US 8,475,370 B2Grant

Method for measuring patient motion, activity level, and posture along with PTT-based blood pressure

Issue Date:2013-07-02

•16 Claims

•15 Drawing Sheets

Abstract

The invention provides a system and method for measuring vital signs (e.g. SYS, DIA, SpO2, heart rate, and respiratory rate) and motion (e.g. activity level, posture, degree of motion, and arm height) from a patient. The system features: (i) first and second sensors configured to independently generate time-dependent waveforms indicative of one or more contractile properties of the patient's heart; and (ii) at least three motion-detecting sensors positioned on the forearm, upper arm, and a body location other than the forearm or upper arm of the patient. Each motion-detecting sensor generates at least one time-dependent motion waveform indicative of motion of the location on the patient's body to which it is affixed. A processing component, typically worn on the patient's body and featuring a microprocessor, receives the time-dependent waveforms generated by the different sensors and processes them to determine: (i) a pulse transit time calculated using a time difference between features in two separate time-dependent waveforms, (ii) a blood pressure value calculated from the time difference, and (iii) a motion parameter calculated from at least one motion waveform.

Metadata

Assignee

Sotera Wireless, Inc.

Inventors

Devin McCombie
Marshal Dhillon
Matt Banet

Application Information

Application Number:US 12/469,127

Filing Date:2009-05-20

Priority Date:2009-05-20

Art Unit:3766

Classifications

IPC:

A61B5/00

Patent Drawings (15 sheets)

Description

CROSS REFERENCES TO RELATED APPLICATION

[0001] Not Applicable

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] Not Applicable

BACKGROUND OF THE INVENTION

[0003] 1. Field of the Invention

[0004] The present invention relates to medical devices for monitoring vital signs, e.g., arterial blood pressure.

[0005] 2. Description of the Related Art

[0006] Pulse transit time (PTT), defined as the transit time for a pressure pulse launched by a heartbeat in a patient's arterial system, has been shown in a number of studies to correlate to systolic (SYS), diastolic (DIA), and mean (MAP) blood pressure. In these studies, PTT is typically measured with a conventional vital signs monitor that includes separate modules to determine both an electrocardiogram (ECG) and pulse oximetry (SpO2). During a PTT measurement, multiple electrodes typically attach to a patient's chest to determine a time-dependent ECG component characterized by a sharp spike called the ‘QRS complex’. The QRS complex indicates an initial depolarization of ventricles within the heart and, informally, marks the beginning of the heartbeat and a pressure pulse that follows. SpO2 is typically measured with a bandage or clothespin-shaped sensor that attaches to a patient's finger, and includes optical systems operating in both the red and infrared spectral regions. A photodetector measures radiation emitted from the optical systems that transmits through the patient's finger. Other body sites, e.g., the ear, forehead, and nose, can also be used in place of the finger. During a measurement, a microprocessor analyses both red and infrared radiation detected by the photodetector to determine the patient's blood oxygen saturation level and a time-dependent waveform called a photoplethysmograph (‘PPG’). Time-dependent features of the PPG indicate both pulse rate and a volumetric absorbance change in an underlying artery caused by the propagating pressure pulse.

[0007] Typical PTT measurements determine the time separating a maximum point on the QRS complex (indicating the peak of ventricular depolarization) and a foot of the optical waveform (indicating the beginning the pressure pulse). PTT depends primarily on arterial compliance, the propagation distance of the pressure pulse (which is closely approximated by the patient's arm length), and blood pressure. To account for patient-dependent properties, such as arterial compliance, PTT-based measurements of blood pressure are typically ‘calibrated’ using a conventional blood pressure cuff. Typically during the calibration process the blood pressure cuff is applied to the patient, used to make one or more blood pressure measurements, and then left on the patient. Going forward, the calibration blood pressure measurements are used, along with a change in PTT, to determine the patient's blood pressure and blood pressure variability. PTT typically relates inversely to blood pressure, i.e., a decrease in PTT indicates an increase in blood pressure.

[0008] The PPG, like most signals detected with optical means, is strongly affected by motion of the patient. For example, if the pulse oximeter is placed on the patient's finger, then motion of the finger can influence both the blood flow and degree of ambient light detected by the oximeter's optical system. This, in turn, can add unwanted noise to the PPG.

[0009] A number of issued U.S. patents describe the relationship between PTT and blood pressure. For example, U.S. Pat. Nos. 5,316,008; 5,857,975; 5,865,755; and 5,649,543 each describe an apparatus that includes conventional sensors that measure an ECG and PPG, which are then processed to determine PTT. U.S. Pat. No. 5,964,701 describes a finger-ring sensor that includes an optical system for detecting a PPG, and an accelerometer for detecting motion.

SUMMARY OF THE INVENTION

[0010] This invention provides a body-worn vital sign monitor featuring a series of sensors that measure time-dependent PPG, ECG, motion (ACC), and pressure waveforms to continuously monitor a patient's vital signs, degree of motion, posture and activity level. Blood pressure, a vital sign that is particularly useful for characterizing a patient's condition, is typically calculated from a PTT value determined from the PPG and ECG waveforms. Once determined, blood pressure and other vital signs can be further processed, typically with a server within a hospital, to alert a medical professional if the patient begins to decompensate. Processing the combination of the patient's motion and vital sign information is particularly useful, as these components are integrally related: a patient that is walking, for example, may have an accelerated heart rate and is likely breathing; the system can thus be designed to not alarm on these parameters, even if they exceed predetermined, preprogrammed levels.

[0011] In one aspect, the above-described systems provide a body-worn vital sign monitor that features an optical sensor, typically worn on the patient's finger, which includes a light source that emits radiation and a photodetector that detects radiation after it irradiates a portion of the patient's body to generate a time-dependent PPG. The monitor also includes an electrical sensor featuring at least two electrodes that measure electrical signals from the patient's body, and an electrical circuit that receives the electrical signals and processes them to determine a time-dependent ECG. To determine the patient's motion, posture, and activity level, the monitor features at least three motion-detecting sensors, each configured to be worn on a different location on the patient's body and to generate at least one time-dependent ACC waveform. The electrical sensor and the three motion-detecting sensors are typically included in a cable system worn on the patient's arm. A processing component within the monitor connects to cable system to receive the ECG, PPG, and the at least one ACC waveform generated by each motion-detecting sensor. The processing component operates a first algorithm that processes the PPG and ECG to determine a time difference between a time-dependent feature in each waveform; a second algorithm that processes the time difference to determine a blood pressure value; and a third algorithm that collectively processes the ACC waveforms generated by each motion-detecting sensor to determine at least one ‘motion parameter’ (e.g. the patient's posture, activity level, arm height, and degree of motion). A wireless system within the monitor transmits the patient's blood pressure value and the motion parameter to a remote receiver.

[0012] In other embodiments, PTT can be calculated from time-dependent waveforms other than the ECG and PPG, and then processed to determine blood pressure. In general, PTT can be calculated by measuring a temporal separation between features in two or more time-dependent waveforms measured from the human body. For example, PTT can be calculated from two separate PPGs measured by different optical sensors disposed on the patient's fingers, wrist, arm, chest, or virtually any other location where an optical signal can be measured using a transmission or reflection-mode optical configuration. In other embodiments, PTT can be calculated using at least one time-dependent waveform measured with an acoustic sensor, typically disposed on the patient's chest. Or it can be calculated using at least one time-dependent waveform measured using a pressure sensor, typically disposed on the patient's bicep, wrist, or finger. The pressure sensor can include, for example, a pressure transducer, piezoelectric sensor, actuator, polymer material, or inflatable cuff.

[0013] In one aspect, the invention provides a system and method for measuring vital signs (e.g. SYS, DIA, SpO2, heart rate, and respiratory rate) and motion (e.g. activity level, posture, degree of motion, and arm height) from a patient. The system features: (i) first and second sensors configured to independently generate time-dependent waveforms indicative of one or more contractile properties of the patient's heart; and (ii) at least three motion-detecting sensors positioned on the forearm, upper arm, and a body location other than the forearm or upper arm of the patient. Each motion-detecting sensor generates at least one time-dependent motion waveform indicative of motion of the location on the patient's body to which it is affixed. A processing component, typically worn on the patient's body and featuring a microprocessor, receives the time-dependent waveforms generated by the different sensors and processes them to determine: (i) a pulse transit time calculated using a time difference between features in two separate time-dependent waveforms, (ii) a blood pressure value calculated from the time difference, and (iii) a motion parameter calculated from at least one motion waveform. A wireless communication system, also worn on the patient's body and connected to the processing component, transmits the blood pressure value and the motion parameter to a remote receiver.

[0014] The contractile property of the patient's heart, for example, can be a beat, expansion, contraction, or any time-dependent variation of the heart that launches both electrical signals and a bolus of blood in the patient. The time-dependent waveform that results from this process, for example, can be an ECG waveform measured from any vector on the patient, a PPG waveform, an acoustic waveform measured with a microphone, or a pressure waveform measured with a transducer. In general, these waveforms can be measured from any location on the patient.

[0015] In embodiments, the first sensor is an optical sensor featuring a source of electromagnetic radiation configured to irradiate tissue of the patient, and a detector configured to detect one or more properties of the electromagnetic radiation after it irradiates the tissue. This sensor can detect, for example, an optical waveform that is indicative of volumetric changes in the irradiated tissue caused by ventricular contraction of the patient's heart. More specifically, the optical waveform represents a time-dependent change in optical absorption of an underlying vessel resulting from the ejection of blood from the left ventricle. The second sensor can be a similar sensor, positioned on another portion of the patient's body, and configured to measure a similar, time-dependent waveform. In embodiments, the pulse transit time used to determine blood pressure is a time difference between a peak of a QRS complex of an ECG waveform and an inflection point in the optical waveform (corresponding, e.g., to a rising edge of the waveform). Alternatively, the transit time is determined from time-dependent features on two separate optical waveforms.

[0016] The remote receiver that receives information describing the patient's blood pressure values and motion is typically configured to generate an alarm condition based on the blood pressure value, wherein the alarm condition can be modified based on a motion parameter. For example, an alarm condition indicating a need for medical intervention can be modified (e.g., turned off) by a motion parameter indicating that the patient is ambulatory.

[0017] Typically each of the three motion-detecting sensors is an accelerometer. The motion-detecting sensor positioned on the forearm is typically worn on the wrist, proximate to the processing component. The motion-detecting sensor positioned on the upper arm is typically electrically connected to the processing component through a cable. And the third motion-detecting sensor is typically positioned on the chest, and is also electrically connected to the processing component through the same cable. When referring to the motion-detecting sensors, ‘forearm’, as used herein, means any portion of the arm below the elbow, e.g. the forearm, wrist, hand, and fingers. ‘Upper arm’ means any portion of the arm above and including the elbow, e.g. the bicep, shoulder, and armpit.

[0018] The motion waveform generated by the motion-detecting sensor on the upper arm is transmitted to the processing component through the cable as a first digital data stream. Similarly, the motion waveform generated by the motion-detecting sensor positioned at a body location other than the forearm or upper arm is transmitted to the processing component through the same cable as a second digital data stream, wherein the processing component can resolve the first and second digital data streams. One of the time-dependent waveforms is an ECG waveform that is transmitted to the processing component through the cable as a third digital data stream that is separately resolvable from each of the first and second digital data streams.

[0019] In embodiments, the cable features a terminal portion that includes: a connector configured for reversible attachment of one or more ECG electrodes; an ECG circuit that receives electrical signals from one or more ECG electrodes and process them to determine an ECG waveform; and an analog-to-digital converter that converts the ECG waveforms into the third digital data stream. The terminal portion can also include one of the motion-detecting sensors, and is typically positioned at a body location other than the forearm or upper arm of the patient. In embodiments, the terminal portion is attached to the patient's chest.

[0020] In another aspect, the invention features a cable system that measures physiologic signals and motion information from a patient. The cable system integrates with a first sensor configured to detect a first time-dependent physiological waveform indicative of one or more contractile properties of the patient's heart, and includes: (i) an electrical sensor featuring at least two electrodes connected to an electrical circuit that generates a time-dependent electrical waveform indicative of contractile properties of the patient's heart, and (ii) at least two motion-detecting sensors that each generate at least one time-dependent motion waveform. Both the cable and the first sensor connect to a processing component that performs functions similar to that described above. Collectively, these systems can measure a blood pressure based on PTT, as described above.

[0021] The cable features a transmission line connected to: (i) the electrical sensor configured to receive the time-dependent electrical waveform; and (ii) either one or two motion-detecting sensors configured to receive a time-dependent motion waveform. The motion-detecting sensors are typically worn on the patient's upper arm, lower arm, and chest, with these arm positions defined above. The cable additionally includes a terminal portion, similar to that described above, that features the electrical circuit that determines the time-dependent electrical waveform, at least one motion-detecting sensor that determines the time-dependent motion waveform, and at least one analog-to-digital converter that digitizes these two waveforms before they pass through the cable. As described above, these waveforms are digitized to form separate digital data streams that are separately resolvable by the processing component. The electrical circuit in the terminal portion connects to at least three electrodes, with each electrode configured to detect an electrical signal from the patient's body. The electrodes typically connect to single-wire cables that plug into the terminal portion, and are typically worn on the patient's chest in a conventional ‘Einthoven's Triangle’ configuration. In embodiments, the terminal portion is a removable component featuring an ECG circuit that, in its different configurations, supports three, five, and twelve-lead ECG systems.

[0022] In another aspect, the invention features a method for calibrating a PTT-based blood pressure measurement using changes in a patient's arm height. The system includes a first sensor (e.g. an optical sensor) that generates a first time-dependent waveform indicative of one or more contractile properties of the patient's heart; and an electrical sensor that generates a time-dependent electrical waveform indicative of one or more contractile properties of the patient's heart. At least two motion-detecting sensors positioned on separate locations on the patient's body (e.g. the upper and lower arms) generate time-dependent motion waveforms that can be processed to determine, e.g., arm height. A processing component, similar to that described above, processes the time-dependent waveforms to determine: (i) first and second arm positions calculated from one or more of the time-dependent motion waveforms; (ii) first and second time differences between features in the time-dependent waveforms acquired in, respectively, the first and second arm positions; (iii) first and second blood pressure values calculated, respectively, at the first and second arm positions; and (iv) a blood pressure factor calculated using the first blood pressure value and the first time difference, together with the second blood pressure value and the second time difference.

[0023] In embodiments, the processing component further features a display component that renders a graphic interface which instructs the patient to move their arm to the first arm position and then to the second arm position. The processing component can also include an audio component that provides comparable audible instructions. Alternatively, the processing component analyzes the time-dependent motion waveforms to automatically detect when the patient's arm is in the first and second positions. While in these positions it automatically determines the first and second time difference and the corresponding first and second blood pressure values, and finally uses this information to determine the blood pressure factor. Ideally information gathered from more than two arm positions is used to determine the blood pressure factor.

[0024] The blood pressure factor essentially represents a calibration for the PTT-based blood pressure measurement. Once it is determined, the processing component determines a third time difference from the two time-dependent waveforms, and determines a blood pressure value using this time difference and the blood pressure factor.

[0025] In embodiments, the system additionally includes a pneumatic system featuring an inflatable cuff, a pump, and a pressure sensor that, collectively, make an oscillometric blood pressure measurement. During a calibration measurement, the inflatable cuff attaches to the patient's arm and is inflated by the pump. The pressure sensor measures a time-dependent pressure waveform representing a pressure within the inflatable cuff. Pulsations in the patient's arm caused by their blood pressure are superimposed on the pressure waveform. This can be done while the cuff is inflating or deflating, with both these processes occurring at a rate of 7-10 mmHg to make an accurate blood pressure measurement. Once this measurement is complete, the processing component analyzes the time-dependent pressure waveform to calculate at least one cuff-based blood pressure value, which it then uses along with a time difference and the blood pressure factor to continuously determine the patient's blood pressure during future, cuff-free measurements.

[0026] In another aspect, the invention provides a method for monitoring a patient featuring the following steps: (i) detecting first and second time-dependent physiological waveform indicative of one or more contractile properties of the patient's heart with a first and second sensors configured to be worn on the patient's body; (ii) detecting sets of time-dependent motion waveforms with at least two motion-detecting sensors positioned on different locations on the patient's body; (iii) processing the first and second time-dependent physiological waveforms to determine at least one vital sign; (iv) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter; (v) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and (vi) estimating the patient's activity state based on the probability.

[0027] In embodiments, the method includes calculating a mathematical transform (e.g. a Fourier Transform) of at least one motion waveform to determine a frequency-dependent motion waveform (e.g. a power spectrum). The amplitude of at least one frequency component of the power spectrum can then be processed to determine the motion parameter. For example, a band of frequency components between 0-3 Hz typically indicates that the patient is walking, while a similar band between 0-10 Hz typically indicates that the patient is convulsing. A higher-frequency band between 0-15 Hz typically indicates that a patient is falling. In this last case, the time-dependent motion waveform typically includes a signature (e.g. a rapid change in value) that can be further processed to indicate falling. Typically this change represents at least a 50% change in the motion waveform's value within a time period of less than 2 seconds.

[0028] Additionally, the analysis can include measuring a time-dependent variation (e.g. a standard deviation or mathematical derivative) of least one motion waveform to determine the motion parameter. In other embodiments, the method includes determining the motion parameter by comparing a time-dependent motion waveform to a mathematical function using, e.g., a numerical fitting algorithm such as a linear least squares or Marquardt-Levenberg non-linear fitting algorithm.

[0029] In embodiments, the method further includes determining a ‘logit variable’ z, or a mathematical derivative thereof, wherein z is defined as:
z=b₀+b₁x₁+b₂x₂+ . . . +b_mx_m
and wherein b₀, b₁, b₂, and b_m, are predetermined constants related to motion, and at least one of x₀, x₁, x₂, and x_m, is a motion parameter determined from an amplitude of at least one frequency component of the power spectrum or from a time-dependent waveform. The method then processes the logit variable z with a mathematical function to determine the probability that the patient is undergoing a specific activity state. For example, z can be processed to generate a probability function P, or a mathematical derivative thereof, wherein P is defined as:

[0030]

P = \frac{1}{1 - \exp (- z)}

and indicates a probability of an activity state. The method can then compare P, or a mathematical derivative thereof, to a predetermined threshold value to estimate the patient's activity state.

[0031] In embodiments this method is used to estimate activity and posture states such as resting, moving, sitting, standing, walking, running, falling, lying down, and convulsing. In embodiments, the vital sign determined with this method is blood pressure calculated from a time difference (e.g. a PTT value) between features in the ECG and PPG waveforms, or alternatively using features between any combination of time-dependent ECG, PPG, acoustic, or pressure waveforms. This includes, for example, two PPG waveforms measured from different locations on the patient's body.

[0032] In another aspect the invention provides a method for monitoring vital signs and posture of a patient. A monitor, similar to that described above, measures vital signs from time-dependent waveforms (e.g. any combination of optical, electrical, acoustic, or pressure waveforms) and a patient's posture with at least one motion-detecting sensor positioned on the patient's torso (e.g., an accelerometer positioned on the patient's chest). The processing component analyzes at least a portion of a set of time-dependent motion waveforms generated by the motion-detecting sensor to determine a vector corresponding to motion of the patient's torso. It then compares the vector to a coordinate space representative of how the motion-detecting sensor is oriented on the patient to determine a posture parameter (e.g. standing upright, sitting, and lying down).

[0033] To determine the vector the method includes an algorithm or computation function that analyzes three time-dependent motion waveforms, each corresponding to a unique axis of the motion-detecting sensor. The motion waveforms can yield three positional vectors that define a coordinate space. In a preferred embodiment, for example, the first positional vector corresponds to a vertical axis, a second positional vector corresponds to a horizontal axis, and the third positional vector corresponds to a normal axis extending normal from the patient's chest. Typically the posture parameter is an angle, e.g. an angle between the vector and at least one of the three positional vectors. For example, the angle can be between the vector and a vector corresponding to a vertical axis. The patient's posture is estimated to be upright if the angle is less than a threshold value that is substantially equivalent to 45 degrees (e.g., 45 degrees+/−10 degrees); otherwise, the patient's posture is estimated to be lying down. If the patient is lying down, the method can analyze the angle between the vector and a vector corresponding to a normal axis extending normal from the patient's chest. In this case, the patient's posture is estimated to be supine if the angle is less than a threshold value substantially equivalent to 35 degrees (e.g., 35 degrees+/−10 degrees), and prone if the angle is greater than a threshold value substantially equivalent to 135 degrees (e.g., 135 degrees+/−10 degrees). Finally, if the patient is lying down, the method can analyze the angle between the vector and a vector corresponding to a horizontal axis. In this case, the patient is estimated to be lying on a first side if the angle is less than a threshold value substantially equivalent to 90 degrees (e.g., 90 degrees+/−10 degrees), and lying on an opposing side if the angle is greater than a threshold value substantially equivalent to 90 degrees (e.g., 90 degrees+/−10 degrees).

[0034] Blood pressure is determined continuously and non-invasively using a technique, based on PTT, which does not require any source for external calibration. This technique, referred to herein as the ‘composite technique’, is carried out with a body-worn vital sign monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. The composite technique is described in detail in the co-pending patent application entitled: VITAL SIGN MONITOR FOR MEASURING BLOOD PRESSURE USING OPTICAL, ELECTRICAL, AND PRESSURE WAVEFORMS (U.S. Ser. No. 12/138,194; filed Jun. 12, 2008), the contents of which are fully incorporated herein by reference.

[0035] Still other embodiments are found in the following detailed description of the invention, and in the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

[0036] FIG. 1 shows a schematic drawing of a body-worn vital sign monitor featuring three accelerometers for detecting motion, along with ECG, optical, and pneumatic systems for measuring vital signs;

[0037] FIG. 2 shows a graph of time-dependent waveforms (ECG, PPG, and ACC_1-9) generated by, respectively, the ECG system, the optical system, and the accelerometer system of FIG. 1;

[0038] FIGS. 3A and 3B show an image of the body-worn vital sign monitor of FIG. 1 attached to a patient with and without, respectively, a cuff-based pneumatic system used for an indexing measurement;

[0039] FIG. 4 shows an image of the wrist-worn transceiver featured in the body-worn vital sign monitor of FIGS. 3A and 3B;

[0040] FIG. 5 shows a schematic drawing of a coordinate system used to calibrate accelerometers used in the body-worn vital sign monitor of FIGS. 3A and 3B;

[0041] FIG. 6 shows a schematic drawing of the three accelerometers, attached to a patient's arm and connected to the body-worn vital sign monitor of FIGS. 3A, 3B, and 4;

[0042] FIG. 7 shows a schematic drawing of a coordinate system representing an accelerometer coordinate space superimposed on a patient's torso;

[0043] FIG. 8 shows the accelerometer coordinate space of FIG. 7 and a vector representing the direction and magnitude of gravity, along with angles separating the vector from each axis of the coordinate system;

[0044] FIG. 9A is a graph showing time-dependent motion waveforms corresponding to different posture states and measured with an accelerometer positioned on a patient's chest;

[0045] FIG. 9B is a graph showing posture states calculated using the time-dependent motion waveforms of FIG. 9A and a mathematical model for determining a patient's posture;

[0046] FIG. 10 is a graph of time-dependent waveforms indicating a patient's elbow height and corresponding PTT;

[0047] FIGS. 11A and 11C are graphs of time-dependent waveforms generated with an accelerometer that represent, respectively, a patient walking and convulsing;

[0048] FIGS. 11B and 11D are graphs of frequency-dependent waveforms representing the power spectra of the time-dependent waveforms shown, respectively, in FIGS. 11A and 11C;

[0049] FIG. 12 is a schematic drawing of a calculation used to determine a type of activity state exhibited by a patient;

[0050] FIGS. 13A and 13B are receiver operating characteristic (ROC) curves that show results from the calculation of FIG. 12 for, respectively, a patient that is walking and resting; and

[0051] FIG. 14 is a flow chart describing an algorithm that processes information from the body-worn vital sign monitor of FIGS. 3A, 3B, and 4 to continuously determine a patient's vital signs and motion.

DETAILED DESCRIPTION OF THE INVENTION

System Overview

[0052] FIG. 1 shows a schematic drawing of a body-worn vital sign monitor 10 according to the invention featuring a wrist-worn transceiver 12 that continuously determines vital signs (e.g. SYS, DIA, SpO2, heart rate, respiratory rate, and temperature) and motion (e.g. posture, arm height, activity level, and degree of motion) for, e.g., an ambulatory patient in a hospital. The transceiver 12 connects to three separate accelerometers 14a, 14b, 14c distributed along a patient's arm and torso and connected to a single cable. Each of these sensors measures three unique ACC waveforms, each corresponding to a separate axis (x, y, or z), which are digitized internally and sent to a computer processing unit (CPU) 22 within the transceiver 12 for processing. The transceiver 12 also connects to an ECG system 16 that measures an ECG waveform, an optical system 18 that measures a PPG waveform, and a pneumatic system 20 for making cuff-based ‘indexing’ blood pressure measurements according to the composite technique. Collectively, these systems 14a-c, 16, 18, and 20 continuously measure the patient's vital signs and motion.

[0053] The ECG 16 and pneumatic 20 systems are stand-alone systems that include a separate microprocessor and analog-to-digital converter. During a measurement, they connect to the transceiver 12 through connectors 28, 30 and supply digital inputs using a communication protocol that runs on a controller-area network (CAN) bus. The CAN bus is a serial interface, typically used in the automotive industry, which allows different electronic systems to effectively communicate with each other, even in the presence of electrically noisy environments. A third connector 32 also supports the CAN bus and is used for ancillary medical devices (e.g. a glucometer) that is either worn by the patient or present in their hospital room.

[0054] The optical system 18 features an LED and photodetector and, unlike the ECG 16 and pneumatic 20 systems, generates an analog electrical signal that connects through a cable 36 and connector 26 to the transceiver 12. As is described in detail below, the optical 18 and ECG 16 systems generate synchronized time-dependent waveforms that are processed with the composite technique to determine a PTT-based blood pressure along with motion information. The body-worn vital sign monitor 10 measures these parameters continuously and non-invasively characterize the hospitalized patient.

[0055] The first accelerometer 14a is surface-mounted on a printed circuited board within the transceiver 12, which is typically worn on the patient's wrist like a watch. The second 14b accelerometer is typically disposed on the upper portion of the patient's arm and attaches to a cable 40 that connects the ECG system 16 to the transceiver 12. The third accelerometer 14c is typically worn on the patient's chest proximal to the ECG system 16. The second 14b and third 14c accelerometers integrate with the ECG system 16 into a single cable 40, as is described in more detail below, which extends from the patient's wrist to their chest and supplies digitized signals over the CAN bus. In total, the cable 40 connects to the ECG system 16, two accelerometers 14b, 14c, and at least three ECG electrodes (shown in FIGS. 3A and 3B, and described in more detail below). The cable typically includes 5 separate wires bundled together with a single protective cladding: the wires supply power and ground to the ECG system 16 and accelerometers 14b, 14c, provide high signal and low signal transmission lines for data transmitted over the CAN protocol, and provide a grounded electrical shield for each of these four wires. It is held in place by the ECG electrodes, which are typically disposable and feature an adhesive backing, and a series of bandaid-like disposable adhesive strips. This simplifies application of the system and reduces the number of sensing components attached to the patient.

[0056] To determine posture, arm height, activity level, and degree of motion, the transceiver's CPU 22 processes signals from each accelerometer 14a-c with a series of algorithms, described in detail below. In total, the CPU can process nine unique, time-dependent signals (ACC_1-9) corresponding to the three axes measured by the three separate accelerometers. Specifically, the algorithms determine parameters such as the patient's posture (e.g., sitting, standing, walking, resting, convulsing, falling), the degree of motion, the specific orientation of the patient's arm and how this affects vital signs (particularly blood pressure), and whether or not time-dependent signals measured by the ECG 16, optical 18, or pneumatic 20 systems are corrupted by motion. Once this is complete, the transceiver 12 uses an internal wireless transmitter 24 to send information in a series of packets, as indicated by arrow 34, to a central nursing station within a hospital. The wireless transmitter 24 typically operates on a protocol based on 802.11 and communicates with an existing network within the hospital. This information alerts a medical professional, such as a nurse or doctor, if the patient begins to decompensate. A server connected to the hospital network typically generates this alarm/alert once it receives the patient's vital signs, motion parameters, ECG, PPG, and ACC waveforms, and information describing their posture, and compares these parameters to preprogrammed threshold values. As described in detail below, this information, particularly vital signs and motion parameters, is closely coupled together. Alarm conditions corresponding to mobile and stationary patients are typically different, as motion can corrupt the accuracy of vital signs (e.g., by adding noise), and induce changes in them (e.g., through acceleration of the patient's heart and respiratory rates).

[0057] FIG. 2 shows time-dependent ECG 50, PPG 52, and ACC_1-954 waveforms that the body-worn vital sign monitor continuously collects and analyzes to determine the patient's vital signs and motion. The ECG waveform 50, generated by the ECG system and three electrodes attached to the patient's chest, features a sharply peaked QRS complex 56. This complex 56 marks the peak of ventricular depolarization and informally indicates the beginning of each cardiac cycle. For a normal rhythm it occurs for each heartbeat. The optical system generates a PPG 52 using an infrared LED and matched photodetector incorporated into an optical sensor that attaches to the base of the patient's thumb. A pulsatile feature 58 in the PPG 52 follows the QRS complex 56, typically by about one to two hundred milliseconds, and indicates a volumetric expansion in arteries and capillaries disposed underneath the optical sensor. The temporal difference between the peak of the QRS complex 56 and the foot 60 of the pulsatile feature 58 in the PPG waveform is the PTT, which as described in detail below is used to determine blood pressure according to the composite technique.

[0058] Each accelerometer generates three time-dependent ACC waveforms 54 (ACC_1-9) that, collectively, indicate the patient's motion. Each waveform is digitized within the accelerometer using an internal analog-to-digital circuit. In general, the frequency and magnitude of change in the shape of the ACC waveform indicate the type of motion that the patient is undergoing. For example, a typical waveform 54 features a relatively time-invariant component 53 indicating a period of time when the patient is relatively still, and a time-variant component 62 when the patient's activity level increases. As described in detail below, a frequency-dependent analysis of these components yields the type and degree of patient motion. During operation, an algorithm running on the CPU within the wrist-worn transceiver operates an algorithm that performs this analysis so that the patient's activity level can be characterized in real time.

[0059] FIGS. 3A and 3B show how the body-worn system 10 described with respect to FIG. 1 attaches to a patient 70. These figures show two configurations of the system: FIG. 3A shows the system used during the indexing portion of the composite technique, and includes a pneumatic, cuff-based system 85, while FIG. 3B shows the system used for subsequent continuous monitoring of the patient featuring a non-invasive blood pressure (cNIBP) measurement. The indexing measurement typically takes about 60 seconds, and is typically performed once every 4 hours. Once the indexing measurement is complete the cuff-based system is typically removed from the patient. The remainder of the time the system 10 performs the cNIBP measurement.

[0060] The body-worn system 10 features a wrist-worn transceiver 72, described in more detail in FIG. 5, featuring a touch panel interface 73 that displays blood pressure values and other vital signs. A wrist strap 90 affixes the transceiver 72 to the patient's wrist like a conventional wristwatch. A cable 92 connects an optical sensor 94 that wraps around the base of the patient's thumb to the transceiver 72. During a measurement, the optical sensor 94 generates a time-dependent PPG, similar to the waveform 52 shown in FIG. 2, which is processed along with an ECG to measure blood pressure. PTT-based measurements made from the thumb yield excellent correlation to blood pressure measured with a femoral arterial line. As described in detail in the above-referenced patent application, this provides an accurate representation of blood pressure in the central regions of the patient's body.

[0061] To determine ACC waveforms, such as the time-dependent waveform 54 shown in FIG. 2, the body-worn vital sign monitor 10 features three separate accelerometers located at different portions on the patient's arm. The first accelerometer is surface-mounted on a circuit board in the wrist-worn transceiver 72 and measures signals associated with movement of the patient's wrist. The second accelerometer is included in a small bulkhead portion 96 included along the span of the cable 86. During a measurement, a small piece of disposable tape, similar in size to a conventional bandaid, affixes the bulkhead portion 96 to the patient's arm. In this way the bulkhead portion 96 serves two purposes: 1) it measures a time-dependent ACC waveform from the mid-portion of the patient's arm, thereby allowing their posture and arm height to be determined as described in detail below; and 2) it secures the cable 86 to the patient's arm to increase comfort and performance of the body-worn vital sign monitor 10.

[0062] The cuff-based module 85 features a pneumatic system 76 that includes a pump, valve, pressure fittings, pressure sensor, analog-to-digital converter, microcontroller, and rechargeable battery. During an indexing measurement, it inflates a disposable cuff 84 and performs two measurements according to the composite technique: 1) it performs an inflation-based measurement of oscillometry to determine values for SYS, DIA, and MAP; and 2) it determines a patient-specific relationship between PTT and MAP. These measurements are performed according to the composite technique, and are described in detail in the above-referenced patent application entitled: ‘VITAL SIGN MONITOR FOR MEASURING BLOOD PRESSURE USING OPTICAL, ELECTRICAL, AND PRESSURE WAVEFORMS’ (U.S. Ser. No. 12/138,194; filed Jun. 12, 2008), the contents of which have been previously incorporated herein by reference.

[0063] The cuff 84 within the cuff-based pneumatic system 85 is typically disposable and features an internal, airtight bladder that wraps around the patient's bicep to deliver a uniform pressure field. During the indexing measurement, pressure values are digitized by the internal analog-to-digital converter, and sent through a cable 86 according to the CAN protocol, along with SYS, DIA, and MAP blood pressures, to the wrist-worn transceiver 72 for processing as described above. Once the cuff-based measurement is complete, the cuff-based module 85 is removed from the patient's arm and the cable 86 is disconnected from the wrist-worn transceiver 72. cNIBP is then determined using PTT, as described in detail below.

[0064] To determine an ECG, similar to waveform 50 shown in FIG. 2, the body-worn vital sign monitor 10 features a small-scale, three-lead ECG circuit integrated directly into a bulkhead 74 that terminates an ECG cable 82. The ECG circuit features an integrated circuit that collects electrical signals from three chest-worn ECG electrodes 78a-c connected through cables 80a-c. The ECG electrodes 78a-c are typically disposed in a conventional ‘Einthoven's Triangle’ configuration which is a triangle-like orientation of the electrodes 78a-c on the patient's chest that features three unique ECG vectors. From these electrical signals the ECG circuit determines up to three ECG waveforms, which are digitized using an analog-to-digital converter mounted proximal to the ECG circuit, and sent through a cable 82 to the wrist-worn transceiver 72 according to the CAN protocol. There, the ECG is processed with the PPG to determine the patient's blood pressure. Heart rate and respiratory rate are determined directly from the ECG waveform using known algorithms, such as those described in the following reference, the contents of which are incorporated herein by reference: ‘ECG Beat Detection Using Filter Banks’, Afonso et al., IEEE Trans. Biomed Eng., 46:192-202 (1999). The cable bulkhead 74 also includes an accelerometer that measures motion associated with the patient's chest as described above.

[0065] There are several advantages of digitizing ECG and ACC waveforms prior to transmitting them through the cable 82. First, a single transmission line in the cable 82 can transmit multiple digital waveforms, each generated by different sensors. This includes multiple ECG waveforms (corresponding, e.g., to vectors associated with three, five, and twelve-lead ECG systems) from the ECG circuit mounted in the bulkhead 74, along with waveforms associated with the x, y, and z axes of accelerometers mounted in the bulkheads 75, 96. Limiting the transmission line to a single cable reduces the number of wires attached to the patient, thereby decreasing the weight and cable-related clutter of the body-worn monitor. Second, cable motion induced by an ambulatory patient can change the electrical properties (e.g. electrical impendence) of its internal wires. This, in turn, can add noise to an analog signal and ultimately the vital sign calculated from it. A digital signal, in contrast, is relatively immune to such motion-induced artifacts.

[0066] More sophisticated ECG circuits can plug into the wrist-worn transceiver to replace the three-lead system shown in FIGS. 3A and 3B. These ECG circuits can include, e.g., five and twelve leads.

[0067] FIG. 4 shows a close-up view of the wrist-worn transceiver 72. As described above, it attaches to the patient's wrist using a flexible strap 90 which threads through two D-ring openings in a plastic housing 106. The transceiver 72 features a touchpanel display 100 that renders a graphical user interface 73 which is altered depending on the viewer (typically the patient or a medical professional). Specifically, the transceiver 72 includes a small-scale infrared barcode scanner 102 that, during use, can scan a barcode worn on a badge of a medical professional. The barcode indicates to the transceiver's software that, for example, a nurse or doctor is viewing the user interface. In response, the user interface 73 displays vital sign data and other medical diagnostic information appropriate for medical professionals. Using this interface 73, the nurse or doctor, for example, can view the vital sign information, set alarm parameters, and enter information about the patient (e.g. their demographic information, medication, or medical condition). The nurse can press a button on the user interface 73 indicating that these operations are complete. At this point, the display 100 renders an interface that is more appropriate to the patient, e.g. it displays parameters similar to those from a conventional wristwatch, such as time of day and battery power.

[0068] As described above, the transceiver 72 features three CAN connectors 104a-c on the side of its upper portion, each which supports the CAN protocol and wiring schematics, and relays digitized data to the internal CPU. Digital signals that pass through the CAN connectors include a header that indicates the specific signal (e.g. ECG, ACC, or pressure waveform from the cuff-based module) and the sensor from which the signal originated. This allows the CPU to easily interpret signals that arrive through the CAN connectors 104a-c, and means that these connectors are not associated with a specific cable. Any cable connecting to the transceiver can be plugged into any connector 104a-c. As shown in FIG. 3A, the first connector 104a receives the cable 82 that transports a digitized ECG waveform determined from the ECG circuit and electrodes, and digitized ACC waveforms measured by accelerometers in the cable bulkhead 74 and the bulkhead portion 96 associated with the ECG cable 82.

[0069] The second CAN connector 104b shown in FIG. 4 receives the cable 86 that connects to the pneumatic cuff-based system 85 and used for the pressure-dependent indexing measurement. This connector is used to receive a time-dependent pressure waveform delivered by the pneumatic system 85 to the patient's arm, along with values for SYS, DIA, and MAP values determined during the indexing measurement. A user unplugs the cable 86 from the connector 104b once the indexing measurement is complete, and plugs it back in after approximately four hours for another indexing measurement.

[0070] The final CAN connector 104c can be used for an ancillary device, e.g. a glucometer, infusion pump, body-worn insulin pump, ventilator, or end-tidal CO₂delivery system. As described above, digital information generated by these systems will include a header that indicates their origin so that the CPU can process them accordingly.

[0071] The transceiver includes a speaker 101 that allows a medical professional to communicate with the patient using a voice over Internet protocol (VOIP). For example, using the speaker 101 the medical professional could query the patient from a central nursing station or mobile phone connected to a wireless, Internet-based network within the hospital. Or the medical professional could wear a separate transceiver similar to the shown in FIG. 4, and use this as a communication device. In this application, the transceiver 72 worn by the patient functions much like a conventional cellular telephone or ‘walkie talkie’: it can be used for voice communications with the medical professional and can additionally relay information describing the patient's vital signs and motion.

Algorithms for Determining Patient Motion, Posture, Arm Height, Activity Level and the Effect of these Properties on Blood Pressure

[0072] Described below is an algorithm for using the three accelerometers featured in the above-described body-worn vital sign monitor to calculate a patient's motion, posture, arm height, activity level. Each of these parameters affects both blood pressure and PTT, and thus inclusion of them in an algorithm can improve the accuracy of these measurements and the alarms and calibration procedures associated with them.

Calculating Arm Height

[0073] To calculate a patient's arm height it is necessary to build a mathematical model representing the geometric orientation of the patient's arm, as detected with signals from the three accelerometers. FIG. 5 shows a schematic image of a coordinate system 109 centered around a plane 110 used to build this model for determining patient motion and activity level, and arm height. Each of these parameters, as discussed in detail below, has an impact on the patient's vital signs, and particularly blood pressure.

[0074] The algorithm for estimating a patient's motion and activity level begins with a calculation to determine their arm height. This is done using signals from accelerometers attached to the patient's bicep (i.e., with reference to FIG. 3A, an accelerometer included in the bulkhead portion 96 of cable 86) and wrist (i.e. the accelerometer surface-mounted to the circuit board within the wrist-worn transceiver 72). The mathematical model used for this algorithm features a calibration procedure used to identify the alignment of an axis associated with a vector R_A, which extends along the patient's arm. Typically this is done by assuming the body-worn vital sign monitor is attached to the patient's arm in a consistent manner, i.e. that shown in FIGS. 3A and 3B, and by using preprogrammed constants stored in memory associated with the CPU. Alternatively this can be done by prompting the patient (using, e.g., the wrist-worn transceiver 72) to assume a known and consistent position with respect to gravity (e.g., hanging their arm down in a vertical configuration). The axis of their arm is determined by sampling a DC portion of time-dependent ACC waveforms along the x, y, and z axes associated with the two above-mentioned accelerometers (i.e. ACC_1-6; the resultant values have units of g's) during the calibration procedure, and storing these numerical values as a vector in memory accessible with the CPU within the wrist-worn transceiver.

[0075] The algorithm determines a gravitational vector R_GAat a later time by again sampling DC portions of ACC_1-6. Once this is complete, the algorithm determines the angle □_GAbetween the fixed arm vector R_Aand the gravitational vector R_GAby calculating a dot product of the two vectors. As the patient moves their arm, signals measured by the two accelerometers vary, and are analyzed to determine a change in the gravitational vector R_GAand, subsequently, a change in the angle □_GA. The angle □_GAcan then be combined with an assumed, approximate length of the patient's arm (typically 0.8 m) to determine its height relative to a proximal joint, e.g. the elbow.

[0076] FIG. 6 indicates how this model and approach can be extended to determine the relative heights of the upper 117 and lower 116 segments of a patient's arm 115. In this derivation, described below, i, j, k represent the vector directions of, respectively, the x, y, and z axes of the coordinate system 109 shown in FIG. 5. Three accelerometers 102a-c are disposed, respectively, on the patient's chest just above their armpit, near their bicep, and near their wrist; this is consistent with positioning within the body-worn vital sign monitor, as described in FIGS. 3A and 3B. The vector R_Bextending along the upper portion 117 of the patient's arm is defined in this coordinate system as:
{right arrow over (R)}_B=r_Bxî+r_Byĵ+r_Bz{circumflex over (k)} (1)
At any given time, the gravitational vector R_GBis determined from ACC waveforms (ACC_1-3) using signals from the accelerometer 102b located near the patient's bicep, and is represented by equation (2) below:
{right arrow over (R)}_GB[n]=y_Bx[n]î+y_By[n]ĵ+y_Bz[n]{circumflex over (k)} (2)
Specifically, the CPU in the wrist-worn transceiver receives digitized signals representing the DC portion (e.g. component 53 in FIG. 2) of the ACC_1-3signals measured with accelerometer 102b, as represented by equation (3) below, where the parameter n is the value (having units of g's) sampled directly from the DC portion of the ACC waveform:
y_Bx[n]=y_DC,Bicep,x[n]; y_By[n]=y_DC,Bicep,y[n]; y_Bz[n]=y_DC,Bicep,z[n] (3)
The cosine of the angle □_GBseparating the vector R_Band the gravitational vector R_GBis determined using equation (4):

[0077]

\begin{matrix} \cos (θ_{GB} [n]) = \frac{{\overset{⇀}{R}}_{GB} [n] \cdot {\overset{⇀}{R}}_{B}}{ {\overset{⇀}{R}}_{GB} [n]   {\overset{⇀}{R}}_{B} } & (4) \end{matrix}

The definition of the dot product of the two vectors R_Band R_GBis:
{right arrow over (R)}_GB[n]·{right arrow over (R)}_B=(y_Bx[n]×r_Bx)+(y_By[n]×r_By)+(y_Bz[n]×r_Bz) (5)
and the definitions of the norms or magnitude of the vectors R_Band R_GBare:
∥{right arrow over (R)}_GB[n]∥=√{square root over ((y_Bx[n])²+(y_By[n])²+(y_Bz[n])²)}{square root over ((y_Bx[n])²+(y_By[n])²+(y_Bz[n])²)}{square root over ((y_Bx[n])²+(y_By[n])²+(y_Bz[n])²)} (6)
and
∥{right arrow over (R)}_B∥=√{square root over ((r_Bx)²+(r_By)²+(r_Bz)²)}{square root over ((r_Bx)²+(r_By)²+(r_Bz)²)}{square root over ((r_Bx)²+(r_By)²+(r_Bz)²)} (7)
Using the norm values for these vectors and the angle □_GBseparating them, as defined in equation (4), the height of the patient's elbow relative to their shoulder joint, as characterized by the accelerometer on their chest (h_E), is determined using equation (8), where the length of the upper arm is estimated as L_B:
h_E[n]=−L_B×cos(θ_GB[n]) (8)
As is described in more detail below, equation (8) estimates the height of the patient's arm relative to their heart. And this, in turn, can be used to further improve the accuracy of PTT-based blood pressure measurements.

[0078] The height of the patient's wrist joint h_Wis calculated in a similar manner using DC components from the time-domain waveforms (ACC_4-6) collected from the accelerometer 102a mounted within the wrist-worn transceiver. Specifically, the wrist vector R_Wis given by equation (9):
{right arrow over (R)}_W=r_Wxî+r_Wyĵ+r_Wz{circumflex over (k)} (9)
and the corresponding gravitational vector R_GWis given by equation (10):
{right arrow over (R)}_GW[n]=y_Wx[n]î+y_Wy[n]ĵ+y_Wz[n]{circumflex over (k)} (10)
The specific values used in equation (10) are measured directly from the accelerometer 102a; they are represented as n and have units of g's, as defined below:
y_Wx[n]=y_DC,Wrist,x[n]; y_Wy[n]=y_DC,Wrist,y[n]; y_Wz[n]=y_DC,Wrist,z[n] (11)
The vectors R_Wand R_GWdescribed above are used to determine the cosine of the angle □_GWseparating them using equation (12):

[0079]

\begin{matrix} \cos (θ_{GW} [n]) = \frac{{\overset{⇀}{R}}_{GW} [n] \cdot {\overset{⇀}{R}}_{W}}{ {\overset{⇀}{R}}_{WB} [n]   {\overset{⇀}{R}}_{W} } & (12) \end{matrix}

The definition of the dot product between the vectors R_Wand R_GWis:
{right arrow over (R)}_GW[n]·{right arrow over (R)}_W=(y_Wx[n]×r_Wx)+(y_Wy[n]×r_Wy)+(y_Wz[n]×r_Wz) (13)
and the definitions of the norm or magnitude of both the vectors R_Wand R_GWare:
∥{right arrow over (R)}_Gw[n]∥=√{square root over ((y_Wx[n])²+(y_Wy[n])²+(y_Wz[n])²)}{square root over ((y_Wx[n])²+(y_Wy[n])²+(y_Wz[n])²)}{square root over ((y_Wx[n])²+(y_Wy[n])²+(y_Wz[n])²)} (14)
and
∥{right arrow over (R)}_W∥=√{square root over ((r_Wx)²+(r_Wy)²+(r_Wz)²)}{square root over ((r_Wx)²+(r_Wy)²+(r_Wz)²)}{square root over ((r_Wx)²+(r_Wy)²+(r_Wz)²)} (15)
The height of the patient's wrist h_wcan be calculated using the norm values described above in equations (14) and (15), the cosine value described in equation (12), and the height of the patient's elbow determined in equation (8):
h_W[n]=h_E[n]−L_W×cos(θ_Gw[n]) (16)
In summary, the algorithm can use digitized signals from the accelerometers mounted on the patient's bicep and wrist, along with equations (8) and (16), to accurately determine the patient's arm height and position. As described below, these parameters can then be used to correct the PTT and provide a blood pressure calibration, similar to the cuff-based indexing measurement described above, that can further improve the accuracy of this measurement.
Calculating the Influence of Arm Height on Blood Pressure

[0080] A patient's blood pressure, as measured near the brachial artery, will vary with their arm height due to hydrostatic forces and gravity. This relationship between arm height and blood pressure enables two measurements: 1) a blood pressure ‘correction factor’, determined from slight changes in the patient's arm height, can be calculated and used to improve accuracy of the base blood pressure measurement; and 2) the relationship between PTT and blood pressure can be determined (like it is currently done using the indexing measurement) by measuring PTT at different arm heights, and calculating the change in PTT corresponding to the resultant change in height-dependent blood pressure. Specifically, using equations (8) and (16) above, and (21) below, an algorithm can calculate a change in a patient's blood pressure (BP) simply by using data from two accelerometers disposed on the wrist and bicep. The BP can be used as the correction factor. Exact blood pressure values can be estimated directly from arm height using an initial blood pressure value (determined, e.g., using the cuff-based module during an initial indexing measurement), the relative change in arm height, and the correction factor. This measurement can be performed, for example, when the patient is first admitted to the hospital. PTT determined at different arm heights provides multiple data points, each corresponding to a unique pair of blood pressure values determined as described above. The change in PTT values (PTT) corresponds to changes in arm height.

[0081] From these data, the algorithm can calculate for each patient how blood pressure changes with PTT, i.e. BP/PTT. This relationship relates to features of the patient's cardiovascular system, and will evolve over time due to changes, e.g., in the patient's arterial tone and vascular compliance. Accuracy of the body-worn vital sign monitor's blood pressure measurement can therefore be improved by periodically calculating BP/PTT. This is best done by: 1) combining a cuff-based initial indexing measurement to set baseline values for SYS, DIA, and MAP, and then determining BP/PTT as described above; and 2) continually calculating BP/PTT by using the patient's natural motion, or alternatively using well-defined motions (e.g., raising and lower the arm to specific positions) as prompted at specific times by monitor's user interface.

[0082] Going forward, the body-worn vital sign monitor measures PTT, and can use this value and the relationship determined from the above-described calibration to convert this to blood pressure. All future indexing measurements can be performed on command (e.g., using audio or visual instructions delivered by the wrist-worn transceiver) using changes in arm height, or as the patient naturally raises and lowers their arm as they move about the hospital.

[0083] To determine the relationship between PTT, arm height, and blood pressure, the algorithm running on the wrist-worn transceiver is derived from a standard linear model shown in equation (17):

[0084]

\begin{matrix} PTT = (\frac{1}{m_{BP}}) \times P_{MAP} + \tilde{B} & (17) \end{matrix}

Assuming a constant velocity of the arterial pulse along an arterial pathway (e.g., the pathway extending from the heart, through the arm, to the base of the thumb):

[0085]

\begin{matrix} \frac{\partial (PWV)}{\partial r} = 0 & (18) \end{matrix}

the linear PTT model described in equation (17) becomes:

[0086]

\begin{matrix} \frac{\partial (PTT)}{\partial r} = (\frac{1}{L}) (\frac{1}{m_{BP}} \times MAP + \tilde{B}) & (19) \end{matrix}

Equation (19) can be solved using piecewise integration along the upper 117 and lower 116 segments of the arm to yield the following equation for height-dependent PTT:

[0087]

\begin{matrix} PTT = (\frac{1}{m_{BP}} \times MAP + B) - \frac{1}{m_{BP}} \times [\begin{matrix} (\frac{L_{1}}{L}) (\frac{ρ {Gh}_{E}}{2}) + \\ (\frac{L_{2}}{L}) (\frac{ρ G}{2} (h_{W} + h_{E})) \end{matrix}] & (20) \end{matrix}

From equation (20) it is possible to determine a relative pressure change P_relinduced in a cNIBP measurement using the height of the patient's wrist (h_W) and elbow (h_E):

[0088]

\begin{matrix} P_{rel} [n] = (\frac{L_{1}}{L}) (\frac{ρ {Gh}_{E} [n]}{2}) + (\frac{L_{2}}{L}) (\frac{ρ G}{2} (h_{W} [n] + h_{E} [n])) & (21) \end{matrix}

As described above, P_relcan be used to both calibrate the cNIBP measurement deployed by the body-worn vital sign monitor, or supply a height-dependent correction factor that reduces or eliminates the effect of posture and arm height on a PTT-based blood pressure measurement.

[0089] FIG. 10 shows actual experimental data that illustrate how PTT changes with arm height. Data for this experiment were collected as the subject periodically raised and lowered their arm using a body-worn vital sign monitor similar to that shown in FIGS. 3A and 3B. Such motion would occur, for example, if the patient was walking. As shown in FIG. 10, changes in the patient's elbow height are represented by time-dependent changes in the DC portion of an ACC waveform, indicated by trace 160. These data are measured directly from an accelerometer positioned near the patient's bicep, as described above. PTT is measured from the same arm using the PPG and ECG waveforms, and is indicated by trace 162. As the patient raises and lowers their arm their PTT rises and falls accordingly, albeit with some delay due to the reaction time of the patient's cardiovascular system.

Calculating a Patient's Posture

[0090] As described above, a patient's posture can influence how the above-described system generates alarms/alerts. The body-worn monitor can determine a patient's posture using time-dependent ACC waveforms continuously generated from the three patient-worn accelerometers, as shown in FIGS. 3A, B. In embodiments, the accelerometer worn on the patient's chest can be exclusively used to simplify this calculation. An algorithm operating on the wrist-worn transceiver extracts DC values from waveforms measured from this accelerometer and processes them with an algorithm described below to determine posture. Specifically, referring to FIG. 7, torso posture is determined for a patient 145 using angles determined between the measured gravitational vector and the axes of a torso coordinate space 146. The axes of this space 146 are defined in a three-dimensional Euclidean space where {right arrow over (R)}_CVis the vertical axis, {right arrow over (R)}_CHis the horizontal axis, and {right arrow over (R)}_CNis the normal axis. These axes must be identified relative to a ‘chest accelerometer coordinate space’ before the patient's posture can be determined.

[0091] The first step in this procedure is to identify alignment of {right arrow over (R)}_CVin the chest accelerometer i coordinate space. This can be determined in either of two approaches. In the first approach, {right arrow over (R)}_CVis assumed based on a typical alignment of the body-worn monitor relative to the patient. During manufacturing, these parameters are then preprogrammed into firmware operating on the wrist-worn transceiver. In this procedure it is assumed that accelerometers within the body-worn monitor are applied to each patient with essentially the same configuration. In the second approach, {right arrow over (R)}_CVis identified on a patient-specific basis. Here, an algorithm operating on the wrist-worn transceiver prompts the patient (using, e.g., video instruction operating on the display, or audio instructions transmitted through the speaker) to assume a known position with respect to gravity (e.g., standing up with arms pointed straight down). The algorithm then calculates {right arrow over (R)}_CVfrom DC values corresponding to the x, y, and z axes of the chest accelerometer while the patient is in this position. This case, however, still requires knowledge of which arm (left or right) the monitor is worn on, as the chest accelerometer coordinate space can be rotated by 180 degrees depending on this orientation. A medical professional applying the monitor can enter this information using the GUI, described above. This potential for dual-arm attachment requires a set of two pre-determined vertical and normal vectors which are interchangeable depending on the monitor's location. Instead of manually entering this information, the arm on which the monitor is worn can be easily determined following attachment using measured values from the chest accelerometer values, with the assumption that {right arrow over (R)}_CVis not orthogonal to the gravity vector.

[0092] The second step in the procedure is to identify the alignment of {right arrow over (R)}_CNin the chest accelerometer coordinate space. The monitor can determine this vector, similar to the way it determines {right arrow over (R)}_CV, with one of two approaches. In the first approach the monitor assumes a typical alignment of the chest-worn accelerometer on the patient. In the second approach, the alignment is identified by prompting the patient to assume a known position with respect to gravity. The monitor then calculates {right arrow over (R)}_CNfrom the DC values of the time-dependent ACC waveform.

[0093] The third step in the procedure is to identify the alignment of {right arrow over (R)}_CHin the chest accelerometer coordinate space. This vector is typically determined from the vector cross product of {right arrow over (R)}_CVand {right arrow over (R)}_CN, or it can be assumed based on the typical alignment of the accelerometer on the patient, as described above.

[0094] FIG. 8 shows the geometrical relationship between {right arrow over (R)}_CV140, {right arrow over (R)}_CN141, and {right arrow over (R)}_CH142 and a gravitational vector {right arrow over (R)}_G143 measured from a moving patient in a chest accelerometer coordinate space 139. The body-worn monitor continually determines a patient's posture from the angles separating these vectors. Specifically, the monitor continually calculates {right arrow over (R)}_G143 for the patient using DC values from the ACC waveform measured by the chest accelerometer. From this vector, the body-worn monitor identifies angles (θ_VG, θ_NG, and θ_HG) separating it from {right arrow over (R)}_CV140, {right arrow over (R)}_CN141, and {right arrow over (R)}_CH142. The body-worn monitor then compares these three angles to a set of predetermine posture thresholds to classify the patient's posture.

[0095] The derivation of this algorithm is as follows. Based on either an assumed orientation or a patient-specific calibration procedure described above, the alignment of {right arrow over (R)}_CVin the chest accelerometer coordinate space is given by:
{right arrow over (R)}_CV=r_CVxî+r_CVyĵ+r_CVz{circumflex over (k)} (22)
At any given moment, {right arrow over (R)}_Gis constructed from DC values of the ACC waveform from the chest accelerometer along the x, y, and z axes:
{right arrow over (R)}_G[n]=y_Cx[n]î+y_Cy[n]ĵ+y_Cz[n]{circumflex over (k)} (23)
Equation (24) shows specific components of the ACC waveform used for this calculation:
y_Cx[n]=y_DC,chest,x[n]; y_Cy[n]=y_DC,chest,y[n]; y_Cz[n]=y_DC,chest,z[n] (24)
The angle between {right arrow over (R)}_CVand {right arrow over (R)}_Gis given by equation (25):

[0096]

\begin{matrix} θ_{VG} [n] = \arccos (\frac{{\overset{⇀}{R}}_{G} [n] \cdot {\overset{⇀}{R}}_{CV}}{ {\overset{⇀}{R}}_{G} [n]   {\overset{⇀}{R}}_{CV} }) & (25) \end{matrix}

where the dot product of the two vectors is defined as:
{right arrow over (R)}_G[n]·{right arrow over (R)}_CV=(y_Cx[n]×r_CVx)+(y_Cy[n]×r_CVy)+(y_Cz[n]×r_CVz) (26)
The definition of the norms of {right arrow over (R)}_Gand {right arrow over (R)}_CVare given by equations (27) and (28):
∥{right arrow over (R)}[n]∥=√{square root over ((y_Cx[n])²+(y_Cy[n])²+(y_Cz[n])²)}{square root over ((y_Cx[n])²+(y_Cy[n])²+(y_Cz[n])²)}{square root over ((y_Cx[n])²+(y_Cy[n])²+(y_Cz[n])²)} (27)
∥{right arrow over (R)}_CV∥=√{square root over ((r_CVx)²+(r_CVy)²+(r_CVz)²)}{square root over ((r_CVx)²+(r_CVy)²+(r_CVz)²)}{square root over ((r_CVx)²+(r_CVy)²+(r_CVz)²)} (28)

[0097] As shown in equation (29), the monitor compares the vertical angle θ_VGto a threshold angle to determine whether the patient is vertical (i.e. standing upright) or lying down:
if θ_VG≦45° then Torso State=0, the patient is upright (29)
If the condition in equation (29) is met the patient is assumed to be upright, and their torso state, which is a numerical value equated to the patient's posture, is equal to 0. The torso state is processed by the body-worn monitor to indicate, e.g., a specific icon corresponding to this state. The patient is assumed to be lying down if the condition in equation (8) is not met, i.e. θ_VG>45 degrees. Their lying position is then determined from angles separating the two remaining vectors, as defined below.

[0098] The angle θ_NGbetween {right arrow over (R)}_CNand {right arrow over (R)}_Gdetermines if the patient is lying in the supine position (chest up), prone position (chest down), or on their side. Based on either an assumed orientation or a patient-specific calibration procedure, as described above, the alignment of {right arrow over (R)}_CNis given by equation (30), where i, j, k represent the unit vectors of the x, y, and z axes of the chest accelerometer coordinate space respectively:
{right arrow over (R)}_CN=r_CNxî+r_CNyĵ+r_CNz{circumflex over (k)} (30)
The angle between {right arrow over (R)}_CNand {right arrow over (R)}_Gdetermined from DC values extracted from the chest accelerometer ACC waveform is given by equation (31):

[0099]

\begin{matrix} θ_{NG} [n] = \arccos (\frac{{\overset{⇀}{R}}_{G} [n] \cdot {\overset{⇀}{R}}_{CN}}{ {\overset{⇀}{R}}_{G} [n]   {\overset{⇀}{R}}_{CN} }) & (31) \end{matrix}

The body-worn monitor determines the normal angle θ_NGand then compares it to a set of predetermined threshold angles to determine which position the patient is lying in, as shown in equation (32):
if θ_NG≦35° then Torso State=1, the patient is supine
if θ_NG≧135° then Torso State=2, the patient is prone (32)
If the conditions in equation (32) are not met then the patient is assumed to be lying on their side. Whether they are lying on their right or left side is determined from the angle calculated between the horizontal torso vector and measured gravitational vectors, as described above.

[0100] The alignment of {right arrow over (R)}_CHis determined using either an assumed orientation, or from the vector cross-product of {right arrow over (R)}_CVand {right arrow over (R)}_CNas given by equation (33), where i, j, k represent the unit vectors of the x, y, and z axes of the accelerometer coordinate space respectively. Note that the orientation of the calculated vector is dependent on the order of the vectors in the operation. The order below defines the horizontal axis as positive towards the right side of the patient's body.
{right arrow over (R)}_CH=r_CVxî+r_CVyĵ+r_CVz{circumflex over (k)}={right arrow over (R)}_CV×{right arrow over (R)}_CN (33)
The angle θ_HGbetween {right arrow over (R)}_CHand {right arrow over (R)}_Gis determined using equation (34):

[0101]

\begin{matrix} θ_{HG} [n] = \arccos (\frac{{\overset{⇀}{R}}_{G} [n] \cdot {\overset{⇀}{R}}_{CH}}{ {\overset{⇀}{R}}_{G} [n]   {\overset{⇀}{R}}_{CH} }) & (34) \end{matrix}

The monitor compares this angle to a set of predetermined threshold angles to determine if the patient is lying on their right or left side, as given by equation (35):
if θ_HG≧90° then Torso State=3, the patient is on their right side
if θ_NG<90° then Torso State=4, the patient is on their left side (35)
Table 1 describes each of the above-described postures, along with a corresponding numerical torso state used to render, e.g., a particular icon:

[0102]

TABLE 1

postures and their corresponding torso states
	Posture	Torso State

	Upright	0
	supine: lying on back	1
	prone: lying on chest	2
	lying on right side	3
	lying on left side	4
	undetermined posture	5

[0103] FIGS. 9A and 9B show, respectively, graphs of time-dependent ACC waveforms 150 measured along the x, y, and z-axes, and the torso states (i.e. postures) 151 determined from these waveforms for a moving patient. As the patient moves, the DC values of the ACC waveforms measured by the chest accelerometer vary accordingly, as shown by the graph 150 in FIG. 9A. The body-worn monitor processes these values as described above to continually determine {right arrow over (R)}_Gand the various quantized torso states for the patient, as shown in the graph 151 in FIG. 9B. The torso states yield the patient's posture as defined in Table 1. For this study the patient rapidly alternated between standing, lying on their back, chest, right side, and left side within about 150 seconds. As described above, different alarm/alert conditions (e.g. threshold values) for vital signs can be assigned to each of these postures, or the specific posture itself may result in an alarm/alert. Additionally, the time-dependent properties of the graph 151 can be analyzed (e.g. changes in the torso states can be counted) to determine, for example, how often the patient moves in their hospital bed. This number can then be equated to various metrics, such as a ‘bed sore index’ indicating a patient that is so stationary in their bed that lesions may result. Such a state could then be used to trigger an alarm/alert to the supervising medical professional.

Calculating a Patient's Activity

[0104] An algorithm can process information generated by the accelerometers described above to determine a patient's specific activity (e.g., walking, resting, convulsing), which is then used to reduce the occurrence of false alarms. This classification is done using a ‘logistic regression model classifier’, which is a type of classifier that processes continuous data values and maps them to an output that lies on the interval between 0 and 1. A classification ‘threshold’ is then set as a fractional value within this interval. If the model output is greater than or equal to this threshold, the classification is declared ‘true’, and a specific activity state can be assumed for the patient. If the model output falls below the threshold, then the specific activity is assumed not to take place.

[0105] This type of classification model offers several advantages. First, it provides the ability to combine multiple input variables into a single model, and map them to a single probability ranging between 0 and 1. Second, the threshold that allows the maximum true positive outcomes and the minimum false positive outcomes can be easily determined from a ROC curve, which in turn can be determined using empirical experimentation and data. Third, this technique requires minimal computation.

[0106] The formula for the logistic regression model is given by equation (36) and is used to determine the outcome, P, for a set of buffered data:

[0107]

\begin{matrix} P = \frac{1}{1 - \exp (- z)} & (36) \end{matrix}

[0108] The logit variable z is defined in terms of a series of predictors (x_i), each affected by a specific type of activity, and determined by the three accelerometers worn by the patient, as shown in equation (37):
z=b₀+b₁x₁+b₂x₂+ . . . +b_mx_m (37)
In this model, the regression coefficients (b_i, i=0, 1, . . . , m) and the threshold (P_th) used in the patient motion classifier and signal corruption classifiers are determined empirically from data collected on actual subjects. The classifier results in a positive outcome as given in equation (38) if the logistic model output, P, is greater than the predetermined threshold, P_th:
If P≧P_ththen Classifier State=1 (38)

[0109] FIGS. 11A-D indicate how the above-described predictors can be processed to determine a patient's specific activity level. As shown in FIG. 11A, a time-dependent ACC waveform 130 measured with an accelerometer from a walking patient typically features DC portions before 129a and after 129b the patient finishes walking, and a periodic AC portion 131 measured during walking. A Fourier Transform of the waveform, as shown by the frequency-dependent waveform 132 in FIG. 11B, yields a power spectrum featuring a well-defined frequency component 133 (typically near 1-3 Hz, with an average of about 1.5 Hz), corresponding to the frequency of the patient's stride. FIGS. 11C and 11D indicate another activity state. Here, the patient is convulsing, and the time-dependent ACC waveform 134 shown in FIG. 11C features two oscillating ‘bursts’ 135a, 135b separated by periods of inactivity. A Fourier Transform of this waveform, as shown by the power spectrum 136 in FIG. 11D, indicates two frequency components 137a, 137b, both having relatively large values (typically 4-8 Hz, depending on the type of convulsion) compared to that shown in FIG. 11B. These frequency components 137a, 137b correspond to the frequency-dependent content of the oscillating bursts 135a, 135b.

[0110] FIG. 12 shows a block diagram 180 indicating the mathematical model used to determine the above-described logistic regression model classifier. In this model, the series of predictor variables (x_i) are determined from statistical properties of the time-dependent ACC waveforms, along with specific frequency components contained in the power spectra of these waveforms. The frequency components are determined in a low-frequency region (0-20 Hz) of these spectra that corresponds to human motion. Specifically, the predictor variables can be categorized by first taking a power spectrum of a time-dependent ACC waveform generated by an accelerometer, normalizing it, and then separating the fractional power into frequency bands according to Table 2, below:

[0111]

TABLE 2

predictor variables and their relationship
to the accelerometer signal
	predictor
	variable	Description

	x₁	normalized power of the AC component
		of the time-dependent accelerometer
		signal
	x₂	average arm angle measured while time-
		dependent accelerometer signal is
		collected
	x₃	standard deviation of the arm angle while
		time-dependent accelerometer signal is
		collected
	x₄	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 0.5-1.0 Hz
	x₅	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 1.0-2.0 Hz
	x₆	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 2.0-3.0 Hz
	x₇	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 3.0-4.0 Hz
	x₈	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 4.0-5.0 Hz
	x₉	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 5.0-6.0 Hz
	x₁₀	fractional power of the AC component of
		the frequency-dependent accelerometer
		signal between 6.0-7.0 Hz

The predictor variables described in Table 2 are typically determined from ACC signals generated by accelerometers deployed in locations that are most affected by patient motion. Such accelerometers are typically mounted directly on the wrist-worn transceiver, and on the bulkhead connector attached to the patient's arm. The normalized signal power (x₁) for the AC components (y_w,i, i=x, y, z) calculated from the ACC is shown in equation (39), where F_sdenotes the signal sampling frequency, N is the size of the data buffer, and x_normis a predetermined power value:

[0112]

\begin{matrix} x_{1} = \frac{1}{x_{norm}} (\frac{F_{S}}{N}) \sum_{n = 1}^{N} [{(y_{W, x} [n])}^{2} + {(y_{W, y} [n])}^{2} + {(y_{W, z} [n])}^{2}] & (39) \end{matrix}

The average arm angle predictor value (x₂) was determined using equation (40):

[0113]

\begin{matrix} x_{2} = (\frac{1}{N}) \sum_{n = 1}^{N} \cos (θ_{GW} [n]) & (40) \end{matrix}

Note that, for this predictor value, it is unnecessary to explicitly determine the angle □_GWusing an arccosine function, and the readily available cosine value calculated in equation (12) acts as a surrogate parameter indicating the mean arm angle. The predictor value indicating the standard deviation of the arm angle (x₃) was determined using equation (41) using the same assumptions for the angle □_GWas described above:

[0114]

\begin{matrix} x_{3} = \sqrt{(\frac{1}{N}) \sum_{n = 1}^{N} {(\cos (θ_{GW} [n]) - x_{2})}^{2}} & (41) \end{matrix}

[0115] The remaining predictor variables (x₄-x₁₀) are determined from the frequency content of the patient's motion, determined from the power spectrum of the time-dependent accelerometer signals, as indicated in FIGS. 11B and 11D. To simplify implementation of this methodology, it is typically only necessary to process a single channel of the ACC waveform. Typically, the single channel that is most affected by patient motion is y_W, which represents motion along the long axis of the patient's lower arm, determined from the accelerometer mounted directly in the wrist-worn transceiver. Determining the power requires taking an N-point Fast Fourier Transform (FFT) of the accelerometer data (X_W[m]); a sample FFT data point is indicated by equation (42):
X_W[m]=a_m+ib_m (42)
Once the FFT is determined from the entire time-domain ACC waveform, the fractional power in the designated frequency band is given by equation (43), which is based on Parseval's theorem. The term mStart refers to the FFT coefficient index at the start of the frequency band of interest, and the term mEnd refers to the FFT coefficient index at the end of the frequency band of interest:

[0116]

\begin{matrix} x_{k} = (\frac{1}{P_{T}}) \sum_{m = mStart}^{mEnd} (a_{m} + {ib}_{m}) (a_{m} - {ib}_{m}) & (43) \end{matrix}

Finally, the formula for the total signal power, P_T, is given in equation (44):

[0117]

\begin{matrix} P_{T} = \sum_{m = 0}^{N / 2} (a_{m} + {ib}_{m}) (a_{m} - {ib}_{m}) & (44) \end{matrix}

[0118] As described above, to accurately estimate a patient's activity level, predictor values x₁-x₁₀defined above are measured from a variety of subjects selected from a range of demographic criteria (e.g., age, gender, height, weight), and then processed using predetermined regression coefficients (b_j) to calculate a logit variable (defined in equation (37)) and the corresponding probability outcome (defined in equation (36)). A threshold value is then determined empirically from an ROC curve. The classification is declared true if the model output is greater than or equal to the threshold value. During an actual measurement, an accelerometer signal is measured and then processed as described above to determine the predictor values. These parameters are used to determine the logit and corresponding probability, which is then compared to a threshold value to estimate the patient's activity level.

[0119] FIGS. 13A,B show actual ROC curves, determined using accelerometers placed on the upper and lower arms of a collection of patients. An ideal ROC curve indicates a high true positive rate (shown on the y-axis) and a low false positive rate (shown on the x-axis), and thus has a shape closely representing a 90 degree angle. From such a curve a relatively high threshold can be easily determined and used as described above to determine a patient's activity level. Ultimately this results in a measurement that yields a high percentage of ‘true positives’, and a low percentage of ‘false positives’. FIG. 13A shows, for example, a ROC curve generated from the patients' upper 192 and lower 190 arms during walking. Data points on the curves 190, 192 were generated with accelerometers and processed with algorithms as described above. The distribution of these data indicates that this approach yields a high selectivity for determining whether or not a patient is walking.

[0120] FIG. 13B shows data measured during resting. The ACC waveforms measured for this activity state feature fewer well-defined frequency components compared to those measured for FIG. 13A, mostly because the act of ‘resting’ is not as well defined as that of ‘walking’. That is why the ROC curves measured from the upper 194 and lower 196 arms have less of an idealized shape. Still, from these data threshold values can be determined that can be used for future measurements to accurately characterize whether or not the patient is resting.

[0121] ROC curves similar to those shown in FIGS. 13A,B can be generated empirically from a set of patients undergoing a variety of different activity states. These states include, among others, falling, convulsing, running, eating, and undergoing a bowel movement. A threshold value for each activity state is determined once the ROC curve is generated, and going forward this information can be incorporated in an algorithm for estimating the patient's activity. Such an algorithm, e.g., can be uploaded wirelessly to the wrist-worn transceiver.

[0122] FIG. 14 is a flow chart 200 showing the various algorithms described above, along with other supporting algorithms described in co-pending patent application, the contents of which are fully incorporated herein by reference.

[0123] The initiation phase of the algorithm begins with collection of time-dependent PPG, ECG, ACC, and pressure waveforms using analog and digital circuitry within the body-worn vital sign monitor described above (step 201). An optical sensor attached to the patient's thumb measures PPG waveforms, while an ECG circuit attached to three electrodes on the patient's chest measures ECG waveforms. Once collected, these waveforms are digitally filtered according to step 202 using standard frequency-domain techniques to remove any out-of-band noise. The pressure waveform, generated during an indexing measurement during step 204 using a pneumatic system and cuff wrapped around the patient's bicep, is measured during inflation and processed using oscillometry, as described in the above-referenced patient application entitled: ‘VITAL SIGN MONITOR FOR MEASURING BLOOD PRESSURE USING OPTICAL, ELECTRICAL, AND PRESSURE WAVEFORMS’ (U.S. Ser. No. 12/138,194; filed Jun. 12, 2008), the contents of which have been previously incorporated herein by reference. This yields an indirect measurement of SYS, DIA, and MAP values. Alternatively, SYS can be determined directly by processing the PPG in the presence of applied pressure according to step 206 (as described in patent application referenced immediately above). PTT is measured as a function of applied pressure during the indexing measurement, and is processed during step 208 according to determine a personal, patient-specific slope (as described in patent application referenced immediately above). This slope, along with blood pressure values determined with oscillometry during the indexing measurement, is used along with PTT values measured from a temporal separation between the ECG and PPG to determine cNIBP according to step 220 (as described in patent application referenced immediately above).

[0124] Motion, as described in detail above, can complicate measurement of the above-described parameters, and is determined by processing time-dependent ACC signals from multiple accelerometers attached to the patient and connected to the body-worn vital sign monitor. These signals are processed according to steps 210, 212, and 214, as described in detail above, to determine the degree of motion-based signal corruption, and according to step 218 to determine posture, arm height, and activity level. If motion is determined to be present, cNIBP can be estimated according to step 216 using a read-through technique.

[0125] SpO2 is measured according to step 222 with the body-worn vital sign monitor using an integrated reference hardware design, algorithm, and code base provided by OSI of Hawthorne, Calif. Conventional algorithms for SpO2 are optimized for measurements made at the tip of the patient's index finger. However, since optical measurements with the body-worn vital sign monitor described above are typically made from the base of the patient's thumb, a modified set of calibration parameters need to be experimentally determined for this location using informal clinical trials.

[0126] The above-described measurements for PTT-based cNIBP are performed according to step 220 by collecting data for 20-second periods, and then processing these data with a variety of statistical averaging techniques. Pressure-dependent indexing measurements according to steps 204 and 206 are performed every 4 hours. In the algorithm described above, a technique for rolling averages can be deployed, allowing values for cNIBP (step 220), HR and TEMP (step 226), RR (step 224), and SpO2 (step 222) to be displayed every second. The interval for pressure-dependent indexing measurements may be extended past four hours.

[0127] In addition to those methods described above, a number of additional methods can be used to calculate blood pressure from the optical and electrical waveforms. These are described in the following co-pending patent applications, the contents of which are incorporated herein by reference: 1) CUFFLESS BLOOD-PRESSURE MONITOR AND ACCOMPANYING WIRELESS, INTERNET-BASED SYSTEM (U.S. Ser. No. 10/709,015; filed Apr. 7, 2004); 2) CUFFLESS SYSTEM FOR MEASURING BLOOD PRESSURE (U.S. Ser. No. 10/709,014; filed Apr. 7, 2004); 3) CUFFLESS BLOOD PRESSURE MONITOR AND ACCOMPANYING WEB SERVICES INTERFACE (U.S. Ser. No. 10/810,237; filed Mar. 26, 2004); 4) CUFFLESS BLOOD PRESSURE MONITOR AND ACCOMPANYING WIRELESS MOBILE DEVICE (U.S. Ser. No. 10/967,511; filed Oct. 18, 2004); 5) BLOOD PRESSURE MONITORING DEVICE FEATURING A CALIBRATION-BASED ANALYSIS (U.S. Ser. No. 10/967,610; filed Oct. 18, 2004); 6) PERSONAL COMPUTER-BASED VITAL SIGN MONITOR (U.S. Ser. No. 10/906,342; filed Feb. 15, 2005); 7) PATCH SENSOR FOR MEASURING BLOOD PRESSURE WITHOUT A CUFF (U.S. Ser. No. 10/906,315; filed Feb. 14, 2005); 8) PATCH SENSOR FOR MEASURING VITAL SIGNS (U.S. Ser. No. 11/160,957; filed Jul. 18, 2005); 9) WIRELESS, INTERNET-BASED SYSTEM FOR MEASURING VITAL SIGNS FROM A PLURALITY OF PATIENTS IN A HOSPITAL OR MEDICAL CLINIC (U.S. Ser. No. 11/162,719; filed Sep. 9, 2005); 10) HAND-HELD MONITOR FOR MEASURING VITAL SIGNS (U.S. Ser. No. 11/162,742; filed Sep. 21, 2005); 11) CHEST STRAP FOR MEASURING VITAL SIGNS (U.S. Ser. No. 11/306,243; filed Dec. 20, 2005); 12) SYSTEM FOR MEASURING VITAL SIGNS USING AN OPTICAL MODULE FEATURING A GREEN LIGHT SOURCE (U.S. Ser. No. 11/307,375; filed Feb. 3, 2006); 13) BILATERAL DEVICE, SYSTEM AND METHOD FOR MONITORING VITAL SIGNS (U.S. Ser. No. 11/420,281; filed May 25, 2006); 14) SYSTEM FOR MEASURING VITAL SIGNS USING BILATERAL PULSE TRANSIT TIME (U.S. Ser. No. 11/420,652; filed May 26, 2006); 15) BLOOD PRESSURE MONITOR (U.S. Ser. No. 11/530,076; filed Sep. 8, 2006); 16) TWO-PART PATCH SENSOR FOR MONITORING VITAL SIGNS (U.S. Ser. No. 11/558,538; filed Nov. 10, 2006); and, 17) MONITOR FOR MEASURING VITAL SIGNS AND RENDERING VIDEO IMAGES (U.S. Ser. No. 11/682,177; filed Mar. 5, 2007).

[0128] Other embodiments are also within the scope of the invention. For example, other techniques, such as conventional oscillometry measured during deflation, can be used to determine SYS for the above-described algorithms. In another embodiment, ‘vascular transit time’ (VTT) measured from two PPG waveforms can be used in place of PTT, as described above.

[0129] Still other embodiments are within the scope of the following claims.

Claims

What is claimed is:

1. A method for monitoring a patient, comprising the following steps:

(a) detecting a first time-dependent physiological waveform indicative of one or more contractile properties of the patient's heart with a first sensor comprising a first detector configured to be worn on the patient's body;

(b) detecting a second time-dependent physiological waveform indicative of one or more contractile properties of the patient's heart with a second sensor comprising a second detector configured to be worn on the patient's body;

(c) detecting sets of time-dependent motion waveforms with at least two motion-detecting sensors positioned on different locations on the patient's body, wherein each motion-detecting sensor detects a set of motion waveforms indicative of motion of the location on the patient's body to which the motion-detecting sensor is affixed;

(d) processing the first and second time-dependent physiological waveforms to determine at least one vital sign from the patient;

(e) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter;

(f) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and

(g) estimating the patient's activity state based on the probability,

wherein step (e) further comprises analyzing a time-dependent variation of least one motion waveform, and calculating a mathematical derivative of at least one motion waveform to determine the motion parameter.

2. A method for monitoring a patient, comprising the following steps:

(d) processing the first and second time-dependent physiological waveforms to determine at least one vital sign from the patient;

(e) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter;

(f) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and

(g) estimating the patient's activity state based on the probability,

wherein step (e) further comprises analyzing a time-dependent variation of least one motion waveform, and comparing at least a portion of the motion waveform to a mathematical function.

3. A method for monitoring a patient, comprising the following steps:

(d) processing the first and second time-dependent physiological waveforms to determine at least one vital sign from the patient;

(e) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter;

(f) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and

(g) estimating the patient's activity state based on the probability,

wherein step (e) further comprises calculating an amplitude of at least one frequency component of the power spectrum, or a mathematical derivative thereof, to determine the motion parameter and determining a logit variable z, or a mathematical derivative thereof, wherein z is defined as:

z=b₀+b₁x₁+b₂x₂+ . . . +b_mx_m

wherein b₀, b₁, b₂, and b_mare predetermined constants related to motion, and at least one of x₀, x₁, x₂, and x_mis a motion parameter determined from an amplitude of at least one frequency component of the power spectrum.

4. The method of claim 3, wherein step (f) further comprises processing the logit variable z, or a mathematical derivative thereof, with a mathematical function to determine the probability that the patient is undergoing a specific activity state.

5. The method of claim 4, wherein step (f) further comprises processing the logit variable z, or a mathematical derivative thereof, with a probability function P, or a mathematical derivative thereof, wherein P is defined as:

P = \frac{1}{1 - \exp (- z)}

and wherein P indicates a probability of an activity state.

6. The method of claim 5, wherein step (g) further comprises comparing P, or a mathematical derivative thereof, to a predetermined threshold value to estimate the patient's activity state.

7. The method of claim 5, wherein each of the first and second time-dependent physiological waveforms are selected from a group consisting of an optical waveform, an electrical waveform, an acoustic waveform, and a pressure waveform.

8. The method of claim 7, wherein steps (a) and (b) each further comprise detecting a time-dependent physiological waveform with a sensor selected from a group consisting of: (i) an optical sensor comprising a light source and a photodiode; (ii) an electrical sensor comprising at least two electrodes operably connected to an electrical circuit; (iii) an acoustic sensor comprising a microphone; and (iv) a pressure sensor comprising a transducer.

9. A method for monitoring a patient, comprising the following steps:

(d) processing the first and second time-dependent physiological waveforms to determine at least one vital sign from the patient;

(e) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter;

(f) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and

(g) estimating the patient's activity state based on the probability,

wherein step (e) further comprises analyzing a time-dependent variation of least one motion waveform, and determining a logit variable z, or a mathematical derivative thereof, wherein z is defined as:

z=b₀+b₁x₁+b₂x₂+ . . . +b_mx_m

wherein b₁, b₁, b₂, and b_mare predetermined constants related to motion, and at least one of x₀, x₁, x₂, and x_mis a motion parameter determined from a time-dependent variation of least one motion waveform.

10. The method of claim 9, wherein step (f) further comprises processing the logit variable z, or a mathematical derivative thereof, with a mathematical function to determine the probability that the patient is undergoing a specific activity state.

11. The method of claim 10, wherein step (f) further comprises processing the logit variable z, or a mathematical derivative thereof, with a probability function P, or a mathematical derivative thereof, wherein P is defined as:

P = \frac{1}{1 - \exp (- z)}

and wherein P indicates a probability of an activity state.

12. The method of claim 11, wherein step (g) further comprises comparing P, or a mathematical derivative thereof, to a predetermined threshold value to estimate the patient's activity state.

13. The method of claim 9, wherein the first time-dependent physiological waveform is an electrical waveform, and step (a) further comprises detecting the electrical waveform with at least two electrodes attached to the patient and operably connected to an electrical circuit.

14. The method of claim 13, wherein the second time-dependent physiological waveform is an optical waveform, and step (b) further comprises detecting the optical waveform with an optical sensor comprising a light source and a photodiode.

15. A method for monitoring a patient, comprising the following steps:

(d) processing the first and second time-dependent physiological waveforms to determine at least one vital sign from the patient;

(e) analyzing at least a portion of each set of time-dependent motion waveforms, or a mathematical derivative thereof, to determine a motion parameter;

(f) processing the motion parameter to determine a probability that the patient is undergoing a specific activity state; and

(g) estimating the patient's activity state based on the probability,

wherein step (d) further comprises determining at least one vital sign by calculating a time difference between a feature in the first time-dependent physiological waveform and a feature in the second time-dependent physiological waveform.

16. The method of claim 15, wherein step (d) further comprises calculating a blood pressure from the time difference.

Patent Citations (352)

Patent	Date	Inventor	Cited By
US4270547(A)	1981-06-01	Steffen et al.	Applicant
US4305400(A)	1981-12-01	Logan	Applicant
US4577639(A)	1986-03-01	Simon et al.	Applicant
US4653498(A)	1987-03-01	New, Jr. et al.	Applicant
US4710164(A)	1987-12-01	Levin et al.	Applicant
US4802486(A)	1989-02-01	Goodman et al.	Applicant
US4905697(A)	1990-03-01	Heggs et al.	Examiner
US5025791(A)	1991-06-01	Niwa	Applicant
US5140990(A)	1992-08-01	Jones et al.	Applicant
US5247931(A)	1993-09-01	Norwood	Applicant
US5316008(A)	1994-05-01	Suga et al.	Applicant
US5339818(A)	1994-08-01	Baker et al.	Applicant
US5465082(A)	1995-11-01	Chaco	Applicant
US5482036(A)	1996-01-01	Diab et al.	Applicant
US5490505(A)	1996-02-01	Diab et al.	Applicant
US5515858(A)	1996-05-01	Myllymaki	Applicant
US5524637(A)	1996-06-01	Erickson	Applicant
US5549650(A)	1996-08-01	Bornzin et al.	Applicant
US5593431(A)	1997-01-01	Sheldon	Applicant
US5632272(A)	1997-05-01	Diab et al.	Applicant
US5649543(A)	1997-07-01	Hosaka et al.	Applicant
US5685299(A)	1997-11-01	Diab et al.	Applicant
US5769785(A)	1998-06-01	Diab et al.	Applicant
US5800349(A)	1998-09-01	Isaacson et al.	Applicant
US5848373(A)	1998-12-01	DeLorme et al.	Applicant
US5853370(A)	1998-12-01	Chance et al.	Applicant
US5857975(A)	1999-01-01	Golub	Applicant
US5865755(A)	1999-02-01	Golub	Applicant
US5876353(A)	1999-03-01	Riff	Applicant
US5899855(A)	1999-05-01	Brown	Applicant
US5913827(A)	1999-06-01	Gorman	Applicant
US5919141(A)	1999-07-01	Money et al.	Applicant
US5941836(A)	1999-08-01	Friedman	Applicant
US5964701(A)	1999-10-01	Asada et al.	Applicant
US5971930(A)	1999-10-01	Elghazzawi	Applicant
US6002952(A)	1999-12-01	Diab et al.	Applicant
US6018673(A)	2000-01-01	Chin et al.	Applicant
US6036642(A)	2000-03-01	Diab et al.	Applicant
US6041783(A)	2000-03-01	Gruenke	Applicant
US6057758(A)	2000-05-01	Dempsey et al.	Applicant
US6067462(A)	2000-05-01	Diab et al.	Applicant
US6081735(A)	2000-06-01	Diab et al.	Applicant
US6081742(A)	2000-06-01	Amano et al.	Applicant
US6094592(A)	2000-07-01	Yorkey et al.	Applicant
US6117077(A)	2000-09-01	Del Mar et al.	Applicant
US6129686(A)	2000-10-01	Friedman	Applicant
US6157850(A)	2000-12-01	Diab et al.	Applicant
US6160478(A)	2000-12-01	Jacobsen et al.	Applicant
US6198394(B1)	2001-03-01	Jacobsen et al.	Applicant
US6199550(B1)	2001-03-01	Wiesmann et al.	Applicant
US6236872(B1)	2001-05-01	Diab et al.	Applicant
US6251080(B1)	2001-06-01	Henkin et al.	Applicant
US6261247(B1)	2001-07-01	Ishikawa et al.	Applicant
US6262769(B1)	2001-07-01	Anderson et al.	Applicant
US6263222(B1)	2001-07-01	Diab et al.	Applicant
US6334065(B1)	2001-12-01	Al-Ali et al.	Applicant
US6371921(B1)	2002-04-01	Caro et al.	Applicant
USRE37852(E)	2002-09-01	Aso et al.	Applicant
US6443890(B1)	2002-09-01	Schulze et al.	Applicant
US6491647(B1)	2002-12-01	Bridger et al.	Applicant
US6516289(B2)	2003-02-01	David	Applicant
US6526310(B1)	2003-02-01	Carter et al.	Applicant
US6527729(B1)	2003-03-01	Turcott	Applicant
US6544173(B2)	2003-04-01	West et al.	Applicant
US6544174(B2)	2003-04-01	West et al.	Applicant
US6546267(B1)	2003-04-01	Sugiura et al.	Applicant
US6551252(B2)	2003-04-01	Sackner et al.	Applicant
US6584336(B1)	2003-06-01	Ali et al.	Applicant
US6589170(B1)	2003-07-01	Flach et al.	Applicant
US6605038(B1)	2003-08-01	Teller et al.	Applicant
US6606993(B1)	2003-08-01	Wiesmann et al.	Applicant
US6616606(B1)	2003-09-01	Petersen et al.	Applicant
US6650917(B2)	2003-11-01	Diab et al.	Applicant
US6694177(B2)	2004-02-01	Eggers et al.	Applicant
US6699194(B1)	2004-03-01	Diab et al.	Applicant
US6732064(B1)	2004-05-01	Kadtke et al.	Applicant
US6745060(B2)	2004-06-01	Diab et al.	Applicant
US6770028(B1)	2004-08-01	Ali et al.	Applicant
US6790178(B1)	2004-09-01	Mault et al.	Applicant
US6845256(B2)	2005-01-01	Chin et al.	Applicant
US6879850(B2)	2005-04-01	Kimball	Applicant
US6893396(B2)	2005-05-01	Schulze et al.	Applicant
US6934571(B2)	2005-08-01	Wiesmann et al.	Applicant
US6947781(B2)	2005-09-01	Asada et al.	Applicant
US6976958(B2)	2005-12-01	Quy	Applicant
US6985078(B2)	2006-01-01	Suzuki et al.	Applicant
US6997882(B1)	2006-02-01	Parker et al.	Applicant
US7020508(B2)	2006-03-01	Stivoric et al.	Applicant
US7020578(B2)	2006-03-01	Sorensen et al.	Applicant
US7041060(B2)	2006-05-01	Flaherty et al.	Applicant
US7115824(B2)	2006-10-01	Lo	Applicant
US7156809(B2)	2007-01-01	Quy	Applicant
US7194293(B2)	2007-03-01	Baker, Jr.	Applicant
US7215984(B2)	2007-05-01	Diab et al.	Applicant
US7241265(B2)	2007-07-01	Cummings et al.	Applicant
US7257438(B2)	2007-08-01	Kinast	Applicant
US7299159(B2)	2007-11-01	Nanikashvili	Examiner
US7301451(B2)	2007-11-01	Hastings	Applicant
US7314451(B2)	2008-01-01	Halperin et al.	Applicant
US7382247(B2)	2008-06-01	Welch et al.	Applicant
US7384398(B2)	2008-06-01	Gagnadre et al.	Applicant
US7420472(B2)	2008-09-01	Tran	Applicant
US7427926(B2)	2008-09-01	Sinclair et al.	Applicant
US7455643(B1)	2008-11-01	Li et al.	Applicant
US7468036(B1)	2008-12-01	Rulkov et al.	Applicant
US7477143(B2)	2009-01-01	Albert	Applicant
US7485095(B2)	2009-02-01	Shusterman	Applicant
US7502643(B2)	2009-03-01	Farringdon et al.	Applicant
US7508307(B2)	2009-03-01	Albert	Applicant
US7509131(B2)	2009-03-01	Krumm et al.	Applicant
US7522035(B2)	2009-04-01	Albert	Applicant
US7539532(B2)	2009-05-01	Tran	Applicant
US7541939(B2)	2009-06-01	Zadesky et al.	Applicant
US7542878(B2)	2009-06-01	Nanikashvili	Applicant
US7586418(B2)	2009-09-01	Cuddihy et al.	Applicant
US7598878(B2)	2009-10-01	Goldreich	Applicant
US7602301(B1)	2009-10-01	Stirling et al.	Applicant
US7616110(B2)	2009-11-01	Crump et al.	Applicant
US7625344(B1)	2009-12-01	Brady et al.	Applicant
US7628071(B2)	2009-12-01	Sasaki et al.	Applicant
US7628730(B1)	2009-12-01	Watterson et al.	Applicant
US7641614(B2)	2010-01-01	Asada et al.	Applicant
US7648463(B1)	2010-01-01	Elhag et al.	Applicant
US7656287(B2)	2010-02-01	Albert et al.	Applicant
US7668588(B2)	2010-02-01	Kovacs	Applicant
US7670295(B2)	2010-03-01	Sackner et al.	Applicant
US7674230(B2)	2010-03-01	Reisfeld	Applicant
US7674231(B2)	2010-03-01	McCombie et al.	Applicant
US7678061(B2)	2010-03-01	Lee et al.	Applicant
US7684954(B2)	2010-03-01	Shahabdeen et al.	Applicant
US7689437(B1)	2010-03-01	Teller et al.	Applicant
US7698101(B2)	2010-04-01	Alten et al.	Applicant
US7698830(B2)	2010-04-01	Townsend et al.	Applicant
US7698941(B2)	2010-04-01	Sasaki et al.	Applicant
US7715984(B2)	2010-05-01	Ramakrishnan et al.	Applicant
US7782189(B2)	2010-08-01	Spoonhower et al.	Applicant
US7976480(B2)	2011-07-01	Grajales et al.	Applicant
US8137270(B2)	2012-03-01	Keenan et al.	Applicant
US2001/0004234(A1)	2001-06-01	Petelenz et al.	Applicant
US2001/0013826(A1)	2001-08-01	Ahmed et al.	Applicant
US2002/0013517(A1)	2002-01-01	West et al.	Applicant
US2002/0032386(A1)	2002-03-01	Sackner et al.	Applicant
US2002/0072859(A1)	2002-06-01	Kajimoto et al.	Applicant
US2002/0151805(A1)	2002-10-01	Sugo et al.	Applicant
US2002/0156354(A1)	2002-10-01	Larson	Applicant
US2002/0170193(A1)	2002-11-01	Townsend et al.	Applicant
US2002/0198679(A1)	2002-12-01	Victor et al.	Applicant
US2003/0130590(A1)	2003-07-01	Bui et al.	Applicant
US2003/0135099(A1)	2003-07-01	Al-Ali	Applicant
US2003/0153836(A1)	2003-08-01	Gagnadre et al.	Applicant
US2003/0158699(A1)	2003-08-01	Townsend et al.	Applicant
US2003/0167012(A1)	2003-09-01	Friedman et al.	Applicant
US2003/0181815(A1)	2003-09-01	Ebner et al.	Applicant
US2003/0208335(A1)	2003-11-01	Unuma et al.	Applicant
US2004/0030261(A1)	2004-02-01	Rantala	Applicant
US2004/0034293(A1)	2004-02-01	Kimball	Applicant
US2004/0034294(A1)	2004-02-01	Kimball et al.	Applicant
US2004/0054821(A1)	2004-03-01	Warren et al.	Applicant
US2004/0073128(A1)	2004-04-01	Hatlestad et al.	Applicant
US2004/0077934(A1)	2004-04-01	Massad	Applicant
US2004/0122315(A1)	2004-06-01	Krill	Applicant
US2004/0133079(A1)	2004-07-01	Mazar et al.	Applicant
US2004/0162466(A1)	2004-08-01	Quy	Applicant
US2004/0162493(A1)	2004-08-01	Mills	Applicant
US2004/0225207(A1)	2004-11-01	Bae et al.	Applicant
US2004/0267099(A1)	2004-12-01	McMahon et al.	Applicant
US2005/0027205(A1)	2005-02-01	Tarassenko et al.	Applicant
US2005/0113107(A1)	2005-05-01	Meunier	Applicant
US2005/0113703(A1)	2005-05-01	Farringdon et al.	Applicant
US2005/0124866(A1)	2005-06-01	Elaz et al.	Applicant
US2005/0124903(A1)	2005-06-01	Roteliuk et al.	Applicant
US2005/0149350(A1)	2005-07-01	Kerr et al.	Applicant
US2005/0187796(A1)	2005-08-01	Rosenfeld et al.	Applicant
US2005/0206518(A1)	2005-09-01	Welch et al.	Applicant
US2005/0209511(A1)	2005-09-01	Heruth et al.	Examiner
US2005/0228296(A1)	2005-10-01	Banet	Applicant
US2005/0228298(A1)	2005-10-01	Banet et al.	Applicant
US2005/0228301(A1)	2005-10-01	Banet et al.	Applicant
US2005/0240087(A1)	2005-10-01	Keenan et al.	Applicant
US2005/0261565(A1)	2005-11-01	Lane et al.	Applicant
US2005/0261593(A1)	2005-11-01	Zhang et al.	Applicant
US2005/0265267(A1)	2005-12-01	Hwang	Applicant
US2005/0283088(A1)	2005-12-01	Bernstein	Applicant
US2006/0036141(A1)	2006-02-01	Kamath et al.	Applicant
US2006/0074322(A1)	2006-04-01	Nitzan	Applicant
US2006/0128263(A1)	2006-06-01	Baird	Applicant
US2006/0155589(A1)	2006-07-01	Lane et al.	Applicant
US2006/0178591(A1)	2006-08-01	Hempfling	Applicant
US2006/0200029(A1)	2006-09-01	Evans et al.	Applicant
US2006/0265246(A1)	2006-11-01	Hoag	Applicant
US2006/0270949(A1)	2006-11-01	Mathie et al.	Applicant
US2006/0271404(A1)	2006-11-01	Brown	Applicant
US2006/0281979(A1)	2006-12-01	Kim et al.	Applicant
US2007/0055163(A1)	2007-03-01	Asada et al.	Applicant
US2007/0066910(A1)	2007-03-01	Inukai et al.	Applicant
US2007/0071643(A1)	2007-03-01	Hall et al.	Applicant
US2007/0094045(A1)	2007-04-01	Cobbs et al.	Applicant
US2007/0118056(A1)	2007-05-01	Wang et al.	Applicant
US2007/0129769(A1)	2007-06-01	Bourget et al.	Applicant
US2007/0142715(A1)	2007-06-01	Banet et al.	Applicant
US2007/0156456(A1)	2007-07-01	McGillin et al.	Applicant
US2007/0161912(A1)	2007-07-01	Zhang et al.	Applicant
US2007/0188323(A1)	2007-08-01	Sinclair et al.	Applicant
US2007/0193834(A1)	2007-08-01	Pai et al.	Applicant
US2007/0208233(A1)	2007-09-01	Kovacs	Applicant
US2007/0232867(A1)	2007-10-01	Hansmann	Applicant
US2007/0237719(A1)	2007-10-01	Jones et al.	Applicant
US2007/0244376(A1)	2007-10-01	Wang	Applicant
US2007/0252853(A1)	2007-11-01	Park et al.	Applicant
US2007/0255116(A1)	2007-11-01	Mehta et al.	Applicant
US2007/0270671(A1)	2007-11-01	Gal	Applicant
US2007/0282208(A1)	2007-12-01	Jacobs et al.	Applicant
US2007/0287386(A1)	2007-12-01	Agrawal et al.	Applicant
US2007/0293781(A1)	2007-12-01	Sims et al.	Applicant
US2008/0004904(A1)	2008-01-01	Tran	Applicant
US2008/0039731(A1)	2008-02-01	McCombie et al.	Applicant
US2008/0077027(A1)	2008-03-01	Allgeyer	Applicant
US2008/0082001(A1)	2008-04-01	Hatlestad et al.	Examiner
US2008/0101160(A1)	2008-05-01	Besson	Applicant
US2008/0103405(A1)	2008-05-01	Banet et al.	Applicant
US2008/0114220(A1)	2008-05-01	Banet et al.	Applicant
US2008/0132106(A1)	2008-06-01	Burnes et al.	Applicant
US2008/0139955(A1)	2008-06-01	Hansmann et al.	Applicant
US2008/0146887(A1)	2008-06-01	Rao et al.	Applicant
US2008/0146892(A1)	2008-06-01	LeBoeuf et al.	Applicant
US2008/0161707(A1)	2008-07-01	Farringdon et al.	Applicant
US2008/0162496(A1)	2008-07-01	Postrel	Applicant
US2008/0167535(A1)	2008-07-01	Stivoric et al.	Applicant
US2008/0171927(A1)	2008-07-01	Yang et al.	Applicant
US2008/0194918(A1)	2008-08-01	Kulik et al.	Applicant
US2008/0195735(A1)	2008-08-01	Hodges et al.	Applicant
US2008/0204254(A1)	2008-08-01	Kazuno	Applicant
US2008/0208013(A1)	2008-08-01	Zhang et al.	Applicant
US2008/0221399(A1)	2008-09-01	Zhou et al.	Applicant
US2008/0221404(A1)	2008-09-01	Tso	Applicant
US2008/0275349(A1)	2008-11-01	Halperin et al.	Applicant
US2008/0281168(A1)	2008-11-01	Gibson et al.	Applicant
US2008/0281310(A1)	2008-11-01	Dunning et al.	Applicant
US2008/0294019(A1)	2008-11-01	Tran	Applicant
US2008/0319282(A1)	2008-12-01	Tran	Applicant
US2008/0319327(A1)	2008-12-01	Banet et al.	Applicant
US2009/0018409(A1)	2009-01-01	Banet et al.	Applicant
US2009/0018453(A1)	2009-01-01	Banet et al.	Applicant
US2009/0040041(A1)	2009-02-01	Janetis et al.	Applicant
US2009/0054752(A1)	2009-02-01	Jonnalagadda et al.	Applicant
US2009/0069642(A1)	2009-03-01	Gao et al.	Applicant
US2009/0076363(A1)	2009-03-01	Bly et al.	Applicant
US2009/0076397(A1)	2009-03-01	Libbus et al.	Applicant
US2009/0076398(A1)	2009-03-01	Li et al.	Applicant
US2009/0076405(A1)	2009-03-01	Amurthur et al.	Applicant
US2009/0082681(A1)	2009-03-01	Yokoyama et al.	Applicant
US2009/0112281(A1)	2009-04-01	Miyazawa et al.	Applicant
US2009/0118626(A1)	2009-05-01	Moon et al.	Applicant
US2009/0198139(A1)	2009-08-01	Lewicke et al.	Applicant
US2009/0221937(A1)	2009-09-01	Smith et al.	Applicant
US2009/0222119(A1)	2009-09-01	Plahey et al.	Applicant
US2009/0227877(A1)	2009-09-01	Tran	Applicant
US2009/0233770(A1)	2009-09-01	Vincent et al.	Applicant
US2009/0259113(A1)	2009-10-01	Liu et al.	Applicant
US2009/0262074(A1)	2009-10-01	Nasiri et al.	Applicant
US2009/0295541(A1)	2009-12-01	Roof	Applicant
US2009/0306485(A1)	2009-12-01	Bell	Applicant
US2009/0306487(A1)	2009-12-01	Crowe et al.	Applicant
US2009/0306524(A1)	2009-12-01	Muhlsteff et al.	Applicant
US2009/0312973(A1)	2009-12-01	Hatlestad et al.	Examiner
US2009/0318779(A1)	2009-12-01	Tran	Applicant
US2010/0010380(A1)	2010-01-01	Panken et al.	Examiner
US2010/0030034(A1)	2010-02-01	Schulhauser et al.	Applicant
US2010/0030085(A1)	2010-02-01	Rojas Ojeda et al.	Applicant
US2010/0056881(A1)	2010-03-01	Libbus et al.	Applicant
US2010/0056886(A1)	2010-03-01	Hurtubise et al.	Applicant
US2010/0113948(A1)	2010-05-01	Yang et al.	Applicant
US2010/0125188(A1)	2010-05-01	Schilling et al.	Applicant
US2010/0130811(A1)	2010-05-01	Leuthardt et al.	Applicant
US2010/0160793(A1)	2010-06-01	Lee et al.	Applicant
US2010/0160794(A1)	2010-06-01	Banet et al.	Applicant
US2010/0160795(A1)	2010-06-01	Banet et al.	Applicant
US2010/0160796(A1)	2010-06-01	Banet et al.	Applicant
US2010/0160797(A1)	2010-06-01	Banet et al.	Applicant
US2010/0160798(A1)	2010-06-01	Banet et al.	Applicant
US2010/0168589(A1)	2010-07-01	Banet et al.	Applicant
US2010/0217099(A1)	2010-08-01	LeBoeuf et al.	Applicant
US2010/0222649(A1)	2010-09-01	Schoenberg	Applicant
US2010/0234786(A1)	2010-09-01	Fulkerson et al.	Applicant
US2010/0241011(A1)	2010-09-01	McCombie et al.	Applicant
US2010/0280440(A1)	2010-11-01	Skelton et al.	Examiner
US2010/0298650(A1)	2010-11-01	Moon et al.	Applicant
US2010/0298651(A1)	2010-11-01	Moon et al.	Applicant
US2010/0298652(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298653(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298654(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298655(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298656(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298657(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298658(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298659(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298660(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0298661(A1)	2010-11-01	McCombie et al.	Applicant
US2010/0312115(A1)	2010-12-01	Dentinger	Applicant
US2010/0324384(A1)	2010-12-01	Moon et al.	Applicant
US2010/0324385(A1)	2010-12-01	Moon et al.	Applicant
US2010/0324386(A1)	2010-12-01	Moon et al.	Applicant
US2010/0324387(A1)	2010-12-01	Moon et al.	Applicant
US2010/0324388(A1)	2010-12-01	Moon et al.	Applicant
US2010/0324389(A1)	2010-12-01	Moon et al.	Applicant
US2010/0331640(A1)	2010-12-01	Medina	Applicant
US2011/0066006(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066007(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066008(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066009(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066010(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066037(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066038(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066039(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066043(A1)	2011-03-01	Banet et al.	Applicant
US2011/0066044(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066045(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066050(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066051(A1)	2011-03-01	Moon et al.	Applicant
US2011/0066062(A1)	2011-03-01	Banet et al.	Applicant
US2011/0093281(A1)	2011-04-01	Plummer et al.	Applicant
US2011/0144456(A1)	2011-06-01	Muhlsteff et al.	Applicant
US2011/0152632(A1)	2011-06-01	Le Neel et al.	Applicant
US2011/0224498(A1)	2011-09-01	Banet et al.	Applicant
US2011/0224499(A1)	2011-09-01	Banet et al.	Applicant
US2011/0224500(A1)	2011-09-01	Banet et al.	Applicant
US2011/0224506(A1)	2011-09-01	Moon et al.	Applicant
US2011/0224507(A1)	2011-09-01	Banet et al.	Applicant
US2011/0224508(A1)	2011-09-01	Moon	Applicant
US2011/0224556(A1)	2011-09-01	Moon et al.	Applicant
US2011/0224557(A1)	2011-09-01	Banet et al.	Applicant
US2011/0224564(A1)	2011-09-01	Moon et al.	Applicant
US2011/0257489(A1)	2011-10-01	Banet et al.	Applicant
US2011/0257551(A1)	2011-10-01	Banet et al.	Applicant
US2011/0257552(A1)	2011-10-01	Banet et al.	Applicant
US2011/0257554(A1)	2011-10-01	Banet et al.	Applicant
US2011/0257555(A1)	2011-10-01	Banet et al.	Applicant
US2011/0275907(A1)	2011-11-01	Inciardi et al.	Applicant
US2012/0065525(A1)	2012-03-01	Douniama et al.	Applicant
GB2329250(A)	1999-03-01		Applicant
WO9932030(A1)	1999-07-01		Applicant
WO2006005169(A1)	2006-01-01		Applicant
WO2007143535(A2)	2007-12-01		Applicant
WO2008037820(A1)	2008-04-01		Applicant
WO2010135516(A2)	2010-11-01		Applicant
WO2010135518(A1)	2010-11-01		Applicant
WO2010148205(A1)	2010-12-01		Applicant
WO2011032132(A2)	2011-03-01		Applicant
WO2011034881(A1)	2011-03-01		Applicant
WO2011082341(A1)	2011-07-01		Applicant
WO2011112782(A1)	2011-09-01		Applicant
WO2011133582(A1)	2011-10-01		Applicant

Non-Patent Literature (103)

Otto, et al., “System Architecture of a Wireless Body Area Sensor Network for Ubiquitous Health Monitoring”, Journal of Mobile Multimedia, 1(4):307-326 2006.Applicant
International Search Report and Written Opinion mailed Oct. 15, 2010 in PCT/US2010/035550.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jun. 11, 2012 in U.S. Appl. No. 12/469,222.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jun. 8, 2012 in U.S. Appl. No. 12/650,383.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jun. 8, 2012 in U.S. Appl. No. 12/650,392.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jun. 20, 2012 in U.S. Appl. No. 12/762,751.Applicant
International Search Report and Written Opinion dated Jun. 29, 2012 issued in PCT/US2012/025640.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jul. 5, 2012 in U.S. Appl. No. 12/560,138.Applicant
Signal Strength. Oct. 6, 2008. http://web.archive.org/web/20081 006200523/http:/len.wikipedia.org/wiki/Signal—strength.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 24, 2012 in U.S. Appl. No. 12/560,111.Applicant
Restriction Requirement issued by the US Patent and Trademark Office on Apr. 24, 2012 in U.S. Appl. No. 12/469,107.Applicant
Response to Restriction Requirement submitted Jun. 14, 2012 in U.S. Appl. No. 12/469,107.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Jul. 18, 2012 in U.S. Appl. No. 12/650,389.Applicant
Chan et al., Noninvasive and Cuffless Measurements of Blood Pressure for Telemedicine. Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2001:3 pages.Applicant
Fung, Advisory System for Administration of Phenylephrine Following Spinal Anesthesia for Cesarean Section. Master's Thesis. University of British Columbia 2002: 119 pages.Applicant
Liu et al., The Changes in Pulse Transit Time at Specific Cuff Pressures during Inflation and Deflation. Proceedings of the 28th IEEE EMBS Annual International Conference New York City, USA, Aug. 30-Sep. 3, 2006:6404-6405.Applicant
Nitzan et al., Effects of External Pressure on Arteries Distal to the Cuff During Sphygmomanometry. IEEE Transactions on Biomedical Engineering, Jun. 2005;52(6):1120-1127.Applicant
USB 2.0 Specification Engineering Change Notice. Oct. 20, 2000.Applicant
Yan and Zhang, A Novel Calibration Method for Noninvasive Blood Pressure Measurement Using Pulse Transit Time. Proceedings of the 4th IEEE-EMBS International Summer School and Symposium on Medical Devices and Biosensors St Catharine's College,Cambridge, UK, Aug. 19-22, 2007.Applicant
Zislin et al., Ways of Improving the Accuracy of Arterial Pressure Oscillometry. Biomedical Engineering 2005;39 (4):174-178.Applicant
International Search Report and Written Opinion dated May 29, 2012 issued in PCT/US2012/025648.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 3, 2012 in U.S. Appl. No. 12/762,925.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 3, 2012 in U.S. Appl. No. 12/762,963.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 20, 2012 in U.S. Appl. No. 12/762,777.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 21, 2012 in U.S. Appl. No. 12/469,107.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 24, 2012 in U.S. Appl. No. 12/762,936.Applicant
International Search Report and Written Opinion dated Jul. 22, 2011 issued in PCT/US2011/027843.Applicant
International Search Report and Written Opinion dated Jul. 20, 2011 issued in PCT/US2011/033100.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 26, 2011 in U.S. Appl. No. 12/469,151.Applicant
Response to Non-Final Office Action submitted Nov. 25, 2011 in U.S. Appl. No. 12/469,151.Applicant
Notice of Allowance issued by the US Patent and Trademark Office on Feb. 1, 2012 in U.S. Appl. No. 12/469,151.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Aug. 4, 2011 in U.S. Appl. No. 12/469,182.Applicant
Response to Non-Final Office Action submitted Nov. 25, 2011 in U.S. Appl. No. 12/469,182.Applicant
Notice of Allowance issued by the US Patent and Trademark Office on Dec. 28, 2011 in U.S. Appl. No. 12/469,182.Applicant
International Search Report and Written Opinion dated Oct. 15, 2010 issued in PCT/US2010/035550.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 12, 2012 in U.S. Appl. No. 12/559,429.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 12, 2012 in U.S. Appl. No. 12/559,430.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 24, 2012 in U.S. Appl. No. 12/559,435.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 25, 2012 in U.S. Appl. No. 12/762,733.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 27, 2012 in U.S. Appl. No. 12/762,822.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 27, 2012 in U.S. Appl. No. 12/559,422.Applicant
Mathie, Monitoring and Interpreting Human Movement Patterns using a Triaxial Accelerometer. Faculty of Engineering. The University of New South Wales. PhD Dissertation. Aug. 2003: part1 pp. 1-256.Applicant
Mathie, Monitoring and Interpreting Human Movement Patterns using a Triaxial Accelerometer. Faculty of Engineering. The University of New South Wales. PhD Dissertation. Aug. 2003: part2 pp. 256-512.Applicant
International Search Report and Written Opinion dated Apr. 27, 2012 as reported in PCT/US2011/067441.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 7, 2012 in U.S. Appl. No. 12/469,115.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 9, 2012 in U.S. Appl. No. 12/762,836.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 10, 2012 in U.S. Appl. No. 12/559,419.Applicant
Jackson, Digital Filter Design and Synthesis Using High-Level Modeling Tools. Virginia Polytechnic Institute and State University Thesis. Dec. 1999.Applicant
Kim et al., Two Algorithms for Detecting Respiratory Rate from ECG Signal. IFMBE Proceedings 2007;14(6) JC27:4069-4071.Applicant
O'Haver, Peak Finding and Measurement, Version 1.6 Oct. 26, 2006. http://web.archive.org/web/20090205162604/http://terpconnect.umd.edu/-toh/spectrum/PeakFindingandMeasurement.htm.Applicant
Reinvuo et al., Measurement of Respiratory Rate with High-Resolution Accelerometer and EMFit Pressure Sensor. Proceedings of the 2006 IEEE Sensors Applications Symposium Feb. 7-9, 2006:192-195.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 11, 2012 in U.S. Appl. No. 12/762,846.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on May 11, 2012 in U.S. Appl. No. 12/762,874.Applicant
Allen et al., Classification of a known sequence of motions and postures from accelerometry data using adapted Gaussian mixture models. Physiol. Meas. 2006;27:935-951.Applicant
Asada et al., Active Noise Cancellation Using MEMS Accelerometers for Motion-Tolerant Wearable Bio-Sensors. Proceedings of the 26th Annual International Conference of the IEEE EMBS. San Francisco, CA, USA. Sep. 1-5, 2004:2157-2160.Applicant
Bowers et al., Respiratory Rate Derived from Principal Component Analysis of Single Lead Electrocardiogram. Computers in Cardiology Conference Proceedings Sep. 2008;35:437-440.Applicant
Bussmann et al., Measuring daily behavior using ambulatory accelerometry: The Activity Monitor. Behav Res Methods Instrum Comput. Aug. 2001;33(3):349-356.Applicant
Cretikos et al., The Objective Medical Emergency Team Activation Criteria: a case—control study. Resuscitation Apr. 2007;73(1):62-72.Applicant
Espina et al., Wireless Body Sensor Network for Continuous Cuff-less Blood Pressure Monitoring. Proceedings of the 3rd IEEE-EMBS. International Summer School and Symposium on Medical Devices and Biosensors. MIT, Boston, USA, Sep. 4-6, 2006:11-15.Applicant
Fieselmann et al., Respiratory rate predicts cardiopulmonary arrest for internal medicine patients. J Gen Intern Med Jul. 1993;8(7):354-360.Applicant
Goldhill et al., A physiologically-based early warning score for ward patients: the association between score and outcome. Anaesthesia Jun. 2005;60(6):547-553.Applicant
Hung et al., Estimation of Respiratory Waveform Using an Accelerometer. 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, May 14-17, 2008:1493-1496.Applicant
Jin, A Respiration Monitoring System Based on a Tri-Axial Accelerometer and an Air-Coupled Microphone. Technische Universiteit Eindhoven, University of Technology. Master's Graduation Paper, Electrical Engineering Aug. 25, 2009.Applicant
Karantonis et al., Implementation of a Real-Time Human Movement Classifier Using a Triaxial Accelerometer for Ambulatory Monitoring. IEEE Transactions on Information Technology in Biomedicine. Jan. 2006;10(1):156-167.Applicant
Khambete et al., Movement artefact rejection in impedance pneumography using six strategically placed electrodes. Physiol. Meas. 2000;21:79-88.Applicant
Khan et al., Accelerometer Signal-based Human Activity Recognition Using Augmented Autoregressive Model Coefficients and Artificial w Neural Nets. 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Aug. 20-24, 2008:5172-5175.Applicant
Mason, Signal Processing Methods for Non-Invasive Respiration Monitoring. Department of Engineering Science, University of Oxford 2002.Applicant
Mathie et al., Classification of basic daily movements using a triaxial accelerometer. Med Biol Eng Comput. Sep. 2004;42(5):679-687.Applicant
Otto et al., System Architecture of a Wireless Body Area Sensor Network for Ubiquitous Health Monitoring. Journal of Mobile Multimedia Jan. 10, 2006;1(4):307-326.Applicant
Park et al., An improved algorithm for respiration signal extraction from electrocardiogram measured by conductive textile electrodes using instantaneous frequency estimation. Med Bio Eng Comput 2008;46:147-158.Applicant
PDF-Pro for iPhone & iPod touch User Manual. ePapyrus Jul. 2009;1:1-25 http://epapyrus.com/en/files/PDFPro%.Applicant
Seo et al., Performance Improvement of Pulse Oximetry-Based Respiration Detection by Selective Mode Bandpass Filtering. Ergonomics and Health Aspects of Work with Computers Lecture Notes in Computer Science, 2007;4566:300-308.Applicant
Soh et al., An investigation of respiration while wearing back belts. Applied Ergonomics 1997; 28(3):189-192.Applicant
Subbe et al., Effect of introducing the Modified Early Warning score on clinical outcomes, cardiopulmonary arrests and intensive care utilization in acute medical admissions. Anaesthesia Aug. 2003;58(8):797-802.Applicant
Vuorela et al., Two portable long-term measurement devices for ECG and bioimpedance. Second International Conference on Pervasive Computing Technologies for Healthcare.. Jan. 30-Feb. 1, 2008: 169-172.Applicant
Wolf et al., Development of a Fall Detector and Classifier based on a Triaxial Accelerometer Demo Board. 2007:210-213.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 30, 2012 in U.S. Appl. No. 12/762,790.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 30, 2012 in U.S. Appl. No. 12/469,236.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 3, 2012 in U.S. Appl. No. 12/469,094.Applicant
Restriction Requirement issued by the US Patent and Trademark Office on Feb. 2, 2012 in U.S. Appl. No. 12/469,222.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 27, 2012 in U.S. Appl. No. 12/559,426.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 3, 2012 in U.S. Appl. No. 12/559,039.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Dec. 29, 2011 in U.S. Appl. No. 12/559,080.Applicant
Response to Non-Final Office Action submitted Mar. 19, 2012 in U.S. Appl. No. 12/559,080.Applicant
Notice of Allowance issued by the US Patent and Trademark Office on Apr. 2, 2012 in U.S. Appl. No. 12/559,080.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Dec. 15, 2011 in U.S. Appl. No. 12/560,077.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 8, 2012 in U.S. Appl. No. 12/560,093.Applicant
Restriction Requirement issued by the US Patent and Trademark Office on Dec. 14, 2012 in U.S. Appl. No. 12/560,093.Applicant
Response to Restriction Requirement submitted Feb. 15, 2012 in U.S. Appl. No. 12/560,093.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 1, 2012 in U.S. Appl. No. 12/560,104.Applicant
Restriction Requirement issued by the US Patent and Trademark Office on Jan. 19, 2012 in U.S. Appl. No. 12/469,115.Applicant
Response to Restriction Requirement submitted Feb. 15, 2012 in U.S. Appl. No. 12/469,115.Applicant
Restriction Requirement issued by the US Patent and Trademark Office on Nov. 14, 2011 in U.S. Appl. No. 12/469,127.Applicant
Response to Restriction Requirement submitted Feb. 15, 2012 in U.S. Appl. No. 12/469,127.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Mar. 9, 2012 in U.S. Appl. No. 12/469,127.Applicant
Non-Final Office Action issued by the US Patent and Trademark Office on Apr. 3, 2012 in U.S. Appl. No. 12/469,137.Applicant
International Preliminary Report on Patentability dated Dec. 1, 2011 issued in PCT/US2010/035554.Applicant
International Search Report and Written Opinion dated Sep. 23, 2010 issued in PCT/US2010/035554.Applicant
International Preliminary Report on Patentability dated Jan. 5, 2012 issued in PCT/US2010/039000.Applicant
International Search Report and Written Opinion dated Sep. 7, 2010 issued in PCT/US2010/039000.Applicant
International Search Report and Written Opinion dated Nov. 3, 2010 issued in PCT/US2010/048729.Applicant
International Search Report and Written Opinion dated Nov. 5, 2010 issued in PCT/US2010/048866.Applicant
International Search Report and Written Opinion dated Mar. 3, 2011 issued in PCT/US2010/062564.Applicant

Abstract

Description

CROSS REFERENCES TO RELATED APPLICATION

[0001] Not Applicable

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] Not Applicable

BACKGROUND OF THE INVENTION

[0003] 1. Field of the Invention

[0004] The present invention relates to medical devices for monitoring vital signs, e.g., arterial blood pressure.

[0005] 2. Description of the Related Art

SUMMARY OF THE INVENTION

[0030]

P = \frac{1}{1 - \exp (- z)}