Method to increase the bioavailability of cysteine

Patent Citations (3)

Non-Patent Literature (92)

• Yao et al., Protective effect of glucose-cysteine adduct on in situ perfused liver; Amino Acids 12:33, (1997).Applicant
• Droge, Oxidative Stress and Aging; Advances in Experimental and Medical Biology 543:191, Kluwer Academic/Plenum Publishers, New York, 2003.Applicant
• Droge et al., Modulation of Lymphocyte Functions and Immune Response by Cysteine and Cysteine Derivatives; The American Journal of Medicine 91:3C-140S, (1991).Applicant
• Buono et al., Total Sulfur Amino Acid Requirement in Young Men as Determined by Indicator Amino Acid Oxidation; American Journal of Clinical Nutrition 74:756, (2001).Applicant
• Cantin et al., Albumin-mediated Regulation of Cellular Glutathione and Nuclear Factor Kappa B Activation; American Journal of Respiratory and Critical Care Medicine 162:1539, (2001).Applicant
• Taurine; Alternative Medicine Review 6:78, (2001).Applicant
• Mansoor et al., Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma; Analytical Biochemistry 200:218, (1992).Applicant
• Post et al., “The effect of aging on constitutive mRNA levels . . . ” in “Physiological Senescence and its Postponement”, The New York Academy of Sciences, New York 1991.Applicant
• Rahbar, “The discovery of glycated hemoglobin” in “The Maillard Reaction”, The New York Academy of Sciences, New York, 2005.Applicant
• Szwergold et al., “Transglycation—a potential new mechanism for deglycation of Schiff's bases” in “The Maillard Reaction”, The New York Academy of Sciences, New York, 2005.Applicant
• Khan et al., Magnitude of Arsenic Toxicity in Tube-well Drinking Water in Bangladesh and Its Adverse Effects on Human Health . . . ; Asian Pacific Journal of Cancer Prevention 4:7, (2003).Applicant
• Greipp, Hyperpigmentation Syndromes (Diffuse Hypermelanosis); Archives of Internal Medicine 138:356, (1978).Applicant
• Meister et al., Glutathione; Annual Review of Biochemistry 52:711, (1988).Applicant
• Droge, The Plasma Redox State and Ageing; Ageing Research Reviews 1:257, (2002).Applicant
• Chen et al., Atherogenicity and Carcinogenicity of High-Arsenic Artesian Well Water; Arterisclerosis 8:452, (1998).Applicant
• Ochi, Arsenic compound-induced increases in glutathione levels in cultured Chinese hamster V79 cells and mechanisms associated with changes . . . ; Archives of Toxicology 71:730, (1997).Applicant
• Hayakawa et al; A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19; Archives of Toxicology 79:183, (2005).Applicant
• Bremer et al., Enzymic Methylation of Foreign Sulfhydryl Compounds; Biochimica et Biophysica Acta 46:217, (1961).Applicant
• Piscioto et al., Induction of Mucosal Glutathione Synthesis by Arsenic; Biochemica et Biophysica Acta 628:241, (1980).Applicant
• Cotgreave et al., Recent Trends in Glutathione Biochemistry—Glutathione-Protein Interactions . . . ; Biochemical and Biophysical Research Communications 242:1, (1998).Applicant
• Wills, Enzyme Inhibition by Allicin, the Active Principle of Garlic; Biochemical Journal 63:514, (1956).Applicant
• Crawhall et al., The intracellular Ratio of Cysteine to Cystine in Various Tissues; Biochemical Journal 105:891, (1967).Applicant
• Hack et al., The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention; Blood 92:59, (1998).Applicant
• Dai et al., Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System; Blood 93:268, (1999).Applicant
• Sondet et al., Mitochondria-targeting drugs arsenic trioxide and Ionidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis; Blood 97:3931, (2001).Applicant
• Grad et al., Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells; Blood 98:805, (2001).Applicant
• Gyamlani et al., Acetaminophen toxicity: suicidal vs accidental; BioMed. Central Critical Care 6:155, (2002).Applicant
• Chasseaud, Reaction with electrophiles after enzyme-catalysed deacetylation of N-acetylcysteine; Biochemical Pharmacology 23:1133, (1974).Applicant
• Das et al., Nitric Oxide Synthase is a Unique Mechanism of Garlic Action; Biochemical Society Transactions 23:S136, (1995).Applicant
• Smith et al., Contamination of drinking-water by arsenic in Bangladesh: a public health emergency; Bulletin of the World Health Organization 78:1093, (2000).Applicant
• Neuhouser et al., Fruits and Vegetables Are Associated with Lower Lung Cancer Risk Only in the Placebo Arm . . . ; Cancer Epidemiology, Biomarkers & Prevention 12:350, (2003).Applicant
• Birwe et al., High-performance liquid chromatographic determination of urinary cysteine and cystine; Clinica Chimica Acta 67:417, (1991).Applicant
• Mortensen et al., Glucosylation of human haemoglobin A. Dynamic variation in HbA1c described by a biokinetic model; Clinica Chimica Acta 136:75, (1984).Applicant
• Herrmann et al., Disturbed Homocysteine and Methionine Cycle Intermediates S-Adenosylhomocysteine and S-Adenosylmethionine Are Related . . . ; Clinical Chemistry 51:5, (2005).Applicant
• Hu et al., Arsenic trioxide induces apoptosis in cells of MOLT-4 and its daunorubicin-resistant cell line via depletion of . . . ; Cancer Chemotherapy and Pharmacology 52:47, ( 2003).Applicant
• Bahlis et al., Feasibility and Correltaes of Arsenic Trioxide Combined with Ascorbic Acid-mediated Depletion of Intrecellular Glutathone . . . ; Clinical Cancer Research 8:3658, (2002).Applicant
• Sparnins et al., Effects of organosulfur compounds from garlic and onions on benzo[a] pyrene-induced neoplasia and glutathione S-transferase activity . . . ; Carcinogenesis 9:131, (1988).Applicant
• Droge., Cysteine and glutathione in catabolic conditions and immunological dysfunction; Current Opinion in Clinical Nutrition and Metabolic Care 2:227, (1999).Applicant
• Shirin et al., Antiproliferative Effects of S-Allylmercaptocysteine on Colon Cancer Cells When Tested Alone or in Combination with Sulindac Sulfide; Cancer Research 61:725, (2001).Applicant
• Scott et al., Reactions of Arsenid (III) and Arsenic (V) Species with Glutathione; Chemical Research in Toxicology 6:102, (1993).Applicant
• Styblo et al., Comparative Inhibition of Yeast Glutathione Reductase by Arsenicals and Arsenothiols; Chemical Research in Toxicology 10:27, (1997).Applicant
• Droge., Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants; Experimental Gerontology 37:1331, (2002).Applicant
• Smith et al., Arseinc-Induced Skin Leaions among Atacameno People in Northern Chile Despite Good Nutrition and Centuries of Exposure; Environmental Health Perspectives 108:617, (2000).Applicant
• Mitra, et al., Nutritional Factors and Susceptibility to Arsenic Caused Skin Lesions in West Bengal, India; Environmental Health Perspectives 112:1104, (2001).Applicant
• Jocelyn, The Standard Redox Potential of Cysteine-Cystine from the Thiol-Disulfide Exchange Reaction with Glutathione and Lipolic Acid; European Journal of Biochemistry 2:327, (1967).Applicant
• De Rosa et al., N-acetylcysteine replenishes glutathione in HIV infection; European Journal of Clinical Investigation 30:915, (2000).Applicant
• Beaver et al., A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes; European Journal of Cell Biology 68:47, (1995).Applicant
• Das et al., Modification of Clastogenicity of Three Known Clastogens by Garlic Extract in Mice in Vivo; Environmental and Molecular Mutagenesis 21:383, (1993).Applicant
• Maiti et al., Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure . . . ; Environmental Toxicology and Pharmacology 8:227 (2000).Applicant
• Kawakami et al., Identification and characterization of oxidized human serum albumin; FEBS Journal 273:3346, (2006).Applicant
• Mendiratta et al., Erythrocyte Ascorbate Recycling: Antioxidant Effects in Blood; Free Radicals in Biology and Medicine 24:789, (1998).Applicant
• Shannon et al., Arsenic-induced Skin Toxicity; Human Toxicology 8:99, (1989).Applicant
• Mazumder et al., Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India; International Journal of Epidemiology 27:871, (1998).Applicant
• Lawsonet al., Allicin and Allicin-Derived Garlic Compounds Increase Breath Acetone through Allyl Methyl Sulfide . . . ; Journal of Agricultural and Food Chemistry 53:1974, (2005).Applicant
• Zhang et al., Structural Requirements for the Binding of Modified Proteins to the Scavenger Receptor of Macrophages; The Journal of Biological Chemistry 268:5535, (1993).Applicant
• Kala et al., The MRP2/cMOAT Transporter and Arsenic-Glutathione Complex Formation Are Required for Biliary Excretion of Arsenic; The Journal of Biological Chemistry 275:33404, (2000).Applicant
• Bald et al., Analysis of plasma thiols by high-performance liquid chromatography with ultraviolet detection; Journal of Chromatography A 1032:109, (2004).Applicant
• Yang et al., Effect of ageing on human plasma glutathione concentrations as determined by high-performance liquid . . . ; Journal of Chromatography B Biomedical Applications 674:2 (1995).Applicant
• Orringer et al., An Ascorbate-Mediated Transmembrane-Reducing System of the Human Erythrocyte; Journal of Clinical Investigation 63:53, (1979).Applicant
• Ishii et al., Regulation of Glutathione Levels in Mouse Spleen Lymphocytes by Transport of Cysteine; Journal of Cellular Physiology 133:330, (1987).Applicant
• Mazumder, Chronic Arsenic Toxicity: Clinical Features, Epidemiology, and Treatment: Experience in West Bengal; Journal of Environmental Science and Health; A38:141, (2003).Applicant
• Wierzbicka et al., Glutathione in Food; Journal of Food Composition and Analysis 2:327, (1989).Applicant
• Villa et al., Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense; Journal of Infectious Diseases 185:1115, (2002).Applicant
• Barnhart et al., Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro . . . ; Journal of Lipid Research 30:1703, (1989).Applicant
• Breitkreutz et al., Improvement of immune functions in HIV infection by sulfur supplementation: two randomized trials; Journal of Molecular Medicine 78:55, (2000.Applicant
• Freidman et al., Nutritional Improvement of Soy Flour; Journal of Nutrition 114:2241, (1984).Applicant
• Lau, Suppression of LDL Oxidation by Garlic; Journal of Nutrition 131, supplement 3S:985S, (2001).Applicant
• Mariotti et al., Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship . . . ; Journal of Nutrition 134:128, (2004).Applicant
• Blair et al., Oral L-2-Oxo-4-thiazolidine Reduces Bacterial Translocation after Radiation in the Fischer Rat; Journal of Surgical Research 65:165, (1996).Applicant
• Hildebrandt et al., Plasma cystine concentration and redox state in aging and physical exercise; Mechanisms of Ageing and Development 123:1269, (2002).Applicant
• Szwergold., alpha-Thiolamines such as cysteine and cysteamine act as effective transglycating agents due to formation of irreversible . . . ; Medical Hypotheses 66:698, (2006).Applicant
• Liu et al., Overexpression of Glutathione S-Transferase II and Multidrug Resistance Transport Proteins Is Associated with Acquired Tolerance . . . ; Molecular Pharmacology 60:302, (2001).Applicant
• Hamm et al., Changes in the Sulphydryl and Disulfide Groups in Beef Muscle Proteins During Heating; Nature 207:1269, (1965).Applicant
• O'Mullan et al., Sniffing Out the Truth; The New York Times, Jan. 21, 2007.Applicant
• Turin; What You Can't Smell Will Kill You; The New York Times, Jan. 21, 2007.Applicant
• Nakagawa et al., Prevention of Liver Damage by Aged Garlic Extract and Its Components in Mice; Phytotherapy Research 3:50, (1989).Applicant
• Jung et al., Effect of Different Garlic Preparations on the Fluidity of Blood, Fibrolytic activity, and Peripheral Microcirculation in comparison with . . . ; Planta Medica 56:668, (1990).Applicant
• Lawson et al., Pre-Hepatic Fate of the Organosulfur Compounds Derived from Garlic (Allium sativum); Planta Medica 59:A688, (1993).Applicant
• Liu et al., Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity; Proceedings of the National Academy of Seicnce 98:1643, (2001).Applicant
• Droge, Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philosophical Transactions of the Royal Society 360:2355, (2005).Applicant
• Tateishi et al., “Regulation of Glutathione Level in . . . ” in “Glutathione Centennial: Molecular Perspectives and Clinical Implications”, Academic Press, New York, 1989.Applicant
• Bannai et al., “Regulation of Glutathione Level by . . . ” in “Glutathione Centennial: Molecular Perspectives and Clinical Implications”, Academic Press, New York, 1989.Applicant
• Barron et al., Enzyme Systems Containing Active Sulphydryl Groups. The Role of Glutathione; Science 97:356, (1943).Applicant
• Zakharyan et al., Arsenite Methylation by Methylvitamin B12 and Glutahtione Does Not Require an Enzyme; Toxicology and Applied Pharmacology 154:287, (1999).Applicant
• Brambila et al., Chronic Arsenic-Exposed Human Prostate Epithelial Cells Exhibit Stable Arsenic Tolerance . . . ; Toxicology and Applied Pharmacology 183:99, (2002).Applicant
• Chen et al., Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan; Toxicology and Applied Pharmacology 206:198, (2005).Applicant
• Vahter et al., Effects of Low Dietary Intake of Methionine, Choline or Proteins on the Biotransformation of Arsenite in the Rabbit; Toxicology Letters 37:41, (1987).Applicant
• White et al., Toxicity Evaluations of L-cysteine and Procysteine, a Cysteine Prodrug, Given Once Intravenously to Neonatal Rats; Toxicology Letters 69:15, (1993).Applicant
• Huang et al., Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells; Toxicology 79:195, (1993).Applicant
• Gomez et al. Attenuation of acetaminophen hepatotoxicity in mice as evidence for the bioavailability of the cysteine in D-glucose-L-cysteine in vivo; Toxicology Letters 70:101, (1994).Applicant
• Schuliga et al., Upregulation of Glutathione-Related Genes and Enzyme Activities in Cultured Human Cells by Sublethal Concentrations of . . . ; Toxicological Sciences 70:183, (2002).Applicant
• Kojima et al., Chronic Exposure to Methylated Arsenicals Stimulates Arsenic Excretion Pathways and Induces Arsenic Tolerance in Rat Liver Cells; Toxicological Sciences 91:70, (2006).Applicant