US 8,059,059 B2Grant

Slidable choke microwave antenna

Issue Date:2011-11-15

•7 Claims

•16 Drawing Sheets

Abstract

A microwave antenna assembly is disclosed. The antenna assembly includes a feedline having an inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof. The antenna assembly also includes a slidable outer jacket disposed about the radiating portion and the feedline. The slidable outer jacket being configured to slide about at least one of the radiating portion and the feedline from a closed configuration, in which the slidable outer jacket is mated with the trocar and a retracted configuration, in which the slidable outer jacket is retracted in a proximally exposing at least a portion the radiating portion.

Metadata

Assignee

Vivant Medical, Inc.

Inventor

Kenlyn Bonn

Application Information

Application Number:US 12/129,482

Filing Date:2008-05-29

Priority Date:2008-05-29

Art Unit:2821

Classifications

IPC:

A61B18/18H01Q1/42H01Q9/04

Patent Drawings (16 sheets)

Description

Background

[0001] 1. Technical Field

[0002] The present disclosure relates generally to microwave applicators used in tissue ablation procedures. More particularly, the present disclosure is directed to a microwave applicator having a slidable jacket that acts an electrical termination choke.

[0003] 2. Background of Related Art

[0004] Treatment of certain diseases requires destruction of malignant tissue growths (e.g., tumors). It is known that tumor cells denature at elevated temperatures that are slightly lower than temperatures injurious to surrounding healthy cells. Therefore, known treatment methods, such as hyperthermia therapy, heat tumor cells to temperatures above 41° C., while maintaining adjacent healthy cells at lower temperatures to avoid irreversible cell damage. Such methods involve applying electromagnetic radiation to heat tissue and include ablation and coagulation of tissue. In particular, microwave energy is used to coagulate and/or ablate tissue to denature or kill the cancerous cells.

[0005] Microwave energy is applied via microwave ablation antenna assemblies that penetrate tissue to reach tumors. There are several types of microwave antennas, such as monopole and dipole. In monopole and dipole antennas, microwave energy radiates perpendicularly from the axis of the conductor. A monopole antenna includes a single, elongated microwave conductor. Dipole antennas may have a coaxial construction including an inner conductor and an outer conductor separated by a dielectric portion. More specifically, dipole microwave antennas are typically long, thin inner conductors that extend along a longitudinal axis of the antenna and are surrounded by an outer conductor. In certain variations, a portion or portions of the outer conductor may be selectively removed to enhance the outward radiation of energy. This type of microwave antenna construction is typically referred to as a “leaky waveguide” or “leaky coaxial” antenna.

[0006] Conventional microwave antennas tend to have a narrow operational bandwidth, a wavelength range at which optimal operational efficiency is achieved, and hence, are incapable of consistently maintaining a predetermined impedance match between the microwave delivery system (e.g., generator, cable, etc.) and the tissue surrounding the microwave antenna. More specifically, as microwave energy is applied to tissue, the dielectric constant of the tissue immediately surrounding the microwave antenna decreases as the tissue is treated. The drop causes the wavelength of the microwave energy being applied to tissue to increase beyond the bandwidth of the antenna. As a result, there is a mismatch between the bandwidth of conventional microwave antenna and the microwave energy being applied. Thus, narrow band microwave antennas tend to detune over use hindering the effective delivery and dispersion of energy.

[0007] Various improvements have been disclosed in the art, which aid in maintaining proper tuning of the antenna during use as the tissue is treated. However, these improvements tend to compromise the structural integrity of the antennas, requiring additional enhancement and/or instrumentation instruments to facilitate insertion of the antenna intro the target treatment area.

Summary

[0008] According to one aspect of the present disclosure a microwave antenna assembly is disclosed. The antenna assembly includes a feedline having an inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof. The antenna assembly also includes a slidable outer jacket disposed about the radiating portion and the feedline. The slidable outer jacket being configured to slide about at least one of the radiating portion and the feedline from a closed configuration, in which the slidable outer jacket is mated with the trocar and a retracted configuration, in which the slidable outer jacket is retracted in a proximally exposing at least a portion the radiating portion.

[0009] According to another aspect of the present disclosure a microwave antenna assembly is disclosed. The antenna assembly includes a feedline having an inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof. The assembly also includes an inner fluid, which is disposed around the outer conductor in electro-mechanical contact therewith. The inner fluid feed member includes a plurality of fluid lumens defined therein configured to supply a fluid to the radiating portion. The assembly also includes an outer fluid feed member, which is disposed around the inner fluid feed member in electro-mechanical contact therewith. The outer fluid feed member also includes a plurality of fluid lumens defined therein configured to withdraw the fluid from the radiating portion.

[0010] A method for performing microwave ablation is also contemplated by the present disclosure. The method includes the step of providing a microwave antenna. The antenna assembly includes a feedline having all inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof. The antenna assembly also includes a slidable outer jacket disposed about the radiating portion and the feedline. The slidable outer jacket is configured to slide about at least one of the radiating portion and the feedline. The method also includes the steps of moving the slidable outer jacket into a closed configuration, in which the slidable outer jacket is mated with the trocar, inserting the microwave antenna into tissue and moving the slidable outer jacket into a retracted configuration, in which the slidable outer jacket is retracted proximally to expose at least a portion of the radiating portion.

Brief Description of the Drawings

[0011] The above and other aspects, features, and advantages of the present disclosure will become more apparent in light of the following detailed description when taken in conjunction with the accompanying drawings in which:

[0012] FIG. 1 is a schematic diagram of a microwave ablation system according to an embodiment of the present disclosure;

[0013] FIGS. 2 and 3 are perspective cross-sectional views of a microwave antenna assembly according to the present disclosure;

[0014] FIG. 4 is an enlarged, cross-sectional view of a portion of the microwave antenna assembly of FIG. 2;

[0015] FIG. 5 is a perspective, cross-sectional view of a microwave antenna assembly of FIG. 2;

[0016] FIG. 6 is an enlarged, cross-sectional view of a portion of the microwave antenna assembly of FIG. 2;

[0017] FIGS. 7-9 are enlarged, cross-sectional views of a trocar of the microwave antenna assembly of FIG. 2;

[0018] FIGS. 10A-B are perspective, cross-sectional views of a contact assembly of the microwave antenna assembly of FIG. 2;

[0019] FIGS. 11A-B are perspective views of the contact assembly of FIGS. 10A-B;

[0020] FIG. 12 is a schematic diagram of a microwave ablation system according one embodiment of the present disclosure;

[0021] FIG. 13 is a perspective, cross-sectional view of a microwave antenna assembly according to the present disclosure; and

[0022] FIGS. 14-17 are enlarged, cross-sectional views of a portion of the microwave antenna assembly of FIG. 12.

Detailed Description

[0023] Particular embodiments of the present disclosure will be described herein below with reference to the accompanying drawings. In the following description, well-known functions or constructions are not described in detail to avoid obscuring the present disclosure in unnecessary detail.

[0024] FIG. 1 shows a microwave ablation system 10 that includes a microwave antenna assembly 12 coupled to a microwave generator 14 via a flexible coaxial cable 16. In one embodiment, the generator 14 is configured to provide microwave energy at an operational frequency from about 500 MHz to about 5000 MHz.

[0025] The antenna assembly 12 includes a radiating portion 18 that is connected by a feedline 20 (or shaft) to the cable 16. More specifically, the antenna assembly 12 is coupled to the cable 16 through a connection hub 22. The connection hub 22 also includes an outlet fluid port 30 and an inlet fluid port 32 defined therein that are in fluid communication with the radiating portion 18 and the feedline 20 allowing dielectric coolant fluid 35 from the ports 30 and 32 to be dispersed and circulated around the antenna assembly 12. The ports 30 and 32 are also coupled to a supply pump 34 that, in turn, is coupled to a supply tank 36 that stores the dielectric coolant fluid 35 and maintains the fluid at a predetermined temperature.

[0026] In one embodiment, the supply tank 36 may include a coolant unit (not shown), which cools the returning coolant fluid 35 from the antenna assembly 12. Alternatively, the coolant fluid may be a coolant gas.

[0027] Assembly 12 also includes a trocar 25 having tapered end 24 that terminates, in one embodiment, at a pointed tip 26 to facilitate insertion of the trocar into tissue with minimal resistance at a distal end of the radiating portion 18. In those cases where the radiating portion 18 is inserted into a pre-existing opening, tip 26 may be rounded or flat.

[0028] FIG. 2 illustrates the radiating portion 18 of the antenna assembly 12 having a slidable outer jacket 102. The radiating portion 18 has a substantially cylindrical shape and the outer jacket 102 has a substantially tubular shape defining an inner diameter substantially similar to the outer diameter of the radiating portion 18. More specifically, the outer jacket 102 is configured to slide along the radiating portion 18 between a closed configuration and a retracted configuration. In the closed configuration, the jacket 102 is disposed at the distal end of the assembly 12 and the distal end of the jacket 102 is positioned in contact with the trocar 25 as shown in FIG. 8. In the retracted configuration, the jacket 102 is slid proximally thereby exposing the radiating portion 18 as shown in FIG. 7.

[0029] The jacket 102 may be formed from any suitable type of conductive metal that has high tensile strength and does not react with tissue when inserted therein, such as stainless steel, titanium, and other types of suitable metals. With reference to FIG. 2, the distal end of the jacket 102 includes a tapered edge 104 configured to fit into a tapered rim 105 of the trocar 25. More specifically, the tapered rim 105 has substantially the same angle as the tapered edge 104 allowing the jacket 102 to mate with the trocar 25 when the jacket 102 is in the closed configuration as shown in FIG. 8.

[0030] With reference to FIGS. 2 and 3, the radiating portion 18 includes a dipole antenna 40, which may be either balanced or unbalanced. The dipole antenna 40 is coupled to the feedline 20 that electrically connects antenna assembly 12 to the generator 14. As shown in FIG. 3, the feedline 20 includes an inner conductor 50 (e.g., a wire) surrounded by an inner insulator 52, which is then surrounded by an outer conductor 56 (e.g., a cylindrical conducting sheath). The inner and outer conductors 50 and 56 may be constructed of copper, gold, stainless steel or other conductive metals with similar conductivity properties. The metals may also be plated with other conductive materials, to improve the conductivity properties, e.g., to improve conductivity or decrease energy loss, etc. In one embodiment, the feedline 20 may be formed from a coaxial semi-rigid or flexible cable having a 0.047 inch outer diameter wire rated for 50 Ohms.

[0031] The dipole antenna 40 includes a proximal portion 42 and a distal portion 44 interconnected by a dielectric spacer (e.g., extended inner insulator 52) at a feed point 46. In one embodiment, where the antenna 40 is unbalanced, the distal portion 44 and the proximal portion 42 may be of different lengths. The proximal portion 42 is formed from the inner conductor 50 and the inner insulator 52, which are mutually extended outside the outer conductor 56, as shown best in FIG. 3. In one embodiment, in which the feedline 20 is formed from a coaxial cable, the outer conductor 56 and the inner insulator 52 may be exposed to reveal the inner conductor 50.

[0032] With continued reference to FIG. 3, the distal portion 44 includes a conductive member 45 that may be formed from any type of conductive material, such as a suitable metal (e.g., copper, stainless steel, tin, and various alloys thereof). The distal portion 44 may have a solid structure and may be formed from solid wire (e.g., 10 AWG). In another embodiment, the distal portion 44 may be formed from a hollow sleeve of an outer conductor of coaxial cable or another cylindrical conductor. The cylindrical conductor may then be filled with solder to convert the cylinder into a solid shaft or the cylinder may be left hollow. More specifically, the solder may be heated to a temperature sufficient to liquefy the solder within the cylindrical conductor (e.g., 500° F.), thereby creating a solid shaft.

[0033] In another embodiment, the proximal portion 42 may also be formed from solid wire or a cylindrical conductor filled with solder. The proximal portion 42 is thereafter coupled to the inner conductor 50. This may be accomplished by soldering the proximal portion 42 to the distal end of the inner conductor 50, such as by melting the solder of the proximal portion 42 and inserting the inner conductor 50 therein.

[0034] The distal portion 44 may be soldered to the inner conductor 50 of the proximal portion 42 to establish electromechanical contact therebetween. In one embodiment, where the distal portion 44 is formed from a hollow cylindrical conductor filled with a solder material, the distal portion 44 may be attached to the proximal portion 42 by liquefying the solder of the distal portion 44 and inserting the distal end of the inner conductor 50 therein. A portion of the distal end of the inner conductor 50 is inserted into the distal portion 44 such that a dipole feed gap “G” remains between the proximal and distal portions 42 and 44 as shown in FIG. 3. The gap “G” may be from about 1 mm to about 3 mm. The dipole feed gap “G” of the antenna is the first structure the coaxial field mode encounters upon transfer to free space. In one embodiment, the gap “G” is thereafter filled with a dielectric material to form the dielectric spacer at the feed point 46. The dielectric material may be polytetrafluoroethylene (PTFE), such as Teflon® sold by DuPont of Willmington, Del. In another embodiment, the gap “G” may be coated via a dielectric seal coating as discussed in more detail below.

[0035] Since the radiating portion 18 and the feedline 20 are directly in contact with a coolant fluid, these components of the assembly 12 must be sealed to prevent fluid seepage via a cast seal 110. This may be accomplished by applying any type of melt-processible polymers using conventional injection molding and screw extrusion techniques to form a cast seal 110 around the radiating portion 18 and the feedline 20 (See FIG. 2). The cast seal 110 may be formed from any suitable heat resistant and chemically inert polymer material such as fluorinated ethylene propylene (FEP) or polytetrafluoroethylene (PTFE), such as Teflon® sold by DuPont of Willmington, Del. In another embodiment, other suitable materials, which include silicone, epoxies, and casting resins may also be used.

[0036] In one embodiment, the cast seal 110 may be applied as shrink wrap. The polymer may be applied to the entire assembly 12, namely the feedline 20 and the radiating portion 18. The shrink wrap is then heated to seal the feedline 20 and radiating portion 18. The resulting cast seal 110 prevents any coolant fluid from penetrating into the assembly 12. In addition, the cast seal 110 is also applied at the point where the inner conductor 50 and the inner insulator 52 are extended past the outer conductor 56, thereby creating a space 53 at the feed point 46 and a space 55 between the trocar 25 and the distal portion 44 as shown in FIG. 3.

[0037] With reference to FIGS. 4-6, the assembly includes an inner fluid feed member 106 and an outer fluid feed member 108, The fluid feed members 106 and 108 have a substantially tubular shape and are formed from a conductive metal, such as copper, stainless steel, tin, and various alloys thereof. In another embodiment, the fluid feed members 106 and 108 may also be formed from other types of microwave impermeable materials, which may be dielectric materials having an outer surface thereof coated with a conductive material (e.g., metal). The conductive material coating has a thickness sufficient to prevent current leakage. More specifically, the thickness of the coating depends on the maximum skin penetration depth for the metal used in the coating at a predetermined microwave frequency.

[0038] The fluid feed member 106 is disposed around the outer conductor 56 and is in electro-mechanical contact therewith. In addition, the fluid feed member 106 extends from any point past the outer conductor 56 along the length thereof to the proximal end of the feedline 20 where the fluid feed member 106 is coupled to the connection hub 22 and is in fluid communication therewith.

[0039] The fluid feed member 106 includes one or more fluid lumens 107 defined therein as shown in FIGS. 5 and 6. The fluid lumens 107 terminate in one or more openings 109 defined at the distal end of the fluid feed member 106. If a plurality of openings 109 is included, a grille-type structure may be included at the distal end of the fluid feed member 106. The fluid lumens 107 may be drilled in the tubular structure of the fluid feed member 106. Alternatively, the fluid lumens 107 may be formed during casting of the fluid feed member 106. A plurality of openings 109 allows for lumen of coolant fluid and, in addition, minimizes and/or prevents microwave energy escaping or dissipating back up along the outer surface of the feedline 20.

[0040] The fluid feed member 108 is disposed around the fluid feed member 106 and is in electro-mechanical contact therewith. Thus, there is electrical contact continuity between the outer conductor 56 and the fluid feed members 106 and 108. The fluid feed member 108 also includes one or more fluid lumens 111 formed therein which also terminate in one or more respective openings 113 as shown in FIGS. 5 and 6.

[0041] With reference now to FIGS. 7-8, the trocar 25 has a generally conical shape and includes a base portion 27 as the base of the conical shape with the tapered rim 105 extending outward from the base portion 27 in the proximal direction. The trocar 25 also includes a tubular portion 29 disposed centrally on the base portion 27. The tubular portion 29 includes one or more openings 31 that provide for continuous fluid flow at the distal end of the radiating portion 18 as discussed in more detail below.

[0042] The trocar 25 may be formed from a variety of heat-resistant materials suitable for penetrating tissue, such as metals (e.g., stainless steel) and various thermoplastic materials, such as poletherimide, polyamide thermoplastic resins, an example of which is Ultem® sold by General Electric Co. of Fairfield, Conn. The trocar 25 may be machined from various stock rods to obtain a desired shape.

[0043] The trocar 25 is coupled to the radiating portion 18 of the antenna 40 by an inner cooling jacket 112. As shown in FIGS. 2 and 7, the cooling jacket 112 is disposed on top of the fluid feed member 106 and extends therefrom the length of the antenna 40 to the distal end of the radiating portion 18 where the cooling jacket 112 is coupled to the tubular portion 29 of the trocar 25. At least a portion of the cooling jacket 112 has an inner diameter that is larger than the outer diameter of antenna 40 thereby defining a first tubular fluid lumen 120 around the antenna 40. The cooling jacket 112 is coupled to the fluid feed member 106 to create a waterproof seal around the outer surface thereof.

[0044] A suitable material for the cooling jacket 112 has a minimal dielectric constant so that the material does not affect the electrical performance of the assembly 12 and is capable of withstanding temperatures generated during ablation at the radiating portion 18. In addition, the material is suitable to withstand fluid pressure due to the coolant supplied into the fluid lumen 120. In one embodiment, a sleeve of any suitable heat resistant polymer material, such as fluorinated ethylene propylene (FEP) or polytetrafluoroethylene (PTFE), such as Teflon® sold by DuPont of Willmington, Del. may be used. Additional adhesive may be used to attach the polymer material to the fluid feed member 106 and the tubular portion 27.

[0045] An outer cooling jacket 122 is also included in the assembly 12 as shown in FIGS. 2-7. The cooling jacket 122 is disposed around the fluid feed member 108 to form a waterproof seal thereabout and extends to the trocar 25. More specifically, the cooling jacket 122 is coupled to one of the base portion 27 or the tapered rim 105 of the trocar 25 such that there is sufficient clearance for the outer jacket 102 to mate with the trocar 25. Since the cooling jacket 122 is disposed on top of the fluid feed member 108, which has an outer diameter larger than the fluid feed member 106, the cooling jacket 122 defines a second tubular fluid lumen 124 around the cooling jacket 112. The cooling jacket 122 may be formed from similar materials as the cooling jacket 112. In one embodiment, the cooling jacket 122 may be any type of rigid tubing such as a catheter manufactured from polyimide and other types of polymers.

[0046] During operation, the dielectric coolant fluid 35 (e.g., saline, deionized water, etc.) is supplied to the assembly 12 by the pump 34 through the connection hub 22, which is in fluid communication with the fluid feed members 106 and 108. The fluid 35 enters the radiating portion 18 through the feed member 106 and flows into the first fluid lumen 120, along the inner surface of the cooling jacket 112, thereby contacting the antenna 40 and removing heat. Since the antenna 40 is sealed by the cast seal 110 the fluid comes directly into physical contact with antenna 40. As the fluid continues down the fluid lumen 120 the fluid enters the tubular portion 29 of the trocar 25. As shown in FIG. 9, the fluid 35 flows through the openings 31 which interconnect the first and second fluid lumens 120 and 124. The second fluid lumen 124 thereby serves as a flow return path into the fluid flow line 108, which is coupled to the outlet fluid port 30.

[0047] In another embodiment, the fluid flow may be reversed, and the fluid may be supplied through the fluid flow line 108 such that the fluid flows through the second fluid lumen 124 and enters into the first fluid lumen 120 through the trocar 25. The fluid 35 is then suctioned out through the fluid flow line 106. In this configuration, the fluid 35 comes in contact with the antenna 40 along the flow return path.

[0048] The above-discussed coolant system provides for circulation of dielectric coolant fluid 35 (e.g., saline, deionized water, etc.) through the entire length of the antenna assembly 12. The dielectric coolant fluid 35 removes the heat generated by the assembly 12. In addition, the dielectric coolant fluid 35 acts as a buffer for the assembly 12 and prevents near field dielectric properties of the assembly 12 from changing due to varying tissue dielectric properties. As microwave energy is applied during ablation, desiccation of the tissue around the radiating portion 18 results in a drop in tissue complex permittivity by a considerable factor (e.g., a factor of about 10). This dielectric constant (er′) drop increases the wavelength of microwave energy in the tissue, which dramatically affects the impedance of un-buffered microwave antenna assemblies, thereby mismatching the antenna assemblies from the system impedance (e.g., impedance of the cable 16 and the generator 14). The increase in wavelength also results in a power dissipation zone that is much longer in length along the assembly 12 than in cross sectional diameter. The decrease in tissue conductivity (er″) also affects the real part of the impedance of the assembly 12. The fluid dielectric buffering of the present disclosure moderates the increase in wavelength of the delivered energy and drop in conductivity of the near field, thereby reducing the change in impedance of the assembly 12. This allows for a more consistent antenna-to-system impedance match and spherical power dissipation zone despite tissue behavior.

[0049] The buffering of wavelength variation also allows for a more effective choking network. Choking is placed at a current point, or high impedance point, on the end of the proximal portion 42. With wavelength buffering in the choked wet tip, the half wavelength current pattern on the dipole radiating section is maintained, making the position of the high impedance point less variable and therefore allowing for a more effective choke network. Together, the cable cooling and the dielectric buffering allow for targeted and efficient energy delivery to the tissue to enable nearly spherical ablation zones and fast ablation times. Either saline or deionized water can be used with the assembly 12.

[0050] The slidable outer jacket 102 also provides a dual purpose. In closed configuration, the jacket 102 acts as a protective cover for the radiating portion 18. In addition, the outer jacket 102 increases the structural integrity of the assembly 12 during insertion. When the jacket 102 is in retracted configuration, the jacket 102 acts as a choke. The jacket 102 is typically disposed in the closed configuration during insertion of the assembly 12 into tissue and is slid back to expose the radiating section 18 once we target tissue is reached. Microwave energy and coolant 35 are thereafter supplied through the assembly 12 to perform the desired treatment procedure.

[0051] In the retracted configuration illustrated in FIGS. 4 and 5, the jacket 102 is slid back to a distance substantially equal to half the operating wavelength. The retractable distance of the jacket 102 may be controlled by providing corresponding lock and grooves (not explicitly shown) on the mating surfaces of the jacket 102 and the fluid feed member 108 or other types of tactile feedback or suitable indicators. The grooves guide the sliding of the jacket 102 and prevent further proximal movement thereof once the jacket 102 is fully retracted. In another embodiment, the jacket 102 may be slid to any desirable length (e.g., quarter wave).

[0052] The jacket 102 is disposed on top of at least a portion of the fluid feed member 108. More specifically, the jacket 102 is shorted (e.g., in electro-mechanical contact with) to the outer conductor 56 of the feedline 20 via a contact assembly 130 and the fluid feed members 106 and 108, which provide electrical continuity therebetween. This configuration allows the jacket 102 to act as a half wavelength choke when the jacket 102 is in the retracted configuration. In this configuration, the jacket 102 confines the microwave energy from the generator 14 to the radiating portion 18 of the assembly 12 thereby limiting the microwave energy deposition zone length along the feedline 20. Namely, a shorted choke placed at the high impedance point of the proximal portion 42 on the dipole confines antenna currents to the radiating section 18 and reduces the length while maximizing the cross sectional diameter of ablations due to nearly spherical power dissipation zones. To aid the sliding of the jacket 102, the outer surface of the fluid feed member 108 may be coated by a friction reducing material.

[0053] With reference to FIGS. 10A-11B, the assembly 12 includes a contact assembly 130 disposed on the proximal portion of the fluid feed member 108. The contact assembly 130 is disposed at a location at which the jacket 102 is always in contact therewith, e.g., the jacket 102 is continually in contact with the contact assembly 130 in either closed or retracted configuration. The contact assembly 130 includes a tubular housing 132 having stop members 134 disposed at the proximal and distal ends thereof. The tubular housing 132 is formed from a conductive metal and is disposed about the fluid feed member 108. The contact assembly 130 further includes a spring member 136 disposed between the stop members 134. The spring member 136 may also be formed from a conductive tensile material suitable for coiling, which is coupled to tubular housing 132 at either one of the ends thereof.

[0054] As shown in FIG. 11A, the tubular housing 132 may include one or more grooves 137 in the outer surface thereof. The ends of the spring member 136 may be bent and inserted into the grooves 137, which in combination with the stop members 134 prevent torsional and longitudinal displacement of the spring member 136 as shown in FIG. 11B.

[0055] As the jacket 102 is slid across the fluid feed member 108, the spring member 136 is pushed outwards due to mechanical forces and contacts the inner surface of the jacket 102 thereby maintaining an electrical connection between the outer conductor 56 and the jacket 102. In one embodiment, the spring member 136 may be coated by a conductive and/or corrosion resistant coating to facilitate sliding the jacket 102 and maintaining electrical contact therebetween. The coating may include various metal compounds such nickel, silver, and the like.

[0056] FIGS. 12-14 illustrate another embodiment of a microwave antenna assembly 112 having a radiating portion 118 and a feedline 120 that couples the assembly 112 to the cable 16. More specifically, the antenna assembly 112 is coupled to the cable 16 through a connection hub 122 that includes an outlet fluid port 130 and an inlet fluid port 132 defined therein. The assembly 112 includes a slidable outer jacket 202 configured to slide between a closed configuration and a retracted configuration. The assembly 112 further includes a trocar 125 disposed at the distal end thereof. The trocar 125 includes a tapered rim 205 that is adapted to mate with a tapered edge 204 of the jacket 202 when the jacket 202 is in closed configuration. The assembly 112 also includes the connection hub 122 having a cable connector and fluid ports 130 and 132. The cable connector 179 is coupled to the inner conductor 152 and outer conductor 156 extendes outside the outer conductor 156 at the proximal end of the feedline 120.

[0057] FIGS. 13 and 14 illustrate the radiating portion 118 of the antenna assembly 112 having a dipole antenna 140 that is enclosed by a solid dielectric loading 190. The dipole antenna 140 may be either balanced or unbalanced. The dipole antenna 140 is coupled to the feedline 120, which electrically connects antenna assembly 112 to the generator 14. As shown in FIG. 14, similar to the feedline 20, the feedline 120 includes an inner conductor 150 (e.g., wire) surrounded by an inner insulator 152 which is then surrounded by an outer conductor 156 (e.g., cylindrical conducting cooling jacket).

[0058] The dipole antenna 140 includes a proximal portion 142 and a distal portion 144 that includes a conductive member 145. The distal and proximal portions are interconnected by a dielectric spacer at a feed point 146. The proximal portion 142 is formed from the inner conductor 150 and the inner insulator 152 that are extended outside the outer conductor 156. In one embodiment, in which the feedline 120 is formed from a coaxial cable, the outer conductor 156 and the inner insulator 152 may be exposed to reveal the inner conductor 150 as shown in FIG. 14.

[0059] The distal portion 144 may be formed from any type of conductive material, such as metals (e.g., copper, stainless steel, tin, and various alloys thereof. The portion 144 may have a solid structure and may be formed from solid wire (e.g., 10 AWG) or a cylindrical conductor filled with solder similar to the portion 44 of the assembly 12. The proximal portion 144 is thereafter coupled to the inner conductor 150.

[0060] The assembly 112 includes a solid dielectric loading 190 disposed over the dipole antenna 140. The loading 190 is also coupled to the trocar 125. The loading 190 may be cylinder-shaped having a central cavity 198 defined therein suitable for insertion over the distal portion 144 of the antenna 140. The cavity 198 may have a substantially cylindrical shape suitable to fit over the antenna 140 depending on the cross-sectional shape thereof. The dielectric loading 190 is coupled to the trocar 125 at the distal end of the assembly 112.

[0061] In one embodiment, the dielectric material of the loading 190 may have a dielectric constant of from about 2.5 and 150 and may be made from a ceramic material, such as alumina ceramic or a plastic material, such as a polyamide plastic (e.g., VESPEL® available from DuPont of Wilmington, Del.). The loading 190 acts as a dielectric buffer between the radiating portion 118 and the tissue so that as the electrical properties of the tissue change during ablation the antenna assembly 112 remains halfwave resonant and impedance-matched to the energy delivery system (e.g., the generator 14, the cable 16, etc.) throughout the ablation procedure.

[0062] Since the feedline 120 is in contact with the coolant fluid 35, the feedline 120 is sealed to prevent any fluid seeping thereinto via a cast seal 210 similar to the cast seal 110. The assembly 112 also includes an inner fluid feed member 206 and an outer fluid feed member 208 as shown in FIGS. 14-16. The fluid feed members 206 and 208 have a substantially tubular shape and are formed from a conductive metal, such as copper, stainless steel, tin, and various alloys thereof or may be coated with a conductive material (e.g., metal). The fluid feed members 206 and 208 are coupled to the connection hub 122 and are configured to circulate fluid through the assembly 112. The fluid feed members 206 and 208 includes one or more fluid lumens 207 and 211, respectively, defined therein which terminate in one or more openings defined in the distal end thereof similar to the fluid feed members 106 and 108. The fluid feed member 206 is disposed around the outer conductor 156 and is in electro-mechanical contact therewith. The fluid feed member 208 is, in turn, disposed about the fluid feed member 208 with the distal end thereof terminating proximally of the distal end of the fluid feed member 206.

[0063] An outer cooling jacket 222 is included in the assembly 12 as shown in FIG. 14. The cooling jacket 222 is disposed around the fluid feed member 208 to form a waterproof seal thereabout and extends to the trocar 125, thereby enclosing the loading 190. More specifically, the cooling jacket 122 is coupled the base portion 127 or the tapered rim 205 of the trocar 125 such that there is sufficient clearance for the outer jacket 202 to mate with the trocar 125. Since the cooling jacket 222 is disposed on top of the fluid feed member 208, the cooling jacket 222 defines a fluid lumen 224 around feedline 120. The cooling jacket 222 extends to the trocar 125 and may be formed from similar materials as the cooling jackets of assembly 12.

[0064] During operation, the dielectric coolant fluid 35 (e.g., saline, deionized water, etc.) is supplied to the assembly 112 by the pump 34 through the connection hub 122, which is in fluid communication with the fluid feed members 206 and 208. Similar to the system described above, the fluid 35 flows into the fluid lumen 224 from the fluid feed member 206 thereby contacting the outer conductor 156 and removing heat. Since the outer conductor 156 is sealed by the cast seal 210, the coolant fluid 35 is not in direct physical contact therewith. The fluid 35 is withdrawn through the fluid feed member 208, thereby circulating the fluid 35 from the distal end to the proximal end of the feedline 120. In another embodiment, the fluid 35 flow may be reversed, and the fluid 35 may be supplied through the fluid flow line 208 such that the fluid flows and then suctioned out through the fluid flow line 206.

[0065] The slidable outer jacket 202 is adapted to slide along the cooling jacket 202 and the fluid feed member 208 from a closed configuration in which the slidable outer jacket 202 is mated with the trocar 125 and a retracted configuration in which the slidable outer jacket 202 is disposed a predetermined length alone the assembly 112 (e.g., half wavelength, quarter wavelength, etc.). The assembly 112 also includes a contact assembly 130 as shown in FIGS. 9-11 to provide electrical contact between the fluid feed members 206 and 208 and the sliding outer jacket 202.

[0066] The described embodiments of the present disclosure are intended to be illustrative rather than restrictive, and are not intended to represent every embodiment of the present disclosure. Various modifications and variations can be made without departing from the spirit or scope of the disclosure as set forth in the following claims both literally and in equivalents recognized in law.

Claims

What is claimed is:

1. A microwave antenna assembly comprising:

a feedline including an inner conductor, an outer conductor and an inner insulator disposed therebetween;

a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof;

a slidable outer jacket disposed about the radiating portion and the feedline, the slidable outer jacket configured to slide about at least one of the radiating portion and the feedline from a closed configuration, in which the slidable outer jacket is mated with the trocar, and a retracted configuration, in which the slidable outer jacket is retracted proximally to expose at least a portion of the radiating portion; and

a contact assembly disposed around the feedline and in electrical contact with the outer conductor, the contact assembly adapted to provide continuous electrical contact between the outer conductor and the slidable outer jacket, the contact assembly further comprising:

a tubular housing having at least two stop members each of which is disposed at a proximal distal end thereof, respectively; and

a spring member disposed about the tubular housing between the at least two stop members, the spring member adapted to bias the slidable outer jacket.

2. A microwave antenna assembly according to claim 1, wherein the tubular housing and the spring member are formed from a conductive material.

3. A microwave antenna assembly according to claim 1, wherein the spring member is coated by a conductive coating having at least one metal compound.

4. A microwave antenna assembly according to claim 1, wherein the slidable outer jacket is formed from a conductive metal.

5. A microwave antenna assembly according to claim 1, wherein the slidable outer jacket includes a tapered edge at a distal end thereof and the trocar includes a tapered tip adapted to mate with the tapered edge when the slidable outer jacket is in the closed configuration.

6. A method for performing microwave ablation, the method comprising the steps of:

providing a microwave antenna comprising:

a feedline including an inner conductor, an outer conductor and an inner insulator disposed therebetween;

a radiating portion including a dipole antenna coupled to the feedline and a trocar coupled to the dipole antenna at a distal end thereof;

a tubular housing having at least two stop members each of which is disposed at a proximal end and a distal end thereof, respectively; and

a spring member disposed about the tubular housing between the at least two stop members, the spring member adapted to bias the slidable outer jacket;

moving the slidable outer jacket into a closed configuration, in which the slidable outer jacket is mated with the trocar;

inserting the microwave antenna into tissue; and

moving the slidable outer jacket into a retracted configuration, in which the slidable outer jacket is retracted proximally to expose at least a portion of the radiating portion.

7. The method according to claim 6, further comprising the step of:

maintaining continuous electrical contact between the outer conductor and the slidable outer jacket during the moving steps.

Patent Citations (204)

Patent	Date	Inventor	Cited By
US3230957(A)	1966-01-01	Seifert	Applicant
US3631363(A)	1971-12-01	Miller	Applicant
US4557272(A)	1985-12-01	Carr	Applicant
US4612940(A)	1986-09-01	Kasevich et al.	Applicant
US4643186(A)	1987-02-01	Rosen et al.	Applicant
US4658836(A)	1987-04-01	Turner	Applicant
US4674481(A)	1987-06-01	Boddie, Jr. et al.	Applicant
US4700716(A)	1987-10-01	Kasevich et al.	Applicant
US4743725(A)	1988-05-01	Risman	Applicant
US4776086(A)	1988-10-01	Kasevich et al.	Applicant
US4798215(A)	1989-01-01	Turner	Applicant
US4800899(A)	1989-01-01	Elliott	Applicant
US4807620(A)	1989-02-01	Strul et al.	Applicant
US4817635(A)	1989-04-01	Joines et al.	Applicant
US4825880(A)	1989-05-01	Stauffer et al.	Applicant
US4841988(A)	1989-06-01	Fetter et al.	Applicant
US4934365(A)	1990-06-01	Morgenthaler	Applicant
US4945912(A)	1990-08-01	Langberg	Applicant
US5026959(A)	1991-06-01	Ito et al.	Applicant
US5057106(A)	1991-10-01	Kasevich et al.	Applicant
US5065819(A)	1991-11-01	Kasevich	Applicant
US5097845(A)	1992-03-01	Fetter et al.	Applicant
US5097846(A)	1992-03-01	Larsen	Applicant
US5129396(A)	1992-07-01	Rosen et al.	Applicant
US5190054(A)	1993-03-01	Fetter et al.	Applicant
US5246438(A)	1993-09-01	Langberg	Applicant
US5281217(A)	1994-01-01	Edwards et al.	Applicant
US5300068(A)	1994-04-01	Rosar et al.	Applicant
US5301687(A)	1994-04-01	Wong et al.	Applicant
US5330518(A)	1994-07-01	Neilson et al.	Applicant
US5344441(A)	1994-09-01	Gronauer	Applicant
US5358515(A)	1994-10-01	Hurter et al.	Applicant
US5369251(A)	1994-11-01	King et al.	Applicant
US5370644(A)	1994-12-01	Langberg	Applicant
US5405346(A)	1995-04-01	Grundy et al.	Applicant
US5549639(A)	1996-08-01	Ross	Applicant
US5658278(A)	1997-08-01	Imran et al.	Applicant
US5776176(A)	1998-07-01	Rudie	Applicant
US5861021(A)	1999-01-01	Thome et al.	Applicant
US5871523(A)	1999-02-01	Fleischman et al.	Applicant
US5871525(A)	1999-02-01	Edwards et al.	Applicant
US5904709(A)	1999-05-01	Arndt et al.	Applicant
US5938692(A)	1999-08-01	Rudie	Applicant
US5944749(A)	1999-08-01	Fenn	Applicant
US5957922(A)	1999-09-01	Imran	Applicant
US5957969(A)	1999-09-01	Warner et al.	Applicant
US5964755(A)	1999-10-01	Edwards	Applicant
US6016452(A)	2000-01-01	Kasevich	Applicant
US6019757(A)	2000-02-01	Scheldrup	Applicant
US6026331(A)	2000-02-01	Feldberg et al.	Applicant
US6134476(A)	2000-10-01	Arndt et al.	Applicant
US6210367(B1)	2001-04-01	Carr	Applicant
US6245062(B1)	2001-06-01	Berube et al.	Applicant
US6287302(B1)	2001-09-01	Berube	Applicant
US6289249(B1)	2001-09-01	Arndt et al.	Applicant
US6312427(B1)	2001-11-01	Berube et al.	Applicant
US6312428(B1)	2001-11-01	Eggers et al.	Applicant
US6325796(B1)	2001-12-01	Berube et al.	Applicant
US6364876(B1)	2002-04-01	Erb et al.	Applicant
US6383182(B1)	2002-05-01	Berube et al.	Applicant
US6398781(B1)	2002-06-01	Goble et al.	Applicant
US6440158(B1)	2002-08-01	Saab	Applicant
US6485486(B1)	2002-11-01	Trembly et al.	Applicant
US6496738(B2)	2002-12-01	Carr	Applicant
US6512956(B2)	2003-01-01	Arndt et al.	Applicant
US6527768(B2)	2003-03-01	Berube	Applicant
US6582427(B1)	2003-06-01	Goble et al.	Applicant
US6592579(B2)	2003-07-01	Arndt et al.	Applicant
US6675050(B2)	2004-01-01	Arndt et al.	Applicant
US6706040(B2)	2004-03-01	Mahon et al.	Applicant
US6823218(B2)	2004-11-01	Berube	Applicant
US6878147(B2)	2005-04-01	Prakash et al.	Applicant
US6905510(B2)	2005-06-01	Saab	Applicant
US6957108(B2)	2005-10-01	Turner et al.	Applicant
US6962586(B2)	2005-11-01	Berube et al.	Applicant
US7101369(B2)	2006-09-01	Van der Welde	Applicant
US7113832(B2)	2006-09-01	Longo	Applicant
US7118590(B1)	2006-10-01	Cronin	Applicant
US7128739(B2)	2006-10-01	Prakash et al.	Applicant
US7147632(B2)	2006-12-01	Prakash et al.	Applicant
US7180307(B2)	2007-02-01	Wakino et al.	Applicant
US7244254(B2)	2007-07-01	Brace et al.	Applicant
US7311703(B2)	2007-12-01	Turovskiy et al.	Applicant
US7318824(B2)	2008-01-01	Prakash et al.	Applicant
US7378363(B2)	2008-05-01	Zheng et al.	Applicant
US7396355(B2)	2008-07-01	Goldman et al.	Applicant
US2002/0022836(A1)	2002-02-01	Goble et al.	Applicant
US2003/0088242(A1)	2003-05-01	Prakash et al.	Examiner
US2003/0153908(A1)	2003-08-01	Goble et al.	Applicant
US2004/0254621(A1)	2004-12-01	Jones et al.	Applicant
US2005/0015081(A1)	2005-01-01	Turovskiy et al.	Examiner
US2005/0113893(A1)	2005-05-01	Saab	Applicant
US2005/0149010(A1)	2005-07-01	Turovskiy et al.	Applicant
US2005/0165389(A1)	2005-07-01	Swain et al.	Applicant
US2006/0085054(A1)	2006-04-01	Zikorus et al.	Applicant
US2006/0151485(A1)	2006-07-01	Cronin	Applicant
US2006/0241576(A1)	2006-10-01	Diederich et al.	Applicant
US2006/0259024(A1)	2006-11-01	Turovskiy et al.	Applicant
US2006/0264923(A1)	2006-11-01	Prakash et al.	Applicant
US2006/0282069(A1)	2006-12-01	Prakash et al.	Applicant
US2006/0287649(A1)	2006-12-01	Ormsby et al.	Applicant
US2006/0289528(A1)	2006-12-01	Chiu et al.	Applicant
US2006/0293650(A1)	2006-12-01	Prakash et al.	Applicant
US2006/0293651(A1)	2006-12-01	Cronin	Applicant
US2006/0293652(A1)	2006-12-01	Van der Weide	Applicant
US2007/0016181(A1)	2007-01-01	Van der Weide et al.	Applicant
US2007/0043346(A1)	2007-02-01	Cronin	Applicant
US2007/0049917(A1)	2007-03-01	Yang et al.	Applicant
US2007/0060989(A1)	2007-03-01	Deem et al.	Applicant
US2007/0185554(A1)	2007-08-01	Appling et al.	Applicant
US2007/0203551(A1)	2007-08-01	Cronin et al.	Applicant
US2007/0233057(A1)	2007-10-01	Konishi	Applicant
US2007/0282319(A1)	2007-12-01	Van der Weide et al.	Applicant
US2007/0288079(A1)	2007-12-01	Van der Weide et al.	Applicant
US2009/0131926(A1)	2009-05-01	Rusin et al.	Examiner
US2009/0248006(A1)	2009-10-01	Paulus et al.	Examiner
DE390937	1924-03-01		Applicant
DE1099658	1961-02-01		Applicant
DE1139927	1962-11-01		Applicant
DE1149832	1963-06-01		Applicant
DE1439302	1969-01-01		Applicant
DE2439587	1975-02-01		Applicant
DE2455174	1975-05-01		Applicant
DE2407559	1975-08-01		Applicant
DE2415263	1975-10-01		Applicant
DE2429021	1976-01-01		Applicant
DE2460481	1976-06-01		Applicant
DE2602517	1976-07-01		Applicant
DE2504280	1976-08-01		Applicant
DE2627679	1977-01-01		Applicant
DE2540968	1977-03-01		Applicant
DE2820908	1978-11-01		Applicant
DE2803275	1979-08-01		Applicant
DE2823291	1979-11-01		Applicant
DE2946728	1981-05-01		Applicant
DE3143421	1982-05-01		Applicant
DE3045996	1982-07-01		Applicant
DE3120102	1982-12-01		Applicant
DE3510586	1986-10-01		Applicant
DE3604823	1987-08-01		Applicant
DE8712328	1988-03-01		Applicant
DE3711511	1988-06-01		Applicant
DE3904558	1990-08-01		Applicant
DE3942998	1991-07-01		Applicant
DE4238263	1993-05-01		Applicant
DE4303882	1994-08-01		Applicant
DE4339049	1995-05-01		Applicant
DE29616210	1997-01-01		Applicant
DE19608716	1997-04-01		Applicant
DE19751106	1998-05-01		Applicant
DE19717411	1998-11-01		Applicant
DE19751108	1999-05-01		Applicant
DE19801173	1999-07-01		Applicant
DE19848540	2000-05-01		Applicant
DE10224154	2003-12-01		Applicant
DE10328514	2005-03-01		Applicant
DE102004022206	2005-12-01		Applicant
DE202005015147	2006-03-01		Applicant
EP246350	1987-11-01		Applicant
EP521264	1993-01-01		Applicant
EP556705	1993-08-01		Applicant
EP558429	1993-09-01		Applicant
EP836868	1998-04-01		Applicant
EP1055400	2000-11-01		Applicant
EP1159926	2001-05-01		Applicant
FR179607	1906-11-01		Applicant
FR1275415	1960-09-01		Applicant
FR1347865	1963-11-01		Applicant
FR2276027	1974-06-01		Applicant
FR2235669	1975-01-01		Applicant
FR2313708	1976-12-01		Applicant
FR2502935	1982-10-01		Applicant
FR2517953	1983-06-01		Applicant
FR2573301	1984-11-01		Applicant
FR2862813	2005-05-01		Applicant
FR2864439	2005-07-01		Applicant
GB2295094	1996-05-01		Applicant
GB2387544	2003-10-01		Applicant
GB2388039	2003-11-01		Applicant
GB2390545	2004-01-01		Applicant
GB2403148	2004-12-01		Applicant
GB2415630	2006-01-01		Applicant
GB2416307	2006-01-01		Applicant
JP5-5106	1993-01-01		Applicant
JP5-40112	1993-02-01		Applicant
JP6343644	1994-12-01		Applicant
JP7265328	1995-10-01		Applicant
JP8056955	1996-03-01		Applicant
JP8252263	1996-10-01		Applicant
JP9010223	1997-01-01		Applicant
JP11244298	1999-09-01		Applicant
JP2000342599	2000-12-01		Applicant
JP2000350732	2000-12-01		Applicant
JP2001008944	2001-01-01		Applicant
JP2001029356	2001-02-01		Applicant
JP2001128990	2001-05-01		Applicant
SU166452	1964-11-01		Applicant
SU401367	1974-11-01		Applicant
SU727201	1980-04-01		Applicant
WO2/061880	2002-08-01		Applicant
WO3/024309	2003-03-01		Applicant
WO2005/011049	2005-02-01		Applicant
WO2007/024878	2007-03-01		Applicant
WO2007/076924	2007-07-01		Applicant

Non-Patent Literature (286)

International Search Report PCT/US98/23950 dated Jan. 14, 1998.Applicant
International Search Report PCT/US99/24869 dated Feb. 11, 2000.Applicant
International Search Report PCT/US01/11218 dated Aug. 14, 2001.Applicant
International Search Report PCT/US01/11224 dated Nov. 13, 2001.Applicant
International Search Report PCT/US01/11340 dated Aug. 16, 2001.Applicant
International Search Report PCT/US01/11420 dated Oct. 16, 2001.Applicant
International Search Report PCT/US02/01890 dated Jul. 25, 2002.Applicant
International Search Report PCT/US02/11100 dated Jul. 16, 2002.Applicant
International Search Report PCT/US03/09483 dated Aug. 13, 2003.Applicant
International Search Report PCT/US03/22900 dated Dec. 2, 2003.Applicant
International Search Report PCT/US03/37110 dated Jul. 25, 2005.Applicant
International Search Report PCT/US03/37111 dated Jul. 28, 2004.Applicant
International Search Report PCT/US03/37310 dated Aug. 13, 2004.Applicant
International Search Report PCT/US04/04685 dated Aug. 27, 2004.Applicant
International Search Report PCT/US04/13273 dated Dec. 15, 2004.Applicant
International Search Report PCT/US04/15311 dated Jan. 12, 2004.Applicant
International Search Report PCT/US05/36168 dated Aug. 28, 2006.Applicant
International Search Report PCT/US08/052460 dated Apr. 24, 2008.Applicant
International Search Report PCT/US09/31658 dated Mar. 11, 2009.Applicant
European Search Report EP 07015601.3 dated Jan. 4, 2007.Applicant
European Search Report EP 07015602.1 dated Dec. 20, 2007.Applicant
European Search Report EP 07018375.1 dated Jan. 8, 2008.Applicant
European Search Report EP 07018821 dated Jan. 14, 2008.Applicant
European Search Report EP 07019173.9 dated Feb. 12, 2008.Applicant
European Search Report EP 07019174.7 dated Jan. 29, 2008.Applicant
European Search Report EP 07019178.8 dated Feb. 12, 2008.Applicant
European Search Report EP 07020283.3 dated Feb. 5, 2008.Applicant
European Search Report EP 07253835.8 dated Dec. 20, 2007.Applicant
European Search Report EP 08001019 dated Sep. 23, 2008.Applicant
European Search Report EP 08004975 dated Jul. 24, 2008.Applicant
European Search Report EP 08006731.7 dated Jul. 29, 2008.Applicant
European Search Report EP 08006733 dated Jul. 7, 2008.Applicant
European Search Report EP 08006734.1 dated Aug. 18, 2008.Applicant
European Search Report EP 08006735.8 dated Jan. 8, 2009.Applicant
European Search Report EP 08011282 dated Aug. 14, 2009.Applicant
European Search Report EP 08011705 dated Aug. 20, 2009.Applicant
European Search Report EP 08012829.1 dated Oct. 29, 2008.Applicant
European Search Report EP 08015842 dated Dec. 5, 2008.Applicant
European Search Report EP 08019920.1 dated Mar. 27, 2009.Applicant
European Search Report EP 08169973.8 dated Apr. 6, 2009.Applicant
European Search Report EP 09156861.8 dated Aug. 4, 2009.Applicant
European Search Report EP 09161502.1 dated Sep. 2, 2009.Applicant
European Search Report extended EP 09161502.1 dated Oct. 30, 2009.Applicant
European Search Report EP 09166708 dated Oct. 15, 2009.Applicant
International Search Report PCT/US98/18640 dated Jan. 29, 1998.Applicant
European Search Report EP 06020584.6 dated Feb. 1, 2007.Applicant
European Search Report EP 06020756.0 dated Feb. 16, 2007.Applicant
European Search Report EP 06022028.2 dated Feb. 13, 2007.Applicant
European Search Report EP 06023756.7 dated Feb. 21, 2008.Applicant
European Search Report EP 06024122.1 dated Apr. 16, 2007.Applicant
European Search Report EP 06024123.9 dated Mar. 6, 2007.Applicant
European Search Report EP 06025700.3 dated Apr. 12, 2007.Applicant
European Search Report EP 07000885.9 dated May 15, 2007.Applicant
European Search Report EP 07001480.8 dated Apr. 19, 2007.Applicant
European Search Report EP 07001481.6 dated May 2, 2007.Applicant
European Search Report EP 07001485.7 dated May 23, 2007.Applicant
European Search Report EP 07001488.1 dated Jun. 5, 2007.Applicant
European Search Report EP 07001489.9 dated Dec. 20, 2007.Applicant
European Search Report EP 07001491 dated Jun. 6, 2007.Applicant
European Search Report EP 07001527.6 dated May 18, 2007.Applicant
European Search Report EP 07007783.9 dated Aug. 14, 2007.Applicant
European Search Report EP 07008207.8 dated Sep. 13, 2007.Applicant
European Search Report EP 07009026.1 dated Oct. 8, 2007.Applicant
European Search Report EP 07009028 dated Jul. 16, 2007.Applicant
European Search Report EP 07009029.5 dated Jul. 20, 2007.Applicant
European Search Report EP 07009321.6 dated Aug. 28, 2007.Applicant
European Search Report EP 07009322.4 dated Jan. 14, 2008.Applicant
European Search Report EP 07010672.9 dated Oct. 16, 2007.Applicant
European Search Report EP 07010673.7 dated Oct. 5, 2007.Applicant
European Search Report EP 07013779.9 dated Oct. 26, 2007.Applicant
European Search Report EP 07015191.5 dated Jan. 23, 2007.Applicant
European Search Report EP 05021780.1 dated Feb. 23, 2006.Applicant
European Search Report EP 05021935 dated Jan. 27, 2006.Applicant
European Search Report EP 05021936.9 dated Feb. 6, 2006.Applicant
European Search Report EP 05021937.7 dated Jan. 23, 2006.Applicant
European Search Report EP 05021939 dated Jan. 27, 2006.Applicant
European Search Report EP 05021944.3 dated Jan. 25, 2006.Applicant
European Search Report EP 05022350.2 dated Jan. 30, 2006.Applicant
European Search Report EP 05023017.6 dated Feb. 24, 2006.Applicant
European Search Report EP 05025423.4 dated Jan. 19, 2007.Applicant
European Search Report EP 05025424 dated Jan. 30, 2007.Applicant
European Search Report EP 05810523 dated Jan. 29, 2009.Applicant
European Search Report EP 06000708.5 dated May 15, 2006.Applicant
European Search Report EP 06002279.5 dated Mar. 30, 2006.Applicant
European Search Report EP 06005185.1 dated May 10, 2006.Applicant
European Search Report EP 06005540 dated Sep. 24, 2007.Applicant
European Search Report EP 06006717.0 dated Aug. 11, 2006.Applicant
European Search Report EP 06006961 dated Oct. 22, 2007.Applicant
European Search Report EP 06006963 dated Jul. 25, 2006.Applicant
European Search Report EP 06008779.8 dated Jul. 13, 2006.Applicant
European Search Report EP 06009435 dated Jul. 13, 2006.Applicant
European Search Report EP 06010499.9 dated Jan. 29, 2008.Applicant
European Search Report EP 06014461.5 dated Oct. 31, 2006.Applicant
European Search Report EP 06018206.0 dated Oct. 20, 2006.Applicant
European Search Report EP 06019768 dated Jan. 17, 2007.Applicant
European Search Report EP 06020574.7 dated Oct. 2, 2007.Applicant
European Search Report EP 06020583.8 dated Feb. 7, 2007.Applicant
European Search Report EP 03721482 dated Feb. 6, 2006.Applicant
European Search Report EP 04009964 dated Jul. 28, 2004.Applicant
European Search Report EP 04013772 dated Apr. 11, 2005.Applicant
European Search Report EP 04015980 dated Nov. 3, 2004.Applicant
European Search Report EP 04015981.6 dated Oct. 25, 2004.Applicant
European Search Report EP 04027314 dated Mar. 31, 2005.Applicant
European Search Report EP 04027479 dated Mar. 17, 2005.Applicant
European Search Report EP 04027705 dated Feb. 10, 2005.Applicant
European Search Report EP 04710258 dated Oct. 15, 2004.Applicant
European Search Report EP 04752343.6 dated Jul. 31, 2007.Applicant
European Search Report EP 04778192.7 dated Jul. 1, 2009.Applicant
European Search Report EP 05002027.0 dated May 12, 2005.Applicant
European Search Report EP 05002769.7 dated Jun. 19, 2006.Applicant
European Search Report EP 05013463.4 dated Oct. 7, 2005.Applicant
European Search Report EP 05013895 dated Oct. 21, 2005.Applicant
European Search Report EP 05014156.3 dated Jan. 4, 2006.Applicant
European Search Report EP 05016399 dated Jan. 13, 2006.Applicant
European Search Report EP 05017281 dated Nov. 24, 2005.Applicant
European Search Report EP 05019130.3 dated Oct. 27, 2005.Applicant
European Search Report EP 05019882 dated Feb. 16, 2006.Applicant
European Search Report EP 05020665.5 dated Feb. 27, 2006.Applicant
European Search Report EP 05020666.3 dated Feb. 27, 2006.Applicant
European Search Report EP 05021025.1 dated Mar. 13, 2006.Applicant
European Search Report EP 05021197.8 dated Feb. 20, 2006.Applicant
European Search Report EP 05021777 dated Feb. 23, 2006.Applicant
European Search Report EP 05021779.3 dated Feb. 2, 2006.Applicant
Sylvain Labonte et al., “Monopole Antennas for Microwave Catheter Ablation”, IEEE Trans. on Microwave Theory and Techniques, vol. 44, No. 10, pp. 1832-1840, Oct. 1995.Applicant
T. Matsukawa et al., “Percutaneous Microwave Coagulation Therapy in Liver Tumors”, Acta Radiologica, vol. 38, pp. 410-415, 1997.Applicant
T. Seki et al., (1994) “Ultrasonically Guided Percutaneous Microwave Coagulation Therapy for Small Hepatocellular Carcinoma,” Cancer 74(3):817-825.Applicant
Urologix, Inc.—Medical Professionals: Targis™ Technology (Date Unknown). “Overcoming the Challenge” located at: <http://www.urologix.com!medicaUtechnology.html > last visited on Apr. 27, 2001, 3 pages.Applicant
Urrutia et al., (1988). “Retractable-Barb Needle for Breast Lesion Localization: Use in 60 Cases,” Radiology 169(3):845-847.Applicant
Valleylab Brochure, “Valleylab Electroshield Monitoring System” 2 pages, Nov. 1995.Applicant
ValleyLab Brochure, “Electosurgery: A Historical Overview”, Innovations in Electrosurgery, 1999.Applicant
Vallfors et al., “Automatically Controlled Bipolar Electrocoagulation-‘COA-COMP’” Neurosurgical Review 7:2-3 (1984) pp. 187-190.Applicant
W. Scott Helton, “LigaSure™ Vessel Sealing System: Revolutionary Hemostasis Product for General Surgery” Sales/Product Literature 1999.Applicant
Wald et al., “Accidental Burns”, JAMA, Aug. 16, 1971, vol. 217, No. 7, pp. 916-921.Applicant
Walt Boyles, “Instrumentation Reference Book”, 2002, Butterworth-Heinemann, pp. 262-264.Applicant
European Search Report EP 98300964.8 dated Dec. 13, 2000.Applicant
European Search Report EP 98944778 dated Nov. 7, 2000.Applicant
European Search Report EP 98958575.7 dated Oct. 29, 2002.Applicant
Peterson et al., “Comparison of Healing Process Following Ligation with Sutures and Bipolar Vessel Sealing” Surgical Technology International (2001).Applicant
R. Gennari et al., (Jun. 2000) “Use of Technetium-99m-Labeled Colloid Albumin for Preoperative and Intraoperative Localization of Non palpable Breast Lesions,” American College of Surgeons. 190(6):692-699.Applicant
Valleylab Brochure, “Reducing Needlestick Injuries in the Operating Room” 1 page, Mar. 2001.Applicant
Reidenbach, (1995) “First Experimental Results with Special Applicators for High-Frequency Interstitial Thermotherapy”, Society Minimally Invasive Therapy, 4(Suppl 1):40 (Abstr).Applicant
Richard Wolf Medical Instruments Corp. Brochure, “Kleppinger Bipolar Forceps & Bipolar Generator” 3 pages, Jan. 1989.Applicant
Rothenberg et al., “Use of the LigaSure™ Vessel Sealing System in Minimally Invasive Surgery in Children” Int'l Pediatric Endosurgery Group (I PEG) 2000.Applicant
Sayfan et al., “Sutureless Closed Hemorrhoidectomy: A New Technique” Annals of Surgery, vol. 234, No. 1, Jul. 2001, pp. 21-24.Applicant
Sengupta et al., “Use of a Computer-Controlled Bipolar Diathermy System in Radical Prostatectomies and Other Open Urological Surgery” ANZ Journal of Surgery (2001) 71.9 pp. 538-540.Applicant
Sigel et al., “The Mechanism of Blood Vessel Closure by High Frequency Electrocoagulation” Surgery Gynecology & Obstetrics, Oct. 1965 pp. 823-831.Applicant
Solbiati et al., (2001) “Percutaneous Radio-frequency Ablation of Hepatic Metastases from Colorectal Cancer: Long-term Results in 117 Patients”, Radiology, vol. 221, pp. 159-166.Applicant
Strasberg et al., “Use of a Bipolar Vassel-Sealing Device for Parenchymal Transection During Liver Surgery” Journal of Gastrointestinal Surgery, vol. 6, No. 4, Jul./Aug. 2002 pp. 569-574.Applicant
Stuart W. Young, Nuclear Magnetic Resonance Imaging—Basic Principles, Raven Press, New York, 1984.Applicant
Sugita et al., “Bipolar Coagulator with Automatic Thermocontrol” J. Neurosurg., vol. 41, Dec. 1944, pp. 777-779.Applicant
MDTECH product literature (Dec. 1999) “FlexStrand”: product description, 1 page.Applicant
MDTECH product literature (Mar. 2000) I'D Wire: product description, 1 page.Applicant
Medtrex Brochure “The O.R. Pro 300” 1 page, Sep. 1998.Applicant
Michael Choti, “Abdominoperineal Resection with the LigaSure™ Vessel Sealing System and LigaSure™ Atlas 20 cm Open Instrument” Innovations That Work, Jun. 2003.Applicant
Muller et al., “Extended Left Hemicolectomy Using the LigaSure™ Vessel Sealing System” Innovations That Work. LJ, Sep. 1999.Applicant
Murakami, R. et al., (1995). “Treatment of Hepatocellular Carcinoma: Value of Percutaneous Microwave Coagulation,” American Journal of Radiology (AJR) 164:1159-1164.Applicant
Ni Wei et al., “A Signal Processing Method for the Coriolis Mass Flowmeter Based on a Normalized . . . ” Journal of Applied Sciences•Yingyong Kexue Xuebao, Shangha CN, vol. 23, No. 2:(Mar. 2005); pp. 160-184.Applicant
Ogden, “Goertzel Alternative to the Fourier Transform” Jun. 1993 pp. 485-487 Electronics World; Reed Business Publishing, Sutton, Surrey, BG, vol. 99, No. 9, 1687.Applicant
Olsson M.D. et al., “Radical Cystectomy in Females” Current Surgical Techniques in Urology, vol. 14, Issue 3, 2001.Applicant
Organ, L W., “Electrophysiologic Principles of Radiofrequency Lesion Making” Appl. Neurophysiol, vol. 39: pp. 69-76 (1976/77).Applicant
P.R. Stauffer et al., “Interstitial Heating Technologies”, Thermoradiotheray and Thermochemotherapy (1995) vol. I, Biology, Physiology, Physics, pp. 279-320.Applicant
Palazzo et al., “Randomized clinical trial of LigaSure™ versus open haemorrhoidectomy” British Journal of Surgery 2002,89,154-157 “Innovations in Electrosurgery” Sales/Product Literature; Dec. 31, 2000.Applicant
Paul G. Horgan, “A Novel Technique for Parenchymal Division During Hepatectomy” The American Journal of Surgery, vol. 181, No. 3, Apr. 2001, pp. 236-237.Applicant
Joseph G. Andriole M.D. et al., “Biopsy Needle Characteristics Assessed in the Laboratory”, Radiology 148: 659-662, Sep. 1983.Applicant
Joseph Ortenberg, “LigaSure™ System Used in Laparoscopic 1st and 2nd Stage Orchiopexy” Innovations That Work, Nov. 2002.Applicant
K. Ogata, Modern Control Engineering, Prentice-Hall, Englewood Cliffs, N.J., 1970.Applicant
Kennedy et al., “High-burst-strength, feedback-controlled bipolar vessel sealing” Surgical Endoscopy (1998) 12: 876-878.Applicant
Kopans, D.B. et al., (Nov. 1985) “Spring Hookwire Breast Lesion Localizer: Use with Rigid-Compression. Mammographic Systems,” Radiology 157(2):537-538.Applicant
Koyle et al., “Laparoscopic Palomo Varicocele Ligation in Children and Adolescents” Pediatric Endosurgery & Innovative Techniques, vol. 6, No. 1, 2002.Applicant
LigaSure™ Vessel Sealing System, the Seal of Confidence in General , Gynecologic, Urologic, and Laparaoscopic Surgery, Sales/Product Literature, Jan. 2004.Applicant
Livraghi et al., (1995) “Saline-enhanced RF Tissue Ablation in the Treatment of Liver Metastases”, Radiology, pp. 205-210.Applicant
Lyndon B. Johnson Space Center, Houston, Texas, “Compact Directional Microwave Antenna for Localized Heating,” NASA Tech Briefs, Mar. 2008.Applicant
M. A. Astrahan, “A Localized Current Field Hyperthermia System for Use with 192-Iridium Interstitial Implants” Medical Physics. 9(3), May/Jun. 1982.Applicant
Magdy F. Iskander et al., “Design Optimization of Interstitial Antennas”, IEEE Transactions on Biomedical Engineering, vol. 36, No. 2, Feb. 1989, pp. 238-246.Applicant
McGahan et al., (1995) “Percutaneous Ultrasound-guided Radiofrequency Electrocautery Ablation of Prostate Tissue in Dogs”, Acad Radiol , vol. 2, No. 1: pp. 61-65.Applicant
McLellan et al., “Vessel Sealing for Hemostasis During Pelvic Surgery” Int'l Federation of Gynecology and Obstetrics FIGO World Congress 2000, Washington, DC.Applicant
Esterline Product Literature, “Light Key: Visualize a Virtual Keyboard. One With No Moving Parts”, Nov. 1, 2003; 4 pages.Applicant
Geddes et al., “The Measurement of Physiologic Events by Electrical Impedence” Am. J. MI, Jan. Mar. 1964, pp. 16-27.Applicant
Goldberg et al., “Image-guided Radiofrequency Tumor Ablation: Challenges and Opportunities—Part I”, (2001) J Vasc. Interv. Radiol, vol. 12, pp. 1021-1032.Applicant
Goldberg et al., “Tissue Ablation with Radiofrequency: Effect of Probe Size, Gauge, Duration, and Temperature on Lesion Volume” Acad Radio (1995) vol. 2, No. 5, pp. 399-404.Applicant
H. Schwarzmaier et al., “Magnetic Resonance Imaging of Microwave Induced Tissue Heating” Dept. of Laser Medicine & Dept. of Diagnostic Radiology; Heinrich-Heine-University, Duesseldorf, Germany; Dec. 8, 1994; pp. 729-731.Applicant
Heniford et al., “Initial Results with an Electrothermal Bipolar Vessel Sealer” Surgical Endoscopy (2001) 15:799-801.Applicant
Herman at al., “Laparoscopic Intestinal Resection With the LigaSure™ Vessel Sealing System: A Case Report” Innovations That Work, Feb. 2002.Applicant
Humphries Jr. et al., “Finite-Element Codes to Model Electrical Heating and Non-LInear Thermal Transport in Biological Media”, Proc. ASME HTD-355, 131 (1997).Applicant
Ian D. McRury et al., The Effect of Ablation Sequence and Duration on Lesion Shape Using Rapidly Pulsed Radiofrequency Energy Through Electrodes, Feb. 2000, Springer Netherlands, vol. 4; No. 1, pp. 307-320.Applicant
Jarrett et al., “Use of the LigaSure™ Vessel Sealing System for Peri-Hilar Vessels in Laparoscopic Nephrectomy” Sales/Product Literature 2000.Applicant
Johnson et al., “Evaluation of a Bipolar Electrothermal Vessel Sealing Device in Hemorrhoidectomy” Sales/Product Literature, Jan. 2004.Applicant
Johnson, “Evaluation of the LigaSure™ Vessel Sealing System in Hemorrhoidectormy” American College of Surgeons (ACS) Clinic La Congress Poster (2000).Applicant
Johnson, “Use of the LigaSure™ Vessel Sealing System in Bloodless Hemorrhoidectomy” Innovations That Work, Mar. 2000.Applicant
Carbonell et al., “Comparison of the Gyrus PlasmaKinetic Sealer and the Valleylab LigaSure™ Device in the Hemostasis of Small, Medium, and Large-Sized Arteries” Carolinas Laparoscopic and Advanced Surgery Program, Carolinas Medical Center, Charlotte, NC 2003.Applicant
Carus et al., “Initial Experience With the LigaSure™ Vessel Sealing System in Abdominal Surgery” Innovations That Work, Jun. 2002.Applicant
Chicharo et al., “A Sliding Goertzel Algorithm” Aug. 1996 DOS pp. 283-297 Signal Processing, Elsevier Science Publishers B.V. Amsterdam, NL, vol. 52, No. 3.Applicant
Chou, C.K., (1995) “Radiofrequency Hyperthermia in Cancer Therapy,” Chapter 941n Biologic Effects of Nonionizing Electromagnetic Fields, CRC Press, Inc., pp. 1424-1428.Applicant
Chung et al., “Clinical Experience of Sutureless Closed Hemorrhoidectomy with LigaSure™” Diseases of the Colon & Rectum, vol. 46, No. 1, Jan. 2003.Applicant
Cosman et al., “Methods of Making Nervous System Lesions” In William RH, Rengachary SS (eds): Neurosurgery, New York: McGraw-Hill, vol. 111, (1984), pp. 2490-2499.Applicant
Cosman et al., “Radiofrequency Lesion Generation and its Effect on Tissue Impedence”, Applied Neurophysiology, 51:230-242, 1988.Applicant
Cosman et al., “Theoretical Aspects of Radiofrequency Lesions in the Dorsal Root Entry Zone” Neurosurgery 15:(1984), pp. 945-950.Applicant
Crawford et al., “Use of the LigaSure™ Vessel Sealing System in Urologic Cancer Surger” Grand Rounds in Urology 1999, vol. 1, Issue 4, pp. 10-17.Applicant
Dulemba et al., “Use of a Bipolar Electrothermal Vessel Sealer in Laparoscopically Assisted Vaginal Hysterectomy” Sales/Product Literature; Jan. 2004.Applicant
E. David Crawford, “Evaluation of a New Vessel Sealing Device in Urologic Cancer Surgery” Sales/Product Literature 2000.Applicant
E. David Crawford, “Use of a Novel Vessel Sealing Technology in Management of the Dorsal Veinous Complex” Sales/Product Literature 2000.Applicant
Esterline, “Light Key Projection Keyboard” 2004 Advanced Input Systems, located at: <http://www.advanced-input.com/lightkey> last visited on Feb. 10, 2005.Applicant
Anonymous. (1987) Homer Mammalok™ Breast Lesion Needle/Wire Localizer, Namic® Angiographic Systems Division, Glens Falls, New York, (Hospital products price list), 4 pages.Applicant
Anonymous. (1999) MIBB Site Marker, United States Surgical (Sales brochure), 4 pages.Applicant
Anonymous. Blunt Tubes with Finished Ends. Pointed Cannula, Popper & Sons Biomedical Instrument Division, (Products Price List), one page, Jul. 19, 2000.Applicant
Anonymous. Ground Cannulae, ISPG, New Milford, CT, (Advertisement) one page, Jul. 19, 2000.Applicant
B. Levy M.D. et al., “Randomized Trial of Suture Versus Electrosurgical Bipolar Vessel Sealing in Vaginal Hysterectomy” Obstetrics & Gynecology, vol. 102, No. 1, Jul. 2003.Applicant
B. Levy M.D. et al., “Update on Hysterectomy New Technologies and Techniques” OBG Management, Feb. 2003.Applicant
B. Levy M.D., “Use of a New Vessel Ligation Device During Vaginal Hysterectomy” FIGO 2000, Washington, D.C.Applicant
B. F. Mullan et al., (May 1999) “Lung Nodules: Improved Wire for CT-Guided Localization,” Radiology 211:561-565.Applicant
B. T. Heniford M.D. et al., “Initial Research and Clinical Results with an Electrothermal Bipolar Vessel Sealer” Oct. 1999.Applicant
Bergdahl et al., “Studies on Coagulation and the Development of an Automatic Computerized Bipolar Coagulator” Journal of Neurosurgery 75:1 (Jul. 1991), pp. 148-151.Applicant
Bulletin of the American Physical Society, vol. 47, No. 5, Aug. 2002, p. 41.Applicant
C. F. Gottlieb et al., “Interstitial Microwave Hyperthermia Applicators having Submillimetre Diameters”, Int. J. Hyperthermia, vol. 6, No. 3, pp. 707-714, 1990.Applicant
C. H. Durney et al., “Antennas for Medical Applications”, Antenna Handbook: Theory Application and Design, p. 24-40, Van Nostrand Reinhold, 1988 New York, V.T. Lo, S.W. Lee.Applicant
Alexander et al., “Magnetic Resonance Image-Directed Stereotactic Neurosurgery: Use of Image Fusion with Computerized Tomography to Enhance Spatial Accuracy” Journal Neurosurgery, 83 (1995), pp. 271-276.Applicant
Anderson et al., “A Numerical Study of Rapid Heating for High Temperature Radio Frequency Hyperthermia” International Journal of Bio-Medical Computing, 35 (1994), pp. 297-307.Applicant
Anonymous. (1999) Auto Suture MIBB Site Marker: Single Use Clip Applier, United States Surgical (Product instructions), 2 pages.Applicant
Anonymous. (2001) Disposable Chiba Biopsy Needles and Trays, Biopsy and Special Purpose Needles Cook Diagnostic and Interventional Products Catalog (products list), 4 pages.Applicant
U.S. Appl. No. 12/542,348, filed Aug. 17, 2009.Applicant
U.S. Appl. No. 12/542,785, filed Aug. 18, 2009.Applicant
U.S. Appl. No. 12/547,155, filed Aug. 25, 2009.Applicant
U.S. Appl. No. 12/548,644, filed Aug. 27, 2009.Applicant
U.S. Appl. No. 12/555,576, filed Sep. 8, 2009.Applicant
U.S. Appl. No. 12/556,010, filed Sep. 9, 2009.Applicant
U.S. Appl. No. 12/561,096, filed Sep. 16, 2009.Applicant
U.S. Appl. No. 12/562,575, filed Sep. 18, 2009.Applicant
U.S. Appl. No. 12/562,842, filed Sep. 18, 2009.Applicant
U.S. Appl. No. 12/566,299, filed Sep. 24, 2009.Applicant
U.S. Appl. No. 12/568,067, filed Sep. 28, 2009.Applicant
U.S. Appl. No. 12/568,524, filed Sep. 28, 2009.Applicant
U.S. Appl. No. 12/568,551, filed Sep. 28, 2009.Applicant
U.S. Appl. No. 12/568,777, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/568,838, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/568,883, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/568,972, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/569,171, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/569,685, filed Sep. 29, 2009.Applicant
U.S. Appl. No. 12/582,857, filed Oct. 21, 2009.Applicant
U.S. Appl. No. 12/606,769, filed Oct. 27, 2009.Applicant
U.S. Appl. No. 12/607,221, filed Oct. 28, 2009.Applicant
U.S. Appl. No. 12/607,268, filed Oct. 28, 2009.Applicant
U.S. Appl. No. 12/619,462, filed Nov. 16, 2009.Applicant
U.S. Appl. No. 12/620,289, filed Nov. 17, 2009.Applicant
U.S. Appl. No. 12/199,935, filed Aug. 28, 2008.Applicant
U.S. Appl. No. 12/203,474, filed Sep. 3, 2008.Applicant
U.S. Appl. No. 12/236,686, filed Sep. 24, 2008.Applicant
U.S. Appl. No. 12/244,850, filed Oct. 3, 2008.Applicant
U.S. Appl. No. 12/250,110, filed Oct. 13, 2008.Applicant
U.S. Appl. No. 12/250,171, filed Oct. 13, 2008.Applicant
U.S. Appl. No. 12/251,857, filed Oct. 15, 2008.Applicant
U.S. Appl. No. 12/253,457, filed Oct. 17, 2008.Applicant
U.S. Appl. No. 12/366,298, filed Feb. 5, 2009.Applicant
U.S. Appl. No. 12/389,906, filed Feb. 20, 2009.Applicant
U.S. Appl. No. 12/389,915, filed Feb. 20, 2009.Applicant
U.S. Appl. No. 12/401,268, filed Mar. 10, 2009.Applicant
U.S. Appl. No. 12/416,583, filed Apr. 1, 2009.Applicant
U.S. Appl. No. 12/419,395, filed Apr. 7, 2009.Applicant
U.S. Appl. No. 12/423,609, filed Apr. 14, 2009.Applicant
U.S. Appl. No. 12/434,903, filed May 4, 2009.Applicant
U.S. Appl. No. 12/436,237, filed May 6, 2009.Applicant
U.S. Appl. No. 12/436,239, filed May 6, 2009.Applicant
U.S. Appl. No. 12/436,231, filed May 6, 2009.Applicant
U.S. Appl. No. 12/472,831, filed May 27, 2009.Applicant
U.S. Appl. No. 12/475,082, filed May 29, 2009.Applicant
U.S. Appl. No. 12/476,960, filed Jun. 2, 2009.Applicant
U.S. Appl. No. 12/487,917, filed Jun. 19, 2009.Applicant
U.S. Appl. No. 12/493,302, filed Jun. 29, 2009.Applicant
U.S. Appl. No. 12/504,738, filed Jul. 17, 2009.Applicant
U.S. Appl. No. 12/508,700, filed Jul. 24, 2009.Applicant
U.S. Appl. No. 12/535,851, filed Aug. 5, 2009.Applicant
U.S. Appl. No. 12/535,856, filed Aug. 5, 2009.Applicant
U.S. Appl. No. 12/536,616, filed Aug. 6, 2009.Applicant
U.S. Appl. No. 08/483,742, filed Jun. 7, 1995.Applicant
U.S. Appl. No. 08/136,098, filed Oct. 14, 1993.Applicant
U.S. Appl. No. 12/129,482, filed May 29, 2008.Applicant
U.S. Appl. No. 12/135,425, filed Jun. 9, 2008.Applicant
U.S. Appl. No. 12/135,690, filed Jun. 9, 2008.Applicant
U.S. Appl. No. 12/147,093, filed Jun. 26, 2008.Applicant
U.S. Appl. No. 12/181,504, filed Jul. 29, 2008.Applicant
U.S. Appl. No. 12/184,556, filed Aug. 1, 2008.Applicant
U.S. Appl. No. 12/194,254, filed Aug. 19, 2008.Applicant
U.S. Appl. No. 12/197,601, filed Aug. 25, 2008.Applicant
U.S. Appl. No. 12/197,405, filed Aug. 25, 2008.Applicant
U.S. Appl. No. 12/197,473, filed Aug. 25, 2008.Applicant
European Search Report EP 09161502.1 dated Jun. 10, 2010 (9 pages).Applicant

Abstract