US 7,599,736 B2Grant

Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease

Issue Date:2009-10-06

•478 Claims

•19 Drawing Sheets

Abstract

A method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. The method and apparatus includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, the method and apparatus includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulates sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

Metadata

Assignee

DiLorenzo Biomedical, LLC

Inventor

Daniel John DiLorenzo

Application Information

Application Number:US 10/198,871

Filing Date:2002-07-19

Priority Date:2001-07-23

Art Unit:3766

Classifications

IPC:

A61N1/18

Patent Drawings (19 sheets)

Description

Cross Reference to Related Applications

[0001] This application claims the benefit of copending U.S. Provisional Patent Application No. 60/307,124 entitled “Physiologic modulation for the control of obesity, depression, epilepsy, and diabetes”, filed Jul. 23, 2001 and naming as inventor Daniel John DiLorenzo.

Background of Invention

[0002] 1. Field of the Invention

[0003] The present invention relates generally to metabolic disease and neuropsychiatric disease and, more particularly, to stimulation of gastric and sympathetic neural tissue for the treatment of obesity and depression.

[0004] 2. Related Art

[0005] Physiologic studies have demonstrated the presence of a sympathetic nervous system afferent pathway transmitting gastric distention information to the hypothalamus. [Barone, Zarco de Coronado et al. (1995). Gastric distension modulates hypothalamic neurons via a sympathetic afferent path through the mesencephalic periaqueductal gray. Brain Research Bulletin. 38: 239-51.] However, prior techniques have generally not addressed the problems associated with satiety, morbidity, mortality of intracranial modulation and the risk of ulcers. Unlike prior techniques, by specifically targeting sympathetic afferent fibers, the present invention effects the sensation of satiety and avoids the substantial risks of morbidity and mortality of intracranial modulation, particularly dangerous in the vicinity of the hypothalamus. Furthermore, this invention avoids the risk of ulcers inherent in vagus nerve stimulation.

[0006] A. Satiety. Stimulation of intracranial structures has been proposed and described for the treatment of obesity (U.S. Pat. No. 5,782,798). Stimulation of the left ventromedial hypothalamic (VMH) nucleus resulted in delayed eating by dogs who had been food deprived. Following 24 hours of food deprivation, dogs with VMH stimulation waited between 1 and 18 hours after food presentation before consuming a meal. Sham control dogs ate immediately upon food presentation. Dogs that received 1 hour of stimulation every 12 hours for 3 consecutive days maintained an average daily food intake of 35% of normal baseline levels. [Brown, Fessler et al. (1984). Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs. Journal of Neurosurgery. 60: 1253-7.] B. Candidate Peripheral Nerve Pathways for Modulating Satiety. B1. Sympathetic Afferents The effect of gastric distension on activity in the lateral hypothalamus-lateral preoptic area-medial forebrain bundle (LPA-LH-MFB) was studied to determine the pathways for this gastric afferent input to the hypothalamus. [Barone, Zarco de Coronado et al. (1995). Gastric distension modulates hypothalamic neurons via a sympathetic afferent path through the mesencephalic periaqueductal gray. Brain Research Bulletin. 38: 239-51.] The periaqueductal gray matter (PAG) was found to be a relay station for this information. This modulation of the hypothalamus was attenuated but not permanently eliminated by bilateral transection of the vagus nerve. This modulation was, however, significantly reduced or eliminated by bilateral transection of the cervical sympathetic chain or spinal transection at the first cervical level. These signals containing gastric distension and temperature stimulation are mediated to a large degree by sympathetic afferents, and the PAG is a relay station for this gastric afferent input to the hypothalamus. For example, in the LPA-LH-MFB study, 26.1% of the 245 neurons studied were affected by gastric stimulation, with 17.6% increasing in firing frequency and 8.6% decreasing during gastric distension. [Barone, Zarco de Coronado et al. (1995). Gastric distension modulates hypothalamic neurons via a sympathetic afferent path through the mesencephalic periaqueductal gray. Brain Research Bulletin. 38: 239-51.] The response of 8 of 8 neurons sensitive to gastric distension were maintained, though attenuated after bilateral vagus nerves were cut. In 2 of these 8 cells, the effect was transiently eliminated for 2-4 minutes after left vagus transection, and then activity recovered. In 3 LH-MFB cells, two increased and the other decreased firing rate with gastric distension. Following bilateral sympathetic ganglion transection, the response of two were eliminated, and the third (which increased firing with distension) had a significantly attenuated response. [Barone, Zarco de Coronado et al. (1995). Gastric distension modulates hypothalamic neurons via a sympathetic afferent path through the mesencephalic periaqueductal gray. Brain Research Bulletin. 38: 239-51.] Vagus stimulation resulted in opposite or similar responses as gastric distension on the mesencephalic cells. B2. Vagus Nerve Afferents. Gastric vagal input to neurons throughout the hypothalamus has been characterized. [Yuan and Barber (1992). Hypothalamic unitary responses to gastric vagal input from the proximal stomach. American Journal of Physiology. 262: G74-80.] Nonselective epineural vagus nerve stimulation (VNS) has been described for the treatment of Obesity (U.S. Pat. No. 5,188,104). This suffers from several significant limitations that are overcome by the present invention.

[0007] The vagus nerve is well known to mediate gastric hydrochloric acid secretion. Dissection of the vagus nerve off the stomach is often performed as part of major gastric surgery for ulcers. Stimulation of the vagus nerve may pose risks for ulcers in patients, of particular concern, as obese patients often have gastroesophageal reflux disease (GERD); further augmentation of gastric acid secretion would only exacerbate this condition.

[0008] C. Assessment of Sympathetic and Vagus Stimulation. The present invention teaches a significantly more advanced neuroelectric interface technology to stimulate the vagus nerve and avoid the efferent vagus side effects, including speech and cardiac side effects common in with existing VNS technology as well as the potential ulcerogenic side effects. However, since sympathetic afferent activity appears more responsive to gastric distension, this may represent a stronger channel for modulating satiety. Furthermore, by pacing stimulating modulators on the greater curvature of the stomach, one may stimulate the majority of the circular layer of gastric musculature, thereby diffusely increasing gastric tone.

[0009] D. Neuromuscular Stimulation. The muscular layer of the stomach is comprised of 3 layers: (1) an outer longitudinal layer, (2) a circular layer in between, and (3) a deeper oblique layer. [Gray (1974). Gray's Anatomy. T. Pick and R. Howden. Philadelphia, Running Press.] The circular fibers, which lie deep to the superficial longitudinal fibers, would appear to be the layer of choice for creating uniform and consistent gastric contraction with elevated wall tension and luminal pressure. Therefore, modulators should have the ability to deliver stimulation through the longitudinal layer. If the modulator is in the form of an electrode, then the electrodes should have the ability to deliver current through the longitudinal layer.

[0010] Gray's Anatomy describes innervation as including the right and left pneumogastric nerves (not the vagus nerves), being distributed on the back and front of the stomach, respectively. A great number of branches from the sympathetic nervous system also supply the stomach. [Gray (1974). Gray's Anatomy. T. Pick and R. Howden. Philadelphia, Running Press.] Metabolic Modulation (Efferent) Electrical stimulation of the VMH enhances lipogenesis in the brown adipose tissue (BAT), preferentially over the white adipose tissue (WAT) and liver, probably through a mechanism involving activation of the sympathetic innervation of the BAT. [Takahashi and Shimazu (1982). Hypothalamic regulation of lipid metabolism in the rat: effect of hypothalamic stimulation on lipogenesis. Journal of the Autonomic Nervous System. 6: 225-35.] The VMH is a hypothalamic component of the sympathetic nervous system. [Ban (1975). Fiber connections in the hypothalamus and some autonomic functions. Pharmacology, Biochemistry & Behavior. 3: 3-13.] A thermogenic response in BAT was observed with direct sympathetic nerve stimulation. [Flaim, Horwitz et al. (1977). Coupling of signals to brown fat: a- and b-adrenergic responses in intact rats. Amer. J. Physiol. 232: R101-R109.] The BAT had abundant sympathetic innervation with adrenergic fibers that form nest-like networks around every fat cell, [Derry, Schonabum et al. (1969). Two sympathetic nerve supplies to brown adipose tissue of the rat. Canad. J. Physiol. Pharmacol. 47: 57-63.] whereas WAT has no adrenergic fibers in direct contact with fat cells except those related to the blood vessels. [Daniel and Derry (1969). Criteria for differentiation of brown and white fat in the rat. Canad. J. Physiol. Pharmacol. 47: 941-945.]

Summary of Invention

[0011] The present invention teaches apparatus and methods for treating a multiplicity of diseases, including obesity, depression, epilepsy, diabetes, and other diseases. The invention taught herein employs a variety of energy modalities to modulate central nervous system structures, peripheral nervous system structures, and peripheral tissues and to modulate physiology of neural structures and other organs, including gastrointestinal, adipose, pancreatic, and other tissues. The methods for performing this modulation, including the sites of stimulation and the modulator configurations are described. The apparatus for performing the stimulation are also described. This invention teaches a combination of novel anatomic approaches and apparatus designs for direct and indirect modulation of the autonomic nervous system, which is comprised of the sympathetic nervous system and the parasympathetic nervous system.

[0012] For the purposes of this description the term GastroPace should be interpreted to mean the devices constituting the system of the present embodiment of this invention.

[0013] A. Obesity and Eating Disorders. The present invention teaches several mechanisms, including neural modulation and direct contraction of the gastric musculature, to effect the perception of satiety. This modulation is useful in the treatment of obesity and eating disorders, including anorexia nervosa and bulemia.

[0014] Direct stimulation of the gastric musculature increases the intraluminal pressure within the stomach; and this simulates the physiologic condition of having a full stomach, sensed by stretch receptors in the muscle tissue and transmitted via neural afferent pathways to the hypothalamus and other central nervous system structures, where the neural activity is perceived as satiety.

[0015] This may be accomplished with the several alternative devices and methods taught in the present invention. Stimulation of any of the gastric fundus, greater curvature of stomach, pyloric antrum, or lesser curvature of stomach, or other region of the stomach or gastrointestinal tract, increases the intraluminal pressure. Increase of intraluminal pressure physiologically resembles fullness of the respective organ, and satiety is perceived.

[0016] The present invention also includes the restriction of the flow of food to effect satiety. This is accomplished by stimulation of the pylorus. The pylorus is the sphincter-like muscle at the distal juncture of the stomach with the duodenum, and it regulates food outflow from the stomach into the duodenum. By stimulating contraction of the pylorus, food outflow from the stomach is slowed or delayed. The presence of a volume of food in the stomach distends the gastric musculature and causes the person to experience satiety.

[0017] B. Depression and Anxiety. An association has been made between depression and overeating, particularly with the craving of carbohydrates; and is believed to be an association between the sense of satiety and relief of depression. Stimulation of the gastric tissues, in a manner that resembles or is perceived as satiety, as described above, provides relief from this craving and thereby relief from some depressive symptoms.

[0018] There are several mechanisms, including those taught above for the treatment of obesity that are applicable to the treatment of depression, anxiety, and other neuropsychiatric conditions. C. Epilepsy. The present invention includes electrical stimulation of peripheral nervous system and other structures and tissues to modulate the activity in the central nervous system to control seizure activity.

[0019] This modulation takes the form of peripheral nervous system stimulation using a multiplicity of novel techniques and apparatus. Direct stimulation of peripheral nerves is taught; this includes stimulation of the vagus, trigeminal, accessory, and sympathetic nerves. Indiscriminate stimulation of the vagus nerves has been described for some disorders, but the limitations in this technique are substantial, including cardiac rhythm disruptions, speech difficulties, and gastric and duodenal ulcers. The present invention overcomes these persistent limitations by teaching a method and apparatus for the selective stimulation of structures, including the vagus nerve as well as other peripheral nerves, and other neural, neuromuscular, and other tissues.

[0020] The present invention further includes noninvasive techniques for neural modulation. This includes the use of tactile stimulation to activate peripheral or cranial nerves. This noninvasive stimulation includes the use of tactile stimulation, including light touch, pressure, vibration, and other modalities that may be used to activate the peripheral or cranial nerves. Temperature stimulation, including hot and cold, as well as constant or variable temperatures, are included in the present invention.

[0021] D. Diabetes. The response of the gastrointestinal system, including the pancreas, to a meal includes several phases. The first phase, the anticipatory stage, is neurally mediated. Prior to the actual consumption of a meal, saliva production increases and the gastrointestinal system prepares for the digestion of the food to be ingested. Innervation of the pancreas, in an analogous manner, controls production of insulin.

[0022] Modulation of pancreatic production of insulin may be performed by modulation of at least one of afferent or efferent neural structures. Afferent modulation of at least one of the vagus nerve, the sympathetic structures innervating the gastrointestinal tissue, the sympathetic trunk, and the gastrointestinal tissues themselves is used as an input signal to influence central and peripheral nervous system control of insulin secretion.

Brief Description of Drawings

[0023] FIG. 1 depicts GastroPace implanted along the Superior Greater Curvature of the stomach for both Neural Afferent and Neuromuscular Modulation.

[0024] FIG. 2 depicts GastroPace implanted along the Inferior Greater Curvature of the stomach for both Neural Afferent and Neuromuscular Modulation.

[0025] FIG. 3 depicts GastroPace implanted along the Pyloric Antrum of the stomach for both Neural Afferent and Neuromuscular Modulation.

[0026] FIG. 4 depicts GastroPace implanted adjacent to the Gastric Pylorus for modulation of pylorus activity and consequent control of gastric food efflux and intraluminal pressure.

[0027] FIG. 5 depicts GastroPace implanted along the Pyloric Antrum of the stomach with modulators positioned for stimulation of Neural and Neuromuscular structures of the Pylorus and Pyloric Antrum of the Stomach.

[0028] FIG. 6 depicts GastroPace implanted along the Pyloric Antrum of the stomach with modulators positioned for stimulation of Neural and Neuromuscular structures of the Pylorus, Pyloric Antrum, Greater Curvature, and Lesser Curvature of the Stomach.

[0029] FIG. 7 depicts the Nerve Cuff Electrode, comprising the Epineural Electrode Nerve Cuff Design.

[0030] FIG. 8 depicts the Nerve Cuff Electrode, comprising the Axial Electrode Blind End Port Design.

[0031] FIG. 9 depicts the Nerve Cuff Electrode, comprising the Axial Electrode Regeneration Port Design.

[0032] FIG. 10 depicts the Nerve Cuff Electrode, comprising the Axial Regeneration Tube Design.

[0033] FIG. 11 depicts GastroPace implanted along the Pyloric Antrum of the stomach with modulators positioned for stimulation of Afferent Neural Structures, including sympathetic and parasympathetic fibers.

[0034] FIG. 12 depicts GastroPace implanted along the Pyloric Antrum of the stomach with modulators positioned for stimulation of Neural and Neuromuscular structures of the Pylorus, Pyloric Antrum, Greater Curvature, and Lesser Curvature of the Stomach and with modulators positioned for stimulation of Afferent Neural Structures, including sympathetic and parasympathetic fibers.

[0035] FIG. 13 depicts the Normal Thoracoabdominal anatomy as seen via a saggital view of an open dissection.

[0036] FIG. 14 depicts modulators for GastroPace positioned on the sympathetic trunk and on the greater and lesser splanchnic nerves, both supradiaphragmatically and infradiaphragmatically, for afferent and efferent neural modulation.

[0037] FIG. 15 depicts GastroPace configured with multiple pulse generators, their connecting cables, and multiple modulators positioned on the sympathetic trunk and on the greater and lesser splanchnic nerves, both supradiaphragmatically and infradiaphragmatically, for afferent and efferent neural modulation.

[0038] FIG. 16 depicts GastroPace configured with multiple pulse generators, their connecting cables, and multiple modulators positioned on the sympathetic trunk and on the greater and lesser splanchnic nerves, both supradiaphragmatically and infradiaphragmatically, for afferent and efferent neural modulation and with modulators positioned for stimulation of Neural and Neuromuscular structures of the Pylorus, Pyloric Antrum, Greater Curvature, and Lesser Curvature of the Stomach.

[0039] FIG. 17 depicts the Normal Spinal Cord Anatomy, shown in Transverse Section.

[0040] FIG. 18 depicts GastroPace implanted with multiple modulators positioned for modulation of Spinal Cord structures

Detailed Description

[0041] The present invention encompasses a multimodality technique, method, and apparatus for the treatment of several diseases, including but not limited to obesity, eating disorders, depression, epilepsy, and diabetes.

[0042] These modalities may be used for diagnostic and therapeutic uses, and these modalities include but are not limited to stimulation of gastric tissue, stimulation of gastric musculature, stimulation of gastric neural tissue, stimulation of sympathetic nervous tissue, stimulation of parasympathetic nervous tissue, stimulation of peripheral nervous tissue, stimulation of central nervous tissue, stimulation of cranial nervous tissue, stimulation of skin receptors, including Pacinian corpuscles, nociceptors, golgi tendons, and other sensory tissues in the skin, subcutaneous tissue, muscles, and joints.

[0043] Stimulation may be accomplished by electrical means, optical means, electromagnetic means, radiofrequency means, electrostatic means, magnetic means, vibrotactile means, pressure means, pharmacologic means, chemical means, electrolytic concentration means, thermal means, or other means for altering tissue activity.

[0044] Already encompassed in the above description are several specific applications of this broad technology. These specific applications include electrical stimulation of gastric tissue, including at least one of muscle and neural, for the control of appetite and satiety, and for the treatment of obesity. Additional specific uses include electrical stimulation of gastric tissue for the treatment of depression. Further uses include electrical stimulation of pancreatic tissue for the treatment of diabetes. A. Satiety Modulation. A1. Sympathetic Afferent Stimulation. Selected stimulation of the sympathetic nervous system is an objective of the present invention. A variety of modulator designs and configurations are included in the present invention and other designs and configurations may be apparent to those skilled in the art and these are also included in the present invention. Said modulator may take the form of electrode or electrical source, optical source, electromagnetic source, radiofrequency source, electrostatic source, magnetic source, vibrotactile source, pressure source, pharmacologic source, chemical source, electrolyte source, thermal source, or other energy or stimulus source.

[0045] One objective of the modulator design for selective sympathetic nervous system stimulation is the avoidance of stimulation of the vagus nerve. Stimulation of the vagus nerve poses the risk enhanced propensity for development of gastric or duodenal ulcers.

[0046] Other techniques in which electrical stimulation has been used for the treatment of obesity have included stimulation of central nervous system structures or peripheral nervous system structures. Other techniques have used sequential stimulation of the gastric tissue to interrupt peristalsis; however, this broad stimulation of gastric tissue necessarily overlaps regions heavily innervated by the vagus nerve and consequently poses the same risks of gastric and duodenal ulcers that stimulation of the vagus nerve does.

[0047] One objective of the present invention is the selective stimulation of said afferent neural fibers that innervate gastric tissue. Avoidance of vagus nerve stimulation is an object of this modulator configuration. Other alternative approaches to gastric pacing involving gastric muscle stimulation secondarily cause stimulation of the vagus nerve as well as stimulation of gastric tissues in acid-secreting regions, consequently posing the undesirable side effects of gastric and duodenal ulcers secondary to activation of gastric acid stimulation.

[0048] There are a number of approaches to selective stimulation of the sympathetic nervous system. This invention includes stimulation of the sympathetic fibers at sites including the zones of innervation of the stomach, the gastric innervation zones excluding those innervated by vagus branches, the distal sympathetic branches proximal to the stomach, the sympathetic trunk, the intermediolateral nucleus, the locus ceruleus, the hypothalamus, and other structures comprising or influencing sympathetic afferent activity.

[0049] Stimulation of the sympathetic afferent fibers elicits the perception of satiety, and achievement of chronic, safe, and efficacious modulation of sympathetic afferents is one of the major objectives of the present invention.

[0050] Alternating and augmenting stimulation of the sympathetic nervous system and vagus nerve is included in the present invention. By alternating stimulation of the vagus nerve and the sympathetic afferent fibers, one may induce the sensation of satiety in the implanted patient while minimizing the potential risk for gastric and duodenal ulcers.

[0051] Since vagus and sympathetic afferent fibers carry information that is related to gastric distention, a major objective of the present invention is the optimization stimulation of the biggest fibers, the afferent sympathetic nervous system fibers, and other afferent pathways such that a maximal sensation of satiety is perceived in the implanted individual and such that habituation of this sensation of satiety is minimized. This optimization is performed in any combination of matters including temporal patterning of the individual signals to each neural pathway, including but not limited to the vagus nerve and sympathetic afferents, as well as temporal patterning between a multiplicity of stimulation channels involving the same were neural pathways The present invention teaches a multiplicity of apparatus and method for stimulation of afferent sympathetic fibers, as detailed below. Other techniques and apparatus may become apparent to those skilled in the art, without departing from the present invention.

[0052] A1a. Sympathetic Afferents—Gastric Region. FIG. 1 through FIG. 3 demonstrate stimulation of gastric tissue, including at least one of neural and muscular tissue. Anatomical structures include esophagus 15, lower esophageal sphincter 14, stomach 8, cardiac notch of stomach 16, gastric fundus 9, greater curvature of stomach 10, pyloric antrum 11, lesser curvature of stomach 17, pylorus 12, and duodenum 13.

[0053] Implantable pulse generator 1 is shown with modulator 2 and modulator 3 in contact with the corresponding portion of stomach 8 in the respective figures, detailed below. Implantable pulse generator further comprises attachment fixture 4 and attachment fixture 5. Additional or fewer attachment fixtures may be included without departing from the present invention. Attachment means 6 and attachment means 7 are used to secure attachment fixture 4 and attachment fixture 5, respectively to appropriate portion of stomach 8. Attachment means 6 and attachment means 7 may be comprised from surgical suture material, surgical staples, adhesives, or other means without departing from the present invention.

[0054] FIGS. 1, 2, and 3 show implantable pulse generator 1 in several anatomical positions. In FIG. 1, implantable pulse generator 1 is shown positioned along the superior region of the greater curvature of stomach 10, with modulator 2 and modulator 3 in contact with the tissues comprising the greater curvature of stomach 10. In FIG. 2, implantable pulse generator 1 is shown positioned along the inferior region of the greater curvature of stomach 10, with modulator 2 and modulator 3 in contact with the tissues comprising the greater curvature of stomach 10. In FIG. 3, implantable pulse generator 1 is shown positioned along the pyloric antrum 11, with modulator 2 and modulator 3 in contact with the tissues comprising the pyloric antrum 11.

[0055] Modulator 2 and modulator 3 are used to stimulate at least one of gastric longitudinal muscle layer, gastric circular muscle layer, gastric nervous tissue, or other tissue. Modulator 2 and modulator 3 may be fabricated from nonpenetrating material or from penetrating material, including needle tips, arrays of needle tips, wires, conductive sutures, other conductive material, or other material, without departing from the present invention.

[0056] A1b. Sympathetic Afferents—Sympathetic Trunk. The present invention teaches apparatus and method for stimulation of sympathetic afferent fibers using stimulation in the region of the sympathetic trunk. As shown in FIGS. 14, 15, and 16, sympathetic trunk neuromodulatory interface 83 and 85, positioned on right sympathetic trunk 71, and sympathetic trunk neuromodulatory interface 85, 86 positioned on left sympathetic trunk 72, are used to provide stimulation for afferent as well as for efferent sympathetic nervous system modulation. Modulation of efferent sympathetic nervous system is discussed below, and this is used for metabolic modulation.

[0057] A1c. Sympathetic Afferents—Other. The present invention teaches apparatus and method for stimulation of sympathetic afferent fibers using stimulation of nerves arising from the sympathetic trunk. As shown in FIGS. 14, 15, and 16, thoracic splanchnic neuromodulatory interface 87, 89, 88, and 90, positioned on right greater splanchnic nerve 73, right lesser splanchnic nerve 75, left greater splanchnic nerve 74, left lesser splanchnic nerve 76, respectively, and are used to provide stimulation for afferent as well as for efferent sympathetic nervous system modulation. Modulation of efferent sympathetic nervous system is discussed below, and this is used for metabolic modulation.

[0058] A2. Gastric Musculature Stimulation. A further object of the present invention is the stimulation of the gastric musculature. This may be performed using either or both of closed loop and open loop control. In the present embodiment, a combination of open and closed loop control is employed. The open loop control provides a baseline level of gastric stimulation. This stimulation maintains tone of the gastric musculature. This increases the wall tension the stomach and plays a role in the perception of satiety in the implanted patient. Additionally, stimulation of the gastric musculature causes contraction of the structures, thereby reducing the volume of the stomach. This gastric muscle contraction, and the consequent reduction of stomach volume effectively restricts the amount of food that may be ingested. Surgical techniques have been developed and are known to those practicing in the field of surgical treatment of obesity. Several of these procedures are of the restrictive type, but because of their surgical nature they are fixed in magnitude and difficult if not impossible to reverse. The present invention teaches a technique which employs neural modulation and gastric muscle stimulation which by its nature is the variable and reversible. This offers the advantages postoperative adjustment of magnitude, fine tuning for the individual patient, varying of magnitude to suit the patient's changing needs and changing anatomy over time, and the potential for reversal or termination of treatment. Furthermore, since the gastric wall tension is generated in a physiological manner by the muscle itself, it does not have the substantial risk of gastric wall necrosis and rupture inherent in externally applied pressure, as is the case with gastric banding.

[0059] FIGS. 1, 2, and 3 depict placements of the implantable pulse generator 1 that may be used to stimulate gastric muscle tissue. Stimulation of both longitudinal and circular muscle layers is included in the present invention. Stimulation of gastric circular muscle layer causes circumferential contraction of the stomach, and stimulation of gastric longitudinal muscle layer causes longitudinal contraction of the stomach.

[0060] This muscle stimulation and contraction accomplishes several objectives: (1) functional reduction in stomach volume, (2) increase in stomach wall tension, (3) reduction in rate of food bolus flow. All of these effects are performed to induce the sensation of satiety.

[0061] A3. Gastric Pylorus Stimulation. FIG. 4 depicts implantable pulse generator 1 positioned to perform stimulation of the gastric pylorus 12 to induce satiety by restricting outflow of food bolus material from the stomach 8 into the duodenum 13. Stimulation of the pylorus 12 may be continuous, intermittent, or triggered manually or by sensed event or physiological condition. FIG. 4 depicts implantable pulse generator 1 positioned adjacent to the gastric pylorus 12; this position provides secure modulator positioning while eliminating the risk of modulator and wire breakage inherent in other designs in which implantable pulse generator 1 is positioned remote from the gastric pylorus 12.

[0062] FIG. 5 depicts implantable pulse generator 1 positioned to perform stimulation of the gastric pylorus 12 to induce satiety by restricting outflow of food bolus material from the stomach 8 into the duodenum 13. Stimulation of the pylorus 12 may be continuous, intermittent, or triggered manually or by sensed event or physiological condition. FIG. 5 depicts implantable pulse generator 1 attached to stomach 8, specifically by the pyloric antrum 11; this position facilitates the use of a larger implantable pulse generator 1. The risk of modulator and wire breakage is minimized by the use of appropriate strain relief and stranded wire designs.

[0063] A4. Parasympathetic Stimulation. The parasympathetic nervous system is complementary to the sympathetic nervous system and plays a substantial role in controlling digestion and cardiac activity. Several routes are described in the present invention to modulate activity of the parasympathetic nervous system.

[0064] A4a. Parasympathetic Stimulation—Vagus Nerve. Others have advocated the use of vagus nerve stimulation for the treatment of a number of disorders including obesity. Zabara and others have described systems in which the vagus nerve in the region of the neck is stimulated. This is plagued with a host of problems, including life-threatening cardiac complications as well as difficulties with speech and discomfort during stimulation. The present invention is a substantial advance over that discussed by Zabara et al, in which unrestricted fiber activation using epineural stimulation is described. That technique results in indiscriminate stimulation of efferent and afferent fibers. With vagus nerve stimulation, efferent fiber activation generates many undesirable side effects, including gastric and duodenal ulcers, cardiac disturbances, and others.

[0065] In the present invention, as depicted in FIG. 14, vagus neuromodulatory interface 97 and 98 are implanted adjacent to and in communication with right vagus nerve 95 and left vagus nerve 96. The neuromodulatory interface 97 and 98 overcomes these limitations that have persisted for over a decade with indiscriminate vagus nerve stimulation, by selectively stimulating afferent fibers of the at least one of the vagus nerve, the sympathetic nerves, and other nerves. The present invention includes the selective stimulation of afferent fibers using a technique in which electrical stimulation is used to block anterograde propagation of action potentials along the efferent fibers. The present invention includes the selective stimulation of afferent fibers using a technique in which stimulation is performed proximal to a nerve transection and in which the viability of the afferent fibers is maintained. One such implementation involves use of at least one of neuromodulatory interface 34 which is of the form shown in at least one of Longitudinal Electrode Neuromodulatory Interface 118, Longitudinal Electrode Regeneration Port Neuromodulatory Interface 119, Regeneration Tube Neuromodulatory Interface 120, or other design in which a subset of the neuronal polulaiton is modulated.

[0066] A.4.a.i. Innovative Stimulation Anatomy. FIG. 6 depicts multimodal treatment for the generation of satiety, using sympathetic stimulation, gastric muscle stimulation, gastric pylorus stimulation, and vagus nerve stimulation. This is described in more detail below. Modulators 30 and 31 are positioned in the general region of the lesser curvature of stomach 17. Stimulation in this region results in activation of vagus nerve afferent fibers. Stimulation of other regions may be performed without departing from the present invention. In this manner, selective afferent vagus nerve stimulation may be achieved, without the detrimental effects inherent in efferent vagus nerve stimulation, including cardiac rhythm disruption and induction of gastric ulcers.

[0067] A.4.a.ii. Innovative Stimulation Device. The present invention further includes devices designed specifically for the stimulation of afferent fibers.

[0068] FIG. 7 depicts epineural cuff electrode neuromodulatory interface 117, one of several designs for neuromodulatory interface 34 included in the present invention. Nerve 35 is shown inserted through nerve cuff 36. For selective afferent stimulation, the nerve 35 is transected distal to the epineural cuff electrode neuromodulatory interface 117. This case is depicted here, in which transected nerve end 37 is seen distal to epineural cuff electrode neuromodulatory interface 117. Epineural electrode—49, 50, and 51 are mounted along the inner surface of nerve cuff 36 and in contact or close proximity to nerve 35. Epineural electrode connecting wire 52, 53, 54 are electrically connected on one end to epineural electrode 49, 50, and 51, respectively, and merge together on the other end to form connecting cable 55.

[0069] FIG. 8 depicts longitudinal electrode neuromodulatory interface 118, one of several designs for neuromodulatory interface 34 included in the present invention. Nerve 35 is shown inserted into nerve cuff 36. For selective afferent stimulation, the nerve 35 is transected prior to surgical insertion into nerve cuff 36. Longitudinal electrode array 38 is mounted within nerve cuff 36 and in contact or close proximity to nerve 35. Connecting wire array 40 provides electrical connection from each element of longitudinal electrode array 38 to connecting cable 55. Nerve cuff end plate 41 is attached to the distal end of nerve cuff 36. Nerve 35 may be advanced sufficiently far into longitudinal electrode array 38 such that elements of longitudinal electrode array—38 penetrate into nerve 35. Alternatively, nerve 35 may be placed with a gap between transected nerve end 37 and longitudinal electrode array 38 such that neural regeneration occurs from transected nerve end 37 toward and in close proximity to elements of longitudinal electrode array 38.

[0070] FIG. 9 depicts longitudinal electrode regeneration port neuromodulatory interface 119, an improved design for neuromodulatory interface 34 included in the present invention. Nerve 35 is shown inserted into nerve cuff 36. For selective afferent stimulation, the nerve 35 is transected prior to surgical insertion into nerve cuff 36. Longitudinal electrode array 38 is mounted within nerve cuff 36 and in contact or close proximity to nerve 35. Connecting wire array 40 provides electrical connection from each element of longitudinal electrode array 38 to connecting cable 55. Nerve cuff end plate 41 is attached to the distal end of nerve cuff 36. Nerve 35 may be advanced sufficiently far into longitudinal electrode array 38 such that elements of longitudinal electrode array 38 penetrate into nerve 35. Alternatively, nerve 35 may be placed with a gap between transected nerve end 37 and longitudinal electrode array 38 such that neural regeneration occurs from transected nerve end 37 toward and in close proximity to elements of longitudinal electrode array 38. At least one of nerve cuff 36 and nerve cuff end plate 41 are perforated with one or a multiplicity of regeneration port 39 to facilitate and enhance regeneration of nerve fibers from transected nerve end 37.

[0071] FIG. 10 depicts regeneration tube neuromodulatory interface 120, an advanced design for neuromodulatory interface 34 included in the present invention. Nerve 35 is shown inserted into nerve cuff 36. For selective afferent stimulation, the nerve 35 is transected prior to surgical insertion into nerve cuff 36. Regeneration electrode array 44 is mounted within regeneration tube array 42, which is contained within nerve cuff 36. Each regeneration tube 43 contains at least one element of regeneration electrode array 44. Each element of regeneration electrode array 44 is electrically connected by at least one element of connecting wire array 40 to connecting cable 55. Nerve 35 may be surgically inserted into nerve cuff 36 sufficiently far to be adjacent to regeneration tube array 42 or may be placed with a gap between transected nerve end 37 and regeneration tube array 42. Neural regeneration occurs from transected nerve end 37 toward and through regeneration tube 43 elements regeneration tube array 42.

[0072] The present invention further includes stimulation of other tissues that influence vagus nerve activity. These include tissues of the esophagus, stomach, small and large intestine, pancreas, liver, gallbladder, kidney, mesentery, appendix, bladder, uterus, and other intraabdominal tissues. Stimulation of one or a multiplicity of these tissues modulates activity of the vagus nerve afferent fibers without significantly altering activity of efferent fibers. This method and the associated apparatus facilitates the stimulation of vagus nerve afferent fibers without activating vagus nerve efferent fibers, thereby overcoming the ulcerogenic and cardiac side effects of nonselective vagus nerve stimulation. This represents a major advance in vagus nerve modulation and overcomes the potentially life-threatening complications of nonselective stimulation of the vagus nerve.

[0073] A4b. Parasympathetic Stimulation—Other. The present invention teaches stimulation of the cervical nerves or their roots or branches for modulation of the parasympathetic nervous system. Additionally, the present invention teaches stimulation of the sacral nerves or their roots or branches for modulation of the parasympathetic nervous system.

[0074] A5. Multichannel Satiety Modulation. FIG. 6 depicts apparatus and method for performing multichannel modulation of satiety. Implantable pulse generator 1 is attached to stomach 8, via attachment means 6 and 7 connected from stomach 8 to attachment fixture 4 and 5, respectively. Implantable pulse generator 1 is electrically connected via modulator cable 32 to modulators 24, 25, 26, 27, 28, and 29, which are affixed to the stomach 8 preferably along the region of the greater curvature of stomach 10. Implantable pulse generator 1 is additionally electrically connected via modulator cable 33 to modulators 30 and 31, which are affixed to the stomach 8 preferably along the region of the lesser curvature of stomach 17. Implantable pulse generator 1 is furthermore electrically connected via modulator cable 18 and 19 to modulators 2 and—3, respectively, which are affixed to the gastric pylorus 12. Modulator 2 is affixed to gastric pylorus via modulator attachment fixture 22 and 23, and modulator 3 is affixed to gastric pylorus via modulator attachment fixture 20 and 21.

[0075] Using the apparatus depicted in FIG. 6, satiety modulation is achieved through multiple modalities. A multiplicity of modulators, including modulator 30 and 31 facilitate stimulation of vagus and sympathetic afferent fibers directly, as well as through stimulation of tissues, including gastric muscle, that in turn influence activity of the sympathetic and vagus afferent fibers. A multiplicity of modulators, including modulator 24, 25, 26, 27, 28, and 29 facilitate stimulation of sympathetic afferent fibers directly, as well as through stimulation of tissues, including gastric muscle, that in turn influence activity of the sympathetic fibers. Any of these modulators may be used to modulate vagus nerve activity; however, one advancement taught in the present invention is the selective stimulation of sympathetic nerve fiber activation, and this is facilitated by modulators 24, 25, 26, 27, 28, and 29, by virtue of their design for and anatomical placement in regions of the stomach 8 that are not innervated by the vagus nerve or its branches.

[0076] In addition to the apparatus and methods depicted in FIG. 6 for satiety modulation, the present invention further includes satiety modulation performed with the apparatus depicted in FIG. 16, and described previously, using stimulation of right sympathetic trunk 71, left sympathetic trunk 72, right greater splanchnic nerve 73, left greater splanchnic nerve 74, right lesser splanchnic nerve 75, left lesser splanchnic nerve 76 or other branch or the sympathetic nervous system.

[0077] B. Metabolic Modulation B.1. Sympathetic Efferent Stimulation. One objective of the modulator configuration employed in the present invention is the selected stimulation of sympathetic efferent nerve fibers. The present invention includes a multiplicity of potential modulator configurations and combinations of thereof. The present embodiment includes modulators placed at a combination of sites to interface with the sympathetic efferent fibers. These sites include the musculature of the stomach, the distal sympathetic branches penetrating into the stomach, postganglionic axons and cell bodies, preganglionic axons and cell bodies, the sympathetic chain and portions thereof, the intermediolateral nucleus, the locus ceruleus, the hypothalamus, and other structures comprising or influencing activity of the sympathetic nervous system.

[0078] Stimulation of the sympathetic efferents is performed to elevate the metabolic rate and lipolysis in the adipose tissue, thereby enhancing breakdown of fat and weight loss in the patient.

[0079] B.1.a. Sympathetic Efferent Stimulation Sympathetic Trunk. FIGS. 14, 15, and 16 depict apparatus for stimulation of the sympathetic nervous system. FIG. 14 depicts a subset of anatomical locations for placement of neuromodulatory interfaces for modulation of the sympathetic nervous system. FIG. 15 depicts the same apparatus with the further addition of a set of implantable pulse generator 1 and connecting cables. FIG. 16 depicts the apparatus shown in FIG. 15 with the further addition of gastric modulation apparatus also depicted in FIG. 6.

[0080] FIG. 13 reveals the normal anatomy of the thoracic region. Trachea 63 is seen posterior to aortic arch 57. Brachiocephalic artery 59, left common carotid artery—60 arise from aortic arch 57, and left subclavian artery 61 arises from the left common carotid artery 60. Right mainstem bronchus 64 and left mainstem bronchus 65 arise from trachea 63. Thoracic descending aorta 58 extends from aortic arch 57 and is continuous with abdominal aorta 62. Right vagus nerve 95 and left vagus nerve 96 are shown. Intercostal nerve 69 and 70 are shown between respective pairs of ribs, of which rib 67 and rib 68 are labeled.

[0081] Right sympathetic trunk 71 and left sympathetic trunk are lateral to mediastinum 82. Right greater splanchnic nerve 73 and right lesser splanchnic nerve 75 arise from right sympathetic trunk 71. Left greater splanchnic nerve 74 and left lesser splanchnic nerve 76 arise from left sympathetic trunk 72. Right subdiaphragmatic greater splanchnic nerve 78, left subdiaphragmatic greater splanchnic nerve 79, right subdiaphragmatic lesser splanchnic nerve 80, and left subdiaphragmatic lesser splanchnic nerve 81 are extensions below the diaphragm 77 of the right greater splanchnic nerve 73, left greater splanchnic nerve 74, right lesser splanchnic nerve 75, and left lesser splanchnic nerve 76, respectively.

[0082] B.1.b. Sympathetic Efferent Stimulation—Splanchnics. FIG. 14 depicts multichannel sympathetic modulation implanted with relevant anatomical structures. Sympathetic trunk neuromodulatory interface 83 and 85 are implanted adjacent to and in communication with right sympathetic trunk 71. Sympathetic trunk neuromodulatory interface 84 and 86 are implanted adjacent to and in communication with left sympathetic trunk 72. Sympathetic trunk neuromodulatory interface 83, 84, 85, and 86 are implanted superior to their respective sympathetic trunk levels at which the right greater splanchnic nerve 73, left greater splanchnic nerve 74, right lesser splanchnic nerve 75, and left lesser splanchnic nerve 76, arise, respectively.

[0083] Thoracic splanchnic nerve interface 87, 88, 89, 90 are implanted adjacent to and in communication with the right greater splanchnic nerve 73, left greater splanchnic nerve 74, right lesser splanchnic nerve 75, and left lesser splanchnic nerve 76, arise, respectively. Abdominal splanchnic nerve interface 91, 92, 93, and 94 are implanted adjacent to and in communication with the right subdiaphragmatic greater splanchnic nerve 78, left subdiaphragmatic greater splanchnic nerve 79, right subdiaphragmatic lesser splanchnic nerve 80, and left subdiaphragmatic lesser splanchnic nerve 81, respectively.

[0084] Stimulation of at least one of right sympathetic trunk 71, left sympathetic trunk 72, right greater splanchnic nerve 73, left greater splanchnic nerve 74, right lesser splanchnic nerve 75, and left lesser splanchnic nerve 76, right subdiaphragmatic greater splanchnic nerve 78, left subdiaphragmatic greater splanchnic nerve 79, right subdiaphragmatic lesser splanchnic nerve 80, and left subdiaphragmatic lesser splanchnic nerve 81 enhances metabolism of adipose tissue. Stimulation of these structures may be performed using at least one of electrical energy, electrical fields, optical energy, mechanical energy, magnetic energy, chemical compounds, pharmacological compounds, thermal energy, vibratory energy, or other means for modulating neural activity.

[0085] FIG. 15 depicts the implanted neuromodulatory interfaces as in FIG. 14, with the addition of the implanted pulse generators. Implantable pulse generator 99 is connected via connecting cable 103, 105, 107, 109, 115, to sympathetic trunk neuromodulatory interface 83 and 85, and thoracic splanchnic neuromodulatory interface 87 and 89, and vagus neuromodulatory interface 97, respectively. Implantable pulse generator 100 is connected via connecting cable 104, 106, 108, 110, 116, to sympathetic trunk neuromodulatory interface 83 and 85, and thoracic splanchnic neuromodulatory interface 88 and 90, and vagus neuromodulatory interface 98, respectively. Implantable pulse generator 101 is connected via connecting cable 111 and 113 to abdominal splanchnic neuromodulatory interface 91 and 93, respectively. Implantable pulse generator 102 is connected via connecting cable 112 and 114 to abdominal splanchnic neuromodulatory interface 92 and 94, respectively.

[0086] B.1.c. Sympathetic Efferent Stimulation—Spinal Cord. FIGS. 17 and 18 depicts the normal cross sectional anatomy of the spinal cord 151 and anatomy with implanted neuromodulatory interfaces, respectively.

[0087] FIG. 17 depicts the normal anatomical structures of the spinal cord 151, including several of its component structures such as the intermediolateral nucleus 121, ventral horn of spinal gray matter 141, dorsal horn of spinal gray matter 142, spinal cord white matter 122, anterior median fissure 123. Other structures adjacent to or surrounding spinal cord 151 include ventral spinal root 124, dorsal spinal root 125, spinal ganglion 126, spinal nerve 127, spinal nerve anterior ramus 128, spinal nerve posterior ramus 129, gray ramus communicantes 130, white ramus communicantes—131, sympathetic trunk 132, pia mater 133, subarachnoid space 134, arachnoid 135, meningeal layer of dura mater 136, epidural space 137, periosteal layer of dura mater—138, and vertebral spinous process 139, and vertebral facet 140.

[0088] FIG. 17 depicts the normal anatomy of the spinal cord seen in transverse section. Spinal cord and related neural structures include intermediolateral nucleus 121, spinal cord white matter 122, anterior median fissure 123, ventral spinal root 124, dorsal spinal root 125, spinal ganglion 126, spinal nerve 127, spinal nerve anterior ramus 128, spinal nerve posterior ramus 129, grey ramus communicantes 130, white ramus communicantes 131, sympathetic trunk 132, pia mater 133, subarachnoid space 134, arachnoid 135, meningeal layer of dura 136, epidural space 137, periostial layer of dura mater 138, vertebral spinous process 139, vertebral facet 140, ventral horn of spinal gray matter 141, and dorsal horn of spinal gray matter 142.

[0089] FIG. 18 depicts the spinal neuromodulatory interfaces positioned in the vicinity of spinal cord 151. Neuromodulatory interfaces positioned anterior to spinal cord 151 include anterior central spinal neuromodulatory interface 143, anterior right lateral spinal neuromodulatory interface 144, and anterior left lateral spinal neuromodulatory interface 145. Neuromodulatory interfaces positioned posterior to spinal cord 151 include posterior central spinal neuromodulatory interface 146, posterior right lateral spinal neuromodulatory interface 147, and posterior left lateral spinal neuromodulatory interface 148. Neuromodulatory interfaces positioned lateral to spinal cord 151 include right lateral spinal neuromodulatory interface 149 and left lateral spinal neuromodulatory interface 150. Neuromodulatory interfaces positioned within the spinal cord 151 include intermediolateral nucleus neuromodulatory interface—152.

[0090] Stimulation, inhibition, or other modulation of the spinal cord 151 is used to modulate fibers of the sympathetic nervous system, including those in the intermediolateral nucleus 121 and efferent and efferent fibers connected to the intermediolateral nucleus 121. Modulation of at least one of portions of the spinal cord—151, intermediolateral nucleus 121, ventral spinal root 124, dorsal spinal root 125, spinal ganglion 126, spinal nerve 127, gray ramus communicantes 130, white ramus communicantes 131 and other structures facilitates modulation of activity of the sympathetic trunk 132. Modulation of activity of the sympathetic trunk 132, in turn, is used to modulate at least one of metabolic activity, satiety, and appetite. This may be achieved using intermediolateral nucleus neuromodulatory interface 152, placed in or adjacent to the intermediolateral nucleus 121. The less invasive design employing neuromodulatory interfaces (144, 145, 146, 147, 148, 149, 150) shown positioned in the in epidural space 137 is taught in the present invention.

[0091] B.1.d. Sympathetic Efferent Stimulation—Other. The present invention further includes modulation of all sympathetic efferent nerves, nerve fibers, and neural structures. These sympathetic efferent neural structures include but are not limited to distal sympathetic nerve branches, mesenteric nerves, sympathetic efferent fibers at all spinal levels, rami communicantes at all spinal levels, paravertebral nuclei, prevertebral nuclei, and other sympathetic structures.

[0092] B.2. Noninvasive Stimulation. The present invention teaches a device for metabolic control using tactile stimulation. Tactile stimulation of afferent neurons causes alterations in activity of sympathetic neurons which influence metabolic activity of adipose tissue. The present invention teaches tactile stimulation of skin, dermal and epidermal sensory structures, subcutaneous tissues and structures, and deeper tissues to modulate activity of afferent neurons.

[0093] This device for metabolic control employs vibratory actuators. Alternatively, electrical stimulation, mechanical stimulation, optical stimulation, acoustic stimulation, pressure stimulation, and other forms of energy that modulate afferent neural activity, are used.

[0094] C. Multimodal Metabolic Modulation. To maximize efficacy while tailoring treatment to minimize side effects, the preferred embodiment includes a multiplicity of treatment modalities, including afferent, efferent, and neuromuscular modulation.

[0095] Afferent signals are generated to simulate satiety. This is accomplished through neural, neuromuscular, and hydrostatic mechanisms. Electrical stimulation of the vagus via vagus nerve interface 45 afferents provides one such channel to transmit information to the central nervous system for the purpose of eliciting satiety. Electrical stimulation of the sympathetic afferents via sympathetic nerve interface 46 provides another such channel to transmit information to the central nervous system for the purpose of eliciting satiety. Electrical stimulation of gastric circular muscle layerln FIG. 11, multimodal stimulation is depicted, including stimulation of gastric musculature using modulators 2 and 3, as well as stimulation of afferent fibers of the proximal stump of vagus nerve 47 using vagus nerve modulator 45 and stimulation of afferent fibers of sympathetic nerve branch 48.

[0096] In FIG. 12, expanded multimodal stimulation is depicted, including those modalities shown in FIG. 11, including stimulation of gastric musculature using modulators 2 and 3, as well as stimulation of afferent fibers of the proximal stump of vagus nerve 47 using vagus nerve modulator 45 and stimulation of afferent fibers of sympathetic nerve branch 48, in addition to those modalities shown in FIG. 6, explained in detail above, including modulation of gastric muscular fibers, sympathetic afferent fibers innervating gastric tissues, and vagus afferent fibers innervating gastric tissues.

[0097] In FIG. 16, further expanded multimodal modulation is depicted, including modalities encompassed and described above and depicted in FIG. 15 and FIG. 12. This includes modulation of gastric muscle fibers, fibers of the sympathetic nerve branch 48 and vagus nerve 47 that innervate gastric tissues, and a multiplicity of structures in the sympathetic nervous system and vagus nerve 47.

[0098] E. System/Pulse Generator Design. Neuromodulatory interfaces that use electrical energy to modulate neural activity may deliver a broad spectrum of electrical waveforms. One preferred set of neural stimulation parameter sets includes pulse frequencies ranging from 0.1 Hertz to 1000 Hertz, pulse widths from 1 microsecond to 500 milliseconds. Pulses are charge balanced to insure no net direct current charge delivery. The preferred waveform is bipolar pulse pair, with an interpulse interval of 1 microsecond to 1000 milliseconds. Current regulated stimulation is preferred and includes pulse current amplitudes ranging from 1 microamp to 1000 milliamps. Alternatively, voltage regulation may be used, and pulse voltage amplitudes ranging from 1 microvolt to 1000 volts. These parameters are provide as exemplary of some of the range include in the present invention; variation from these parameter sets are include in the present invention.

Claims

The invention claimed is:

1. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic trunk to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a sympathetic trunk neuromodulatory interface in communication with said implantable pulse generator via said connecting cable.

2. A device as in claim 1, wherein said electrode reversibly modulates a component of the sympathetic nervous system.

3. A device as in claim 1, wherein the disease being treated is obesity.

4. A device as in claim 1, wherein the disease being treated is obesity.

5. A device as in claim 1, wherein the disease being treated is elevated body mass index.

6. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to treat obesity.

7. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to treat metabolic disease.

8. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to treat diabetes.

9. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to influence satiety.

10. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to influence food intake.

11. A device as in claim 1, wherein said modulator modulates activity of the sympathetic nervous system to control metabolism.

12. A device as in claim 1, wherein said modulator comprises at least one electrode.

13. A device as in claim 1, wherein said modulator comprises at least one energy emitter.

14. A device as in claim 1, wherein said modulator comprises a nerve cuff.

15. A device as in claim 1, wherein said modulator comprises at least one pharmaceutical delivery means.

16. A device as in claim 1, wherein neuromodulatory interface delivers a signal which increases sympathetic activity and causes body weight to be reduced.

17. A device as in claim 1, wherein neuromodulatory interface delivers a signal which decreases sympathetic activity and causes body weight to be increased.

18. A device as in claim 1, wherein neuromodulatory interface delivers a signal which modulates sympathetic activity and causes body weight to be controlled.

19. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a thoracic splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

20. A device as in claim 19, wherein said electrode modulates cells of the sympathetic nervous system.

21. A device as in claim 19, whereby the disease being treated is obesity.

22. A device as in claim 19, wherein the disease being treated is obesity.

23. A device as in claim 19, wherein the disease being treated is elevated body mass index.

24. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat obesity.

25. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat metabolic disease.

26. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat diabetes.

27. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to influence satiety.

28. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to influence food intake.

29. A device as in claim 19, wherein said modulator is configured to modulate activity of the sympathetic nervous system to control metabolism.

30. A device as in claim 19, wherein said modulator comprises at least one electrode.

31. A device as in claim 19, wherein said modulator comprises at least one energy emitter.

32. A device as in claim 19, wherein said modulator comprises a nerve cuff.

33. A device as in claim 19, wherein said modulator comprises at least one pharmaceutical delivery means.

34. A device as in claim 19, wherein neuromodulatory interface delivers a signal which increases sympathetic activity and causes body weight to be reduced.

35. A device, as in claim 19, wherein neuromodulatory interface delivers a signal which decreases sympathetic activity and causes body weight to be increased.

36. A device as in claim 19, wherein neuromodulatory interface delivers a signal which modulates sympathetic activity and causes body weight to be controlled.

37. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises an abdominal splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

38. A device as in claim 37, wherein said electrode modulates fibers of the sympathetic nervous system.

39. A device as in claim 37, wherein the disease being treated is obesity.

40. A device as in claim 37, wherein the disease being treated is obesity.

41. A device as in claim 37, wherein the disease being treated is elevated body mass index.

42. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat obesity.

43. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat metabolic disease.

44. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat diabetes.

45. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to influence satiety.

46. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to influence food intake.

47. A device as in claim 37, wherein said modulator is configured to modulate activity of the sympathetic nervous system to control metabolism.

48. A device as in claim 37, wherein said modulator comprises at least one electrode.

49. A device as in claim 37, wherein said modulator comprises at least one energy emitter.

50. A device as in claim 37, wherein said modulator comprises a nerve cuff.

51. A device as in claim 37, wherein said modulator comprises at least one pharmaceutical delivery means.

52. A device as in claim 37, wherein neuromodulatory interface delivers a signal which increases sympathetic activity and causes body weight to be reduced.

53. A device as in claim 37, wherein neuromodulatory interface delivers a signal which decreases sympathetic activity and causes body weight to be increased.

54. A device as in claim 37, wherein neuromodulatory interface delivers a signal which modulates sympathetic activity and causes body weight to be controlled.

55. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator, and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers said signal.

56. A device as in claim 55, wherein the disease being treated is obesity.

57. A device as in claim 55, wherein the disease being treated is elevated body mass index.

58. A device as in claim 55, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat obesity.

59. A device as in claim 55, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat metabolic disease.

60. A device as in claim 55, wherein said modulator is configured to modulate activity of the sympathetic nervous system to treat diabetes.

61. A device as in claim 55, wherein by said modulator is configured to modulate activity of the sympathetic nervous system to influence satiety.

62. A device as in claim 55, wherein by said modulator is configured to modulate activity of the sympathetic nervous system to influence food intake.

63. A device as in claim 55, wherein by said modulator is configured to modulate activity of the sympathetic nervous system to control metabolism.

64. A device as in claim 55, wherein said modulator comprises at least one electrode.

65. A device as in claim 55, wherein said modulator comprises at least one energy emitter.

66. A device as in claim 55, wherein said modulator comprises a nerve cuff.

67. A device as in claim 55, wherein said modulator comprises at least one pharmaceutical delivery means.

68. A device as in claim 55, wherein body weight is reduced.

69. A device as in claim 55, wherein body weight is increased.

70. A device as in claim 55, wherein body weight is controlled.

71. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic neurons to induce weight loss;

(B) a conducting member attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said conducting member and which delivers reversible modulation to neurons of the sympathetic nervous system.

72. The device for treating disease as in claim 71 wherein said modulator is in communication with intermediolateral neurons.

73. The device for treating disease as in claim 71 wherein said modulator is in communication with the intermediolateral nucleus.

74. The device for treating disease as in claim 71 wherein said modulator is in communication with thoracic intermediolateral neurons.

75. The device for treating disease as in claim 71 wherein said modulator is in communication with the abdominal intermediolateral neurons.

76. The device for treating disease as in claim 71 wherein said modulator is configured to modulate neural activity for the treatment of obesity.

77. The device for treating disease as in claim 71 wherein said modulator is configured to modulate neural activity for the control of metabolism.

78. The device for treating disease as in claim 71 wherein said modulator is configured to modulate neural activity for the control of body weight.

79. The device for treating disease as in claim 71 wherein said modulator delivers electrical energy.

80. The device for treating disease as in claim 71 wherein said modulator comprises an anterior central spinal neuromodulatory interface.

81. The device for treating disease as in claim 71 wherein said modulator comprises an anterior right lateral spinal neuromodulatory interface.

82. The device for treating disease as in claim 71 wherein said modulator comprises an anterior left lateral spinal neuromodulatory interface.

83. The device for treating disease as in claim 71 wherein said modulator comprises a posterior central spinal neuromodulatory interface.

84. The device for treating disease as in claim 71 wherein said modulator comprises a posterior right lateral spinal neuromodulatory interface.

85. The device for treating disease as in claim 71 wherein said modulator comprises a posterior left lateral spinal neuromodulatory interface.

86. The device for treating disease as in claim 71 wherein said modulator comprises a right lateral spinal neuromodulatory interface.

87. The device for treating disease as in claim 71 wherein said modulator comprises a left lateral spinal neuromodulatory interface.

88. A device for treating a condition in a user, comprising:

(A) a pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss;

(B) a signal transmitting member, configured to transmit said signal from said pulse generator to a modulator; and

(C) the modulator, wherein said modulator delivers said signal to at least a component of the user's sympathetic nervous system.

89. The device as in claim 88, wherein said condition is obesity.

90. The device as in claim 88, wherein said condition is elevated body mass index.

91. The device as in claim 88, wherein said condition is anorexia.

92. The device as in claim 88, wherein body weight is controlled.

93. The device as in claim 88, wherein body weight is reduced.

94. The device as in claim 88, wherein body weight is increased.

95. The device as in claim 88, wherein satiety is influenced.

96. The device as in claim 88, wherein food intake is reduced.

97. The device as in claim 88, wherein metabolic rate is increased.

98. The device as in claim 88, wherein said modulator delivers a pharmaceutical agent.

99. A device as in claim 88, wherein said modulator is configured to modulate fibers of the sympathetic nervous system.

100. A device as in claim 88, wherein said modulator is configured to modulate cells of the sympathetic nervous system.

101. A device as in claim 88, wherein said modulator is configured to modulate at least one ganglia of the sympathetic nervous system.

102. A device as in claim 88, wherein said modulator is configured to modulate at least one portion of the sympathetic trunk.

103. A device as in claim 88, wherein said modulator is configured to modulate at least one portion of the greater splanchnic nerve.

104. A device as in claim 88, wherein said modulator is configured to modulate at least one portion of the lesser splanchnic nerve.

105. A device as in claim 88, wherein said modulator is configured to modulate at least one portion of the spinal cord.

106. A device as in claim 105, wherein said modulator is configured to modulate at least a portion of at least one level of the spinal cord.

107. A device as in claim 106, wherein said modulator is configured to modulate at least one level of the spinal cord.

108. A device as in claim 106, wherein said modulator is configured to modulate at least one region of the spinal cord.

109. A device as in claim 106, wherein said modulator is configured to modulate at least two regions of the spinal cord.

110. A device as in claim 106, wherein said modulator is configured to modulate at least two levels of the spinal cord.

111. A device as in claim 106, wherein said modulator is configured to modulate at least three levels of the spinal cord.

112. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T1 of the spinal cord.

113. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T2 of the spinal cord.

114. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T3 of the spinal cord.

115. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T4 of the spinal cord.

116. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T5 of the spinal cord.

117. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T6 of the spinal cord.

118. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T7 of the spinal cord.

119. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T8 of the spinal cord.

120. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T9 of the spinal cord.

121. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T10 of the spinal cord.

122. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T11 of the spinal cord.

123. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of thoracic level T12 of the spinal cord.

124. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of lumbar level L1 of the spinal cord.

125. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of lumbar level L2 of the spinal cord.

126. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of lumbar level L3 of the spinal cord.

127. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of lumbar level L4 of the spinal cord.

128. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of lumbar level L5 of the spinal cord.

129. A device as in claim 106, wherein said modulator is configured to modulate at least a portion of a thoracic level and a lumbar level of the spinal cord.

130. A device as in claim 106, wherein said modulator is configured to modulate at least one portion of a thoracic level of the spinal cord.

131. A device as in claim 106, wherein said modulator is configured to modulate at least one portion of a lumbar level of the spinal cord.

132. A device as in claim 106, wherein said modulator is configured to modulate afferent sympathetic fibers in at least one level of the spinal cord.

133. A device as in claim 106, wherein said modulator is configured to modulate efferent sympathetic fibers in at least one level of the spinal cord.

134. A device as in claim 106, wherein said modulator is configured to modulate afferent and efferent sympathetic fibers.

135. A device as in claim 106, wherein said modulator comprises an array of at least one modulator.

136. A device as in claim 106, wherein at least one modulator modulates afferent sympathetic fibers and at least one modulator modulates efferent sympathetic fibers.

137. A device as in claim 106, wherein at least one modulator modulates afferent sympathetic neurons and at least one modulator modulates efferent sympathetic neurons.

138. A device as in claim 106, wherein at least one modulator modulates afferent sympathetic pathways and at least one modulator modulates efferent sympathetic pathways.

139. A device as in claim 88, wherein said modulator is configured to modulate at least one portion of the intermediolateral nucleus.

140. A device as in claim 88, wherein said signal transmitting member comprises a connecting cable.

141. A device as in claim 88, wherein said signal transmitting member comprises a conducting member.

142. A device as in claim 88, wherein said signal transmitting member comprises a pulse transmitting member.

143. The device in claim 88, wherein said modulator delivers an electrical signal with pulse frequency between approximately 0.1 Hertz and approximately 1000 Hertz.

144. The device in claim 88, wherein said modulator delivers an electrical signal with pulse width between approximately 1 microsecond and approximately 1000 milliseconds.

145. The device in claim 88, wherein said modulator delivers an electrical signal with approximately zero net direct current charge delivery.

146. The device in claim 88, wherein said modulator delivers an electrical signal comprising a bipolar pulse pair.

147. The device in claim 88, wherein said modulator delivers an electrical signal with an interpulse interval of approximately 1 microsecond to 1000 milliseconds.

148. The device in claim 88, wherein said modulator delivers an electrical signal which is current regulated.

149. The device in claim 88, wherein said modulator delivers an electrical signal which is between approximately 1 microamp and 1000 milliamps.

150. The device in claim 88, wherein said modulator delivers an electrical signal which is voltage regulated.

151. The device in claim 88, wherein said modulator delivers an electrical signal which is between approximately 1 microvolt and 1000 volts.

152. A device for treating a condition in a user, comprising:

(A) a pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss;

(B) a signal transmitting member, configured to transmit said signal from said pulse generator to a modulator; and

(C) the modulator, wherein said modulator delivers at least one modality of energy to at least a component of the user's sympathetic nervous system.

153. The device as in claim 152, wherein said modulator delivers electrical energy.

154. The device as in claim 152, wherein said modulator delivers a signal which reversibly alters neural activity.

155. A device for modulating a user's nervous system, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a stimulating or modulating energy which modulates the sympathetic nervous system to induce weight loss;

(B) a signal transmitting member attached to said implantable pulse generator and configured to transmit generated stimulating or modulating energy; and

(C) a modulator which is configured to deliver stimulating or modulating energy from the signal transmitting member to communicate with at least one component of the user's sympathetic nervous system.

156. The device of claim 155, wherein said modulator is configured to communicate with afferent fibers of the user's sympathetic nervous system.

157. The device of claim 155, wherein said modulator is configured to communicate with efferent fibers of the user's sympathetic nervous system.

158. The device of claim 155, wherein said modulator is configured to communicate with a portion of the sympathetic trunk of the user's sympathetic nervous system.

159. The device of claim 155, wherein said modulator is configured to communicate with a portion of the greater splanchnic nerve of the user's sympathetic nervous system.

160. The device of claim 155, wherein said modulator is configured to communicate with a portion of the lesser splanchnic nerve of the user's sympathetic nervous system.

161. The device of claim 155, wherein said modulator is configured to communicate with a portion of the sympathetic nervous system in the spinal cord of the user.

162. The device of claim 155, wherein said modulator is configured to communicate with a portion of the intermediolateral nucleus of the user's sympathetic nervous system.

163. The device of claim 155, wherein said modulator is configured to communicate with a portion of the grey ramus communicantes.

164. The device of claim 155, wherein said modulator is configured to communicate with a portion of the white ramus communicantes.

165. The device of claim 155, wherein said modulator is configured to communicate with a portion of a spinal root.

166. The device of claim 155, wherein said modulator is configured to communicate with a portion of a spinal ganglion.

167. The device of claim 155, wherein said modulator is configured to communicate with a component of a spinal nerve.

168. The device of claim 155, wherein said modulator comprises an intermediolateral nucleus neuromodulatory interface.

169. The device of claim 155, wherein said modulator is configured to be positioned in the epidural space.

170. The device of claim 155, wherein said modulator is configured to be positioned in the subdural space.

171. The device of claim 155, wherein said modulator is configured to be positioned in the subarachnoid space.

172. The device of claim 155, wherein said modulator is configured to be positioned in the intraparenchymal space.

173. The device of claim 155, wherein said modulator is configured to be in communication with the intermediolateral nucleus.

174. The device of claim 155, wherein said modulator is configured to be in communication with the sympathetic trunk.

175. The device of claim 155, wherein said modulator is configured to be in communication with the greater splanchnic nerve.

176. The device of claim 155, wherein said modulator is configured to be in communication with the lesser splanchnic nerve.

177. The device of claim 155, wherein said modulator is configured to be in direct communication with a component of the sympathetic nervous system.

178. The device of claim 155, wherein said modulator is configured to be in indirect communication with a component of the sympathetic nervous system.

179. The device of claim 155, wherein afferent fibers of sympathetic nervous system are selectively stimulated.

180. The device of claim 155, wherein efferent fibers of sympathetic nervous system are selectively stimulated.

181. The device of claim 155, wherein said modulator interfaces with a transected nerve.

182. The device of claim 155, wherein said modulator is a nerve cuff.

183. The device of claim 155, comprising at least one modulator.

184. The device of claim 183, wherein said at least one modulator delivers more than one modality of signal.

185. The device of claim 155, wherein at least one modulator delivers multimodal stimulation.

186. The device of claim 155, wherein at least one of said modulator delivers modulating signal to at least one of gastric muscle fibers, fibers of the sympathetic nerve branch, vagus nerve, other sympathetic nervous system structures, and other parasympathetic nervous system structures.

187. The device of claim 155, wherein depression is also treated.

188. A device for modulating a patient's nervous system for the control of body weight, comprising:

(A) a pulse generator comprising a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss;

(B) a signal transmission member attached to said pulse generator and configured to transmit said signal; and

(C) a modulator which is adapted to receive said signal from the signal transmission member and which is configured to communicate with at least a portion of the patient's spinal cord.

189. The device in claim 188, wherein said device delivers said modulating signal to a portion of the spinal cord for the treatment of obesity.

190. The device in claim 188, wherein said device delivers said modulating signal to a portion of the spinal cord for the treatment of morbid obesity.

191. The device in claim 188, wherein said device delivers said modulating signal to a portion of the spinal cord for the reduction of body weight.

192. The device in claim 191, wherein said modulator delivers a signal which influences metabolism.

193. The device in claim 191, wherein said modulator delivers a signal which influences lipolysis.

194. The device in claim 191, wherein said modulator is configured to modulate the activity of efferent fibers of the sympathetic nervous system.

195. The device in claim 191, wherein said modulator is configured to alter the activity of at least a portion of the sympathetic nervous system.

196. The device in claim 188, wherein said modulator is in communication with at least a portion of the sympathetic nervous system.

197. The device in claim 196, wherein said modulator is in communication with at least a portion of the intermediolateral nucleus.

198. The device in claim 196, wherein said modulator is implanted.

199. The device in claim 196, wherein said modulator is configured to modulate the activity of at least a portion of the sympathetic nervous system.

200. The device in claim 188, wherein said device delivers said modulating signal to a portion of the spinal cord for the reduction of body fat.

201. The device in claim 188, wherein said device is implanted.

202. The device in claim 188, wherein said modulator is in communication with at least a portion of the intermediolateral nucleus.

203. The device in claim 188, wherein said modulator delivers a signal which influences satiety.

204. The device in claim 188, wherein said modulator delivers a signal which influences metabolism.

205. The device in claim 188, wherein said modulator delivers a signal which influences body weight.

206. The device in claim 188, wherein said modulator delivers a signal which influences body fat.

207. The device in claim 188, wherein said modulator delivers a signal which influences food intake.

208. The device in claim 188, wherein said modulator is configured to be positioned in the epidural space.

209. The device in claim 188, wherein said modulator is configured to be positioned in the subdural space.

210. The device in claim 188, wherein said modulator is configured to be positioned in the subarachnoid space.

211. The device in claim 188, wherein said modulator is configured to be positioned in the intraparenchymal space.

212. The device in claim 188, wherein said modulator delivers an electrical signal.

213. The device in claim 188, wherein said modulator delivers a signal which comprises at least one pulse.

214. The device in claim 188, wherein said modulator delivers an electrical signal with pulse frequency between approximately 0.1 Hertz and approximately 1000 Hertz.

215. The device in claim 188, wherein said modulator delivers an electrical signal with pulse width between approximately 1 microsecond and approximately 1000 milliseconds.

216. The device in claim 188, wherein said modulator delivers an electrical signal with approximately zero net direct current charge delivery.

217. The device in claim 188, wherein said modulator delivers an electrical signal comprising a bipolar pulse pair.

218. The device in claim 188, wherein said modulator delivers an electrical signal with an interpulse interval of approximately 1 microsecond to 1000 milliseconds.

219. The device in claim 188, wherein said modulator delivers an electrical signal which is current regulated.

220. The device in claim 188, wherein said modulator delivers an electrical signal which is between approximately 1 microamp and 1000 milliamps.

221. The device in claim 188, wherein said modulator delivers an electrical signal which is voltage regulated.

222. The device in claim 188, wherein said modulator delivers an electrical signal which is between approximately 1 microvolt and 1000 volts.

223. The device in claim 188, wherein said modulator delivers a signal which influences metabolic rate.

224. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of at least one level of the spinal cord.

225. A device as in claim 188, wherein said modulator is configured to modulate at least one level of the spinal cord.

226. A device as in claim 188, wherein said modulator is configured to modulate at least one region of the spinal cord.

227. A device as in claim 188, wherein said modulator is configured to modulate at least two regions of the spinal cord.

228. A device as in claim 188, wherein said modulator is configured to modulate at least two levels of the spinal cord.

229. A device as in claim 188, wherein said modulator is configured to modulate at least three levels of the spinal cord.

230. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T1 of the spinal cord.

231. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T2 of the spinal cord.

232. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T3 of the spinal cord.

233. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T4 of the spinal cord.

234. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T5 of the spinal cord.

235. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T6 of the spinal cord.

236. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T7 of the spinal cord.

237. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T8 of the spinal cord.

238. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T9 of the spinal cord.

239. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T10 of the spinal cord.

240. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T11 of the spinal cord.

241. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of thoracic level T12 of the spinal cord.

242. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of lumbar level L1 of the spinal cord.

243. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of lumbar level L2 of the spinal cord.

244. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of lumbar level L3 of the spinal cord.

245. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of lumbar level L4 of the spinal cord.

246. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of lumbar level L5 of the spinal cord.

247. A device as in claim 188, wherein said modulator is configured to modulate at least a portion of a thoracic level and a lumbar level of the spinal cord.

248. A device as in claim 188, wherein said modulator is configured to modulate at least one portion of a thoracic level of the spinal cord.

249. A device as in claim 188, wherein said modulator is configured to modulate at least one portion of a lumbar level of the spinal cord.

250. A device as in claim 188, wherein said modulator is configured to modulate afferent sympathetic fibers in at least one level of the spinal cord.

251. A device as in claim 188, wherein said modulator is configured to modulate efferent sympathetic fibers in at least one level of the spinal cord.

252. A device as in claim 188, wherein said modulator is configured to modulate afferent and efferent sympathetic fibers.

253. A device as in claim 188, wherein said modulator comprises an array of at least one modulator.

254. A device as in claim 188, wherein at least one modulator modulates afferent sympathetic fibers and at least one modulator modulates efferent sympathetic fibers.

255. A device as in claim 188, wherein at least one modulator modulates afferent sympathetic neurons and at least one modulator modulates efferent sympathetic neurons.

256. A device as in claim 188, wherein at least one modulator modulates afferent sympathetic pathways and at least one modulator modulates efferent sympathetic pathways.

257. The device in claim 188, wherein said modulator delivers a signal which influences appetite.

258. The device in claim 188, wherein said processor is configured to generate a signal which influences metabolic rate.

259. An Apparatus for reducing body weight in a user comprising:

(A) a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss; and

(B) a modulator configured to deliver said signal to sympathetic neurons.

260. The apparatus of claim 259, wherein said processor is configured to reduce body weight for the treatment of obesity.

261. The apparatus of claim 259, wherein said modulator is configured to modulate sympathetic efferent neurons.

262. The apparatus of claim 259, wherein said modulator is configured to modulate sympathetic afferent neurons.

263. The apparatus method of claim 259, wherein said modulator is configured to modulate neurons in the locus ceruleus.

264. The apparatus of claim 259, wherein said modulator is configured to modulate intermediolateral nucleus neurons.

265. The apparatus of claim 259, wherein said modulator is configured to modulate sympathetic trunk neurons.

266. The apparatus of claim 259, wherein said modulator is configured to modulate splanchnic nerve neurons.

267. The apparatus of claim 259, wherein said modulator is configured to modulate greater splanchnic nerve neurons.

268. The apparatus of claim 259, wherein said modulator is configured to modulate lesser splanchnic nerve neurons.

269. The apparatus of claim 259, wherein said modulator is configured to modulate thoracic splanchnic nerve neurons.

270. The apparatus of claim 259, wherein said modulator is configured to modulate thoracic greater splanchnic nerve neurons.

271. The apparatus of claim 259, wherein said modulator is configured to modulate thoracic lesser splanchnic nerve neurons.

272. The apparatus of claim 259, wherein said modulator is configured to modulate abdominal splanchnic nerve neurons.

273. The apparatus of claim 259, wherein said modulator is configured to modulate abdominal greater splanchnic nerve neurons.

274. The apparatus of claim 259, wherein said modulator is configured to modulate abdominal lesser splanchnic nerve neurons.

275. The apparatus of claim 259, wherein said modulator is configured to modulate a single or plurality of sympathetic neurons which further modulate activity of the locus ceruleus.

276. The apparatus of claim 259, wherein said modulator is configured to selectively modulate sympathetic afferent neurons.

277. The apparatus of claim 259, wherein said modulator is configured to selectively modulate sympathetic efferent neurons.

278. The apparatus of claim 259, wherein said modulator comprises a single or plurality of modulators configured to modulate multiple modalities.

279. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and sympathetic efferent neurons.

280. The apparatus method of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastric muscle tissue.

281. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastric pylorus muscle tissue.

282. The apparatus method of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastrointestinal tissue.

283. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord neurons.

284. The apparatus of claim 283, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and spinal cord neurons.

285. The apparatus of claim 283, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and spinal cord neurons.

286. The apparatus of claim 283, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord afferent neurons.

287. The apparatus of claim 283, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord efferent neurons.

288. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and muscle tissue.

289. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and muscle tissue.

290. The apparatus of claim 289, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastric muscle tissue.

291. The apparatus of claim 289, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastric pylorus muscle tissue.

292. The apparatus of claim 289, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastrointestinal tissue.

293. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic neurons.

294. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and somatic afferent neurons.

295. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and somatic efferent neurons.

296. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic afferent neurons.

297. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic efferent neurons.

298. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and somatic neurons.

299. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and somatic neurons.

300. The apparatus of claim 278, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and spinal cord neurons.

301. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates sympathetic efferent neurons.

302. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates sympathetic afferent neurons.

303. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates neurons in the locus ceruleus.

304. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates intermediolateral nucleus neurons.

305. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates sympathetic trunk neurons.

306. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates splanchnic nerve neurons.

307. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates greater splanchnic nerve neurons.

308. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates lesser splanchnic nerve neurons.

309. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates thoracic splanchnic nerve neurons.

310. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates thoracic greater splanchnic nerve neurons.

311. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates thoracic lesser splanchnic nerve neurons.

312. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates abdominal splanchnic nerve neurons.

313. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates abdominal greater splanchnic nerve neurons.

314. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates abdominal lesser splanchnic nerve neurons.

315. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates a single or plurality of sympathetic neurons which further modulate activity of the locus ceruleus.

316. The apparatus of claim 259, wherein said processor is configured to generate a signal which selectively modulates sympathetic afferent neurons.

317. The apparatus of claim 259, wherein said processor is configured to generate a signal which selectively modulates sympathetic efferent neurons.

318. The apparatus of claim 259, wherein said modulator is configured to modulate sympathetic spinal neurons.

319. The apparatus of claim 259, wherein said processor is configured to generate a signal which modulates sympathetic spinal neurons.

320. The apparatus of claim 259, wherein said processor is configured to generate a single or plurality of signals which modulate multiple modalities.

321. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and sympathetic efferent neurons.

322. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastric muscle tissue.

323. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastric pylorus muscle tissue.

324. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastrointestinal tissue.

325. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord neurons.

326. The apparatus of claim 325, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and spinal cord neurons.

327. The apparatus of claim 325, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and spinal cord neurons.

328. The apparatus of claim 325, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord afferent neurons.

329. The apparatus of claim 325, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord efferent neurons.

330. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and muscle tissue.

331. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and muscle tissue.

332. The apparatus of claim 331, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastric muscle tissue.

333. The apparatus of claim 331, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastric pylorus muscle tissue.

334. The apparatus of claim 331, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastrointestinal tissue.

335. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic neurons.

336. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and somatic afferent neurons.

337. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and somatic efferent neurons.

338. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic afferent neurons.

339. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic efferent neurons.

340. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and somatic neurons.

341. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and somatic neurons.

342. The apparatus of claim 320, wherein said processor is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord neurons.

343. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(A) pulse generator, in communication with a modulator, wherein pulse generator comprises a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss;

(B) the modulator, in communication with a portion of the sympathetic nervous system, wherein said modulator modulates afferent sympathetic neurons and a second modulator modulates efferent sympathetic neurons.

344. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(A) a pulse generator, in communication with a modulator; wherein pulse generator comprises a processor configured to generate a signal which modulates the sympathetic nervous system to induce weight loss; and

(B) the modulator, in communication with a portion of the sympathetic nervous system, wherein said modulator is configured to interface with a portion of the intermediolateral nucleus.

345. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(B) the modulator, in communication with a portion of the sympathetic nervous system, wherein said modulator is configured to control metabolism.

346. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(A) a pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic nervous system to control or influence appetite, in communication with a modulator; and

(B) the modulator, in communication with a portion of the sympathetic nervous system.

347. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(A) a pulse generator, comprising a processor configured to generate a signal which modulates the sympathetic nervous system to control or influence satiety, in communication with a modulator; and

(B) the modulator, in communication with a portion of the sympathetic nervous system.

348. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(B) the modulator, in communication with a portion of the sympathetic nervous system.

349. An apparatus for use in treating disease wherein fibers of the autonomic nervous system are stimulated, comprising:

(B) the modulator, in communication with a portion of the sympathetic nervous system.

350. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates the sympathetic trunk to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a sympathetic trunk neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

351. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a thoracic splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

352. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises an abdominal splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

353. A device for treating disease, comprising:

(A) an implantable pulse generator, wherein pulse generator comprises a processor configured to generate a signal which modulates the sympathetic trunk to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a sympathetic trunk neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

354. A device for treating disease, comprising:

(A) an implantable pulse generator, wherein pulse generator comprises a processor configured to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a thoracic splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

355. A device for treating disease, comprising:

(A) an implantable pulse generator, wherein pulse generator comprises a processor configured to generate a signal which modulates the splanchnic nerve to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises an abdominal splanchnic neuromodulatory interface connected to said implantable pulse generator via said connecting cable.

356. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers modulating signal.

357. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates afferents to the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers modulating signal.

358. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates afferents to the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers modulating signal.

359. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising a processor configured to generate a signal which modulates efferents from the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers modulating signal.

360. A device for treating disease, comprising:

(A) an implantable pulse generator, comprising memory containing instructions to generate a signal which modulates efferents from the spinal cord to induce weight loss;

(B) a connecting cable attached to said implantable pulse generator; and

(C) a modulator, wherein said modulator comprises a spinal neuromodulatory interface connected to said implantable pulse generator via said connecting cable, and which delivers modulating signal.

361. An Apparatus for reducing body weight in a user comprising:

(A) a controller configured to generate a signal which modulates the sympathetic nervous system to induce weight loss; and

(B) a modulator configured to deliver said signal to sympathetic neurons.

362. The apparatus of claim 361, wherein said controller is configured to reduce body weight for the treatment of obesity.

363. The apparatus of claim 361, wherein said modulator is configured to modulate sympathetic efferent neurons.

364. The apparatus of claim 361, wherein said modulator is configured to modulate sympathetic afferent neurons.

365. The apparatus of claim 361, wherein said modulator is configured to modulate neurons in the locus ceruleus.

366. The apparatus of claim 361, wherein said modulator is configured to modulate intermediolateral nucleus neurons.

367. The apparatus of claim 361, wherein said modulator is configured to modulate sympathetic trunk neurons.

368. The apparatus of claim 361, wherein said modulator is configured to modulate splanchnic nerve neurons.

369. The apparatus of claim 361, wherein said modulator is configured to modulate greater splanchnic nerve neurons.

370. The apparatus of claim 361, wherein said modulator is configured to modulate lesser splanchnic nerve neurons.

371. The apparatus of claim 361, wherein said modulator is configured to modulate thoracic splanchnic nerve neurons.

372. The apparatus of claim 361, wherein said modulator is configured to modulate thoracic greater splanchnic nerve neurons.

373. The apparatus of claim 361, wherein said modulator is configured to modulate thoracic lesser splanchnic nerve neurons.

374. The apparatus of claim 361, wherein said modulator is configured to modulate abdominal splanchnic nerve neurons.

375. The apparatus of claim 361, wherein said modulator is configured to modulate abdominal greater splanchnic nerve neurons.

376. The apparatus of claim 361, wherein said modulator is configured to modulate abdominal lesser splanchnic nerve neurons.

377. The apparatus of claim 361, wherein said modulator is configured to modulate a single or plurality of sympathetic neurons which further modulate activity of the locus ceruleus.

378. The apparatus of claim 361, wherein said modulator is configured to selectively modulate sympathetic afferent neurons.

379. The apparatus of claim 361, wherein said modulator is configured to selectively modulate sympathetic efferent neurons.

380. The apparatus of claim 361, wherein said modulator comprises a single or plurality of modulators configured to modulate multiple modalities.

381. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and sympathetic efferent neurons.

382. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastric muscle tissue.

383. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastric pylorus muscle tissue.

384. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and gastrointestinal tissue.

385. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord neurons.

386. The apparatus of claim 385, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and spinal cord neurons.

387. The apparatus of claim 385, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and spinal cord neurons.

388. The apparatus of claim 385, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord afferent neurons.

389. The apparatus of claim 385, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and spinal cord efferent neurons.

390. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and muscle tissue.

391. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and muscle tissue.

392. The apparatus of claim 391, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastric muscle tissue.

393. The apparatus of claim 391, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastric pylorus muscle tissue.

394. The apparatus of claim 391, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and gastrointestinal tissue.

395. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic neurons.

396. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and somatic afferent neurons.

397. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and somatic efferent neurons.

398. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic afferent neurons.

399. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic neurons and somatic efferent neurons.

400. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic afferent neurons and somatic neurons.

401. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and somatic neurons.

402. The apparatus of claim 380, wherein said single or plurality of modulators are configured to modulate sympathetic efferent neurons and spinal cord neurons.

403. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates sympathetic efferent neurons.

404. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates sympathetic afferent neurons.

405. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates neurons in the locus ceruleus.

406. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates intermediolateral nucleus neurons.

407. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates sympathetic trunk neurons.

408. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates splanchnic nerve neurons.

409. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates greater splanchnic nerve neurons.

410. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates lesser splanchnic nerve neurons.

411. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates thoracic splanchnic nerve neurons.

412. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates thoracic greater splanchnic nerve neurons.

413. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates thoracic lesser splanchnic nerve neurons.

414. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates abdominal splanchnic nerve neurons.

415. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates abdominal greater splanchnic nerve neurons.

416. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates abdominal lesser splanchnic nerve neurons.

417. The apparatus of claim 361, wherein said controller is configured to generate a signal which modulates a single or plurality of sympathetic neurons which further modulate activity of the locus ceruleus.

418. The apparatus of claim 361, wherein said controller is configured to generate a signal which selectively modulates sympathetic afferent neurons.

419. The apparatus of claim 361, wherein said controller is configured to generate a signal which selectively modulates sympathetic efferent neurons.

420. The apparatus of claim 361, wherein said modulator is configured to modulate sympathetic spinal neurons.

421. The apparatus of claim 361, wherein said processor is configured to generate a signal which modulates sympathetic spinal neurons.

422. The apparatus of claim 361, wherein said controller is configured to generate a single or plurality of signals which modulate multiple modalities.

423. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and sympathetic efferent neurons.

424. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastric muscle tissue.

425. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastric pylorus muscle tissue.

426. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and gastrointestinal tissue.

427. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord neurons.

428. The apparatus of claim 427, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and spinal cord neurons.

429. The apparatus of claim 427, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and spinal cord neurons.

430. The apparatus of claim 427, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord afferent neurons.

431. The apparatus of claim 427, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord efferent neurons.

432. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and muscle tissue.

433. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and muscle tissue.

434. The apparatus of claim 433, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastric muscle tissue.

435. The apparatus of claim 433, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastric pylorus muscle tissue.

436. The apparatus of claim 433, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and gastrointestinal tissue.

437. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic neurons.

438. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and somatic afferent neurons.

439. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and somatic efferent neurons.

440. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic afferent neurons.

441. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and somatic efferent neurons.

442. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic afferent neurons and somatic neurons.

443. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic efferent neurons and somatic neurons.

444. The apparatus of claim 422, wherein said controller is configured to generate a single or plurality of signals which modulate sympathetic neurons and spinal cord neurons.

445. A device for treating disease, comprising:

(A) a pulse generator, wherein pulse generator comprises a controller configured to generate a signal which modulates at least a portion of the sympathetic nervous system to induce weight loss;

(B) a connecting cable attached to said pulse generator; and

446. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises the sympathetic trunk.

447. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a splanchnic nerve.

448. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a greater splanchnic nerve.

449. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a lesser splanchnic nerve.

450. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a spinal cord.

451. The, device as in claim 445, wherein said portion of the sympathetic nervous system comprises afferents to the spinal cord.

452. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises efferents from the spinal cord.

453. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises an intermediolateral nucleus.

454. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises sympathetic neurons.

455. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a sympathetic neuron.

456. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a sympathetic axon.

457. The device as in claim 445, wherein said portion of the sympathetic nervous system comprises a sympathetic cell body.

458. The device as in claim 445, wherein said modulator is configured to interface with a portion of a sympathetic trunk.

459. The device as in claim 445, wherein said modulator is configured to interface with a portion of a splanchnic nerve.

460. The device as in claim 445, wherein said modulator is configured to interface with a portion of a greater splanchnic nerve.

461. The device as in claim 445, wherein said modulator is configured to interface with a portion of a lesser splanchnic nerve.

462. The device as in claim 445, wherein said modulator is configured to interface with a portion of a spinal cord.

463. The device as in claim 445, wherein said modulator is configured to interface with a portion of afferents to the spinal cord.

464. The device as in claim 445, wherein said modulator is configured to interface with a portion of efferents from the spinal cord.

465. The device as in claim 445, wherein said modulator is configured to interface with a portion of an intermediolateral nucleus.

466. The device as in claim 445, wherein said modulator is configured to interface with a portion of sympathetic neurons.

467. The device as in claim 445, wherein said modulator is configured to interface with a portion of a sympathetic neuron.

468. The device as in claim 445, wherein said modulator is configured to interface with a portion of a sympathetic axon.

469. The device as in claim 445, wherein said modulator is configured to interface with a portion of a sympathetic cell body.

470. The device as in claim 445, wherein said signal influences metabolic rate.

471. The device as in claim 445, wherein said signal induces an increase in metabolic rate.

472. The device as in claim 445, wherein said signal induces a decrease in metabolic rate.

473. The device as in claim 445, wherein said signal influences appetite.

474. The device as in claim 445, wherein said signal induces an increase in appetite.

475. The device as in claim 445, wherein said signal induces a decrease in appetite.

476. The device as in claim 445, wherein said signal influences satiety.

477. The device as in claim 445, wherein said signal induces an increase in satiety.

478. The device as in claim 445, wherein said signal induces a decrease in satiety.

Patent Citations (29)

Patent	Date	Inventor	Cited By
US3978865(A)	1976-09-01	Trabucco	Examiner
US4256115(A)	1981-03-01	Bilitch	Examiner
US5263480(A)	1993-11-01	Wernicke et al.	Examiner
US5282468(A)	1994-02-01	Klepinski	Examiner
US5423872(A)	1995-06-01	Cigaina	Examiner
US5458626(A)	1995-10-01	Krause	Examiner
US5700282(A)	1997-12-01	Zabara	Examiner
US5782874(A)	1998-07-01	Loos	Examiner
US5919220(A)	1999-07-01	Stieglitz et al.	Examiner
US6083249(A)	2000-07-01	Familoni	Examiner
US6141588(A)	2000-10-01	Cox et al.	Examiner
US6169924(B1)	2001-01-01	Meloy et al.	Examiner
US6178349(B1)	2001-01-01	Kieval	Examiner
US6243607(B1)	2001-06-01	Mintchev et al.	Examiner
US6246912(B1)	2001-06-01	Sluijter et al.	Examiner
US6356786(B1)	2002-03-01	Rezai et al.	Applicant
US6356787(B1)	2002-03-01	Rezai et al.	Applicant
US6438423(B1)	2002-08-01	Rezai et al.	Applicant
US6487446(B1)	2002-11-01	Hill et al.	Examiner
US6564101(B1)	2003-05-01	Zikria	Examiner
US6587719(B1)	2003-07-01	Barrett et al.	Examiner
US6591137(B1)	2003-07-01	Fischell et al.	Examiner
US6606523(B1)	2003-08-01	Jenkins	Examiner
US6895279(B2)	2005-05-01	Loeb et al.	Examiner
US2003/0027998(A1)	2003-02-01	Holtzman et al.	Examiner
US2003/0181958(A1)	2003-09-01	Dobak, III	Applicant
US2003/0181959(A1)	2003-09-01	Dobak, III	Applicant
US2006/0129201(A1)	2006-06-01	Lee et al.	Applicant
US2006/0161217(A1)	2006-07-01	Jaax et al.	Applicant

Non-Patent Literature (50)

Barone, FC, I Zarco de Coronado, MJ Wayner, Gastic distension modulates hypothalamic neurons via a sympathic affert path through the mesencephalic periaqueductal gray, Brain Research Bulletin, 1995, 38(3); pp. 239-251.Applicant
Brown, FD, RG Fessler, JR Rachlin, et al., Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs. Journal of Neurosurgery, 1984. 60(6): p. 1253-7.Applicant
Yuan, CS, WW Barber, Hypothalamic unitary responses to gastric vagal input from the proximal stomach. American Journal of Physiology, 1992. 262(1 Pt 1): p. G74-80.Applicant
Gray, H, ed. Gray's Anatomy., ed. T. Pick and R. Howden. 1974, Running Press: Philadelphia.Applicant
Takahashi, A, T Shimazu, Hypothalamic regulation of lipid metabolism in the rat: effect of hypothalamic stimulation on lipogenesis. Journal of the Autonomic Nervous System, 1982. 6(2): p. 225-35.Applicant
Ban, T, Fiber connections in the hypothalamus and some autonomic functions. Pharmacology, Biochemistry & Behavior, 1975. 3(1 Suppl): p. 3-13.Applicant
Flaim, K, B Horwitz, J Horowitz, Coupling of signals to brown fat: a- and b-adrenergic responses in intact rats. Amer. J. Physiol., 1977. 232: p. R101-R109.Applicant
Derry, D, E Schonabum, G Steiner, Two sympathetic nerve supplies to brown adipose tissue of the rat. Canad. J. Physiol. Pharmacol., 1969. 47: p. 57-63.Applicant
Daniel, H, D Derry, Criteria for differentiation of brown and white fat in the rat. Canad. J. Physiol. Pharmacol., 1969. 47: p. 941-945.Applicant
DiLorenzo, Daniel John, “Development of a Chronically Implanted Microelectrode Array for Intraneural Electrical Stimulation for Prosthetic Sensory Feedback”,MIT SM Thesis,1999.Applicant
DiLorenzo, Daniel John, “Chronic Intraneural Electrical Stimulation for Prosthetic Sensory Feedback”, Proc. 1st Intl IEEE EMBS Conf Neural Eng, Mar. 20-22, 2003.Applicant
Daniel et al., “Criteria for Differentiation of Brown and White Fat in the Rat”, Canadian Journal of Physiology and Pharmacology, vol. 47, 1969; pp. 941-945.Applicant
Zardetto-Smith et al., “Catecholamine and NPY Efferents From the Ventrolateral Medulla to the Amygdala in the Rat”,Brain Research Bulletin, vol. 38, No. 3, 1995, pp. 253-260.Applicant
Barone et al., “Gastric Distension Modulates Hypothalamic Neurons Via a Sympathetic Afferent Path Through the Mesencephalic Periaqueductal Gray”, Brain Research Bulletin, vol. 38, No. 3, 1995; pp. 239-251.Applicant
Ban, Tadayasu; “Fiber Connections in the Hypothalamus and Some Autonomic Functions”, Central Neural Control of Eating and Obesity, Pharmacology Biochemistry and Behavior, vol. 3, Suppl. 1; 1975, pp. 3-13.Applicant
Brown et al., “Changes in Food Intake with Electrical Stimulation of the Ventromedial Hypothalamus in Dogs”, Journal of Neurosurgery, vol. 60, 1984, pp. 1253-1257.Applicant
Derry et al., “Two Sympathetic Nerve Supplies to Brown Adipose Tissue of the Rat”, Canadian Journal Of Physiology and Pharmacology, vol. 47, 1969, pp. 57-63.Applicant
Flaim et al., “Coupling of Signals to Brown Fat: α-and β-Adrenergic Responses in Intact Rats”, In Vivo Adrenergic Responses of Brown Adipose Tissue, 1976, pp. R101-R109.Applicant
Takahashi et al., “Hypothalamic Regulation of Lipid Metabolism in the Rat: Effect of Hypothalamic Stimulation on Lipogenesis”, Journal of the Autonomic Nervous System, vol. 6, 1984, pp. 225-235.Applicant
Yuan et al, “Hypothalamic Unitary Responses to Gastric Vagal Input from the Proximal Stomach”, Gastric Vagal Input to Hypothalamus, 1992, pp. G74-G80.Applicant
Astrup A, Breum L, Toubro S, Hein P, Quaade F. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial. Int.J.Obes.Relat Metab Disord. (1992), pp. 269-277.Applicant
Astrup A, Buemann B, Christensen NJ, Toubro S, Thorbek G, Victor OJ, Quaade F. The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women. Metabolism (1992), pp. 686-688.Applicant
Astrup A, Toubro S, Christensen NJ, Quaade F. Pharmacology of thermogenic drugs. Am.J.Clin.Nutr. (1992), pp. 246S-248S.Applicant
Babinski M. Tumeur du corps pituitaire sans acromegalie et avec arret de developpement des organes genitaux. Rev Neurol (1900), pp. 531-533.Applicant
Berthoud HR, Niijima A, Sauter JF, Jeanrenaud B. Evidence for a role of the gastric, coeliac and hepatic branches in vagally stimulated insulin secretion in the rat. J.Auton.Nerv.Syst. (1983), pp. 97-110.Applicant
Bray GA. Obesity, a disorder of nutrient partitioning: the Mona Lisa hypothesis. J.Nutr. (1991), pp. 1146-1162.Applicant
Bray GA. Genetic, hypothalamic and endocrine features of clinical and experimental obesity. Prog.Brain Res. (1992), pp. 333-340.Applicant
Bray GA. Reciprocal relation of food intake and sympathetic activity: experimental observations and clinical implications. Int.J.Obes.Relat Metab Disord. (2000), pp. S8-17.Applicant
Bray GA, Gallagher TF, Jr. Manifestations of hypothalamic obesity in man: a comprehensive investigation of eight patients and a reveiw of the literature. Medicine (Baltimore) (1975), pp. 301-330.Applicant
Bray GA, York DA, Fisler JS. Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system. Vitam.Horm. (1989), pp. 1-125.Applicant
Bruch H. The Frohlich syndrome: report of the original case. 1939. Obes. Res. (1939), pp. 329-331.Applicant
Cigaina V, V, Saggioro A, Rigo V, V, Pinato G, Ischai S. Long-term Effects of Gastric Pacing to Reduce Feed Intake in Swine. Obes.Surg. (1996), pp. 250-253.Applicant
Dulloo AG. Ephedrine, xanthines and prostaglandin-inhibitors: actions and interactions in the stimulation of thermogenesis. Int.J.Obes.Relat Metab Disord. (1993), pp. S35-S40.Applicant
Greenway FL. The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent. Obes.Rev. (2001), pp. 199-211.Applicant
Inoue S, Bray GA. The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology (1977), pp. 108-114.Applicant
Inoue S, Bray GA, Mullen YS. Transplantation of pancreatic beta-cells prevents development of hypothalamic obesity in rats. Am.J.Physiol (1978), pp. E266-E271.Applicant
Jeanrenaud B. Energy fuel and hormonal profile in experimental obesities. Experientia Suppl (1983), pp. 57-76.Applicant
King BM, Frohman LA. The role of vagally-medicated hyperinsulinemia in hypothalamic obesity. Neurosci.Biobehav.Rev. (1982), pp. 205-214. [28] Kral JG. Vagotomy.Applicant
Niijima A, Rohner-Jeanrenaud F, Jeanrenaud B. Role of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue. Am.J.Physiol (1984), pp. R650-R654.Applicant
Pasquali R, Casimirri F, Melchionda N, Grossi G. Bortoluzzi L, Morselli Labate AM, Stefanini C, Raitano A. Effects of chronic administration of ephedrine during very-low-calorie diets on energy expenditure, protein metabolism and hormone levels in obese subjects. Clin.Sci.(Lond) (1992), pp. 85-92.Applicant
Perkins MN, Rothwell NJ, Stock MJ, Stone TW. Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature (1981), pp. 401-402.Applicant
Pories WJ, Swanson MS, MacDonald KG, Long SB, Morris PG, Brown BM, Barakat HA, deRamon RA, Israel G, Dolezal JM, . Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann.Surg. (1995), pp. 339-350.Applicant
Reeves AG, Plum F. Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. Arch.Neurol. (1969), pp. 616-624.Applicant
Sakaguchi T, Bray GA, Eddlestone G. Sympathetic activity following paraventricular or ventromedial hypothalamic lesions in rats. Brain Res.Bull. (1988), pp. 461-465.Applicant
Sauter JF, Berthoud HR, Jeanrenaud B. A simple electrode for intact nerve stimulation and/or recording in semi-chronic rats. Pflugers Arch. (1983), pp. 68-69.Applicant
Seydoux J. ssimacopoulos-Jeannet F, Jeanrenaud B, Girardier L. Alterations of brown adipose tissue in genetically obese (ob/ob) mice. I. Demonstration of loss of metabolic response to nerve stimulation and catecholamines and its partial recovery after fasting or cold adaptation. Endocrinology (1982), pp. 432-438.Applicant
Shimizu H, Shargill NS, Bray GA. Adrenalectomy and response to corticosterone and MSH in the genetically obese yellow mouse. Am.J.Physiol (1989), pp. R494-R500. [38] Smith DK, Sarfeh J, Howard L. Truncal vagotomy.Applicant
Tokunaga K, Fukushima M, Kemnitz JW, Bray GA. Effect of vagotomy on serum insulin in rats with paraventricular or ventromedial hypothalamic lesions. Endocrinology (1986), pp. 1708-1711. [40 ] Vander Tuig JG, Knehans AW, Romsos DR. Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions. Life Sci. (1982), pp. 913-920.Applicant
York DA, Bray GA. Dependence of hypothalamic obesity on insulin, the pituitary and the adrenal gland. Endocrinology (1972), pp. 885-894.Applicant
Yoshida T, Bray GA. Catecholamine turnover in rats with ventromedial hypothalamic lesions. Am.J.Physiol (1984), pp. R558-R565.Applicant

Abstract