US 8,353,902 B2Grant

Articulating ablation device and method

Issue Date:2013-01-15

•19 Claims

•5 Drawing Sheets

Abstract

An ablation device including a handle portion, a shaft and at least one cable. The shaft extends distally from the handle portion and includes an inner conductor and an outer conductor that substantially surrounds at least a portion of the inner conductor. The cable extends from the handle portion along at least a portion of the shaft. The distal tip of the inner conductor is positionable distally beyond a distal-most end of the outer conductor. In response to movement of the at least one cable relative to the handle portion, the distal tip of the outer conductor is movable form a first position where the distal tip is substantially aligned with a longitudinal axis defined by the outer conductor to at least a second position where the distal tip is disposed at an angle relative to the longitudinal axis.

Metadata

Assignee

Vivant Medical, Inc.

Inventor

Mani N. Prakash

Application Information

Application Number:US 12/353,623

Filing Date:2009-01-14

Priority Date:2008-01-31

Art Unit:3763

Classifications

IPC:

A61B18/18A61B17/70

Patent Drawings (5 sheets)

Description

Cross-Reference to Related Applications

[0001] This application claims the benefit of priority to U.S. Provisional Application Ser. No. 61/025,206 entitled “ARTICULATING ABLATION DEVICE AND METHOD” filed Jan. 31, 2008 by Mani N. Prakash, which is incorporated by reference herein.

Background

[0002] 1. Technical Field

[0003] The present disclosure relates to ablation devices and methods. More particularly, the disclosure relates to antennas that are insertable into tissue and capable of being articulated and that are useful for laparoscopic and endoscopic procedures.

[0004] 2. Background of Related Art

[0005] In the treatment of diseases, such as cancer, certain types of cancer cells have been found to denature at elevated temperatures that are slightly lower than temperatures normally injurious to healthy cells. These types of treatments, known generally as hyperthermia therapy, typically utilize electromagnetic radiation to heat diseased cells to temperatures above 41° C. while maintaining adjacent healthy cells at lower temperatures where irreversible cell destruction will not occur. Other procedures utilizing electromagnetic radiation to heat tissue also include ablation and coagulation of the tissue. Such microwave ablation procedures, e.g., such as those performed for menorrhagia, are typically done to ablate and coagulate the targeted tissue to denature or kill it. Many procedures and types of devices utilizing electromagnetic radiation therapy are known in the art. Such microwave therapy is typically used in the treatment of tissue and organs such as the prostate, heart, and liver.

[0006] One non-invasive procedure generally involves the treatment of tissue (e.g., a tumor) underlying the skin via the use of microwave energy. The microwave energy is able to non-invasively penetrate the skin to reach the underlying tissue. However, this non-invasive procedure may result in the unwanted heating of healthy tissue. Thus, the non-invasive use of microwave energy requires a great amount of control. This is partly why a more direct and precise method of applying microwave radiation has been sought.

[0007] Presently, there are several types of microwave probes in use, e.g., monopole, dipole, and helical. One type is a monopole antenna probe consisting of a single, elongated microwave conductor exposed at the end of the probe. The probe is sometimes surrounded by a dielectric sleeve. The second type of microwave probe commonly used is a dipole antenna consisting of a coaxial construction having an inner conductor and an outer conductor with a dielectric separating a portion of the inner conductor and a portion of the outer conductor. In the monopole and dipole antenna probe, microwave energy generally radiates perpendicularly from the axis of the conductor.

[0008] Because of the perpendicular pattern of energy radiation, conventional antenna probes are typically designed to be inserted directly into the tissue, e.g., a tumor, to be radiated. However, such typical antenna probes commonly fail to provide uniform heating axially and/or radially about the effective length of the probe.

[0009] It is often difficult to assess the extent to which the energy will radiate into the surrounding tissue, i.e., it is difficult to determine the area or volume of surrounding tissue that will be ablated. Furthermore, when conventional antennas are inserted directly into the tissue, e.g., cancerous tissue, there is a danger of dragging or pulling cancerous cells along the antenna body into other parts of the body during insertion, placement, or removal of the antenna probe.

[0010] One conventional method for inserting and/or localizing wires or guides includes a wire guide that is delivered into breast tissue, for example, through a tubular introducer needle. When deployed, the wire guide cuts into and scribes a helical path about the tissue distal to a lesion while the remainder of the distal portion of the wire guide follows the path scribed by the distal tip and locks about the tissue.

Summary

[0011] The present disclosure relates to an ablation device including a handle portion, a shaft and at least one cable. The shaft extends distally from the handle portion and includes an inner conductor and an outer conductor that substantially surrounds at least a portion of the inner conductor. The cable extends from the handle portion along at least a portion of the shaft. The distal tip of the inner conductor is positionable distally beyond a distal-most end of the outer conductor. In response to movement of the at least one cable relative to the handle portion, the distal tip of the outer conductor is movable form a first position where the distal tip is substantially aligned with a longitudinal axis defined by the outer conductor to at least a second position where the distal tip is disposed at an angle relative to the longitudinal axis.

[0012] The present disclosure also relates to a method of treating tissue. The method includes providing an ablation device. The ablation device includes an antenna and at least one cable. A proximal portion of the antenna defines a longitudinal axis. The at least one cable extends along a portion of the antenna. The method also includes moving the at least one cable such that a distal tip of the antenna moves from a first position where the distal tip is substantially aligned with the longitudinal axis to at least a second position where the distal tip is disposed at an angle to the longitudinal axis.

[0013] The present disclosure also relates to an ablation system for ablating tissue. The ablation system includes an ablation device including a handle portion defining a longitudinal axis and an antenna extending distally from the handle portion. An intermediate portion of the antenna is movable from a first position where a distal tip of the antenna is substantially aligned with the longitudinal axis to at least a second position where the distal tip of the antenna is disposed at an angle to the longitudinal axis.

[0014] The present disclosure also relates to an energy applicator including a handle portion, a shaft, an electrode, and at least one cable. The shaft extends distally from the handle portion and defines a longitudinal axis. The electrode is disposed in electro-mechanical cooperation with the handle portion and is translatable with respect to the shaft. The at least one cable extends between the handle portion and the electrode. At least a portion of the electrode is positionable distally beyond a distal-most end of the shaft. In response to movement of the at least one cable relative to the handle portion, a portion of the electrode is movable from a first position where the electrode is substantially aligned with the longitudinal axis to at least a second position where at least a portion of the electrode is disposed at an angle relative to the longitudinal axis.

Description of the Drawings

[0015] Embodiments of the presently disclosed ablation devices are disclosed herein with reference to the drawings, wherein:

[0016] FIG. 1 is a perspective view of a microwave ablation device in accordance with an embodiment of the present disclosure;

[0017] FIG. 2 is a schematic view of the microwave ablation device of FIG. 1 connected to a generator;

[0018] FIG. 3 is a cross-sectional view of a portion of a shaft of the microwave ablation device of FIGS. 1 and 2, as taken through 3-3 of FIG. 2;

[0019] FIG. 4 is a longitudinal, cross-sectional, plan view of the shaft of the microwave ablation device of FIGS. 1-3, in accordance with an embodiment of the present disclosure;

[0020] FIG. 5 is a longitudinal, cross-sectional view of a distal portion of the microwave ablation device of FIGS. 1-4 at least partially surrounding a treatment area; and

[0021] FIGS. 6 and 7 are longitudinal and transverse cross-sectional views, respectively, of a variation of the feedline of the microwave ablation device of FIG. 3 having plated conductive layers.

Detailed Description of Embodiments

[0022] Embodiments of the presently disclosed ablation devices are described in detail with reference to the drawings, in which like reference numerals designate identical or corresponding elements in each of the several views. As used herein the term “distal” refers to that portion of the ablation device, or component thereof, farther from the user while the term “proximal” refers to that portion of the ablation device or component thereof, closer to the user.

[0023] An energy applicator or ablation device (e.g., a microwave ablation device) in accordance with the present disclosure is referred to in the figures as reference numeral 10. While a microwave ablation device is described herein, it is contemplated that the present disclosure may also be used in connection with other types of ablation devices such as radiofrequency (RF), laser, ultrasound, cryotherapy, etc. Such ablation devices may include an antenna and/or an electrode.

[0024] Referring initially to FIGS. 1 and 2, microwave ablation device 10 includes an antenna 12 and a handle portion 13. Antenna 12 includes a shaft 14 having an inner conductor 16 and an outer conductor 24. A cord 20 is shown to couple microwave ablation device 10 to an electrosurgical generator 22, for instance. In the disclosed embodiments, electrosurgical generator 22 includes at least one of an RF generator and a microwave (MW) generator and may include other modalities including ultrasound and optical, for instance. Additionally, an actuation element 7, a rotation knob 9 and an articulation knob 11 are illustrated in FIG. 1 in accordance with various embodiments of the present disclosure.

[0025] As seen in FIG. 2, inner conductor 16 may be extendable from outer conductor 24 to define an ablation region 29. Several types of inner conductors 16 may be used in connection with the disclosed microwave ablation device 10, including an inner conductor 16 configured to deploy substantially in line with outer conductor 24 (e.g., FIG. 1) and an inner conductor 16 configured to deploy in a curved orientation (e.g., FIGS. 2 and 5) along a curvilinear path. In the embodiment illustrated in FIG. 2, a proximal end of shaft 14 includes a coupler 18 that electrically couples antenna 12 to generator 22 via power transmission cord 20.

[0026] With reference to FIGS. 3, 4 and 5, shaft 14 of antenna 12 includes a dielectric material 23 surrounding at least a portion of a length of inner conductor 16, and outer conductor 24 surrounding at least a portion of a length of dielectric material 23 and/or inner conductor 16. A pair of cables 30a, 30b extends adjacent outer conductor 24 of shaft 14. Additionally, an outer sheath 25 surrounds at least a portion of shaft 14 and cables 30a, 30b. Each cable 30a, 30b extends distally from handle portion 13 to an intermediate portion 27 of shaft 14. While FIG. 3 illustrates cables 30a and 30b at a specific location within shaft 14, cables 30a and 30b may be disposed at other positions between outer conductor 24 and outer sheath 25.

[0027] As seen in FIG. 4, a proximal end of each cable 30a and 30b is coupled to opposed sides of articulation knob 11 and a distal end of each cable 30a, 30b is coupled to intermediate portion 27 of shaft 14. In a disclosed embodiment, a proximal portion 26 of shaft 14 may be made of a semi-rigid material, intermediate portion 27 of shaft 14 (e.g., inner conductor 16, outer conductor 24 and/or dielectric material 23) may be made of a flexible material, and a distal portion 28 of shaft 14 may be made of a semi-rigid material. Such a configuration allows shaft 14 to articulate, bend or flex at intermediate portion 27, e.g., to facilitate access to various areas. Any suitable materials may be used, such as those that enable shaft 14 to be used for arthroscopic applications, for instance. In some embodiments, both proximal portion 26 and distal portion 28 may be flexible to facilitate delivery through a flexible endoscope, for example.

[0028] As seen in FIGS. 4 and 5, in use, upon distal movement of first cable 30a (and/or proximal movement of second cable 30b), intermediate portion 27 of shaft 14 moves or is articulated towards the right (or in a downward direction as viewed in FIG. 5). Similarly and/or concomitantly, in use, upon distal movement of second cable 30b (and/or proximal movement of first cable 30a), intermediate portion 27 of shaft 14 moves or is articulated towards the left or an opposite direction. In so doing, shaft 14 moves from a first position, where distal portion 28 of shaft 14 is substantially aligned with a longitudinal axis A-A (see FIG. 1) defined by handle portion 13, to at least a second position where distal portion 28 of shaft 14 is disposed at an angle relative to longitudinal axis A-A.

[0029] At least a portion of cables 30a, 30b are made of a suitable flexible and/or non-extendable/compressible material, allowing shaft 14 to be articulated along a curvilinear path and/or to be introduced through a scope (e.g., bronchoscope, colonoscope, etc.). Each cable 30a, 30b is made of a suitable non-conductive material. While a pair of cables 30a, 30b is shown in various figures herein, microwave ablation device 10 may include a single cable 30 for articulating shaft 14 in a single direction. Alternatively, microwave ablation device 10 may include more than two cables (e.g., four cables) for articulating shaft 14.

[0030] As seen in FIGS. 1 and 4, an example of a suitable articulation knob 11 is shown, for use in moving cables 30a, 30b, and thus for articulating shaft 14. As described above, a proximal end of each cable 30a, 30b is connected to or otherwise operatively secured to opposed sides of articulation knob 11. Accordingly, in use, as articulation knob 11 is rotated or pivoted about pivot 15 (as indicated by arrows “B”), cables 30a, 30b are caused to be translated distally or proximally, thus resulting in a desired direction of articulation of intermediate portion 27 of shaft 14, and thus a desired articulation and/or path of distal tip 17 of inner conductor 16. The amount of rotation of articulation knob 11 and thus axial translation of a particular cable 30a, 30b may correspond to an amount of articulation of shaft 14. In this manner, a profile of inner conductor 16 may be manipulated toward a desired treatment site (e.g., tumor 110 in FIG. 5) or to substantially surround the treatment site, for instance. In lieu of articulation knob 11, each cable 30a and 30b may be independently translatable, e.g., via a pair of articulation knobs, joysticks or slides supported on handle portion 13. Alternatively, the movement of cables 30a, 30b may be controlled electronically and/or remotely in any suitable manner.

[0031] Referring back to FIG. 1, actuation element 7 is shown disposed in mechanical cooperation with handle portion 13 and coupled (not shown) to inner conductor 16. As can be appreciated, distal and proximal translation of actuation element 7 with respect to handle portion 13 causes corresponding translation of inner conductor 16 for deployment from and/or retraction into shaft 14. Further, inner conductor 16 may be translatable with respect to outer conductor 24 and dielectric material 23.

[0032] In a disclosed embodiment, the connection between actuation element 7 and inner conductor 16 also enables rotation of shaft 14 (as indicated by arrow “C” of FIG. 1) with respect to handle portion 13, e.g., via rotation knob 9.

[0033] In accordance with an embodiment of the present disclosure, the connection between rotation knob 9 and shaft 14 allows shaft 14 to be rotated substantially about longitudinal axis A-A. Additionally, and with reference to FIGS. 1 and 4, rotation of shaft 14 and articulation of shaft 14 may be controlled independently.

[0034] As can be appreciated, the combination of the rotational and the articulation capabilities of device 10 allows shaft 14 and distal tip 17 of inner conductor 16 to be positioned at a multitude of positions adjacent and/or at least partially surrounding a desired tissue region. Accordingly, microwave ablation device 10 provides a great deal of versatility during laparoscopic, endoscopic, endoluminal, and transluminal procedures. As mentioned previously, device 10 may be capable of delivering any suitable energy, such as radiofrequency (RF), microwave (MW), laser, ultrasound and cryotherapy energy. In some embodiments, the ablative properties of device 10 may be enhanced by delivery of fluids (e.g., alcohol or chemotherapeutic agents, etc.) to the treatment site.

[0035] Microwave ablation device 10 may be introduced to the treatment site via a straight, arcuate, non-deployable and/or deployable applicator and/or introducer.

[0036] Conductors 16 and 24 may be made of a suitable conductive metal that may be semi-rigid or flexible, such as, for example, copper, gold, or other conductive metals with similar conductivity values. Alternatively, portions of conductors 16 and 24 may also be made from stainless steel, which may additionally be plated with other materials, e.g., other conductive materials, to improve their properties, e.g., to improve conductivity or decrease energy loss, etc.

[0037] For example, an inner conductor 16 made of stainless steel may have an impedance of about 50Ω. In order to improve a conductivity of stainless steel inner conductor 16, inner conductor 16 may be coated with a layer of a conductive material such as copper or gold. Although stainless steel may not offer the same conductivity as other metals, it does offer increased strength that is helpful to puncture tissue and/or skin 112 (FIG. 5).

[0038] Dielectric material 23, interposed between inner and outer conductors 16, 24, respectively, provides insulation therebetween and may be comprised of any suitable variety of conventional dielectric and/or insulative material.

[0039] FIGS. 6 and 7 show longitudinal and transverse cross-sectional views, respectively, of a variation of a shaft 14′ having conductive layers plated onto surfaces thereof to increase energy transmission and the like, according to an embodiment of the present disclosure. As shown, the outer surface of inner conductor 116 may be plated with a layer 117 of at least one additional conductive material, as described above. Likewise, the inner surface of outer conductor 124 may be similarly plated with a layer 125, that may be made of the same, similar, or different conductive material as layer 117. The addition of conductive layers 117 and/or 125 may increase energy transmission, aid in decreasing cable losses, in decreasing cable heating, and in distributing the overall temperature within the cable.

[0040] A method of treating tissue, using ablation device 10, is also included by the present disclosure. The method may include at least providing ablation device 10, such as described above, and moving at least one of cables 30a, 30b such that distal portion 28 of shaft 14 is substantially aligned with longitudinal axis A-A, to at least a second position where distal portion 28 of shaft 14 is disposed at an angle relative to longitudinal axis A-A.

[0041] An ablation system for ablating tissue is also included by the present disclosure. The ablation system includes an ablation device 10, such as described above, where an intermediate portion of antenna 12 (or other suitable energy applicator, such as an electrode) is movable from a first position where the distal tip of antenna 12 is substantially aligned with the longitudinal axis to at least a second position where the distal tip of antenna 12 is disposed at an angle to the longitudinal axis.

[0042] Various modifications may be made to the embodiments disclosed herein. Therefore, the above description should not be construed as limiting, but merely as exemplifications of various embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.

Claims

The invention claimed is:

1. An ablation device, comprising:

a handle portion;

a shaft extending distally from the handle portion, the shaft including:

an inner conductor including a length, a proximal portion and a distal tip; and

an outer conductor substantially surrounding the inner conductor at least partially along the length thereof and defining a longitudinal axis;

at least one cable extending from the handle portion along at least a portion of a length of the shaft;

wherein the inner conductor is axially translatable with respect to the outer conductor such that at least the distal tip of the inner conductor is positionable distally beyond a distal-most end of the outer conductor; and

wherein, in response to movement of the at least one cable relative to the handle portion, a distal tip of the outer conductor is movable from a first position wherein the distal tip is substantially aligned with the longitudinal axis to at least a second position wherein the distal tip is disposed at an angle relative to the longitudinal axis.

2. The ablation device according to claim 1, further including a dielectric material interposed between the inner conductor and the outer conductor.

3. The ablation device according to claim 1, further including at least a second cable extending from the handle portion along at least a portion of a length of the shaft, wherein, in response to movement of the second cable relative to the shaft, the distal tip of the outer conductor is movable from the first position to the second position.

4. The ablation device according to claim 3, wherein the first cable and the second cable are independently moveable relative to one another.

5. The ablation device according to claim 3, further including an articulation knob disposed on the handle portion, and wherein a proximal portion of the first cable is operably connected to the articulation knob and a proximal portion of the second cable is operably connected to the articulation knob, wherein movement of the articulation knob causes at least one of first and second cables to move.

6. The ablation device according to claim 1, wherein the shaft is rotatable with respect to the handle portion along the longitudinal axis.

7. The ablation device according to claim 1, wherein the distal tip of the inner conductor is movable along a curvilinear path.

8. The ablation device according to claim 1, wherein the inner conductor is configured to extend distally beyond the distal-most end of the outer conductor to at least partially surround at least a portion of tissue to be treated.

9. The ablation device according to claim 1, wherein at least a portion of the inner conductor is advanceable substantially along the longitudinal axis with respect to the outer conductor.

10. The ablation device according to claim 1, wherein at least a portion of the shaft is flexible.

11. The ablation device according to claim 1, further including an articulation knob disposed on the handle portion, and wherein a proximal portion of the at least one cable is operably connected to the articulation knob, wherein movement of the articulation knob causes corresponding movement of the at least one cable.

12. A method of treating tissue, comprising:

providing an ablation device, including:

an antenna including:

an inner conductor including a length; and

an outer conductor substantially surrounding the inner conductor at least partially along the length thereof and defining a longitudinal axis; and

at least one cable extending along a portion of the antenna;

introducing the antenna such that at least a distal tip of the inner conductor is adjacent a target site;

axially translating at least a portion of the inner conductor with respect to the outer conductor such that at least the distal tip of the inner conductor is positioned distally beyond a distal-most end of the outer conductor; and

moving the at least one cable such that a distal tip of the outer conductor moves from a first position wherein the distal tip is substantially aligned with the longitudinal axis to at least a second position wherein the distal tip is disposed at an angle relative to the longitudinal axis.

13. The method of claim 12, wherein the antenna is a coaxial cable.

14. The method of claim 12, further including rotating the antenna about the longitudinal axis.

15. The method of claim 12, wherein at least a portion of the antenna is made of a flexible material.

16. The method of claim 15, further including providing a second cable operably connected adjacent the portion of the antenna made of a flexible material.

17. The method of claim 12, wherein the antenna includes an inner conductor and an outer conductor, the inner conductor being movable with respect to the outer conductor.

18. The method of claim 17, further including the step of moving the inner conductor with respect to the outer conductor such that a distal tip of the inner conductor extends distally beyond a distal tip of the outer conductor.

19. The method of claim 18, further including the step of moving the distal tip of the inner conductor along a curvilinear path.

Patent Citations (140)

Patent	Date	Inventor	Cited By
US3631363(A)	1971-12-01	Miller	Applicant
US4397313(A)	1983-08-01	Vaguine	Applicant
US4462412(A)	1984-07-01	Turner	Applicant
US4572190(A)	1986-02-01	Azam et al.	Applicant
US4798215(A)	1989-01-01	Turner	Applicant
US5011483(A)	1991-04-01	Sleister	Applicant
US5097844(A)	1992-03-01	Turner	Applicant
US5314466(A)	1994-05-01	Stern et al.	Applicant
US5417210(A)	1995-05-01	Funda et al.	Applicant
US5500012(A)	1996-03-01	Brucker et al.	Applicant
US5569242(A)	1996-10-01	Lax et al.	Applicant
US5849011(A)	1998-12-01	Jones et al.	Applicant
US6031375(A)	2000-02-01	Atalar et al.	Applicant
US6052607(A)	2000-04-01	Edwards et al.	Applicant
US6056744(A)	2000-05-01	Edwards	Applicant
US6375606(B1)	2002-04-01	Garibaldi et al.	Applicant
US6603994(B2)	2003-08-01	Wallace et al.	Applicant
US6622731(B2)	2003-09-01	Daniel et al.	Applicant
US6652515(B1)	2003-11-01	Maguire et al.	Applicant
US6673070(B2)	2004-01-01	Edwards et al.	Applicant
US6725080(B2)	2004-04-01	Melkent et al.	Applicant
US6997925(B2)	2006-02-01	Maguire et al.	Applicant
US7025765(B2)	2006-04-01	Balbierz et al.	Applicant
US7108696(B2)	2006-09-01	Daniel et al.	Applicant
US7160296(B2)	2007-01-01	Pearson et al.	Applicant
US7278991(B2)	2007-10-01	Morris et al.	Applicant
US7344533(B2)	2008-03-01	Pearson et al.	Applicant
US7377906(B2)	2008-05-01	Selkee	Examiner
US7419487(B2)	2008-09-01	Johnson et al.	Applicant
US7422586(B2)	2008-09-01	Morris et al.	Applicant
US7439736(B2)	2008-10-01	Meaney et al.	Applicant
US7467015(B2)	2008-12-01	Van der Weide	Applicant
US7565207(B2)	2009-07-01	Turner et al.	Applicant
US2002/0022836(A1)	2002-02-01	Goble et al.	Applicant
US2002/0120261(A1)	2002-08-01	Morris et al.	Applicant
US2003/0195499(A1)	2003-10-01	Prakash et al.	Applicant
US2004/0097805(A1)	2004-05-01	Verard et al.	Applicant
US2004/0242992(A1)	2004-12-01	Hareyama	Applicant
US2005/0010095(A1)	2005-01-01	Stewart et al.	Applicant
US2005/0137662(A1)	2005-06-01	Morris et al.	Applicant
US2006/0015162(A1)	2006-01-01	Edward et al.	Applicant
US2007/0203480(A1)	2007-08-01	Mody et al.	Examiner
US2007/0255276(A1)	2007-11-01	Sliwa, Jr. et al.	Applicant
US2007/0282324(A1)	2007-12-01	Vaska et al.	Applicant
US2007/0293854(A1)	2007-12-01	Pless et al.	Applicant
US2007/0293855(A1)	2007-12-01	Sliwa, Jr. et al.	Applicant
DE390937	1924-03-01		Applicant
DE1099658	1961-02-01		Applicant
DE1139927	1962-11-01		Applicant
DE1149832	1963-06-01		Applicant
DE1439302	1969-01-01		Applicant
DE2439587	1975-02-01		Applicant
DE2455174	1975-05-01		Applicant
DE2407559	1975-08-01		Applicant
DE2415263	1975-10-01		Applicant
DE2429021	1976-01-01		Applicant
DE2460481	1976-06-01		Applicant
DE2602517	1976-07-01		Applicant
DE2504280	1976-08-01		Applicant
DE2627679	1977-01-01		Applicant
DE2540968	1977-03-01		Applicant
DE2820908	1978-11-01		Applicant
DE2803275	1979-08-01		Applicant
DE2823291	1979-11-01		Applicant
DE2946728	1981-05-01		Applicant
DE3143421	1982-05-01		Applicant
DE3045996	1982-07-01		Applicant
DE3120102	1982-12-01		Applicant
DE3510586	1986-10-01		Applicant
DE3604823	1987-08-01		Applicant
DE8712328	1988-03-01		Applicant
DE3711511	1988-06-01		Applicant
DE3904558	1990-08-01		Applicant
DE3942998	1991-07-01		Applicant
DE4238263	1993-05-01		Applicant
DE4303882	1994-08-01		Applicant
DE4339049	1995-05-01		Applicant
DE29616210	1997-01-01		Applicant
DE19608716	1997-04-01		Applicant
DE19751106	1998-05-01		Applicant
DE19717411	1998-11-01		Applicant
DE19751108	1999-05-01		Applicant
DE19801173	1999-07-01		Applicant
DE19848540	2000-05-01		Applicant
DE10224154	2003-12-01		Applicant
DE10328514	2005-03-01		Applicant
DE102004022206	2005-12-01		Applicant
DE202005015147	2006-03-01		Applicant
EP246350	1987-11-01		Applicant
EP481685	1992-04-01		Applicant
EP521264	1993-01-01		Applicant
EP541930	1993-05-01		Applicant
EP556705	1993-08-01		Applicant
EP558429	1993-09-01		Applicant
EP572131	1993-12-01		Applicant
EP836868	1998-04-01		Applicant
EP1159926	2001-05-01		Applicant
EP1186274	2002-03-01		Applicant
EP1278007	2003-01-01		Applicant
EP1656900	2006-05-01		Applicant
EP1810627	2007-07-01		Applicant
FR179607	1906-11-01		Applicant
FR1275415	1960-09-01		Applicant
FR1347865	1963-11-01		Applicant
FR2276027	1974-06-01		Applicant
FR2235669	1975-01-01		Applicant
FR2313708	1976-12-01		Applicant
FR2502935	1982-10-01		Applicant
FR2517953	1983-06-01		Applicant
FR2573301	1984-11-01		Applicant
FR2862813	2005-05-01		Applicant
FR2864439	2005-07-01		Applicant
JP5-5106	1993-01-01		Applicant
JP5-40112	1993-02-01		Applicant
JP6343644	1994-12-01		Applicant
JP7265328	1995-10-01		Applicant
JP8056955	1996-03-01		Applicant
JP8252263	1996-10-01		Applicant
JP9010223	1997-01-01		Applicant
JP11244298	1999-09-01		Applicant
JP2000342599	2000-12-01		Applicant
JP2000350732	2000-12-01		Applicant
JP2001008944	2001-01-01		Applicant
JP2001029356	2001-02-01		Applicant
JP2001128990	2001-05-01		Applicant
SU166452	1964-11-01		Applicant
SU401367	1974-11-01		Applicant
SU727201	1980-04-01		Applicant
WO93/20767	1993-10-01		Applicant
WO94/04220	1994-03-01		Applicant
WO97/41924	1997-11-01		Applicant
WO97/43971	1997-11-01		Applicant
WO/48672	2000-08-01		Applicant
WO/51513	2000-09-01		Applicant
WO1/01847	2001-01-01		Applicant
WO1/74252	2001-10-01		Applicant
WO2/45790	2002-06-01		Applicant
WO2/061880	2002-08-01		Applicant
WO2004/112628	2004-12-01		Applicant
WO2005/016119	2005-02-01		Applicant

Non-Patent Literature (267)

Esterline Product Literature, “Light Key: Visualize a Virtual Keyboard. One With No Moving Parts”, Nov. 1, 2003; 4 pages.Applicant
H. Schwarzmaier et al., “Magnetic Resonance Imaging of Microwave Induced Tissue Heating” Dept. of Laser Medicine & Dept. of Diagnostic Radiology; Heinrich-Heine-University, Duesseldorf, Germany; Dec. 8, 1994; pp. 729-731.Applicant
European Search Report EP 08011282 dated Aug. 14, 2009.Applicant
European Search Report EP 04778192.7 dated Jul. 1, 2009.Applicant
European Search Report EP 05810523 dated Jan. 29, 2009.Applicant
European Search Report EP 08011705 dated Aug. 20, 2009.Applicant
European Search Report EP 08012829.1 dated Oct. 29, 2008.Applicant
European Search Report EP 08019920.1 dated Mar. 27, 2009.Applicant
European Search Report EP 08169973.8 dated Apr. 6, 2009.Applicant
European Search Report EP 09156861.8 dated Aug. 4, 2009.Applicant
European Search Report EP 09161502.1 dated Sep. 2, 2009.Applicant
European Search Report EP 09166708 dated Oct. 15, 2009.Applicant
International Search Report PCT/US05/36168 dated Aug. 28, 2006.Applicant
International Search Report PCT/US08/052460 dated Apr. 24, 2008.Applicant
International Search Report PCT/US09/31658 dated Mar. 11, 2009.Applicant
U.S. Appl. No. 08/483,742, filed Jun. 7, 1995.Applicant
U.S. Appl. No. 08/136,098, filed Oct. 14, 1993.Applicant
U.S. Appl. No. 09/195,118, filed Nov. 18, 1998.Applicant
U.S. Appl. No. 10/244,346, filed Sep. 16, 2002.Applicant
U.S. Appl. No. 11/053,987, filed Feb. 8, 2005.Applicant
U.S. Appl. No. 12/023,606, filed Jan. 31, 2008.Applicant
U.S. Appl. No. 12/129,482, filed May 29, 2008.Applicant
U.S. Appl. No. 12/135,425, filed Jun. 9, 2008.Applicant
U.S. Appl. No. 12/135,690, filed Jun. 9, 2008.Applicant
U.S. Appl. No. 12/147,093, filed Jun. 26, 2008.Applicant
U.S. Appl. No. 12/181,504, filed Jul. 29, 2008.Applicant
U.S. Appl. No. 12/184,556, filed Aug. 1, 2008.Applicant
U.S. Appl. No. 12/194,254, filed Aug. 19, 2008.Applicant
U.S. Appl. No. 12/197,601, filed Aug. 25, 2008.Applicant
U.S. Appl. No. 12/197,405, filed Aug. 25, 2008.Applicant
U.S. Appl. No. 12/197,473, filed Aug. 25, 2008.Applicant
U.S. Appl. No. 12/199,935, filed Aug. 28, 2008.Applicant
U.S. Appl. No. 12/203,474, filed Sep. 3, 2008.Applicant
U.S. Appl. No. 12/236,686, filed Sep. 24, 2008.Applicant
U.S. Appl. No. 12/244,850, filed Oct. 3, 2008.Applicant
U.S. Appl. No. 12/250,110, filed Oct. 13, 2008.Applicant
U.S. Appl. No. 12/250,171, filed Oct. 13, 2008.Applicant
U.S. Appl. No. 12/253,457, filed Oct. 17, 2008.Applicant
U.S. Appl. No. 12/277,951, filed Nov. 25, 2008.Applicant
U.S. Appl. No. 12/350,292, filed Jan. 8, 2009.Applicant
U.S. Appl. No. 12/351,633, filed Jan. 9, 2009.Applicant
U.S. Appl. No. 12/353,623, filed Jan. 14, 2009.Applicant
U.S. Appl. No. 12/353,617, filed Jan. 14, 2009.Applicant
U.S. Appl. No. 12/356,650, filed Jan. 21, 2009.Applicant
U.S. Appl. No. 12/366,298, filed Feb. 5, 2009.Applicant
U.S. Appl. No. 12/389,906, filed Feb. 20, 2009.Applicant
U.S. Appl. No. 12/389,915, filed Feb. 20, 2009.Applicant
U.S. Appl. No. 12/395,034, filed Feb. 27, 2009.Applicant
U.S. Appl. No. 12/399,222, filed Mar. 6, 2009.Applicant
U.S. Appl. No. 12/401,268, filed Mar. 10, 2009.Applicant
U.S. Appl. No. 12/413,011, filed Mar. 27, 2009.Applicant
U.S. Appl. No. 12/413,023, filed Mar. 27, 2009.Applicant
U.S. Appl. No. 12/416,583, filed Apr. 1, 2009.Applicant
U.S. Appl. No. 12/419,395, filed Apr. 7, 2009.Applicant
U.S. Appl. No. 12/423,609, filed Apr. 14, 2009.Applicant
U.S. Appl. No. 12/434,903, filed May 4, 2009.Applicant
U.S. Appl. No. 12/436,237, filed May 6, 2009.Applicant
U.S. Appl. No. 12/436,239, filed May 6, 2009.Applicant
U.S. Appl. No. 12/436,231, filed May 6, 2009.Applicant
U.S. Appl. No. 12/472,831, filed May 27, 2009.Applicant
U.S. Appl. No. 12/475,082, filed May 29, 2009.Applicant
U.S. Appl. No. 12/476,960, filed Jun. 2, 2009.Applicant
Alexander et al., “Magnetic Resonance Image-Directed Stereotactic Neurosurgery: Use of Image Fusion with Computerized Tomography to Enhance Spatial Accuracy” Journal Neurosurgery, 83 (1995), pp. 271-276.Applicant
Anderson et al., “A Numerical Study of Rapid Heating for High Temperature Radio Frequency Hyperthermia” International Journal of Bio-Medical Computing, 35 (1994), pp. 297-307.Applicant
Anonymous. (1999) Auto Suture MIBB Site Marker: Single Use Clip Applier, United States Surgical (Product instructions), 2 pages.Applicant
Anonymous. (2001) Disposable Chiba Biopsy Needles and Trays, Biopsy and Special Purpose Needles Cook Diagnostic and Interventional Products Catalog (products list), 4 pages.Applicant
Anonymous. (1987) Homer Mammalok™ Breast Lesion Needle/Wire Localizer, Namic ® Angiographic Systems Division, Glens Falls, New York, (Hospital products price list), 4 pages.Applicant
Anonymous. (1999) MIBB Site Marker, United States Surgical (Sales brochure), 4 pages.Applicant
Anonymous. Blunt Tubes with Finished Ends. Pointed Cannula, Popper & Sons Biomedical Instrument Division, (Products Price List), one page, Jul. 19, 2000.Applicant
Anonymous. Ground Cannulae, ISPG, New Milford, CT, (Advertisement) one page, Jul. 19, 2000.Applicant
B. Levy M.D. et al., “Update on Hysterectomy New Technologies and Techniques” OBG Management, Feb. 2003.Applicant
B. Levy M.D., “Use of a New Vessel Ligation Device During Vaginal Hysterectomy” FIGO 2000, Washington, D.C.Applicant
B. Levy M.D. et al., “Randomized Trial of Suture Versus Electrosurgical Bipolar Vessel Sealing in Vaginal Hysterectomy” Obstetrics & Gynecology, vol. 102, No. 1, Jul. 2003.Applicant
B. F. Mullan et al., (May 1999) “Lung Nodules: Improved Wire for CT-Guided Localization,” Radiology 211:561-565.Applicant
B. T. Heniford M.D. et al., “Initial Research and Clinical Results with an Electrothermal Bipolar Vessel Sealer” Oct. 1999.Applicant
Bergdahl et al., “Studies on Coagulation and the Development of an Automatic Computerized Bipolar Coagulator” Journal of Neurosurgery 75:1 (Jul. 1991), pp. 148-151.Applicant
Bulletin of the American Physical Society, vol. 47, No. 5, Aug. 2002, p. 41.Applicant
C. F. Gottlieb et al., “Interstitial Microwave Hyperthermia Applicators having Submillimetre Diameters”, Int. J. Hyperthermia, vol. 6, No. 3, pp. 707-714, 1990.Applicant
C. H. Durney et al., “Antennas for Medical Applications”, Antenna Handbook: Theory Application and Design, p. 24-40, Van Nostrand Reinhold, 1988 New York, V.T. Lo, S.W. Lee.Applicant
Carbonell et al., “Comparison of the Gyrus PlasmaKinetic Sealer and the Valleylab LigaSure™ Device in the Hemostasis of Small, Medium, and Large-Sized Arteries” Carolinas Laparoscopic and Advanced Surgery Program, Carolinas Medical Center, Charlotte, NC 2003.Applicant
Carus et al., “Initial Experience With the LigaSure™ Vessel Sealing System in Abdominal Surgery” Innovations That Work, Jun. 2002.Applicant
Chicharo et al., “A Sliding Goertzel Algorithm” Aug. 1996 DOS pp. 283-297 Signal Processing, Elsevier Science Publishers B.V. Amsterdam, NL, vol. 52, No. 3.Applicant
Chou, C.K., (1995) “Radiofrequency Hyperthermia in Cancer Therapy,” Chapter 941n Biologic Effects of Nonionizing Electromagnetic Fields, CRC Press, Inc., pp. 1424-1428.Applicant
Chung et al., “Clinical Experience of Sutureless Closed Hemorrhoidectomy with LigaSure™” Diseases of the Colon & Rectum, vol. 46, No. 1, Jan. 2003.Applicant
Cosman et al., “Radiofrequency Lesion Generation and its Effect on Tissue Impedence”, Applied Neurophysiology, 51:230-242, 1988.Applicant
Cosman et al., “Theoretical Aspects of Radiofrequency Lesions in the Dorsal Root Entry Zone” Neurosurgery 15:(1984), pp. 945-950.Applicant
Cosman et al., “Methods of Making Nervous System Lesions” In William RH, Rengachary SS (eds): Neurosurgery, New York: McGraw-Hill, vol. 111, (1984), pp. 2490-2499.Applicant
Crawford et al., “Use of the LigaSure™ Vessel Sealing System in Urologic Cancer Surger” Grand Rounds in Urology 1999, vol. 1, Issue 4, pp. 10-17.Applicant
Dulemba et al., “Use of a Bipolar Electrothermal Vessel Sealer in Laparoscopically Assisted Vaginal Hysterectomy” Sales/Product Literature; Jan. 2004.Applicant
E. David Crawford, “Evaluation of a New Vessel Sealing Device in Urologic Cancer Surgery” Sales/Product Literature 2000.Applicant
E. David Crawford, “Use of a Novel Vessel Sealing Technology in Management of the Dorsal Veinous Complex” Sales/Product Literature 2000.Applicant
Esterline Product Literature, “Light Key: Visualize a Virtual Keyboard. One With No Moving Parts”, 4 pages.Applicant
Esterline, “Light Key Projection Keyboard” 2004 Advanced Input Systems, located at: <http://www.advanced-input.com/lightkey> last visited on Feb. 10, 2005.Applicant
Geddes et al., “The Measurement of Physiologic Events by Electrical Impedence” Am. J. MI, Jan. Mar. 1964, pp. 16-27.Applicant
Goldberg et al., “Image-guided Radiofrequency Tumor Ablation: Challenges and Opportunities—Part I”, (2001) J Vasc. Interv. Radiol, vol. 12, pp. 1021-1032.Applicant
Goldberg et al., “Tissue Ablation with Radiofrequency: Effect of Probe Size, Gauge, Duration, and Temperature on Lesion Volume” Acad Radio (1995) vol. 2, No. 5, pp. 399-404.Applicant
Heniford et al., “Initial Results with an Electrothermal Bipolar Vessel Sealer” Surgical Endoscopy (2001) 15:799-801.Applicant
Herman at al., “Laparoscopic Intestinal Resection With the LigaSure™ Vessel Sealing System: A Case Report” Innovations That Work, Feb. 2002.Applicant
Ian D. McRury et al., The Effect of Ablation Sequence and Duration on Lesion Shape Using Rapidly Pulsed Radiofrequency Energy Through Electrodes, Feb. 2000, Springer Netherlands, vol. 4; No. 1, pp. 307-320.Applicant
Johnson et al., “Evaluation of a Bipolar Electrothermal Vessel Sealing Device in Hemorrhoidectomy” Sales/Product Literature, Jan. 2004.Applicant
Jarrett et al., “Use of the LigaSure™ Vessel Sealing System for Peri-Hilar Vessels in Laparoscopic Nephrectomy” Sales/Product Literature 2000.Applicant
Johnson, “Evaluation of the LigaSure™ Vessel Sealing System in Hemorrhoidectormy” American College of Surgeons (ACS) Clinic La Congress Poster (2000).Applicant
Johnson, “Use of the LigaSure™ Vessel Sealing System in Bloodless Hemorrhoidectomy” Innovations That Work, Mar. 2000.Applicant
Joseph G. Andriole M.D. et al., “Biopsy Needle Characteristics Assessed in the Laboratory”, Radiology 148: 659-662, Sep. 1983.Applicant
Joseph Ortenberg, “LigaSure™ System Used in Laparoscopic 1st and 2nd Stage Orchiopexy” Innovations That Work, Nov. 2002.Applicant
K. Ogata, Modern Control Engineering, Prentice-Hall, Englewood Cliffs, N.J., 1970.Applicant
Kennedy et al., “High-burst-strength, feedback-controlled bipolar vessel sealing” Surgical Endoscopy (1998) 12: 876-878.Applicant
Kopans, D.B. et al., (Nov. 1985) “Spring Hookwire Breast Lesion Localizer: Use with Rigid-Compression. Mammographic Systems,” Radiology 157(2):537-538.Applicant
Koyle et al., “Laparoscopic Palomo Varicocele Ligation in Children and Adolescents” Pediatric Endosurgery & Innovative Techniques, vol. 6, No. 1, 2002.Applicant
LigaSure™ Vessel Sealing System, the Seal of Confidence in General , Gynecologic, Urologic, and Laparaoscopic Surgery, Sales/Product Literature, Jan. 2004.Applicant
Livraghi et al., (1995) “Saline-enhanced RF Tissue Ablation in the Treatment of Liver Metastases”, Radiology, pp. 205-210.Applicant
Lyndon B. Johnson Space Center, Houston, Texas, “Compact Directional Microwave Antenna for Localized Heating,” NASA Tech Briefs, Mar. 2008.Applicant
M. A. Astrahan, “A Localized Current Field Hyperthermia System for Use with 192-Iridium Interstitial Implants” Medical Physics. 9(3), May/Jun. 1982.Applicant
Magdy F. Iskander et al., “Design Optimization of Interstitial Antennas”, IEEE Transactions on Biomedical Engineering, vol. 36, No. 2, Feb. 1989, pp. 238-246.Applicant
McGahan et al., (1995) “Percutaneous Ultrasound-guided Radiofrequency Electrocautery Ablation of Prostate Tissue in Dogs”, Acad Radiol, vol. 2, No. 1: pp. 61-65.Applicant
McLellan et al., “Vessel Sealing for Hemostasis During Pelvic Surgery” Int'l Federation of Gynecology and Obstetrics FIGO World Congress 2000, Washington, DC.Applicant
MDTECH product literature (Mar. 2000) I'D Wire: product description, 1 page.Applicant
MDTECH product literature (Dec. 1999) “FlexStrand”: product description, 1 page.Applicant
Medtrex Brochure “The O.R. Pro 300” 1 page, Sep. 1998.Applicant
Michael Choti, “Abdominoperineal Resection with the LigaSure™ Vessel Sealing System and LigaSure™ Atlas 20 cm Open Instrument” Innovations That Work, Jun. 2003.Applicant
Muller et al., “Extended Left Hemicolectomy Using the LigaSure™ Vessel Sealing System” Innovations That Work. LJ, Sep. 1999.Applicant
Murakami, R. et al., (1995). “Treatment of Hepatocellular Carcinoma: Value of Percutaneous Microwave Coagulation,” American Journal of Radiology (AJR) 164:1159-1164.Applicant
Ni Wei et al., “A Signal Processing Method for the Coriolis Mass Flowmeter Based on a Normalized . . . ” Journal of Applied Sciences Yingyong Kexue Xuebao, Shangha CN, vol. 23, No. 2:(Mar. 2005); pp. 160-184.Applicant
Ogden, “Goertzel Alternative to the Fourier Transform” Jun. 1993 pp. 485-487 Electronics World; Reed Business Publishing, Sutton, Surrey, BG, vol. 99, No. 9, 1687.Applicant
Olsson M.D. et al., “Radical Cystectomy in Females” Current Surgical Techniques in Urology, vol. 14, Issue 3, 2001.Applicant
Organ, L W., “Electrophysiologic Principles of Radiofrequency Lesion Making” Appl. Neurophysiol, vol. 39: pp. 69-76 (1976/77).Applicant
P.R. Stauffer et al., “Interstitial Heating Technologies”, Thermoradiotheray and Thermochemotherapy (1995) vol. I, Biology, Physiology, Physics, pp. 279-320.Applicant
Palazzo et al., “Randomized clinical trial of LigaSure™ versus open haemorrhoidectomy” British Journal of Surgery 2002,89,154-157 “Innovations in Electrosurgery” Sales/Product Literature; Dec. 31, 2000.Applicant
Paul G. Horgan, “A Novel Technique for Parenchymal Division During Hepatectomy” The American Journal of Surgery, vol. 181, No. 3, Oapril 2001, pp. 236-237.Applicant
Peterson et al., “Comparison of Healing Process Following Ligation with Sutures and Bipolar Vessel Sealing” Surgical Technology International (2001).Applicant
R. Gennari et al., (Jun. 2000) “Use of Technetium-99m-Labeled Colloid Albumin for Preoperative and Intraoperative Localization of Non palpable Breast Lesions,” American College of Surgeons. 190(6):692-699.Applicant
Valleylab Brochure, “Reducing Needlestick Injuries in the Operating Room” 1 page, Mar. 2001.Applicant
Reidenbach, (1995) “First Experimental Results with Special Applicators for High-Frequency Interstitial Thermotherapy”, Society Minimally Invasive Therapy, 4(Suppl I):40 (Abstr).Applicant
Richard Wolf Medical Instruments Corp. Brochure, “Kleppinger Bipolar Forceps & Bipolar Generator” 3 pages, Jan. 1989.Applicant
Rothenberg et al., “Use of the LigaSure™ Vessel Sealing System in Minimally Invasive Surgery in Children” Int'l Pediatric Endosurgery Group (I PEG) 2000.Applicant
Sayfan et al., “Sutureless Closed Hemorrhoidectomy: A New Technique” Annals of Surgery, vol. 234, No. 1, Jul. 2001, pp. 21-24.Applicant
Sengupta et al., “Use of a Computer-Controlled Bipolar Diathermy System in Radical Prostatectomies and Other Open Urological Surgery” ANZ Journal of Surgery (2001)71.9 pp. 538-540.Applicant
Sigel et al., “The Mechanism of Blood Vessel Closure by High Frequency Electrocoagulation” Surgery Gynecology & Obstetrics, Oct. 1965 pp. 823-831.Applicant
Solbiati et al., (2001) “Percutaneous Radio-frequency Ablation of Hepatic Metastases from Colorectal Cancer: Long-term Results in 117 Patients”, Radiology, vol. 221, pp. 159-166.Applicant
Strasberg et al., “Use of a Bipolar Vassel-Sealing Device for Parenchymal Transection During Liver Surgery” Journal of Gastrointestinal Surgery, vol. 6, No. 4, Jul./Aug. 2002 pp. 569-574.Applicant
Stuart W. Young, Nuclear Magnetic Resonance Imaging—Basic Principles, Raven Press, New York, 1984.Applicant
Sugita et al., “Bipolar Coagulator with Automatic Thermocontrol” J. Neurosurg., vol. 41, Dec. 1944, pp. 777-779.Applicant
Sylvain Labonte et al., “Monopole Antennas for Microwave Catheter Ablation”, IEEE Trans. on Microwave Theory and Techniques, vol. 44, No. 10, pp. 1832-1840, Oct. 1995.Applicant
T. Matsukawa et al., “Percutaneous Microwave Coagulation Therapy in Liver Tumors”, Acta Radiologica, vol. 38, pp. 410-415, 1997.Applicant
T. Seki et al., (1994) “Ultrasonically Guided Percutaneous Microwave Coagulation Therapy for Small Hepatocellular Carcinoma,” Cancer 74(3):817-825.Applicant
S. Humphries Jr. et al., “Finite Element Codes to Model Electrical Heating and Non LInear Thermal Transport in Biological Media”, Proc. ASME HTD-355, 131 (1997).Applicant
Urologix, Inc.-Medical Professionals: Targis™ Technology (Date Unknown). “Overcoming the Challenge” located at: <http://www.urologix.com!medicaUtechnology.html > last visited on Apr. 27, 2001, 3 pages.Applicant
Urrutia et al., (1988). “Retractable-Barb Needle for Breast Lesion Localization: Use in 60 Cases,” Radiology 169(3):845-847.Applicant
Valleylab Brochure, “Valleylab Electroshield Monitoring System” 2 pages, Nov. 1995.Applicant
ValleyLab Brochure, “Electosurgery: A Historical Overview”, Innovations in Electrosurgery, 1999.Applicant
Vallfors et al., “Automatically Controlled Bipolar Electrocoagulation-‘COA-COMP’” Neurosurgical Review 7:2-3 (1984) pp. 187-190.Applicant
W. Scott Helton, “LigaSure™ Vessel Sealing System: Revolutionary Hemostasis Product for General Surgery” Sales/Product Literature 1999.Applicant
Wald et al., “Accidental Burns”, JAMA, Aug. 16, 1971, vol. 217, No. 7, pp. 916-921.Applicant
Walt Boyles, “Instrumentation Reference Book”, 2002, Butterworth-Heinemann, pp. 262-264.Applicant
European Search Report EP 03721482 dated Feb. 6, 2006.Applicant
European Search Report EP 04009964 dated Jul. 28, 2004.Applicant
European Search Report EP 04013772 dated Apr. 11, 2005.Applicant
European Search Report EP 04015980 dated Nov. 3, 2004.Applicant
European Search Report EP 04015981.6 dated Oct. 25, 2004.Applicant
European Search Report EP 04027314 dated Mar. 31, 2005.Applicant
European Search Report EP 04027479 dated Mar. 17, 2005.Applicant
European Search Report EP 04027705 dated Feb. 10, 2005.Applicant
European Search Report EP 04710258 dated Oct. 15, 2004.Applicant
European Search Report EP 04752343.6 dated Jul. 31, 2007.Applicant
European Search Report EP 05002027.0 dated May 12, 2005.Applicant
European Search Report EP 05002769.7 dated Jun. 19, 2006.Applicant
European Search Report EP 05013463.4 dated Oct. 7, 2005.Applicant
European Search Report EP 05013895 dated Oct. 21, 2005.Applicant
European Search Report EP 05014156.3 dated Jan. 4, 2006.Applicant
European Search Report EP 05016399 dated Jan. 13, 2006.Applicant
European Search Report EP 05017281 dated Nov. 24, 2005.Applicant
European Search Report EP 05019130.3 dated Oct. 27, 2005.Applicant
European Search Report EP 05019882 dated Feb. 16, 2006.Applicant
European Search Report EP 05020665.5 dated Feb. 27, 2006.Applicant
European Search Report EP 05020666.3 dated Feb. 27, 2006.Applicant
European Search Report EP 05021025.1 dated Mar. 13, 2006.Applicant
European Search Report EP 05021197.8 dated Feb. 20, 2006.Applicant
European Search Report EP 05021777 dated Feb. 23, 2006.Applicant
European Search Report EP 05021779.3 dated Feb. 2, 2006.Applicant
European Search Report EP 05021780.1 dated Feb. 23, 2006.Applicant
European Search Report EP 05021935 dated Jan. 27, 2006.Applicant
European Search Report EP 05021936.9 dated Feb. 6, 2006.Applicant
European Search Report EP 05021937.7 dated Jan. 23, 2006.Applicant
European Search Report EP 05021939 dated Jan. 27, 2006.Applicant
European Search Report EP 05021944.3 dated Jan. 25, 2006.Applicant
European Search Report EP 05022350.2 dated Jan. 30, 2006.Applicant
European Search Report EP 05023017.6 dated Feb. 24, 2006.Applicant
European Search Report EP 05025423.4 dated Jan. 19, 2007.Applicant
European Search Report EP 05025424 dated Jan. 30, 2007.Applicant
European Search Report EP 06000708.5 dated May 15, 2006.Applicant
European Search Report EP 06002279.5 dated Mar. 30, 2006.Applicant
European Search Report EP 06005185.1 dated May 10, 2006.Applicant
European Search Report EP 06005540 dated Sep. 24, 2007.Applicant
European Search Report EP 06006717.0 dated Aug. 11, 2006.Applicant
European Search Report EP 06006961 dated Oct. 22, 2007.Applicant
European Search Report EP 06006963 dated Jul. 25, 2006.Applicant
European Search Report EP 06008779.8 dated Jul. 13, 2006.Applicant
European Search Report EP 06009435 dated Jul. 13, 2006.Applicant
European Search Report EP 06010499.9 dated Jan. 29, 2008.Applicant
European Search Report EP 06014461.5 dated Oct. 31, 2006.Applicant
European Search Report EP 06018206.0 dated Oct. 20, 2006.Applicant
European Search Report EP 06019768 dated Jan. 17, 2007.Applicant
European Search Report EP 06020574.7 dated Oct. 2, 2007.Applicant
European Search Report EP 06020583.8 dated Feb. 7, 2007.Applicant
European Search Report EP 06020584.6 dated Feb. 1, 2007.Applicant
European Search Report EP 06020756.0 dated Feb. 16, 2007.Applicant
European Search Report EP 06022028.2 dated Feb. 13, 2007.Applicant
European Search Report EP 06023756.7 dated Feb. 21, 2008.Applicant
European Search Report EP 06024122.1 dated Apr. 16, 2007.Applicant
European Search Report EP 06024123.9 dated Mar. 6, 2007.Applicant
European Search Report EP 06025700.3 dated Apr. 12, 2007.Applicant
European Search Report EP 07000885.9 dated May 15, 2007.Applicant
European Search Report EP 07001480.8 dated Apr. 19, 2007.Applicant
European Search Report EP 07001481.6 dated May 2, 2007.Applicant
European Search Report EP 07001485.7 dated May 23, 2007.Applicant
European Search Report EP 07001488.1 dated Jun. 5, 2007.Applicant
European Search Report EP 07001489.9 dated Dec. 20, 2007.Applicant
European Search Report EP 07001491 dated Jun. 6, 2007.Applicant
European Search Report EP 07001527.6 dated May 18, 2007.Applicant
European Search Report EP 07007783.9 dated Aug. 14, 2007.Applicant
European Search Report EP 07008207.8 dated Sep. 13, 2007.Applicant
European Search Report EP 07009026.1 dated Oct. 8, 2007.Applicant
European Search Report EP 07009028 dated Jul. 16, 2007.Applicant
European Search Report EP 07009029.5 dated Jul. 20, 2007.Applicant
European Search Report EP 07009321.6 dated Aug. 28, 2007.Applicant
European Search Report EP 07009322.4 dated Jan. 14, 2008.Applicant
European Search Report EP 07010672.9 dated Oct. 16, 2007.Applicant
European Search Report EP 07010673.7 dated Oct. 5, 2007.Applicant
European Search Report EP 07013779.9 dated Oct. 26, 2007.Applicant
European Search Report EP 07015191.5 dated Jan. 23, 2007.Applicant
European Search Report EP 07015601.3 dated Jan. 4, 2007.Applicant
European Search Report EP 07015602.1 dated Dec. 20, 2007.Applicant
European Search Report EP 07018375.1 dated Jan. 8, 2008.Applicant
European Search Report EP 07018821 dated Jan. 14, 2008.Applicant
European Search Report EP 07019173.9 dated Feb. 12, 2008.Applicant
European Search Report EP 07019174.7 dated Jan. 29, 2008.Applicant
European Search Report EP 07019178.8 dated Feb. 12, 2008.Applicant
European Search Report EP 07020283.3 dated Feb. 5, 2008.Applicant
European Search Report EP 07253835.8 dated Dec. 20, 2007.Applicant
European Search Report EP 08001019 dated Sep. 23, 2008.Applicant
European Search Report EP 08004975 dated Jul. 24, 2008.Applicant
European Search Report EP 08006731.7 dated Jul. 29, 2008.Applicant
European Search Report EP 08006733 dated Jul. 7, 2008.Applicant
European Search Report EP 08006734.1 dated Aug. 18, 2008.Applicant
European Search Report EP 08006735.8 dated Jan. 8, 2009.Applicant
European Search Report EP 08015842 dated Dec. 5, 2008.Applicant
European Search Report EP 98300964.8 dated Dec. 13, 2000.Applicant
European Search Report EP 98944778 dated Nov. 7, 2000.Applicant
European Search Report EP 98958575.7 dated Oct. 29, 2002.Applicant
International Search Report PCT/US01/11218 dated Aug. 14, 2001.Applicant
International Search Report PCT/US01/11224 dated Nov. 13, 2001.Applicant
International Search Report PCT/US01/11340 dated Aug. 16, 2001.Applicant
International Search Report PCT/US01/11420 dated Oct. 16, 2001.Applicant
International Search Report PCT/US02/01890 dated Jul. 25, 2002.Applicant
International Search Report PCT/US02/11100 dated Jul. 16, 2002.Applicant
International Search Report PCT/US03/09483 dated Aug. 13, 2003.Applicant
International Search Report PCT/US03/22900 dated Dec. 2, 2003.Applicant
International Search Report PCT/US03/37110 dated Jul. 25, 2005.Applicant
International Search Report PCT/US03/37111 dated Jul. 28, 2004.Applicant
International Search Report PCT/US03/37310 dated Aug. 13, 2004.Applicant
International Search Report PCT/US04/04685 dated Aug. 27, 2004.Applicant
International Search Report PCT/US04/13273 dated Dec. 15, 2004.Applicant
International Search Report PCT/US04/15311 dated Jan. 12, 2004.Applicant
International Search Report PCT/US98/18640 dated Jan. 29, 1998.Applicant
International Search Report PCT/US98/23950 dated Jan. 14, 1998.Applicant
International Search Report PCT/US99/24869 dated Feb. 11, 2000.Applicant
European Search Report 09151736.7 dated Jun. 12, 2009.Applicant

Abstract