US 8,025,635 B2Grant
Device and methods for treating paranasal sinus conditions
Issue Date:2011-09-27
•17 Claims
•24 Drawing Sheets
Abstract
Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
Metadata
Assignee
- Intersect ENT, Inc.
Inventors
- Donald J. Eaton
- Thomas R. Tice
- David B. Downie
- Patrick A. Arensdorf
- Rodney Brenneman
- Danielle L. Biggs
Application Information
Application Number:US 11/398,342
Filing Date:2006-04-04
Priority Date:2005-04-04
Art Unit:3763
Classifications
IPC:
A61M31/00
Patent Drawings (24 sheets)
Description
RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Application Ser. No. 60/668,569, filed Apr. 4, 2005, which is hereby incorporated by reference in its entirety.
FIELD
[0002] The devices, systems, and methods described here are in the field of local drug delivery to treat paranasal sinus conditions. More specifically, the treatment of paranasal sinus inflammation and rhinosinusitis is described.
BACKGROUND
[0003] Rhinosinusitis is a common paranasal sinus condition that is generally understood as encompassing sinusitis and/or rhinitis. Typically, rhinosinusitis is characterized by such major symptoms such as nasal discharge, nasal obstruction, facial congestion, facial pain/pressure, loss of smell, and fever, and such minor symptoms as headache, ear pain/pressure, halitosis, dental pain, cough, and fatigue.
[0004] The paranasal sinuses are air-filled cavities within the facial skeleton. Each paranasal sinus is contiguous with a nasal cavity and opens into the nasal cavity through a sinus ostium. The key to normal sinus function is its mucociliary transport system which is comprised of epithelial goblet cells and submucosal seromucous glands that produce nearly a quart of mucus in the sinus a day, and a ciliated, pseudostratified, columnar epithelium that lines the sinuses and which moves the mucous toward the natural sinus ostia. Any alteration in sinus ostia patency, ciliary function, or the quality of mucous may disrupt the system and lead to rhinosinusitis.
[0005] One important factor in the pathogenesis of rhinosinusitis is the patency of the sinus ostia. Partial obstruction of the sinus ostia often results in stagnation of mucous secretions, and a decrease in pH and oxygen tension within the sinus. These physiologic changes are thought to create a favorable environment for microbial infection. The microbial infection subsequently causes or enhances mucosal inflammation that may further reduce ostial patency or completely obstruct the ostia.
[0006] The medical treatment for rhinosinusitis typically includes a combination of oral antibiotics, topical or oral decongestants, steroid nasal sprays, or oral steroids such as prednisone. When medical therapy fails, which is often the case with rhinosinusitis, sinus surgery is an alternative. The most common surgery performed today is functional endoscopic sinus surgery (FESS). The goal of FESS is to improve the drainage of the sinuses by enlarging the ostia of the maxillary and frontal sinuses, and opening the ethmoid sinus area by removing the ethmoid air cells under direct visualization. However, FESS itself creates inflammation, which can lead to post-operative fibrosis, stenosis, and/or polyposis that frequently obstructs the newly opened sinuses, requiring the surgeon to reoperate to revise the ostia and insert stenting devices to keep sinus ostia patent.
[0007] U.S. Pat. No. 5,246,455 (Shikani) and U.S. Pat. No. 5,693,065 (Rains) describe stents for insertion into sinus ostia and/or sinus antrostomies or fenestrations to improve sinus drainage, reduce the degree of adhesion formation, and prevent ostial stenosis. Furthermore, stents such as the Parrell Frontal Sinus T-Stent (Medtronic Xomed, Inc., Jacksonville, Fla.), the Jasin Frontal Sinus Ostent™ Stent (Medtronic Xomed, Inc., Jacksonville, Fla.), and the Salman FES Stent (Boston Medical Products, Westborough, Mass.) are currently used after endoscopic sinus surgery for the same purpose. However, these stents are nonbiodegradable and thus require a follow-up procedure for removal. Furthermore, because these stents do not deliver a therapeutically active agent to the sinuses, they often only delay stenosis due to postoperative inflammation and the normal wound healing process. Thus, they are typically used in combination with systemic oral corticosteroids, which may result in undesirable side-effects the longer they are administered.
[0008] Sinus stents that elute drug have been proposed by others. For example, a nonbiodegradable or biodegradable polymeric “spacer” device for placement into surgically created frontal sinus fenestrations is described in U.S. Published Application No. U.S. 2004/0116958 to Goferich et al. The spacer is tubular or shaped like an hour-glass, and capable of releasing medicinal substances such as glucocorticosteroids, tyrosine kinase inhibitors, and mitosis inhibitors around newly created fenestrations. An hour-glass or tubular shape is described as preferred because it allows secretions to drain from the sinus. The spacer is placed solely at the sinus ostium and does not undergo a structural change, for example, to transition between a collapsed and expanded configuration, upon delivery to the sinus ostium. Furthermore, the spacer primarily lies within the natural ostium or surgically created fenestration. It does not have a portion that extends into the sinus cavity to contact the sinus cavity wall.
[0009] Another implantable device for treating sinusitis is described in U.S. Publication No. 2005/0245906 to Makower et al. This application describes a biodegradable polymeric device having a spacer for positioning within a sinus ostium, and a body comprised of a plurality of substance-eluting struts. The struts are configured to lie substantially parallel to the flow of mucus along the sinus cavity walls without substantially touching the walls so that mucociliary transport is not interrupted. It is uncertain how a device of this design would be constructed or deployed. Furthermore, given that the sinus mucosa is a source of water needed for device degradation and drug release, it is questionable whether this device is capable of providing a dosing regimen effective for treating rhinosinusitis because it does not substantially contact the walls of the sinus cavity.
[0010] Other compositions for the treatment of rhinosinusitis, such as aqueous solutions, creams, or gels, for topical application in the nose have also been formulated, but usually never travel far enough into the nose to reach the sinuses, are blocked from entering the sinuses due to obstructed ostia, or have such short contact with the sinus mucosa that absorption of the agent is low. For similar reasons, nasally inhaled steroid and anti-infective aerosols that have been developed to treat sinusitis are equally ineffective.
[0011] Another method that has been described for locally treating sinusitis is to place a biodegradable implant into the sinus. For example, the delivery of ampicillin from a rolled-up 1.5 cm×1.5 cm poly(lactic-co-glycolic)acid (PLGA) film to increase residence time of the antibiotic in rabbit sinuses has been investigated for the treatment of sinusitis (Min et al. Mucociliary Activity and Histopathology of Sinus Mucosa in Experimental Maxillary Sinusitis: A Comparison of Systemic Administration of Antibiotic and Antibiotic Delivery by Polylactic Acid Polymer. Laryngoscope 105:835-342 (1995) and Min et al. Application of Polylactic Acid Polymer in the Treatment of Acute Maxillary Sinusitis in Rabbits. Acta Otolaryngol 115:548-552 (1995)). Although clinical signs of sinusitis improved over 28 days, the procedure for placing the film was quite invasive, requiring that a hole be drilled through the anterior wall of the maxillary sinus.
[0012] A less invasive method of placing a biodegradable implant into a sinus for the local treatment of sinusitis is described in commonly owned U.S. Publication No. 2005/0043706. In this application, the implant is generally delivered into the sinus through a sinus ostium, and has at least one characteristic that substantially prevents its clearance by the mucociliary transport system. For example, the implant is typically formed to possess a mucoadhesiveness that substantially prevents implant clearance from the sinus. A mucoadhesive polymer is incorporated into the implant to make it mucoadhesive. Mucoadhesive polymers are usually hydrophilic, and upon moistening, absorb water to swell and become adhesive. This implant lacks a structural component that physically maintains patency of the sinus ostium.
[0013] Consequently, new devices for locally administering active agents to the paranasal sinuses for treating paranasal sinus conditions, e.g., sinus inflammation (including, but not limited to, rhinosinusitis and sinus procedures, e.g., FESS), and for maintaining patency of sinus ostia, as well as methods for delivering the devices to the sinus cavity are desirable.
SUMMARY
[0014] The devices, systems, and methods of this invention are generally used to treat patients having a paranasal sinus condition. The paranasal sinus condition to be treated is typically postoperative paranasal sinus inflammation due to functional endoscopic sinus surgery (FESS) for sinusitis, but also includes conditions such as, but not limited to, acute sinusitis, chronic sinusitis, allergic rhinitis, rhinosinusitis, sinusitis that recurs after FESS, upper respiratory tract infections, otitis media, bronchitis, bronchiolitis, asthma, tonsillitis and other chronic diseases of the tonsils and adenoids, laryngitis, tracheitis, nasal and sinus polyposis, neoplasms of the large and small airways, and nasal, sinus, or nasopharynx tumors such as nasopharyngeal carcinoma, plasmacytomas, inverted papillomas, rhabdomyosarcomas, squamous cell carcinomas, and lymphomas, when they involve the sinuses or nasal passage. As used herein, the terms “paranasal sinus inflammation” or “sinus inflammation” refer to any reaction of sinus tissue, sinus ostial tissue, or tissue in the nasal passage proximate the sinus ostia that involves the inflammatory response. The inflammation may be caused by processes such as allergy (hypersensitivity), injury to sinus mucosa due to, e.g., trauma; surgery; infection by bacteria, viruses, fungi, chemicals, or drugs; and benign or malignant tumors.
[0015] The devices are formed in such a way to locally deliver one or more active agents into the sinus cavity, sinus ostium, and/or nasal passage for at least about one week to treat the paranasal sinus condition. The described devices are useful in surgical, non-surgical, and other therapeutic interventions related to the paranasal sinuses and nasal passages to restore anatomical function and treat any of the aforementioned conditions. Accordingly, the devices may be used to support sinus and nasal surgery, reduce the need for surgical revision, and/or prevent, delay, or reduce recurrence of rhinosinusitis.
[0016] The devices for treating paranasal sinus conditions may include a cavity member that has a first collapsed configuration that permits the device to pass through a sinus ostium and a second expanded configuration after placement into the sinus cavity. As used herein, the terms “expand”, “expansion”, or “expanding”, refer to a device that undergoes physical expansion, e.g., from a compressed to an expanded state, not expansion due to the absorption of water.
[0017] In their expanded configuration, the devices in some variations have a surface area to volume ratio that is substantially unchanged from that of the devices in their collapsed configuration. In other variations, upon expansion, the cavity member also at least partially conforms to the shape of the sinus cavity and substantially contacts the mucosa of the sinus cavity. The devices may be made from any biocompatible material. For example, they may be formed from various metals and their alloys, biodegradable or nonbiodegradable polymers, and combinations thereof.
[0018] In addition to a cavity member, the devices may include a nasal portion and an ostial member that is configured to reside within the sinus ostium. The cavity member is attached to the distal end of the ostial member. The nasal portion is attached to the proximal end of the ostial member and lies within the nasal passage. The active agent may be incorporated into all portions of the device or only included in the expandable cavity member, the ostial member, or nasal portion. In one aspect, the active agent is released from the cavity member and the ostial member. In another aspect, the active agent is released from the cavity member and nasal portion. In yet a further aspect, the active agent is released from the nasal portion and the ostial member. The cavity member, ostial member, and nasal portion may contain and deliver the same or different active agents.
[0019] The paranasal sinus devices may deliver an active agent(s) over at least about one week, over at least about two weeks, over at least about three weeks, over at least about one month, over at least about two months, over at least about three months, over at least about four months, over at least about five months, or over at least about six months or more. Typically, the active agent is delivered over about four weeks.
[0020] The devices may be formed from one or more polymeric pliable filaments. For example, the filaments may be configured to form cavity members that resemble a fringed structure, a flexible mesh, a whisk-like structure, and the like. The cavity members may be formed to be expandable. In one variation, the cavity members self-expand. In another variation, the devices expand after application of an expansive or mechanical force. For example, the devices may expand after balloon inflation. In some instances, the cavity members expand to substantially contact the sinus cavity wall after deployment within the sinus. Contact with the sinus cavity wall may be verified by incorporation of radiopaque markers on or within the cavity members, or visualization using endoscopy or other imaging modalities.
[0021] In another variation, the pliable filament(s) may contain a plasticizer or a solvent which softens the biodegradable or nonbiodegradable polymer. Balloon inflation or other mechanical types of expansion may be used to expand variations of the plasticized cavity member that are not configured to self-expand. Upon contact of the plasticized cavity member to the mucosal tissue, the plasticizer diffuses out of the cavity member. The plasticizer diffusion hardens the cavity member in such a way that the cavity member substantially conforms to the shape of the sinus cavity. As an example, a filament made from lactide/glycolide polymer may be plasticized with materials such as triethyl citrate, acetone and other ketones, ethanol and other alcohols, N-methylpyrrolidone, ethyl acetate and mixtures thereof. Upon placement of the filament into the sinus, the plasticizer, triethyl citrate, for example, diffuses out of the filament polymer to result in a hardened filament that substantially conforms to the shape of the sinus cavity.
[0022] The devices described here for treating a paranasal sinus condition may include an active agent dispersed within a biodegradable polymer matrix, in which the device comprises a cavity member, an ostial member, and optionally a nasal portion, and exhibits an in vivo cumulative release profile in which a therapeutically effective amount of said active agent is maintained in a sinus tissue for at least about 4 days, at least about 14 days, at least about 25 days, or at least about 35 days after implantation of the device.
[0023] The paranasal sinus devices may be delivered into a sinus using inserters of various designs. Typical inserters include a conduit, e.g., a catheter, needle, or angiocatheter, having a lumen. For example, the conduit may be made such that it has variable stiffness along its length. In addition, the distal portion of the conduit may be pre-angulated to facilitate access of the sinus ostium, or made such that the distal portion is malleable such that the physician may angulate the conduit prior to accessing the sinus ostium.
[0024] The paranasal sinus devices and inserters for their deployment may be used in a system for treating a paranasal sinus condition. In general, the system works by first placing the inserter having one or more devices in a collapsed, folded, or constrained configuration within or carried on its distal end through the sinus ostium. Once within the sinus, the cavity member of the device transitions from the first collapsed, folded, or constrained configuration to a second expanded configuration. For example, a sheath may be retracted to slidably deploy a self-expanding cavity member that contacts a substantial portion of the sinus cavity wall. Balloon inflation or other mechanical types of expansion may be used to expand variations of the cavity member that are not configured to self-expand.
DESCRIPTION OF THE DRAWINGS
[0025] FIG. 1 is a cross-sectional view of a maxillary and frontal sinus.
[0026] FIGS. 2A-2M are transverse cross-sectional views of various pliable filaments.
[0027] FIG. 3A is a cross-sectional view of a maxillary sinus device having a fringed structure according to one variation of the invention.
[0028] FIG. 3B is a cross-sectional view of the paranasal sinus device of FIG. 3A in a maxillary sinus.
[0029] FIG. 4A is a cross-sectional view of a frontal sinus device having a fringed structure according to another variation of the invention.
[0030] FIG. 4B is a cross-sectional view of the paranasal sinus device of FIG. 4A in a frontal sinus.
[0031] FIG. 5A is a side view of a paranasal sinus device including an expandable mesh according to another variation of the invention.
[0032] FIG. 5B is a side view of the paranasal sinus device of FIG. 5A prior to expansion.
[0033] FIGS. 6A-6F are side cross-sectional view of various filament anchoring mechanisms.
[0034] FIGS. 7A-7R are perspective views of various cavity member configurations.
[0035] FIGS. 8A-8C show perspective, ostial, and end views of a coil-like ostial member.
[0036] FIGS. 9A-9C show perspective, ostial, and end views of a accordion-like ostial member.
[0037] FIGS. 10A-10C show perspective, ostial, and end views of a mesh-like ostial member.
[0038] FIGS. 11A-11C depict perspective, ostial, and end views of a star-like ostial member.
[0039] FIGS. 12A-12C show perspective, ostial, and end views of a hexagonal shaped ostial member.
[0040] FIGS. 13A-13C depict perspective, ostial, and end views of a furled sheet-like ostial member.
[0041] FIGS. 14A-14C depict perspective, ostial, and end views of a tubular ostial member.
[0042] FIGS. 15A-15C show perspective, ostial, and end views of an ostial member formed from a plurality of pliable filaments.
[0043] FIGS. 16A-16C depict perspective, ostial, and end views of an ostial member formed from a plurality of pliable ribbon-like or strip-like filaments.
[0044] FIGS. 17A-17C show perspective, ostial, and end views of an ostial member configured as an expandable pleated tube.
[0045] FIGS. 18A-18C show perspective, ostial, and end views of an ostial member made from gel foam.
[0046] FIGS. 19A-19C show perspective, ostial, and end views of a cylindrical ostial member having a plurality of lumens.
[0047] FIGS. 20A-20F illustrate various nasal portion configurations.
[0048] FIG. 21 depicts a perspective view of an exemplary paranasal sinus device.
[0049] FIGS. 22A-22C show perspective, side cross-sectional, and end views of a paranasal sinus device having a cavity member and nasal portion formed from multiple loops of pliable filaments.
[0050] FIGS. 23A-23C show perspective, side cross-sectional, and end views of a paranasal sinus device having a looped cavity member and a nasal plate.
[0051] FIGS. 24A-24F show exemplary drug release curves for the paranasal sinus devices.
[0052] FIG. 25 is a graph showing cumulative in vitro release of mometasone furoate from various paranasal sinus devices over a 30-day time period.
DETAILED DESCRIPTION
[0053] The paranasal sinus devices of this invention may take various forms. For example, some are designed to include a cavity member, an ostial member, and a nasal portion, and deliver active agents for the treatment of paranasal sinus conditions, e.g., sinus inflammation. The cavity member may have a first collapsed configuration that permits it to be inserted through a sinus ostium or surgically created fenestration, and a second expanded configuration upon placement into the sinus cavity. In this variation, once expanded, the structure of the cavity member generally has a surface area to volume ratio that is not substantially different from the surface area to volume ratio of the cavity member in its collapsed configuration. This may be important because the sinus mucosa is a source of water needed for the release of the active agent from the paranasal sinus device. Thus, if the surface area of a device available for contacting the sinus mucosa is decreased, e.g., in relation to its volume, dissolution (and subsequent absorption) of the active agent should also be decreased. Furthermore, once expanded, the cavity member may also substantially contact the sinus cavity wall.
[0054] The nasal portion generally functions to position and/or anchor the device at the sinus ostium, preventing lateralization of the middle turbinate, occlusion of the middle meatus, and formation of tissue adhesions. The ostial member located at the proximal end of the cavity member typically functions to maintain patency of the sinus ostium. However, as further described below, each component of the device may have various functions, depending on factors such as the particular structure of the cavity member, ostial member, or nasal portion and whether the component is capable of releasing an active agent.
[0055] As used herein, the terms “paranasal sinus” and “sinus” are used interchangeably, and refer to all sinuses, i.e., the maxillary, frontal, ethmoid, and sphenoidal sinuses. Each sinus cavity opens into the nasal cavity through a sinus ostium. As shown in FIG. 1 , the maxillary sinus 10 opens into nasal cavity 12 at maxillary sinus ostium 14, and the frontal sinus 16 opens into nasal cavity 12 at frontal sinus ostium 18. As used herein, the terms “treat”, “treating”, or “treatment” refer to the resolution, reduction, or prevention of a paranasal sinus condition or its symptoms, prevention of complications attributable to a paranasal sinus condition, or provision of a beneficial substance, to a paranasal sinus. For example, the beneficial substance may be used to promote general health of the sinus.
[0056] Once expanded, the cavity member may be configured to conform at least partly to the shape of the sinus cavity and substantially contact the sinus cavity wall. By “substantially contact” it is meant the percentage of surface area of the cavity member generally required to contact a sinus cavity wall (sinus mucosa) that provides the appropriate release kinetics for the active agents throughout a treatment period, for example, for at least one week, for at least two weeks, for at least three weeks, or for at least four weeks or more. Accordingly, depending on the amount of surface area needed for contact, “substantial contact” may refer to contact of about 10% to about 100%, about 20% to about 100%, about 30% to about 100%, about 40% to about 100%, about 50% to about 100%, about 60% to about 100%, about 70% to about 100%, about 80% to about 100%, or about 90% to about 100% of the surface area of the device to the sinus cavity wall. Importantly, the pressure of the cavity member on the sinus mucosa is sufficient for maintaining contact of the cavity member against the sinus mucosa but does not cause significant damage or necrosis to the mucosa.
[0057] As used herein, the terms “active agent”, “therapeutic agent”, and “drug” are used interchangeably and refer to any substance used to treat a paranasal sinus condition. Furthermore, as used herein, the term “therapeutic amount” refers to a concentration of active agent that has been locally delivered to a sinus or nasal passage that is appropriate to safely treat a paranasal sinus condition.
[0058] General elements. The paranasal sinus devices described here may be configured in a variety of ways. For example, they may be formed from one or more filaments, which include any linear structure such as strands, capillaries and tubular and non-tubular structures, but may also be formed from a film or sheet-like starting material. The filaments may be of variable stiffness and take a variety of suitable forms, such as threads, ribbons, strips, beaded structures, tubes, and the like, so long as they are flexible enough to substantially contact a portion of a sinus cavity wall after deployment, exhibit the desired release kinetics, and deliver an amount of drug therapeutic for a paranasal sinus condition. The filaments may be of different shapes generally, and have a variety of cross-sectional shapes, as desired or as useful to maintain mucosal contact and consistent deployment. For example, as shown in FIGS. 2A-2M , they may be shaped to be circular (2A), square (2B), elliptical (2C), winged (2D), diamond-like (2E), rectangular (2F), wedged (2G), ramped (2H), tubular (2I), parallelogram-like (2J), arc-like (2K), dog bone/dumbbell shaped (2L), slightly concave (2M), and the like on transverse cross-section. If desired, the pliable filaments may also be combined to form woven structures such as cords, ropes, braids, mesh, and the like. Tubular filaments may be combined into structures with multiple lumens, in either concentric or adjacent configurations, or directly formed as filaments with multiple lumens. Films and sheets may also include non-woven meshes and largely two dimensional materials, where dimensional thickness is much less than dimensional length or width. Other materials such as gelfoam may form such filaments upon their application.
[0059] In some variations the pliable filaments may be configured to include one or more anchoring elements to help affix the filaments to the sinus mucosa or otherwise enhance contact of the filaments to the sinus mucosa. For example, as shown in FIGS. 6A-6F , the anchoring element may be one or more hooks (6A), spikes (6B), opposed spikes (6C), arrows (6D), ridges (6E), barbs (6F), and the like. In FIG. 6E , ridges may also be formed to be triangular, square, round, semicircular, and the like.
[0060] Cavity member. The cavity members are generally biodegradable, but they may also be made to be nonbiodegradable. Additionally, whether formed as biodegradable or nonbiodegradable, the cavity members may be attached to a component, for example, a wire or suture, that extends from the cavity member and out through the ostium, which could be grasped by an instrument to remove it from the sinus.
[0061] In one variation, the pliable filaments are configured to form a fringed structure. As shown in FIG. 3A , a cross-section of fringed structure 20 includes a plurality of pliable filaments or prongs 22 (expanded configuration). Pliable filaments 22 are secured at their proximal ends 24 to a tubular ostial member 26. Once deployed in a paranasal sinus such as maxillary sinus 21 in FIG. 3B , pliable filaments 22 radially expand, unfurl, or otherwise are adapted to undergo a change in configuration after insertion into a sinus, to substantially contact the sinus cavity wall 23 and to deliver an active agent into the sinus 21. The length of the pliable filaments 22 is usually between about 1 cm and about 6 cm, more usually between about 2 cm to about 6 cm, and more usually still between about 3 cm and 6 cm. In addition, ostial member 26 is placed at the sinus ostium 25 to maintain ostium patency so that drainage from the sinus 21 to the nasal cavity is uninterrupted. Nasal portion 28 may also be provided on the proximal end of the device. Nasal portion 28 extends into the nasal cavity and may minimize lateralization of the middle turbinate to the lateral nasal wall and ostia opening, further reducing the possible risk of occlusion and adhesion formation in the middle meatus.
[0062] In another variation, shown in FIGS. 4A and 4B , pliable filaments 32 are configured to form a fringed structure 30 in a frontal sinus 31. Like in FIGS. 3A and 3B , pliable filaments 32 are secured to ostial member 36 at their proximal ends 34, and once deployed, substantially contact the sinus cavity wall 38 to deliver drug into frontal sinus 31. The length of pliable filaments 32 are usually between about 1 cm and about 5 cm, and more usually between about 2 cm and about 5 cm. However, because of the longer passageway from the nasal cavity to the frontal sinus ostium 33 than to the maxillary ostium, and because the frontal sinus device 30 is subject to gravitational pull, as well as encompasses a longer narrower cavity prone to stenosis, adhesions and scarring, the tubular ostial member 36 is generally formed to be longer in a frontal sinus device. However, the length of ostial member 36 may be shortened if the fringed structure 30 (or other cavity member) is configured to anchor the device within the sinus cavity, or if the risk of such aforementioned complications has been reduced through varying surgical techniques (more or less extensive) or anatomical variations.
[0063] Turning to the variation shown in FIGS. 5A and 5B , the pliable filaments are configured to form a flexible mesh. In FIG. 5B (collapsed configuration), flexible mesh 40 is secured to an ostial member 42 (and in some instances, also to nasal portion 46) by methods well known in the art, e.g., by welding, annealing, heat bonding, attachment bands or adhesives such as thermoplastic adhesives, thermosetting adhesives, rubber-resin blend adhesives, and other adhesives well known in the art. Upon expansion, as shown in FIG. 5A , flexible mesh 40 forms a spherical structure capable of at least partially conforming to the shape of a sinus cavity. The weave of the mesh may be adjusted to be looser or tighter, or the width of the pliable filaments may be adjusted to correspondingly adjust the flexibility of the mesh. The flexible mesh may be expanded to a diameter between about 1 cm to about 5 cm, and more usually between about 2 cm to about 5 cm, and as further described below, may form a self-expanding, controllably expandable, or balloon expandable cavity member.
[0064] The cavity member may be of various other designs. In one variation, the cavity member 70 is configured as a single pliable filament 72 (FIG. 7A ). Single pliable filament 72 may curve in such a way to at least partially conform to the shape of the sinus of implantation and substantially contact the sinus cavity wall. In another variation, as shown in FIG. 7B , the cavity member 74 comprises a single pliable filament configured as a coil 76. The number of turns of the coil will vary depending on such factors as the sinus of implantation, placement and deployment technique used, and whether or not the coil is to be used as an anchor or for drug delivery, and flexibility of the filament. Similarly, a cavity member 78 may be made from a single pliable filament configured and/or inserted as a random coil 80 (FIG. 7C ).
[0065] In other variations, the cavity member is formed from a plurality of one or more arced or looped filaments. For example, in FIG. 7D , the expanded cavity member 82 is formed from two pliable filaments 84. Pliable filaments 84 are configured to form concentric loops crossing each other. The loops are usually affixed to each other by methods described above to form a distal apex 86. The proximal ends 88 of pliable filaments 84 may be joined and otherwise configured to form an ostial member 230 and/or nasal portion 232, e.g., as shown in FIG. 21 . In another variation, expanded cavity member 90 is formed from a plurality of pliable filaments 92 configured to form multiple free loops (FIG. 7E ). The proximal ends 94 of pliable filaments 92 may also be joined or otherwise configured to form an ostial member and/or nasal portion of the device. In yet a further variation, as shown in FIG. 7F , the expanded cavity member may be formed from a plurality of pliable filaments 98 configured as a whisk-like structure. The spacing 100 between the filaments may be varied depending on the particular desired cavity member configuration. The filaments may be shaped by adjusting their degree of flexibility, e.g., by addition of plasticizer, use of various molding, casting, bonding, and extrusion techniques, and by other methods well known in the art. The angle between each looped filament may also be varied depending on the particular desired cavity member configuration. Any number of filaments may also be employed to fabricate devices with any number of arced or looped cavity members.
[0066] In yet other variations, the cavity members may be formed from ribbon or strip-like filaments. For example, as shown in FIG. 7G , the cavity member 100 is formed from a plurality of strip-like sub-filaments 102 resulting from slitting a single tubular filament structure. In FIG. 7H , the cavity member 104 is formed from a plurality of strip-like filaments 106 configured as a pronged structure. In FIG. 71 , the cavity member 108 is made from a plurality of strip-like filaments 110 resulting from slitting and deformation of “children” filaments from the end of a single “parent” tubular filament structure.
[0067] FIGS. 7J-7O show yet further cavity member design variations. In FIG. 7J , cavity member 112 is formed from a plurality of corrugated ribbon-like filaments. In FIG. 7K , cavity member 116 is formed from a plurality of filaments configured like springs 118. The cavity member may also be made from one or more filaments 122 comprising gelfoam. FIGS. 7M-7O also include features allowing the irreversible deployment of one or more filaments in an open or tensed configuration using ridges (for example 134, 136) on the filaments and opposing ridges upon the adjacent lumens or other structures at their insertion site. In FIG. 7M , a cavity member 124 consisting of a single ridged loop is inserted into the sinus and against the sinus wall (arrows) through a lumen with an opposing ridge 125 on the ostial member 126 of the device. In FIG. 7N , a cavity member 128 consisting of two opposed loops 129 is similarly inserted. These ridges 130 may alternatively deform the structure of the sinus cavity member. In FIG. 7O , a cavity member 131 of the type described in above in FIG. 7I is modified by the addition of ridges 133 on the interior of strip-like filaments 135, and an additional interior tubular member with opposing ridges 137 positioned concentrically within the parent slit tube. The device's cavity member strip-like filaments 135 are deployed through their deformation along the intersection of the strip ridges and those of the opposing interior ridges as the concentric member 137 is independently pulled back (towards the proximal direction) while maintaining constant the position of the external sinus cavity parent slit tube. The result is a splayed and deformed open pattern of slit “children” filaments along the sinus cavity wall.
[0068] In FIG. 7R , the cavity member 132 is formed from a plurality of filaments 134 woven as a mesh and configured as a funnel-type structure. The cavity members may also be formed from a film, non-woven, or sheet-like material. For example, the film or sheet may be pleated, as shown in FIGS. 7P and 7Q . In FIG. 7P the sheet 140 has pleats 138 that allow the cavity member 136 to be configured as a pleated cone. In FIG. 7Q , the sheet 142 has pleats 144 that allow the cavity member 146 to be configured as a pleated fan.
[0069] The cavity members of the invention may be adapted to self-expand, e.g., if they are made from a shape memory polymer or if they are constrained by a sheath prior to sinus insertion and deployed in the sinus after retraction of the sheath. They may also be expanded via methods involving mechanical expansion. For example, they may be expanded by inflating a balloon or pulling a cord or wire attached to the distal end of the device, or by the application of expansive force at the proximal end of the device, or by deflecting or deforming the cavity member along the sinus walls. However, in addition to the methods previously described, the invention also contemplates mechanical expansion of cavity members made from less pliable filaments that are equipped with one or more joints or hinges and which expand by movement of the pliable filaments at the joints or hinges. The joint or hinge may be an area of greater flexibility along the filament due to use of a polymer in that area having a lower durometer, decreasing the width of the filament, or by adjusting other surface features or mass density of the filament in that area.
[0070] The active agent may be included in any portion of the device, e.g., the cavity member, ostial member, and/or nasal portion. When filaments are used, the active agent may be incorporated in the filaments as drug dispersed or dissolved within a polymeric matrix, or coated on the pliable filaments, or first encapsulated, such as microencapsulated, and then incorporated within or coated onto the pliable filaments. In some instances, the pliable filaments may be constructed to have one or more pouches or pockets for holding pellets of drug. The dosage of active agent delivered by the cavity member may be adjusted by, e.g., increasing or decreasing the number of drug-containing filaments in the cavity member, increasing or decreasing the amount of drug contained within or coated on the filaments, or by forming the pliable filaments such that they can be broken or cut into smaller filaments either before or after insertion into a sinus cavity. For example, the pliable filaments may include predetermined fracture lines or markings that a physician can use as a guide to adjust filament length prior to insertion, or after insertion into the sinus, the filaments may be adapted to preferentially degrade at the fracture lines into smaller filaments. In some instances, it may be desirable to include filaments having different active agents in the cavity member.
[0071] Cavity members may also be made from a combination of pliable filament configurations or from combinations of filaments and other described cavity member configurations. For example, the structures of FIGS. 3A-3B and FIGS. 4A-4B could be used to support the flexible mesh of FIG. 5A . If desired, a radiopaque marker may also be included on one or more pliable filaments to indicate the degree of expansion of the cavity member upon radiographic imaging. Usually, the marker will be detected by fluoroscopy, and if nonbiodegradable, will exit the sinus with the normal mucus flow if and after the expandable cavity member has degraded. Biodegradable radiopacifiers such as particles of an iodinated contrast agent or bismuth salts may also be used. Contact with the sinus cavity wall may be verified by incorporation of radiopaque markers on or within the cavity members, or visualization using endoscopy or other imaging modalities.
[0072] Contact and/or anchoring of the cavity member to the sinus cavity wall may be enhanced by the addition of mucoadhesive materials, that may or may not be polymeric, to the pliable filaments, as further described below, by adjusting filament dimensions (e.g., decreasing filament diameter or otherwise decreasing aspect ratio), or by forming the filaments, as shown in FIGS. 6A-6F , such that they include hooked (7A), spiked (7B), double spiked (7C), arrow-like (7D), ridged (7E), or barb-like structures (7F), or other anchoring or texturizing elements for grasping the sinus mucosa. In other variations, the filaments may be configured toward their distal ends as screws or springs which are capable of being fixed in sinus mucosa or other sinus tissue by insertion or tension. In yet other variations, the filaments may be fixed to the sinus cavity wall by stapling or suturing. The cavity member may also be anchored in the sinus by adjusting its size such that it is too large to move out of the ostium, or configuring the cavity member such that it expands to fill the entire sinus cavity or expands to exert sufficient pressure to maintain it within the sinus cavity. Furthermore, the paranasal sinus devices may have pliable filaments configured to have flexibility such that portions of the cavity members can differentially bow to conform to the shape of the sinus in which it is deployed.
[0073] Ostial member. The ostial member may be used to keep the ostia patent and/or anchor the nasal portion or cavity member of the device. In some variations, its inclusion may be to simply connect the cavity member to a nasal portion or other extra-sinus portion of the device. The ostial member is mounted to the proximal end of the cavity member, and is positioned at or relatively near the sinus ostium. Again, the pressure generated by the ostial member on the sinus mucosa is sufficient to keep the ostium open, but not so great that it compromises blood flow to the sinus mucosa.
[0074] The ostial member may be of various designs. In some variations, the ostial member is formed form a one or more pliable filaments. For example, in FIG. 8A , ostial member 148 is formed from a single pliable filament 150 configured as an expandable coiled filament or wire which may be varied in its pitch, number and density of coils, coil linear and non-linear or patterned architecture and other like features. FIG. 8B shows the corkscrew ostial member 148 positioned within an ostium, and FIG. 8C shows an end view ostial member 148. Lumen 151 allows flow of mucus out of the sinus cavity. Ostial member 148 is adapted to be laterally compressible and/or bendable as shown by the arrows in FIG. 8B , in which case the coil diameter will increase or decrease. In another variation, as shown in FIG. 15A , a plurality of filaments 154, which may be tubular filaments (having lumens), are attached to form tubular ostial member 152. FIG. 15B shows the tubular ostial member 152 within a sinus ostium and FIG. 15C shows an end view of the ostial member 152. Lumen 156 allows flow of mucus out of the sinus cavity, as would the lumens of any tubular filament(s) if used in its construction. The ostial member 158 shown in FIGS. 16A-16C is similar to that in FIGS. 15A-15C except that the filaments 160 are formed as strips. Ostial member 158 also has a lumen 162 that permits mucus to flow from the sinus cavity to into the nasal passage.
[0075] In other variations, the ostial member is formed from a film or sheet-like material. For example, in FIG. 9A , ostial member 164 is formed from a pleated sheet (or alternatively from a plurality of tubular ring structures linked together) 166 configured as a reversibly compressible and/or bendable (as indicated by arrows in FIG. 9B ) accordion-like tubular structure. FIG. 9B depicts ostial member 164 within a sinus ostium, and FIG. 9C shows an end view of ostial member 164. Lumen 168 allows flow of mucus out of the sinus cavity. Referring now to FIG. 10A , ostial member 170 includes a plurality of shaped apertures 172 cut out or punched out from film or sheet material 174, creating a non-woven mesh Although the apertures are shown as hexagonal in shape, it is understood that various other aperture shapes may be used. For example, the apertures 172 may be triangles, squares, octagons, diamonds, etc. FIG. 10B shows ostial member 170 within a sinus ostium. In FIG. 10C , it is shown how an ostial member of this design allow mucus to flow out through lumen 176 as well as through apertures 172 (see direction of arrows). Ostial member 170 may be also be formed to be compressible, expandable, bendable, and the like. Referring to FIGS. 12A-12C , 14A-14C, and 13A-13C, the film or sheet-like material 176 may also be configured to form a simple tube 178, a tubular hexagon 180, and a furled tube 182. Lumens 184, 186, and 188 allow passage of mucus from the sinus cavity to the nasal passage. Pressure may be applied in the direction of the arrows to the furled tube 182 in FIG. 13C to adjust the diameter of lumen 188.
[0076] In another variation, the ostial member 164 is formed from a plurality of sheets or strip-like filaments 166 configured as a star or asterisk-like structure. Spaces 168 between each strip allow mucus to flow past the ostial member 164 and optionally through a central lumen 165. FIG. 11B shows ostial member 164 within a sinus ostium, and FIG. 11C depicts an end view of ostial member 164. Further variations are illustrated in FIGS. 17-19 . Referring to FIGS. 17A-17C , tubular ostial member 190 (top) is formed from a corrugated or pleated film or sheet 192. The ostial member 190 may be expanded in the direction of the arrows (shown in FIG. 17C ) to form an ostial member of larger diameter 194. In FIGS. 18A-18C , the tubular ostial member 196 is made from gelfoam 198, with a pierced lumen 199, which may or not be supported by the addition of a tube. The ostial member 200 in FIGS. 19A-19C is a solid but porous cylinder 204 having a plurality of lumens 202. Lumens 202 extend through the tubular ostial member 200, either directly (as in a tube) or indirectly by connection through other internal cavities and/or lumens (not shown) such that mucus may pass out the end walls 206 and outer wall 208 of cylinder 204.
[0077] The ostial member may be formed to be rigid or flexible, and may also be formed to be coated with drug, coated with microencapsulated drug, or made as a polymer matrix with dispersed or dissolved drug. The drug included with the ostial member may be the same or different from that delivered by the expandable cavity member. The ostial member may be made from a biodegradable or nonbiodegradable polymer, a metal, or combinations thereof.
[0078] The dimensions of the ostial member will generally vary with the intended sinus of deployment. For example, for the maxillary sinus, the length of the ostial member may be less than 2 mm, but is usually between about 2 mm to about 6 mm, more usually between about 2 mm to about 5 mm, and more usually still between about 2 mm to about 4 mm. The outer diameter of the maxillary ostial member is usually between about 5 mm to about 10 mm, more usually between about 5 mm to about 9 mm, and more usually still between about 8 mm to about 10 mm. The internal diameter of the maxillary ostial member is usually between about 3 mm to about 9 mm, more usually between about 3 mm to about 8 mm, and more usually still between about 3 mm to about 7 mm.
[0079] For the frontal sinus, the length of the ostial member may be between about 0.5 mm to about 5 cm, between about 0.5 cm to about 4 cm, between about 0.5 cm to about 3 cm, between about 0.5 cm to about 2 cm, or between about 0.5 cm to about 1 cm. The outer diameter of the ostial member is usually about 5 mm, and the internal diameter about 3 mm. However, the inner and outer diameters may be smaller, especially in the instance where anchoring of the device is accomplished by the cavity member or nasal portion.
[0080] Nasal portion. The paranasal sinus devices of the invention may include a nasal portion, e.g., a nasal plate 210 (FIG. 20D ), to aid in maintaining the position of the ostial member at the sinus ostium, or as an aid in reducing turbinate lateralization, possible occlusion of the middle meatus around the ostia, and tissue adhesions. If included, the nasal portion (e.g., element 46 in FIGS. 5A-5B and element 232 in FIG. 21 ) is secured to the proximal end of the ostial member to extend into the nasal passage, and may lie against the nasal mucosa. The nasal portion is configured to have at least one opening through which mucus flowing from the ostial member can drain into the nasal passage. The opening may be eccentrically located, or formed to be in the center of the nasal portion. In FIG. 20D , opening 212 is in the center of nasal plate 210. In FIG. 20E , nasal plate 214 has a plurality of openings 216 that allow drainage of mucus from the sinus into the nasal passage.
[0081] In other variations, the nasal portion is configured from one or more pliable filaments. Referring to FIG. 20A , nasal portion 218 is formed from a plurality of filaments 220 configured as radially extending spokes, which may be inserted as a more compact bundle of aligned parallel spokes, then deployed or unfurled so as to encircle the insertion point (see arrows and insertion view). Similarly, in FIG. 20C , nasal portion 226 is formed from a plurality of strip-like filaments 228. In FIG. 20B , nasal portion 222 is formed from a single pliable filament 224 configured as a spiral/helical structure. Another exemplary nasal portion is depicted in FIG. 20F , which comprises a compressible woven or nonwoven fold of sheeted material in the form of a wing-shaped tube, intended to adjustably conform to and support the middle meatus space and turbinate anatomy directly outside of an ostium.
[0082] The nasal portion may be formed to be rigid, flexible, or self-expanding, and may also be formed to be coated with drug, coated with microencapsulated drug, or made as a polymer matrix with dispersed or dissolved drug within the polymer matrix. The drug included with the nasal portion may be the same or different from that delivered by the cavity member. The nasal portion may be made from a biodegradable or nonbiodegradable polymer, a metal, or combinations thereof.
[0083] The shape of the nasal portion may also vary depending on such factors as the sinus of deployment and whether additional sinuses, e.g., the ethmoid sinus, are to be treated. For example, in an individual needing treatment for both maxillary and ethmoid sinus inflammation, a maxillary paranasal sinus device having a nasal portion shaped to contact a portion of the ethmoid air cells is particularly desirable.
[0084] The paranasal sinus devices may include any combination of the aforementioned cavity members, ostial members, and nasal portions. For example, as shown in FIG. 21 , device may include a multiple looped cavity member 228 (previously described for FIG. 7D ) and a tubular ostial member (previously described for FIG. 15A ). Nasal portion 232 is also formed from a plurality of filaments 234 configured as splayed prongs. Each component of the device, i.e., the cavity member, ostial member, and nasal portion, may be formed contiguously (each filament, tube, sheet, or film forms all components) or separately, and then attached by methods previously described. Each component may also be perforated, contain pores, or have other structural or surface features which enhance or alternatively prevent impedence of mucociliary clearance, and aid in the placement and deployment of the device.
[0085] In another variation, paranasal sinus device 236 includes a whisk-like cavity member 238 (previously described for FIG. 7F ), a tubular ostial member 240 (previously described for FIG. 14A ), and another whisk-like component 242 similar to cavity member 238 as the nasal portion 242. FIG. 22C shows an end view from the nasal portion of the device.
[0086] In a further variation, shown in FIGS. 23A-23C , paranasal sinus device 244 includes a multiple looped cavity member 246 (previously described for FIG. 7D ) and a nasal plate 248 (previously described for FIG. 20D . FIG. 23B is a side cross-sectional view of device 244 and an cross-section end view through line A-A is shown in FIG. 23C .
[0087] Active agents. Any active agent may be included in the devices described herein so long as they are suitable to treat a paranasal sinus condition and are capable of achieving the desired release kinetics. The active agents that may be used in a paranasal sinus device to treat a paranasal sinus condition include, but are not limited to, anticholinergic agents, antihistamines, anti-infective agents, anti-inflammatory agents, antiscarring or antiproliferative agents, chemotherapeutic/antineoplastic agents, cytokines such as interfereon and interleukins, decongestants, healing promotion agents and vitamins (e.g., retinoic acid, vitamin A, and their derivatives), hyperosmolar agents, immunomodulator/immunosuppressive agents, leukotriene modifiers, mucolytics, narcotic analgesics, small molecules, tyrosine kinase inhibitors, peptides, proteins, nucleic acids, vasoconstrictors, or combinations thereof. Anti-sense nucleic acid oligomers or other direct transactivation and/or transrepression modifiers of mRNA expression, transcription, and protein production may also be used. Anti-infective agents generally include antibacterial agents, antifungal agents, antiparasitic agents, antiviral agents, and antiseptics. Anti-inflammatory agents generally include steroidal and nonsteroidal anti-inflammatory agents.
[0088] Examples of antibacterial agents that may be suitable for use with the described methods and devices include, but are not limited to, aminoglycosides, amphenicols, ansamycins, β-lactams, lincosamides, macrolides, nitrofurans, quinolones, sulfonamides, sulfones, tetracyclines, vancomycin, and any of their derivatives, or combinations thereof. In one variation, β-lactams are the preferred antibacterial agents.
[0089] β-lactams that may be suitable for use with the described methods and devices include, but are not limited to, carbacephems, carbapenems, cephalosporins, cephamycins, monobactams, oxacephems, penicillins, and any of their derivatives. In one variation, penicillins (and their corresponding salts) are the preferred β-lactams.
[0090] The penicillins that may be suitable for use with the described methods and devices include, but are not limited to, amdinocillin, amdinocillin pivoxil, amoxicillin, ampicillin, apalcillin, aspoxicillin, azidocillin, azlocillin, bacampicillin, benzylpenicillinic acid, benzylpenicillin sodium, carbenicillin, carindacillin, clometocillin, cloxacillin, cyclacillin, dicloxacillin, epicillin, fenbenicillin, floxacillin, hetacillin, lenampicillin, metampicillin, methicillin sodium, mezlocillin, nafcillin sodium, oxacillin, penamecillin, penethamate hydriodide, penicillin G benethamine, penicillin G benzathine, penicillin G benzhydrylamine, penicillin G calcium, penicillin G hydrabamine, penicillin G potassium, penicillin G procaine, penicillin N, penicillin O, penicillin V, penicillin V benzathine, penicillin V hydrabamine, penimepicycline, phenethicillin potassium, piperacillin, pivampicillin, propicillin, quinacillin, sulbenicillin, sultamicillin, talampicillin, temocillin, and ticarcillin. In one variation, amoxicillin may be included in the paranasal sinus device. In another variation, the device includes ampicillin. Penicillins combined with clavulanic acid such as Augmentin® (amoxicillin and clavulanic acid) may also be used.
[0091] Examples of antifungal agents suitable for use with the described methods and devices include, but are not limited to, allylamines, imidazoles, polyenes, thiocarbamates, triazoles, and any of their derivatives. In one variation, imidazoles are the preferred antifungal agents. Antiparasitic agents that may be employed include such agents as atovaquone, clindamycin, dapsone, iodoquinol, metronidazole, pentamidine, primaquine, pyrimethamine, sulfadiazine, trimethoprim/sulfamethoxazole, trimetrexate, and combinations thereof.
[0092] Examples of antiviral agents suitable for use with the described methods and devices include, but are not limited to, acyclovir, famciclovir, valacyclovir, edoxudine, ganciclovir, foscamet, cidovir (vistide), vitrasert, formivirsen, HPMPA (9-(3-hydroxy-2-phosphonomethoxypropyl)adenine), PMEA (9-(2-phosphonomethoxyethyl)adenine), HPMPG (9-(3-Hydroxy-2-(Phosphonomet-hoxy)propyl)guanine), PMEG (9-[2-(phosphonomethoxy)ethyl]guanine), HPMPC (1-(2-phosphonomethoxy-3-hydroxypropyl)-cytosine), ribavirin, EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamine), pyrazofurin (3-[beta-D-ribofuranosyl]-4-hydroxypyrazole-5-carboxamine), 3-Deazaguanine, GR-92938X (1-beta-D-ribofuranosylpyrazole-3,4-dicarboxami-de), LY253963 (1,3,4-thiadiazol-2-yl-cyanamide), RD3-0028 (1,4-dihydro-2,3-Benzodithiin), CL387626 (4,4′-bis[4,6-d]3-aminophenyl-N-,N-bis(2-carbamoylethyl)-sulfonilimino]-1,3,5-triazin-2-ylamino-biphenyl-2-,2′-disulfonic acid disodium salt), BABIM (Bis[5-Amidino-2-benzimidazoly-1]-methane), NIH351, and combinations thereof.
[0093] Typically, if inclusion of an anti-inflammatory agent is desired, a steroidal anti-inflammatory agent, e.g., a corticosteroid, is employed. Examples of steroidal anti-inflammatory agents that may be used in the devices include 21-acetoxypregnenolone, alclometasone, algestone, amcinonide, beclomethasone, betamethasone, budesonide, chloroprednisone, clobetasol, clobetasone, clocortolone, cloprednol, corticosterone, cortisone, cortivazol, deflazacort, desonide, desoximetasone, dexamethasone, diflorasone, diflucortolone, difluprednate, enoxolone, fluazacort, flucloronide, flumethasone, flunisolide, fluocinolone acetonide, fluocinonide, fluocortin butyl, fluocortolone, fluorometholone, fluperolone acetate, fluprednidene acetate, fluprednisolone, flurandrenolide, fluticasone propionate, formocortal, halcinonide, halobetasol propionate, halometasone, halopredone acetate, hydrocortamate, hydrocortisone, loteprednol etabonate, mazipredone, medrysone, meprednisone, methylprednisolone, mometasone furoate, paramethasone, prednicarbate, prednisolone, prednisolone 25-diethylamino-acetate, prednisolone sodium phosphate, prednisone, prednival, prednylidene, rimexolone, tixocortol, triamcinolone, triamcinolone acetonide, triamcinolone benetonide, triamcinolone hexacetonide, any of their derivatives, and combinations thereof. In one variation, budesonide is included in the device as the steroidal anti-inflammatory agent. In another variation, the steroidal anti-inflammatory agent may be mometasone furoate. In yet another variation, the steroidal anti-inflammatory agent may be beclomethasone. In yet a further variation, the steroidal anti-inflammatory agent may be fluticasone propionate.
[0094] If a nonsteroidal anti-inflammatory agent is used, suitable agents include, but are not limited to, COX inhibitors (COX-1 or COX nonspecific inhibitors) (e.g., salicylic acid derivatives, aspirin, sodium salicylate, choline magnesium trisalicylate, salsalate, diflunisal, sulfasalazine and olsalazine; para-aminophenol derivatives such as acetaminophen; indole and indene acetic acids such as indomethacin and sulindac; heteroaryl acetic acids such as tolmetin, dicofenac and ketorolac; arylpropionic acids such as ibuprofen, naproxen, flurbiprofen, ketoprofen, fenoprofen and oxaprozin; anthranilic acids (fenamates) such as mefenamic acid and meloxicam; enolic acids such as the oxicams (piroxicam, meloxicam) and alkanones such as nabumetone) and selective COX-2 inhibitors (e.g., diaryl-substituted furanones such as rofecoxib; diaryl-substituted pyrazoles such as celecoxib; indole acetic acids such as etodolac and sulfonanilides such as nimesulide).
[0095] The chemotherapeutic/antineoplastic agents that may be used in the paranasal sinus devices include, but are not limited to antitumor agents (e.g., cancer chemotherapeutic agents, biological response modifiers, vascularization inhibitors, hormone receptor blockers, cryotherapeutic agents or other agents that destroy or inhibit neoplasia or tumorigenesis) such as alkylating agents or other agents which directly kill cancer cells by attacking their DNA (e.g., cyclophosphamide, isophosphamide), nitrosoureas or other agents which kill cancer cells by inhibiting changes necessary for cellular DNA repair (e.g., carmustine (BCNU) and lomustine (CCNU)), antimetabolites and other agents that block cancer cell growth by interfering with certain cell functions, usually DNA synthesis (e.g., 6 mercaptopurine and 5-fluorouracil (5FU), antitumor antibiotics and other compounds that act by binding or intercalating DNA and preventing RNA synthesis (e.g., doxorubicin, daunorubicin, epirubicin, idarubicin, mitomycin-C and bleomycin) plant (vinca) alkaloids and other anti-tumor agents derived from plants (e.g., vincristine and vinblastine), steroid hormones, hormone inhibitors, hormone receptor antagonists and other agents which affect the growth of hormone-responsive cancers (e.g., tamoxifen, herceptin, aromatase ingibitors such as aminoglutethamide and formestane, trriazole inhibitors such as letrozole and anastrazole, steroidal inhibitors such as exemestane), antiangiogenic proteins, small molecules, gene therapies and/or other agents that inhibit angiogenesis or vascularization of tumors (e.g., meth-1, meth-2, thalidomide), bevacizumab (Avastin), squalamine, endostatin, angiostatin, Angiozyme, AE-941 (Neovastat), CC-5013 (Revimid), medi-522 (Vitaxin), 2-methoxyestradiol (2ME2, Panzem), carboxyamidotriazole (CAI), combretastatin A4 prodrug (CA4P), SU6668, SU11248, BMS-275291, COL-3, EMD 121974, IMC-1C11, IM862, TNP-470, celecoxib (Celebrex), rofecoxib (Vioxx), interferon alpha, interleukin-12 (IL-12) or any of the compounds identified in Science Vol. 289, Pages 1197-1201 (Aug. 17, 2000), which is expressly incorporated herein by reference, biological response modifiers (e.g., interferon, bacillus calmette-guerin (BCG), monoclonal antibodies, interluken 2, granulocyte colony stimulating factor (GCSF), etc.), PGDF receptor antagonists, herceptin, asparaginase, busulphan, carboplatin, cisplatin, carmustine, cchlorambucil, cytarabine, dacarbazine, etoposide, flucarbazine, flurouracil, gemcitabine, hydroxyurea, ifosphamide, irinotecan, lomustine, melphalan, mercaptopurine, methotrexate, thioguanine, thiotepa, tomudex, topotecan, treosulfan, vinblastine, vincristine, mitoazitrone, oxaliplatin, procarbazine, streptocin, taxol or paclitaxel, taxotere, analogs/congeners, derivatives of such compounds, and combinations thereof.
[0096] Exemplary decongestants that may be incorporated in the paranasal sinus devices, include, but are not limited to, epinephrine, pseudoephedrine, oxymetazoline, phenylephrine, tetrahydrozolidine, and xylometazoline. Mucolytics that may be used include, but are not limted to, acetylcysteine, domase alpha, and guaifenesin. Anti-histamines such as azelastine, diphenhydramine, and loratidine may also be used.
[0097] In those instances where it is desirable to remove water from tissue, e.g, to remove fluid from polyps or edematous tissue, a hyperosmolar agent may be employed. Suitable hyperosmolar agents include, but are not limited to, furosemide, sodium chloride gel, or other salt preparations that draw water from tissue or substances that directly or indirectly change the osmolar content of the mucous layer.
[0098] The active agent may constitute from about 0.01% to about 95%, 0.01% to about 95%, from about 0.01% to about 90%, from about 0.01% to about 80%, from about 0.01% to about 70%, from about 0.01% to about 60%, from about 0.01% to about 50%, from about 0.01% to about 40%, from about 0.01% to about 30%, from about 0.01% to about 20%, from about 0.01% to about 10%, from about 0.01% to about 5%, from about 0.01% to about 1%, or from about 0.01% to about 0.25% by weight of the releasing portion (e.g., the cavity member, ostial member, and/or nasal portion) or releasing material (e.g., layer or layers having the active agent) of the device. The amount of active agent used will usually depend on factors such as the particular agent incorporated, the paranasal sinus condition being treated, and the severity of clinical symptoms, but in all instances will usually be an amount that is effective for treating the paranasal sinus condition upon delivery into a sinus. For example, when treating paranasal sinus inflammation, the device may be formed to deliver per day, from about 1 μg to about 100 μg, from about 10 μg to about 50 μg, from about 10 μg to about 40 μg, from about 10 μg to about 30 μg, from about 10 μg to about 25 μg, or from about 10 μg to about 20 μg of mometasone furoate into the sinus. In another variation, the device may be formed to deliver per day, from about 10 μg to about 700 μg, from about 25 μg to about 400 μg, from about 75 μg to about 300 μg, or about 100 to about 200 μg of fluticasone propionate into the sinus. In some instances, crystal forms, e.g., hydrous and anhydrous crystal forms, of drugs may be used in the methods and devices described here. For example, mometasone furoate monohydrate may be used.
[0099] The active agent may be incorporated and released from the cavity member, ostial member, and/or the nasal portion. In another variation, the active agent may be coated onto the surface of the cavity member, ostial member, and/or the nasal portion. An exemplary way the coating may be achieved is by dissolving or suspending the active agent in a solution or melt of a biodegradable or nonbiodegradable polymer. In another exemplary way, the active agent may be powder coated onto the surface of the filament that has been made adhesive by, e.g., heating or softening with a solvent or plasticizer. In yet another variation, microencapsulated drug may be attached to the surface of the cavity member, ostial member, and/or the nasal portion. As previously mentioned, the active agent may be incorporated throughout all portions of the device or in particular portions of the device (e.g., the cavity member and ostial member, nasal portion and cavity member, etc.).
[0100] The active agent may be included in the device such that differential release results. The differential release may be of the same active agent or for different active agents. For example, variable release of a single active agent may be achieved using methods such as bulk loading, surface coating (e.g., by having a higher load layer), surface loading (e.g., by embedding, spraying, or absorbing drug onto the device surface, etc.), and other techniques well known in the art. Variable release of different active agents may be achieved, e.g., by segmenting the drugs into different layers, reservoirs and/or microspheres, which themselves may have differing permeability or biodegradation profiles, as well as by other techniques well known in the art.
[0101] Polymers. When the devices are made with polymers, selection of the biodegradable or nonbiodegradable polymer to be employed will vary depending on the residence time and release kinetics desired, method of device delivery, particular therapeutic agent used, and the like. In all instances, the biodegradable polymer when degraded results in physiologically acceptable degradation products. The biodegradable or nonbiodegradable polymer may constitute at least about 5%, at least about 10%, at least about 20%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, or at least about 100% by weight of the device or component that it makes (e.g., sinus cavity member, ostial member, or nasal portion).
[0102] Suitable biodegradable and biocompatible polymers for use in making the paranasal sinus devices include, but are not limited to, polymers such as a poly(lactide); a poly(glycolide); a poly(lactide-co-glycolide); a poly(lactic acid); a poly(glycolic acid); a poly(lactic acid-co-glycolic acid); poly(lactide)/poly(ethylene glycol) copolymers; a poly(glycolide)/poly(ethylene glycol) copolymers; a poly(lactide-co-glycolide)/poly(ethylene glycol) copolymers; a poly(lactic acid)/poly(ethylene glycol) copolymers; a poly(glycolic acid)/poly(ethylene glycol) copolymers; a poly(lactic acid-co-glycolic acid)/poly(ethylene glycol) copolymers; a poly(caprolactone); poly(caprolactone)/poly(ethylene glycol) copolymers a poly(orthoester); a poly(phosphazene); a poly(hydroxybutyrate) or a copolymer including a poly(hydroxybutyrate); a poly(lactide-co-caprolactone); a polycarbonate; a polyesteramide; a polyanhidride; a poly(dioxanone); a poly(alkylene alkylate); a copolymer of polyethylene glycol and a polyorthoester; a biodegradable polyurethane; a poly(amino acid); a polyetherester; a polyacetal; a polycyanoacrylate; a poly(oxyethylene)/poly(oxypropylene) copolymer, or a blend or copolymer thereof. Biodegradable shape memory polymers, such as those commercialized by nmemoScience in Aachen, Germany, or those described in U.S. Pat. No. 5,189,110 or U.S. Pat. No. 5,139,832, may also be employed.
[0103] As used herein, a poly(lactide); a poly(glycolide); a poly(lactide-co-glycolide); a poly(lactic acid); a poly(glycolic acid); a poly(lactic acid-co-glycolic acid) will all be referred to as PLG, PLG polymers, or lactide/glycolide polymers. Lactide/glycolide polymers for the drug delivery devices and compositions of this invention are typically made by melt polymerization through the ring opening of lactide and glycolide monomers. Some polymers are available with or without carboxylic acid end groups. When the end group of the poly(lactide-co-glycolide), poly(lactide), or poly(glycolide) is not a carboxylic acid, for example, an ester, then the resultant polymer is referred to herein as blocked or capped. The unblocked polymer, conversely, has a terminal carboxylic group. In one variation, linear lactide/glycolide polymers are used; however, star polymers may be used as well. In other variations, high molecular weight polymers may be used to form the devices of this invention, for example, to meet strength requirements and extend bioabsorption time. In other instances, low molecular weight polymers may be used when resorption time and not material strength is important. The lactide portion of the polymer has an asymmetric carbon. Racemic DL-, L-, and D-polymers are commercially available to include in the devices of this invention. The L-polymers are more crystalline and resorb slower than DL-polymers. In addition to copolymers comprising glycolide and DL-lactide or L-lactide, copolymers of L-lactide and DL-lactide are also commercially available. Additionally, homopolymers of lactide or glycolide are commercially available. Star polymers of lactide or glycolide or lactide/glycolide copolymers are also commercially available.
[0104] In the case when the biodegradable polymer is poly(lactide-co-glycolide), poly(lactide), or poly(glycolide), the amount of lactide and/or glycolide in the polymer may vary. In one variation, the biodegradable polymer contains from about 0 to about 100 mole %, from about 40 to about 100 mole %, from about 50 to about 100 mole %, from about 60 to about 100 mole %, from about 70 to about 100 mole %, or from about 80 to about 100 mole % lactide, and from about 0 to about 100 mole %, from about 0 to about 60 mole %, from about 10 to about 40 mole %, from about 20 to about 40 mole %, or from about 30 to about 40 mole % glycolide, wherein the amount of lactide and glycolide is 100 mole %. In other variations, the biodegradable polymer may be poly(lactide), about 85:15 poly(lactide-co-glycolide), about 75:25 poly(lactide-co-glycolide), about 65:35 poly(lactide-co-glycolide), or about 50:50 poly(lactide-co-glycolide), where the ratios are mole ratios.
[0105] In another variation, when the biodegradable polymer is poly(lactide-co-glycolide), poly(lactide), or poly(glycolide), the polymer has an intrinsic viscosity of from about 0.15 to about 1.5 dL/g, from about 0.25 to about 1.5 dL/g, from about 0.25 to about 1.0 dL/g, from about 0.25 to about 0.8 dL/g, from about 0.25 to about 0.6 dL/g, or from about 0.25 to about 0.4 dL/g as measured in chloroform at a concentration of 0.5 g/dL at 30° C.
[0106] If a nonbiodegradable polymer is used to make or incorporate into the device or composition, suitable nonbiodegradable polymers include, but are not limited to, poly(ethylene vinyl acetate), poly(vinyl acetate), silicone polymers, polyurethanes, polysaccharides such as a cellulosic polymers and cellulose derivatives, acyl substituted cellulose acetates and derivatives thereof, copolymers of poly(ethylene glycol) and poly(butylene terephthalate), polystyrenes, polyvinyl chloride, polyvinyl fluoride, poly(vinyl imidazole), chorosulphonated polyolefins, polyethylene oxide, and copolymers and blends thereof.
[0107] Furthermore, the devices may be made from any biocompatible, biodegradable or nonbiodegradable polymer that is mucoadhesive. In some instances, the cavity member, ostial member, and/or nasal plate may be coated with a mucoadhesive, which may or may not be a polymer. The devices may also be made from a polymer that carries a charge.
[0108] In another variation, natural polymers may be used. Representative natural polymers that may be included in the devices include, but are not limited to, proteins, such as zein, modified zein, casein, chitin, gelatin, gluten, serum albumin, or collagen, and polysaccharides, such as cellulose, dextrans, and polyhyaluronic acid. Hydrogel or sol-gel mixtures of polysaccharides are may also be employed.
[0109] Other materials. In some variations, the devices may be made from a metal. Examples of suitable metals include, but are not limited to, cobalt, chromium, nickel, platinum, stainless steel, titanium, tantalum, and any of their alloys, e.g., nickel-titanium alloys, and combinations thereof.
[0110] Additional agents. The devices and compositions of this invention may further include components such as preservatives, buffers, binders, disintegrants, lubricants, and any other excipients necessary to maintain the structure and/or function of the devices. For example, the pliable filaments may be formed to contain a plasticizer or solvent such as acetone, methyl ethyl ketone, ethyl lactate, ethyl acetate, dichloromethane, or ethyl acetate/alcohol blends that would soften the biodegradable or nonbiodegradable polymer of the device. The plasticizer or solvent would diffuse or otherwise be released from the device into the sinus mucosa after deployment and expansion of the cavity member to harden the polymeric filaments (of the device) such that the device substantially conforms to the shape of the sinus cavity, and to the extent that a better friction fit of the cavity member against the sinus cavity wall is provided.
[0111] Furthermore, as previously described, the pliable filaments may also include a mucoadhesive polymer to enhance contact of the cavity member to the sinus mucosa. Examples of mucoadhesive polymers that may be employed include homopolymers of acrylic acid monomers such as polyacrylic acid and any of its pharmaceutically acceptable salts; copolymers of acrylic acid and methacrylic acid, styrene, or vinyl ethers; vinyl polymers such as polyhydroxyethyl acrylate, polyhydroxyethyl methacrylate, polyvinyl alcohol, and polyvinyl pyrrolidone; cellulosic derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and carboxymethyl cellulose; polysaccharides such as alginic acid, sodium alginate, and tragacanth gum; collagen; gelatin; and any combination thereof.
[0112] Release kinetics. The devices described here may be formulated with particles of an active agent dispersed or dissolved within a biodegradable polymer matrix, and formulated to provide sustained release of the active agent. If made from a non-swellable polymer, e.g., lactide/glycolide polymers, release of the active agent from the matrix is most likely achieved by erosion of the biodegradable polymer matrix and/or by diffusion of the active agent into the mucous layer of the sinus. Factors that may influence the release kinetics include such characteristics as the size of the active agent particles, the solubility of the active agent, the ratio of active agent to polymer(s), the porosity of the polymer, the method of device manufacture, the exposed surface area of the device, the surface area to volume ratio of the device, and the erosion rate of the matrix polymer(s).
[0113] The active agent may be released from the device over a prolonged time period including, but not limited to, at least about one week, at least about two weeks, at least about three weeks, or at least about four weeks, at least about two months, at least about three months, at least about four months, at least about five months, or at least about six months or more. In one variation, the therapeutic agent is released over about two weeks to about four weeks.
[0114] The drug release profile of the paranasal sinus devices may be adjusted by various techniques, such as through use of different drug, polymer, and excipient formulations or adjustment of their amounts in the formulations, use of release and drug barrier layers, differential bead, microsphere, or microcapsule constructions (with shells of varying molecular weights or thicknesses), and the like, as is well known in the art. The duration of release can also be adjusted through polymer blending ratios, monomer average molecular weights, and coatings.
[0115] As previously mentioned, differential release of the drug(s) may also be effected. The differential release may be of the same active agent or for different active agents. For example, variable release of a single active agent may be achieved using methods such as bulk loading, surface coating (e.g., by having a higher load layer), surface loading (e.g., by embedding, spraying, or absorbing drug onto the device surface, etc.), and other techniques well known in the art. Variable release of different active agents may be achieved, e.g., by segmenting the drugs into different layers, reservoirs and/or microspheres, as well as by other techniques well known in the art.
[0116] Delayed drug release, as shown in FIG. 24A is useful for adjunctive therapy, as when tapering off of intravenous or oral steroids previously given to a patient, or when releasing anti-scarring and anti-restenosis agents later in the healing process.
[0117] Substantially zero order drug release, as shown in FIG. 24B is useful for chronic disease maintenance therapy without trauma or scarring, or for anti-infective agent courses of therapy, providing a constant equilibrium concentration of drug and maximizing receptor target occupation levels.
[0118] Upfront bolus drug release, as shown in FIG. 24C during the first five to ten days is useful for treatment of post-surgical or implant insertion trauma and for creating maximum diffusion into the adjacent surgical anatomy.
[0119] Delayed bolus drug release, as shown in FIG. 24D is useful in post-operative treatment, particularly amelioration of trauma in post-operative debridement therapy.
[0120] Degradation dependent release, as shown in FIG. 24E , increasing as the device is fully bioabsorbed, is useful for prevention of any implant/device elimination trauma or complications due to bioabsorption.
[0121] Combinations are possible of any of the above drug release curves by integrating various drug release methods (for one or more drugs) in a single device. For example, as illustrated in FIG. 24F , a combination of an initial bolus, followed by substantially zero order release, followed by a final release burst is particularly useful in post-surgical application of the device, treating surgical and implantation trauma (initial bolus) then surgical healing and disease recurrence (substantially zero order), and ultimately any implant elimination trauma (final release burst).
[0122] Applications.
[0123] Therapeutic action of device. The structure of the paranasal sinus device itself may also have a therapeutic function. For example, the device may provide such functions as fixation or splinting tissue via space filling, fastening, deflection, in order to provide support and to keep a body structure open, as in stenting or packing to prevent the lateralization of the middle turbinate and occlusion of the middle meatus, or by providing a physical barrier to adhesions which may form between various post-surgical and/or inflamed tissue surfaces. For example, any device incorporating a solid, semi-solid (gel) or woven or nonwoven mesh structure could be used to practice this method. In another variation, the device may non-occlusively maintain patency through the implant feature area providing the device action by direct provision and maintenance of a channel, fenestration or port from the sinuses to the infundibulum, osteomeatal complex, meatus or nasal passage by which mucociliary flow may travel. Such a channel may be within and support the structure of natural ostia or within and support a surgically created or modified antrostomy to the sinus, but may not totally occlude such openings. For example, any device with a lumen or pore such as a tube or cannula, or stent with a lumen, could be used to practice this method, as could a highly porous packing material, three dimensional mesh, or surface or interior structured device through which mucus can flow and which does not become occlusive of the provided channel through absorbancy, expansion, or degradation.
[0124] Reduction of complications upon implantation. In yet another variation, the device may possess a structural feature or active agent that helps to reduce the complications of device implantation. For example, the device may: 1) prevent trauma due to device removal by use of bioabsorbable materials; 2) prevent biofilm formation by use of coatings, physical surface treatments, and/or incorporation or elution of an anti-infective or antiseptic substance; 3) prevent foreign body reactions by incorporating low-dose anti-inflammatory substances including steroidal and non-steroidal anti-inflammatories (for example, including the anti-inflammatory effects of low dose macrolide antibiotics); and 4) prevent device migration by specific active or passive fixation and anchoring features incorporated in the device. Substances that may be used to prevent biofilm formation include, but are not limited to, alcohol, chlorhexidine, iodine, triclosan, hexachlorophene, and silver-based agents (e.g., silver chloride, silver oxide, silver nanoparticles). In other variations, the surface of the device may treated by a process (e.g. ion embedding, plasma etching, etc.) altering the physical properties of the surface of the device in order to prevent biofilm formation.
[0125] Exploitation of mucociliary clearance. Normal mucociliary clearance may be used to extend drug diffusion and effect beyond the physical location of the device. This is useful in both normal and particularly diseased mucociliary flow patterns. In the later case, the device is useful in effecting the build up of therapeutically desirable concentrations of released drug at blockages when the normal mucociliary flow is interrupted or impeded by disease, and increasing drug concentration gradients where mucociliary function is most impacted by disease. Anatomical blockages and areas of mucociliary dysfunction or ciliary dysmotility may be particularly desirable areas of such drug treatments (e.g., anti-inflammatories and anti-infectives, but also including chemotherapeutic agents), so as to “chemically open” the blockage and to increase treatment of the damaged mucosa. Thus, the natural sinus and upstream locations along the mucociliary clearance pathway may serve as drug depots, with drug traveling to desired sites downstream in the pathway. This contrasts with previous and current teachings in the field which seek to impede or reduce mucociliary clearance of active agents in order to maximize dose duration.
[0126] In addition to treating any one of the aforementioned paranasal sinus conditions, the devices described herein may be placed during, or as an adjunct to, a surgical, non-surgical, or other therapeutic intervention of the sinuses or nasal passages. For example, the device may be used during or as an adjunt to such procedures including, but not limited to, septoplasty (surgical removal or adjustment of the nasal septum); turbinoplasty (surgical removal or adjustment of the turbinate bones); rhinoplasty generally; sinus surgery (including the exploration, revision, repair, tissue dissection or removal of some or part of any of the sinuses, including the ethmoid sinuses (as in ethmoidectomy), maxillary sinuses, frontal sinuses, or sphenoid sinuses); polyp removal in any part of the paranasal sinuses and nasal passages; cannulation, irrigation, and therapy instillation or injection of any of the above sinuses or the nasal passages, including through nasal, trans-ostial, and external puncture approaches (such as through antral puncture, trephination or “Caldwell-Luc” procedures); surgical revision, dissection, reconstruction or repair of the anatomy of the paranasal sinuses and nasal passages, including any removal or adjustment of neoplasms, foreign bodies, lesions, adhesions, defects, stenosis, and fistula of the natural or post-surgical anatomy; ligation, cauterization, and ablation procedures to control nasal bleeding and repair vasculature in the anatomy of the paranasal sinuses and nasal passages, or as an adjunct or technique to perform any such surgical or non-surgical procedure.
[0127] Thus, the devices described here may have a variety of functions. For example, they may deliver an active agent to treat rhinosinusitis, have a structure that prevents lateralization of the middle turbinate and formation of adhesions, have a structure which directly or indirectly preserves ostial patency, as well as have a coating that prevents biofilm formation. The devices may be formed to include any number and combination of functions listed above.
[0128] Delivery devices and methods of use. The paranasal sinus devices may be placed into the sinus using various types of sinus inserters. The inserter may include a conduit, e.g., a catheter with a lumen. The conduit may be flexible or rigid, or may be designed to have varying degrees of stiffness along its length, e.g., the distal portion of the conduit may be stiffer than the proximal portion. In addition, the distal portion of the conduit may be variously angulated to facilitate positioning and advancement of the conduit through the sinus ostium. For example, the distal portion may be angulated from about 0° to about 175°, from about 0° to about 135°, or from about 0° to about 90°. If desired, the distal portion of the conduit may also be formed to be malleable.
[0129] The conduit may be made from any biocompatible material including, but not limited to, stainless steel and any of its alloys; titanium alloys, e.g., nickel-titanium alloys; polymers, e.g., polyethylene and copolymers thereof, polyethylene terephthalate or copolymers thereof, nylon, silicone, polyurethanes, fluoropolymers, poly(vinylchloride), and combinations thereof, depending on the amount of flexibility or stiffness desired.
[0130] The inserter may be preloaded with a single paranasal sinus device on or within the distal end of the conduit, but more than one device may be preloaded if desired. It may be preloaded on or within the inserter by the physician prior to insertion or preloaded on or within the inserter during the manufacturing process. Once access through a sinus ostium or surgically created fenestration has been obtained with the conduit, the sheath may be retracted to slidably deploy the nasal portion of the device. If the cavity member is self-expanding, then retraction of a sheath also causes the cavity member to be deployed. If expansion using a balloon is required, any balloon catheter (including double balloon catheters) known in the art may be advanced through the lumen in the conduit until the balloon lies within the cavity member. Inflation of the balloon thereby causes the cavity member to change from a first collapsed configuration to a second expanded configuration and contact the sinus cavity wall. An endoscope may also be used while positioning the inserter to aid with visualization of the ostium. Irrigation tools and electrocautery may also be employed if needed.
[0131] The following description provides an exemplary way of a how a single device might be deployed into a sinus using a sinus inserter. The sinus inserter typically includes a distal portion, a sinus device in its collapsed configuration on the distal portion, a handle, a conduit having a lumen, and a sheath connected to a retractable knob. Upon pulling the retractable knob, the knob moves proximally to abut the handle and slidably deploy the self-expanding nasal plate of the device. A balloon catheter may then be advanced through the lumen of the conduit into the distal portion of the inserter and inflated to expand the sinus device, such as the flexible mesh 40 of FIGS. 4A-4B .
[0132] Method of manufacture. The method of preparing the devices of this invention will generally depend on the particular active agent or polymer used, form of the cavity member, and the release kinetics desired, but may be made by any one of the numerous methods known in the art. For example, the devices may be made by such processes as extrusion; injection or form molding; blow, film, or melt casting; welding; and other manufacturing techniques well known in the art (e.g., cutting and annealing). The filaments may be wet or melt spun, formed by laser or other cutting, formed by slitting, formed by extrusion, injection or other molding, or casting.
EXAMPLES
[0133] The following examples serve to more fully describe the manner of making and using the above-described devices. It is understood that these examples in no way serve to limit the scope of this invention, but rather are presented for illustrative purposes.
[0134] Furthermore, the following examples will employ, unless otherwise indicated, conventional techniques of pharmaceutical formulation, medicinal chemistry, and the like, which are within the skill of the art. Such techniques are explained fully in the literature. Efforts have been made to ensure accuracy with respect to numbers (e.g., amounts, temperature, etc.), but some experimental error and deviation should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in degrees Celsius (° C.) and pressure is at or near atmospheric pressure at sea level. All components are obtainable commercially unless otherwise indicated.
Example 1
Melt Extrusion of Fiber Containing 5 wt % Mometasone Furoate
[0135] Extruded ribbon fiber was made with mometasone furoate and poly(DL-lactide-co-glycolide). The desired mometasone furoate content in the device was 5 wt % mometasone furoate. The poly(DL-lactide-co-glycolide) was ester capped with a molar ratio of 70/30 DL-lactide/glycolide and had an inherent viscosity of 0.81 dL/g. The inherent viscosity was measured at 30° C. with 0.5 gm/dL polymer concentration in chloroform.
[0136] First mometasone furoate (0.5 gm) and the poly(DL-lactide-co-glycolide) (9.5 gm) were dissolved in methylene chloride (40 gm). A thin film was cast from the resulting solution. The cast film was dried in a vacuum oven for 48-96 hours to remove residual methylene chloride. The cast film was cut into thin strips approximately 10-20 mm wide and 100-150 mm long. Next a Tinius Olsen Model UE-4-78 melt plastometer was used to extrude the cast film strips. The Tinius Olsen is a solid block of steel about 80 mm in diameter and about 160 mm high/long with a hollow core about 13 mm in diameter. The discharge of the core has a shoulder that allows different size “dies” to be used based on the desired diameter of extruded rod. For this run, a custom machined die was used with internal core dimensions of 0.3556 mm×2.0015 mm. The main block of the Tinius Olsen has heater bands encased by insulation and a shroud that allow the Tinius Olsen to be heated to a desired temperature. A thermocouple was used to measure the temperature of the block. The control system then uses the thermocouple values to either turn the heater bands on or off. Throughout the extrusion process, the heater bands will switch off and on to maintain the desired temperature. The cast film strips, approximately 4 gm, were loaded into the Tinius Olsen which had been equilibrated to 120° C. A charging rod was placed in the core of the Tinius Olsen to compress the blend and a weight of 10 kg was placed oh the end of the charging rod to aid in the compaction of the blend. The equilibration time for the blend to melt lasted for about 20 minutes. After an extrusion load of 10,000 gm was placed on the charging rod, the plug was removed from the discharge area to begin the extrusion run. As the ribbon fiber was extruded from the discharge, it was pulled using a conveyor belt to the desired dimensions (0.3-0.4 mm×1.0-1.2 mm). The 4-gm charge afforded 7-10 segments of extruded fiber each having a length of about 100 cm.
Example 2
Melt Extrusion of Fiber Containing 5 wt % Mometasone Furoate and 2 wt % Triethyl Citrate
[0137] Extruded ribbon fiber was made with mometasone furoate, triethyl citrate (plasticizer) and poly(DL-lactide-co-glycolide). The desired mometasone furoate content in the device was 5 wt % mometasone furoate. The poly(DL-lactide-co-glycolide) was ester capped with a molar ratio of 70/30 DL-lactide/glycolide and had an inherent viscosity of 0.81 dL/g. The inherent viscosity was measured at 30° C. with 0.5 gm/dL polymer concentration in chloroform.
[0138] First mometasone furoate (0.5 gm), triethyl citrate (0.2 gm) and the poly(DL-lactide-co-glycolide) (9.3 gm) were dissolved in ethyl acetate (40 gm). A thin film was cast from the resulting solution. The cast film was dried in a vacuum oven for 48-96 hours to remove residual methylene chloride. The cast film was cut into thin strips approximately 10-20 mm wide and 100-150 mm long. Next a Tinius Olsen Model UE-4-78 melt plastometer was used to extrude the cast film strips. The Tinius Olsen is a solid block of steel about 80 mm in diameter and about 160 mm high/long with a hollow core about 13 mm in diameter. The discharge of the core has a shoulder that allows different size “dies” to be used based on the desired diameter of extruded rod. For this run, a custom machined die was used with internal core dimensions of 0.3556 mm×2.0015 mm. The main block of the Tinius Olsen has heater bands encased by insulation and a shroud that allow the Tinius Olsen to be heated to a desired temperature. A thermocouple was used to measure the temperature of the block. The control system then used the thermocouple values to either turn the heater bands on or off. Throughout the extrusion process, the heater bands switched off and on to maintain the desired temperature. The cast film strips, approximately 4 gm, were loaded into the Tinius Olsen which had been equilibrated to 120° C. A charging rod was placed in the core of the Tinius Olsen to compress the blend and a weight of 10 kg was placed on the end of the charging rod to aid in the compaction of the blend. The equilibration time for the blend to melt lasted for about 20 minutes. After an extrusion load of 10,000 gm was placed on the charging rod, the plug was removed from the discharge area to begin the extrusion run. As the ribbon fiber was extruded from the discharge, it was pulled using a conveyor belt to the desired dimensions (0.3-0.4 mm×1.0-1.2 mm). The 4-gm charge afforded 7-10 segments of extruded fiber each having a length of about 100 cm.
[0139] Various compositions of ribbon fiber were made following fabrication techniques similar to those described in Examples 1 and 2. Table 1 below lists these formulation compositions having varying amounts of mometasone furoate, plasticizers, and porosigens and showing the use of different processing solvents (ethyl acetate and methylene chloride) to prepare material to place into an extruder.
[0140]
| TABLE 1 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Compositions of ribbon fibers prepared by melt extrusion | ||||||||||
| Batch | Plasticizer | Porosigen | Fiber Dimensions | |||||||
| Batch | Size | Polymer | Mometasone | Content | Content | Thickness | Width | |||
| Number | (g) | (DL-PLG) | Load (wt %) | Processing Solvent | Plasticizer | (wt %) | Porosigen | (wt %) | (mm) | (mm) |
| 0015-50 | 5 | 69:31 | 2 | Ethyl Acetate | TEC | 2 | NA | 0 | 0.4 | 1.50 |
| 0015-51 | 5 | 69:31 | 2 | Ethyl Acetate | TEC | 4 | NA | 0 | 0.50 | 1.45 |
| 0015-52 | 5 | 69:31 | 5 | Ethyl Acetate | TEC | 0 | NA | 0 | 0.36 | 1.00 |
| 0015-53 | 5 | 69:31 | 5 | Ethyl Acetate | TEC | 2 | NA | 0 | 0.52 | 1.45 |
| 0015-54 | 5 | 69:31 | 5 | Ethyl Acetate | TEC | 4 | NA | 0 | 0.56 | 1.50 |
| 0015-55 | 5 | 69:31 | 10 | Ethyl Acetate | TEC | 4 | NA | 0 | 0.50 | 1.30 |
| 0015-56 | 5 | 69:31 | 10 | Ethyl Acetate | TEC | 2 | NA | 0 | 0.50 | 1.38 |
| 0065-01 | 3.9 | 69:31 | 2 | Ethyl Acetate | TEC | 2 | NA | 0 | 0.53 | 1.33 |
| 0065-02 | 3.8 | 69:31 | 5 | Ethyl Acetate | TEC | 0 | NA | 0 | 0.38 | 1.28 |
| 0065-03 | 3.9 | 69:31 | 5 | Ethyl Acetate | TEC | 2 | NA | 0 | 0.42 | 1.46 |
| 0065-09 | 3.9 | 69:31 | 2 | Ethyl Acetate | NA | 0 | NA | 0 | 0.39 | 1.25 |
| 0065-10 | 1.9 | 69:31 | 2 | Ethyl Acetate | NA | 0 | NA | 0 | 0.35 | 1.18 |
| 0065-15 | 4.2 | 69:31 | 0.5 | Ethyl Acetate | NA | 0 | NA | 0 | 0.43 | 1.37 |
| 0065-16 | 4.1 | 69:31 | 0.5 | Methylene Chloride | NA | 0 | NA | 0 | 0.35 | 1.20 |
| 0065-17 | 4.1 | 69:31 | 0.5 | Ethyl Acetate | NA | 0 | PEG 1500 | 2 | 0.42 | 1.38 |
| 0065-18 | 4.2 | 69:31 | 0.5 | Methylene Chloride | NA | 0 | PEG 1500 | 2 | 0.38 | 1.23 |
| 0065-37 | 4 | 69:31 | 5.0 | Methylene Chloride | NA | 0 | NA | 0 | 0.34 | 1.19 |
| 0065-38 | 3.9 | 69:31 | 2.0 | Methylene Chloride | NA | 0 | NA | 0 | 0.30 | 1.02 |
| 0065-39 | 4.1 | 69:31 | 0.5 | Methylene Chloride | NA | 0 | NA | 0 | 0.32 | 1.09 |
| 0065-40 | 4 | 69:31 | 0.25 | Methylene Chloride | NA | 0 | PEG 1500 | 2 | 0.39 | 1.22 |
Example 3
Fabrication of Fiber Containing 2 wt % of Fluticasone Proprionate
[0141] A fiber formulation can be made with fluticasone proprionate with poly(DL-lactide) or poly(lactide-co-glycolide). The poly(lactide) or poly(lactide-co-glycolide) can be capped or have acid end groups. The desired fluticasone proprionate content in the fiber can range from 0.1 wt % to 20 wt %. To prepare a long-acting formulation of fluticasone proprionate, particles of fluticasone proprionate and poly(DL-lactide-co-glycolide) or poly(lactide-co-glycolide) can be dry blended in a variety of ways including the use of a mortar/pestle or by mixing preformed polymer and peptide particles in a V-blender to form a blended powder. Next this blend or admixture can be added to a twin-screw extruder having a machined die with a 2-mm diameter. The temperature of the extruder should be about 120° C. As the fiber is extruded from the extruder, it will be collected on a conveyor belt.
Example 4
Fabrication of Paranasal Sinus Device with Ribbon Fiber containing 5 wt % Mometasone Furoate
[0142] Ribbon fiber as prepared by Example 1, was fabricated into a paranasal sinus device in the following manner. Four strands of ribbon fiber were cut to approximately 35 mm and then looped to form whisk-like structures as previously described.
Example 5
Quantifying Mometasone Furoate Levels in the Sinus Tissue of Rabbits During Treatment with a Mometasone Furoate Loaded Paranasal Sinus Device
[0143] Paranasal sinus devices prepared as described in Example 4 were sterilized with 2.5 Mrad of gamma radiation and placed in the maxillary sinuses (right and left sides) of 5-kg rabbits through dorsal nasal maxillary sinusotomies. Three formulations were tested. These were as follows:
-
- [0144] PLG 69:31 with 5% mometasone and 0% triethylcitrate (TEC)
- [0145] PLG 69:31 with 5% mometasone and 2% TEC
- [0146] PLG 69:31 with 10% mometasone and 2% TEC
[0147] The same formulation was used for both right and left sinuses of a given rabbit. Fifteen rabbits were implanted. Five rabbits were implanted with each device formulation. The devices were explanted at approximately weekly intervals post implantation over a 5-week period. The mucosa of both right and left maxillary sinuses was removed completely at the time of explanation. The tissue was rapidly frozen and the amount of mometasone in the tissue was quantitated by liquid chromatography/mass spectroscopy (LC/MS). The amount of mometasone maintained in the tissue over a 35-day period is reported in the table below, and is equivalent to 10−5 M to 10−7 M concentration at the desired site of action, at all time points demonstrating a sustained release and bioavailability of drug at levels of tissue concentration which are known to have therapeutic efficacy (see below).
[0148]
| Mometasone Levels Measured in Excised | ||||||
| Sinus Mucosa | ||||||
| (micrograms Mometasone per gram tissue) | ||||||
| 4 day | 14 | 25 | 30 | 35 | ||
| pooled | day | day | day | day | ||
| 10% Mometasone | R | 0.915 | 1.41 | 183 | 139 | 97.6 |
| 2% TEC | L | 0.823 | 5.95 | 7.57 | 152 | 335 |
| 5% Mometasone | R | 1.17 | 1.01 | 1.44 | 0.76 | 81.7 |
| 2% TEC | L | (st dev = | No peak | 44.3 | 86.4 | 153 |
| 5% Mometasone | R | 0.18) | 246 | 1.28 | 2.11 | 178 |
| 0% TEC | L | 2.57 | 0.54 | 158 | ||
Example 6
In Vitro Release of Mometasone Furoate From Candidate Compositions
[0149] The in vitro release of mometasone furoate from candidate formulations was determined, and is shown in FIG. 25 . To carry out this in vitro release study, each device was placed at 37° C. in 1.0 wt % sodium dodectyl sulfate (SDS) in nanopure water, the receiving fluid. At each time point, the receiving fluid was removed completely and fresh receiving fluid was added. The amount of mometasone released into the receiving at each time point was quantified by HPLC.
[0150] In a first in vitro cumulative release study, as shown in FIG. 25 , cumulative release of mometasone furoate from a 2% mometasone/4% TEC fiber was about 6% at day 7, about 11% at day 14, about 14% at day 21, and about 15% at day 28. For the 5% mometasone/0% TEC fiber, cumulative mometasone release was about 4% at day 7, about 10% at day 14, about 12% at day 21, and about 12 at day 28. The 5% mometasone/2% TEC fiber cumulative mometasone release was about 3% at day 7, about 7% at day 14, about 9% at day 21, and about 9% at day 28. For the 10% mometasone/2% TEC fiber, cumulative mometasone release measured to be about 4% at day 7, 9% at day 14, 12% at day 21, and 12% at day 28. Additional drug release due to in vivo polymer biodegradation and clearance was demonstrated and directly observed as described above in the tissue concentration data.
[0151] Published in vitro cellular models using cultured human airway epithelial cells indicate drug concentration dose response curves for the most potent glucocorticoids, mometasone furoate and fluticasone propionate, beginning as low as 10−12 M (picomolar) and EC50 levels of transcriptional response at 10−10 M (100 picomolar; maximal transcriptional response was seen in most cases by 10−9 M (nanomolar) drug concentrations). These in vitro models have been accepted as equivalent to and highly correlated with in vivo models of efficacy (Romestan C. et al Fluticasone Propionate and Mometasone Furoate Have Equivalent Transcriptional Potencies, Clin Exp Allergy 2003; 33: 895-901).
[0152] All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes to the same extent as if each individual publication, patent, or patent application were specifically and individually indicated to be so incorporated by reference. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit and scope of the appended claims.
Claims
What is claimed as new and desired to be protected by Letters Patent of the United States is:
1. A system for treating a paranasal sinus condition comprising:
a) an introducer; and
b) a fully implantable, bioabsorable, paranasal sinus device comprising
a first member and a plurality of prongs, each prong having a proximal end extending from a distal end of the first member and a free distal end, wherein the first member and plurality of prongs are made of a bioabsorbable polymer, and
an active agent configured to release therefrom;
wherein the device has a first configuration wherein the plurality of prongs is collapsed to permit the device to pass through a sinus ostium or surgically created fenestration and a second expanded configuration after placement into a sinus cavity.
2. The system of claim 1 wherein the introducer comprises a conduit having a lumen and a distal portion, and wherein the paranasal sinus device is placed within the lumen or is releasably secured to the distal portion of the introducer.
3. The system of claim 2 further comprising a sheath.
4. The system of claim 3 wherein the paranasal sinus device is delivered into the sinus cavity by retracting the sheath to deploy the first member and expand the plurality of prongs.
5. The system of claim 2 wherein the introducer is preloaded with the paranasal sinus device.
6. The system of claim 1 wherein the paranasal sinus condition is sinus inflammation due to functional endoscopic sinus surgery (FESS).
7. A method for treating a paranasal sinus condition comprising:
fully implanting a paranasal sinus device within a patient, wherein the paranasal sinus device comprises
a first member and a plurality of prongs, each prong having a proximal end extending from a distal end of the first member and a free distal end, wherein the first member and plurality of prongs are made of a bioabsorbable polymer,
and an active agent configured to release therefrom;
wherein the plurality of prongs expand to contact surrounding tissue in the paranasal sinus when the device is fully implanted.
8. The method of claim 7 wherein the paranasal sinus device releases the active agent to treat the paranasal sinus condition for about one week.
9. The method of claim 7 wherein the paranasal sinus device releases the active agent to treat the paranasal sinus condition for about two weeks.
10. The method of claim 7 wherein the paranasal sinus device releases the active agent to treat the paranasal sinus condition for about three weeks.
11. The method of claim 7 wherein the paranasal sinus device releases the active agent to treat the paranasal sinus condition for about one month.
12. The system of claim 2 wherein the paranasal sinus device is delivered into the sinus cavity by advancing a pusher through the conduit lumen.
13. The system of claim 1 wherein the paranasal sinus device is releasably secured to the introducer.
14. The system of claim 1 wherein the introducer is malleable.
15. The system of claim 1 wherein the paranasal sinus condition is sinus inflammation.
16. The method of claim 7 wherein the active agent is included in a coating on the device.
17. The method of claim 16 wherein the plurality of prongs comprises one or more anchoring elements.
Patent Citations (257)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US2691985(A) | 1954-10-01 | Newsom | Examiner |
| US3049125(A) | 1962-08-01 | Kriwkowitsch | Examiner |
| US3502078(A) | 1970-03-01 | Hill et al. | Applicant |
| US3570494(A) | 1971-03-01 | Gottschalk | Examiner |
| US3766924(A) | 1973-10-01 | Pidgeon | Examiner |
| US3800788(A) | 1974-04-01 | White | Applicant |
| US3894539(A) | 1975-07-01 | Tallent | Examiner |
| US3903893(A) | 1975-09-01 | Scheer | Examiner |
| US4389208(A) | 1983-06-01 | LeVeen et al. | Examiner |
| US4419095(A) | 1983-12-01 | Nebergall et al. | Applicant |
| US4580568(A) | 1986-04-01 | Gianturco | Applicant |
| US4737141(A) | 1988-04-01 | Spits | Examiner |
| US4753636(A) | 1988-06-01 | Free | Applicant |
| US4941881(A) | 1990-07-01 | Masters et al. | Examiner |
| US5011474(A) | 1991-04-01 | Brennan | Examiner |
| US5035706(A) | 1991-07-01 | Giantureo et al. | Applicant |
| US5116311(A) | 1992-05-01 | Löfstedt | Applicant |
| US5139832(A) | 1992-08-01 | Hayashi et al. | Applicant |
| US5189110(A) | 1993-02-01 | Ikematu et al. | Applicant |
| US5246455(A) | 1993-09-01 | Shikani | Applicant |
| US5342296(A) | 1994-08-01 | Persson et al. | Applicant |
| US5348553(A) | 1994-09-01 | Whitney | Examiner |
| US5443498(A) | 1995-08-01 | Fontaine | Applicant |
| US5512055(A) | 1996-04-01 | Domb et al. | Applicant |
| US5538738(A) | 1996-07-01 | Ritter et al. | Applicant |
| US5632762(A) | 1997-05-01 | Myler | Applicant |
| US5664567(A) | 1997-09-01 | Linder | Applicant |
| US5672179(A) | 1997-09-01 | Garth et al. | Examiner |
| US5693065(A) | 1997-12-01 | Rains, III | Applicant |
| US5746224(A) | 1998-05-01 | Edwards | Applicant |
| US5792100(A) | 1998-08-01 | Shantha | Applicant |
| US5800379(A) | 1998-09-01 | Edwards | Examiner |
| US5800429(A) | 1998-09-01 | Edwards | Examiner |
| US5928190(A) | 1999-07-01 | Davis | Applicant |
| US6033436(A) | 2000-03-01 | Steinke et al. | Applicant |
| US6054122(A) | 2000-04-01 | MacPhee et al. | Applicant |
| US6092528(A) | 2000-07-01 | Edwards | Examiner |
| US6123697(A) | 2000-09-01 | Shippert | Examiner |
| US6149944(A) | 2000-11-01 | Jeong et al. | Applicant |
| US6190353(B1) | 2001-02-01 | Makower et al. | Examiner |
| US6195225(B1) | 2001-02-01 | Komatsu et al. | Examiner |
| US6200335(B1) | 2001-03-01 | Igaki | Examiner |
| US6224626(B1) | 2001-05-01 | Steinke | Applicant |
| US6228111(B1) | 2001-05-01 | Törmälä et al. | Applicant |
| US6297227(B1) | 2001-10-01 | Johnson | Applicant |
| US6302875(B1) | 2001-10-01 | Makower et al. | Examiner |
| US6306084(B1) | 2001-10-01 | Pinczower | Examiner |
| US6342068(B1) | 2002-01-01 | Thompson | Applicant |
| US6350465(B1) | 2002-02-01 | Jonnalagadda et al. | Examiner |
| US6355032(B1) | 2002-03-01 | Hovda et al. | Examiner |
| US6375615(B1) | 2002-04-01 | Flaherty et al. | Examiner |
| US6491940(B1) | 2002-12-01 | Levin | Examiner |
| US6537294(B1) | 2003-03-01 | Boyle et al. | Examiner |
| US6543452(B1) | 2003-04-01 | Lavigne | Applicant |
| US6544230(B1) | 2003-04-01 | Flaherty et al. | Examiner |
| US6555566(B2) | 2003-04-01 | Ponikau | Applicant |
| US6565597(B1) | 2003-05-01 | Fearnot et al. | Applicant |
| US6685648(B2) | 2004-02-01 | Flaherty et al. | Examiner |
| US6715485(B1) | 2004-04-01 | Djupesland | Examiner |
| US6719934(B2) | 2004-04-01 | Stinson | Applicant |
| US6746426(B1) | 2004-06-01 | Flaherty et al. | Examiner |
| US6749617(B1) | 2004-06-01 | Palasis et al. | Applicant |
| US6884260(B2) | 2005-04-01 | Kugler et al. | Applicant |
| US6945992(B2) | 2005-09-01 | Goodson, IV et al. | Applicant |
| US6951053(B2) | 2005-10-01 | Padilla et al. | Applicant |
| US6966923(B2) | 2005-11-01 | Gittings | Applicant |
| US7018401(B1) | 2006-03-01 | Hyodoh et al. | Applicant |
| US7074426(B2) | 2006-07-01 | Kochinke | Examiner |
| US7108706(B2) | 2006-09-01 | Hogle | Examiner |
| USRE39321(E) | 2006-10-01 | MacPhee et al. | Applicant |
| US7195016(B2) | 2007-03-01 | Loyd et al. | Examiner |
| US7361168(B2) | 2008-04-01 | Makower et al. | Applicant |
| US7410480(B2) | 2008-08-01 | Muni et al. | Applicant |
| US7419497(B2) | 2008-09-01 | Muni et al. | Applicant |
| US7462175(B2) | 2008-12-01 | Chang et al. | Applicant |
| US7500971(B2) | 2009-03-01 | Chang et al. | Applicant |
| US7520876(B2) | 2009-04-01 | Ressemann et al. | Examiner |
| US7544192(B2) | 2009-06-01 | Eaton et al. | Applicant |
| US7559925(B2) | 2009-07-01 | Goldfarb et al. | Applicant |
| US7641644(B2) | 2010-01-01 | Chang et al. | Applicant |
| US7645272(B2) | 2010-01-01 | Chang et al. | Applicant |
| US7654997(B2) | 2010-02-01 | Makower et al. | Applicant |
| US7658758(B2) | 2010-02-01 | Diaz et al. | Applicant |
| US7662141(B2) | 2010-02-01 | Eaton et al. | Applicant |
| US7662142(B2) | 2010-02-01 | Eaton et al. | Applicant |
| US7686798(B2) | 2010-03-01 | Eaton et al. | Applicant |
| US7691094(B2) | 2010-04-01 | Eaton et al. | Applicant |
| US7713255(B2) | 2010-05-01 | Eaton et al. | Applicant |
| US7717933(B2) | 2010-05-01 | Becker | Applicant |
| US7740642(B2) | 2010-06-01 | Becker | Applicant |
| US7753929(B2) | 2010-07-01 | Becker | Applicant |
| US2002/0051793(A1) | 2002-05-01 | Drabick | Applicant |
| US2002/0111603(A1) | 2002-08-01 | Cheikh | Applicant |
| US2002/0143387(A1) | 2002-10-01 | Soetikno et al. | Applicant |
| US2002/0188344(A1) | 2002-12-01 | Bolea et al. | Applicant |
| US2002/0198586(A1) | 2002-12-01 | Inoue | Applicant |
| US2003/0133877(A1) | 2003-07-01 | Levin | Applicant |
| US2003/0135970(A1) | 2003-07-01 | Thornton | Applicant |
| US2003/0147954(A1) | 2003-08-01 | Yang et al. | Applicant |
| US2003/0195459(A1) | 2003-10-01 | Shippert | Applicant |
| US2003/0203030(A1) | 2003-10-01 | Ashton et al. | Applicant |
| US2003/0209835(A1) | 2003-11-01 | Chun et al. | Applicant |
| US2004/0043052(A1) | 2004-03-01 | Hunter et al. | Examiner |
| US2004/0064083(A1) | 2004-04-01 | Becker | Examiner |
| US2004/0116958(A1) | 2004-06-01 | Gopferich et al. | Applicant |
| US2004/0133270(A1) | 2004-07-01 | Grandt | Applicant |
| US2005/0043706(A1) | 2005-02-01 | Eaton et al. | Applicant |
| US2005/0131525(A1) | 2005-06-01 | Hartley | Applicant |
| US2005/0203605(A1) | 2005-09-01 | Dolan | Applicant |
| US2005/0229670(A1) | 2005-10-01 | Perreault | Applicant |
| US2005/0240147(A1) | 2005-10-01 | Makower et al. | Applicant |
| US2005/0245906(A1) | 2005-11-01 | Makower et al. | Applicant |
| US2006/0004286(A1) | 2006-01-01 | Chang et al. | Applicant |
| US2006/0004323(A1) | 2006-01-01 | Chang et al. | Applicant |
| US2006/0063973(A1) | 2006-03-01 | Makower et al. | Applicant |
| US2006/0095066(A1) | 2006-05-01 | Chang et al. | Applicant |
| US2006/0106361(A1) | 2006-05-01 | Muni et al. | Applicant |
| US2006/0142736(A1) | 2006-06-01 | Hissink et al. | Applicant |
| US2006/0162722(A1) | 2006-07-01 | Boehm et al. | Applicant |
| US2006/0210605(A1) | 2006-09-01 | Chang et al. | Applicant |
| US2006/0265042(A1) | 2006-11-01 | Catanese, III et al. | Applicant |
| US2006/0276871(A1) | 2006-12-01 | Lamson et al. | Applicant |
| US2007/0100435(A1) | 2007-05-01 | Case et al. | Applicant |
| US2007/0129751(A1) | 2007-06-01 | Muni et al. | Applicant |
| US2007/0131525(A1) | 2007-06-01 | Lu et al. | Applicant |
| US2007/0135789(A1) | 2007-06-01 | Chang et al. | Applicant |
| US2007/0167682(A1) | 2007-07-01 | Goldfarb et al. | Applicant |
| US2007/0191922(A1) | 2007-08-01 | Hartley | Applicant |
| US2007/0207186(A1) | 2007-09-01 | Scanlon et al. | Applicant |
| US2007/0208252(A1) | 2007-09-01 | Makower | Applicant |
| US2007/0208301(A1) | 2007-09-01 | Evard et al. | Applicant |
| US2007/0249896(A1) | 2007-10-01 | Goldfarb et al. | Applicant |
| US2007/0250105(A1) | 2007-10-01 | Ressemann et al. | Applicant |
| US2007/0269385(A1) | 2007-11-01 | Yun et al. | Applicant |
| US2007/0282305(A1) | 2007-12-01 | Goldfarb et al. | Applicant |
| US2007/0293726(A1) | 2007-12-01 | Goldfarb et al. | Applicant |
| US2007/0293727(A1) | 2007-12-01 | Goldfarb et al. | Applicant |
| US2007/0293946(A1) | 2007-12-01 | Gonzales et al. | Applicant |
| US2008/0015540(A1) | 2008-01-01 | Muni et al. | Applicant |
| US2008/0058295(A1) | 2008-03-01 | Chaudry | Applicant |
| US2008/0058296(A1) | 2008-03-01 | Chaudry | Applicant |
| US2008/0069858(A1) | 2008-03-01 | Weber | Applicant |
| US2008/0077226(A1) | 2008-03-01 | Ouellette et al. | Applicant |
| US2008/0077230(A1) | 2008-03-01 | Heaney et al. | Applicant |
| US2008/0082162(A1) | 2008-04-01 | Boismier et al. | Applicant |
| US2008/0085293(A1) | 2008-04-01 | Yang | Applicant |
| US2008/0089952(A1) | 2008-04-01 | Hunter et al. | Applicant |
| US2008/0097154(A1) | 2008-04-01 | Makower et al. | Applicant |
| US2008/0097239(A1) | 2008-04-01 | Chang et al. | Applicant |
| US2008/0097295(A1) | 2008-04-01 | Makower et al. | Applicant |
| US2008/0097400(A1) | 2008-04-01 | Chang et al. | Applicant |
| US2008/0097514(A1) | 2008-04-01 | Chang et al. | Applicant |
| US2008/0097515(A1) | 2008-04-01 | Chang et al. | Applicant |
| US2008/0097516(A1) | 2008-04-01 | Chang et al. | Applicant |
| US2008/0097568(A1) | 2008-04-01 | Savage et al. | Applicant |
| US2008/0097575(A1) | 2008-04-01 | Cottone | Applicant |
| US2008/0097576(A1) | 2008-04-01 | Cottone et al. | Applicant |
| US2008/0097580(A1) | 2008-04-01 | Dave | Applicant |
| US2008/0097581(A1) | 2008-04-01 | Shanley | Applicant |
| US2008/0097591(A1) | 2008-04-01 | Savage et al. | Applicant |
| US2008/0103361(A1) | 2008-05-01 | Makower et al. | Applicant |
| US2008/0103521(A1) | 2008-05-01 | Makower et al. | Applicant |
| US2008/0113000(A1) | 2008-05-01 | Hunter et al. | Applicant |
| US2008/0119693(A1) | 2008-05-01 | Makower et al. | Applicant |
| US2008/0125626(A1) | 2008-05-01 | Chang et al. | Applicant |
| US2008/0125720(A1) | 2008-05-01 | Kim et al. | Applicant |
| US2008/0132938(A1) | 2008-06-01 | Chang et al. | Applicant |
| US2008/0145514(A1) | 2008-06-01 | Hunter et al. | Applicant |
| US2008/0154237(A1) | 2008-06-01 | Chang et al. | Applicant |
| US2008/0154250(A1) | 2008-06-01 | Makower et al. | Applicant |
| US2008/0183128(A1) | 2008-07-01 | Morriss et al. | Applicant |
| US2008/0195041(A1) | 2008-08-01 | Goldfarb et al. | Applicant |
| US2008/0228085(A1) | 2008-09-01 | Jenkins et al. | Applicant |
| US2008/0234720(A1) | 2008-09-01 | Chang et al. | Applicant |
| US2008/0243140(A1) | 2008-10-01 | Gopferich et al. | Applicant |
| US2008/0262468(A1) | 2008-10-01 | Clifford et al. | Applicant |
| US2008/0262505(A1) | 2008-10-01 | Shahoian | Applicant |
| US2008/0262508(A1) | 2008-10-01 | Clifford et al. | Applicant |
| US2008/0262509(A1) | 2008-10-01 | Clifford et al. | Applicant |
| US2008/0262510(A1) | 2008-10-01 | Clifford | Applicant |
| US2008/0275483(A1) | 2008-11-01 | Makower et al. | Applicant |
| US2008/0281156(A1) | 2008-11-01 | Makower et al. | Applicant |
| US2008/0287908(A1) | 2008-11-01 | Muni et al. | Applicant |
| US2008/0306579(A1) | 2008-12-01 | Dolan et al. | Applicant |
| US2008/0319424(A1) | 2008-12-01 | Muni et al. | Applicant |
| US2009/0004272(A1) | 2009-01-01 | Gibson et al. | Applicant |
| US2009/0004273(A1) | 2009-01-01 | Gibson et al. | Applicant |
| US2009/0005763(A1) | 2009-01-01 | Makower et al. | Applicant |
| US2009/0017090(A1) | 2009-01-01 | Arensdorf et al. | Applicant |
| US2009/0028923(A1) | 2009-01-01 | Muni et al. | Applicant |
| US2009/0030274(A1) | 2009-01-01 | Goldfarb et al. | Applicant |
| US2009/0035351(A1) | 2009-02-01 | Berglund et al. | Applicant |
| US2009/0036968(A1) | 2009-02-01 | Hepworth et al. | Applicant |
| US2009/0036974(A1) | 2009-02-01 | Penn et al. | Applicant |
| US2009/0041824(A1) | 2009-02-01 | Zugates et al. | Applicant |
| US2009/0047326(A1) | 2009-02-01 | Eaton et al. | Applicant |
| US2009/0047327(A1) | 2009-02-01 | Eaton et al. | Applicant |
| US2009/0093823(A1) | 2009-04-01 | Chang et al. | Applicant |
| US2009/0156980(A1) | 2009-06-01 | Eaton et al. | Applicant |
| US2009/0177272(A1) | 2009-07-01 | Abbate et al. | Applicant |
| US2009/0187098(A1) | 2009-07-01 | Makower et al. | Applicant |
| US2009/0192488(A1) | 2009-07-01 | Eaton et al. | Applicant |
| US2009/0192489(A1) | 2009-07-01 | Eaton et al. | Applicant |
| US2009/0192490(A1) | 2009-07-01 | Eaton et al. | Applicant |
| US2009/0192491(A1) | 2009-07-01 | Eaton et al. | Applicant |
| US2009/0192492(A1) | 2009-07-01 | Eaton et al. | Applicant |
| US2009/0198179(A1) | 2009-08-01 | Abbate et al. | Applicant |
| US2009/0198216(A1) | 2009-08-01 | Muni et al. | Applicant |
| US2009/0220571(A1) | 2009-09-01 | Eaton et al. | Applicant |
| US2009/0227945(A1) | 2009-09-01 | Eaton et al. | Applicant |
| US2009/0238859(A1) | 2009-09-01 | Eaton et al. | Applicant |
| US2009/0240112(A1) | 2009-09-01 | Goldfarb et al. | Applicant |
| US2009/0306624(A1) | 2009-12-01 | Arensdorf et al. | Applicant |
| US2009/0312745(A1) | 2009-12-01 | Goldfarb et al. | Applicant |
| US2010/0043197(A1) | 2010-02-01 | Abbate et al. | Applicant |
| US2011/0004192(A1) | 2011-01-01 | Eaton et al. | Applicant |
| US2011/0004193(A1) | 2011-01-01 | Eaton et al. | Applicant |
| US2011/0004194(A1) | 2011-01-01 | Eaton et al. | Applicant |
| US2011/0004195(A1) | 2011-01-01 | Eaton et al. | Applicant |
| US2011/0004196(A1) | 2011-01-01 | Eaton et al. | Applicant |
| DE10105592(A1) | 2002-08-01 | Applicant | |
| JP2-500521(A) | 1990-02-01 | Applicant | |
| JP6-506672(A) | 1994-07-01 | Applicant | |
| JP2000-507630(A) | 2000-06-01 | Applicant | |
| JP2001-506144(A) | 2001-05-01 | Applicant | |
| JP2001-520188(A) | 2001-10-01 | Applicant | |
| WO-89/00839(A1) | 1989-02-01 | Applicant | |
| WO-97/36949(A1) | 1997-10-01 | Applicant | |
| WO-99/20261(A2) | 1999-04-01 | Applicant | |
| WO-99/20261(A3) | 1999-04-01 | Applicant | |
| WO-01/02024(A1) | 2001-01-01 | Applicant | |
| WO-01/02024(C1) | 2001-01-01 | Applicant | |
| WO-01/26658(A2) | 2001-04-01 | Applicant | |
| WO-01/26658(A3) | 2001-04-01 | Applicant | |
| WO3099359 | 2003-12-01 | Examiner | |
| WO-2004/082525(A2) | 2004-09-01 | Applicant | |
| WO-2004-082525(A3) | 2004-09-01 | Applicant | |
| WO-2006/020180(A2) | 2006-02-01 | Applicant | |
| WO-2006/020180(A3) | 2006-02-01 | Applicant | |
| WO-2006/107957(A2) | 2006-10-01 | Applicant | |
| WO-2006/107957(A3) | 2006-10-01 | Applicant | |
| WO-2007/067451(A2) | 2007-06-01 | Applicant | |
| WO-2007/067451(A3) | 2007-06-01 | Applicant | |
| WO-2007/134215(A2) | 2007-11-01 | Applicant | |
| WO-2007/134215(A3) | 2007-11-01 | Applicant | |
| WO-2008/008389(A2) | 2008-01-01 | Applicant | |
| WO-2008/008389(A3) | 2008-01-01 | Applicant | |
| WO-2008/033533(A2) | 2008-03-01 | Applicant | |
| WO-2008/051453(A2) | 2008-05-01 | Applicant | |
| WO-2008/051453(A3) | 2008-05-01 | Applicant | |
| WO-2008/051881(A2) | 2008-05-01 | Applicant | |
| WO-2008/051881(A3) | 2008-05-01 | Applicant | |
| WO-2008/054655(A2) | 2008-05-01 | Applicant | |
| WO-2008/070996(A1) | 2008-06-01 | Applicant | |
| WO-2009/079418(A2) | 2009-06-01 | Applicant | |
| WO-2009/079418(A3) | 2009-06-01 | Applicant | |
| WO-2010/014834(A1) | 2010-02-01 | Applicant |
Non-Patent Literature (60)
- Lapchenko, A.S. et al. (Jun. 1996). “Polyphosphazene Prosthesis of the Frontonasal Bypass in Surgical Treatment of Acute and Chronic Inflammation of the Frontal Sinuses,” Vestnik Otorinolarinologii, two pages.Applicant
- Lavigne, F. et al. (May 2002). “Intrasinus Administration of Topical Budesonide to Allergic Patients With Chronic Rhinosinusitis Following Surgery,” The Laryngoscope 112, seven pages.Applicant
- Piskunov, S.Z. et al. (May-Jun. 1989). “Application of Drugs Based on Polymers in the Treatment of Acute and Chronic Maxillary Sinusitis,” Vestnik Otorinolaringologii (3)33-35.Applicant
- Piskunov, S. at al. (1993). “The Prolongation of Drug Action in the Treatment of Diseases of the Nose and Paranasal Sinuses,” Rhinology 31:33-36.Applicant
- Shikani, A.H. (Aug. 1996). “Use of Antibiotics for Expansion of the Merocel® Packing Following Endoscopic Sinus Surgery,” ENT Journal 75(8):524-528.Applicant
- Thierry, B. et al. (Nov./Dec. 2003, e-pub. Oct. 7, 2003). “Bioactive Coatings of Endovascular Stents Based on Polyelectrolyte Multilayers,” Biomacromolecules 4:1564-1571.Applicant
- Hosemann, W. et al. (2003). “Innovative Frontal Sinus Stent Acting as a Local Drug-Releasing System,” Eur. Arch. Otorhinolarynology 260: 131-134.Applicant
- International Search Report mailed on Nov. 9, 2006, for PCT Patent Application No. PCT/US2006/012484 filed on Apr. 4, 2006, seven pages.Applicant
- Min, Y-G. et al. (1995). “Application of Polyactic Acid Polymer in the Treatment of Acute Maxillary Sinusitis in Rabbits,” Acta Otolaryngoogical 115:548-552.Applicant
- Min, Y-G et al. (Aug. 1995). “Mucociliary Activity and Histopathology of Sinus Mucosa in Experimental Mucosa in Experimental Maxillary Sinusitis: A Comparison of Systemic Administration of Antibiotic and Antibiotic Delivery by Polylactic Acid Polymer,” The Laryngoscope 105(8, Pt.1):835-842.Applicant
- Roumestan, C. et al. (2003). “Fluticasone Propionate and Mometasone Furoate Have Equivalent Transcriptional Potencies,” Clinical and Experimental Allergy 33: 895-901.Applicant
- Final Office Action mailed on Jan. 8, 2009 for U.S. Appl. No. 10/800,162, filed Mar. 12, 2004, 5 pages.Applicant
- Non-Final Office Action mailed on Jun. 6, 2008, for U.S. Appl. No. 10/800,162, filed Mar. 12, 2004, 5 pages.Applicant
- U.S. Appl. No. 12/258,277, filed Oct. 24, 2008, by Eaton et al.Applicant
- U.S. Appl. No. 12/258,282, filed Oct. 24, 2008, by Eaton et al.Applicant
- U.S. Appl. No. 12/270,695, filed Nov. 13, 2008, by Eaton et al.Applicant
- U.S. Appl. No. 12/334,373, filed Dec. 12, 2008, by Eaton et al.Applicant
- U.S. Appl. No. 12/334,382, filed on Dec. 12, 2008, by Abbate et al.Applicant
- U.S. Appl. No. 12/334,395, filed Dec. 12, 2008, by Abbate et al.Applicant
- Hietala, E-M. et al. (2001). “Biodegradation of the Copolymeric Polylactide Stent,” Journal of Vascular Research 38:361-369.Applicant
- Laaksovirta, S. (Aug. 22, 2003). Biodegradable, Self-Reinforced, Self-Expandable Lactic and Glycolic Acid (SR-PLGA 80/20) Copolymer Spiral Prostatic Stent: Analysis of Mechanical and Biological Properties and Clinical Results, Academic Dissertation, Medical School of the University of Tampere, 79 pages.Applicant
- Murphy, J.G. et al. (1992). “Percutaneous Polymeric Stents in Porcine Coronary Arteries: Initial Experience With Polyethylene Terephthalate Stents,” Circulation 86:1596-1604.Applicant
- Non-Final Office Action mailed on Sep. 22, 2009, for U.S. Appl. No. 12/419,927, filed Apr. 7, 2009, 4 pages.Applicant
- Non-Final Office Action mailed on Sep. 22, 2009, for U.S. Appl. No. 12/419,943, filed Apr. 7, 2009, 5 pages.Applicant
- Non-Final Office Action mailed on Sep. 22, 2009, for U.S. Appl. No. 12/419,930, filed Apr. 7, 2007, 4 pages.Applicant
- Non-Final Office Action mailed on Sep. 22, 2009, for U.S. Appl. No. 12/419,937, filed Apr. 7, 2009, 4 pages.Applicant
- Non-Final Office Action mailed on Sep. 22, 2009, for U.S. Appl. No. 12/419,925, filed Apr. 7, 2009, 4 pages.Applicant
- Non-Final Office Action mailed on Dec. 9, 2009, for U.S. Appl. No. 11/775,157, filed Jul. 9, 2007, 12 pages.Applicant
- Notice of Allowance mailed on Dec. 23, 2009, for U.S. Appl. No. 12/419,925, filed Apr. 7, 2009, 2 pages.Applicant
- Notice of Allowance mailed on Dec. 23, 2009, for U.S. Appl. No. 12/419,943, filed Apr. 7, 2009, 2 pages.Applicant
- Notice of Allowance mailed on Dec. 24, 2009, for U.S. Appl. No. 12/419,927, filed Apr. 7, 2009, 2 pages.Applicant
- Notice of Allowance mailed on Jan. 19, 2010, for U.S. Appl. No. 12/419,930, filed Apr. 7, 2009, 2 pages.Applicant
- Notice of Allowance mailed on Feb. 2, 2010, for U.S. Appl. No. 12/419,937, filed Apr. 7, 2009, 2 pages.Applicant
- Nuutinen, J-P. et al. (2002). “Mechanical Properties and in vitro Degradation of Bioresorbable Knitted Stents,” J. Biomater Sci. Polymer Edn. 13(12):1313-1323.Applicant
- Nuutinen, J-P. et al. (2003). “Theoretical and Experimental Evaluation of the Radial Force of Self-Expanding Braided Bioabsorbable Stents,” J. Biomater. Sci. Polymer Edn. 14(7):677-687.Applicant
- Parviainen, M. et al. (2000). “A New Biodegradable Stent for the Pancreaticojejunal Anastomosis After Pacreaticoduodenal Resection: In Vitro Examination and Pilot Experiences in Humans,” Pancreas 21(1):14-21.Applicant
- Su, S-H. et al. (2003). “Expandable Bioresorbable Endovascular Stent. I. Fabrication and Properties,” Annals of Biomedical Engineering 31:667-677.Applicant
- Tamai, H. et al. (1999). “A Biodegradable Ploy-/-lactic Acid Coronary Stent in the Porcine Coronary Artery,” Journal of Interventional Cardiology 12(6):443-450.Applicant
- Toffel. P.H. (Mar. 2001). “The Balanced Philosophy of Secure Mutltimodal Endoscopic Sinus Surgery and Adjunct Sue of Middle Meatal Stenting and Middle Turbinate Modification, Operative Techniques in Otolaryngology,” Head and Neck Surgery 12(1):40-45.Applicant
- Vogt. F. et al. (2004). “Long-Term Assessment of a Novel Biodegradable Paclitaxel-Eluting Coronary Polylactide Stent,” European Heart Journal 25:330-1340.Applicant
- Final Office Action mailed on Aug. 18, 2010, for U.S. Appl. No. 11/775,157, filed Jul. 9, 2007, 12 pages.Applicant
- Non-Final Office Action mailed on Jul. 1, 2010, for U.S. Appl. No. 12/479,794, filed Jun. 6, 2009, 5 pages.Applicant
- Nguyen, K.T. et al. (2004). “Biomaterials and Stent Technology,” Chapter 5 in Tissue Engineering and Novel Delivery Systems, 24 pages.Applicant
- European Search Report mailed on Feb. 21, 2011, for EP Patent Application No. 10011116.0 filed on Apr. 4, 2006, 9 pages.Applicant
- European Search Report mailed on Feb. 21, 2011, for EP Patent Application No. 10011117.8 filed on Apr. 4, 2006, 9 pages.Applicant
- European Search Report mailed on Feb. 21, 2011, for EP Patent Application No. 10011118.6 filed on Apr. 4, 2006, 9 pages.Applicant
- Final Office Action mailed on Jan. 27, 2011, for U.S. Appl. No. 12/479,794, filed Jun. 6, 2009, 6 pages.Applicant
- Non-Final Office Action mailed on Sep. 10, 2010, for U.S. Appl. No. 12/437,374, filed May 7, 2009, 8 pages.Applicant
- Non-Final Office Action mailed on Nov. 23, 2010, for U.S. Appl. No. 12/258,277, filed Oct. 24, 2008, 9 pages.Applicant
- Non-Final Office Action mailed on Nov. 23, 2010, for U.S. Appl. No. 12/258,282, filed Oct. 24, 2008, 7 pages.Applicant
- Non-Final Office Action mailed on Nov. 24, 2010, for U.S. Appl. No. 12/883,090, filed Sep. 15, 2010, 7 pages.Applicant
- Non-Final Office Action mailed on Nov. 24, 2010, for U.S. Appl. No. 12/883,056, filed Sep. 15, 2010, 7 pages.Applicant
- Non-Final Office Action mailed on Nov. 24, 2010, for U.S. Appl. No. 12/883,079, filed Sep. 15, 2010, 8 pages.Applicant
- Non-Final Office Action mailed on Mar. 22, 2011, for U.S. Appl. No. 12/883,071, filed Sep. 15, 2010, 8 pages.Applicant
- Notice of Allowance mailed on Mar. 18, 2011, for U.S. Appl. No. 12/258,277, filed Oct. 24, 2008, 7 pages.Applicant
- Notice of Allowance mailed on Mar. 21, 2011, for U.S. Appl. No. 12/258,282, filed Oct. 24, 2008, 8 pages.Applicant
- Notice of Allowance mailed on Mar. 21, 2011, for U.S. Appl. No. 12/883,059, filed Sep. 15, 2010, 10 pages.Applicant
- Notice of Allowance mailed on Mar. 23, 2011, for U.S. Appl. No. 12/883,079, filed Sep. 15, 2010, 9 pages.Applicant
- Notice of Allowance mailed on Mar. 25, 2011 for U.S. Appl. No. 12/883,090, filed Sep. 15, 2010, 8 pages.Applicant
- Notice of Allowance mailed on Mar. 25, 2011, for U.S. Appl. No. 12/883,056, filed Sep. 15, 2010, 8 pages.Applicant