USA, Optical Society of America, Washington, DC 1998.Applicant
- de Boer, J. F., C. E. Saxer, et al. (2001). “Stable carrier generation and phase-resolved digital data processing in optical coherence tomography.” Applied Optics 40(31): 5787-5790.Applicant
- Degroot, P. and L. Deck (1993). “3-Dimensional Imaging by Sub-Nyquist Sampling of White-Light Interferograms.” Optics Letters 18(17): 1462-1464.Applicant
- Denk, W., J. H. Strickler, et al. (1990). “2-Photon Laser Scanning Fluorescence Microscopy.” Science 248(4951): 73-76.Applicant
- Descour, M. R., A. H. O. Karkkainen, et al. (2002). “Toward the development of miniaturized Imaging systems for detection of pre-cancer.” Ieee Journal of Quantum Electronics 38(2): 122-130.Applicant
- Dettwiller, L. (1997). “Polarization state interference: A general investigation.” Pure and Applied Optics 6(1): 41-53.Applicant
- DiCarlo, C. D., W. P. Roach, et al. (1999). “Comparison of optical coherence tomography imaging of cataracts with histopathology.” Journal of Biomedical Optics 4.Applicant
- Ding, Z., Y. Zhao, et al. (2002). “Real-time phase-resolved optical coherence tomography and optical Doppler tomography.” Optics Express 10(5): 236-245.Applicant
- Dobrin, P. B. (1996). “Effect of histologic preparation on the cross-sectional area of arterial rings.” Journal of Surgical Research 61(2): 413-5.Applicant
- Donohue, D. J., B. J. Stoyanov, et al. (1995). “Numerical Modeling of the Corneas Lamellar Structure and Birefringence Properties.” Journal of the Optical Society of America a—Optics Image Science and Vision 12(7): 1425-1438.Applicant
- Doornbos, R. M. P., R. Lang, et al. (1999). “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy.” Physics in Medicine and Biology 44(4): 967-981.Applicant
- Drexler, W., A. Baumgartner, et al. (1997). “Biometric investigation of changes in the anterior eye segment during accommodation.” Vision Research 37(19): 2789-2800.Applicant
- Drexler, W., A. Baumgartner, et al. (1997). “Submicrometer precision biometry of the anterior segment of the human eye.” Investigative Ophthalmology & Visual Science 38(7): 1304-1313.Applicant
- Drexler, W., A. Baumgartner, et al. (1998). “Dual beam optical coherence tomography: signal identification for ophthalmologic diagnosis.” Journal of Biomedical Optics 3 (1): 55-65.Applicant
- Drexler, W., O. Findl, et al. (1998). “Partial coherence interferometry: A novel approach to biometry in cataract surgery.” American Journal of Ophthalmology 126(4): 524-534.Applicant
- Drexler, W., O. Findl, et al. (1997). “Clinical feasibility of dual beam optical coherence topography and tomography for ophthalmologic diagnosis.” Investigative Ophthalmology & Visual Science 38(4): 1038-1038.Applicant
- Drexler, W., C. K. Hitzenberger, et al. (1998). “Investigation of dispersion effects in ocular media by multiple wavelength partial coherence interferometry.” Experimental Eye Research 66(1): 25-33.Applicant
- Drexler, W., C. K. Hitzenberger, et al. (1996). “(Sub)micrometer precision biometry of the human eye by optical coherence tomography and topography.” Investigative Ophthalmology & Visual Science 37(3): 4374-4374.Applicant
- Drexler, W., C. K. Hitzenberger, et aI. (1995). “Measurement of the Thickness of Fundus Layers by Partial Coherence Tomography.” Optical Engineering 34(3): 701-710.Applicant
- Drexler, W., U. Morgner, et al. (2001). “Ultrahigh-resolution ophthalmic optical coherence tomography.” Nature Medicine 7(4): 502-507.Applicant
- Drexler, W., U. Morgner, et al. (2001). “Ultrahigh-resolution ophthalmic optical coherence tomography. [erratum appears in Nat Med May 2001;7(5):636.].” Nature Medicine 7(4): 502-7.Applicant
- Drexler, W., H. Sattmann, et al. (2003). “Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography.” Archives of Ophthalmology 121(5): 695-706.Applicant
- Drexler, W., D. Stamper, et al. (2001). “Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis.” Journal of Rheumatology 28(6): 1311-8.Applicant
- Droog, E. J., W. Steenbergen, et al. (2001). “Measurement of depth of burns by laser Doppler perfusion imaging.” Burns 27(6): 561-8.Applicant
- Dubois, A., K. Grieve, et al. (2004). “Ultrahigh-resolution full-field optical coherence tomography.” Applied Optics 43(14): 2874-2883.Applicant
- Dubois, A., L. Vabre, et al. (2002). “High-resolution full-field optical coherence tomography with a Linnik microscope.” Applied Optics 41(4): 805-812.Applicant
- Ducros, M., M. Laubscher, et al. (2002). “Parallel optical coherence tomography in scattering samples using a two-dimensional smart-pixel detector array.” Optics Communications 202(1-3): 29-35.Applicant
- Ducros, M. G., J. D. Marsack, et al. (2001). “Primate retina imaging with polarization-sensitive optical coherence tomography.” Journal of the Optical Society of America a—Optics Image Science and Vision 18(12): 2945-2956.Applicant
- Duncan, A., J. H. Meek, et al. (1995). “Optical Pathlength Measurements on Adult Head, Calf and Forearm and the Head of the Newborn-Infant Using Phase-Resolved Optical Spectroscopy.” Physics in Medicine and Biology 40(2): 295-304.Applicant
- Eigensee, A., G. Haeusler, et al. (1996). “New method of short-coherence interferometry in human skin (in vivo) and in solid volume scatterers.” Proceedings of SPIE—The International Society for Optical Engineerinq 2925: 169-178.Applicant
- Eisenbeiss, W., J. Marotz, et al. (1999). “Reflection-optical multispectral imaging method for objective determination of burn depth.” Burns 25(8): 697-704.Applicant
- Elbaum, M., M. King, et al. (1972). “Wavelength-Diversity Technique for Reduction of Speckle Size.” Journal of the Optical Society of America 62(5): 732-&.Applicant
- Ervin, J. C., H. G. Lemij, et al. (2002). “Clinician change detection viewing longitudinal stereophotographs compared to confocal scanning laser tomography in the LSU Experimental Glaucoma (LEG) Study.” Ophthalmology 109(3): 467-81.Applicant
- Essenpreis, M., C. E. Elwell, et al. (1993). “Spectral Dependence of Temporal Point Spread Functions in Human Tissues.” Applied Optics 32(4): 418-425.Applicant
- Eun, H. C. (1995). “Evaluation of skin blood flow by laser Doppler flowmetry. [Review] [151 refs].” Clinics in Dermatology 13(4): 337-47.Applicant
- Evans, J. A., J. M. Poneros, et al. (2004). “Application of a histopathologic scoring system to optical coherence tomography (OCT) images to identify high-grade dysplasia in Barrett's esophagus.” Gastroenterology 126(4): A51-A51.Applicant
- Feldchtein, F. I., G. V. Gelikonov, et al. (1998). “In vivo OCT imaging of hard and soft tissue of the oral cavity.” Optics Express 3(6): 239-250.Applicant
- Feldchtein, F. I., G. V. Gelikonov, et al. (1998). “Endoscopic applications of optical coherence tomography.” Optics Express 3(6): 257-270.Applicant
- Fercher, A. F., W. Drexler, et al. (1997). “Optical ocular tomography.” Neuro-Ophthalmology 18(2): 39-49.Applicant
- Fercher, A. F., W. Drexler, et al. (1994). Measurement of optical distances by optical spectrum modulation. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., W. Drexler, et al. (2003). “Optical coherence tomography—principles and applications.” Reports on Progress in Physics 66(2): 239-303.Applicant
- Fercher, A. F., C. Hitzenberger, et al. (1991). “Measurement of Intraocular Optical Distances Using Partially Coherent Laser-Light.” Journal of Modern Optics 38(7): 1327-1333.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1996). Ocular partial coherence interferometry. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1993). “In-Vivo Optical Coherence Tomography.” American Journal of Ophthalmology 116(1): 113-115.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1994). In-vivo dual-beam optical coherence tomography. Proceedings of SPIE—The International Society for Optical Engineering.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (1995). “Measurement of Intraocular Distances by Backscattering Spectral Interferometry.” Optics Communications 117(1-2): 43-48.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2000). “A thermal light source technique for optical coherence tomography.” Optics Communications 185(1-3): 57-64.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2001). “Numerical dispersion compensation for Partial Coherence Interferometry and Optical Coherence Tomography.” Optics Express 9(12): 610-615.Applicant
- Fercher, A. F., C. K. Hitzenberger, et al. (2002). “Dispersion compensation for optical coherence tomography depth-scan signals by a numerical technique.” Optics Communications 204(1-6): 67-74.Applicant
- Fercher, A. F., H. C. Li, et al. (1993). “Slit Lamp Laser-Doppler Interferometer.” Lasers in Surgery and Medicine 13(4): 447-452.Applicant
- Fercher, A. F., K. Mengedoht, et at. (1988). “Eye-Length Measurement by Interferometry with Partially Coherent-Light.” Optics Letters 13(3): 186-188.Applicant
- Ferro, P., M. Haelterman, et al. (1991). “All-Optical Polarization Switch with Long Low-Birefringence Fiber.” Electronics Letters 27(16): 1407-1408.Applicant
- Fetterman, M. R., D. Goswami, et al. (1998). “Ultrafast pulse shaping: amplification and characterization.” Optics Express 3(10): 366-375.Applicant
- Findl, O., W. Drexler, et al. (2001). “Improved prediction of intraocular lens power using partial coherence interferometry.” Journal of Cataract and Refractive Surgery 27 (6): 861-867.Applicant
- Fork, R. L., C. H. B. Cruz, et al. (1987). “Compression of Optical Pulses to 6 Femtoseconds by Using Cubic Phase Compensation.” Optics Letters 12(7): 483-485.Applicant
- Foschini, G. J. and C. D. Poole (1991). “Statistical-Theory of Polarization Dispersion in Single-Mode Fibers.” Journal of Lightwave Technology 9(11): 1439-1456.Applicant
- Francia, C., F. Bruyere, et al. (1998). “PMD second-order effects on pulse propagation in single-mode optical fibers.” Ieee Photonics Technology Letters 10(12): 1739-1741.Applicant
- Fried, D., R. E. Glena, et al. (1995). “Nature of Light-Scattering in Dental Enamel and Dentin at Visible and near-Infrared Wavelengths.” Applied Optics 34(7): 1278-1285.Applicant
- Fujimoto, J. G., M. E. Brezinski, et al. (1995). “Optical Biopsy and Imaging Using Optical Coherence Tomography.” Nature Medicine 1(9): 970-972.Applicant
- Fukasawa, A. and H. lijima (2002). “Optical coherence tomography of choroidal osteoma.” American Journal of Ophthalmology 133(3): 419-21.Applicant
- Fymat, A. L. (1981). “High-Resolution Interferometric Spectrophotopolarimetry.” Optical Engineering 20(1): 25-30.Applicant
- Galtarossa, A., L. Palmieri, et al. (2000). “Statistical characterization of fiber random birefringence.” Optics Letters 25(18): 1322-1324.Applicant
- Galtarossa, A., L. Palmieri, et al. (2000). “Measurements of beat length and perturbation length in long single-mode fibers.” Optics Letters 25(6): 384-386.Applicant
- Gandjbakhche, A. H., P. Mills, et al. (1994). “Light-Scattering Technique for the Study of Orientation and Deformation of Red-Blood-Cells in a Concentrated Suspension.” Applied Optics 33(6): 1070-1078.Applicant
- Garcia, N. and M. Nieto-Vesperinas (2002). “Left-handed materials do not make a perfect lens.” Physical Review Letters 88(20).Applicant
- Gelikonov, V. M., G. V. Gelikonov, et al. (1995). “Coherence Optical Tomography of Microscopic Inhomogeneities in Biological Tissues.” Jetp Letters 61(2): 158-162.Applicant
- George, N. and A. Jain (1973). “Speckle Reduction Using Multiple Tones of Illumination.” Applied Optics 12(6): 1202-1212.Applicant
- Gibson, G. N., R. Klank, et al. (1996). “Electro-optically cavity-dumped ultrashort-pulse Ti:sapphire oscillator.” Optics Letters 21(14): 1055.Applicant
- Gil, J. J. (2000). “Characteristic properties of Mueller matrices.” Journal of the Optical Society of America a—Optics Image Science and Vision 17(2): 328-334.Applicant
- Gil, J. J. and E. Bernabeu (1987). “Obtainment of the Polarizing and Retardation Parameters of a Nondepolarizing Optical-System from the Polar Decomposition of Its Mueller Matrix.” Optik 76(2): 67-71.Applicant
- Gladkova, N. D., G. A. Petrova, et al. (2000). “In vivo optical coherence tomography imaging of human skin: norm and pathology.” Skin Research and Technology 6 (1): 6-16.Applicant
- Glaessl, A., A. G. Schreyer, et al. (2001). “Laser surgical planning with magnetic resonance imaging-based 3-dimensional reconstructions for intralesional Nd : YAG laser therapy of a venous malformation of the neck.” Archives of Dermatology 137(10): 1331-1335.Applicant
- Gloesmann, M., B. Hermann, et al. (2003). “Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography.” Investigative Ophthalmoloqy & Visual Science 44(4): 1696-1703.Applicant
- Goldberg, L. and D. Mehuys (1994). “High-Power Superluminescent Diode Source.” Electronics Letters 30(20): 1682-1684.Applicant
- Goldsmith, J. A., Y. Li, et al. (2005). “Anterior chamber width measurement by high speed optical coherence tomography.” Ophthalmology 112(2): 238-244.Applicant
- Goldstein, L. E., J. A. Muffat, et al. (2003). “Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.” Lancet 361(9365): 1258-1265.Applicant
- Golubovic, B., B. E. Bouma, et al. (1996). “Thin crystal, room-temperature Cr/sup 4 +/:forstefite laser using near-infrared pumping.” Optics Letters 21(24): 1993-1995.Applicant
- Gonzalez, S. and Z. Tannous (2002). “Real-time, in vivo confocal reflectance microscopy of basal cell carcinoma.” Journal of the American Academy of Dermatology 47(6): 869-874.Applicant
- Gordon, M. O. and M. A. Kass (1999). “The Ocular Hypertension Treatment Study: design and baseline description of the participants.” Archives of Ophthalmology 117(5): 573-83.Applicant
- Grayson, T. P., J. R. Torgerson, et al. (1994). “Observation of a Nonlocal Pancharatnam Phase-Shift in the Process of Induced Coherence without Induced Emission.” Physical Review A 49(1): 626-628.Applicant
- Greaney, M. J., D. C. Hoffman, et al. (2002). “Comparison of optic nerve imaging methods to distinguish normal eyes from those with glaucoma.” Investigative Ophthalmology & Visual Science 43(1): 140-5.Applicant
- Greenfield, D. S., H. Bagga, et al. (2003). “Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography.” Archives of Ophthalmology 121(1): 41-46.Applicant
- Greenfield, D. S., R. W. Knighton, et al. (2000). “Effect of corneal polarization axis on assessment of retinal nerve fiber layer thickness by scanning laser polarimetry.” American Journal of Ophthalmology 129(6): 715-722.Applicant
- Griffin, R. A., D. D. Sampson, et al. (1995). “Coherence Coding for Photonic Code-Division Multiple-Access Networks.” Journal of Lightwave Technology 13(9): 1826-1837.Applicant
- Guedes, V., J. S. Schuman, et al. (2003). “Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes.” Ophthalmology 110(1): 177-189.Applicant
- Gueugniaud, P. Y., H. Carsin, et al. (2000). “Current advances in the initial management of major thermal burns. [Review] [76 refs].” Intensive Care Medicine 26(7): 848-56.Applicant
- Guido, S. and R. T. Tranquillo (1993). “A Methodology for the Systematic and Quantitative Study of Cell Contact Guidance in Oriented Collagen Gels—Correlation of Fibroblast Orientation and Gel Birefringence.” Journal of Cell Science 105: 317-331.Applicant
- Gurses-Ozden, R., H. Ishikawa, et al. (1999). “Increasing sampling density improves reproducibility of optical coherence tomography measurements.” Journal of Glaucoma 8(4): 238-41.Applicant
- Guzzi, R. (1998). “Scattering Theory from Homogeneous and Coated Spheres.” 1-11.Applicant
- Haberland, U. B., Vladimir; Schmitt, Hans J. (1996). “Optical coherent tomography of scattering media using electrically tunable near-infrared semiconductor laser.” Applied Optics Draft Copy.Applicant
- Haberland, U. R., Walter; Blazek, Vladimir; Schmitt, Hans J. (1995). “Investigation of highly scattering media using near-infrared continuous wave tunable semiconductor laser.” Proc. SPIE , 2389: 503-512.Applicant
- Hale, G. M. and M. R. Querry (1973). “Optical-Constants of Water in 200-Nm to 200-Mum Wavelength Region.” Applied Optics 12(3): 555-563.Applicant
- Hammer, D. X., R. D. Ferguson, et al. (2002). “Image stabilization for scanning laser ophthalmoscopy.” Optics Express 10(26): 1542.Applicant
- Hara, T., Y. Ooi, et al. (1989). “Transfer Characteristics of the Microchannel Spatial Light-Modulator.” Applied Optics 28(22): 4781-4786.Applicant
- Harland, C. C., S. G. Kale, et al. (2000). “Differentiation of common benign pigmented skin lesions from melanoma by high-resolution ultrasound.” British Journal of Dermatology 143(2): 281-289.Applicant
- Hartl, I., X. D. Li, et al. (2001). “Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber.” Optics Letters 26(9): 608-610.Applicant
- Hassenstein, A., A. A. Bialasiewicz, et al. (2000). “Optical coherence tomography in uveitis patients.” American Journal of Ophthalmoloqv 130(5): 669-70.Applicant
- Hattenhauer, M. G., D. H. Johnson, et al. (1998). “The probability of blindness from open-angle glaucoma. [see comments].” Ophthalmology 105(11): 2099-104.Applicant
- Hausler, G., J. M. Herrmann, et al. (1996). “Observation of light propagation in volume scatterers with 10(11)-fold slow motion.” Optics Letters 21(14): 1087-1089.Applicant
- Hazebroek, H. F. and A. A. Holscher (1973). “Interferometric Ellipsometry.” Journal of Physics E—Scientific Instruments 6(9): 822-826.Applicant
- Hazebroek, H. F. and W. M. Visser (1983). “Automated Laser Interferometric Ellipsometry and Precision Reflectometry.” Journal of Physics E—Scientific Instruments 16(7): 654-661.Applicant
- He, Z. Y., N. Mukohzaka, et al. (1997). “Selective image extraction by synthesis of the coherence function using two-dimensional optical lock-in amplifier with microchannel spatial light modulator.” Ieee Photonics Technology Letters 9(4): 514-516.Applicant
- Hee, M. R., J. A. Izatt, et al. (1993). “Femtosecond Transillumination Optical Coherence Tomography.” Optics Letters 18(12): 950-952.Applicant
- Hee, M. R., J. A. Izatt, et al. (1995). “Optical coherence tomography of the human retina.” Archives of Ophthalmology 113(3): 325-32.Applicant
- Hee, M. R., C. A. Puliafito, et al. (1998). “Topography of diabetic macular edema with optical coherence tomography.” Ophthalmology 105(2): 360-70.Applicant
- Hee, M. R., C. A. Puliafito, et al. (1995). “Quantitative assessment of macular edema with optical coherence tomography.” Archives of Ophthalmoloqy 113(8): 1019-29.Applicant
- Hellmuth, T. and M. Welle (1998). “Simultaneous measurement of dispersion, spectrum, and distance with a fourier transform spectrometer.” Journal of Biomedical Optics 3(1): 7-11.Applicant
- Hemenger, R. P. (1989). “Birefringence of a medium of tenuous parallel cylinders.” Applied Optics 28(18): 4030-4034.Applicant
- Henry, M. (1981). “Fresnel-Arago Laws for Interference in Polarized Light—Demonstration Experiment.” American Journal of Physics 49(7): 690-691.Applicant
- Herz, P. R., Y. Chen, et al. (2004). “Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography.” Optics Letters 29(19): 2261-2263.Applicant
- Hirakawa, H., H. Iijima, et al. (1999). “Optical coherence tomography of cystoid macular edema associated with retinitis pigmentosa.” American Journal of Ophthalmology 128(2): 185-91.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1994). “Interferometric Measurement of Corneal Thickness with Micrometer Precision.” American Journal of Ophthalmology 118(4): 468-476.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1999). “Dispersion effects in partial coherence interferometry: Implications for intraocular ranging.” Journal of Biomedical Optics 4(1): 144-151.Applicant
- Hitzenberger, C. K., A. Baumgartner, et al. (1998). “Dispersion induced multiple signal peak splitting in partial coherence interferometry.” Optics Communications 154 (4): 179-185.Applicant
- Hitzenberger, C. K., M. Danner, et al. (1999). “Measurement of the spatial coherence of superluminescent diodes.” Journal of Modern Optics 46(12): 1763-1774.Applicant
- Hitzenberger, C. K. and A. F. Fercher (1999). “Differential phase contrast in optical coherence tomography.” Optics Letters 24(9): 622-624.Applicant
- Hitzenberger, C. K., M. Sticker, et al. (2001). “Differential phase measurements in low-coherence interferometry without 2 pi ambiguity.” Optics Letters 26(23): 1864-1866.Applicant
- Hoeling, B. M., A. D. Fernandez, et al. (2000). “An optical coherence microscope for 3-dimensional imaging in developmental biology.” Optics Express 6(7): 136-146.Applicant
- Hoerauf, H., C. Scholz, et al. (2002). “Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye.” Archives of Ophthalmology 120(6): 816-9.Applicant
- Hoffmann, K., M. Happe, et al. (1998). “Optical coherence tomography (OCT) in dermatology.” Journal of Investigative Dermatology 110(4): 583-583.Applicant
- Hoh, S. T., D. S. Greenfield, et al. (2000). “Optical coherence tomography and scanning laser polarimetry in normal, ocular hypertensive, and glaucomatous eyes.” American Journal of Ophthalmology 129(2): 129-35.Applicant
- Hohenleutner, U., M. Hilbert, et al. (1995). “Epidermal Damage and Limited Coagulation Depth with the Flashlamp-Pumped Pulsed Dye-Laser—a Histochemical-Study.” Journal of Investigative Dermatology 104(5): 798-802.Applicant
- Holland, A. J. A., H. C. O. Martin, et al. (2002). “Laser Doppler imaging prediction of burn wound outcome in children.” Burns 28(1): 11-17.Applicant
- Hotate, K. and T. Okugawa (1994). “Optical Information-Processing by Synthesis of the Coherence Function.” Journal of Lightwave Technology 12(7): 1247-1255.Applicant
- Hourdakis, C. J. and A. Perris (1995). “A Monte-Carlo Estimation of Tissue Optical-Properties for Use in Laser Dosimetry.” Physics in Medicine and Biology 40(3): 351-364.Applicant
- Hu, Z., F. Li, et al. (2000). “Wavelength-tunable narrow-linewidth semiconductor fiber-ring laser.” IEEE Photonics Technology Letters 12(8): 977-979.Applicant
- Huang, F., W. Yang, et al. (2001). “Quadrature spectral interferometric detection and pulse shaping.” Optics Letters 26(6): 382-384.Applicant
- Huang, X. R. and R. W. Knighton (2002). “Linear birefringence of the retinal nerve fiber layer measured in vitro with a multispectral imaging micropolarimeter.” Journal of Biomedical Optics 7(2): 199-204.Applicant
- Huber, R., M. Wojtkowski, et al. (2005). “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles.” Optics Express 13(9): 3513-3528.Applicant
- Hunter, D. G., J. C. Sandruck, et al. (1999). “Mathematical modeling of retinal birefringence scanning.” Journal of the Optical Society of America a—Optics Image Science and Vision 16(9): 2103-2111.Applicant
- Hurwitz, H. H. and R. C. Jones (1941). “A new calculus for the treatment of optical systems II. Proof of three general equivalence theorems.” Journal of the Optical Society of America 31(7): 493-499.Applicant
- Huttner, B., C. De Barros, et al. (1999). “Polarization-induced pulse spreading in birefringent optical fibers with zero differential group delay.” Optics Letters 24(6): 370-372.Applicant
- Huttner, B., B. Gisin, et al. (1999). “Distributed PMD measurement with a polarization-OTDR in optical fibers.” Journal of Lightwave Technology 17(10): 1843-1848.Applicant
- Huttner, B., J. Reecht, et al. (1998). “Local birefringence measurements in single-mode fibers with coherent optical frequency-domain reflectometry.” Ieee Photonics Technology Letters 10(10): 1458-1460.Applicant
- Hyde, S. C. W., N. P. Barry, et al. (1995). “Sub-100-Mu-M Depth-Resolved Holographic Imaging through Scattering Media in the near-Infrared.” Optics Letters 20(22): 2330-2332.Applicant
- Hyde, S. C. W., N. P. Barry, et al. (1995). “Depth-Resolved Holographic Imaging through Scattering Media by Photorefraction.” Optics Letters 20(11): 1331-1333.Applicant
- Iftimia, N. V., B. E. Bouma, et al. (2004). “Adaptive ranging for optical coherence tomography.” Optics Express 12(17): 4025-4034.Applicant
- Iida, T., N. Hagimura, et al. (2000). “Evaluation of central serous chorioretinopathy with optical coherence tomography.” American Journal of Ophthalmology 129(1): 16-20.Applicant
- Imai, M., H. Iijima, et al. (2001). “Optical coherence tomography of tractional macular elevations in eyes with proliferative diabetic retinopathy. [republished in Am J Ophthalmol. Sep. 2001;132(3):458-61 ; 11530091.].” American Journal of Ophthalmology 132(1): 81-4.Applicant
- Indebetouw, G. and P. Klysubun (2000). “Imaging through scattering media with depth resolution by use of low-coherence gating in spatiotemporal digital holography.” Optics Letters 25(4): 212-214.Applicant
- Ip, M. S., B. J. Baker, et al. (2002). “Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography.” Archives of Ophthalmology 120(1): 29-35.Applicant
- Ismail, R., V. Tanner, et al. (2002). “Optical coherence tomography imaging of severe commotio retinae and associated macular hole.” British Journal of Ophthalmology 86(4): 473-4.Applicant
- Izatt, J. A., M. R. Hee, et al. (1994). “Optical Coherence Microscopy in Scattering Media.” Optics Letters 19(8): 590-592.Applicant
- Izatt, J. A., M. R. Hee, et al. (1994). “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography.” Archives of Ophthalmology 112 (12): 1584-9.Applicant
- Izatt, J. A., M. D. Kulkami, et al. (1997). “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography.” Optics Letters 22(18): 1439-1441.Applicant
- Izatt, J. A., M. D. Kulkarni, et al. (1996). “Optical coherence tomography and microscopy in gastrointestinal tissues.” IEEE Journal of Selected Topics in Quantum Electronics 2(4): 1017.Applicant
- Jacques, S. L., J. S. Nelson, et al. (1993). “Pulsed Photothermal Radiometry of Port-Wine-Stain Lesions.” Applied Optics 32(13): 2439-2446.Applicant
- Jacques, S. L., J. R. Roman, et al. (2000). “Imaging superficial tissues with polarized light.” Lasers in Surgery and Medicine 26(2): 119-129.Applicant
- Jang, I. K., B. E. Bouma, et al. (2002). “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound.” Journal of the American College of Cardiology 39(4): 604-609.Applicant
- Jang, I. K., B. D. MacNeill, et al. (2002). “In-vivo characterization of coronary plaques in patients with ST elevation acute myocardial infarction using optical coherence tomography (OCT).” Circulation 106(19): 698-698 3440 Suppl. S,.Applicant
- Jang, I. K., G. J. Tearney, et al. (2000). “Comparison of optical coherence tomography and intravascular ultrasound for detection of coronary plaques with large lipid-core in living patients.” Circulation 102(18): 509-509.Applicant
- Jeng, J. C., A. Bridgeman, et al. (2003). “Laser Doppler imaging determines need for excision and grafting in advance of clinical judgment: a prospective blinded trial.” Burns 29(7): 665-670.Applicant
- Jesser, C. A., S. A. Boppart, et al. (1999). “High resolution imaging of transitional cell carcinoma with optical coherence tomography: feasibility for the evaluation of bladder pathology.” British Journal of Radiology 72: 1170-1176.Applicant
- Johnson, C. A., J. L. Keltner, et al. (2002). “Baseline visual field characteristics in the ocular hypertension treatment study.” Ophthalmoloqy 109(3): 432-7.Applicant
- Jones, R. C. (1941). “A new calculus for the treatment of optical systems III. The Sohncke theory of optical activity.” Journal of the Optical Society of America 31 (7): 500-503.Applicant
- Jones, R. C. (1941). “A new calculus for the treatment of optical systems I. Description and discussion of the calculus.” Journal of the Optical Society of America 31(7): 488-493.Applicant
- Jones, R. C. (1942). “A new calculus for the treatment of optical systems. IV.” Journal of the Optical Society of America 32(8): 486-493.Applicant
- Jones, R. C. (1947). “A New Calculus for the Treatment of Optical Systems .6. Experimental Determination of the Matrix.” Journal of the Optical Society of America 37(2): 110-112.Applicant
- Jones, R. C. (1947). “A New Calculus for the Treatment of Optical Systems .5. A More General Formulation, and Description of Another Calculus.” Journal of the Optical Society of America 37(2): 107-110.Applicant
- Jones, R. C. (1948). “A New Calculus for the Treatment of Optical Systems .7. Properties of the N-Matrices.” Journal of the Optical Society of America 38(8): 671-685.Applicant
- Jones, R. C. (1956). “New Calculus for the Treatment of Optical Systems .8. Electromagnetic Theory.” Journal of the Optical Society of America 46(2): 126-131.Applicant
- Jopson, R. MThe ., L. E. Nelson, et al. (1999). “Measurement of second-order polarization-mode dispersion vectors in optical fibers.” Ieee Photonics Technology Letters 11 (9): 1153-1155.Applicant
- Jost, B. M., A. V. Sergienko, et al. (1998). “Spatial correlations of spontaneously down-converted photon pairs detected with a single-photon-sensitive CCD camera.” Optics Express 3(2): 81-88.Applicant
- Kaplan, B., E. Compain, et al. (2000). “Phase-modulated Mueller ellipsometry characterization of scattering by latex sphere suspensions.” Applied Optics 39 (4): 629-636.Applicant
- Kass, M. A., D. K. Heuer, et al. (2002). “The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.” Archives of Ophthalmology 120(6): 701-13; discussion 829-30.Applicant
- Kasuga, Y., J. Arai, et al. (2000). “Optical coherence tomograghy to confirm early closure of macular holes.” American Journal of Ophthalmology 130(5): 675-6.Applicant
- Kaufman, T., S. N. Lusthaus, et al. (1990). “Deep Partial Skin Thickness Burns—a Reproducible Animal-Model to Study Burn Wound-Healing.” Burns 16(1): 13-16.Applicant
- Kemp, N. J., J. Park, et al. (2005). “High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography.” Journal of the Optical Society of America a—Optics Image Science and Vision 22(3): 552-560.Applicant
- Kerrigan-Baumrind, L. A., H. A. Quigley, et al. (2000). “Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons.” Investigative Ophthalmology & Visual Science 41(3): 741-8.Applicant
- Kesen, M. R., G. L. Spaeth, et al. (2002). “The Heidelberg Retina Tomograph vs clinical impression in the diagnosis of glaucoma.” American Journal of Ophthalmology 133(5): 613-6.Applicant
- Kienle, A. and R. Hibst (1995). “A New Optimal Wavelength for Treatment of Port-Wine Stains.” Physics in Medicine and Biology 40(10): 1559-1576.Applicant
- Kienle, A., L. Lilge, et al. (1996). “Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue.” Applied Optics 35(13): 2304-2314.Applicant
- Kim, B. Y. and S. S. Choi (1981). “Analysis and Measurement of Birefringence in Single-Mode Fibers Using the Backscattering Method.” Optics Letters 6(11): 578-580.Applicant
- Kimel, S., L. O. Svaasand, et al. (1994). “Differential Vascular-Response to Laser Photothermolysis.” Journal of Investigative Dermatology 103(5): 693-700.Applicant
- Kloppenberg, F. W. H., G. Beerthuizen, et al. (2001). “Perfusion of burn wounds assessed by Laser Doppler Imaging is related to burn depth and healing time.” Burns 27(4): 359-363.Applicant
- Knighton, R. W. and X. R. Huang (2002). “Analytical methods for scanning laser polarimetry.” Optics Express 10(21): 1179-1189.Applicant
- Knighton, R. W., X. R. Huang, et al. (2002). “Analytical model of scanning laser polarimetry for retinal nerve fiber layer assessment.” Investigative Ophthalmology & Visual Science 43(2): 383-392.Applicant
- Knuettel, A. R. S., Joseph M.: Shay, M.; Knutson, Jay R. (1994). “Stationary low-coherence light imaging and spectroscopy using a CCD camera.” Proc. SPIE , vol. 2135: p. 239-250.Applicant
- Knuttel, A. and M. Boehlau-Godau (2000). “Spatially confined with temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography.” Journal of Biomedical Optics 5(1): 83-92.Applicant
- Knuttel, A. and J. M. Schmitt (1993). “Stationary Depth-Profiling Reflectometer Based on Low-Coherence Interferometry.” Optics Communications 102(3-4): 193-198.Applicant
- Knuttel, A., J. M. Schmitt, et al. (1994). “Low-Coherence Reflectometry for Stationary Lateral and Depth Profiling with Acoustooptic Deflectors and a Ccd Camera.” Optics Letters 19(4): 302-304.Applicant
- Kobayashi, M., H. Hanafusa, et al. (1991). “Polarization-Independent Interferometric Optical-Time-Domain Reflectometer.” Journal of Lightwave Technology 9(5): 623-628.Applicant
- Kolios, M. C., M. D. Sherar, et al. (1995). “Large Blood-Vessel Cooling in Heated Tissues—a Numerical Study.” Physics in Medicine and Biology 40(4): 477-494.Applicant
- Koozekanani, D., K. Boyer, et al. (2001). “Retinal thickness measurements from optical coherence tomography using a Markov boundary model.” Ieee Transactions on Medical Imaging 20(9): 900-916.Applicant
- Kop, R. H. J. and R. Sprik (1995). “Phase-sensitive interferometry with ultrashort optical pulses.” Review of Scientific Instruments 66(12): 5459-5463.Applicant
- Kramer, R. Z., J. Bella, et al. (1999). “Sequence dependent conformational variations of collagen triple-helical structure.” Nature Structural Biology 6(5): 454-7.Applicant
- Kulkarni, M. D., T. G. van Leeuwen, et al. (1998). “Velocity-estimation accuracy and frame-rate limitations in color Doppler optical coherence tomography.” Optics Letters 23(13): 1057-1059.Applicant
- Kwon, Y. H., C. S. Kim, et al. (2001). “Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma.” American Journal of Ophthalmology 132(1): 47-56.Applicant
- Kwong, K. F., D. Yankelevich, et al. (1993). “400-Hz Mechanical Scanning Optical Delay-Line.” Optics Letters 18(7): 558-560.Applicant
- Landers, J., I. Goldberg, et al. (2002). “Analysis of risk factors that may be associated with progression from ocular hypertension to primary open angle glaucoma.” Clin Experiment Ophthalmogy 30(4): 242-7.Applicant
- Laszlo, A. and A. Venetianer (1998). Heat resistance in mammalian cells: Lessons and challenges. Stress of Life. 851: 169-178.Applicant
- Laszlo, A. and A. Venetianer (1998). “Heat resistance in mammalian cells: lessons and challenges. [Review] [52 refs].” Annals of the New York Academy of Sciences 851: 169-78.Applicant
- Laufer, J., R. Simpson, et al. (1998). “Effect of temperature on the optical properties of ex vivo human dermis and subdermis.” Physics in Medicine and Biology 43(9): 2479-2489.Applicant
- Lederer, D. E., J. S. Schuman, et al. (2003). “Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography.” American Journal of Ophthalmology 135(6): 838-843.Applicant
- Lee, P. P., Z. W. Feldman, et al. (2003). “Longitudinal prevalence of major eye diseases.” Archives of Ophthalmology 121(9): 1303-1310.Applicant
- Lehrer, M. S., T. T. Sun, et al. (1998). “Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation.” Journal of Cell Science 111(Pt 19): 2867-75.Applicant
- Leibowitz, H. M., D. E. Krueger, et al. (1980). “The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975.” Survey of Ophthalmology 24(Suppl): 335-610.Applicant
- Leitgeb, R., C. K. Hitzenberger, et al. (2003). “Performance of fourier domain vs. time domain optical coherence tomography.” Optics Express 11(8): 889-894.Applicant
- Leitgeb, R., L. F. Schmetterer, et al. (2002). “Flow velocity measurements by frequency domain short coherence interferometry.” Proc. SPIE 4619: 16-21.Applicant
- Leitgeb, R. A., W. Drexler, et al. (2004). “Ultrahigh resolution Fourier domain optical coherence tomography.” Optics Express 12(10): 2156-2165.Applicant
- Leitgeb, R. A., C. K. Hitzenberger, et al. (2003). “Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography.” Optics Letters 28(22): 2201-2203.Applicant
- Leitgeb, R. A., L. Schmetterer, et al. (2003). “Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography.” Optics Express 11(23): 3116-3121.Applicant
- Leitgeb, R. A., L. Schmetterer, et al. (2004). “Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography.” Optics Letters 29 (2): 171-173.Applicant
- LeRoyBrehonnet, F. and B. LeJeune (1997). “Utilization of Mueller matrix formalism to obtain optical targets depolarization and polarization properties.” Progress in Quantum Electronics 21(2): 109-151.Applicant
- Leske, M. C., A. M. Connell, et al. (1995). “Risk factors for open-angle glaucoma. The Barbados Eye Study. [see comments].” Archives of Ophthalmology 113(7): 918-24.Applicant
- Leske, M. C., A. M. Connell, et al. (2001). “Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. [see comments].” Archives of Ophthalmology 119(1): 89-95.Applicant
- Leske, M. C., A. Heijl, et al. (1999). “Early Manifest Glaucoma Trial. Design and Baseline Data.” Ophthalmology 106(11): 2144-2153.Applicant
- Lewis, S. E., J. R. DeBoer, et al. (2005). “Sensitive, selective, and analytical improvements to a porous silicon gas sensor.” Sensors and Actuators B: Chemical 110(1): 54-65.Applicant
- Lexer, F., C. K. Hitzenberger, et al. (1999). “Dynamic coherent focus OCT with depth-independent transversal resolution.” Journal of Modern Optics 46(3): 541-553.Applicant
- Li, X., C. Chudoba, et al. (2000). “Imaging needle for optical coherence tomography.” Optics Letters 25: 1520-1522.Applicant
- Li, X., T. H. Ko, et al. (2001). “Intraluminal fiber-optic Doppler imaging catheter for structural and functional optical coherence tomography.” Optics Letters 26: 1906-1908.Applicant
- Liddington, M. I. and P. G. Shakespeare (1996). “Timing of the thermographic assessment of burns.” Burns 22(1): 26-8.Applicant
- Lindmo, T., D. J. Smithies, et al. (1998). “Accuracy and noise in optical Doppler tomography studied by Monte Carlo simulation.” Physics in Medicine and Biology 43(10): 3045-3064.Applicant
- Liu, J., X. Chen, et al. (1999). “New thermal wave aspects on burn evaluation of skin subjected to instantaneous heating.” IEEE Transactions on Biomedical Engineering 46(4): 420-8.Applicant
- Luke, D. G., R. McBride, et al. (1995). “Polarization mode dispersion minimization in fiber-wound piezoelectric cylinders.” Optics Letters 20(24): 2550-2552.Applicant
- MacNeill, B. D., I. K. Jang, et al. (2004). “Focal and multi-focal plaque distributions in patients with macrophage acute and stable presentations of coronary artery disease.” Journal of the American College of Cardiology 44(5): 972-979.Applicant
- Mahgerefteh, D. and C. R. Menyuk (1999). “Effect of first-order PMD compensation on the statistics of pulse broadening in a fiber with randomly varying birefringence.” Ieee Photonics Technology Letters 11(3): 340-342.Applicant
- Maitland, D. J. and J. T. Walsh, Jr. (1997). “Quantitative measurements of linear birefringence during heating of native collagen.” Lasers in Surgery & Medicine 20 (3): 310-8.Applicant
- Majaron, B., S. M. Srinivas, et al. (2000). “Deep coagulation of dermal collagen with repetitive Er : YAG laser irradiation.” Lasers in Surgery and Medicine 26(2): 215-222.Applicant
- Mansuripur, M. (1991). “Effects of High-Numerical-Aperture Focusing on the State of Polarization in Optical and Magnetooptic Data-Storage Systems.” Applied Optics 30(22): 3154-3162.Applicant
- Marshall, G. W., S. J. Marshall, et al. (1997). “The dentin substrate: structure and properties related to bonding.” Journal of Dentistry 25(6): 441-458.Applicant
- Martin, P. (1997). “Wound healing—Aiming for perfect skin regeneration.” Science 276 (5309): 75-81.Applicant
- Martinez, O. E. (1987). “3000 Times Grating Compressor with Positive Group-Velocity Dispersion—Application to Fiber Compensation in 1.3-1.6 Mu-M Region.” Ieee Journal of Quantum Electronics 23(1): 59-64.Applicant
- Martinez, O. E., J. P. Gordon, et al. (1984). “Negative Group-Velocity Dispersion Using Refraction.” Journal of the Optical Society of America a—Optics Image Science and Vision 1(10): 1003-1006.Applicant
- McKinney, J. D., M. A. Webster, et al. (2000). “Characterization and imaging in optically scattering media by use of laser speckle and a variable-coherence source.” Optics Letters 25(1): 4-6.Applicant
- Miglior, S., M. Casula, et al. (2001). “Clinical ability of Heidelberg retinal tomograph examination to detect glaucomatous visual field changes.” Ophthalmology 108 (9): 1621-7.Applicant
- Milner, T. E., D. M. Goodman, et al. (1996). “Imaging laser heated subsurface chromophores in biological materials: Determination of lateral physical dimensions.” Physics in Medicine and Biology 41(1): 31-44.Applicant
- Milner, T. E., D. M. Goodman, et al. (1995). “Depth Profiling of Laser-Heated Chromophores in Biological Tissues by Pulsed Photothermal Radiometry.” Journal of the Optical Society of America a—Optics Image Science and Vision 12 (7): 1479-1488.Applicant
- Milner, T. E., D. J. Smithies, et al. (1996). “Depth determination of chromophores in human skin by pulsed photothermal radiometry.” Applied Optics 35(19): 3379-3385.Applicant
- Mishchenko, M. I. and J. W. Hovenier (1995). “Depolarization of Light Backscattered by Randomly Oriented Nonspherical Particles.” Optics Letters 20(12): 1356-&.Applicant
- Mistlberger, A., J. M. Liebmann, et al. (1999). “Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes.” Ophthalmology 106(10): 2027-32.Applicant
- Mitsui, T. (1999). “High-speed detection of ballistic photons propagating through suspensions using spectral interferometry.” Japanese Journal of Applied Physics Part 1—Regular Papers Short Notes & Review Papers 38(5A): 2978-2982.Applicant
- Molteno, A. C., N. J. Bosma, et al. (1999). “Otago glaucoma surgery outcome study: long-term results of trabeculectomy—1976 to 1995.” Ophthalmology 106(9): 1742-50.Applicant
- Morgner, U., W. Drexler, et al. (2000). “Spectroscopic optical coherence tomography.” Optics Letters 25(2): 111-113.Applicant
- Morgner, U., F. X. Kartner, et al. (1999). “Sub-two-cycle pulses from a Kerr-lens mode-locked Ti : sapphire laser (vol. 24, p. 411, 1999).” Optics Letters 24(13): 920-920.Applicant
- Mourant, J. R., A. H. Hielscher, et al. (1998). “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells.” Cancer Cytopathology 84(6): 366-374.Applicant
- Muller, M., J. Squier, et al. (1998). “Dispersion pre-compensation of 15 femtosecond optical pulses for high-numerical-aperture objectives.” Journal of Microscopy—Oxford 191: 141-150.Applicant
- Muscat, S., N. McKay, et al. (2002). “Repeatability and reproducibility of corneal thickness measurements by optical coherence tomography.” Investigative Ophthalmology & Visual Science 43(6): 1791-5.Applicant
- Musch, D. C., P. R. Lichter, et al. (1999). “The Collaborative Initial Glaucoma Treatment Study. Study Design, MethodsR, and Baseline Characteristics of Enrolled Patients.” Ophthalmology 106: 653-662.Applicant
- Neerken, S., Lucassen, G.W., Bisschop, M.A., Lenderink, E., Nuijs, T.A.M. (2004). “Characterization of age-related effects in human skin: A comparative study that applies confocal laser scanning microscopy and optical coherence tomography.” Journal of Biomedical Optics 9(2):274-281.Applicant
- Nelson, J. S., K. M. Kelly, et al. (2001). “Imaging blood flow in human port-wine stain in situ and in real time using optical Doppler tomography.” Archives of Dermatology 137(6): 741-744.Applicant
- Newson, T. P., F. Farahi, et al. (1988). “Combined Interferometric and Polarimetric Fiber Optic Temperature Sensor with a Short Coherence Length Source.” Optics Communications 68(3): 161-165.Applicant
- November, L. J. (1993). “Recovery of the Matrix Operators in the Similarity and Congruency Transformations—Applications in Polarimetry.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(4): 719-739.Applicant
- Oh, W. Y., S. H. Yun, et al. (2005). “Wide tuning range wavelength-swept laser with two semiconductor optical amplifiers.” Ieee Photonics Technology Letters 17(3): 678-680.Applicant
- Oka, K. and T. Kato (1999). “Spectroscopic polarimetry with a channeled spectrum.” Optics Letters 24(21): 1475-1477.Applicant
- Okugawa, T. and K. Rotate (1996). “Real-time optical image processing by synthesis of the coherence function using real-time holography.” Ieee Photonics Technology Letters 8(2): 257-259.Applicant
- Oshima, M., R. Torii, et al. (2001). “Finite element simulation of blood flow in the cerebral artery.” Computer Methods in Applied Mechanics and Engineering 191 (6-7): 661-671.Applicant
- Pan, Y. T., H. K. Xie, et al. (2001). “Endoscopic optical coherence tomography based on a microelectromechanical mirror.” Optics Letters 26(24): 1966-1968.Applicant
- Parisi, V., G. Manni, et al. (2001). “Correlation between optical coherence tomography, pattern electroretinogram, and visual evoked potentials in open-angle glaucoma patients.” Ophthalmology 108(5): 905-12.Applicant
- Park, B. H., M. C. Pierce, et al. (2005). “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 mu m.” Optics Express 13(11): 3931-3944.Applicant
- Park, D. H., J. W. Hwang, et al. (1998). “Use of laser Doppler flowmetry for estimation of the depth of burns.” Plastic and Reconstructive Surgery 101(6): 1516-1523.Applicant
- Pendry, J. B., A. J. Holden, et al. (1999). “Magnetism from conductors and enhanced nonlinear phenomena.” Ieee Transactions on Microwave Theory and Techniques 47(11):2075-2084.Applicant
- Penninckx, D. and V. Morenas (1999). “Jones matrix of polarization mode dispersion.” Optics Letters 24(13): 875-877.Applicant
- Pierce, M. C., M. Shishkov, et al. (2005). “Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography.” Optics Express 13(15): 5739-5749.Applicant
- Pircher, M., E. Gotzinger, et al. (2003). “Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography.” Optics Express 11(18): 2190-2197.Applicant
- Pircher, M., E. Gotzinger, et al. (2003). “Speckle reduction in optical coherence tomography by frequency compounding.” Journal of Biomedical Optics 8(3): 565-569.Applicant
- Podoleanu, A. G., G. M. Dobre, et al. (1998). “En-face coherence imaging using galvanometer scanner modulation.” Optics Letters 23(3): 147-149.Applicant
- Podoleanu, A. G. and D. A. Jackson (1999). “Noise analysis of a combined optical coherence tomograph and a confocal scanning ophthalmoscope.” Applied Optics 38(10): 2116-2127.Applicant
- Podoleanu, A. G., J. A. Rogers, et al. (2000). “Three dimensional OCT images from retina and skin.” Optics Express 7(9): 292-298.Applicant
- Podoleanu, A. G., M. Seeger, et al. (1998). “Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry.” Journal of Biomedical Optics 3(1): 12-20.Applicant
- Poole, C. D. (1988). “Statistical Treatment of Polarization Dispersion in Single-Mode Fiber.” Optics Letters 13(8): 687-689.Applicant
- Povazay, B., K. Bizheva, et al. (2002). “Submicrometer axial resolution optical coherence tomography.” Optics Letters 27(20): 1800-1802.Applicant
- Qi, B., A. P. Himmer, et al. (2004). “Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror.” Optics Communications 232(1-6): 123-128.Applicant
- Radhakrishnan, S., A. M. Rollins, et al. (2001). “Real-time optical coherence tomography of the anterior segment at 1310 nm.” Archives of Ophthalmology 119(8): 1179-1185.Applicant
- Rogers, A. J. (1981). “Polarization-Optical Time Domain Reflectometry—a Technique for the Measurement of Field Distribution.” Applied Optics 20(6): 1060-1074.Applicant
- Rollins, A. M. and J. A. Izatt (1999). “Optimal interferometer designs for optical coherence tomography.” Optics Letters 24(21): 1484-1486.Applicant
- Rollins, A. M., R. Ung-arunyawee, et al. (1999). “Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design.” Optics Letters 24(19): 1358-1360.Applicant
- Rollins, A. M., S. Yazdanfar, et al. (2002). “Real-time in vivo colors Doppler optical coherence tomography.” Journal of Biomedical Optics 7(1): 123-129.Applicant
- Rollins, A. M., S. Yazdanfar, et al. (2000). “Imaging of human retinal hemodynamics using color Doppler optical coherence tomography.” Investigative Ophthalmology & Visual Science 41(4): S548-S548.Applicant
- Sandoz, P. (1997). “Wavelet transform as a processing tool in white-light interferometry.” Optics Letters 22(14): 1065-1067.Applicant
- Sankaran, V., M. J. Everett, et al. (1999). “Comparison of polarized-light propagation in biological tissue and phantoms.” Optics Letters 24(15): 1044-1046.Applicant
- Sankaran, V., J. T. Walsh, et al. (2000). “Polarized light propagation through tissue phanto, ehms containing densely packed scatterers.” Optics Letters 25(4): 239-241.Applicant
- Sarunic, M. V., M. A. Choma, et al. (2005). “Instantaneous complex conjugate resolved spectral domain and swept-source OCT using 3×3 fiber couplers.” Optics Express 13(3): 957-967.Applicant
- Sathyam, U. S., B. W. Colston, et al. (1999). “Evaluation of optical coherence quantitation of analytes in turbid media by use of two wavelengths.” Applied Optics 38(10): 2097-2104.Applicant
- Schmitt, J. M. (1997). “Array detection for speckle reduction in optical coherence microscopy.” Physics in Medicine and Biology 42(7): 1427-1439.Applicant
- Schmitt, J. M. (1999). “Optical coherence tomography (OCT): A review.” Ieee Journal of Selected Topics in Quantum Electronics 5(4): 1205-1215.Applicant
- Schmitt, J. M. and A. Knuttel (1997). “Model of optical coherence tomography of heterogeneous tissue.” Journal of the Optical Society of America a—Optics Image Science and Vision 14(6): 1231-1242.Applicant
- Schmitt, J. M., S. L. Lee, et al. (1997). “An optical coherence microscope with enhanced resolving power in thick tissue.” Optics Communications 142(4-6): 203-207.Applicant
- Schmitt, J. M., S. H. Xiang, et al. (1998). “Differential absorption imaging with optical coherence tomography.” Journal of the Optical Society of America a—Optics Image Science and Vision 15(9): 2288-2296.Applicant
- Schmitt, J. M., S. H. Xiang, et aI. (1999). “Speckle in optical coherence tomography.” Journal of Biomedical Optics 4(1): 95-105.Applicant
- Schmitt, J. M., M. J. Yadlowsky, et al. (1995). “Subsurface Imaging of Living Skin with Optical Coherence Microscopy.” Dermatology 191(2): 93-98.Applicant
- Shi, H., J. Finlay, et al. (1997). “Multiwavelength 10-GHz picosecond pulse generation from a single-stripe semiconductor diode laser.” Ieee Photonics Technology Letters 9(11): 1439-1441.Applicant
- Shi, H., I. Nitta, et al. (1999). “Demonstration of phase correlation in multiwavelength mode-locked semiconductor diode lasers.” Optics Letters 24(4): 238-240.Applicant
- Simon, R. (1982). “The Connection between Mueller and Jones Matrices of Polarization Optics.” Optics Communications 42(5): 293-297.Applicant
- Smith, P. J. M., (2000) “Variable-Focus Microlenses as a Potential Technology for Endoscopy.” SPIE (vol. 3919), USA pp. 187-192.Applicant
- Smithies, D. J., T. Lindmo, et al. (1998). “Signal attenuation and localization in optical coherence tomography studies by Monte Carlo simulation.” Physics in Medicine and Biology 43(10): 3025-3044.Applicant
- Sorin, W. V. and D. F. Gray (1992). “Simultaneous Thickness and Group Index Measurement Using Optical Low-Coherence Reflectometry.” Ieee Photonics Technology Letters 4(1): 105-107.Applicant
- Sticker, M., C. K. Hitzenberger, et al. (2001). “Quantitative differential phase measurement and imaging in transparent and turbid media by optical coherence tomography.” Optics Letters 26(8): 518-520.Applicant
- Sticker, M., M. Pircher, et al. (2002). “En face imaging of single cell layers by differential phase-contrast optical coherence microscopy.” Optics Letters 27(13): 1126-1128.Applicant
- Stoller, P., B. M. Kim, et al. (2002). “Polarization-dependent optical second-harmonic imaging of a rat-tail tendon.” Journal of Biomedical Optics 7(2): 205-214.Applicant
- Sun, C. S. (2003). “Multiplexing of fiber-optic acoustic sensors in a Michelson interferometer configuration.” Optics Letters 28(12): 1001-1003.Applicant
- Swanson, E. A., J. A. Izatt, et al. (1993). “In-Vivo Retinal Imaging by Optical Coherence Tomography.” Optics Letters 18(21): 1864-1866.Applicant
- Takada, K., A. Himeno, et al. (1991). “Phase-Noise and Shot-Noise Limited Operations of Low Coherence Optical-Time Domain Reflectometry.” Applied Physics Letters 59(20): 2483-2485.Applicant
- Takenaka, H. (1973). “Unified Formalism for Polarization Optics by Using Group-Theory I (Theory).” Japanese Journal of Applied Physics 12(2): 226-231.Applicant
- Tanno, N., T. Ichimura, et al. (1994). “Optical Multimode Frequency-Domain Reflectometer.” Optics Letters 19(8): 587-589.Applicant
- Tan-no, N., T. Ichimura, et al. (1994). “Optical Multimode Frequency-Domain Reflectometer.” Optics Letters 19(8): 587-589.Applicant
- Targowski, P., M. Wojtkowski, et al. (2004). “Complex spectral OCT in human eye imaging in vivo.” Optics Communications 229(1-6): 79-84.Applicant
- Tearney, G. J., S. A. Boppart, et al. (1996). “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography (vol. 21, p. 543, 1996).” Optics Letters 21(12): 912-912.Applicant
- Tearney, G. J., B. E. Bouma, et al. (1996). “Rapid acquisition of in vivo biological images by use of optical coherence tomography.” Optics Letters 21(17): 1408-1410.Applicant
- Tearney, G. J., B. E. Bouma, et al. (1997). “In vivo endoscopic optical biopsy with optical coherence tomography.” Science 276(5321): 2037-2039.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1996). “Catheter-based optical imaging of a human coronary artery.” Circulation 94(11): 3013-3013.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1997). “In vivo endoscopic optical biopsy with optical coherence tomography.” Science 276(5321): 2037-9.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1997). “Optical biopsy in human gastrointestinal tissue using optical coherence tomography.” American Journal of Gastroenterology 92(10): 1800-1804.Applicant
- Tearney, G. J., M. E. Brezinski, et al. (1995). “Determination of the refractive index of highly scattering human tissue by optical coherence tomography.” Optics Letters 20(21): 2258-2260.Applicant
- Tearney, G. J., I. K. Jang, et al. (2000). “Porcine coronary imaging in vivo by optical coherence tomography.” Acta Cardiologica 55(4): 233-237.Applicant
- Tearney, G. J., R. H. Webb, et al. (1998). “Spectrally encoded confocal microscopy.” Optics Letters 23(15): 1152-1154.Applicant
- Tearney, G. J., H. Yabushita, et al. (2003). “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography.” Circulation 107(1): 113-119.Applicant
- Tower, T. T. and R. T. Tranquillo (2001). “Alignment maps of tissues: I. Microscopic elliptical polarimetry.” Biophysical Journal 81(5): 2954-2963.Applicant
- Tower, T. T. and R. T. Tranquillo (2001). “Alignment maps of tissues: II. Fast harmonic analysis for imaging.” Biophysical Journal 81(5): 2964-2971.Applicant
- Troy, T. L. and S. N. Thennadil (2001). “Optical properties of human skin in the near infrared wavelength range of 1000 to 2200 nm.” Journal of Biomedical Optics 6 (2): 167-176.Applicant
- Vabre, L., A. Dubois, et al. (2002). “Thermal-light full-field optical coherence tomography.” Optics Letters 27(7): 530-532.Applicant
- Vakhtin, A. B., D. J. Kane, et al. (2003). “Common-path interferometer for frequency-domain optical coherence tomography.” Applied Optics 42(34): 6953-6958.Applicant
- Vakhtin, A. B., K. A. Peterson, et al. (2003). “Differential spectral interferometry: an imaging technique for biomedical applications.” Optics Letters 28(15): 1332-1334.Applicant
- Vakoc, B. J., S. H. Yun, et al. (2005). “Phase-resolved optical frequency domain imaging.” Optics Express 13(14): 5483-5493.Applicant
- van Leeuwen, T. G., M. D. Kulkarni, et al. (1999). “High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography.” Optics Letters 24(22): 1584-1586.Applicant
- Vansteenkiste, N., P. Vignolo, et al. (1993). “Optical Reversibility Theorems for Polarization—Application to Remote-Control of Polarization.” Journal of the Optical Society of America a—Optics Image Science and Vision 10(10): 2240-2245.Applicant
- Vargas, O., E. K. Chan, et al. (1999). “Use of an agent to reduce scattering in skin.” Lasers in Surgery and Medicine 24(2): 133-141.Applicant
- Wang, R. K. (1999). “Resolution improved optical coherence-gated tomography for imaging through biological tissues.” Journal of Modern Optics 46(13): 1905-1912.Applicant
- Wang, X. J., T. E. Milner, et al. (1997). “Measurement of fluid-flow-velocity profile in turbid media by the use of optical Doppler tomography.” Applied Optics 36(1): 144-149.Applicant
- Wang, X. J., T. E. Milner, et al. (1995). “Characterization of Fluid-Flow Velocity by Optical Doppler Tomography.” Optics Letters 20(11): 1337-1339.Applicant
- Wang, Y. M., J. S. Nelson, et al. (2003). “Optimal wavelength for ultrahigh-resolution optical coherence tomography.” Optics Express 11(12): 1411-1417.Applicant
- Wang, Y. M., Y. H. Zhao, et al. (2003). “Ultrahigh-resolution optical coherence tomography by broadband continuum generation from a photonic crystal fiber.” Optics Letters 28(3): 182-184.Applicant
- Watkins, L. R., S. M. Tan, et al. (1999). “Determination of interferometer phase distributions by use of wavelets.” Optics Letters 24(13): 905-907.Applicant
- Wetzel, J. (2001). “Optical coherence tomography in dermatology: a review.” Skin Research and Technology 7(1): 1-9.Applicant
- Wentworth, R. H. (1989). “Theoretical Noise Performance of Coherence-Multiplexed Interferometric Sensors.” Journal of Lightwave Technology 7(6): 941-956.Applicant
- Westphal, V., A. M. Rollins, et al. (2002). “Correction of geometric and refractive image distortions in optical coherence tomography applying Fermat's principle.” Optics Express 10(9): 397-404.Applicant
- Westphal, V., S. Yazdanfar, et al. (2002). “Real-time, high velocity-resolution color Doppler optical coherence tomography.” Optics Letters 27(1): 34-36.Applicant
- Williams, P. A. (1999). “Rotating-wave-plate Stokes polarimeter for differential group delay measurements of polarization-mode dispersion.” Applied Optics 38(31): 6508-6515.Applicant
- Wojtkowski, M., T. Bajraszewski, et al. (2003). “Real-time in vivo imaging by high-speed spectral optical coherence tomography.” Optics Letters 28(19): 1745-1747.Applicant
- Wojtkowski, M., A. Kowalczyk, et al. (2002). “Full range complex spectral optical coherence tomography technique in eye imaging.” Optics Letters 27(16): 1415-1417.Applicant
- Wojtkowski, M., R. Leitgeb, et al. (2002). “In vivo human retinal imaging by Fourier domain optical coherence tomography.” Journal of Biomedical Optics 7(3): 457-463.Applicant
- Wojtkowski, M., R. Leitgeb, et al. (2002). “Fourier domain OCT imaging of the human eye in vivo.” Proc. SPIE 4619: 230-236.Applicant
- Wojtkowski, M., V. J. Srinivasan, et al. (2004). “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.” Optics Express 12(11): 2404-2422.Applicant
- Wong, B. J. F., Y. H. Zhao, et al. (2004). “Imaging the internal structure of the rat cochlea using optical coherence tomography at 0.827 mu m and 1.3 mu m.” Otolaryngology—Head and Neck Surgery 130(3): 334-338.Applicant
- Yabushita, H. B., et al. (2002) “Measurement of Thin Fibrous Caps in Atherosclerotic Plaques by Optical Coherence Tomography.” American Heart Association, INC, Circulation 2002;106;1640.Applicant
- Yang, C., A. Wax, et al. (2001). “Phase-dispersion optical tomography.” Optics Letters 26(10): 686-688.Applicant
- Yang, C., A. Wax, et al. (2001). “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics.” Optics Letters 26(16): 1271-1273.Applicant
- Yang, C. H., A. Wax, et al. (2001). “Phase-dispersion optical tomography.” Optics Letters 26(10): 686-688.Applicant
- Yang, C. H., A. Wax, et al. (2000). “Interferometric phase-dispersion microscopy.” Optics Letters 25(20): 1526-1528.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2002). “Improved phase-resolved optical Doppler tomography using the Kasai velocity estimator and histogram segmentation.” Optics Communications 208(4-6): 209-214.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance.” Optics Express 11(7): 794-809.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis.” Optics Express 11(14): 1650-1658.Applicant
- Yang, V. X. D., M. L. Gordon, et al. (2003). “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part III): in vivo endoscopic imaging of blood flow in the rat and human gastrointestinal tracts.” Optics Express 11(19): 2416-2424.Applicant
- Yang, V. X. D., B. Qi, et al. (2003). “In vivo feasibility of endoscopic catheter-based Doppler optical coherence tomography.” Gastroenterologv 124(4): A49-A50.Applicant
- Yao, G. and L. H. V. Wang (2000). “Theoretical and experimental studies of ultrasound-modulated optical tomography in biological tissue.” Applied Optics 39(4): 659-664.Applicant
- Yazdanfar, S. and J. A. Izatt (2002). “Self-referenced Doppler optical coherence tomography.” Optics Letters 27(23): 2085-2087.Applicant
- Yazdanfar, S., M. D. Kulkarni, et al. (1997). “High resolution imaging of an in vivo cardiac dynamics using color Doppler optical coherence tomography.” Optics Express 1 (13) : 424-431.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2000). “Imaging and velocimetry of the human retinal circulation with color Doppler optical coherence tomography.” Optics Letters 25(19): 1448-1450.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2000). “Noninvasive imaging and velocimetry of human retinal blood flow using color Doppler optical coherence tomography.” Investigative Ophthalmology & Visual Science 41(4): S548-S548.Applicant
- Yazdanfar, S., A. M. Rollins, et al. (2003). “In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography.” Archives of Ophthalmoloqy 121(2): 235-239.Applicant
- Yazdanfar, S., C. H. Yang, et al. (2005). “Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound.” Optics Express 13(2): 410-416.Applicant
- Yun, S. H., C. Boudoux, et al. (2004). “Extended-cavity semiconductor wavelength-swept laser for biomedical imaging.” Ieee Photonics Technology Letters 16(1): 293-295.Applicant
- Yun, S. H., C. Boudoux, et al. (2003). “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter.” Optics Letters 28(20): 1981-1983.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts.” Optics Express 12(23): 5614-5624.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting.” Optics Express 12(20): 4822-4828.Applicant
- Yun, S. H., G. J. Tearney, et al. (2004). “Motion artifacts in optical coherence tomography with frequency-domain ranging.” Optics Express 12(13): 2977-2998.Applicant
- Zhang, J., J. S. Nelson, et al. (2005). “Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator.” Optics Letters 30(2): 147-149.Applicant
- Zhang, Y., M. Sato, et al. (2001). “Numerical investigations of optimal synthesis of several low coherence sources for resolution improvement.” Optics Communications 192(3-6): 183-192.Applicant
- Zhang, Y., M. Sato, et al. (2001). “Resolution improvement in optical coherence tomography by optimal synthesis of light-emitting diodes.” Optics Letters 26(4): 205-207.Applicant
- Zhao, Y., Z. Chen, et al. (2002). “Real-time phase-resolved functional optical coherence tomography by use of the optical Hilbert transformation.” Optics Letters 27(2): 98-100.Applicant
- Zhao, Y. H., Z. P. Chen, et al. (2000). “Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow.” Optics Letters 25(18): 1358-1360.Applicant
- Zhao, Y. H., Z. P. Chen, et al. (2000). “Phase resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity.” Optics Letters 25(2): 114-116.Applicant
- Zhou, D., P. R. Prucnal, et al. (1998). “A widely tunable narrow linewidth semiconductor fiber ring laser.” IEEE Photonics Technology Letters 10(6): 781-783.Applicant
- Zuluaga, A. F. and R. Richards-Kortum (1999). “Spatially resolved spectral interferometry for determination of subsurface structure.” Optics Letters 24(8): 519-521.Applicant
- Zvyagin, A. V., J. B. FitzGerald, et al. (2000). “Real-time detection technique for Doppler optical coherence tomography.” Optics Letters 25(22): 1645-1647.Applicant
- Marc Nikles et al., “Brillouin gain spectrum characterization in single-mode optical fibers”, Journal of Lightwave Technology 1997, 15 (10): 1842-1851.Applicant
- Tsuyoshi Sonehara et al., “Forced Brillouin Spectroscopy Using Frequency-Tunable Continuous-Wave Lasers”, Physical Review Letters 1995, 75 (23): 4234-4237.Applicant
- Hajime Tanaka et al., “New Method of Superheterodyne Light Beating Spectroscopy for Brillouin-Scattering Using Frequency-Tunable Lasers”, Physical Review Letters 1995, 74 (9): 1609-1612.Applicant
- Webb RH et al. “Confocal Scanning Laser Ophthalmoscope”, Applied Optics 1987, 26 (8): 1492-1499.Applicant
- Andreas Zumbusch et al. “Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering”, Physical Review Letters 1999, 82 (20): 4142-4145.Applicant
- Katrin Kneipp et al., “Single molecule detection using surface-enhanced Raman scattering (SERS)”, Physical Review Letters 1997, 78 (9): 1667-1670.Applicant
- K.J. Koski et al., “Brillouin imaging” Applied Physics Letters 87, 2005.Applicant
- Boas et al., “Diffusing temporal light correlation for burn diagnosis”, SPIE, 1999, 2979:468-477.Applicant
- David J. Briers, “Speckle fluctuations and biomedical optics: implications and applications”, Optical Engineering, 1993, 32(2):277-283.Applicant
- Clark et al., “Tracking Speckle Patterns with Optical Correlation”, SPIE, 1992, 1772:77-87.Applicant
- Facchini et al., “An endoscopic system for DSPI”, Optik, 1993, 95(1):27-30.Applicant
- Hrabovsky, M., “Theory of speckle dispacement and decorrelation: application in mechanics”, SPIE, 1998, 3479:345-354.Applicant
- Sean J. Kirkpatrick et al., “Micromechanical behavior of cortical bone as inferred from laser speckle data”, Journal of Biomedical Materials Research, 1998, 39(3):373-379.Applicant
- Sean J. Kirkpatrick et al., “Laser speckle microstrain measurements in vascular tissue”, SPIE, 1999, 3598:121-129.Applicant
- Loree et al., “Mechanical Properties of Model Atherosclerotic Lesion Lipid Pools”, Arteriosclerosis and Thrombosis, 1994, 14(2):230-234.Applicant
- Podbielska, H. “Interferometric Methods and Biomedical Research”, SPIE, 1999, 2732:134-141.Applicant
- Richards-Kortum et al., “Spectral diagnosis of atherosclerosis using an optical fiber laser catheter”, American Heart Journal, 1989, 118(2):381-391.Applicant
- Ruth, B. “blood flow determination by the laser speckle method”, Int J Microcirc: Clin Exp, 1990, 9:21-45.Applicant
- Shapo et al., “Intravascular strain imaging: Experiments on an Inhomogeneous Phantom”, IEEE Ultrasonics Symposium 1996, 2:1177-1180.Applicant
- Shapo et al., “Ultrasonic displacement and strain imaging of coronary arteries with a catheter array”, IEEE Ultrasonics Symposium 1995, 2:1511-1514.Applicant
- Thompson et al., “Imaging in scattering media by use of laser speckle”, Opt. Soc. Am. A., 1997, 14(9):2269-2277.Applicant
- Thompson et al., “Diffusive media characterization with laser speckle”, Applied Optics, 1997, 36(16):3726-3734.Applicant
- Tuchin, Valery V., “Coherent Optical Techniques for the Analysis of Tissue Structure and Dynamics,” Journal of Biomedical Optics, 1999, 4(1):106-124.Applicant
- M. Wussling et al., “Laser diffraction and speckling studies in skeletal and heart muscle”, Biomed, Biochim, Acta, 1986, 45(1/2):S 23-S 27.Applicant
- T. Yoshimura et al., “Statistical properties of dynamic speckles”, J. Opt. Soc. Am A. 1986, 3(7):1032-1054.Applicant
- Zimnyakov et al., “Spatial speckle correlometry in applications to tissue structure monitoring”, Applied Optics 1997, 36(22): 5594-5607.Applicant
- Zimnyakov et al., “A study of statistical properties of partially developed speckle fields as applied to the diagnosis of structural changes in human skin”, Optics and Spectroscopy, 1994, 76(5): 747-753.Applicant
- Zimnyakov et al., “Speckle patterns polarization analysis as an approach to turbid tissue structure monitoring”, SPIE 1999, 2981:172-180.Applicant
- Ramasamy Manoharan et al., “Biochemical analysis and mapping of atherosclerotic human artery using FT-IR microspectroscopy”, Atherosclerosis, May 1993, 181-1930.Applicant
- N.V. Salunke et al., “Biomechanics of Atherosclerotic Plaque” Critical Reviews™ in Biomedical Engineering 1997, 25(3):243-285.Applicant
- D. Fu et al., “Non-invasive quantitative reconstruction of tissue elasticity using an iterative forward approach”, Phys. Med. Biol. 2000 (45): 1495-1509.Applicant
- S.B. Adams Jr. et al., “The use of polarization sensitive optical coherence tomography and elastography to assess connective tissue”, Optical Soc. of American Washington 2002, p. 3.Applicant
- International Search Report for International Patent application No. PCT/US2005/039740 published Feb. 21, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/039740 published Feb. 21, 2006.Applicant
- International Search Report for International Patent application No. PCT/US2005/030294 published Aug. 22, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/043951 published Apr. 6, 2006.Applicant
- International Search Report for International Patent application No. PCT/US2005/043951 published Apr. 6, 2006.Applicant
- Erdelyi et al. “Generation of diffraction-free beams for applications in optical microlithography”, J. Vac. Sci. Technol. B 15 (12), Mar./Apr. 1997, pp. 287-292.Applicant
- International Search Report for International Patent application No. PCT/US2005/023664 published Oct. 12, 2005.Applicant
- International Written Opinion for International Patent application No. PCT/US2005/023664 published Oct. 12, 2005.Applicant
- Tearney et al., “Spectrally encoded miniature endoscopy” Optical Society of America; Optical Letters vol. 27, No. 6, Mar. 15, 2002; pp. 412-414.Applicant
- Yelin et al., “Double-clad Fiber for Endoscopy” Optical Society of America; Optical Letters vol. 29, No. 20, Oct. 16, 2005; pp. 2408-2410.Applicant
- International Search Report for International Patent application No. PCT/US2001/049704 published Dec. 10, 2002.Applicant
- International Search Report for International Patent application No. PCT/US2004/039454 published May 11, 2005.Applicant
- International Written Opinion for International Patent application No. PCT/US2004/039454 published May 11, 2005.Applicant
- PCT International Preliminary Report on Patentability for International Application No. PCT/US2004/038404 dated Jun. 2, 2006.Applicant
- Notice of Reasons for Rejection and English translation for Japanese Patent Application No. 2002-538830 dated May 12, 2008.Applicant
- Office Action dated Aug. 24, 2006 for U.S. Appl. No. 10/137,749.Applicant
- Barry Cense et al., “Spectral-domain polarization-sensitive optical coherence tomography at 850nm”, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, pp. 159-162.Applicant
- A. Ymeti et al., “Integration of microfluidics with a four-channel integrated optical Young interferometer immunosensor”, Biosensors and Bioelectronics, Elsevier Science Publishers, 2005, pp. 1417-1421.Applicant
- PCT International Search Report for Application No. PCT/US2006/018865 filed May 5, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2006/018865 filed May 5, 2006.Applicant
- John M. Poneros, “Diagnosis of Barrett's esophagus using optical coherence tomography”, Gastrointestinal Endoscopy clinics of North America, 14 (2004) pp. 573-588.Applicant
- P.F. Escobar et al., “Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva”, Int. Journal of Gynecological Cancer 2004, 14, pp. 470-474.Applicant
- Ko T et al., “Ultrahigh resolution in vivo versus ex vivo OCT imaging and tissue preservation”, Conference on Lasers and electro-optics, 2001, pp. 252-253.Applicant
- Paul M. Ripley et al., “A comparison of Artificial Intelligence techniques for spectral classification in the diagnosis of human pathologies based upon optical biopsy”, Journal of Optical Society of America, 2000, pp. 217-219.Applicant
- Wolfgang Drexler et al., “Ultrahigh-resolution optical coherence tomography”, Journal of Biomedical Optics Spie USA, 2004, pp. 47-74.Applicant
- PCT International Search Report for Application No. PCT/US2006/016677 filed Apr. 28, 2006.Applicant
- International Written Opinion for International Patent application No. PCT/US2006/016677 filed Apr. 28, 2006.Applicant
- Office Action dated Nov. 13, 2006 for U.S. Appl. No. 10/501,268.Applicant
- Office Action dated Nov. 20, 2006 for U.S. Appl. No. 09/709,162.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2004/023585 filed Jul. 23, 2004.Applicant
- Office Action dated Dec. 6, 2006 for U.S. Appl. No. 10/997,789.Applicant
- Elliott, K. H. “The use of commercial CCD cameras as linear detectors in the physics undergraduate teaching laboratory”, European Journal of Physics, 1998, pp. 107-117.Applicant
- Lauer, V. “New approach to optical diffraction tomography yielding a vector equation of diffraction tomography and a novel tomographic microscope”, Journal of Microscopy vol. 205, Issue 2, 2002, pp. 165-176.Applicant
- Yu, P. et al. “Imaging of tumor necroses using full-frame optical coherence imaging”, Proceedings of SPIE vol. 4956, 2003, pp. 34-41.Applicant
- Zhao, Y. et al. “Three-dimensional reconstruction of in vivo blood vessels in human skin using phase-resolved optical Doppler tomography”, IEEE Journal of Selected Topics in Quantum Electronics 7.6 (2001): 931-935.Applicant
- Office Action dated Dec. 18, 2006 for U.S. Appl. No. 10/501,276.Applicant
- Devesa, Susan S. et al. (1998) “Changing Patterns in the Incidence of Esophegeal and Gastric Carcinoma in the United States.” American Cancer Society vol. 83, No. 10 pp. 2049-2053.Applicant
- Barr, H et al. (2005) “Endoscopic Therapy for Barrett's Oesophaugs” Gut vol. 54:875-884.Applicant
- Johnston, Mark H.(2005) “Technology Insight: Ablative Techniques for Barrett's Esophagus—Current and Emerging Trends” www.Nature.com/clinicalpractice/gasthep.Applicant
- Falk, Gary W. et al. (1997) “Surveillance of Patients with Barrett's Esophagus for Dysplasia and Cancer with Ballon Cytology” Gastrorenterology vol. 112, pp. 1787-1797.Applicant
- Sepchler, Stuart Jon. (1997) “Barrett's Esophagus: Should We Brush Off this Balloning Problem?” Gastroenterology vol. 112, pp. 2138-2152.Applicant
- Froehly, J. et al. (2003) “Multiplexed 3D Imaging Using Wavelength Encoded Spectral Interferometry: A Proof of Principle” Optics Communications vol. 222, pp. 127-136.Applicant
- Kubba A.K. et al. (1999) “Role of p53 Assessment in Management of Barrett's Esophagus” Digestive Disease and Sciences vol. 44, No. 4. pp. 659-667.Applicant
- Reid, Brian J. (2001) “p53 and Neoplastic Progression in Barrett's Esophagus” The American Journal of Gastroenterology vol. 96, No. 5, pp. 1321-1323.Applicant
- Sharma, P. et al.(2003) “Magnification Chromoendoscopy for the Detection of Intestinal Metaplasia and Dysplasia in Barrett's Oesophagus” Gut vol. 52, pp. 24-27.Applicant
- Kuipers E.J et al. (2005) “Diagnostic and Therapeutic Endoscopy” Journal of Surgical Oncology vol. 92, pp. 203-209.Applicant
- Georgakoudi, Irene et al. (2001) “Fluorescence, Reflectance, and Light-Scattering Spectroscopy for Evaluating Dysplasia in Patients with Barrett's Esophagus” Gastroenterology vol. 120, pp. 1620-1629.Applicant
- Adrain, Alyn L. et al. (1997) “High-Resolution Endoluminal Sonography is a Sensitive Modality for the Identification of Barrett's Meaplasia” Gastrointestinal Endoscopy vol. 46, No. 2, pp. 147-151.Applicant
- Canto, Marcia Irene et al (1999) “Vital Staining and Barrett's Esophagus” Gastrointestinal Endoscopy vol. 49, No. 3, part 2, pp. 12-16.Applicant
- Evans, John A. et al. (2006) “Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett's Esophagus” Clinical Gastroenterology and Hepatology vol. 4, pp. 38-3.Applicant
- Poneros, John M. et al. (2001) “Diagnosis of Specialized Intestinal Metaplasia by Optical Coherence Tomography” Gastroenterology vol. 120, pp. 7-12.Applicant
- Ho, W. Y. et al. (2005) “115 KHz Tuning Repetition Rate Ultrahigh-Speed Wavelength-Swept Semiconductor Laser” Optics Letters col. 30, No. 23, pp. 3159-3161.Applicant
- Brown, Stanley B. et al. (2004) “The Present and Future Role of Photodynamic Therapy in Cancer Treatment” The Lancet Oncology vol. 5, pp. 497-508.Applicant
- Boogert, Jolanda Van Den et al. (1999) “Endoscopic Ablation Therapy for Barrett's Esophagua with High-Grade Dysplasia: A Review” The American Journal of Gastroenterology vol. 94, No. 5, pp. 1153-1160.Applicant
- Sampliner, Richard E. et al. (1996) “Reversal of Barrett's Esophagus with Acid Suppression and Multipolar Electrocoagulation: Preliminary Results” Gastrointestinal Endoscopy vol. 44, No. 5, pp. 532-535.Applicant
- Sampliner, Richard E. (2004) “Endoscopic Ablative Therapy for Barrett's Esophagus: Current Status” Gastrointestinal Endoscopy vol. 59, No. 1, pp. 66-69.Applicant
- Soetikno, Roy M. et al. (2003) “Endoscopic Mucosal resection” Gastrointestinal Endoscopy vol. 57, No. 4, pp. 567-579.Applicant
- Ganz, Robert A. et al. (2004) “Complete Ablation of Esophageal Epithelium with a Balloon-based Bipolar Electrode: A Phased Evaluation in the Porcine and in the Human Esophagus” Gastrointestinal Endoscopy vol. 60, No. 6, pp. 1002-1010.Applicant
- Pfefer, Jorje at al. (2006) “Performance of the Aer-O-Scope, a Pneumatic, Self Propelling, Self Navigating Colonoscope in Animal Experiments” Gastrointestinal Endoscopy vol. 63, No. 5, pp. AB223.Applicant
- Overholt, Bergein F. et al. (1999) “Photodynamic Therapy for Barrett's Esophagus: Follow-Up in 100 Patients” Gastrointestinal Endoscopy vol. 49, No. 1, pp. 1-7.Applicant
- Vogel, Alfred et al. (2003) “Mechanisms of Pulsed Laser Ablation of Biological Tissues” American Chemical Society vol. 103, pp. 577-644.Applicant
- McKenzie, A. L. (1990) “Physics of Thermal Processes in Laser-Tissue Interaction” Phys. Med. Biol vol. 35, No. 9, pp. 1175-1209.Applicant
- Anderson, R. Rox et al. (1983) “Selective Photothermolysis” Precise Microsurgery by Selective Absorption of Pulsed Radiation Science vol. 220, No. 4596, pp. 524-527.Applicant
- Jacques, Steven L. (1993) “Role of Tissue Optics and Pulse Duration on Tissue Effects During High-Power Laser Irradiation” Applied Optics vol. 32, No. 13, pp. 2447-2454.Applicant
- Nahen, Kester et al. (1999) “Investigations on Acosustic On-Line Monitoring of IR Laser Ablation of burned Skin” Lasers in Surgery and Medicine vol. 25, pp. 69-78.Applicant
- Jerath, Maya R. et al. (1993) “Calibrated Real-Time Control of Lesion Size Based on Reflectance Images” Applied Optics vol. 32, No. 7, pp. 1200-1209.Applicant
- Jerath, Maya R. et al (1992) “Dynamic Optical Property Changes: Implications for Reflectance Feedback Control of Photocoagulation” Journal of Photochemical,.Photobiology, B: Biol vol. 16, pp. 113-126.Applicant
- Deckelbaum, Lawrence I. (1994) “Coronary Laser Angioplasty” Lasers in Surgery and Medicine vol. 14, pp. 101-110.Applicant
- Kim, B.M. et al. (1998) “Optical Feedback Signal for Ultrashort Laser Pulse Ablation of Tissue” Applied Surface Science vol. 127-129, pp. 857-862.Applicant
- Brinkman, Ralf et al. (1996) “Analysis of Cavitation Dynamics During Pulsed Laser Tissue Ablation by Optical On-Line Monitoring” IEEE Journal of Selected Topics in Quantum Electronics vol. 2, No. 4, pp. 826-835.Applicant
- Whelan, W.M. et al. (2005) “A novel Strategy for Monitoring Laser Thermal Therapy Based on Changes in Optothermal Properties of Heated Tissues” International Journal of Thermophysics vol. 26., No. 1, pp. 233-241.Applicant
- Thomsen, Sharon et al. (1990) “Microscopic Correlates of Macroscopic Optical Property Changes During Thermal Coagulation of Myocardium” SPIE vol. 1202, pp. 2-11.Applicant
- Khan, Misban Huzaira et al. (2005) “Intradermally Focused Infrared Laser Pulses: Thermal Effects at Defined Tissue Depths” Lasers in Surgery and Medicine vol. 36, pp. 270-280.Applicant
- Neumann, R.A. et al. (1991) “Enzyme Histochemical Analysis of Cell Viability After Argon Laser-Induced Coagulation Necrosis of the Skin” Journal of the American Academy of Dermatology vol. 25, No. 6, pp. 991-998.Applicant
- Nadkarni, Seemantini K. et al (2005) “Charaterization of Atherosclerotic Plaques by Laser Speckle Imaging” Circulation vol. 112, pp. 885-892.Applicant
- Zimnyakov, Dmitry A. et al (2002) “Speckle-Contrast Monitoring of Tissue Thermal Modification” Applied Optics vol. 41, No. 28, pp. 5989-5996.Applicant
- Morelli, J.G., et al (1986) “Tunable Dye Laser (577 nm) Treatment of Port Wine Stains” Lasers in Surgery and Medicine vol. 6, pp. 94-99.Applicant
- French, P.M.W. et al. (1993) “Continuous-wave Mode-Locked Cr4+: YAG Laser” Optics Letters vol. 18, No. 1, pp. 39-41.Applicant
- Sennaroglu, Alphan at al. (1995) “Efficient Continuous-Wave Chromium-Doped YAG Laser” Journal of Optical Society of America vol. 12, No. 5, pp. 930-937.Applicant
- Bouma, B et al. (1994) “Hybrid Mode Locking of a Flash-Lamp-Pumped Ti: Al2O3 Laser” Optics Letters vol. 19, No. 22, pp. 1858-1860.Applicant
- Bouma, B et al. (1995) “High Resolution Optical Coherence Tomography Imaging Using a Mode-Locked Ti: Al2O3 Laser Source” Optics Letters vol. 20, No. 13, pp. 1486-1488.Applicant
- Fernández, Cabrera Delia et al. “Automated detection of retinal layer structures on optical coherence tomography images”, Optics Express vol. 13, No. 25, Oct. 4, 2005, pp. 10200-10216.Applicant
- Ishikawa, Hiroshi et al. “Macular Segmentation with optical coherence tomography”, Investigative Ophthalmology & Visual Science, vol. 46, No. 6, Jun. 2005, pp. 2012-2017.Applicant
- Hariri, Lida P. et al. “Endoscopic Optical Coherence Tomography and Laser-Induced Fluorescence Spectroscopy in a Murine Colon Cancer Model”, Laser in Surgery and Medicine, vol. 38, 2006, pp. 305-313.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2006/031905 dated May 3, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060481 dated May 23, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060717 dated May 24, 2007.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060319 dated Jun. 6, 2007.Applicant
- D. Yelin et al., “Three-dimensional imaging using spectral encoding heterodyne interferometry”, Optics Letters, Jul. 15, 2005, vol. 30, No. 14, pp. 1794-1796.Applicant
- Akiba, Masahiro et al. “En-face optical coherence imaging for three-dimensional microscopy”, SPIE, 2002, pp. 8-15.Applicant
- Office Action dated Aug. 10, 2007 for U.S. Appl. No. 10/997,789.Applicant
- Office Action dated Feb. 2, 2007 for U.S. Appl. No. 11/174,425.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060657 dated Aug. 13, 2007.Applicant
- Lewis, Neil E. et al., (2006) “Applications of Fourier Transform Infrared Imaging Microscopy in Neurotoxicity”, Annals New York Academy of Sciences, Dec. 17, 2006, vol. 820, pp. 234-246.Applicant
- Joo, Chu lmin et a l., Spectral-domain optical coherence phase microscopy for quantitative phase-contrast i maging, Optics Letters, Aug. 15, 2005, vol. 30, No. 1 6, pp. 2131-2133.Applicant
- Guo, Bujin et al., “Laser-based mid-infrared reflectance imaging of biological tissues”, Optics Express, Jan. 12, 2004, vol. 12, No. 1, pp. 208-219.Applicant
- Office Action dated Mar. 28, 2007 for U.S. Appl. No. 11/241,907.Applicant
- Office Action dated May 23, 2007 for U.S. Appl. No. 10/406,751.Applicant
- Office Action dated May 23, 2007 for U.S. Appl. No. 10/551,735.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/061815 dated Aug. 2, 2007.Applicant
- Sir Randall, John et al., “Brillouin scattering in systems of biological significance”, Phil. Trans. R. Soc. Lond. A 293, 1979, pp. 341-348.Applicant
- Takagi, Yasunari, “Application of a microscope to Brillouin scattering spectroscopy”, Review of Scientific Instruments, No. 12, Dec. 1992, pp. 5552-5555.Applicant
- Lees, S. et al., “Studies of Compact Hard Tissues and Collagen by Means of Brillouin Light Scattering”, Connective Tissue Research, 1990, vol. 24, pp. 187-205.Applicant
- Berovic, N. “Observation of Brillion scattering from single muscle fibers”, European Biophysics Journal, 1989, vol. 17, pp. 69-74.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/062465 dated Aug. 8, 2007.Applicant
- Pythila John W. et al., “Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometry”, Optics Society of America, 2004.Applicant
- Pyhtila John W. et al., “Determining nuclear morphology using an improved angle-resolved low coherence interferometry system”, Optics Express, Dec. 15, 2003, vol. 11, No. 25, pp. 3473-3484.Applicant
- Desjardins A.E., et al., “Speckle reduction in OCT using massively-parallel detection and frequency-domain ranging”, Optics Express, May 15, 2006, vol. 14, No. 11, pp. 4736-4745.Applicant
- Nadkarni, Seemantini K., et al., “Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images”, Journal of Biomedical Optics, vol. 11 Mar./Apr. 2006, pp. 021006-1-021006-8.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/066017 dated Aug. 30, 2007.Applicant
- Yamanari M. et al., “Polarization sensitive Fourier domain optical coherence tomography with continuous polarization modulation”, Proc. of SPIE, vol. 6079, 2006.Applicant
- Zhang Jun et al., “Full range polarization-sensitive Fourier domain optical coherence tomography”, Optics Express, Nov. 29, 2004, vol. 12, No. 24, pp. 6033-6039.Applicant
- European Patent Office Search report for Application No. 01991092.6-2305 dated Jan. 12, 2006.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/060670 dated Sep. 21, 2007.Applicant
- J. M. Schmitt et al., (1999) “Speckle in Optical Coherence Tomography: An Overview”, SPIE vol. 3726, pp. 450-461.Applicant
- Office Action dated Oct. 11, 2007 for U.S. Appl. No. 11/534,095.Applicant
- Office Action dated Oct. 9, 2007 for U.S. Appl. No. 09/709,162.Applicant
- Notice of Allowance dated Oct. 3, 2007 for U.S. Appl. No. 11/225,840.Applicant
- Siavash Yazdanfar et al., “In Vivo imaging in blood flow in human retinal vessels using color Doppler optical coherence tomography”, SPIE, 1999 vol. 3598, pp. 177-184.Applicant
- Office Action dated Oct. 30, 2007 for U.S. Appl. No. 11/670,069.Applicant
- Tang C. L. et al., “Wide-band electro-optical tuning of semiconductor lasers”, Applied Physics Letters, vol. 30, No. 2, Jan. 15, 1977, pp. 113-116.Applicant
- Tang C. L. et al., “Transient effects in wavelength-modulated dye lasers”, Applied Physics Letters, vol. 26, No. 9, May 1, 1975, pp. 534-537.Applicant
- Telle M. John, et al., “Very rapid tuning of cw dye laser”, Applied Physics Letters, vol. 26, No. 10, May 15, 1975, pp. 572-574.Applicant
- Telle M. John, et al., “New method for electro-optical tuning of tunable lasers”, Applied Physics Letters, vol. 24, No. 2, Jan. 15, 1974, pp. 85-87.Applicant
- Schmitt M. Joseph et al. “OCT elastography: imaging microscopic deformation and strain of tissue”, Optics Express, vol. 3, No. 6, Sep. 14, 1998, pp. 199-211.Applicant
- M. Gualini Muddassir et al., “Recent Advancements of Optical Interferometry Applied to Medicine”, IEEE Transactions on Medical Imaging, vol. 23, No. 2, Feb. 2004, pp. 205-212.Applicant
- Maurice L. Roch et al. “Noninvasive Vascular Elastography: Theoretical Framework”, IEEE Transactions on Medical Imaging, vol. 23, No. 2, Feb. 2004, pp. 164-180.Applicant
- Kirkpatrick J. Sean et al. “Optical Assessment of Tissue Mechanical Properties”, Proceedings of the SPIE—The International Society for Optical Engineering SPIE—vol. 4001, 2000, pp. 92-101.Applicant
- Lisauskas B. Jennifer et al., “Investigation of Plaque Biomechanics from Intravascular Ultrasound Images using Finite Element Modeling”, Proceedings of the 19th International Conference—IEEE Oct. 30-Nov. 2, 1997, pp. 887-888.Applicant
- Parker K. J. et al., “Techniques for Elastic Imaging: A Review”, IEEE Engineering in Medicine and Biology, Nov./Dec. 1996, pp. 52-59.Applicant
- European Patent Office Search Report dated Nov. 20, 2007 for European Application No. 05791226.3.Applicant
- Dubois Arnaud et al., “Ultrahigh-resolution OCT using white-light interference microscopy”, Proceedings of SPIE, 2003, vol. 4956, pp. 14-21.Applicant
- Office Action dated Jan. 3, 2008 for U.S. Appl. No. 10/997,789.Applicant
- Office Action dated Dec. 21, 2007 for U.S. Appl. No. 11/264,655.Applicant
- Office Action dated Dec. 18, 2007 for U.S. Appl. No. 11/288,994.Applicant
- Office Action dated Jan. 10, 2008 for U.S. Appl. No. 11/435,228.Applicant
- Office Action dated Jan. 10, 2008 for U.S. Appl. No. 11/410,937.Applicant
- Office Action dated Jan. 11, 2008 for U.S. Appl. No. 11/445,990.Applicant
- Office Action dated Feb. 4, 2008 for U.S. Appl. No. 10/861,179.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/061463 dated Jan. 23, 2008.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/061481 dated Mar. 17, 2008.Applicant
- PCT International Search Report and Written Opinion for Application No. PCT/US2007/078254 dated Mar. 28, 2008.Applicant
- Sadhwani, Ajay et al., “Determination of Teflon thickness with laser speckle I. Potential for burn depth diagnosis”, Optical Society of America, 1996, vol. 35, No. 28, pp. 5727-5735.Applicant
- C.J. Stewart et al., “A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging”, Elsevier Ltd., 2005, vol. 31, pp. 744-752.Applicant
- G. J. Tearney et al., “Atherosclerotic plaque characterization by spatial and temporal speckle pattern analysis”, CLEO 2001, vol. 56, pp. 307-307.Applicant
- PCT International Search Report for Application No. PCT/US2007/068233 dated Feb. 21, 2008.Applicant
- PCT International Search Report for Application No. PCT/US2007/060787 dated Mar. 18, 2008.Applicant
- Statement under Article 19 and Reply to PCT Written Opinion for PCT International Application No. PCT/US2005/043951 dated Jun. 6, 2006.Applicant
- PCT International Preliminary Report on Patentability for Application No. PCT/US2005/043951 dated Jun. 7, 2007.Applicant
- Liptak David C. et al., (2007) “On the Development of a Confocal Rayleigh-Brillouin Microscope” American Institute of Physics vol. 78, 016106.Applicant
- Office Action mailed Oct. 1, 2008 for U.S. Appl. No. 11/955,986.Applicant
- Invitation of Pay Additional Fees mailed Aug. 7, 2008 for International Application No. PCT/US2008/062354.Applicant
- Invitation of Pay Additional Fees mailed Jul. 20, 2008 for International Application No. PCT/US2007/081982.Applicant
- International Search Report and Written Opinion mailed Mar. 7, 2006 for PCT/US2005/035711.Applicant
- International Search Report and Written Opinion mailed Jul. 18, 2008 for PCT/US2008/057533.Applicant
- Aizu, Y et al. (1991) “Bio-Speckle Phenomena and Their Application to the Evaluation of Blood Flow” Optics and Laser Technology, vol. 23, No. 4, Aug. 1, 1991.Applicant
- Richards G.J. et al. (1997) “Laser Speckle Contrast Analysis (LASCA): A Technique for Measuring Capillary Blood Flow Using the First Order Statistics of Laser Speckle Patterns” Apr. 2, 1997.Applicant
- Gonick, Maria M., et al (2002) “Visualization of Blood Microcirculation Parameters in Human Tissues by Time Integrated Dynamic Speckles Analysis” vol. 972, No. 1, Oct. 1, 2002.Applicant
- International Search Report and Written Opinion mailed Jul. 4, 2008 for PCT/US2008/051432.Applicant
- Jonathan, Enock (2005) “Dual Reference Arm Low-Coherence Interferometer-Based Reflectometer for Optical Coherence Tomography (OCT) Application” Optics Communications vol. 252.Applicant
- Motaghian Nezam, S.M.R. (2007) “increased Ranging Depth in optical Frequency Domain Imaging by Frequency Encoding” Optics Letters, vol. 32, No. 19, Oct. 1, 2007.Applicant
- Office Action dated Jun. 30, 2008 for U.S. Appl. No. 11/670,058.Applicant
- Office Action dated Jul. 7, 2008 for U.S. Appl. No. 10/551,735.Applicant
- Australian Examiner's Report mailed May 27, 2008 for Australian patent application No. 2003210669.Applicant
- Notice of Allowance mailed Jun. 4, 2008 for U.S. Appl. No. 11/174,425.Applicant
- European communication dated May 15, 2008 for European patent application No. 05819917.5.Applicant
- International Search Report and Written Opinion mailed Jun. 10, 2008 for PCT/US2008/051335.Applicant
- Oh. W.Y. et al (2006) “Ultrahigh-Speed Optical Frequency Domain Imaging and Application to laser Ablation Monitoring” Applied Physics Letters, vol. 88.Applicant
- Office Action dated Aug. 21, 2008 for U.S. Appl. No. 11/505,700.Applicant
- Sticker, Markus (2002) En Face Imaging of Single Cell layers by Differential Phase-Contrast Optical Coherence Microscopy) Optics Letters, col. 27, No. 13, Jul. 1, 2002.Applicant
- International Search Report and Written Opinion dated Jul. 17, 2008 for International Application No. PCT/US2008/057450.Applicant
- International Search Report and Written Opinion dated Aug. 11, 2008 for International Application No. PCT/US2008/058703.Applicant
- US National Library of Medicine (NLM), Bethesda, MD, US; Oct. 2007, “Abstracts of the 19th Annual Symposium of Transcatheter Cardiovascular Therapeutics, Oct. 20-25, 2007, Washington, DC, USA.”Applicant
- International Search Report and Written Opinion dated May 26, 2008 for International Application No. PCT/US2008/051404.Applicant
- Office Action dated Aug. 25, 2008 for U.S. Appl. No. 11/264,655.Applicant
- Office Action dated Sep. 11, 2008 for U.S. Appl. No. 11/624,334.Applicant
- Office Action dated Aug. 21, 2008 for U.S. Appl. No. 11/956,079.Applicant
- Gelikono, V. M. et al. Oct. 1, 2004 “Two-Wavelength Optical Coherence Tomography” Radio physics and Quantum Electronics, Kluwer Academic Publishers—Consultants. vol. 47, No. 10-1.Applicant
- International Search Report and Written Opinion for PCT/US2007/081982 dated Oct. 19, 2007.Applicant
- Database Compendex Engineering Information, Inc., New York, NY, US; Mar. 5, 2007, Yelin, Dvir et al: “Spectral-Domain Spectrally-Encoded Endoscopy”.Applicant
- Database Biosis Biosciences Information Service, Philadelphia, PA, US; Oct. 2006, Yelin D. et al: “Three-Dimensional Miniature Endoscopy”.Applicant
- International Search Report and Written Opinion mailed Mar. 14, 2005 for PCT/US2004/018045.Applicant
- Notification of the international Preliminary Report on Patentability mailed Oct. 21, 2005.Applicant
- Shim M.G. et al., “Study of Fiber-Optic Probes for In vivo Medical Raman Spectroscopy” Applied Spectroscopy. vol. 53, No. 6, Jun. 1999.Applicant
- Bingid U. et al., “Fibre-Optic Laser-Assisted Infrared Tumour Diagnostics (FLAIR); Infrared Tomour Diagnostics” Journal of Physics D. Applied Physics, vol. 38, No. 15, Aug. 7, 2005.Applicant
- Jun Zhang et al. “Full Range Polarization-Sensitive Fourier Domain Optical Coherence Tomography” Optics Express, vol. 12, No. 24. Nov. 29, 2004.Applicant
- Yonghua et al., “Real-Time Phase-Resolved Functional Optical Hilbert Transformation” Optics Letters, vol. 27, No. 2, Jan. 15, 2002.Applicant
- Siavash et al., “Self-Referenced Doppler Optical Coherence Tomography” Optics Letters, vol. 27, No. 23, Dec. 1, 2002.Applicant
- International Search Report and Written Opinion dated Dec. 20, 2004 for PCT/US04/10152.Applicant
- Notification Concerning Transmittal of International Preliminary Report on Patentability dated Oct. 13, 2005 for PCT/US04/10152.Applicant
- International Search Report and Written Opinion dated Mar. 23, 2006 for PCT/US2005/042408.Applicant
- International Preliminary Report on Patentability dated Jun. 7, 2007 for PCT/US2005/042408.Applicant
- International Search Report and Written Opinion dated Feb. 28, 2007 for International Application No. PCT/US2006/038277.Applicant
- International Search Report and Written Opinion dated Jan. 30, 2009 for International Application No. PCT/US2008/081834.Applicant
- Fox, J.A. et al; “A New Galvanometric Scanner for Rapid tuning of C02 Lasers” New York, IEEE, US vol. Apr. 7, 1991.Applicant
- Motaghian Nezam, S.M. et al: “High-speed Wavelength-Swept Semiconductor laser using a Diffrection Grating and a Polygon Scanner in Littro Configuration” Optical Fiber Communication and the National Fiber Optic Engineers Conference Mar. 29, 2007.Applicant
- International Search Report and Written Opinion dated Feb. 2, 2009 for International Application No. PCT/US2008/071786.Applicant
- Bilenca A et al: “The Role of Amplitude and phase in Fluorescence Coherence Imaging: From Wide Filed to Nanometer Depth Profiling”, Optics IEEE, May 5, 2007.Applicant
- Inoue, Yusuke et al: “Varible Phase-Contrast Fluorescence Spectrometry for Fluorescently Strained Cells”, Applied Physics Letters, Sep. 18, 2006.Applicant
- Bernet, S et al: “Quantitative Imaging of Complex Samples by Spiral Phase Contrast Microscopy”, Optics Express, May 9, 2006.Applicant
- International Search Report and Written Opinion dated Jan. 15, 2009 for International Application No. PCT/US2008/074863.Applicant
- Office Action dated Feb. 17, 2009 for U.S. Appl. No. 11/211,483.Applicant
- Notice of Reasons for Rejection mailed Dec. 2, 2008 for Japanese patent application No. 2000-533782.Applicant
- International Search Report and Written Opinion dated Feb. 24, 2009 for PCT/US2008/076447.Applicant
- European Official Action dated Dec. 2, 2008 for EP 07718117.0.Applicant
- Barfuss et al (1989) “Modified Optical Frequency Domain Reflectometry with High spatial Resolution for Components of integrated optic Systems”, Journal of Lightwave Technology, IEEE vol. 7., No. 1.Applicant
- Yun et al., (2004) “Removing the Depth-Degeneracy in Optical Frequency Domain Imaging with Frequency Shifting”, Optics Express, vol. 12, No. 20.Applicant
- International Search Report and Written Opinion dated Jun. 10, 2009 for PCT/US08/075456.Applicant
- European Search Report issued May 5, 2009 for European Application No. 01991471.2.Applicant
- Motz, J.T. et al: “Spectral- and Frequency-Encoded Fluorescence Imaging” Optics Letters, OSA, Optical Society of America, Washington, DC, US, vol. 30, No. 20, Oct. 15, 2005, pp. 2760-2762.Applicant
- Japanese Notice of Reasons for Rejection dated Jul. 14, 2009 for Japanese Patent application No. 2006-503161.Applicant
- Office Action dated Aug. 18, 2009 for U.S. Appl. No. 12/277,178.Applicant
- Office Action dated Aug. 13, 2009 for U.S. Appl. No. 10/136,813.Applicant
- Office Action dated Aug. 6, 2009 for U.S. Appl. No. 11/624,455.Applicant
- Office Action dated May 15, 2009 for U.S. Appl. No. 11/537,123.Applicant
- Office Action dated Apr. 17, 2009 for U.S. Appl. No. 11/537,343.Applicant
- Office Action dated Apr. 15, 2009 for U.S. Appl. No. 12/205,775.Applicant
- Office Action dated Dec. 9, 2008 for U.S. Appl. No. 09/709,162.Applicant
- Office Action dated Dec. 23, 2008 for U.S. Appl. No. 11/780,261.Applicant
- Office Action dated Jan. 9, 2010 for U.S. Appl. No. 11/624,455.Applicant
- Office Action dated Feb. 18, 2009 for U.S. Appl. No. 11/285,301.Applicant
- Beddow et al, (May 2002) “Improved Performance Interferomater Designs for Optical Coherence Tomography”, IEEE Optical Fiber Sensors Conference, pp. 527-530.Applicant
- Yaqoob et al., (Jun. 2002) “High-Speed Wavelength-Multiplexed Fiber-Optic Sensors for Biomedicine,” Sensors Proceedings of the IEEE, pp. 325-330.Applicant
- Office Action dated Feb. 18, 2009 for U.S. Appl. No. 11/697,012.Applicant
- Zhang et al, (Sep. 2004), “Fourier Domain Functional Optical Coherence Tomography”, Saratov Fall Meeting 2004, pp. 8-14.Applicant
- Office Action dated Feb. 23, 2009 for U.S. Appl. No. 11/956,129.Applicant
- Office Action dated Mar. 16, 2009 for U.S. Appl. No. 11/621,694.Applicant
- Office Action dated Oct. 1, 2009 for U.S. Appl. No. 11/677,278.Applicant
- Office Action dated Oct. 6, 2009 for U.S. Appl. No. 12/015,642.Applicant
- Lin, Stollen et al., (1977) “A CW Tunable Near-infrared (1.085-1.175-um) Raman Oscillator,” Optics Letters, vol. 1, 96.Applicant
- Summons to attend Oral Proceedings dated Oct. 9, 2009 for European patent application No. 06813365.1.Applicant
- Office Action dated Dec. 15, 2009 for U.S. Appl. No. 11/549,397.Applicant
- R. Haggitt et al., “Barrett's Esophagus Correlation Between Mucin Histochemistry, Flow Cytometry, and Histological Diagnosis for Predicting Increased Cancer Risk,” Apr. 1988, American Journal of Pathology, vol. 131, No. 1, pp. 53-61.Applicant
- R.H. Hardwick et al., (1995) “c-erbB-2 Overexpression in the Dysplasia/Carcinoma Sequence of Barrett's Oesophagus,” Journal of Clinical Pathology, vol. 48, No. 2, pp. 129-132.Applicant
- W. Polkowski et al, (1998) Clinical Decision making in Barrett's Oesophagus can be supported by Computerized Immunoquantitation and Morphometry of Features Associated with Proliferation and Differentiation, Journal of pathology, vol. 184, pp. 161-168.Applicant
- J.R. Turner et al., MN Antigen Expression in Normal Preneoplastic, and Neoplastic Esophagus: A Clinicopathological Study of a New Cancer-Associated Biomarker,: Jun. 1997, Human Pathology, vol. 28, No. 6, pp. 740-744.Applicant
- D.J. Bowery et al., (1999) “Patterns of Gastritis in Patients with Gastro-Oesophageal Reflux Disease,”, Gut, vol. 45, pp. 798-803.Applicant
- O'Reich et al., (2000) “Expression of Oestrogen and Progesterone Receptors in Low-Grade Endometrial Stromal Sarcomas,”, British Journal of Cancer, vol. 82, No. 5, pp. 1030-1034.Applicant
- M.I. Canto et al., (1999) “Vital Staining and Barrett's Esophagus,” Gastrointestinal Endoscopy, vol. 49, No. 3, Part 2, pp. S12-S16.Applicant
- S. Jackle et al., (2000) “In Vivo Endoscopic Optical Coherence Tomography of the Human Gastrointestinal Tract—Toward Optical Biopsy,” Encoscopy, vol. 32, No. 10, pp. 743-749.Applicant
- E. Montgomery et al., “Reproducibility of the Diagnosis of Dysplasia in Barrett Esophagus: A Reaffirmation,” Apr. 2001, Human Pathology, vol. 32, No. 4, pp. 368-378.Applicant
- H. Geddert et al., “Expression of Cyclin B1 in the Metaplasia-Dysphasia-Carcinoma Sequence of Barrett Esophagus,” Jan. 2002, Cancer, vol. 94, No. 1, pp. 212-218.Applicant
- P. Pfau et al., (2003) “Criteria for the Diagnosis of Dysphasia by Endoscopic Optical Coherence Tomography,” Gastrointestinal Endoscopy, vol. 58, No. 2, pp. 196-2002.Applicant
- R. Kiesslich et al., (2004) “Confocal Laser Endoscopy for Diagnosing Intraepithelial Neoplasias and Colorectal Cancer in Vivo,” Gastroenterology, vol. 127, No. 3, pp. 706-713.Applicant
- X. Qi et al., (2004) “Computer Aided Diagnosis of Dysphasia in Barrett's Esophagus Using Endoscopic Optical Coherence Tomography,” SPIE, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. Proc. of Conference on., vol. 5316, pp. 33-40.Applicant
- Seltzer et al., (1991) “160 nm Continuous Tuning of a MQW Laser in an External Cavity Across the Entire 1.3 μm Communications Window,” Electronics Letters, vol. 27, pp. 95-96.Applicant
- Office Action dated Jan. 25, 2010 for U.S. Appl. No. 11/537,048.Applicant
- International Search Report dated Jan. 27, 2010 for PCT/US2009/050553.Applicant
- International Search Report dated Jan. 27, 2010 for PCT/US2009/047988.Applicant
- International Search Report dated Feb. 23, 2010 for U.S. Appl. No. 11/445,131.Applicant
- Office Action dated Mar. 18, 2010 of U.S. Appl. No. 11/844,454.Applicant
- Office Action dated Apr. 8, 2010 of U.S. Appl. No. 11/414,564.Applicant
- Japanese Office Action dated Apr. 13, 2010 for Japanese Patent application No. 2007-515029.Applicant
- International Search Report dated May 27, 2010 for PCT/US2009/063420.Applicant
- Office Action dated May 28, 2010 for U.S. Appl. No. 12/015,642.Applicant
- Office Action dated Jun. 2, 2010 for U.S. Appl. No. 12/112,205.Applicant
- Office Action dated Jul. 7, 2010 for U.S. Appl. No. 11/624,277.Applicant
- Montag Ethan D., “Parts of the Eye” online textbook for JIMG 774: Vision & Psycophysics, download on Jun. 23, 2010 from http://www.cis.rit.edu/people/faculty/montag/vandplite/pages/chap—8/ch8p3.html.Applicant
- Office Action dated Jul. 16, 2010 for U.S. Appl. No. 11/445,990.Applicant
- Office Action dated Jul. 20, 2010 for U.S. Appl. No. 11/625,135.Applicant
- Office Action dated Aug. 5, 2010 for U.S. Appl. No. 11/623,852.Applicant
- Chinese office action dated Aug. 4, 2010 for CN 200780005949.9.Applicant
- Chinese office action dated Aug. 4, 2010 for CN 200780016266.3.Applicant
- Zhang et al., “Full Range Polarization-Sensitive Fourier Domain Optical Coherence Tomography” Optics Express, Nov. 29, 2004, vol. 12, No. 24.Applicant
- Office Action dated Aug. 27, 2010 for U.S. Appl. No. 11/569,790.Applicant
- Office Action dated Aug. 31, 2010 for U.S. Appl. No. 11/677,278.Applicant
- Office Action dated Sep. 3, 2010 for U.S. Appl. No. 12/139,314.Applicant
- Yong Zhao et al: “Virtual Data Grid Middleware Services for Data-Intensive Science”, Concurrency and Computation: Practice and Experience, Wiley, London, GB, Jan. 1, 2000, pp. 1-7, pp. 1532-0626.Applicant
- Swan et al., “Toward Nanometer-Scale Resolution in Fluorescence Microscopy using Spectral Self-Inteference” IEEE Journal. Selected Topics in Quantum Electronics 9 (2) 2003, pp. 294-300.Applicant
- Moiseev et al., “Spectral Self-Interfence Fluorescence Microscopy”, J. Appl. Phys. 96 (9) 2004, pp. 5311-5315.Applicant
- Hendrik Verschueren, “Interference Reflection Microscopy in Cell Biology”, J. Cell Sci. 75, 1985, pp. 289-301.Applicant
- Park et al., “Diffraction Phase and Fluorescence Microscopy”, Opt. Expr. 14 (18) 2006, pp. 8263-8268.Applicant
- Swan et al. “High Resolution Spectral Self-Interference Fluorescence Microscopy”, Proc. SPIE 4621, 2002, pp. 77-85.Applicant
- Sanchez et al., “Near-Field Fluorscence Microscopy Based on Two-Photon Excvitation with Metal Tips”, Phys. Rev. Lett. 82 (20) 1999, pp. 4014-4017.Applicant
- Wojtkowski, Maciej, Ph.D. “Three-Dimensional Retinal Imaging with High-Speed Ultrahigh-Resolution Optical Coherence Tomography” Ophthalmology, Oct. 2005, 112(10): 1734-1746.Applicant
- Vaughan, J.M. et al., “Brillouin Scattering, Density and Elastic Properties of the Lens and Cornea of the Eye”, Nature, vol. 284, Apr. 3, 1980, pp. 489-491.Applicant
- Hess, S.T. et al. “Ultra-high Resolution Imaging by Fluorescence Photoactivation Localization Microscopy” Biophysical Journal vol. 91, Dec. 2006, 4258-4272.Applicant
- Fernandez-Suarez, M. et al., “Fluorescent Probes for Super-Resolution Imaging in Living Cells” Nature Reviews Molecular Cell Biology vol. 9, Dec. 2008.Applicant
- Extended European Search Report mailed Dec. 14, 2010 for EP 10182301.1.Applicant
- S. Hell et al., “Breaking the diffraction resolution limit by stimulated-emission—stimulated-emission-depletion fluorescence microscopy,” Optics Letters. 19:495 (1995) and Ground State Depletion (GSD).Applicant
- S. Hell et al. “Ground-State-Depletion fluorescence microscopy—a concept for breaking the diffraction resolution limit,” Applied Physics B. 60:780 (1994)) fluorescence microscopy, photo-activated localization microscopy (PALM).Applicant
- E. Betzig et al. “Imaging intracellular fluorescent proteins at nanometer resolution,” Science 313:1642 (2006), stochastic optical reconstruction microscopy (STORM).Applicant
- M. Rust et al. “Sub-diffraction-limited imaging by stochastic optical reconstruction microscopy (STORM),” Nature Methods 3:783 (2006), and structured illumination microscopy (SIM).Applicant
- B. Bailey et al. “Enhancement of Axial Resolution in Fluorescence Microscopy by Standing-Wave Excitation,” Nature 366:44 (1993).Applicant
- M. Gustafsson “Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy,” Journal of Microscopy 198:82 (2000).Applicant
- M. Gustafsson “Nonlinear structured illumination microscopy: Wide-field fluorescence imaging with theoretically unlimited resolution,” PNAS 102:13081 (2005)).Applicant
- R. Thompson et al. “Precise nanometer localization analysis for individual fluorescent probes,” Biophysical Journal 82:2775 (2002).Applicant
- K. Drabe et al. “Localization of Spontaneous Emission in front of a mirror,” Optics Communications 73:91 (1989).Applicant
- Swan et al. “Toward nanometer-scale resolution in fluorescence microscopy using spectral self-interference,” IEEE Quantum Electronics 9:294 (2003).Applicant
- C. Joo, et al. “Spectral Domain optical coherence phase and multiphoton microscopy,” Optics Letters 32:623 (2007).Applicant
- Virmani et al., “Lesions from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions,” Arterioscler. Thromb. Vase. Bio., 20:1262-75 (2000).Applicant
- Gonzalez, R.C. and Wintz, P., “Digital Image Processing” Addison-Wesley Publishing Company, Reading MA, 1987.Applicant
- V. Tuchin et al., “Speckle interferometry in the measurements ofbiotissues vibrations,” SPIE, 1647: 125 (1992).Applicant
- A.A. Bednov et al., “Investigation of Statistical Properties of Lymph Flow Dynamics Using Speckle-Microscopy,” SPIE, 2981: 181-90 (1997).Applicant
- Feng et al., “Mesocopic Conductors and Correlations in Laser Speckle Patters” Science, New Series, vol. 251, No. 4994, pp. 633-639 (Feb. 8, 1991).Applicant
- Lee et al., “The Unstable Atheroma,” Arteriosclerosis, Thrombosis & Vascular Biology, 17:1859-67 (1997).Applicant
- International Search report dated Apr. 29, 2011 for PCT/US2010/051715.Applicant
- International Search report dated Sep. 13, 2010 for PCT/US2010/023215.Applicant
- International Search Report dated Jul. 28, 2011 for PCT/US2010/059534.Applicant
- International Search report dated Nov. 18, 2011 for PCT/US2011/027450.Applicant
- International Search report dated Nov. 18, 2011 for PCT/US2011/027437.Applicant
- International Search report dated Nov. 22, 2011 for PCT/US2011/027421.Applicant