Method of identifying inhibitors of DHODH

[0001] The present invention relates to a polypeptide which comprises the ligand binding domain of human dihydroorotate dehydrogenase (DHODH), the crystalline forms of this polypeptide complexed with new antiproliferative agents and the use of these crystalline forms to determine the three dimensional structure of the ubiquinone binding site of DHODH complexed with the ligands. The invention also refers to the use of the three dimensional structure of the ubiquinone binding site of DHODH in methods of designing and/or identifying potential inhibitors of dihydroorotate dehydrogenase (DHODH), for example, compounds which are inhibitors of the ubiquinone binding site, for example, compounds which inhibit the binding of a native substrate to the ubiquinone binding site of DHODH.

[0002] Inhibitors of DHODH, an enzyme of the pyrimidine biosynthesis, and pharmaceutical compositions containing them, are useful, for example, for the treatment of rheumatoid arthritis (RA). Its treatment with usual medications as for example non-steroid anti-inflammatory agents is not satisfactory. In view of the increasing ageing of the population, especially in the developed Western countries or in Japan, the development of new medications for the treatment of RA is urgently required.

[0003] The DHODH inhibiting leflunomide (ARAVA) [EP 780128, WO 97/34600] is the first medicament of this class of compounds (leflunomides) for the treatment of RA. Leflunomide has immunomodulatorial as well as anti-inflammatorial properties [EP 217206, DE 2524929].

[0004] In the body, DHODH catalyzes the synthesis of pyrimidines, which are necessary for cell growth. An inhibition of DHODH inhibits the growth of (pathologically) fast proliferating cells, whereas cells which grow at normal speed may obtain their required pyrimidine bases from the normal metabolic cycle. The most important types of cells for the immune response, the lymphocytes, use exclusively the synthesis of pyrimidines for their growth and react particularly sensitively to DHODH inhibition. Substances that inhibit the growth of lymphocytes are important medicaments for the treatment of auto-immune diseases.

[0005] WO 99/45926 is a further reference that discloses compounds which act as inhibitors of DHODH. A further object of the present invention is to provide alternative effective agents which can be used for the treatment of diseases which require the inhibition of DHODH.

[0006] In Structure, 2000, Vol. 8, No. 1, pages 25-33, the structure of human DHODH in complex with the antiproliferative agents brequinar and leflunomide are described.

[0007] In Structure, 2000, Vol. 8, No. 1, pages 1227-1238, crystal structures of DHODH B and its product complex are determined. In Pharmaceutical Reasearch, 1998, Vol. 15, No. 2, pages 286-295, and in Biochemical Pharmacology, 1990, Vol. 40, No. 4, pages 709-714, the structure-activity relationship of leflunomide and quinoline carboxylic acid analogues is analyzed.

[0008] In the Journal of Medicinal Chemistry, 1999, Vol. 42, pages 3308-3314, virtual combinatorial syntheses and computational screening of new potential anti-Herpes compounds are described. In Table 3 on page 3313 experimental results regarding IC₅₀ and cytotoxicity are presented for 2-(2,3-difluorophenylcarbamoyl)-1-cyclopentene-1-carboxylic acid, 2-(2,6-difluorophenylcarbamoyl)-1-cyclopentene-1-carboxylic acid and 2-(2,3,4-trifluorophenyl-carbamoyl)-1-cyclopentene-1-carboxylic acid.

[0009] In one embodiment, the present invention relates to a polypeptide comprising the ligand binding domain of human dihydroorotate dehydrogenase (DHODH), crystalline forms of this polypeptide complexed with a ligand, and the three dimensional structure of the polypeptide, including the three dimensional structure of the ubiquinone binding site of DHODH.

[0010] In another embodiment, the present invention provides a method of determining the three dimensional structure of a crystalline polypeptide comprising the ubiquinone binding site of DHODH complexed with the ligands. The method comprises the steps of (1) obtaining a crystal of the polypeptide comprising the ubiquinone binding site of DHODH complexed with a ligand; (2) obtaining x-ray diffraction data for said crystal; and (3) solving the crystal structure of said crystal by using said x-ray diffraction data and the atomic coordinates for the DHODH complex with the ligand.

[0011] The invention further relates to a method of identifying a compound which is a potential inhibitor of DHODH. The method comprises the steps of (1) obtaining a crystal of the polypeptide comprising the ubiquinone binding site of DHODH complexed with a ligand; (2) obtaining the atomic coordinates of the polypeptide in said crystal; (3) using said atomic coordinates to define the ubiquinone binding site of DHODH complexed with a ligand; and (4) identifying a compound which fits the ubiquinone binding site. The method can further include the steps of obtaining or synthesizing the compound to inhibit at least one biological activity of DHODH, such as enzymatic activity.

[0012] In another embodiment, the method of identifying a potential inhibitor of DHODH comprises the step of determining the ability of one or more functional groups and/or moieties of the compound, when present in, or bound to, the ubiquinone binding site of DHODH; to interact with one or more subsites of the ubiquinone binding site of DHODH. Generally, the ubiquinone binding site of DHODH is defined by the atomic coordinates of a polypeptide comprising the ubiquinone binding site of DHODH. If the compound is able to interact with a preselected number or set of subsites, or has a calculated interaction energy with a desired or preselected range, the compound is identified as a potential inhibitor of DHODH.

[0015] The human DHODH enzyme is composed of two domains, namely a large C-terminal domain (Met78 to C-terminus) and a small N-terminal domain (Met30 to Leu68), connected by an extended loop. The large C-terminal domain can be described best as an α/β-barrel fold with a central barrel of eight parallel β strands surrounded by eight α helices. The redox site, formed by the substrate binding site and the site of the cofactor flavine mononucleotide (FMN), is located on this large C-terminal domain. The small N-terminal domain, on the other hand, consists of two α helices, α1 and α2, connected by a short loop. This small N-terminal domain contains the binding site for the cofactor ubiquinone. The helices α1 and α2 span a slot of about 10×20 Å in the so-called hydrophobic patch, with the short α1-α2 loop at the narrow end of that slot. The slot forms the entrance to a tunnel that ends at the FMN cavity nearby the α1-α2 loop. This tunnel is narrowing towards the proximal redox site and ends with several charged or polar sidechains (Gln47, His56, Tyr356, Thr360 and Arg136). It is evident that ubiquinone which can easily diffuse into the mitochondrial inner membrane uses this tunnel to approach the FMN cofactor for a redox reaction.

[0016] The structural knowledge mentioned above can be used to design potential inhibitors of the human DHODH activity targeting the tunnel mentioned above and competing with ubiquinone for the ubiquinone binding site. Potential inhibitors were co-crystallized with human DHODH (Met30 to Arg396) and the three dimensional structures were solved by protein X-ray crystallography techniques, ten of the solved structures being three dimensional structures of human DHODH (Met30 to Arg396) in complex with compounds 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10. These crystal structures were solved at atomic resolution and the binding modes of the ten compounds were analyzed. The structural formulars of the co-crystallized compounds are given below.

[0017]

[0018] Detailed analysis of the three dimensional structure of the DHODH small N-terminal domain as well as the three dimensional structure of DHODH in complex with certain inhibitors designed to target the ubiquinone binding site revealed the presence of a number of subsites. Each subsite includes molecular functional groups or moieties capable of forming stabilizing interactions with complementary functional groups or moieties of an inhibitor.

[0019] The found subsites are characterized below according to the properties of functional groups or chemical moieties they are complementary to, or they can interact with in a stabilizing way, for example, groups or moieties capable of hydrogen bond formation or groups or moieties with hydrophobic (=lipophilic) character. A hydrogen bond is formed between a hydrogen atom covalently bond to an electronegative element (proton donor or hydrogen bond donor) and a lonely electron pair of a second electronegative atom (proton acceptor or hydrogen bond acceptor). Hydrogen bonds typically occur when the hydrogen bond donor and the hydrogen bond acceptor are separated by about 2.5 Å and 3.5 Å. Stabilizing hydrophobic or lipophilic interactions occur if two groups or moieties with hydrophobic/lipophilic character, for example, aliphatic chains or aromatic systems, are separated by distances close to their van der Waals radii.

[0020] The method of identifying a potential inhibitor of DHODH comprises the step of determining the ability of one or more functional groups and/or moieties of the compound, when present in the ubiquinone binding site, to interact with one or more subsites of the ubiquinone binding site. Preferably, the ubiquinone binding site is defined by the atomic coordinates of a polypeptide comprising the ubiquinone binding site of DHODH. If the compound is able to interact with a preselected number or set of subsites, the compound is identified as a potential inhibitor of DHODH.

[0021] A functional group or moiety of the compound is said to “interact” with a subsite of the ubiquinone binding site if it participates in an energetically favourable, or stabilizing, interaction with one or more complementary moieties within the subsite.

[0022] Two chemical moieties are “complementary” if they are capable, when suitably positioned, of participating in an attractive, or stabilizing, interaction, such as an electrostatic or an van der Waals interaction. Typically, the attractive interaction is an ion-ion, a salt bridge, ion-dipole, dipole-dipole, hydrogen bond, pi-pi or hydrophobic interaction. An extreme case of attractive interaction is the formation of a covalent bond by a chemical reaction between the test compound and the enzyme. For example, a negatively charged moiety and a positively charged moiety are complementary because, if suitably positioned, they can form a salt bridge. Likewise, a hydrogen bond donor and a hydrogen bond acceptor are complementary if suitably positioned.

[0023] Preferably, the groups capable of hydrogen bond formation (“HB”) are selected from halogen, such as fluorine, chlorine, bromine and iodine, NO₂, haloalkyl, haloalkyloxy, CN, hydroxyl, amino, hydroxylamine, hydroxamic acid, carbonyl, carbonic acid, sulfonamide, amide, sulfone, sulfonic acid, alkylthio, alkoxy, ester, hydroxyalkylamino group, and other groups including a heteroatom having at least one lone pair of electrons, such as groups containing trivalent phosphorous, di- and tetravalent sulfur, oxygen and nitrogen atoms;

[0024] Preferably, hydrophobic groups (“H”) are selected from groups, such as linear, branched or cyclic alkyl groups; linear, branched or cyclic alkenyl groups; linear, branched or cyclic alkynyl groups; aryl groups, such as mono- and polycyclic aromatic hydrocarbyl groups and mono- and polycyclic heteroaryl groups;

[0025] Preferably, negatively charged groups (“N”) are selected from groups, such as carboxylate, sulfonamide, sulfamate, boronate, vanadate, sulfonate, sulfinate and phosphonate groups. A given chemical moiety can contain one or more of these groups.

[0026] In the following a detailed description of identified subsites is provided. Residue numbering and atom labeling is identical to the numbering and labeling in Tables 29, 30, and 31.

• [0027] Subsite 1: Hydrophobic pocket; interacting chemical moieties: H;
• [0028] Residues involved: Leu 42; Met 43; Leu 46; Ala 55; Ala 59; Phe 98; Met 111; Leu 359; Pro 364;
• [0029] Non-hydrogen atoms which interact with H: Leu 42 CB, CG, CD1, CD2; Met 43 SD, CE; Leu 46 CB, CG, CD1, CD2; Ala 55 CB; Ala 59 CA, CB; Phe 98 CG, CD1, CD2, CE1, CE2; Met 111 SD, CE; Leu 359 CA, CB, CG, CD1, CD2; Pro 364 CB, CD, CG;
• [0030] Preferably for the hydrophobic interacting with subsite 1, the group is selected from aryl groups, such as an aromatic group having five to fifteen carbon atoms, which can optionally be substituted by one or more substituents R′. More preferably the aryl group is a phenyl group, such as —CH₂Ph, —C₂H₄Ph, —CH═CH-Ph, —C≡C-Ph, -o-C₆H₄—R′, -m-C₆H₄—R′, —p—C₆H₄—R′, -o-CH₂—C₆H₄—R′, -m-CH₂—C₆H₄—R′, -p-CH₂—C₆H₄—R′; or a biphenyl group, in which the phenyl rings can optionally be substituted by one or more substituents R′, such biphenyl groups are —C₆H₄—C₆H₅; —C₆H₄—C₆H₄—R′; —C₆H₃—R′—C₆H₅; —C₆H₃—R′—C₆H₄—R′;
• [0031] —C₆H₃—R′—C₆H₄—R′; —C₆H₄—O—C₆H₅; —C₆H₃—R′—O—C₆H₄—R′; —C₆H₄—O—C₆H₄—R′; —C₆H₃—R′—O—C₆H₅; —C₆H₄—O—CH₂—C₆H₅; —C₆H₃—R′—O—CH₂—C₆H₄—R′; —C₆H₄—O—CH₂—C₆H₄—R′; —C₆H₃—R′—O—CH₂—C₆H₅;
• [0032] R′ is independently H, —CO₂R″, —CONHR″, —CR″O, —SO₂NR″, —NR″—CO-haloalkyl, —NO₂, —NR″—SO₂-haloalkyl, —NR″—SO₂-alkyl, —SO₂-alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkyloxy, aryl, arylalkyl or heteroaryl;
• [0033] R″ is independently hydrogen, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl;
• [0034] R′ is preferably F, Cl, Br, I, CF₃, OCF₃, or OCH₃;
• [0035] Subsite 2: First anion binding site; interacting with HB, N, HB and N, HB and HB, or N and N;
• [0036] Residues involved: Gln 47; Arg 136; one conserved water molecule
• [0037] Non-hydrogen atoms which interact with HB and N: Glu 47 OE1, NE2; Arg 136 NE, NH1, NH2; conserved water molecule OH2.
• [0038] preferably for one or two hydrogen bond formations with subsite 2 the group is selected from halogen, such as fluorine, chlorine, bromine and iodine, NO₂, haloalkyl, haloalkyloxy, CN, hydroxyl, amino, hydroxylamine, hydroxamic acids, carbonyl, carbonic acid, sulfonamide, amide, sulfone, sulfonic acid, alkylthio, alkoxy, such as methoxy, ester, hydroxyalkylamino, carboxylate, tetrazole, sulfonamide, sulfamate, boronate, vanadate, sulfonate, sulfinate and phosphonate group, more preferably from a carboxylate, sulfonamide, sulfamate, sulfonate, carbonyl or carbonic acid group.
• [0039] Subsite 3: Second anion binding site; interacting with HB, N, HB and N, HB and HB, or N and N;
• [0040] Residues involved: His 56; Tyr 356; Tyr 147 (interacting via a conserved water molecule);
• [0041] Non-hydrogen atoms which interact with HB and N: His 56 N, ND1; Tyr 356 OH; Tyr 147 OH (interacting via a conserved water molecule);
• [0042] preferably for one or two hydrogen bond formations with subsite 2 the group is selected from halogen, such as fluorine, chlorine, bromine and iodine, NO₂, haloalkyl, haloalkyloxy, CN, hydroxyl, amino, hydroxylamine, hydroxamic acids, carbonyl, carbonic acid, sulfonamide, amide, sulfone, sulfonic acid, alkylthio, alkoxy, such as methoxy, ester, hydroxyalkylamino, carboxylate, tetrazole, sulfonamide, sulfamate, boronate, vanadate, sulfonate, sulfinate and phosphonate group, more preferably from a carboxylate, sulfonamide, sulfamate, sulfonate, carbonyl or carbonic acid group.
• [0043] Subsite 4: Remote hydrophobic pocket; interacting chemical moieties: H;
• [0044] Residues involved: Pro 52; Val 134; Arg 136; Val 143; Thr 360; FMN;
• [0045] Non-hydrogen atoms which interact with H: Pro 52 CB, CG, CD; Val 134 CB, CG1, CG2; Val 143 CB, CG1, CG2; Thr 360 CG2; FMN C7M, C8M;
• [0046] Preferably for the hydrophobic interacting with subsite 4, the group is selected from such as linear, branched or cyclic C₁-C₆-alkyl groups; such as methyl, ethyl, propyl, butyl, tert. butyl, linear, branched or cyclic C₁-C₆-alkenyl groups; linear, branched or cyclic C₁-C₆-alkynyl groups; aryl groups, such as mono- and bi aromatic hydrocarbyl groups, such as —CH₂Ph, —C₂H₄Ph, —CH═CH-Ph, —C≡C-Ph, -o-C₆H₄—R′, -m-C₆H₄—R, —p—C₆H₄—R, -o-CH₂—C₆H₄—R, -m-CH₂—C₆H₄—R, -p-CH₂—C₆H₄—R and mono- and bicyclic heteroaryl groups, such as thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,2,5-oxadiazol-4-yl, 1,2,5-thiadiazol-3-yl, 1-imidazolyl, 2-imidazolyl, 1,2,5-thiadiazol-4-yl, 4-imidazolyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrazinyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, indolyl, indolinyl, tetrazolyl, benzo-[b]-furanyl, benzo[b]thiophenyl, benzimidazolyl, benzothiazolyl, quinazolinyl, quinoxazolinyl, or preferably isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl; all this groups can optionally be substituted by one or more substituents R, such as H, amino, alkoxy, OH, SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy hydroxyalkylamino, halogen; R is preferably F, Cl, Br, I, CF₃, OCF₃, or OCH₃;
• [0047] Core: chemical moiety connecting the different moieties interacting with Subsite 1, Subsite 2, Subsite 3, and Subsite 4;
• [0048] Preferably, the core is selected from cyclic alkyl groups; cyclic alkenyl groups; cyclic alkynyl groups; aryl groups, such as mono- and polycyclic aromatic hydrocarbyl groups and mono- and polycyclic heteroaryl groups; more preferably it is selected from mono-, or bicyclic aromatic or non-aromatic ring systems, most preferably from 5-membered mono-, or bicyclic aromatic or non-aromatic ring systems, such as trans-cyclopentan-1,2-diyl, trans-cyclohexan-1,2-diyl, cis-cyclopentan-1,2-diyl, cis-cyclohexan-1,2-diyl, 1-cyclopenten-1,2-diyl, 2-cyclopenten-1,2-diyl, 3-cyclopenten-1,2-diyl, 4-cyclopenten-1,2-diyl, 5-cyclopenten-1,2-diyl, 1-cyclopenten-1,3-diyl, 1-cyclopenten-1,4-diyl, 1-cyclohexen-1,2-diyl, 1-cyclohepten-1,2-diyl or 1-cycloocten-1,2-diyl, 2,5-dihydrothiophene-3,4-diyl, 2,5-dihydro-furan-3,4-diyl, 2,5-dihydro-1H-pyrrole-3,4-diyl, 2,5-dihydro-1-methyl-pyrrole-3,4-diyl, 2,5-dihydro-1-ethyl-pyrrole-3,4-diyl, 2,5-dihydro-1-acetyl-pyrrole-3,4-diyl, 2,5-dihydro-1-methylsulfonyl-pyrrole-3,4-diyl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,2,5-oxadiazol-4-yl, 1,2,5-thiadiazol-3-yl, 1-imidazolyl, 2-imidazolyl, 1,2,5-thiadiazol-4-yl, 4-imidazolyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrazinyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, indolyl, indolinyl, tetrazolyl, benzo-[b]-furanyl, benzo[b]thiophenyl, benzimidazolyl, benzothiazolyl, quinazolinyl, quinoxazolinyl, or preferably quinolinyl, tetrahydro-quinolinyl, isoquinolinyl, tetrahydroisoquinolinyl or from a group comprising of:

[0049]

• [0050] Bridge: chemical moiety connecting the core with Subsite 1;
• [0051] Preferably, the bridge is selected from —NH; —O; —CO—NH; —NH—CO; —NH—CO—NH; alkyl; —O—CH₂; —CH₂—O; —O—CH₂—CH₂; —CH₂—CH₂—O; —NH—CH₂; —CH₂—NH; —NH—CH₂—CH₂; —CH₂—CH₂—NH; —CH₂—CO—NH; —CH₂—NH—CO;
• [0052] Subsite 5: Solvent anchor; interacting chemical moieties: HB
• [0053] Residues involved: Met 30; Tyr 38; Leu 67;
• [0054] Non-hydrogen atoms which interact with HB: Met 30 O, SD, CE; Tyr 38 OH, CE2, CD2; Leu 67 O;
• [0055] preferably for the hydrogen bond formation with subsite 5, the group is selected from F, Cl, Br, I, CF₃, OCF₃, or OCH₃
• [0056] Subsite 6: Solvent anchor; interacting chemical moieties: H;
• [0057] Residues involved: Leu 68;
• [0058] Non-hydrogen atoms which interact with H: Leu 68 CB, CG, CD1, CD2;
• [0059] Preferably for the hydrophobic interacting with subsite 6, the group is selected from such as linear, branched or cyclic C₁-C₆-alkyl groups; such as methyl, ethyl, propyl, butyl, tert. butyl, linear, branched or cyclic C₁-C₆-alkenyl groups; linear, branched or cyclic C₁-C₆-alkynyl groups; aryl groups, such as mono- and bi aromatic hydrocarbyl groups, such as —CH₂Ph, —C₂H₄Ph, —CH═CH-Ph, —C≡C-Ph, -o-C₆H₄—R′, -m-C₆H₄—R, -p-C₆H₄—R, -o-CH₂—C₆H₄—R, -m-CH₂—C₆H₄—R, -p-CH₂—C₆H₄—R and mono- and bicyclic heteroaryl groups.
• [0060] An alkyl group, if not stated otherwise, denotes a linear or branched C₁-C₆-alkyl, preferably a linear or branched chain of one to five carbon atoms, a linear or branched C₁-C₆-alkenyl or a linear or branched C_1-6-alkinyl group, which can optionally be substituted by one or more substituents R′, preferably by halogen;
• [0061] the C₁-C₆-alkyl, C₁-C₆-alkenyl and C_1-6-alkinyl residue may be selected from the group comprising —CH₃, —C₂H₅, —CH═CH₂, —C≡CH, —C₃H₇, —CH(CH₃)₂, —CH₂—CH═CH₂, —C(CH₃)═CH₂, —CH═CH—CH₃, —C≡C—CH₃, —CH₂—C≡CH, —C₄H₉, —CH₂—CH(CH₃)₂, —CH(CH₃)—C₂H₅, —C(CH₃)₃, —C₅H₁₁, —C₆H₁₃, —C(R′)₃, —C₂(R′)₅, —CH₂—C(R′)₃, —C₃(R′)₇, —C₂H₄—C(R′)₃, —C₂H₄—CH═CH₂, —CH═CH—C₂H₅, —CH═C(CH₃)₂, —CH₂—CH═CH—CH₃, —CH═CH—CH═CH₂, —C₂H₄—C≡CH, —C≡C₂H₅, —CH₂—C≡C—CH₃, —C≡C—CH═CH₂, —CH═CH—C≡CH, —C≡C—C≡CH, —C₂H₄—CH(CH₃)₂, —CH(CH₃)—C₃H₇, —CH₂—CH(CH₃)—C₂H₅, —CH(CH₃)—CH(CH₃)₂, —C(CH₃)₂—C₂H₅, —CH₂—C(CH₃)₃, —C₃H₆—CH═CH₂, —CH═CH—C₃H₇, —C₂H₄—CH═CH—CH₃, —CH₂—CH═CH—C₂H₅, —CH₂—CH═CH—CH═CH₂, —CH═CH—CH═CH—CH₃, —CH═CH—CH₂—CH═CH₂, —C(CH₃)═CH—CH═CH₂, —CH═C(CH₃)CH═CH₂, —CH═CH—C(CH₃)═CH₂, —CH₂—CH═C(CH₃)₂, C(CH₃)═C(CH₃)₂, —C₃H₆—C≡CH, —C≡C—C₃H₇, —C₂H₄—C≡CH₃, —CH₂—C≡C—C₂H₅, —CH₂—C≡C—CH═CH₂, —CH₂—CH═CH—C≡CH, —CH₂—C≡C—C≡CH, —C≡C—CH═CH—CH₃, —CH═CH—C≡C—CH₃, —C≡C—C≡C—CH₃, —C≡C—CH₂—CH═CH₂, —CH═CH—CH₂—C≡CH, —C≡C—CH₂—C≡CH, —C(CH₃)═CH—CH═CH₂, —CH═C(CH₃)CH═CH₂, —CH═CH—C(CH₃)═CH₂, —C(CH₃)═CH—C≡CH, —CH═C(CH₃)—C≡CH, —C≡C—C(CH₃)═CH₂, —C₃H₆—CH(CH₃)₂, —C₂H₄—CH(CH₃)—C₂H₅, —CH(CH₃)—C₄H₉, —CH₂—CH(CH₃)—C₃H₇, —CH(CH₃)—CH₂—CH(CH₃)₂, —CH(CH₃)—CH(CH₃)—C₂H₅, —CH₂—CH(CH₃)—CH(CH₃)₂, —CH₂—C(CH₃)₂—C₂H₅, —C(CH₃)₂—C₃H₇, —C(CH₃)₂—CH(CH₃)₂, —C₂H₄—C(CH₃)₃, —CH(CH₃)—C(CH₃)₃, —C₄H₈—CH═CH₂, —CH═CH—C₄H₉, —C₃H₆—CH═CH—CH₃, —CH₂—CH═CH—C₃H₇, —C₂H₄—CH═CH—C₂H₅, CH₂—C(CH₃)═C(CH₃)₂, —C₂H₄—CH═C(CH₃)₂, —C₄H₈—C≡CH, —C≡C—C₄H₉, —C₃H₆—C≡C—CH₃, —CH₂—C≡C—C₃H₇, —C₂H₄—C≡C—C₂H₅;
• [0062] R′ is independently H, —CO₂R″, —CONHR″, —CR″O, —SO₂NR″, —NR″—CO-haloalkyl, —NO₂, —NR″—SO₂-haloalkyl, —NR″—SO₂-alkyl, —SO₂-alkyl, —NR″—CO-alkyl, —CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, —OH, —SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkyloxy, aryl, arylalkyl or heteroaryl;
• [0063] R″ is independently hydrogen, haloalkyl, hydroxyalkyl, alkyl, cycloalkyl, aryl, heteroaryl or aminoalkyl;
• [0064] a cycloalkyl group denotes a non-aromatic ring system containing four to eight carbon atoms, preferably four to eight carbon atoms, wherein one or more of the carbon atoms in the ring can be substituted by a group X, X being as defined above; the C₄-C₈-cycloalkyl residue may be selected from the group comprising -cyclo-C₄H₇, -cyclo-C₅H₉, -cyclo-C₆H₁₁, -cyclo-C₇H₁₃, -cyclo-C₈H₁₅;
• [0065] an alkoxy group denotes an O-alkyl group, the alkyl group being as defined above; the alkoxy group is preferably a methoxy, ethoxy, isopropoxy, t-butoxy or pentoxy group;
• [0066] an alkylthio group denotes an S-alkyl group, the alkyl group being as defined above.
• [0067] an haloalkyl group denotes an alkyl group which is substituted by one to five halogen atoms, the alkyl group being as defined above; the haloalkyl group is preferably a —C(R¹⁰)₃, —CR¹⁰(R^10′)₂, —CR¹⁰(R^10′)R^10″, —C₂(R¹⁰)₅, —CH₂—C(R¹⁰)₃, —CH₂—CR¹⁰(R^10′)₂, —CH₂—CR¹⁰(R^10′)R^10″, —C₃(R¹⁰)₇ or —C₂H₄—C(R¹⁰)₃, wherein R¹⁰, R^10′, R^10″ represent F, Cl, Br or I, preferably F;
• [0068] a hydroxyalkyl group denotes an HO-alkyl group, the alkyl group being as defined above;
• [0069] an haloalkyloxy group denotes an alkoxy group which is substituted by one to five halogen atoms, the alkyl group being as defined above; the haloalkyloxy group is preferably a —OC(R¹⁰)₃, —OCR¹⁰(R^10′)₂, —OCR¹⁰(R^10′)R^10″, —OC₂(R¹⁰)₅, —OCH₂—C(R¹⁰)₃, —OCH₂—CR¹⁰(R^10′)₂, —OCH₂—CR¹⁰(R^10′)R^10″, —OC₃(R¹⁰)₇ or —OC₂H₄—C(R¹⁰)₃, wherein R¹⁰, R^10′, R^10″ represent F, Cl, Br or I, preferably F;
• [0070] a hydroxyalkylamino group denotes an (HO-alkyl)₂-N— group or HO-alkyl-NH— group, the alkyl group being as defined above;

[0071] an alkylamino group denotes an HN-alkyl or N-dialkyl group, the alkyl group being as defined above;

• [0072] a halogen group is chlorine, bromine, fluorine or iodine, fluorine being preferred;
• [0073] an aryl group preferably denotes an aromatic group having five to fifteen carbon atoms, which can optionally be substituted by one or more substituents R′, where R′ is as defined above; the aryl group is preferably a phenyl group, —CH₂Ph, —C₂H₄Ph, —CH═CH-Ph, —C≡C-Ph, -o-C₆H₄—R′, -m-C₆H₄—R′, -p-C₆H₄—R′, -o-CH₂—C₆H₄—R′, -m-CH₂—C₆H₄—R′, -p-CH₂—C₆H₄—R′;
• [0074] a heteroaryl group denotes a 5- or 6-membered heterocyclic group which contains at least one heteroatom like O, N, S. This heterocyclic group can be fused to another ring. For example, this group can be selected from a thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,2,5-oxadiazol-4-yl, 1,2,5-thiadiazol-3-yl, 1-imidazolyl, 2-imidazolyl, 1,2,5-thiadiazol-4-yl, 4-imidazolyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrazinyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, 1H-tetrazol-2-yl, 1H-tetrazol-3-yl, tetrazolyl, indolyl, indolinyl, benzo-[b]-furanyl, benzo[b]thiophenyl, benzimidazolyl, benzothiazolyl, quinazolinyl, quinoxazolinyl, or preferably quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl group. This heterocyclic group can optionally be substituted by one or more substituents R′, where R′ is as defined above. In another embodiment, the present invention provides DHODH inhibitors, and methods of use thereof, which are capable of binding to the ubiquinone binding site of DHODH, for example, compounds wich are identified as inhibitors of DHODH or which are designed by the methods described above to inhibit DHODH. For example, the invention includes compounds which interact with one or more, preferably two or more, and more preferably, three or more of DHODH subsites 1 to 6.

[0075] Preferably an inhibitor of DHODH should have a core-unit and interact with subsite 1, 2, 3 and 5 or an inhibitor of DHODH should have a core-unit and interact with subsite 1, 2 and 5, or an inhibitor of DHODH should have a core-unit and interact with subsite 1, 3 and 5.

[0076] More preferably an inhibitor of DHODH should have a core-unit and interact with subsite 1, 2 and 3, or an inhibitor of DHODH should have a core-unit and interact with subsite 1 and 3. In FIG. 1, the spatial arrangement of the subsites is depicted schematically.

[0077] The three dimensional structure published by Shenpig et al. shows human DHODH(Met30-Arg396) in complex with brequinar and the leflunomide metabolite A771726, respectively. The main interaction in the binding of brequinar to DHODH is the formation of a salt bridge between the carboxy group of brequinar and the sidechain of Arg136. In particular, the salt bridge is formed between the carboxylic group and the atoms NE, NH1 or NH2. More precisely, the above mentioned subsite 2, the first anion binding site, is addressed in this kind of interaction. In the following, this type of interactioned will be termed “brequinar-like binding mode”.

[0078] Analysis of the three dimensional structures of human DHODH in complex with ligands presented here clearly shows a new binding mode for inhibitors containing a carboxylic acid group. This binding mode differs from the brequinar-like binding mode in interacting not with subsite 2 but with subsite 3, termed the second anion binding site. In particular this is true for inhibitor compounds 1, 4, 5, 7 and 8 as can be seen from Table 29. This so far unobserved binding mode will be termed “non-brequinar-like” binding mode in the following.

[0079] The “non-brequinar-like” binding mode is characterized by a number of hydrogen bonds formed between the ligand and protein residues belonging to subsite 3. In particular this residues are His 56, Tyr 356 and Tyr 147. Non-hydrogen atoms involved in the formation of hydrogen bonds are N and ND1 of His 56, the oxygen of the hydroxyl group of Tyr 356 and the oxygen of the hydroxyl group of Tyr 147. The latter interaction involves a conserved water molecule bridging the space between the carboxyl function of the ligand molecule and the hydroxyl group of the tyrosine residue 147.

[0080] Similar findings can be seen in the three dimensional structure of human DHODH in complex with the compounds 2, 6 and 10. As can be seen clearly from the electron density map, the compounds 2, 6 and 10 are able to utilize both anion binding sites (subsite 2 and 3) by adopting two alternative conformations. Therefore, both a brequinar-like and a non-brequinar-like binding mode can be utilized. In the brequinar-like binding mode the carboxy group of compounds 2, 6 and 10 forms hydrogen bonds to the sidechains of residues Gln 47 and Arg 136. In the non-brequinar-like binding mode the five membered ring of compounds 2, 6 and 10 containing the carboxy group is rotated by almost 180 degrees and forms hydrogen bonds to residues His 56 and Tyr 356. Non-hydrogen atoms involved in the formation of hydrogen bonds are N and ND1 of His 56 and the oxygen of the hydroxyl group of Tyr 356.

[0081] The compounds 2, 3 and 4 are particularly interesting for a structure-activity-relationship (SAR) analysis. These molecules differ only in the degree of ring substitution (see structures above). Clearly, one can observe a correlation between the number of fluorinated positions at the aromatic ring in the middle of the molecules and the corresponding IC₅₀ values. The higher the number of ring substituents the lower the IC₅₀. Interestingly compound 2 and compound 3 display both the brequinar-like and non-brequinar-like binding mode in the crystal structure (see table 27). It is quite reasonable to speculate whether the ring substituents exhibit a steering effect on the five membered ring and by such facilitate the formation of the more favourable brequinar-like binding mode. Therefore, the presence of both binding modes might explain the increased affinity of this compounds.

[0082]

TABLE 27
Relation of inhibitor binding mode and degree of ring substitutions.
Structures of the compounds are shown above.
Compound	Brequinar-like	Non-Brequinar-like
3	X	X
2	X	X
4		X

[0083] A similar structure-activity-relationship can be deduced from the crystal structures of humann DHODH in complex with compounds 9 and 10. These compounds carry a sulfur atom at an ortho position with respect to the carboxylic group in the five membered ring. Compound 10 is single substituted with fluorine at the biaryl ring system, whereas compound 9 bears two substituents. Interestingly, compound 9 exhibits a pure brequinar-like binding mode whereas compound 10 shows both alternatives. Additionally, the sulfur atom in the ortho position on the five membered ring can favourably interact with the protein's subsite 4 (remote hydrophobic pocket). The activity data correlate to a very high degree with the presence of a particular binding mode (Table 28). Obviously, not only the degree of ring subsitution but also ring planarity might contribute to the formation of a particular binding mode.

[0084]

TABLE 28
Relation of inhibitor binding mode and degree of ring substitutions.
Structures of the compounds are shown above.
Compound	Brequinar-like	Non-Brequinar-like
9	X
10	X	X

[0085] From the discussion above several possibilities for further synthesis of compounds emerge. First, one could try to stabilize the Brequinar-like conformation by a more elaborate variation of substitution patterns at the aromatic ring system. A second way to improve on the affinity might comprise the addition of a second functional group, which is able to form hydrogen bonds or salt bridges to the five membered ring opposite to the position of the carboxy group. Thus the molecule should be able to address both anion subsites and utilize brequinar-like as well as non-brequinar-like binding modes at the same time. This is highly supported by the evidence of structural data. Mobility at the site of Gln47 and Arg136 indicates that the protein should be able to exhibit sufficient conformational flexibility to adopt ligand molecules displaying more demanding sterical requirements.

[0086] Another interesting finding is that the DHODH binding pocket is able to selectively discriminate between enantiomeres. Compounds 5 and 6 were synthesized as a racemic mixtures caused by the presence of a stereo centre at the five membered ring (see above). The racemic mixtures were used for crystallization experiments. In both cases the refined structures unequivocally showed the inhibitor bound in its R-form. It is not possible to fit the S-enantiomer into the electron density.

[0087] The invention further provides a method of designing a compound which is a potential inhibitor of DHODH. The method includes the steps of (1) identifying one or more functional groups capable of interacting with one or more subsites of the ubiquinone binding site of DHODH; and (2) identifying a scaffold which presents the functional group or functional groups identified in step 1 in a suitable orientation for interacting with one or more subsites of the ubiquinone binding site of DHODH. The compound which results from attachment of the identified functional groups or moieties to the identified scaffold is a potential inhibitor of DHODH. The DHODH ubiquinone binding site is, generally, defined by the atomic coordinates of a polypeptide comprising the DHODH ubiquinone binding site.

[0088] The present invention also provides several advantages. For example, the invention provides a new three dimensional structure of a crystalline polypeptide comprising the ubiquinone binding site of DHODH complexed with the ligands. This structure enables the rational development of inhibitors of DHODH by permitting the design and/or identification of molecular structures having features which facilitate binding to the ubiquinone binding site of DHODH. The methods of use of this structure disclosed herein, thus, permit more rapid discovery of compounds which are potentially useful for the treatment of conditions which are mediated, at least in part, by DHODH activity.

[0089] The polypeptide preferably comprises the ubiquinone binding site of a mammalian DHODH. More preferably the polypeptide comprises the ubiquinone binding site of human DHODH. In a preferred embodiment, the polypeptide is a polypeptide of the present invention, as described above.

[0090] The polypeptide can be crystallized using methods known in the art, such as the methods described in Structure, 2000, Vol. 8, No. 1, pages 25-33, to afford polypeptide crystals which are suitable for x-ray diffraction studies. A crystalline polypeptide/ligand complex can be produced by co-crystallizing the polypeptide with a solution including the ligand.

[0091] The atomic coordinates of the polypeptide and the ligand can be determined, for example, by x-ray crystallography using methods known in the art. The data obtained from the crystallography can be used to generate atomic coordinates, for example, of the polypeptide and ligand, if present. As is known in the art, solution and refinement of the x-ray crystal structure can result in the determination of coordinates for some or all of the non-hydrogen atoms.

[0092] The atomic coordinates of the polypeptide can be used, as is known in the art, to generate a three-dimensional structure of the ubiquinone binding site of DHODH. This structure can then be used to assess the ability of any given compound, preferably using computer-based methods, to fit into the ubiquinone binding site.

[0093] The atomic coordinates of the polypeptide/ligand complex can be used, as is known in the art, to generate a three-dimensional structure of the ligand in its binding conformation. This structure can then be used to assess the ability of any given compound, preferably using computer-based methods, to exhibit a similar spatial orientation and electrostatic and/or van der Waals interactions as the ligand and therefore, to fit into the addressed binding site.

[0094] A compound fits into the ubiquinone binding site if it is of suitable size and shape to physically reside in the ubiquinone binding site, that is if it has a shape which is complementary to the ubiquinone binding site and can reside in the ubiquinone binding site without significant unfavorable sterical or van der Waals interactions. Preferably, the compound includes one or more functional groups and/or moieties which interact with one or more subsites within the ubiquinone binding site. Computational methods for evaluating the ability of a compound to fit into the ubiquinone binding site, as defined by the atomic coordinates of the polypeptide, are known in the art, and representative examples are provided below.

[0095] In another embodiment, the method of identifying a potential inhibitor of DHODH comprises the step of determining the ability of one or more functional groups and/or moieties of the compound, when present in the DHODH ubiquinone binding site, to interact with one or more subsites of the DHODH ubiquinone binding site. Preferably, the DHODH ubiquinone binding site is defined by the atomic coordinates of a polypeptide comprising the DHODH ubiquinone binding site. If the compound is able to interact with a preselected number of subsites, the compound is identified as a potential inhibitor of DHODH.

[0096] In yet another embodiment, the method of identifying a potential inhibitor of DHODH comprises the steps of (1) identifying the size and shape of the ligand co-crystallized in the polypeptide/ligand complex and/or identifying functional groups or moieties of the ligand which are capable to form stabilizing interactions with the polypeptide, and (2) by comparison with these, identifying one or more functional groups and/or moieties of any given compound which have similar size and shape as the cocrystallized ligand and/or are capable to form one or more interactions to the polypeptide in a similar manner as the co-crystallized ligand. If a compound exhibits one or more of these features, the compound is identified as a potential inhibitor of DHODH.

[0097] A functional group or moiety of the compound is said to “interact” with a subsite of the DHODH ubiquinone binding site if it participates in an energetically favourable, or stabilizing, interaction with one or more complementary moieties within the subsite, as defined above.

[0098] A functional group or moiety of the compound is said to interact in a “similar” manner as the co-crystallized ligand if one or more, preferably two or more of its functional groups or moieties capable of forming the attractive interactions mentioned above can be superimposed on those functional groups or moieties of the co-crystallized ligand capable of forming the attractive interactions. The superposition can be performed based on the identity of atoms, and/or the identity or similarity of functional groups, and/or the similarity of molecular shape and/or the identity or similarity of interaction possibilities. For example, an —OH group of a compound and an —NH group of the cocrystallized ligand may interact in the same way, namely as hydrogen bond donors, with a hydrogen bond acceptor atom suitably positioned in the enzyme. Therefore, the —OH group and the —NH group are said to have similar interaction properties, and a molecule containing an —OH group may be superimposed onto a molecule carrying an —NH group at the corresponding position.

[0099] Typically, the assessment of interactions between (1) the test compound and the DHODH ubiquinone binding site and (2) the superposition of a test compound and the co-crystallized ligand employ computer-based computational methods, such as those known in the art, in which, for the first case, possible interactions of a compound with the protein, as defined by atomic coordinates, are evaluated with respect to interaction strength by calculating the interaction energy upon binding the compound to the protein. For the second case, the superposition of a test compound and the cocrystallized ligand is performed according to the identity of atoms, and/or the identity or similarity of functional groups, and/or the similarity of molecular shape and/or the identity or similarity of interaction possibilities in a process termed alignment. Matching atoms/functional groups/shape/interaction possibilities are evaluated and summarized to an alignment score enabling the ranking of the tested molecules.

[0100] Compounds which have calculated interaction energies within a preselected range or which otherwise, in the opinion of the computational chemist employing the method, have the greatest potential as DHODH inhibitors, can then be provided, for example, from a compound library or via synthesis, and assayed for the ability to inhibit DHODH. The interaction energy for a given compound generally depends upon the ability of the compound to interact with one or more subsites within the protein catalytic domain.

[0101] In one embodiment, the atomic coordinates used in the method are the atomic coordinates set forth in Tables 29, 30, and 31. It is to be understood that the coordinates set forth in Tables 29, 30, and 31 can be transformed, for example, into a different coordinate system, in ways known to those of skill in the art without substantially changing the three dimensional structure represented thereby.

[0102] In certain cases a moiety of the compound can interact with a subsite via two or more individual interactions. A moiety of the compound and a subsite can interact if they have complementary properties and are positioned in sufficient proximity and in a suitable orientation for a stabilizing interaction to occur. The possible range of distances for the moiety of the compound and the subsite depends upon the distance dependence of the interaction, as known in the art. For example, a hydrogen bond typically occurs when a hydrogen bond donor atom, which bears a hydrogen atom, and a hydrogen bond acceptor atom are separated by about 2.5 Å and about 3.5 Å. Hydrogen bonds are well known in the art. Generally, the overall interaction, or binding, between the compound and the ubiquinone binding site will depend upon the number and strength of these individual interactions.

[0103] The ability of a test compound to interact with one or more subsites of the ubiquinone binding site can be determined by computationally evaluating interactions between functional groups, or moieties, of the test compound and one or more amino acid side chains and/or backbone atoms in the ubiquinone binding site. Typically, a compound which is capable of participating in stabilizing interactions with a preselected number of subsites, preferably without simultaneously participating in significant destabilizing interactions, is identified as a potential inhibitor of DHODH. Such a compound will interact with one or more subsites, preferably with two or more subsites and, more preferably, with three or more subsites.

[0104] The invention further provides methods of designing a compound which is a potential inhibitor of DHODH.

[0105] The first method includes the steps of (1) identifying one or more functional groups capable of interacting with one or more subsites of the DHODH ubiquinone binding site; and (2) identifying a scaffold which presents the functional group or functional groups identified in step 1 in a suitable orientation for interacting with one or more subsites of the DHODH ubiquinone binding site. The compound which results from attachment of the identified functional groups or moieties to the identified scaffold is a potential inhibitor of DHODH. The DHODH ubiquinone binding site is, generally, defined by the atomic coordinates of a polypeptide comprising the DHODH ubiquinone binding site, for example, the atomic coordinates set forth in Tables 29, 30, and 31.

[0106] The second method comprises the steps of (1) identifying one or more functional groups or moieties capable of interacting in a similar way as one or more functional groups or moieties of the co-crystallized ligand, and (2) identifying a scaffold which presents the functional group or functional groups identified in step 1 in a suitable orientation for interacting in a similar way as one or more functional groups or moieties of the co-crystallized ligand. The compound which results from attachment of the identified functional groups or moieties to the identified scaffold is a potential inhibitor of DHODH. The co-crystallized ligand is, generally, defined by the atomic coordinates of a ligand complexed in the polypeptide comprising the DHODH ubiquinone binding site, for example, the atomic coordinates set forth in Tables 29, 30, and 31.

[0107] Suitable methods, as known in the art, can be used to identify chemical moieties, fragments or functional groups which are capable of interacting favorably with a particular subsite or sets of subsites. These methods include, but are not limited to: interactive molecular graphics; molecular mechanics; conformational analysis; energy evaluation; docking; database searching; virtual high-throughput screening (U.S. Pat. No. 422,303, DE 10009479, EP 1094415, U.S. Pat. Nos. 693,731, 885,893, 885,517); structural alignment; functional group alignment; interaction-point alignment; pharmacophore modeling; de novo design; property estimation and descriptor-based database searching. These methods can also be employed to assemble chemical moieties, fragments or functional groups into a single inhibitor molecule. These same methods can also be used to determine whether a given chemical moiety, fragment or functional group is able to interact favorably with a particular subsite or sets of subsites.

[0108] In one embodiment, the design of potential DHODH inhibitors begins from the general perspective of three-dimensional shape and electrostatic complementarity for the ubiquinone binding site, and subsequently, interactive molecular modeling techniques can be applied by one skilled in the art to visually inspect the quality of the fit of a candidate molecule into the binding site. Suitable visualization programs include SYBYL (Tripos Inc., St. Louis, Mo.), MOLOC (Gerber Molecular Design, Basel), RASMOL (Sayle et al. Trends Biochem. Sci. 20:374-376 (1995)) and MOE (Chemical Computing Group Inc., Montreal).

[0109] A further embodiment of the present invention utilizes a database searching program which is capable of scanning a database of small molecules of known three-dimensional structure for candidates which fit into the target protein site. Suitable software programs include 4SCan® (U.S. Pat. No. 422,303, DE 10009479, EP 1094415, U.S. Pat. Nos. 693,731, 885,893, 885,517), FLEXX (Rarey et al., J. Mol. Biol. 261:470-489 (1996)), and UNITY (Tripos Inc., St. Louis, Mo.). Especially 4SCan® was developed to scan/screen large virtual databases up to several millions of small molecules in a reasonable time-frame.

[0110] A further embodiment of the present invention utilizes a database searching program which is capable of scanning a database of small molecules of known three-dimensional structure for candidates which align properly with the co-crystallized ligand, both in shape and interaction properties. Suitable software programs include 4SCan® (U.S. Pat. No. 422,303, DE 10009479, EP 1094415, U.S. Pat. Nos. 693,731, 885,893, 885,517) and FLEXS (Lemmen et al., J. Med. Chem 41:4502-4520 (1998)). Especially 4SCan® is capable of aligning large virtual databases up to several millions of small molecules in a reasonable time-frame.

[0111] It is not expected that the molecules found in the search will necessarily be leads themselves, since a complete evaluation of all interactions will necessarily be made during the initial search. Rather, it is anticipated that such candidates might act as the framework for further design, providing molecular skeletons to which appropriate atomic replacements can be made. Of course, the chemical complementarity of these molecules can be evaluated, but it is expected that the scaffold, functional groups, linkers and/or monomers may be changed to maximize the electrostatic, hydrogen bonding, and hydrophobic interactions with the enzyme.

[0112] Goodford (Goodford J. Med. Chem. 28:849-857 (1985)) has produced a computer program, GRID, which seeks to determine regions of high affinity for different chemical groups (termed probes) on the molecular surface of the binding site. GRID hence provides a tool for suggesting modifications to known ligands that might enhance binding.

[0113] Consequently, virtual combinatorial libraries covering numerous variations of the addressed scaffold, functional groups, linkers and/or monomers can be build up using suitable software programs including LEGION (Tripos Inc., St. Louis, Mo.) or ACCORD FOR EXCEL (Accelrys Inc., San Diego, Calif.), followed by scanning or virtual screening or docking of these libraries using suitable software mentioned above.

[0114] A range of factors, including electrostatic interactions, hydrogen bonding, hydrophobic interactions, desolvation effects, conformational strain, ligand flexibility and cooperative motions of ligand and enzyme, all influence the binding effect and should be taken into account in attempts to design bioactive inhibitors.

[0115] Yet another embodiment of a computer-assisted molecular design method for identifying inhibitors of DHODH comprises searching for fragments which fit into a binding region subsite and link to a pre-defined scaffold. The scaffold itself may be identified in such a manner. A representative program suitable for the searching of such functional groups and monomers include LUDI (Boehm, J. Comp. Aid. Mol. Des. 6:61-78 (1992)) and MCSS (Miranker et al., Proteins 11: 314-328 (1991)).

[0116] Yet another embodiment of a computer-assisted molecular design method for identifying inhibitors of DHODH comprises the de novo synthesis of potential inhibitors by algorithmic connection of small molecular fragments that will exhibit the desired structural and electrostatic complementarity with the active site of the enzyme. The methodology employs a large template set of small molecules which are iteratively pierced together in a model of the DHODH ubiquinone binding site. Programs suitable for this task include GROW (Moon et al. Proteins 11:314-328 (1991)) and SPROUT (Gillet et al. J. Comp. Aid. Mol. Des. 7:127 (1993)).

[0117] In yet another embodiment, the suitability of inhibitor candidates can be determined using an empirical scoring function, which can rank the binding affinities for a set of inhibitors. For examples of such a method see Muegge et al. and references therein (Muegge et al., J. Med. Chem. 42:791-804 (1999)) and ScoreDock (Tao et al. J. Comp. Aid. Mol. Des. 15: 429-446 (2001)).

[0118] Other modeling techniques can be used in accordance with this invention, for example, those described by Stahl (Stahl, in: Virtual Screening for Bioactive Molecules, Wiley-VCH, Weinheim, 2000, pp. 229-264), Cohen et al. (J. Med. Chem. 33:883-894 (1990)); Navia et al. (Current Opinions in Structural Biology 2 :202-210 (1992)); Baldwin et al. (J. Med. Chem. 32:2510-2513 (1989)); Appelt et al. (J. Med. Chem. 34:1925-1934 (1991)); Ealick et al. (Proc. Nat. Acad. Sci. USA 88:11540-11544 (1991));

[0119] A compound which is identified by one of the foregoing methods as a potential inhibitor of DHODH can then be obtained, for example, by synthesis or from a compound library, and assessed for the ability to inhibit DHODH in vitro. Such an in vitro assay can be performed as is known in the art, for example, by contacting DHODH in solution with the test compound in the presence of the substrate and cofactor of DHODH and ubiquinone. The rate of substrate transformation can be determined in the presence of the test compound and compared with the rate in the absence of the test compound. Suitable assays for DHODH biological activity are described below, the teachings of each of which are hereby incorporated by reference herein in their entity.

[0120] An inhibitor identified or designed by a method of the present invention can be a competitive inhibitor, an uncompetitive inhibitor or a noncompetitive inhibitor with respect to ubiquinone.

[0121] A screen of thousands of compounds using 4Scan® as described above was performed. Hits were ranked according to consensus score.

[0122] In table 25 the structures of the highest ranking compounds of the combinatorial library are shown. The consensus score of each molecule is calculated by the summation of the two predicted 4SCan® activity scores for the two different structures of the ubiquinone binding site.

[0123] The compounds of the present invention can be used for a variety of human and animal diseases, preferably human diseases, where inhibition of the pyrimidine metabolism is beneficial. Such diseases are:

• • [0124] fibrosis, uveitis, rhinitis, asthma or arthropathy, in particular, arthrosis
  • [0125] all forms of rheumatism
  • [0126] acute immunological events and disorders such as sepsis, septic shock, endotoxic shock, Gram-negative sepsis, toxic shock syndrome, acute respiratory distress syndrome, stroke, reperfusion injury, CNS injury, serious forms of allergy, graft versus host and host versus graft reactions, alzheimer's disease or pyresis, restenosis, chronic pulmonary inflammatory disease, silicosis, pulmonary sarcosis, bone resorption disease. These immunological events also include a desired modulation and suppression of the immune system;
  • [0127] all types of autoimmune diseases, in particular rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis, multiple sclerosis, insulin dependent diabetes mellitus and non-insulin dependent diabetes mellitus, and lupus erythematoidis, ulcerative colitis, Morbus Crohn, inflammatory bowel disease, as well as other chronic inflammations, chronic diarrhea;
  • [0128] dermatological disorders such as psoriasis
  • [0129] progressive retinal atrophy
  • [0130] all kinds of infections including opportunistic infections.

[0131] The compounds according to the invention and medicaments prepared therewith are generally useful for the treatment of cell proliferation disorders, for the treatment or prophylaxis, immunological diseases and conditions (as for instance inflammatory diseases, neuroimmunological diseases, autoimmune diseases or other).

[0132] The compounds of the present invention are also useful for the development of immunomodulatory and anti-inflammatory medicaments or, more generally, for the treatment of diseases where the inhibition of the pyrimidine biosynthesis is beneficial.

[0133] The compounds of the present invention are also useful for the treatment of diseases which are caused by malignant cell proliferation, such as all forms of hematological and solid cancer. Therefore the compounds according to the invention and medicaments prepared therewith are generally useful for regulating cell activation, cell proliferation, cell survival, cell differentiation, cell cycle, cell maturation and cell death or to induce systemic changes in metabolism such as changes in sugar, lipid or protein metabolism. They can also be used to support cell generation poiesis, including blood cell growth and generation (prohematopoietic effect) after depletion or destruction of cells, as caused by, for example, toxic agents, radiation, immunotherapy, growth defects, malnutrition, malabsorption, immune dysregulation, anemia and the like or to provide a therapeutic control of tissue generation and degradation, and therapeutic modification of cell and tissue maintenance and blood cell homeostasis.

[0134] These diseases and conditions include but are not limited to cancer as hematological (e.g. leukemia, lymphoma, myeloma) or solid tumors (for example breast, prostate, liver, bladder, lung, esophageal, stomach, colorectal, genitourinary, gastrointestinal, skin, pancreatic, brain, uterine, colon, head and neck, ovarian, melanoma, astrocytoma, small cell lung cancer, glioma, basal and squameous cell carcinoma, sarcomas as Kaposi's sarcoma and osteosarcoma), treatment of disorders involving T-cells such as aplastic anemia and DiGeorge syndrome, Graves' disease.

[0135] Leflunomide was previously found to inhibit HCMV replication in cell culture. Ocular herpes is the most common cause of infectious blindness in the developed world. There are about 50,000 cases per year in the US alone, of which 90% are recurrences of initial infections. Recurrences are treated with antivirals and corticosteroids. Cytomegalovirus, another herpes virus, is a common cause of retinal damage and blindness in patients with aids. The compounds of the present invention can be used alone or in combination with other antiviral compounds such as ganciclovir and foscarnet to treat such diseases.

[0136] The compounds of the present invention can further be used for diseases that are caused by protozoal infestations in humans and animals. Such veterinary and human pathogenic protozoas are preferably intracellular active parasites of the phylum Apicomplexa or Sarcomastigophora, especially Trypanosoma, Plasmodia, Leishmania, Babesia and Theileria, Cryptosporidia, Sacrocystida, Amoebia, Coccidia and Trichomonadia. These active substances or corresponding drugs are especially suitable for the treatment of Malaria tropica, caused by Plasmodium falciparum, Malaria tertiana, caused by Plasmodium vivax or Plasmodium ovale and for the treatment of Malaria quartana, caused by Plasmodium malariae. They are also suitable for the treatment of Toxoplasmosis, caused by Toxoplasma gondii, Coccidiosis, caused for instance by Isospora belli, intestinal Sarcosporidiosis, caused by Sarcocystis suihominis, dysentery caused by Entamoeba histolytica, Cryptosporidiosis, caused by Cryptosporidium parvum, Chargas' disease, caused by Trypanosoma cruzi, sleeping sickness, caused by Trypanosoma brucei rhodesiense or gambiense, the cutaneous and visceral as well as other forms of Leishmaniosis. They are also suitable for the treatment of animals infected by veterinary pathogenic protozoa, like Theileria parva, the pathogen causing bovine East coast fever, Trypanosoma congolense congolense or Trypanosoma vivax vivax, Trypanosoma brucei brucei, pathogens causing Nagana cattle disease in Africa, Trypanosoma brucei evansi causing Surra, Babesia bigemina, the pathogen causing Texas fever in cattle and buffalos, Babesia bovis, the pathogen causing european bovine Babesiosis as well as Babesiosis in dogs, cats and sheep, Sarcocystis ovicanis and ovifelis pathogens causing Sarcocystiosis in sheep, cattle and pigs, Cryptosporidia, pathogens causing Cryptosporidioses in cattle and birds, Eimeria and Isospora species, pathogens causing Coccidiosis in rabbits, cattle, sheep, goats, pigs and birds, especially in chickens and turkeys. The use of the compounds of the present invention is preferred in particular for the treatment of Coccidiosis or Malaria infections, or for the preparation of a drug or feed stuff for the treatment of these diseases. This treatment can be prophylactic or curative. In the treatment of malaria, the compounds of the present invention may be combined with other anti-malaria agents.

[0137] The compounds of the present invention can further be used for viral infections or other infections caused for instance by Pneumocystis carinii.

1. X-Ray Structure Determination

Expression and Purification

[0138] The cDNA encoding for an N-terminally truncated human DHODH(Met30-Arg396) was amplified by the polymerase chain reaction (PCR) from a human liver cDNA bank (Invitrogen, Groningen). The following primers were used to amplify the DHODH gene form the cDNA bank:

[0139]

DHODH-V:
5′-GGA ATT CCA TAT GGC CAC GGG AGA	(SEQ ID NO:1)
TGA GCG-3′
DHODH-R:
5′-GCG CGG ATC CTC ACC TCC GAT GAT	(SEQ ID NO:2)
CTG C-3′

[0140] The underlined sequence regions encode for the cutting sites of the restriction enzymes NdeI (DHODH-V) and BamHI (DHODH-R), respectively. The primers are designed such that subcloning using the NdeI and BamHI restriction sites into a pET-19b vector is possible. The amplified DNA bands were purified and isolated from an agarose gel (QIAquick PCR purification kit). The band showed the expected length of 1.2 kb. The isolated PCR fragment was subcloned into a TOPO vector (Invitrogen, Groningen) according to the protocol outlined in the TOPT TA Cloning Kit. The TOPO vector including the ligated PCR fragment was digested with the restriction enzymes NdeI and BamHI (New England Biolabs Inc.) to produce sticky ends. Finally, the fragment was cloned into the NdeI/BamHI sites of a pET-19b vector (Novagen, Madison, Wis.). This vector produced the human DHODH(Met30-Arg396) as an N-terminal ten histidine fusion protein (his10-hDHODH(Met30-Arg396)). The vector was transformed into chemical competent E. coli BL21(DE3)Gold cells (Stratagene, LaJolla, Calif.). Cells were stored as glycerol stocks at −80° C. until further use.

[0141] 100 ml LB-medium in 250 ml flasks containing 100 μL freshly prepared ampicilline were inoculated with BL21(DE3)Gold cells hosting the pET-19b/hDHODH(Met30-Arg396) construct. Cells were grown overnight at 25° C. and constantly vortexed with 150 rpm.

[0142] For the expression cultures four 2 L flasks each were filled with 800 mL rich medium (LB) containing 800 μL ampicilline. The flasks were inoculated with 40 mL of overnight culture and were grown to an optical density O.D.₆₀₀ of 0.6-0.8 at 25° C. The cells were induced with 80 μL of a 1 M isopropyl-β-D-thiogalactoside (IPTG) stock solution and grown for another 20 h at 25° C.

[0143] The cells were harvested by centrifugation for 15 min in a JA-10 Beckmann rotor at 5000 rpm at 4° C. The cell pellet was stored until further use at −20° C.

[0144] The pellets of 4×800 mL expression were thawed on ice and resuspended in 100 mL lysisbuffer containing 50 mM HEPES at pH 7.7, 300 mM NaCl, 10% glycerol, 10% bugbuster (Novagen, 10×), two tablets of protease-inhibitor mix (Complete Tabletes EDTA-free, Roche) and 1% triton X-100. The cell suspension was incubated under gentle rocking for 20 min at room temperature.

[0145] Cell lysis was performed via ultra sonification using a Branson sonotrode. The chosen parameters for sonification were the following:

[0146]

	amplitude:	60%
	duration:	3 × 3 min
	maximal allowed temperature:	37° C.
	pulse duration:	0.5 sec
	duty cycle:	0.1 sec

[0147] The resulting suspension was centrifuged in a JA-25.50 rotor (Beckmann) at 25.000 rpm for 1 hour at 4° C.

[0148] The supernatant was loaded onto a Ni-NTA-column (resin was from Quiagen, column adapter from Pharmacia). The column had a bed volume of 3 mL and was equilibrated with 5 column volumes (CV) of starting buffer (50 mM HEPES pH 7.7; 300 mM NaCl; 10% glycerol and 10 mM imidazole). The sample was loaded with a flow rate of 1 mL/min at 4° C. using a BioRad Econopump. Then the column was mounted on a BioRad BioLogic-LP chromatography system and washed with 5-10 CVs of 50 mM HEPES pH 7.7, 300 mM NaCl, 10% glycerol, 10 mM imidazole and 10 mM N,N-dimethylundecylamin-N-oxide (C11DAO) at a rate of 1 mL/min. Another more stringent washing step was performed by applying step gradients consisting of the above washing buffer containing 20 mM and 50 mM imidazole, respectively. At this point, pure DHODH was eluted with 50 mM HEPES pH 7.7, 300 mM NaCl, 10% glycerol, 200 mM imidazole and 10 mM N,N-dimethylundecylamin-N-oxide. Elution was carried out with a flow rate of 0.5 mL/min and the eluate was collected in 4 mL fractions. Fractions containing hDHODH(Met30-Arg396) are characterized by a bright yellow colour and showed full activity in an in vitro assay (as described above/below).

[0149] Fractions containing hDHODH were combined (approx. 10 mL) and dialysed against 3 L of buffer containing 50 mM HEPES pH 7.7, 400 mM NaCl, 30% glycerol, 1 mM EDTA and 10 mM N,N-dimethylundecylamin-N-oxide overnight at 4° C. The dialysed protein sample was concentrated to a final concentration of 20 mg/mL using an Ultrafree 4/YM-30 device from Millipore. During the concentrating procedure the temperature was kept at 4° C. The protein concentration was determined spectrometrically. The His-tag was not removed for further studies.

[0150] Finally, aliquots of 50 μL were flash frozen in liquid nitrogen and stored at −80° C. until further use.

Crystallization and Data Collection

[0151] Human his10-hDHODH(Met30-Arg396) was co-crystallized with compound 1 and compound 2 at 20° C. using the hanging-drop vapour diffusion method. Drops were formed by mixing equal amounts of 20 mg/ml protein in 50 mM HEPES pH 7.7, 400 mM NaCl, 30% glycerol, 1 mM EDTA and 10 mM N,N-dimethylundecylamin-N-oxide (C11DAO) with a precipitant solution of 0.1 M acetate pH 4.6-5.0, 40 mM C11DAO, 20.8 mM N,N-dimethyldecylamine-N-oxide (DDAO), 2 mM dihydroorotate (DHO), 1.8-2.4 M ammonium sulfate, 1 mM compound 1 or 2. The hanging drops were incubated against 0.5 mL reservoir of 0.1 M acetate pH 4.8, 2.4-2.6 M ammonium sulfate and 30% glycerol. The crystallization conditions were screened by variation of pH versus ammonium sulfate concentration using a small grid screen (see FIG. 2):

[0152] The same procedure was applied to obtain single crystals of DHODH(Met30-Arg396) in complex with compounds 3, 4, 5, 6, 7, 8, 9 and 10. Compounds 5 and 6 were synthesized as racemic mixtures due to the presence of a stereo center at the five membered ring. The racemic mixtures were used for crystallization experiments.

[0153] Crystals usually appeared as small cubes within three days. They usually reached a full size of 0.2×0.2×0.2 mm within three to four weeks. The protein crystallized in the space group P3₂21. Crystals were harvested with pre-mounted loops of size 0.5 mm (Hampton Research) and were flash frozen directly in the cryo stream of the measurement device.

[0154] Data were collected at the beamline BW6 at the DESY Hamburg on a MAR-CCD camera. A total of 120 frames (0.5° each) were collected from a human DHODH(Met30-Arg396) crystal co-crystallized with compound 1. For the crystal cocrystallized with compound 2 a total of 85 frames (1° each) was recorded. The crystals were maintained at a temperature of 100 K during data collection. The indexing and integration of the reflection intensities were performed with the program MOSFLM (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Data were scaled and merged with SCALA and reduced to structure factor amplitudes with TRUNCATE, both from the CCP4 program suite (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). At this stage 5% and 10% (the “test set”) of unique reflections were flagged for cross validation to calculate the free R-factor (R_free) during the refinement process later on for compound 1 and compound 2, respectively. The remaining 95% and 90% of the reflections constituted the “working set” for calculation of the R-factor (R), respectively. The statistics of data collection are shown in table 1 and table 2.

[0155]

TABLE 1
Crystal & Data collection statistics for compound 1
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.69 b = 90.69 c = 123.22
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	2.35
	B. Data Collection
	X-Ray source	DESY BW6
	Wavelength (Å)	1.05
	Total/unique reflections	91431/24977
	Completeness (%)	98.2 (99.0)
	I/sigma	23.9 (6.5)
	Rmerge (%)	5.7 (20.2)

[0156]

TABLE 2
Crystal & Data collection statistics for compound 2
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.65 b = 90.65 c = 123.07
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	2.4
	B. Data Collection
	X-Ray source	DESY BW6
	Wavelength (Å)	1.05
	Total/unique reflections	101935/22253
	Completeness (%)	95.8 (97.1)
	I/sigma	14.6 (3.8)
	Rmerge (%)	9.1 (38.1)

[0157] Datasets for the crystals of human DHODH(Met30-Arg396) co-crystallized with compounds 3, 4, 6, 7, 8, 9 and 10 were also collected at the beamline BW6 at the DESY Hamburg on a MAR-CCD camera. Co-crystals with compound 5 were recorded at an in house generator using CuKα radiation and a MAR-dtb image plate.

[0158] A total of 55 frames, 65 frames, 96 frames, 62 frames, 120 frames, 60 frames, 100 frames and 100 frames (1° each) were collected from human DHODH(Met30-Arg396) crystals co-crystallized with compound 3, 4, 5, 6, 7, 8, 9 and 10 respectively. The crystals were maintained at a temperature of 100 K during data collection. The indexing and integration of the reflection intensities were performed with the program MOSFLM (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Data were scaled and merged with SCALA and reduced to structure factor amplitudes with TRUNCATE, both from the CCP4 program suite (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). At this stage 5% or 10% (the “test set”) of unique reflections were flagged for cross validation to calculate the free R-factor (R_free) during the refinement process. The remaining 95% or 90% of the reflections constituted the “working set” for calculation of the R-factor (R), respectively. The statistics of data collection are shown in tables 5 to 12, respectively.

[0159]

TABLE 5
Crystal & Data collection statistics for compound 3
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.43 b = 90.43 c = 123.00
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	1.95
	B. Data Collection
	X-Ray source	DESY BW6
	Wavelength (Å)	1.05
	Total/unique reflections	142628/42908
	Completeness (%)	99.8/99.9
	I/sigma	12.6/3.4
	Rmerge (%)	8.2/38.3

[0160]

TABLE 6
Crystal & Data collection statistics for compound 4
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.65 b = 90.65 c = 123.21
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	2.15
	B. Data Collection
	X-Ray source	DESY BW6
	Wavelength (Å)	1.05
	Total/unique reflections	124056/32175
	Completeness (%)	99.2/99.0
	I/sigma	14.7/5.7
	Rmerge (%)	7.1/24.8

[0161]

TABLE 7
Crystal & Data collection statistics for compound 5
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.30 b = 90.30 c = 123.09
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	2.2
	B. Data Collection
	X-Ray source	CuKα
	Wavelength (Å)	1.54
	Total/unique reflections	171127/30057
	Completeness (%)	99.9 (99.9)
	I/sigma	4.0/1.9
	Rmerge (%)	15.4/43.5

[0162]

TABLE 8
Crystal & Data collection statistics for compound 6
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.44 b = 90.44 c = 123.20
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	1.9
	B. Data Collection
	X-Ray source	DESY BW 6
	Wavelength (Å)	1.05
	Total/unique reflections	173775/46257
	Completeness (%)	99.4/99.9
	I/sigma	13.8/2.8
	Rmerge (%)	8.5/46.0

[0163]

TABLE 9
Crystal & Data collection statistics for compound 7
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.74 b = 90.74 c = 122.88
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	1.9
	B. Data Collection
	X-Ray source	DESY BW 6
	Wavelength (Å)	1.05
	Total/unique reflections	341319/46198
	Completeness (%)	98.6/99.7
	I/sigma	23.5/5.1
	Rmerge (%)	8.2/21.8

[0164]

TABLE 10
Crystal & Data collection statistics for compound 8
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.56 b = 90.56
		c = 123.06
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	1.8
	B. Data Collection
	X-Ray source	DESY BW 6
	Wavelength (Å)	1.05
	Total/unique reflections	190208/53993
	Completeness (%)	98.8/96.7
	I/sigma	16.7/2.9
	Rmerge (%)	6.3/38.3

[0165]

TABLE 11
Crystal & Data collection statistics for compound 9
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.29 b = 90.29
		c = 122.69
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	2.0
	B. Data Collection
	X-Ray source	DESY BW 6
	Wavelength (Å)	1.05
	Total/unique reflections	103711/39080
	Completeness (%)	98.6/99.0
	I/sigma	14.1/3.9
	Rmerge (%)	6.5/24.8

[0166]

TABLE 12
Crystal & Data collection statistics for compound 10
	A. Crystal data
	Spacegroup	P3221
	Cell dimensions (Å)	a = 90.75 b = 90.75
		c = 122.71
	Molecules/asymmetric unit	1
	Matthews' constant (Vm)(Å3/Da)	4.1
	Maximum resolution (Å)	1.8
	B. Data Collection
	X-Ray source	DESY BW 6
	Wavelength (Å)	1.05
	Total/unique reflections	326425/54728
	Completeness (%)	99.9/100
	I/sigma	27.5/6.0
	Rmerge (%)	6.0/30.6

Structure Determination and Refinement of DHODH/Compound 1 Complex

[0167] The structure for the human DHODH(Met30-Arg396) in complex with compound 1 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.5 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 35.6% and a correlation coefficient of 69.4% for compound 1 complex.

[0168] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX protocols. Finally, SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program 0 (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of compound 1 could be interpreted unambiguously.

[0169] A pdb file for compound 1 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 1 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), two sulfate ions (SO4), one molecule of compound 1 (INH) and 153 water molecules (TIP) (see Table 29). The model is well refined and has very good geometry. The refinement process which included data from 12.0-2.35 Å resulted in an R-factor of 18.5% and a free R-factor of 21.7%. With the exception of glycine residues, 92.4% (278) of the residues are located in the most favoured region of the ramachandran plot and 7.6% (22) cluster in the additional allowed regions. Table 13 summarizes the refinement statistics for the inhibitor compound 1 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.50 to 2.35.

[0170] The N-terminal His tag could not be detected in the electron density map.

[0171]

TABLE 13
Refinement Statistics for DHODH/compound 1 complex
	R-factor (%)	18.5 (19.6)
	Rfree	21.7 (24.2)
	RMS deviation from ideal values
	bond length (Å)	0.006
	Bond angle (°)	1.2
	Dihedral angles (°)	21.4
	Improper angles (°)	0.83

Structure Determination and Refinement of DHODH/Compound 2 Complex

[0172] The structure for the human DHODH(Met30-Arg396) in complex with compound 2 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.5 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 33.8% and a correlation coefficient of 68.2% for the DHODH/compound 2 complex.

[0173] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally a SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 2 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the presence of two alternative conformations of compound 2. In one conformation (conformation A) the carboxy group interacts with residues Gln 47 and Arg 136, whereas in the second conformation (conformation B) the interaction involves residues His 56 and Tyr 356 (see above). For each conformation a separate DHODH/compound 2 complex was subjected to refinement.

[0174] Pdb files for the compound 2 in conformation A and B were created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). Both compounds were energy minimized and built into the electron density manually. Topology and parameter files for compound 2 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol., 273, 371-376). After an additional round of model building and water picking using CNX, another complete round of refinement was performed. The final model included the human DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), four sulfate ions (SO4), one molecule of compound 2 (INH) either in conformation A or conformation B and 250 water molecules (TIP) (see Tables 30 and 31). The models are well refined and show very good geometry. The refinement process which included data from 12.0-2.4 Å resulted in an R-factor of 17.5% and a free R-factor of 21.1% for conformation A complex and an R-factor of 17.6% and a free R-factor of 21.6% for conformation B complex, respectively. With the exception of glycine residues, 91.7% (276) of the residues are located in the most favoured region of the ramachandran plot and 8.3% (24) cluster in the additional allowed regions. Table 14 summarizes the refinement statistics for compound 2 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.55 to 2.40.

[0175]

TABLE 14
Refinement Statistics for DHODH/compound 2 complex
	Conformation A	Conformation B
R-factor (%)	17.5 (19.6)	17.6 (19.4)
Rfree	21.1 (23.6)	21.6 (23.2)
RMS deviation from ideal values
bond length (Å)	0.005	0.005
Bond angle (°)	1.2	1.2
Dihedral angles (°)	21.3	21.3
Improper angles (°)	0.81	0.81

Structure Determination and Refinement of DHODH/Compound 3 Complex

[0176] The structure for the human DHODH(Met30-Arg396) in complex with compound 3 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 33.9% and a correlation coefficient of 72.5 for the DHODH/compound 3 complex.

[0177] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 3 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the presence of two alternative conformations of compound 3. In one conformation (conformation A) the carboxy group interacts with residues Gln 47 and Arg 136, whereas in the second conformation (conformation B) the interaction involves residues His 56 and Tyr 356 (see above). For each conformation a separate DHODH/compound 3 complex was subjected to refinement.

[0178] The pdb files for the compound 3 in conformation A and B were created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). Both compounds were energy minimized and built into the electron density manually. Topology and parameter files for compound 3 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol., 273, 371-376). After an additional round of model building and water picking using CNX, another complete round of refinement was performed. The final model included the human DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), two acetate molecules (ACT), two sulfate ions (SO4), one molecule of compound 3 (INH) either in conformation A or conformation B and 263 water molecules (WAT). Residues which are missing the coordinate file due to very poor electron density are listed in the header of the pdb files.

[0179] The models are well refined and show very good geometry. The refinement process which included data from 19.9-1.95 Å resulted in an R-factor of 18.5% and a free R-factor of 20.3% for the complex in conformation A and an R-factor of 18.5% and a free R-factor of 20.3% for the complex in conformation B, respectively. The almost identical R-factors indicate that non of the conformers A and B represent a preferred conformation. Except for non-glycine and non-proline residues 91.6% are located in the most favoured region of the ramachandran plot and 8% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 15 summarizes the refinement statistics for compound 3 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.07 to 1.95.

[0180]

TABLE 15
Refinement Statistics for DHODH/compound 3 complex
	conformation A	conformation B
R-factor (%)	18.5 (20.6)	18.5 (20.6)
Rfree	20.3 (23.5)	20.2 (23.6)
RMS deviation from ideal values
bond length (Å)	0.005	0.005
Bond angle (°)	1.2	1.2
Dihedral angles (°)	21.2	21.2
Improper angles (°)	0.81	0.81

Structure Determination and Refinement of DHODH/Compound 4 Complex

[0181] The structure for the human DHODH(Met30-Arg396) in complex with compound 4 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 34.6% and a correlation coefficient of 71.1 for the DHODH/compound 4 complex.

[0182] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 4 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the carboxy group in contact with residues His 56 and Tyr 356 in non-brequinar-like conformation.

[0183] A pdb file for compound 4 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 4 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), one sulfate ion (SO4), one molecule of compound 4 (INH) and 192 water molecules (TIP).

[0184] The model is well refined and shows very good stereochemical geometry. The refinement process which included data from 19.9-2.15 Å resulted in an R-factor of 20.1% and a free R-factor of 22.1%. Except for non-glycine and non-proline residues 91.6% of the residues are located in the most favoured region of the ramachandran plot and 8% and 0.3% cluster in the additional allowed or generously allowed regions, respectively. There are no residues in the disallowed region. Table 16 summarizes the refinement statistics for compound 4 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.28 to 2.15.

[0185]

TABLE 16
Refinement Statistics for DHODH/compound 4 complex
	R-factor (%)	20.1 (19.1)
	Rfree	22.1 (20.9)
	RMS deviation from ideal values
	bond length (Å)	0.005
	Bond angle (°)	1.2
	Dihedral angles (°)	21.5
	Improper angles (°)	0.80

Structure Determination and Refinement of DHODH/Compound 5 Complex

[0186] The structure for the human DHODH(Met30-Arg396) in complex with compound 5 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 33.8% and a correlation coefficient of 71.5 for the DHODH/compound 5 complex.

[0187] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 5 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the carboxy group in contact with residues His 56 and Tyr 356 in non-brequinar-like conformation. Interestingly the protein's active site discriminates between the S- and R-enantiomere. Inspection of the corresponding electron density unequivocally shows the presences of the R-enantiomere only.

[0188] A pdb file for compound 5 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 5 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), two sulfate ions (SO4), one molecule of compound 5 (INH) and 287 water molecules (TIP).

[0189] The model is well refined and shows very good stereochemical geometry. The refinement process which included data from 25.5-2.2 Å resulted in an R-factor of 18.3% and a free R-factor of 20.9%. Except for non-glycine and non-proline residues 92.6% of the residues are located in the most favoured region of the ramachandran plot and 7% and 0.3% cluster in the additional allowed or generously allowed regions, respectively. There are no residues in the disallowed region. Table 17 summarizes the refinement statistics for compound 5 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.34 to 2.2.

[0190]

TABLE 17
Refinement Statistics for DHODH/compound 5 complex
	R-factor (%)	18.3 (19.4)
	Rfree	20.9 (22.0)
	RMS deviation from ideal values
	bond length (Å)	0.005
	Bond angle (°)	1.2
	Dihedral angles (°)	21.3
	Improper angles (°)	0.83

Structure Determination and Refinement of DHODH/Compound 6 Complex

[0191] The structure for the human DHODH(Met30-Arg396) in complex with compound 6 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 32.7% and a correlation coefficient of 74.5 for the DHODH/compound 6 complex.

[0192] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 6 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed that the inhibitor molecule adopts both the brequinar and non-brequinar binding mode. The carboxy group is in contact with both anion binding sites. Interestingly the protein's active site discriminates between the S- and R-enantiomere. Inspection of the corresponding electron density unequivocally shows the presences of the R-enantiomere only.

[0193] A pdb file for compound 6 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 6 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), one sulfate ion (SO4), one molecule of compound 6 (INH) and 312 water molecules (TIP).

[0194] The models are well refined and show very good geometry. The refinement process which included data from 19.3-1.9 Å resulted in an R-factor of 18.5% and a free R-factor of 20.8% for the complex in conformation A and an R-factor of 18.5% and a free R-factor of 20.7% for the complex in conformation B, respectively. The almost identical R-factors indicate that non of the conformers A and B represent a preferred conformation. Except for non-glycine and non-proline residues 92.6% are located in the most favoured region of the ramachandran plot and 7.4% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 18 summarizes the refinement statistics for compound 6 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.02 to 1.9.

[0195]

TABLE 18
Refinement Statistics for DHODH/compound 6 complex
	conformation A	conformation B
R-factor (%)	18.5 (21.1)	18.5 (21.2)
Rfree	20.8 (21.5)	20.7 (21.6)
RMS deviation from ideal values
bond length (Å)	0.005	0.005
Bond angle (°)	1.2	1.2
Dihedral angles (°)	21.3	21.3
Improper angles (°)	0.79	0.79

Structure Determination and Refinement of DHODH/Compound 7 Complex

[0196] The structure for the human DHODH(Met30-Arg396) in complex with compound 7 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 32.7% and a correlation coefficient of 73.9 for the DHODH/compound 7 complex.

[0197] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 7 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the carboxy group in contact with residues His 56 and Tyr 356 in non-brequinar-like conformation addressing subsite 3. In compound 7 a hydroxy group at 3-position at the five membered ring was introduced creating a stereo center at this position. The racemic mixture was used for crystallization experiments. Analysis of the electron density reveals the presence of both enantiomeres. Interestingly only the R-enantiomere is able to form additional contacts to the side chains of residues Gln47 and Arg136 and to a conserved water molecule. As is clearly shown from experimental data compound 7 is able to form interactions with both subsite 2 and subsite 3 at the same time. This feature clearly discriminates this compound class from, for example, compounds 2, 6 and 10 which can address both binding sites utilizing alternative conformations but not at the same time.

[0198] A pdb file for compound 7 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 7 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), two sulfate ions (SO4), one molecule of compound 7 (INH) and 229 water molecules (TIP).

[0199] The model is well refined and shows very good stereochemical geometry. The refinement process which included data from 17.0-2.0 Å resulted in an R-factor of 17.5% and a free R-factor of 20.4% for the R-form and S-form. Except for non-glycine and non-proline residues 92.3% of the residues are located in the most favoured region of the ramachandran plot and 7.7% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 19 summarizes the refinement statistics for compound 7 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.13 to 2.0.

[0200]

TABLE 19
Refinement Statistics for DHODH/compound 7 complex
		R-form	S-form
	R-factor (%)	17.5 (17.3)	17.5 (17.3)
	Rfree	20.4 (21.4)	20.4 (21.4)
	RMS deviation from ideal values
	bond length (Å)	0.005	0.008
	Bond angle (°)	1.2	1.2
	Dihedral angles (°)	21.2	21.2
	Improper angles (°)	0.82	0.81

Structure Determination and Refinement of DHODH/Compound 8 Complex

[0201] The structure for the human DHODH(Met30-Arg396) in complex with compound 8 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 33.3% and a correlation coefficient of 73.9 for the DHODH/compound 8 complex.

[0202] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 8 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the carboxy group in contact with residues His 56 and Tyr 356 in non-brequinar-like conformation addressing subsite 3. In compound 8 a hydroxy group at 5-position at the five membered ring was introduced creating a stereo center at this position. The racemic mixture was used for crystallization experiments. Analysis of the electron density reveals that both enantiomeres fit into the electron density. The R-enantiomere appears to be positioned in a more favourable position to form interactions with subsite 3 whereas in the S-enantiomere the hydroxy group protrudes into the direction of subsite 4 (remote hydrophobic pocket) in a less favourable manner.

[0203] A pdb file for compound 8 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 8 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), five sulfate ions (SO4), one molecule of compound 8 (INH) and 218 water molecules (TIP).

[0204] The model is well refined and shows very good stereochemical geometry. The refinement process which included data from 19.0-1.8 Å resulted in an R-factor of 18.2% and a free R-factor of 19.6% for the R-form and S-form (statistics are given only for R-form). Except for non-glycine and non-proline residues 91.6% of the residues are located in the most favoured region of the ramachandran plot and 8.4% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 20 summarizes the refinement statistics for compound 8 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 1.91 to 1.8.

[0205]

TABLE 20
Refinement Statistics for DHODH/compound 8 complex
	R-factor (%)	18.2 (22.1)
	Rfree	19.6 (24.6)
	RMS deviation from ideal values
	bond length (Å)	0.005
	Bond angle (°)	1.2
	Dihedral angles (°)	21.2
	Improper angles (°)	0.83

Structure Determination and Refinement of DHODH/Compound 9 Complex

[0206] The structure for the human DHODH(Met30-Arg396) in complex with compound 9 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 32.8% and a correlation coefficient of 73.6 for the DHODH/compound 9 complex.

[0207] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 9 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the carboxy group in contact with residues Gln 47 and Arg 136 and a conserved water molecule in a unique brequinar-like conformation addressing subsite 2 only. In this conformation the sulfur atom of the five membered ring comes into close contact to Val 134 and Val 143 which form in part subsite 4 (remote hydrophobic pocket).

[0208] A pdb file for compound 9 was created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). After energy minimization the compound was built into the electron density manually. Topology and parameter files for compound 9 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol. 273, 371-376). After an additional round of model building and water picking using CNX another complete round of refinement was performed. The final model included the DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), one acetate molecule (ACT), five sulfate ions (SO4), one molecule of compound 9 (INH) and 291 water molecules (TIP).

[0209] The model is well refined and shows very good stereochemical geometry. The refinement process which included data from 17.2-2.0 Å resulted in an R-factor of 18.1% and a free R-factor of 20.0%. Except for non-glycine and non-proline residues 92.1% of the residues are located in the most favoured region of the ramachandran plot and 7.9% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 21 summarizes the refinement statistics for compound 9 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 2.13 to 2.0.

[0210]

TABLE 21
Refinement Statistics for DHODH/compound 9 complex
	R-factor (%)	18.1 (19.7)
	Rfree	20.0 (22.0)
	RMS deviation from ideal values
	bond length (Å)	0.005
	Bond angle (°)	1.2
	Dihedral angles (°)	21.2
	Improper angles (°)	0.80

Structure Determination and Refinement of DHODH/Compound 10 Complex

[0211] The structure for the human DHODH(Met30-Arg396) in complex with compound 10 was solved using the method of molecular replacement (MR). The free accessible pdb entry 1D3G.pdb was used as a search model. The ligands brequinar and DDQ as well as all of the water molecules were removed prior to the MR search. The search model included the polypeptide chain of hDHODH(Met30-Arg396), one molecule of orotate, one molecule of the cofactor flavinmononucleotide (FMN) and one acetate molecule which was present under the crystallization conditions. A standard rotational and translational molecular replacement search at 3.0 Å was performed using the program molrep (Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.). Solutions for both the rotational and translational search were well above the next ranking solutions. The MR resulted in an R-factor of 32.8% and a correlation coefficient of 74.1 for the DHODH/compound 10 complex.

[0212] In a first round of refinement the MR model was subjected to rigid body refinement and a slow cooling simulated annealing protocol using a maximum likelihood target to remove model bias (Accelrys Inc. CNX program suite, CNX2002). Additionally, an individual b-factor refinement was carried out using standard CNX-protocols. Finally SIGMAA weighted 2Fo-Fc and Fo-Fc electron density maps were calculated and displayed together with the protein model in the program O (DatOno A B; Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjelgaard, M. (1991). Acta Cryst. A47, 110-119.). The resulting experimental electron density was so excellent that the conformation of the inhibitor compound 10 could be interpreted unambiguously. The electron density around the five-membered ring carrying the carboxy group clearly showed the presence of two alternative conformations of compound 10. In one conformation (conformation A) the carboxy group interacts with residues Gln 47 and Arg 136, whereas in the second conformation (conformation B) the interaction involves residues His 56 and Tyr 356 (see above). For each conformation a separate DHODH/compound 10 complex was subjected to refinement.

[0213] The pdb files for the compound 10 in conformation A and B were created using the program MOE (Chemical Computing Group Inc., MOE 2002.02). Both compounds were energy minimized and built into the electron density manually. Topology and parameter files for compound 10 were created using the program Xplo2d (Uppsala Software Factory; Kleywegt, G. M. (1997) J. Mol. Biol., 273, 371-376). After an additional round of model building and water picking using CNX, another complete round of refinement was performed. The final model included the human DHODH(Met30-Arg396) protein, the cofactor flavinmononucleotide (FMN), one orotate molecule (ORO), two acetate molecules (ACT), four sulfate ions (SO4), one molecule of compound 10 (INH) either in conformation A or conformation B and 226 water molecules (TIP). Residues which are missing the coordinate file due to very poor electron density are listed in the header of the pdb files.

[0214] The models are well refined and show very good geometry. The refinement process which included data from 19.5-1.8 Å resulted in an R-factor of 19.5% and a free R-factor of 20.5% for the complex in conformation A and for the complex in conformation B, respectively. The identical R-factors indicate that non of the conformers A and B represent a preferred conformation. Except for non-glycine and non-proline residues 91.6% are located in the most favoured region of the ramachandran plot and 8.4% cluster in the additional allowed regions. There are no residues in the disallowed region. Table 22 summarizes the refinement statistics for compound 10 in complex with human DHODH. Values in parentheses give the R-factor and R_free-factors, respectively, for the last resolution bin ranging from 1.91 to 1.8.

[0215]

TABLE 22
Refinement Statistics for DHODH/compound 10 complex
	conformation A & B
	R-factor (%)	19.5 (20.5)
	Rfree	20.5 (22.7)
	RMS deviation from ideal values
	bond length (Å)	0.005
	Bond angle (°)	1.2
	Dihedral angles (°)	21.9
	Improper angles (°)	0.82

[0216] While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.

[0217] The following compounds are preferred: 3-(Biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(2′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(3′-Ethoxy-3,5-difluoro-biphenyl-4-yl-carbamoyl)-thiophene-2-carboxylic acid; 3-(3,5-Difluoro-2′,4′-dimethoxy-biphenyl-4-yl-carbamoyl)-thiophene-2-carboxylic acid; 3-(2,3,5,6-Tetrafluoro-2′-methoxy-biphenyl-4-yl-carbamoyl)-thiophene-2-carboxylic acid; 3-(2′-Chloro-3,5-difluoro-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(3,5,2′-Trifluoro-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(2-Chloro-2′-methoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(2,3,5,6-Tetrafluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(3,5-Difluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-2-carboxylic acid; 3-(Biphenyl-4-ylcarbamoyl)-furan-2-carboxylic acid; 4-(Biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(2-Chloro-2′-methoxy-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(3,5,2′-Trifluoro-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(3′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(2′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(3,5-Difluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 4-(Biphenyl-4-ylcarbamoyl)-furan-3-carboxylic acid; 2-(Biphenyl-4-ylcarbamoyl)-thiophene-3-carboxylic acid; 2-(Bi-phenyl-4-ylcarbamoyl)-furan-3-carboxylic acid; 3-(3-Fluoro-3′-methoxy-biphenyl-4-yl-carbamoyl)-cyclopent-2-ene-1,2-dicarboxylic acid; 2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-ene-1,3-dicarboxylic acid; 2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid methyl ester; Cyclopent-1-ene-1,2-dicarboxylic acid 1-[(3-fluoro-3′-methoxy-biphenyl-4-yl)-amide]2-hydroxyamide; 3-Hydroxy-2-(2,3,5,6-tetrafluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid; 5-Hydroxy-2-(2,3,5,6-tetrafluoro-3′-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid; 2-(3′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid; 2-(3′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-5-hydroxy-cyclo-pent-1-enecarboxylic acid; 2-(1′,3′di-methoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid; 2-(1′,3′di-methoxy-3,5-difluoro-biphenyl-4-yl-carbamoyl)-5-hydroxy-cyclopent-1-enecarboxylic acid; 3-Hydroxy-2-(3,5,2′-trifluoro-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid; 5-Hydroxy-2-(3,5,2′-trifluoro-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid; 2-(2-Chloro-2′-methoxy-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid; 2-(2-Chloro-2′-methoxy-biphenyl-4-ylcarbamoyl)-5-hydroxy-cyclopent-1-enecarboxylic acid; 2-(2′-Chloro-3,5-difluoro-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid; 2-(2′-Chloro-3,5-difluoro-biphenyl-4-ylcarbamoyl)-5-hydroxy-cyclopent-1-enecarboxylic acid; 2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid; 2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-5-hydroxy-cyclopent-1-enecarboxylic acid; trans 2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; cis-2-(3-Fluoro-3′-methoxy-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(2′-Chloro-3,5-difluoro-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(3,5-Difluoro-2′,4′-dimethoxy-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(3′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(2′-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(Biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(2,3,5,6-Tetrafluoro-3′-trifluoro-methoxy-biphenyl-4-ylcarbamoyl)-cyclopentane carboxylic acid; 2-(3,5-Difluoro-3′-trifluoro-methoxy-biphenyl-4-yl-carbamoyl)-cyclopentane carboxylic acid

[0218]

TABLE 25
	Consensus
Structure	Score
	−63.04
	−61.85
	−60.26
	−59.46
	−58.50
	−58.21
	−58.13
	−58.12
	−58.05
	−57.99
	−57.66
	−57.60
	−57.56
	−57.55
	−57.51
	−56.85
	−56.85
	−56.72
	−56.71
	−56.31
	−57.18
	−57.14
	−57.00
	−56.93
	−56.25
	−55.96
	−55.93
	−55.89
	−55.67
	−55.64
	−55.58
	−55.52
	−55.51
	−55.29
	−55.14
	−55.10
	−54.92
	−54.72
	−54.51
	−54.49
	−54.47
	−54.47
	−54.38
	−54.35
	−54.35
	−54.29
	−54.29
	−54.28
	−54.16
	−54.10
	−54.10
	−54.07
	−54.05
	−54.04
	−53.92
	−53.92
	−53.79
	−53.75
	−53.73
	−53.70
	−53.56
	−53.54
	−53.21
	−53.20
	−53.18
	−53.15
	−53.15
	−53.08
	−53.01
	−53.01
	−53.00
	−52.99
	−52.89
	−52.74
	−52.73
	−52.69
	−52.65
	−52.60
	−52.58
	−52.57
	−52.51
	−52.49
	−52.33
	−52.30
	−52.12
	−52.08
	−52.04
	−51.98
	−51.91
	−51.86
	−51.76
	−51.76
	−51.74
	−51.66
	−51.65
	−51.55
	−51.54
	−51.45
	−51.40
	−51.37

[0219]

TABLE 29
CRYST1	90.651  90.651  123.072  90.00  90.00  120.00  P  32  2  1  12
ORIGX1	1.000000	0.000000	0.000000	0.00000
ORIGX2	0.000000	1.000000	0.000000	0.00000
ORIGX3	0.000000	0.000000	1.000000	0.00000
SCALE1	0.011031	0.006369	0.000000	0.00000
SCALE2	0.000000	0.012738	0.000000	0.00000
SCALE3	0.000000	0.000000	0.008125	0.00000
ATOM	2779	N1	FMN	398	41.764	36.130	8.647	1.00	13.22
ATOM	2780	C2	FMN	398	42.155	35.485	9.782	1.00	16.74
ATOM	2781	O2	FMN	398	41.551	35.587	10.834	1.00	15.99
ATOM	2782	N3	FMN	398	43.334	34.654	9.723	1.00	15.64
ATOM	2783	C4	FMN	398	44.085	34.461	8.625	1.00	15.45
ATOM	2784	O4	FMN	398	45.083	33.724	8.672	1.00	15.51
ATOM	2785	C4A	FMN	398	43.662	35.157	7.396	1.00	14.11
ATOM	2786	N5	FMN	398	44.352	35.025	6.251	1.00	13.88
ATOM	2787	C5A	FMN	398	43.933	35.705	5.122	1.00	11.84
ATOM	2788	C6	FMN	398	44.672	35.590	3.867	1.00	10.31
ATOM	2789	C7	FMN	398	44.292	36.270	2.717	1.00	11.40
ATOM	2790	C7M	FMN	398	45.109	36.125	1.414	1.00	9.20
ATOM	2791	C8	FMN	398	43.119	37.130	2.739	1.00	11.94
ATOM	2792	C8M	FMN	398	42.649	37.914	1.520	1.00	13.94
ATOM	2793	C9	FMN	398	42.397	37.245	3.923	1.00	11.56
ATOM	2794	C9A	FMN	398	42.767	36.561	5.119	1.00	13.59
ATOM	2795	N10	FMN	398	42.048	36.664	6.371	1.00	13.81
ATOM	2796	C10	FMN	398	42.448	36.000	7.512	1.00	14.45
ATOM	2797	C1*	FMN	398	40.845	37.508	6.453	1.00	12.64
ATOM	2798	C2*	FMN	398	41.112	39.002	6.630	1.00	13.30
ATOM	2799	O2*	FMN	398	41.776	39.190	7.920	1.00	13.46
ATOM	2800	C3*	FMN	398	39.786	39.812	6.672	1.00	12.09
ATOM	2801	O3*	FMN	398	38.927	39.299	7.749	1.00	12.88
ATOM	2802	C4*	FMN	398	38.953	39.699	5.366	1.00	12.40
ATOM	2803	O4*	FMN	398	39.803	39.461	4.214	1.00	11.71
ATOM	2804	C5*	FMN	398	38.115	40.952	5.105	1.00	9.96
ATOM	2805	O5*	FMN	398	38.918	42.129	4.957	1.00	13.77
ATOM	2806	P	FMN	398	39.368	42.735	3.536	1.00	12.98
ATOM	2807	O1P	FMN	398	40.420	41.816	2.954	1.00	14.29
ATOM	2808	O2P	FMN	398	39.893	44.111	3.861	1.00	12.03
ATOM	2809	O3P	FMN	398	38.119	42.812	2.647	1.00	13.57
ATOM	2810	N1	ORO	399	41.668	32.377	4.927	1.00	16.79
ATOM	2811	C2	ORO	399	40.653	33.293	5.236	1.00	16.19
ATOM	2812	O2	ORO	399	40.042	33.934	4.385	1.00	20.26
ATOM	2813	N3	ORO	399	40.353	33.457	6.587	1.00	14.42
ATOM	2814	C4	ORO	399	40.966	32.794	7.654	1.00	14.86
ATOM	2815	O4	ORO	399	40.645	32.999	8.803	1.00	14.43
ATOM	2816	C5	ORO	399	42.023	31.842	7.276	1.00	14.27
ATOM	2817	C6	ORO	399	42.317	31.682	5.968	1.00	16.76
ATOM	2818	C7	ORO	399	43.403	30.705	5.524	1.00	17.77
ATOM	2819	O71	ORO	399	44.513	30.665	6.039	1.00	19.80
ATOM	2820	O72	ORO	399	42.936	29.994	4.595	1.00	18.75
ATOM	2821	S	SO4	400	56.428	40.104	34.632	1.00	33.94
ATOM	2822	O1	SO4	400	56.122	41.420	35.218	1.00	34.17
ATOM	2823	O2	SO4	400	55.206	39.280	34.611	1.00	35.21
ATOM	2824	O3	SO4	400	56.931	40.290	33.260	1.00	35.14
ATOM	2825	O4	SO4	400	57.461	39.431	35.440	1.00	35.91
ATOM	2826	C	ACT	401	24.612	49.259	4.963	1.00	34.33
C
ATOM	2827	O	ACT	401	23.428	49.625	4.658	1.00	33.50
ATOM	2828	OXT	ACT	401	24.926	48.987	6.156	1.00	35.35
ATOM	2829	CH3	ACT	401	24.980	48.156	3.942	1.00	30.98
ATOM	2830	S	SO4	402	56.699	36.609	28.290	1.00	39.30
ATOM	2831	O1	SO4	402	55.391	37.270	28.281	1.00	48.45
ATOM	2832	O2	SO4	402	56.512	35.164	28.489	1.00	46.40
ATOM	2833	O3	SO4	402	57.362	36.850	26.997	1.00	48.09
ATOM	2834	O4	SO4	402	57.515	37.166	29.380	1.00	46.88
ATOM	2835	S	SO4	403	48.271	43.913	28.816	1.00	92.32
ATOM	2836	O1	SO4	403	49.281	42.998	28.253	1.00	91.75
ATOM	2837	O2	SO4	403	47.936	43.487	30.189	1.00	91.47
ATOM	2838	O3	SO4	403	48.811	45.286	28.848	1.00	91.52
ATOM	2839	O4	SO4	403	47.056	43.882	27.977	1.00	91.67
ATOM	2840	S	SO4	404	32.887	23.014	6.481	1.00	79.75
ATOM	2841	O1	SO4	404	32.953	24.098	7.479	1.00	80.39
ATOM	2842	O2	SO4	404	32.083	23.456	5.326	1.00	79.78
ATOM	2843	O3	SO4	404	34.249	22.673	6.029	1.00	79.79
ATOM	2844	O4	SO4	404	32.257	21.829	7.091	1.00	79.81
ATOM	2845	OH2	TIP	2	35.590	55.465	−5.472	1.00	26.63
ATOM	2846	OH2	TIP	3	38.348	45.654	5.431	1.00	10.48
ATOM	2847	OH2	TIP	4	26.302	32.577	−2.704	1.00	19.39
ATOM	2848	OH2	TIP	5	32.739	49.699	5.057	1.00	5.11
ATOM	2849	OH2	TIP	6	40.173	36.489	0.177	1.00	9.37
ATOM	2850	OH2	TIP	7	28.781	46.327	21.174	1.00	10.19
ATOM	2851	OH2	TIP	8	50.103	40.154	27.008	1.00	11.09
ATOM	2852	OH2	TIP	9	52.699	35.114	39.857	1.00	14.19
ATOM	2853	OH2	TIP	10	32.651	48.949	19.281	1.00	9.20
ATOM	2854	OH2	TIP	11	31.681	31.390	6.490	1.00	17.24
ATOM	2855	OH2	TIP	12	54.417	36.438	7.903	1.00	15.61
ATOM	2856	OH2	TIP	13	48.745	30.174	−4.588	1.00	19.16
ATOM	2857	OH2	TIP	14	52.941	44.773	24.555	1.00	23.37
ATOM	2858	OH2	TIP	15	56.887	41.485	19.910	1.00	12.52
ATOM	2859	OH2	TIP	16	24.269	48.192	0.627	1.00	11.85
ATOM	2860	OH2	TIP	17	35.611	30.647	−11.558	1.00	19.10
ATOM	2861	OH2	TIP	19	27.016	52.988	8.586	1.00	12.80
ATOM	2862	OH2	TIP	20	33.134	44.858	−12.599	1.00	21.07
ATOM	2863	OH2	TIP	21	41.811	40.231	11.637	1.00	8.18
ATOM	2864	OH2	TIP	22	42.183	27.798	7.499	1.00	16.55
ATOM	2865	OH2	TIP	23	55.491	43.097	24.315	1.00	20.61
ATOM	2866	OH2	TIP	24	22.596	45.819	3.212	1.00	20.68
ATOM	2867	OH2	TIP	25	40.140	46.060	2.081	1.00	12.15
ATOM	2868	OH2	TIP	28	52.896	40.807	35.670	1.00	26.75
ATOM	2869	OH2	TIP	29	39.349	36.839	−11.592	1.00	16.06
ATOM	2870	OH2	TIP	30	29.722	63.391	4.730	1.00	30.50
ATOM	2871	OH2	TIP	31	31.088	52.800	1.900	1.00	16.24
ATOM	2872	OH2	TIP	33	48.477	40.642	9.325	1.00	18.06
ATOM	2873	OH2	TIP	34	48.151	60.664	−5.676	1.00	38.87
ATOM	2874	OH2	TIP	35	33.824	25.066	−2.250	1.00	26.85
ATOM	2875	OH2	TIP	36	27.559	36.164	−15.409	1.00	20.80
ATOM	2876	OH2	TIP	37	36.106	58.318	1.505	1.00	17.98
ATOM	2877	OH2	TIP	38	18.439	32.041	12.105	1.00	33.41
ATOM	2878	OH2	TIP	39	30.083	49.589	4.400	1.00	25.73
ATOM	2879	OH2	TIP	40	22.237	50.945	6.710	1.00	15.44
ATOM	2880	OH2	TIP	41	25.160	53.838	20.665	1.00	38.02
ATOM	2881	OH2	TIP	42	28.378	43.059	0.383	1.00	15.63
ATOM	2882	OH2	TIP	43	48.055	30.902	8.812	1.00	25.12
ATOM	2883	OH2	TIP	44	37.474	35.997	32.369	1.00	32.92
ATOM	2884	OH2	TIP	45	36.065	52.338	−1.345	1.00	20.39
ATOM	2885	OH2	TIP	46	48.124	51.068	24.354	1.00	27.11
ATOM	2886	OH2	TIP	47	31.748	42.518	−7.963	1.00	13.51
ATOM	2887	OH2	TIP	48	60.117	28.753	24.514	1.00	24.03
ATOM	2888	OH2	TIP	49	39.433	48.490	−3.629	1.00	30.32
ATOM	2889	OH2	TIP	50	48.317	58.149	0.954	1.00	30.47
ATOM	2890	OH2	TIP	51	55.691	32.327	25.490	1.00	27.61
ATOM	2891	OH2	TIP	52	64.195	35.380	20.138	1.00	19.56
ATOM	2892	OH2	TIP	53	58.833	49.910	15.155	1.00	27.93
ATOM	2893	OH2	TIP	54	51.798	31.467	11.336	1.00	13.39
ATOM	2894	OH2	TIP	55	39.565	45.795	−2.524	1.00	14.64
ATOM	2895	OH2	TIP	56	24.410	28.634	17.373	1.00	22.71
ATOM	2896	OH2	TIP	57	51.724	20.261	6.842	1.00	27.61
ATOM	2897	OH2	TIP	58	41.381	26.139	−9.718	1.00	20.97
ATOM	2898	OH2	TIP	59	25.055	40.702	6.956	1.00	19.36
ATOM	2899	OH2	TIP	60	23.993	41.143	9.391	1.00	25.03
ATOM	2900	OH2	TIP	61	38.010	29.506	−11.416	1.00	23.41
ATOM	2901	OH2	TIP	62	36.303	47.966	−1.088	1.00	30.41
ATOM	2902	OH2	TIP	63	38.481	26.042	1.645	1.00	31.40
ATOM	2903	OH2	TIP	64	53.281	23.398	20.183	1.00	41.21
ATOM	2904	OH2	TIP	65	59.227	43.487	12.586	1.00	16.75
ATOM	2905	OH2	TIP	66	19.680	42.939	12.681	1.00	37.20
ATOM	2906	OH2	TIP	67	34.545	51.641	22.341	1.00	33.42
ATOM	2907	OH2	TIP	68	47.228	63.064	3.669	1.00	42.40
ATOM	2908	OH2	TIP	69	45.044	42.104	−5.477	1.00	28.59
ATOM	2909	OH2	TIP	70	61.334	39.614	15.105	1.00	33.49
ATOM	2910	OH2	TIP	71	63.480	33.513	24.510	1.00	29.51
ATOM	2911	OH2	TIP	72	56.468	35.136	4.213	1.00	43.21
ATOM	2912	OH2	TIP	73	38.377	59.761	19.196	1.00	29.60
ATOM	2913	OH2	TIP	74	44.178	24.030	9.805	1.00	20.05
ATOM	2914	OH2	TIP	75	59.041	44.570	9.927	1.00	18.74
ATOM	2915	OH2	TIP	76	57.140	34.369	26.067	1.00	16.87
ATOM	2916	OH2	TIP	77	39.600	50.271	27.318	1.00	30.06
ATOM	2917	OH2	TIP	78	18.395	33.040	20.240	1.00	39.24
ATOM	2918	OH2	TIP	80	46.253	28.328	18.697	1.00	23.12
ATOM	2919	OH2	TIP	81	21.439	37.365	21.789	1.00	23.23
ATOM	2920	OH2	TIP	82	20.542	32.670	21.994	1.00	27.90
ATOM	2921	OH2	TIP	83	24.655	41.169	−5.254	1.00	24.02
ATOM	2922	OH2	TIP	84	55.024	41.551	26.503	1.00	26.29
ATOM	2923	OH2	TIP	85	38.257	32.272	33.898	1.00	23.92
ATOM	2924	OH2	TIP	86	44.348	24.278	−3.540	1.00	35.59
ATOM	2925	OH2	TIP	87	27.444	36.842	9.754	1.00	30.73
ATOM	2926	OH2	TIP	88	31.179	49.190	21.579	1.00	26.24
ATOM	2927	OH2	TIP	89	47.770	20.871	17.535	1.00	24.51
ATOM	2928	OH2	TIP	91	38.465	53.285	−2.768	1.00	34.79
ATOM	2929	OH2	TIP	92	46.308	60.185	17.231	1.00	28.55
ATOM	2930	OH2	TIP	93	28.701	66.849	4.531	1.00	40.45
ATOM	2931	OH2	TIP	94	60.902	30.818	9.650	1.00	33.92
ATOM	2932	OH2	TIP	96	19.893	46.306	21.698	1.00	30.29
ATOM	2933	OH2	TIP	97	45.510	23.104	6.071	1.00	28.35
ATOM	2934	OH2	TIP	98	55.196	41.435	21.940	1.00	16.83
ATOM	2935	OH2	TIP	99	47.253	53.876	−3.810	1.00	23.52
ATOM	2936	OH2	TIP	100	39.089	57.043	−2.142	1.00	24.05
ATOM	2937	OH2	TIP	101	42.036	65.124	6.183	1.00	24.43
ATOM	2938	OH2	TIP	102	50.161	38.979	37.857	1.00	34.83
ATOM	2939	OH2	TIP	103	24.826	38.099	6.266	1.00	52.04
ATOM	2940	OH2	TIP	104	37.666	19.146	18.942	1.00	44.29
ATOM	2941	OH2	TIP	105	34.064	23.132	21.675	1.00	37.52
ATOM	2942	OH2	TIP	106	50.935	24.631	25.846	1.00	22.54
ATOM	2943	OH2	TIP	108	43.565	44.627	28.144	1.00	49.40
ATOM	2944	OH2	TIP	109	31.117	28.110	31.273	1.00	32.65
ATOM	2945	OH2	TIP	110	20.805	49.008	19.699	1.00	46.79
ATOM	2946	OH2	TIP	111	52.650	36.241	5.934	1.00	27.82
ATOM	2947	OH2	TIP	112	58.236	26.559	10.967	1.00	36.15
ATOM	2948	OH2	TIP	113	43.031	36.731	36.240	1.00	44.91
ATOM	2949	OH2	TIP	114	24.141	50.228	27.710	1.00	47.63
ATOM	2950	OH2	TIP	115	30.276	30.961	−7.868	1.00	31.47
ATOM	2951	OH2	TIP	116	48.292	22.098	6.628	1.00	25.84
ATOM	2952	OH2	TIP	117	39.234	38.015	−14.279	1.00	31.09
ATOM	2953	OH2	TIP	119	46.519	32.215	−8.891	1.00	39.56
ATOM	2954	OH2	TIP	121	20.107	49.247	17.242	1.00	29.89
ATOM	2955	OH2	TIP	122	35.093	44.434	26.730	1.00	43.37
ATOM	2956	OH2	TIP	124	49.192	64.685	7.996	1.00	51.57
ATOM	2957	OH2	TIP	125	37.926	56.308	22.575	1.00	45.89
ATOM	2958	OH2	TIP	126	35.206	25.843	8.170	1.00	43.48
ATOM	2959	OH2	TIP	128	53.408	48.397	27.188	1.00	32.97
ATOM	2960	OH2	TIP	130	31.779	41.307	27.403	1.00	51.72
ATOM	2961	OH2	TIP	133	45.206	19.827	20.469	1.00	48.38
ATOM	2962	OH2	TIP	135	62.104	49.309	13.802	1.00	52.21
ATOM	2963	OH2	TIP	136	36.380	24.415	5.240	1.00	39.20
ATOM	2964	OH2	TIP	137	37.147	47.795	25.950	1.00	44.17
ATOM	2965	OH2	TIP	139	33.823	32.635	6.973	1.00	21.67
ATOM	2966	OH2	TIP	140	37.744	20.754	21.527	1.00	35.36
ATOM	2967	OH2	TIP	141	27.926	24.074	16.116	1.00	35.24
ATOM	2968	OH2	TIP	142	28.721	24.539	25.917	1.00	43.93
ATOM	2969	OH2	TIP	143	29.978	30.667	9.311	1.00	26.87
ATOM	2970	OH2	TIP	145	32.683	65.958	1.323	1.00	39.30
ATOM	2971	OH2	TIP	146	43.026	23.254	7.640	1.00	42.61
ATOM	2972	OH2	TIP	149	45.148	45.063	12.836	1.00	30.97
ATOM	2973	OH2	TIP	150	56.809	54.243	24.922	1.00	36.26
ATOM	2974	OH2	TIP	154	28.303	35.710	−8.702	1.00	36.61
ATOM	2975	OH2	TIP	157	49.266	20.617	1.054	1.00	39.92
ATOM	2976	OH2	TIP	161	35.433	24.497	28.823	1.00	31.77
ATOM	2977	OH2	TIP	162	48.071	19.322	10.918	1.00	50.89
ATOM	2978	OH2	TIP	170	52.214	41.890	26.882	1.00	29.94
ATOM	2979	OH2	TIP	171	43.481	68.261	20.226	1.00	50.24
ATOM	2980	OH2	TIP	173	30.552	59.616	2.762	1.00	44.94
ATOM	2981	OH2	TIP	177	49.192	23.653	29.887	1.00	45.14
ATOM	2982	OH2	TIP	179	34.894	68.176	14.392	1.00	41.94
ATOM	2983	OH2	TIP	180	34.153	33.362	32.215	1.00	41.27
ATOM	2984	OH2	TIP	183	23.367	59.922	15.715	1.00	40.54
ATOM	2985	OH2	TIP	184	37.180	22.990	−4.060	1.00	29.83
ATOM	2986	OH2	TIP	186	59.902	32.926	5.795	1.00	48.68
ATOM	2987	OH2	TIP	187	38.635	46.185	−0.225	1.00	14.36
ATOM	2988	OH2	TIP	188	52.924	26.976	2.822	1.00	20.37
ATOM	2989	OH2	TIP	189	56.875	26.651	15.240	1.00	18.86
ATOM	2990	OH2	TIP	190	55.306	25.358	16.983	1.00	13.37
ATOM	2991	OH2	TIP	191	51.595	53.593	12.466	1.00	17.70
ATOM	2992	OH2	TIP	192	27.679	24.004	18.956	1.00	35.95
ATOM	2993	OH2	TIP	193	28.677	32.820	−8.974	1.00	32.62
ATOM	2994	OH2	TIP	194	20.577	38.735	10.813	1.00	31.02
ATOM	2995	OH2	TIP	195	24.128	43.401	2.958	1.00	26.14
ATOM	2996	OH2	TIP	196	21.872	27.301	26.191	1.00	44.90
ATOM	2997	OH2	TIP	197	63.765	33.808	21.998	1.00	36.70
ATOM	2998	OH2	TIP	198	32.846	49.810	23.746	1.00	37.36
ATOM	2999	OH2	TIP	199	58.905	40.769	13.020	1.00	30.69
ATOM	3000	OH2	TIP	200	22.377	49.968	21.592	1.00	39.90
ATOM	3001	OH2	TIP	201	49.605	32.015	−6.500	1.00	33.85
ATOM	3002	OH2	TIP	202	19.520	32.689	24.514	1.00	40.34
ATOM	3003	OH2	TIP	203	18.186	43.942	25.261	1.00	37.04
ATOM	3004	OH2	TIP	204	31.924	23.419	9.913	1.00	41.07
ATOM	3005	OH2	TIP	205	59.551	39.040	29.664	1.00	48.01
ATOM	3006	OH2	TIP	206	24.747	35.005	−2.252	1.00	38.50
ATOM	3007	OH2	TIP	207	51.726	24.271	23.364	1.00	45.92
ATOM	3008	OH2	TIP	208	41.227	63.077	0.564	1.00	52.88
ATOM	3009	OH2	TIP	209	45.043	24.853	−7.064	1.00	63.99
ATOM	3010	OH2	TIP	210	60.297	33.503	0.872	1.00	44.71
ATOM	3011	OH2	TIP	211	55.354	57.898	−5.181	1.00	67.46
ATOM	3012	OH2	TIP	212	26.342	34.721	3.607	1.00	43.97
ATOM	3013	OH2	TIP	213	57.229	58.636	2.147	1.00	56.52
ATOM	3014	OH2	TIP	214	48.952	19.413	7.794	1.00	36.39
ATOM	3015	OH2	TIP	215	18.698	34.346	22.436	1.00	40.47
ATOM	3016	OH2	TIP	216	50.056	55.688	3.654	1.00	41.15
ATOM	3017	OH2	TIP	217	23.808	39.359	−3.697	1.00	38.56
ATOM	3018	OH2	TIP	219	30.490	25.063	28.451	1.00	52.43
ATOM	3019	OH2	TIP	220	26.031	30.526	16.823	1.00	35.58
ATOM	3020	OH2	TIP	222	54.897	58.072	2.961	1.00	48.36
ATOM	3021	OH2	TIP	223	59.398	53.141	−2.805	1.00	58.38
ATOM	3022	OH2	TIP	224	51.436	23.394	27.949	1.00	42.69
ATOM	3023	OH2	TIP	225	37.497	39.534	29.612	1.00	29.55
ATOM	3024	OH2	TIP	226	20.525	42.018	22.609	1.00	59.58
ATOM	3025	OH2	TIP	227	38.073	51.947	−4.969	1.00	45.26
ATOM	3026	OH2	TIP	228	52.416	32.620	0.869	1.00	58.50
ATOM	3027	OH2	TIP	229	58.152	50.912	12.884	1.00	32.92
ATOM	3028	OH2	TIP	230	56.059	24.385	3.859	1.00	54.19
ATOM	3029	OH2	TIP	231	51.657	20.142	23.177	1.00	49.92
ATOM	3030	OH2	TIP	232	48.247	18.532	16.124	1.00	47.86
ATOM	3031	OH2	TIP	233	49.710	20.786	19.715	1.00	37.69
ATOM	3032	OH2	TIP	234	61.171	40.499	27.294	1.00	41.21
ATOM	3033	OH2	TIP	235	60.229	28.450	9.873	1.00	39.53
ATOM	3034	OH2	TIP	236	39.482	20.654	25.665	1.00	40.24
ATOM	3035	OH2	TIP	237	21.898	39.040	23.981	1.00	49.44
ATOM	3036	OH2	TIP	238	41.482	40.544	−15.377	1.00	41.34
ATOM	3037	OH2	TIP	239	53.795	60.848	4.850	1.00	53.61
ATOM	3038	OH2	TIP	240	34.935	52.929	−3.681	1.00	35.26
ATOM	3039	OH2	TIP	241	55.320	34.524	−10.024	1.00	38.15
ATOM	3040	OH2	TIP	243	26.335	37.508	−0.149	1.00	39.86
ATOM	3041	OH2	TIP	244	50.998	60.568	3.880	1.00	65.48
ATOM	3042	OH2	TIP	246	30.232	56.037	21.276	1.00	50.32
ATOM	3043	OH2	TIP	247	25.549	38.311	8.586	1.00	39.52
ATOM	3044	OH2	TIP	248	56.414	42.750	28.581	1.00	44.10
ATOM	3045	OH2	TIP	249	50.755	57.649	7.886	1.00	35.64
ATOM	3046	OH2	TIP	250	41.230	43.187	29.095	1.00	43.86
ATOM	3047	OH2	TIP	251	44.998	22.901	28.299	1.00	53.89
ATOM	3048	OH2	TIP	252	20.352	42.557	15.132	1.00	52.49
ATOM	3049	OH2	TIP	253	26.184	65.798	8.905	1.00	43.68
ATOM	3050	OH2	TIP	254	45.893	38.490	−11.594	1.00	51.24
ATOM	3051	OH2	TIP	255	42.710	41.577	34.594	1.00	40.69
ATOM	3052	OH2	TIP	256	48.240	52.727	26.492	1.00	43.49
ATOM	3053	OH2	TIP	257	39.554	58.190	23.447	1.00	49.04
ATOM	3054	OH2	TIP	258	37.575	57.178	25.056	1.00	45.47
ATOM	3055	OH2	TIP	259	50.664	56.391	11.881	1.00	31.43
ATOM	3056	OH2	TIP	260	59.974	24.777	12.397	1.00	37.68
ATOM	3057	OH2	TIP	261	23.885	35.887	6.227	1.00	46.04
ATOM	3058	OH2	TIP	262	64.702	52.392	26.765	1.00	59.22
ATOM	3059	OH2	TIP	263	35.576	61.522	20.195	1.00	49.81
ATOM	3060	OH2	TIP	264	43.682	65.275	−7.504	1.00	43.86
ATOM	3061	OH2	TIP	266	60.870	47.912	27.467	1.00	53.93
ATOM	3062	OH2	TIP	268	51.707	34.577	42.346	1.00	45.87
ATOM	3063	OH2	TIP	269	29.465	40.196	30.722	1.00	38.31
ATOM	3064	OH2	TIP	270	22.879	53.243	8.461	1.00	43.09
ATOM	3065	OH2	TIP	272	42.793	30.638	35.734	1.00	54.91
ATOM	3066	OH2	TIP	273	39.878	24.302	0.355	1.00	42.81
ATOM	3067	OH2	TIP	274	45.874	43.477	32.353	1.00	44.64
ATOM	3068	OH2	TIP	276	60.439	26.457	22.587	1.00	58.50
ATOM	3069	OH2	TIP	277	33.501	19.630	7.711	1.00	40.97
ATOM	3070	OH2	TIP	278	31.136	37.255	33.009	1.00	49.32
ATOM	3071	OH2	TIP	279	54.504	24.817	21.938	1.00	49.97
ATOM	3072	OH2	TIP	280	47.280	60.101	19.796	1.00	43.35
ATOM	3073	OH2	TIP	282	54.430	30.932	0.309	1.00	63.58
ATOM	3074	OH2	TIP	283	61.848	32.266	15.111	1.00	38.33
ATOM	3075	OH2	TIP	284	24.901	34.423	−6.980	1.00	40.77
ATOM	3076	OH2	TIP	285	24.740	32.154	26.786	1.00	43.19
ATOM	3077	OH2	TIP	286	32.495	60.380	1.080	1.00	46.07
ATOM	3078	OH2	TIP	287	55.139	56.211	24.904	1.00	43.70
ATOM	3079	OH2	TIP	288	43.595	38.488	39.052	1.00	50.51
ATOM	3080	OH2	TIP	292	20.724	36.629	8.924	1.00	43.74
ATOM	3081	OH2	TIP	293	46.686	64.930	9.425	1.00	50.38
ATOM	3082	OH2	TIP	294	17.201	60.221	10.522	1.00	43.72
ATOM	3083	OH2	TIP	295	17.500	28.964	19.499	1.00	38.98
ATOM	3084	OH2	TIP	297	36.397	31.380	32.306	1.00	41.95
ATOM	3085	OH2	TIP	300	46.747	59.180	−13.611	1.00	47.00
ATOM	3086	OH2	TIP	301	29.632	25.523	9.658	1.00	45.27
ATOM	3087	OH2	TIP	302	50.813	58.467	0.387	1.00	40.01
ATOM	3088	OH2	TIP	303	29.510	51.948	22.195	1.00	37.26
ATOM	3089	OH2	TIP	304	34.546	62.038	23.290	1.00	43.28
ATOM	3090	OH2	TIP	305	28.994	20.945	23.473	1.00	43.57
ATOM	3091	OH2	TIP	306	50.928	49.942	27.992	1.00	49.74
ATOM	3092	OH2	TIP	307	18.603	51.462	16.940	1.00	45.75
ATOM	3093	OH2	TIP	309	42.013	36.897	−13.981	1.00	47.94
ATOM	3094	OH2	TIP	310	45.087	42.847	−9.324	1.00	47.04
ATOM	3095	C1	INH	1	55.236	47.264	0.315	0.00	19.32
ATOM	3096	C2	INH	1	55.731	48.195	−0.664	0.00	19.20
ATOM	3097	C3	INH	1	55.258	48.140	−2.050	0.00	19.12
ATOM	3098	C4	INH	1	54.265	47.124	−2.434	0.00	19.23
ATOM	3099	C5	INH	1	53.756	46.171	−1.432	0.00	19.43
ATOM	3100	C6	INH	1	52.787	45.139	−1.726	0.00	19.40
ATOM	3101	C7	INH	1	54.267	46.267	−0.057	0.00	19.29
ATOM	3102	C8	INH	1	53.065	44.157	−2.777	0.00	19.48
ATOM	3103	C9	INH	1	52.120	43.114	−3.081	0.00	19.61
ATOM	3104	F10	INH	1	52.396	42.242	−4.029	0.00	19.47
ATOM	3105	C11	INH	1	50.854	43.001	−2.347	0.00	19.73
ATOM	3106	N12	INH	1	49.946	41.963	−2.657	0.00	19.81
ATOM	3107	C13	INH	1	50.566	43.971	−1.304	0.00	19.50
ATOM	3108	F14	INH	1	49.438	43.905	−0.620	0.00	19.51
ATOM	3109	C15	INH	1	51.512	45.029	−0.990	0.00	19.42
ATOM	3110	C16	INH	1	49.182	41.562	−3.767	0.00	20.05
ATOM	3111	C17	INH	1	48.294	40.370	−3.753	0.00	20.24
ATOM	3112	C18	INH	1	49.255	42.235	−4.804	0.00	20.11
ATOM	3113	C19	INH	1	47.993	39.496	−2.733	0.00	20.33
ATOM	3114	C20	INH	1	47.042	38.465	−3.244	0.00	20.37
ATOM	3115	C21	INH	1	46.405	39.116	−4.465	0.00	20.37
ATOM	3116	C22	INH	1	47.561	39.964	−4.990	0.00	20.30
ATOM	3117	C23	INH	1	48.435	39.426	−1.307	0.00	20.38
ATOM	3118	C24	INH	1	49.215	40.225	−0.791	0.00	20.42
ATOM	3119	C25	INH	1	47.969	38.433	−0.500	0.00	20.42
ATOM	3120	C26	INH	1	55.745	49.052	−2.996	0.00	19.20
ATOM	3121	C27	INH	1	57.043	48.675	−3.568	0.00	19.22
ATOM	3122	F28	INH	1	57.052	47.408	−3.962	0.00	18.96
ATOM	3123	F29	INH	1	57.283	49.439	−4.611	0.00	18.96
ATOM	3124	F30	INH	1	58.012	48.867	−2.686	0.00	18.96
TER	1		INH	1
ATOM	1	CB	MET A	30	59.689	55.188	−5.634	1.00	78.93
ATOM	2	CG	MET A	30	59.846	54.459	−6.959	1.00	79.24
ATOM	3	SD	MET A	30	59.231	52.765	−6.869	1.00	79.21
ATOM	4	CE	MET A	30	60.653	51.913	−6.175	1.00	79.18
ATOM	5	C	MET A	30	58.206	55.626	−3.674	1.00	77.77
ATOM	6	O	MET A	30	57.247	55.273	−2.989	1.00	77.07
ATOM	7	N	MET A	30	57.559	56.411	−5.965	1.00	78.11
ATOM	8	CA	MET A	30	58.237	55.344	−5.173	1.00	78.21
ATOM	9	N	ALA A	31	59.261	56.261	−3.170	1.00	77.18
ATOM	10	CA	ALA A	31	59.357	56.584	−1.750	1.00	75.83
ATOM	11	CB	ALA A	31	60.804	56.889	−1.382	1.00	76.33
ATOM	12	C	ALA A	31	58.466	57.766	−1.386	1.00	74.57
ATOM	13	O	ALA A	31	58.120	57.955	−0.220	1.00	74.68
ATOM	14	N	THR A	32	58.098	58.559	−2.388	1.00	73.02
ATOM	15	CA	THR A	32	57.247	59.724	−2.172	1.00	70.94
ATOM	16	CB	THR A	32	57.070	60.531	−3.474	1.00	71.72
ATOM	17	OG1	THR A	32	58.350	60.991	−3.929	1.00	71.26
ATOM	18	CG2	THR A	32	56.155	61.727	−3.242	1.00	71.64
ATOM	19	C	THR A	32	55.872	59.303	−1.660	1.00	68.92
ATOM	20	O	THR A	32	55.231	60.029	−0.897	1.00	69.22
ATOM	21	N	GLY A	33	55.423	58.127	−2.086	1.00	65.85
ATOM	22	CA	GLY A	33	54.133	57.627	−1.650	1.00	61.62
ATOM	23	C	GLY A	33	52.950	58.306	−2.308	1.00	58.54
ATOM	24	O	GLY A	33	52.111	58.899	−1.630	1.00	59.44
ATOM	25	N	ASP A	34	52.875	58.220	−3.631	1.00	53.96
ATOM	26	CA	ASP A	34	51.773	58.831	−4.358	1.00	48.74
ATOM	27	CB	ASP A	34	52.285	59.470	−5.648	1.00	48.47
ATOM	28	CG	ASP A	34	51.171	60.046	−6.488	1.00	48.19
ATOM	29	OD1	ASP A	34	50.675	59.329	−7.383	1.00	47.90
ATOM	30	OD2	ASP A	34	50.783	61.210	−6.245	1.00	48.88
ATOM	31	C	ASP A	34	50.687	57.803	−4.663	1.00	45.54
ATOM	32	O	ASP A	34	50.947	56.760	−5.266	1.00	42.96
ATOM	33	N	GLU A	35	49.467	58.115	−4.237	1.00	42.40
ATOM	34	CA	GLU A	35	48.319	57.236	−4.420	1.00	39.88
ATOM	35	CB	GLU A	35	47.072	57.897	−3.824	1.00	39.71
ATOM	36	CG	GLU A	35	47.055	57.882	−2.298	1.00	41.04
ATOM	37	CD	GLU A	35	46.065	58.866	−1.695	1.00	42.39
ATOM	38	OE1	GLU A	35	44.959	59.028	−2.254	1.00	43.92
ATOM	39	OE2	GLU A	35	46.391	59.468	−0.649	1.00	40.71
ATOM	40	C	GLU A	35	48.058	56.800	−5.859	1.00	38.11
ATOM	41	O	GLU A	35	47.820	55.618	−6.109	1.00	36.81
ATOM	42	N	ARG A	36	48.107	57.738	−6.804	1.00	36.86
ATOM	43	CA	ARG A	36	47.867	57.397	−8.205	1.00	36.42
ATOM	44	CB	ARG A	36	47.761	58.650	−9.077	1.00	39.87
ATOM	45	CG	ARG A	36	46.462	59.421	−8.961	1.00	44.23
ATOM	46	CD	ARG A	36	46.287	60.321	−10.176	1.00	46.52
ATOM	47	NE	ARG A	36	45.492	61.506	−9.878	1.00	50.65
ATOM	48	CZ	ARG A	36	45.852	62.445	−9.008	1.00	52.47
ATOM	49	NH1	ARG A	36	46.997	62.336	−8.346	1.00	52.64
ATOM	50	NH2	ARG A	36	45.073	63.500	−8.804	1.00	53.33
ATOM	51	C	ARG A	36	48.950	56.509	−8.791	1.00	34.75
ATOM	52	O	ARG A	36	48.657	55.559	−9.513	1.00	34.22
ATOM	53	N	PHE A	37	50.204	56.826	−8.488	1.00	33.66
ATOM	54	CA	PHE A	37	51.316	56.048	−9.014	1.00	33.12
ATOM	55	CB	PHE A	37	52.653	56.602	−8.521	1.00	34.20
ATOM	56	CG	PHE A	37	53.836	55.879	−9.088	1.00	36.60
ATOM	57	CD1	PHE A	37	54.115	55.945	−10.444	1.00	36.51
ATOM	58	CD2	PHE A	37	54.647	55.101	−8.277	1.00	38.02
ATOM	59	CE1	PHE A	37	55.180	55.247	−10.980	1.00	38.42
ATOM	60	CE2	PHE A	37	55.714	54.398	−8.808	1.00	38.15
ATOM	61	CZ	PHE A	37	55.980	54.471	−10.161	1.00	38.74
ATOM	62	C	PHE A	37	51.217	54.577	−8.639	1.00	31.06
ATOM	63	O	PHE A	37	51.387	53.702	−9.485	1.00	30.53
ATOM	64	N	TYR A	38	50.949	54.304	−7.368	1.00	30.51
ATOM	65	CA	TYR A	38	50.833	52.924	−6.919	1.00	31.07
ATOM	66	CB	TYR A	38	50.801	52.852	−5.392	1.00	29.44
ATOM	67	CG	TYR A	38	52.169	52.881	−4.759	1.00	29.09
ATOM	68	CD1	TYR A	38	52.904	54.060	−4.694	1.00	29.44
ATOM	69	CE1	TYR A	38	54.167	54.082	−4.129	1.00	28.77
ATOM	70	CD2	TYR A	38	52.738	51.721	−4.242	1.00	26.55
ATOM	71	CE2	TYR A	38	53.996	51.731	−3.680	1.00	26.62
ATOM	72	CZ	TYR A	38	54.706	52.912	−3.626	1.00	28.87
ATOM	73	OH	TYR A	38	55.963	52.921	−3.078	1.00	29.87
ATOM	74	C	TYR A	38	49.596	52.252	−7.486	1.00	31.66
ATOM	75	O	TYR A	38	49.656	51.117	−7.954	1.00	30.99
ATOM	76	N	ALA A	39	48.476	52.965	−7.454	1.00	33.37
ATOM	77	CA	ALA A	39	47.215	52.433	−7.952	1.00	35.76
ATOM	78	CB	ALA A	39	46.076	53.365	−7.562	1.00	35.92
ATOM	79	C	ALA A	39	47.203	52.212	−9.460	1.00	37.51
ATOM	80	O	ALA A	39	46.769	51.161	−9.939	1.00	37.40
ATOM	81	N	GLU A	40	47.692	53.199	−10.203	1.00	39.90
ATOM	82	CA	GLU A	40	47.697	53.129	−11.660	1.00	41.43
ATOM	83	CB	GLU A	40	47.505	54.531	−12.247	1.00	43.66
ATOM	84	CG	GLU A	40	46.253	55.250	−11.764	1.00	47.51
ATOM	85	CD	GLU A	40	46.103	56.633	−12.372	1.00	50.59
ATOM	86	OE1	GLU A	40	46.046	56.728	−13.618	1.00	53.22
ATOM	87	OE2	GLU A	40	46.041	57.623	−11.609	1.00	51.67
ATOM	88	C	GLU A	40	48.920	52.493	−12.311	1.00	40.64
ATOM	89	O	GLU A	40	48.804	51.910	−13.387	1.00	41.18
ATOM	90	N	HIS A	41	50.085	52.585	−11.678	1.00	39.76
ATOM	91	CA	HIS A	41	51.282	52.028	−12.303	1.00	38.73
ATOM	92	CB	HIS A	41	52.275	53.153	−12.616	1.00	40.77
ATOM	93	CG	HIS A	41	51.702	54.239	−13.470	1.00	44.26
ATOM	94	CD2	HIS A	41	51.815	54.482	−14.797	1.00	45.53
ATOM	95	ND1	HIS A	41	50.869	55.218	−12.971	1.00	46.11
ATOM	96	CE1	HIS A	41	50.494	56.018	−13.954	1.00	46.63
ATOM	97	NE2	HIS A	41	51.054	55.593	−15.072	1.00	47.73
ATOM	98	C	HIS A	41	52.034	50.903	−11.605	1.00	35.82
ATOM	99	O	HIS A	41	52.166	49.809	−12.153	1.00	36.05
ATOM	100	N	LEU A	42	52.537	51.168	−10.407	1.00	33.50
ATOM	101	CA	LEU A	42	53.317	50.166	−9.688	1.00	32.13
ATOM	102	CB	LEU A	42	53.872	50.770	−8.393	1.00	30.83
ATOM	103	CG	LEU A	42	54.988	49.962	−7.723	1.00	33.78
ATOM	104	CD1	LEU A	42	55.923	50.904	−6.983	1.00	32.87
ATOM	105	CD2	LEU A	42	54.391	48.919	−6.784	1.00	33.61
ATOM	106	C	LEU A	42	52.589	48.852	−9.394	1.00	30.33
ATOM	107	O	LEU A	42	52.988	47.801	−9.893	1.00	31.41
ATOM	108	N	MET A	43	51.530	48.907	−8.593	1.00	28.07
ATOM	109	CA	MET A	43	50.781	47.701	−8.243	1.00	28.07
ATOM	110	CB	MET A	43	49.559	48.057	−7.389	1.00	24.63
ATOM	111	CG	MET A	43	49.917	48.620	−6.024	1.00	24.00
ATOM	112	SD	MET A	43	51.097	47.580	−5.115	1.00	25.98
ATOM	113	CE	MET A	43	50.029	46.223	−4.620	1.00	22.82
ATOM	114	C	MET A	43	50.350	46.873	−9.451	1.00	28.45
ATOM	115	O	MET A	43	50.534	45.657	−9.470	1.00	27.65
ATOM	116	N	PRO A	44	49.759	47.517	−10.471	1.00	30.19
ATOM	117	CD	PRO A	44	49.318	48.922	−10.520	1.00	28.99
ATOM	118	CA	PRO A	44	49.320	46.795	−11.670	1.00	30.48
ATOM	119	CB	PRO A	44	48.748	47.903	−12.545	1.00	30.20
ATOM	120	CG	PRO A	44	48.214	48.872	−11.543	1.00	30.28
ATOM	121	C	PRO A	44	50.481	46.067	−12.352	1.00	32.32
ATOM	122	O	PRO A	44	50.348	44.916	−12.767	1.00	32.75
ATOM	123	N	THR A	45	51.616	46.750	−12.468	1.00	33.19
ATOM	124	CA	THR A	45	52.796	46.170	−13.099	1.00	34.66
ATOM	125	CB	THR A	45	53.930	47.214	−13.231	1.00	35.79
ATOM	126	OG1	THR A	45	53.475	48.321	−14.019	1.00	33.62
ATOM	127	CG2	THR A	45	55.155	46.591	−13.896	1.00	35.42
ATOM	128	C	THR A	45	53.301	45.003	−12.261	1.00	36.33
ATOM	129	O	THR A	45	53.666	43.951	−12.787	1.00	36.54
ATOM	130	N	LEU A	46	53.317	45.201	−10.949	1.00	37.72
ATOM	131	CA	LEU A	46	53.770	44.173	−10.022	1.00	38.02
ATOM	132	CB	LEU A	46	53.686	44.700	−8.590	1.00	38.12
ATOM	133	CG	LEU A	46	54.340	43.856	−7.500	1.00	39.50
ATOM	134	CD1	LEU A	46	55.808	43.642	−7.839	1.00	41.34
ATOM	135	CD2	LEU A	46	54.202	44.562	−6.161	1.00	38.74
ATOM	136	C	LEU A	46	52.912	42.920	−10.164	1.00	38.63
ATOM	137	O	LEU A	46	53.430	41.806	−10.244	1.00	38.89
ATOM	138	N	GLN A	47	51.596	43.108	−10.203	1.00	38.81
ATOM	139	CA	GLN A	47	50.669	41.990	−10.329	1.00	40.49
ATOM	140	CB	GLN A	47	49.254	42.446	−9.957	1.00	40.67
ATOM	141	CG	GLN A	47	49.138	42.901	−8.503	1.00	42.61
ATOM	142	CD	GLN A	47	47.756	43.414	−8.147	1.00	44.18
ATOM	143	OE1	GLN A	47	47.259	44.366	−8.750	1.00	46.67
ATOM	144	NE2	GLN A	47	47.127	42.787	−7.159	1.00	43.17
ATOM	145	C	GLN A	47	50.688	41.377	−11.729	1.00	39.96
ATOM	146	O	GLN A	47	50.273	40.234	−11.923	1.00	39.12
ATOM	147	N	GLY A	48	51.182	42.137	−12.701	1.00	40.79
ATOM	148	CA	GLY A	48	51.260	41.634	−14.061	1.00	39.68
ATOM	149	C	GLY A	48	52.515	40.806	−14.283	1.00	39.30
ATOM	150	O	GLY A	48	52.687	40.200	−15.339	1.00	40.84
ATOM	151	N	LEU A	49	53.391	40.772	−13.283	1.00	37.80
ATOM	152	CA	LEU A	49	54.636	40.017	−13.377	1.00	37.34
ATOM	153	CB	LEU A	49	55.836	40.947	−13.175	1.00	38.41
ATOM	154	CG	LEU A	49	56.089	42.039	−14.217	1.00	38.40
ATOM	155	CD1	LEU A	49	57.229	42.929	−13.751	1.00	38.36
ATOM	156	CD2	LEU A	49	56.414	41.402	−15.558	1.00	38.65
ATOM	157	C	LEU A	49	54.717	38.886	−12.359	1.00	36.86
ATOM	158	O	LEU A	49	55.440	37.913	−12.564	1.00	36.92
ATOM	159	N	LEU A	50	53.978	39.016	−11.263	1.00	36.23
ATOM	160	CA	LEU A	50	53.992	38.009	−10.207	1.00	35.06
ATOM	161	CB	LEU A	50	54.594	38.605	−8.929	1.00	35.63
ATOM	162	CG	LEU A	50	56.039	39.102	−8.996	1.00	36.84
ATOM	163	CD1	LEU A	50	56.382	39.831	−7.707	1.00	36.77
ATOM	164	CD2	LEU A	50	56.982	37.925	−9.220	1.00	36.09
ATOM	165	C	LEU A	50	52.608	37.460	−9.886	1.00	34.37
ATOM	166	O	LEU A	50	51.627	38.206	−9.843	1.00	34.32
ATOM	167	N	ASP A	51	52.530	36.152	−9.655	1.00	33.01
ATOM	168	CA	ASP A	51	51.258	35.534	−9.309	1.00	33.05
ATOM	169	CB	ASP A	51	51.365	34.008	−9.370	1.00	34.40
ATOM	170	CG	ASP A	51	52.309	33.450	−8.331	1.00	37.10
ATOM	171	OD1	ASP A	51	53.510	33.791	−8.377	1.00	39.23
ATOM	172	OD2	ASP A	51	51.850	32.670	−7.469	1.00	38.47
ATOM	173	C	ASP A	51	50.917	35.999	−7.890	1.00	30.99
ATOM	174	O	ASP A	51	51.801	36.411	−7.135	1.00	30.97
ATOM	175	N	PRO A	52	49.633	35.935	−7.510	1.00	28.90
ATOM	176	CD	PRO A	52	48.538	35.321	−8.280	1.00	27.63
ATOM	177	CA	PRO A	52	49.161	36.357	−6.185	1.00	27.61
ATOM	178	CB	PRO A	52	47.781	35.715	−6.097	1.00	28.92
ATOM	179	CG	PRO A	52	47.313	35.772	−7.514	1.00	27.88
ATOM	180	C	PRO A	52	50.054	35.993	−4.996	1.00	25.59
ATOM	181	O	PRO A	52	50.463	36.864	−4.237	1.00	25.26
ATOM	182	N	GLU A	53	50.363	34.713	−4.836	1.00	24.82
ATOM	183	CA	GLU A	53	51.189	34.290	−3.714	1.00	25.88
ATOM	184	CB	GLU A	53	51.229	32.761	−3.632	1.00	26.19
ATOM	185	CG	GLU A	53	51.892	32.254	−2.366	1.00	27.45
ATOM	186	CD	GLU A	53	51.418	30.874	−1.956	1.00	28.77
ATOM	187	OE1	GLU A	53	51.973	30.337	−0.977	1.00	32.06
ATOM	188	OE2	GLU A	53	50.496	30.328	−2.600	1.00	27.91
ATOM	189	C	GLU A	53	52.612	34.863	−3.730	1.00	25.94
ATOM	190	O	GLU A	53	53.103	35.326	−2.698	1.00	24.19
ATOM	191	N	SER A	54	53.273	34.835	−4.887	1.00	24.50
ATOM	192	CA	SER A	54	54.625	35.380	−4.990	1.00	24.72
ATOM	193	CB	SER A	54	55.195	35.170	−6.395	1.00	26.25
ATOM	194	OG	SER A	54	55.432	33.797	−6.656	1.00	29.09
ATOM	195	C	SER A	54	54.610	36.871	−4.676	1.00	25.01
ATOM	196	O	SER A	54	55.537	37.395	−4.059	1.00	24.88
ATOM	197	N	ALA A	55	53.550	37.549	−5.111	1.00	23.57
ATOM	198	CA	ALA A	55	53.404	38.977	−4.876	1.00	22.63
ATOM	199	CB	ALA A	55	52.163	39.500	−5.602	1.00	21.92
ATOM	200	C	ALA A	55	53.285	39.221	−3.371	1.00	22.63
ATOM	201	O	ALA A	55	53.909	40.127	−2.822	1.00	22.32
ATOM	202	N	HIS A	56	52.481	38.402	−2.706	1.00	22.16
ATOM	203	CA	HIS A	56	52.304	38.533	−1.267	1.00	23.00
ATOM	204	CB	HIS A	56	51.295	37.507	−0.757	1.00	18.21
ATOM	205	CG	HIS A	56	51.244	37.422	0.734	1.00	18.62
ATOM	206	CD2	HIS A	56	51.508	36.398	1.580	1.00	16.96
ATOM	207	ND1	HIS A	56	50.926	38.503	1.527	1.00	18.90
ATOM	208	CE1	HIS A	56	50.996	38.149	2.797	1.00	19.09
ATOM	209	NE2	HIS A	56	51.349	36.878	2.857	1.00	18.86
ATOM	210	C	HIS A	56	53.620	38.348	−0.508	1.00	24.69
ATOM	211	O	HIS A	56	53.945	39.127	0.394	1.00	24.05
ATOM	212	N	ARG A	57	54.368	37.310	−0.873	1.00	25.73
ATOM	213	CA	ARG A	57	55.638	37.015	−0.224	1.00	28.93
ATOM	214	CB	ARG A	57	56.230	35.724	−0.792	1.00	32.78
ATOM	215	CG	ARG A	57	55.243	34.565	−0.760	1.00	40.35
ATOM	216	CD	ARG A	57	55.890	33.236	−1.119	1.00	45.50
ATOM	217	NE	ARG A	57	56.855	32.813	−0.110	1.00	51.35
ATOM	218	CZ	ARG A	57	57.402	31.603	−0.063	1.00	54.26
ATOM	219	NH1	ARG A	57	57.078	30.691	−0.971	1.00	54.88
ATOM	220	NH2	ARG A	57	58.270	31.303	0.896	1.00	56.37
ATOM	221	C	ARG A	57	56.625	38.163	−0.382	1.00	27.70
ATOM	222	O	ARG A	57	57.345	38.500	0.554	1.00	28.64
ATOM	223	N	LEU A	58	56.653	38.763	−1.567	1.00	26.64
ATOM	224	CA	LEU A	58	57.543	39.887	−1.828	1.00	26.14
ATOM	225	CB	LEU A	58	57.484	40.268	−3.310	1.00	29.02
ATOM	226	CG	LEU A	58	58.480	41.323	−3.798	1.00	31.41
ATOM	227	CD1	LEU A	58	59.896	40.765	−3.693	1.00	32.43
ATOM	228	CD2	LEU A	58	58.167	41.709	−5.237	1.00	32.16
ATOM	229	C	LEU A	58	57.086	41.070	−0.971	1.00	25.90
ATOM	230	O	LEU A	58	57.903	41.836	−0.454	1.00	24.40
ATOM	231	N	ALA A	59	55.769	41.205	−0.832	1.00	24.36
ATOM	232	CA	ALA A	59	55.166	42.275	−0.042	1.00	23.05
ATOM	233	CB	ALA A	59	53.641	42.159	−0.074	1.00	20.54
ATOM	234	C	ALA A	59	55.651	42.188	1.391	1.00	20.64
ATOM	235	O	ALA A	59	56.037	43.190	1.992	1.00	21.25
ATOM	236	N	VAL A	60	55.612	40.982	1.941	1.00	20.09
ATOM	237	CA	VAL A	60	56.056	40.766	3.308	1.00	19.99
ATOM	238	CB	VAL A	60	55.817	39.300	3.741	1.00	18.43
ATOM	239	CG1	VAL A	60	56.407	39.054	5.129	1.00	17.76
ATOM	240	CG2	VAL A	60	54.324	39.003	3.742	1.00	14.72
ATOM	241	C	VAL A	60	57.541	41.111	3.425	1.00	21.05
ATOM	242	O	VAL A	60	57.951	41.785	4.365	1.00	21.13
ATOM	243	N	ARG A	61	58.340	40.664	2.459	1.00	23.89
ATOM	244	CA	ARG A	61	59.776	40.944	2.471	1.00	27.66
ATOM	245	CB	ARG A	61	60.469	40.352	1.239	1.00	29.95
ATOM	246	CG	ARG A	61	60.426	38.838	1.122	1.00	38.36
ATOM	247	CD	ARG A	61	61.548	38.355	0.196	1.00	44.69
ATOM	248	NE	ARG A	61	61.477	36.926	−0.101	1.00	50.18
ATOM	249	CZ	ARG A	61	60.671	36.388	−1.014	1.00	51.97
ATOM	250	NH1	ARG A	61	59.863	37.159	−1.729	1.00	51.92
ATOM	251	NH2	ARG A	61	60.674	35.076	−1.212	1.00	53.20
ATOM	252	C	ARG A	61	60.065	42.443	2.510	1.00	27.16
ATOM	253	O	ARG A	61	60.778	42.925	3.392	1.00	25.78
ATOM	254	N	PHE A	62	59.514	43.175	1.546	1.00	26.45
ATOM	255	CA	PHE A	62	59.737	44.611	1.470	1.00	28.86
ATOM	256	CB	PHE A	62	59.039	45.194	−0.239	1.00	31.67
ATOM	257	CG	PHE A	62	59.842	45.074	−1.024	1.00	35.37
ATOM	258	CD1	PHE A	62	60.354	43.852	−1.424	1.00	36.62
ATOM	259	CD2	PHE A	62	60.081	46.186	−1.816	1.00	38.91
ATOM	260	CE1	PHE A	62	61.089	43.739	−2.591	1.00	38.37
ATOM	261	CE2	PHE A	62	60.816	46.079	−2.986	1.00	40.05
ATOM	262	CZ	PHE A	62	61.320	44.853	−3.373	1.00	39.06
ATOM	263	C	PHE A	62	59.277	45.345	2.717	1.00	28.84
ATOM	264	O	PHE A	62	59.950	46.265	3.184	1.00	28.63
ATOM	265	N	THR A	63	58.131	44.941	3.252	1.00	28.32
ATOM	266	CA	THR A	63	57.598	45.576	4.446	1.00	27.37
ATOM	267	CB	THR A	63	56.196	45.023	4.798	1.00	26.41
ATOM	268	OG1	THR A	63	55.298	45.267	3.709	1.00	24.23
ATOM	269	CG2	THR A	63	55.653	45.700	6.044	1.00	25.26
ATOM	270	C	THR A	63	58.537	45.351	5.626	1.00	28.52
ATOM	271	O	THR A	63	58.851	46.284	6.369	1.00	27.19
ATOM	272	N	SER A	64	58.991	44.112	5.793	1.00	28.48
ATOM	273	CA	SER A	64	59.890	43.790	6.895	1.00	30.95
ATOM	274	CB	SER A	64	60.206	42.291	6.909	1.00	30.12
ATOM	275	OG	SER A	64	60.986	41.918	5.787	1.00	34.09
ATOM	276	C	SER A	64	61.186	44.592	6.791	1.00	31.50
ATOM	277	O	SER A	64	61.789	44.940	7.803	1.00	31.30
ATOM	278	N	LEU A	65	61.603	44.893	5.565	1.00	33.16
ATOM	279	CA	LEU A	65	62.830	45.654	5.343	1.00	34.16
ATOM	280	CB	LEU A	65	63.497	45.212	4.035	1.00	33.74
ATOM	281	CG	LEU A	65	63.989	43.762	3.999	1.00	36.53
ATOM	282	CD1	LEU A	65	64.580	43.449	2.636	1.00	34.22
ATOM	283	CD2	LEU A	65	65.026	43.543	5.098	1.00	36.82
ATOM	284	C	LEU A	65	62.599	47.165	5.320	1.00	34.01
ATOM	285	O	LEU A	65	63.543	47.939	5.177	1.00	34.34
ATOM	286	N	GLY A	66	61.345	47.582	5.457	1.00	33.51
ATOM	287	CA	GLY A	66	61.041	49.002	5.463	1.00	34.57
ATOM	288	C	GLY A	66	61.063	49.698	4.110	1.00	35.92
ATOM	289	O	GLY A	66	61.089	50.930	4.044	1.00	35.49
ATOM	290	N	LEU A	67	61.056	48.924	3.030	1.00	36.20
ATOM	291	CA	LEU A	67	61.062	49.500	1.689	1.00	37.47
ATOM	292	CB	LEU A	67	61.477	48.439	0.665	1.00	39.14
ATOM	293	CG	LEU A	67	62.785	47.701	0.982	1.00	41.61
ATOM	294	CD1	LEU A	67	63.070	46.664	−0.092	1.00	41.43
ATOM	295	CD2	LEU A	67	63.931	48.701	1.077	1.00	43.31
ATOM	296	C	LEU A	67	59.647	49.992	1.400	1.00	36.88
ATOM	297	O	LEU A	67	58.908	49.377	0.635	1.00	36.23
ATOM	298	N	LEU A	68	59.281	51.106	2.024	1.00	37.29
ATOM	299	CA	LEU A	68	57.947	51.677	1.881	1.00	38.19
ATOM	300	CB	LEU A	68	57.206	51.575	3.215	1.00	38.57
ATOM	301	CG	LEU A	68	57.206	50.198	3.878	1.00	39.38
ATOM	302	CD1	LEU A	68	56.690	50.310	5.299	1.00	39.44
ATOM	303	CD2	LEU A	68	56.356	49.244	3.059	1.00	40.05
ATOM	304	C	LEU A	68	57.983	53.137	1.449	1.00	38.35
ATOM	305	O	LEU A	68	58.922	53.865	1.764	1.00	38.77
ATOM	306	N	PRO A	69	56.945	53.583	0.726	1.00	38.45
ATOM	307	CD	PRO A	69	55.780	52.778	0.323	1.00	37.87
ATOM	308	CA	PRO A	69	56.819	54.956	0.232	1.00	39.07
ATOM	309	CB	PRO A	69	55.580	54.885	−0.657	1.00	38.36
ATOM	310	CG	PRO A	69	54.754	53.842	0.012	1.00	38.12
ATOM	311	C	PRO A	69	56.666	55.976	1.358	1.00	39.55
ATOM	312	O	PRO A	69	56.798	55.640	2.535	1.00	40.34
ATOM	313	N	PHE A	73	51.509	61.626	6.239	1.00	57.41
ATOM	314	CA	PHE A	73	50.304	61.905	7.014	1.00	57.56
ATOM	315	CB	PHE A	73	49.146	61.013	6.554	1.00	57.94
ATOM	316	CG	PHE A	73	47.896	61.178	7.376	1.00	57.97
ATOM	317	CD1	PHE A	73	47.046	62.252	7.167	1.00	58.09
ATOM	318	CD2	PHE A	73	47.592	60.279	8.388	1.00	58.00
ATOM	319	CE1	PHE A	73	45.918	62.427	7.950	1.00	57.86
ATOM	320	CE2	PHE A	73	46.465	60.451	9.175	1.00	56.97
ATOM	321	CZ	PHE A	73	45.628	61.525	8.956	1.00	56.70
ATOM	322	C	PHE A	73	50.519	61.683	8.506	1.00	56.61
ATOM	323	O	PHE A	73	50.884	60.586	8.932	1.00	56.50
ATOM	324	N	GLN A	74	50.289	62.727	9.295	1.00	55.80
ATOM	325	CA	GLN A	74	50.434	62.632	10.743	1.00	54.27
ATOM	326	CB	GLN A	74	51.067	63.902	11.316	1.00	55.72
ATOM	327	CG	GLN A	74	52.551	64.063	11.029	1.00	58.53
ATOM	328	CD	GLN A	74	53.176	65.195	11.835	1.00	60.58
ATOM	329	OE1	GLN A	74	52.868	66.371	11.625	1.00	60.54
ATOM	330	NE2	GLN A	74	54.050	64.839	12.770	1.00	60.75
ATOM	331	C	GLN A	74	49.061	62.429	11.366	1.00	51.91
ATOM	332	O	GLN A	74	48.107	63.128	11.029	1.00	51.26
ATOM	333	N	ASP A	75	48.965	61.464	12.271	1.00	49.71
ATOM	334	CA	ASP A	75	47.705	61.173	12.940	1.00	47.29
ATOM	335	CB	ASP A	75	47.826	59.868	13.733	1.00	46.43
ATOM	336	CG	ASP A	75	48.173	58.681	12.853	1.00	44.45
ATOM	337	OD1	ASP A	75	48.650	57.657	13.391	1.00	41.73
ATOM	338	OD2	ASP A	75	47.960	58.771	11.626	1.00	44.21
ATOM	339	C	ASP A	75	47.359	62.319	13.884	1.00	46.48
ATOM	340	O	ASP A	75	48.217	62.803	14.622	1.00	46.43
ATOM	341	N	SER A	76	46.106	62.757	13.853	1.00	45.52
ATOM	342	CA	SER A	76	45.666	63.839	14.726	1.00	43.83
ATOM	343	CB	SER A	76	44.732	64.791	13.976	1.00	43.83
ATOM	344	OG	SER A	76	43.519	64.147	13.630	1.00	45.56
ATOM	345	C	SER A	76	44.935	63.239	15.916	1.00	42.06
ATOM	346	O	SER A	76	44.492	62.094	15.866	1.00	42.96
ATOM	347	N	ASP A	77	44.814	64.014	16.985	1.00	40.79
ATOM	348	CA	ASP A	77	44.131	63.558	18.188	1.00	40.57
ATOM	349	CB	ASP A	77	43.969	64.725	19.167	1.00	42.86
ATOM	350	CG	ASP A	77	45.303	65.296	19.620	1.00	46.39
ATOM	351	OD1	ASP A	77	45.301	66.339	20.307	1.00	48.20
ATOM	352	OD2	ASP A	77	46.354	64.702	19.294	1.00	47.94
ATOM	353	C	ASP A	77	42.761	62.959	17.866	1.00	38.52
ATOM	354	O	ASP A	77	42.285	62.070	18.568	1.00	37.86
ATOM	355	N	MET A	78	42.137	63.451	16.799	1.00	37.07
ATOM	356	CA	MET A	78	40.819	62.976	16.376	1.00	35.68
ATOM	357	CB	MET A	78	40.371	63.700	15.105	1.00	36.68
ATOM	358	CG	MET A	78	40.022	65.154	15.279	1.00	38.98
ATOM	359	SD	MET A	78	39.373	65.811	13.731	1.00	43.55
ATOM	360	CE	MET A	78	37.673	65.195	13.798	1.00	40.05
ATOM	361	C	MET A	78	40.758	61.476	16.104	1.00	33.08
ATOM	362	O	MET A	78	39.758	60.823	16.405	1.00	32.55
ATOM	363	N	LEU A	79	41.823	60.937	15.521	1.00	29.66
ATOM	364	CA	LEU A	79	41.861	59.523	15.186	1.00	28.85
ATOM	365	CB	LEU A	79	42.852	59.286	14.043	1.00	26.36
ATOM	366	CG	LEU A	79	42.531	60.008	12.728	1.00	27.00
ATOM	367	CD1	LEU A	79	43.494	59.545	11.640	1.00	24.52
ATOM	368	CD2	LEU A	79	41.090	59.723	12.316	1.00	23.83
ATOM	369	C	LEU A	79	42.197	58.611	16.359	1.00	28.62
ATOM	370	O	LEU A	79	42.120	57.387	16.237	1.00	27.51
ATOM	371	N	GLU A	80	42.558	59.199	17.495	1.00	27.92
ATOM	372	CA	GLU A	80	42.905	58.408	18.666	1.00	28.74
ATOM	373	CB	GLU A	80	43.609	59.272	19.717	1.00	30.72
ATOM	374	CG	GLU A	80	43.731	58.592	21.078	1.00	36.88
ATOM	375	CD	GLU A	80	44.634	59.344	22.045	1.00	40.61
ATOM	376	OE1	GLU A	80	44.556	59.070	23.262	1.00	40.98
ATOM	377	OE2	GLU A	80	45.427	60.199	21.591	1.00	43.20
ATOM	378	C	GLU A	80	41.686	57.743	19.286	1.00	28.29
ATOM	379	O	GLU A	80	40.633	58.357	19.432	1.00	29.91
ATOM	380	N	VAL A	81	41.841	56.478	19.649	1.00	26.82
ATOM	381	CA	VAL A	81	40.762	55.717	20.255	1.00	27.29
ATOM	382	CB	VAL A	81	40.157	54.697	19.253	1.00	27.96
ATOM	383	CG1	VAL A	81	38.975	53.978	19.891	1.00	26.13
ATOM	384	CG2	VAL A	81	39.736	55.401	17.976	1.00	27.50
ATOM	385	C	VAL A	81	41.306	54.939	21.441	1.00	27.37
ATOM	386	O	VAL A	81	42.470	54.529	21.445	1.00	27.61
ATOM	387	N	ARG A	82	40.468	54.738	22.450	1.00	27.98
ATOM	388	CA	ARG A	82	40.887	53.977	23.615	1.00	29.54
ATOM	389	CB	ARG A	82	40.957	54.860	24.862	1.00	32.27
ATOM	390	CG	ARG A	82	42.033	54.387	25.823	1.00	39.97
ATOM	391	CD	ARG A	82	41.640	54.494	27.289	1.00	45.20
ATOM	392	NE	ARG A	82	42.662	53.886	28.145	1.00	48.67
ATOM	393	CZ	ARG A	82	43.059	52.618	28.050	1.00	48.74
ATOM	394	NH1	ARG A	82	42.523	51.816	27.139	1.00	49.38
ATOM	395	NH2	ARG A	82	43.999	52.153	28.859	1.00	50.09
ATOM	396	C	ARG A	82	39.912	52.836	23.853	1.00	28.48
ATOM	397	O	ARG A	82	38.738	53.064	24.133	1.00	29.58
ATOM	398	N	VAL A	83	40.408	51.609	23.729	1.00	28.50
ATOM	399	CA	VAL A	83	39.604	50.406	23.930	1.00	28.91
ATOM	400	CB	VAL A	83	38.780	50.041	22.673	1.00	29.46
ATOM	401	CG1	VAL A	83	37.530	50.896	22.597	1.00	31.26
ATOM	402	CG2	VAL A	83	39.633	50.220	21.423	1.00	25.10
ATOM	403	C	VAL A	83	40.493	49.216	24.245	1.00	29.96
ATOM	404	O	VAL A	83	41.710	49.284	24.086	1.00	29.44
ATOM	405	N	LEU A	84	39.873	48.124	24.688	1.00	31.71
ATOM	406	CA	LEU A	84	40.596	46.896	25.005	1.00	32.74
ATOM	407	CB	LEU A	84	41.132	46.263	23.712	1.00	31.47
ATOM	408	CG	LEU A	84	40.080	46.012	22.622	1.00	31.62
ATOM	409	CD1	LEU A	84	40.753	45.558	21.343	1.00	31.18
ATOM	410	CD2	LEU A	84	39.079	44.976	23.103	1.00	27.96
ATOM	411	C	LEU A	84	41.752	47.136	25.973	1.00	33.44
ATOM	412	O	LEU A	84	42.748	46.413	25.946	1.00	35.00
ATOM	413	N	GLY A	85	41.613	48.151	26.824	1.00	33.39
ATOM	414	CA	GLY A	85	42.654	48.466	27.790	1.00	31.80
ATOM	415	C	GLY A	85	43.896	49.059	27.148	1.00	31.85
ATOM	416	O	GLY A	85	44.998	48.962	27.694	1.00	30.17
ATOM	417	N	HIS A	86	43.718	49.683	25.988	1.00	31.24
ATOM	418	CA	HIS A	86	44.836	50.281	25.271	1.00	31.52
ATOM	419	CB	HIS A	86	45.423	49.271	24.275	1.00	33.75
ATOM	420	CG	HIS A	86	45.969	48.034	24.915	1.00	36.55
ATOM	421	CD2	HIS A	86	45.508	46.760	24.931	1.00	37.53
ATOM	422	ND1	HIS A	86	47.121	48.033	25.672	1.00	37.68
ATOM	423	CE1	HIS A	86	47.346	46.814	26.128	1.00	37.36
ATOM	424	NE2	HIS A	86	46.381	46.022	25.693	1.00	39.46
ATOM	425	C	HIS A	86	44.453	51.546	24.511	1.00	30.30
ATOM	426	O	HIS A	86	43.280	51.835	24.280	1.00	29.95
ATOM	427	N	LYS A	87	45.471	52.297	24.122	1.00	29.57
ATOM	428	CA	LYS A	87	45.272	53.512	23.357	1.00	28.75
ATOM	429	CB	LYS A	87	46.130	54.643	23.928	1.00	31.29
ATOM	430	CG	LYS A	87	46.065	55.930	23.131	1.00	36.25
ATOM	431	CD	LYS A	87	46.998	56.986	23.704	1.00	39.73
ATOM	432	CB	LYS A	87	48.452	56.557	23.603	1.00	41.38
ATOM	433	NZ	LYS A	87	49.372	57.604	24.134	1.00	43.32
ATOM	434	C	LYS A	87	45.710	53.199	21.931	1.00	26.30
ATOM	435	O	LYS A	87	46.724	52.525	21.724	1.00	24.62
ATOM	436	N	PHE A	88	44.928	53.657	20.958	1.00	22.40
ATOM	437	CA	PHE A	88	45.251	53.453	19.549	1.00	21.04
ATOM	438	CB	PHE A	88	44.151	52.648	18.845	1.00	17.91
ATOM	439	CG	PHE A	88	43.990	51.239	19.358	1.00	16.58
ATOM	440	CD1	PHE A	88	43.489	50.995	20.628	1.00	15.22
ATOM	441	CD2	PHE A	88	44.321	50.157	18.555	1.00	13.45
ATOM	442	CE1	PHE A	88	43.317	49.703	21.087	1.00	15.04
ATOM	443	CE2	PHE A	88	44.153	48.866	19.007	1.00	13.65
ATOM	444	CZ	PHE A	88	43.650	48.636	20.275	1.00	15.42
ATOM	445	C	PHE A	88	45.350	54.841	18.917	1.00	21.32
ATOM	446	O	PHE A	88	44.363	55.578	18.900	1.00	21.11
ATOM	447	N	ARG A	89	46.524	55.203	18.399	1.00	21.70
ATOM	448	CA	ARG A	89	46.681	56.526	17.797	1.00	23.91
ATOM	449	CB	ARG A	89	48.142	56.803	17.422	1.00	27.51
ATOM	450	CG	ARG A	89	48.735	55.905	16.369	1.00	34.45
ATOM	451	CD	ARG A	89	50.095	56.441	15.949	1.00	39.63
ATOM	452	NE	ARG A	89	50.942	56.726	17.103	1.00	43.01
ATOM	453	CZ	ARG A	89	52.223	57.073	17.025	1.00	45.72
ATOM	454	NH1	ARG A	89	52.814	57.180	15.840	1.00	45.78
ATOM	455	NH2	ARG A	89	52.915	57.309	18.133	1.00	46.24
ATOM	456	C	ARG A	89	45.764	56.722	16.593	1.00	21.40
ATOM	457	O	ARG A	89	45.350	57.839	16.308	1.00	20.59
ATOM	458	N	ASN A	90	45.467	55.643	15.877	1.00	19.60
ATOM	459	CA	ASN A	90	44.525	55.708	14.759	1.00	19.44
ATOM	460	CB	ASN A	90	45.218	56.045	13.418	1.00	17.27
ATOM	461	CG	ASN A	90	45.918	54.870	12.782	1.00	17.47
ATOM	462	OD1	ASN A	90	45.286	53.885	12.404	1.00	18.85
ATOM	463	ND2	ASN A	90	47.236	54.977	12.635	1.00	17.61
ATOM	464	C	ASN A	90	43.814	54.357	14.762	1.00	19.17
ATOM	465	O	ASN A	90	44.377	53.351	15.199	1.00	20.42
ATOM	466	N	PRO A	91	42.555	54.325	14.307	1.00	17.95
ATOM	467	CD	PRO A	91	41.802	55.495	13.815	1.00	18.80
ATOM	468	CA	PRO A	91	41.721	53.123	14.259	1.00	17.08
ATOM	469	CB	PRO A	91	40.319	53.708	14.339	1.00	17.82
ATOM	470	CG	PRO A	91	40.444	54.896	13.443	1.00	15.11
ATOM	471	C	PRO A	91	41.872	52.197	13.059	1.00	17.57
ATOM	472	O	PRO A	91	41.071	51.277	12.889	1.00	17.10
ATOM	473	N	VAL A	92	42.889	52.425	12.236	1.00	17.30
ATOM	474	CA	VAL A	92	43.086	51.607	11.040	1.00	17.64
ATOM	475	CB	VAL A	92	43.391	52.504	9.816	1.00	17.72
ATOM	476	CG1	VAL A	92	43.497	51.666	8.555	1.00	14.42
ATOM	477	CG2	VAL A	92	42.310	53.560	9.678	1.00	16.61
ATOM	478	C	VAL A	92	44.206	50.588	11.201	1.00	18.02
ATOM	479	O	VAL A	92	45.377	50.948	11.280	1.00	18.29
ATOM	480	N	GLY A	93	43.840	49.311	11.242	1.00	17.60
ATOM	481	CA	GLY A	93	44.839	48.274	11.394	1.00	16.36
ATOM	482	C	GLY A	93	44.907	47.332	10.212	1.00	16.58
ATOM	483	O	GLY A	93	44.043	47.352	9.336	1.00	17.37
ATOM	484	N	ILE A	94	45.956	46.517	10.174	1.00	16.03
ATOM	485	CA	ILE A	94	46.123	45.541	9.106	1.00	14.28
ATOM	486	CB	ILE A	94	47.621	45.319	8.772	1.00	15.21
ATOM	487	CG2	ILE A	94	48.409	45.008	10.035	1.00	14.14
ATOM	488	CG1	ILE A	94	47.766	44.197	7.740	1.00	15.27
ATOM	489	CD1	ILE A	94	47.288	44.580	6.347	1.00	15.14
ATOM	490	C	ILE A	94	45.494	44.236	9.595	1.00	14.89
ATOM	491	O	ILE A	94	45.868	43.707	10.639	1.00	14.26
ATOM	492	N	ALA A	95	44.521	43.729	8.847	1.00	14.41
ATOM	493	CA	ALA A	95	43.837	42.501	9.228	1.00	14.87
ATOM	494	CB	ALA A	95	42.665	42.244	8.282	1.00	14.00
ATOM	495	C	ALA A	95	44.770	41.292	9.248	1.00	14.88
ATOM	496	O	ALA A	95	45.877	41.338	8.715	1.00	13.34
ATOM	497	N	ALA A	96	44.314	40.215	9.878	1.00	14.32
ATOM	498	CA	ALA A	96	45.092	38.989	9.952	1.00	17.35
ATOM	499	CB	ALA A	96	44.392	37.976	10.856	1.00	16.42
ATOM	500	C	ALA A	96	45.240	38.419	8.546	1.00	17.48
ATOM	501	O	ALA A	96	44.386	38.641	7.686	1.00	19.61
ATOM	502	N	GLY A	97	46.326	37.691	8.309	1.00	18.20
ATOM	503	CA	GLY A	97	46.534	37.106	6.997	1.00	16.78
ATOM	504	C	GLY A	97	47.697	37.681	6.214	1.00	15.75
ATOM	505	O	GLY A	97	48.411	36.937	5.551	1.00	16.02
ATOM	506	N	PHE A	98	47.894	38.995	6.266	1.00	15.54
ATOM	507	CA	PHE A	98	49.006	39.586	5.533	1.00	16.58
ATOM	508	CB	PHE A	98	48.955	41.115	5.550	1.00	16.83
ATOM	509	CG	PHE A	98	50.097	41.747	4.815	1.00	18.26
ATOM	510	CD1	PHE A	98	50.166	41.680	3.429	1.00	19.90
ATOM	511	CD2	PHE A	98	51.139	42.346	5.505	1.00	19.00
ATOM	512	CE1	PHE A	98	51.254	42.193	2.748	1.00	19.02
ATOM	513	CE2	PHE A	98	52.233	42.863	4.831	1.00	18.84
ATOM	514	CZ	PHE A	98	52.291	42.786	3.451	1.00	20.99
ATOM	515	C	PHE A	98	50.315	39.127	6.164	1.00	15.86
ATOM	516	O	PHE A	98	51.200	38.620	5.482	1.00	15.58
ATOM	517	N	ASP A	99	50.433	39.322	7.472	1.00	16.10
ATOM	518	CA	ASP A	99	51.626	38.905	8.203	1.00	15.76
ATOM	519	CB	ASP A	99	52.158	40.070	9.040	1.00	15.13
ATOM	520	CG	ASP A	99	53.540	39.802	9.610	1.00	18.19
ATOM	521	OD1	ASP A	99	54.167	38.794	9.224	1.00	17.29
ATOM	522	OD2	ASP A	99	54.006	40.612	10.439	1.00	19.53
ATOM	523	C	ASP A	99	51.228	37.729	9.101	1.00	16.25
ATOM	524	O	ASP A	99	50.995	37.894	10.300	1.00	14.46
ATOM	525	N	LYS A	100	51.134	36.546	8.499	1.00	16.78
ATOM	526	CA	LYS A	100	50.750	35.335	9.215	1.00	17.78
ATOM	527	CB	LYS A	100	50.484	34.194	8.222	1.00	19.95
ATOM	528	CG	LYS A	100	49.149	34.250	7.478	1.00	21.28
ATOM	529	CD	LYS A	100	49.084	33.139	6.426	1.00	24.43
ATOM	530	CB	LYS A	100	47.727	33.060	5.714	1.00	25.79
ATOM	531	NZ	LYS A	100	46.644	32.486	6.578	1.00	23.81
ATOM	532	C	LYS A	100	51.767	34.849	10.247	1.00	18.87
ATOM	533	O	LYS A	100	51.389	34.269	11.267	1.00	19.75
ATOM	534	N	HIS A	101	53.050	35.083	9.993	1.00	18.22
ATOM	535	CA	HIS A	101	54.088	34.601	10.902	1.00	20.19
ATOM	536	CB	HIS A	101	55.109	33.779	10.106	1.00	17.78
ATOM	537	CG	HIS A	101	54.507	33.029	8.959	1.00	18.92
ATOM	538	CD2	HIS A	101	54.760	33.081	7.629	1.00	17.74
ATOM	539	ND1	HIS A	101	53.491	32.110	9.120	1.00	18.19
ATOM	540	CE1	HIS A	101	53.145	31.629	7.938	1.00	17.82
ATOM	541	NE2	HIS A	101	53.899	32.202	7.017	1.00	17.25
ATOM	542	C	HIS A	101	54.818	35.677	11.705	1.00	20.40
ATOM	543	O	HIS A	101	55.859	35.403	12.299	1.00	22.15
ATOM	544	N	GLY A	102	54.277	36.892	11.718	1.00	21.38
ATOM	545	CA	GLY A	102	54.896	37.979	12.460	1.00	21.06
ATOM	546	C	GLY A	102	56.275	38.379	11.969	1.00	20.98
ATOM	547	O	GLY A	102	57.179	38.593	12.768	1.00	22.33
ATOM	548	N	GLU A	103	56.435	38.503	10.656	1.00	22.97
ATOM	549	CA	GLU A	103	57.723	38.867	10.062	1.00	22.35
ATOM	550	CB	GLU A	103	57.952	38.059	8.787	1.00	21.09
ATOM	551	CG	GLU A	103	58.004	36.564	8.992	1.00	24.78
ATOM	552	CD	GLU A	103	58.049	35.808	7.683	1.00	26.81
ATOM	553	OE1	GLU A	103	57.014	35.763	6.980	1.00	26.94
ATOM	554	OE2	GLU A	103	59.125	35.266	7.353	1.00	29.11
ATOM	555	C	GLU A	103	57.883	40.342	9.713	1.00	21.88
ATOM	556	O	GLU A	103	58.999	40.806	9.500	1.00	22.98
ATOM	557	N	ALA A	104	56.784	41.084	9.651	1.00	21.38
ATOM	558	CA	ALA A	104	56.870	42.491	9.269	1.00	20.31
ATOM	559	CB	ALA A	104	56.378	42.650	7.841	1.00	17.37
ATOM	560	C	ALA A	104	56.116	43.451	10.175	1.00	19.53
ATOM	561	O	ALA A	104	55.704	44.523	9.738	1.00	18.99
ATOM	562	N	VAL A	105	55.945	43.079	11.436	1.00	19.90
ATOM	563	CA	VAL A	105	55.216	43.924	12.375	1.00	19.69
ATOM	564	CB	VAL A	105	55.345	43.387	13.808	1.00	19.43
ATOM	565	CG1	VAL A	105	54.673	44.339	14.779	1.00	17.75
ATOM	566	CG2	VAL A	105	54.725	41.997	13.892	1.00	17.02
ATOM	567	C	VAL A	105	55.660	45.386	12.361	1.00	20.42
ATOM	568	O	VAL A	105	54.831	46.293	12.260	1.00	21.86
ATOM	569	N	ASP A	106	56.965	45.615	12.454	1.00	18.26
ATOM	570	CA	ASP A	106	57.489	46.975	12.472	1.00	19.05
ATOM	571	CB	ASP A	106	58.962	46.960	12.888	1.00	18.62
ATOM	572	CG	ASP A	106	59.144	46.470	14.308	1.00	19.89
ATOM	573	OD1	ASP A	106	59.732	45.383	14.502	1.00	21.15
ATOM	574	OD2	ASP A	106	58.677	47.171	15.231	1.00	19.02
ATOM	575	C	ASP A	106	57.315	47.721	11.158	1.00	18.20
ATOM	576	O	ASP A	106	57.043	48.924	11.154	1.00	18.32
ATOM	577	N	GLY A	107	57.474	47.013	10.048	1.00	15.97
ATOM	578	CA	GLY A	107	57.300	47.645	8.756	1.00	16.89
ATOM	579	C	GLY A	107	55.847	48.039	8.558	1.00	18.68
ATOM	580	O	GLY A	107	55.542	48.944	7.781	1.00	20.07
ATOM	581	N	LEU A	108	54.945	47.361	9.265	1.00	17.60
ATOM	582	CA	LEU A	108	53.519	47.655	9.163	1.00	17.75
ATOM	583	CB	LEU A	108	52.694	46.456	9.649	1.00	18.20
ATOM	584	CG	LEU A	108	52.741	45.283	8.662	1.00	17.32
ATOM	585	CD1	LEU A	108	52.194	44.020	9.297	1.00	15.87
ATOM	586	CD2	LEU A	108	51.954	45.655	7.415	1.00	18.07
ATOM	587	C	LEU A	108	53.150	48.923	9.931	1.00	17.52
ATOM	588	O	LEU A	108	52.326	49.706	9.465	1.00	17.59
ATOM	589	N	TYR A	109	53.747	49.132	11.103	1.00	17.99
ATOM	590	CA	TYR A	109	53.475	50.356	11.863	1.00	19.57
ATOM	591	CB	TYR A	109	54.181	50.346	13.231	1.00	17.67
ATOM	592	CG	TYR A	109	53.572	49.412	14.257	1.00	15.68
ATOM	593	CD1	TYR A	109	54.319	48.386	14.818	1.00	15.06
ATOM	594	CE1	TYR A	109	53.761	47.514	15.739	1.00	16.14
ATOM	595	CD2	TYR A	109	52.244	49.546	14.649	1.00	14.34
ATOM	596	CE2	TYR A	109	51.677	48.681	15.571	1.00	14.45
ATOM	597	CZ	TYR A	109	52.439	47.665	16.110	1.00	16.08
ATOM	598	OH	TYR A	109	51.877	46.785	17.006	1.00	15.83
ATOM	599	C	TYR A	109	54.017	51.522	11.039	1.00	20.38
ATOM	600	O	TYR A	109	53.438	52.610	11.014	1.00	20.47
ATOM	601	N	LYS A	110	55.138	51.285	10.365	1.00	20.32
ATOM	602	CA	LYS A	110	55.761	52.310	9.542	1.00	22.38
ATOM	603	CB	LYS A	110	57.145	51.851	9.077	1.00	22.88
ATOM	604	CG	LYS A	110	57.824	52.849	8.162	1.00	26.65
ATOM	605	CD	LYS A	110	59.186	52.374	7.706	1.00	30.71
ATOM	606	CB	LYS A	110	59.848	53.417	6.812	1.00	33.71
ATOM	607	NZ	LYS A	110	61.216	53.007	6.386	1.00	37.17
ATOM	608	C	LYS A	110	54.900	52.651	8.327	1.00	22.82
ATOM	609	O	LYS A	110	55.035	53.729	7.742	1.00	21.86
ATOM	610	N	MET A	111	54.020	51.726	7.953	1.00	22.62
ATOM	611	CA	MET A	111	53.134	51.921	6.810	1.00	21.33
ATOM	612	CB	MET A	111	52.596	50.568	6.330	1.00	22.37
ATOM	613	CG	MET A	111	52.116	50.555	4.883	1.00	23.26
ATOM	614	SD	MET A	111	51.647	48.908	4.295	1.00	22.91
ATOM	615	CB	MET A	111	53.239	48.159	4.039	1.00	22.34
ATOM	616	C	MET A	111	51.979	52.849	7.198	1.00	21.50
ATOM	617	O	MET A	111	51.237	53.332	6.341	1.00	21.61
ATOM	618	N	GLY A	112	51.829	53.095	8.497	1.00	20.35
ATOM	619	CA	GLY A	112	50.774	53.981	8.954	1.00	18.20
ATOM	620	C	GLY A	112	49.652	53.346	9.754	1.00	17.70
ATOM	621	O	GLY A	112	48.757	54.049	10.222	1.00	18.34
ATOM	622	N	PHE A	113	49.687	52.027	9.922	1.00	15.93
ATOM	623	CA	PHE A	113	48.640	51.340	10.676	1.00	15.61
ATOM	624	CB	PHE A	113	48.761	49.824	10.503	1.00	15.10
ATOM	625	CG	PHE A	113	48.390	49.340	9.132	1.00	15.46
ATOM	626	CD1	PHE A	113	49.361	48.889	8.254	1.00	15.32
ATOM	627	CD2	PHE A	113	47.064	49.328	8.724	1.00	15.07
ATOM	628	CE1	PHE A	113	49.017	48.428	6.991	1.00	17.40
ATOM	629	CE2	PHE A	113	46.710	48.870	7.464	1.00	15.20
ATOM	630	CZ	PHE A	113	47.687	48.418	6.596	1.00	16.29
ATOM	631	C	PHE A	113	48.664	51.686	12.157	1.00	14.59
ATOM	632	O	PHE A	113	49.726	51.750	12.768	1.00	15.40
ATOM	633	N	GLY A	114	47.482	51.908	12.726	1.00	13.85
ATOM	634	CA	GLY A	114	47.372	52.246	14.136	1.00	13.80
ATOM	635	C	GLY A	114	47.582	51.040	15.032	1.00	15.27
ATOM	636	O	GLY A	114	47.808	51.175	16.232	1.00	16.43
ATOM	637	N	PHE A	115	47.479	49.850	14.452	1.00	15.37
ATOM	638	CA	PHE A	115	47.692	48.623	15.199	1.00	15.37
ATOM	639	CB	PHE A	115	46.548	48.373	16.197	1.00	15.72
ATOM	640	CG	PHE A	115	45.216	48.075	15.568	1.00	14.48
ATOM	641	CD1	PHE A	115	44.723	46.781	15.547	1.00	13.96
ATOM	642	CD2	PHE A	115	44.431	49.096	15.050	1.00	14.85
ATOM	643	CE1	PHE A	115	43.468	46.505	15.026	1.00	13.14
ATOM	644	CE2	PHE A	115	43.174	48.828	14.526	1.00	14.58
ATOM	645	CZ	PHE A	115	42.694	47.528	14.516	1.00	14.33
ATOM	646	C	PHE A	115	47.865	47.457	14.240	1.00	15.74
ATOM	647	O	PHE A	115	47.335	47.467	13.132	1.00	15.07
ATOM	648	N	VAL A	116	48.636	46.463	14.668	1.00	16.41
ATOM	649	CA	VAL A	116	48.926	45.301	13.844	1.00	15.02
ATOM	650	CB	VAL A	116	50.460	45.168	13.617	1.00	15.50
ATOM	651	CG1	VAL A	116	50.778	43.903	12.810	1.00	11.14
ATOM	652	CG2	VAL A	116	50.992	46.415	12.911	1.00	13.00
ATOM	653	C	VAL A	116	48.422	43.998	14.450	1.00	16.38
ATOM	654	O	VAL A	116	48.447	43.815	15.669	1.00	16.18
ATOM	655	N	GLU A	117	47.957	43.100	13.585	1.00	16.09
ATOM	656	CA	GLU A	117	47.487	41.786	14.007	1.00	17.47
ATOM	657	CB	GLU A	117	45.975	41.659	13.838	1.00	15.90
ATOM	658	CG	GLU A	117	45.431	40.316	14.303	1.00	16.28
ATOM	659	CD	GLU A	117	43.919	40.264	14.271	1.00	17.25
ATOM	660	OE1	GLU A	117	43.365	39.320	13.664	1.00	15.76
ATOM	661	OE2	GLU A	117	43.291	41.171	14.856	1.00	14.09
ATOM	662	C	GLU A	117	48.188	40.778	13.109	1.00	17.93
ATOM	663	O	GLU A	117	48.071	40.850	11.886	1.00	19.54
ATOM	664	N	ILE A	118	48.921	39.840	13.697	1.00	17.75
ATOM	665	CA	ILE A	118	49.626	38.874	12.873	1.00	20.53
ATOM	666	CB	ILE A	118	50.982	38.474	13.503	1.00	18.57
ATOM	667	CG2	ILE A	118	51.865	39.707	13.612	1.00	20.32
ATOM	668	CG1	ILE A	118	50.790	37.870	14.887	1.00	18.39
ATOM	669	CD1	ILE A	118	52.086	37.427	15.508	1.00	18.60
ATOM	670	C	ILE A	118	48.782	37.649	12.554	1.00	21.57
ATOM	671	O	ILE A	118	48.186	37.040	13.441	1.00	19.31
ATOM	672	N	GLY A	119	48.730	37.343	11.255	1.00	26.73
ATOM	673	CA	GLY A	119	47.954	36.242	10.701	1.00	23.17
ATOM	674	C	GLY A	119	47.786	35.075	11.630	1.00	24.76
ATOM	675	O	GLY A	119	48.553	34.929	12.584	1.00	25.45
ATOM	676	N	SER A	120	46.791	34.236	11.348	1.00	22.08
ATOM	677	CA	SER A	120	46.528	33.078	12.191	1.00	20.62
ATOM	678	CB	SER A	120	45.364	32.255	11.634	1.00	20.16
ATOM	679	OG	SER A	120	44.124	32.899	11.883	1.00	19.34
ATOM	680	C	SER A	120	47.746	32.192	12.354	1.00	19.19
ATOM	681	O	SER A	120	48.446	31.888	11.389	1.00	19.88
ATOM	682	N	VAL A	121	47.990	31.786	13.593	1.00	18.69
ATOM	683	CA	VAL A	121	49.112	30.922	13.930	1.00	15.40
ATOM	684	CB	VAL A	121	50.010	31.571	15.016	1.00	15.21
ATOM	685	CG1	VAL A	121	51.319	30.784	15.169	1.00	9.68
ATOM	686	CG2	VAL A	121	50.281	33.032	14.663	1.00	12.28
ATOM	687	C	VAL A	121	48.534	29.624	14.485	1.00	16.35
ATOM	688	O	VAL A	121	47.607	29.646	15.300	1.00	15.33
ATOM	689	N	THR A	122	49.067	28.497	14.028	1.00	15.14
ATOM	690	CA	THR A	122	48.617	27.194	14.495	1.00	16.81
ATOM	691	CB	THR A	122	48.447	26.210	13.308	1.00	16.39
ATOM	692	OG1	THR A	122	49.671	26.118	12.572	1.00	16.99
ATOM	693	CG2	THR A	122	47.351	26.701	12.372	1.00	16.20
ATOM	694	C	THR A	122	49.668	26.680	15.480	1.00	16.05
ATOM	695	O	THR A	122	50.811	27.120	15.446	1.00	17.14
ATOM	696	N	PRO A	123	49.289	25.768	16.390	1.00	17.33
ATOM	697	CD	PRO A	123	47.925	25.295	16.685	1.00	16.88
ATOM	698	CA	PRO A	123	50.249	25.234	17.369	1.00	18.81
ATOM	699	CB	PRO A	123	49.423	24.203	18.128	1.00	17.77
ATOM	700	CG	PRO A	123	48.054	24.837	18.126	1.00	17.60
ATOM	701	C	PRO A	123	51.500	24.634	16.732	1.00	20.92
ATOM	702	O	PRO A	123	52.625	25.008	17.074	1.00	21.41
ATOM	703	N	LYS A	124	51.300	23.700	15.810	1.00	21.70
ATOM	704	CA	LYS A	124	52.413	23.074	15.113	1.00	23.21
ATOM	705	CB	LYS A	124	52.190	21.561	14.967	1.00	26.03
ATOM	706	CG	LYS A	124	51.885	20.840	16.270	1.00	30.90
ATOM	707	CD	LYS A	124	52.954	21.122	17.314	1.00	36.86
ATOM	708	CE	LYS A	124	52.546	20.585	18.679	1.00	41.85
ATOM	709	NZ	LYS A	124	53.576	20.858	19.723	1.00	43.99
ATOM	710	C	LYS A	124	52.482	23.701	13.732	1.00	23.17
ATOM	711	O	LYS A	124	51.500	24.267	13.245	1.00	23.15
ATOM	712	N	PRO A	125	53.651	23.629	13.087	1.00	21.56
ATOM	713	CD	PRO A	125	54.955	23.187	13.617	1.00	21.14
ATOM	714	CA	PRO A	125	53.785	24.204	11.748	1.00	20.21
ATOM	715	CB	PRO A	125	55.288	24.096	11.470	1.00	20.65
ATOM	716	CG	PRO A	125	55.917	24.036	12.842	1.00	19.52
ATOM	717	C	PRO A	125	52.972	23.351	10.766	1.00	19.97
ATOM	718	O	PRO A	125	52.731	22.172	11.016	1.00	18.81
ATOM	719	N	GLN A	126	52.539	23.951	9.664	1.00	19.59
ATOM	720	CA	GLN A	126	51.802	23.224	8.634	1.00	20.28
ATOM	721	CB	GLN A	126	50.354	22.921	9.064	1.00	21.32
ATOM	722	CG	GLN A	126	49.449	24.115	9.324	1.00	20.84
ATOM	723	CD	GLN A	126	47.998	23.694	9.555	1.00	22.01
ATOM	724	OE1	GLN A	126	47.718	22.753	10.309	1.00	19.72
ATOM	725	NE2	GLN A	126	47.070	24.398	8.914	1.00	20.71
ATOM	726	C	GLN A	126	51.840	24.032	7.343	1.00	20.63
ATOM	727	O	GLN A	126	51.800	25.260	7.366	1.00	20.52
ATOM	728	N	GLU A	127	51.932	23.332	6.220	1.00	23.02
ATOM	729	CA	GLU A	127	52.034	23.978	4.917	1.00	26.27
ATOM	730	CB	GLU A	127	52.620	22.989	3.903	1.00	30.03
ATOM	731	CG	GLU A	127	53.967	22.418	4.329	1.00	37.96
ATOM	732	CD	GLU A	127	54.686	21.687	3.208	1.00	43.29
ATOM	733	OE1	GLU A	127	54.069	20.799	2.577	1.00	46.06
ATOM	734	OE2	GLU A	127	55.873	21.998	2.963	1.00	45.91
ATOM	735	C	GLU A	127	50.764	24.596	4.345	1.00	24.39
ATOM	736	O	GLU A	127	50.839	25.493	3.508	1.00	22.88
ATOM	737	N	GLY A	128	49.604	24.131	4.791	1.00	23.27
ATOM	738	CA	GLY A	128	48.365	24.667	4.263	1.00	23.54
ATOM	739	C	GLY A	128	48.014	23.952	2.971	1.00	25.46
ATOM	740	O	GLY A	128	48.638	22.943	2.631	1.00	24.72
ATOM	741	N	ASN A	129	47.021	24.462	2.246	1.00	25.50
ATOM	742	CA	ASN A	129	46.608	23.841	0.992	1.00	25.75
ATOM	743	CB	ASN A	129	45.268	24.412	0.524	1.00	24.81
ATOM	744	CG	ASN A	129	44.126	24.050	1.447	1.00	25.93
ATOM	745	OD1	ASN A	129	44.056	22.927	1.948	1.00	26.55
ATOM	746	ND2	ASN A	129	43.214	24.993	1.666	1.00	21.27
ATOM	747	C	ASN A	129	47.642	24.024	−0.113	1.00	26.24
ATOM	748	O	ASN A	129	48.488	24.915	−0.050	1.00	25.50
ATOM	749	N	PRO A	130	47.587	23.165	−1.140	1.00	26.81
ATOM	750	CD	PRO A	130	46.723	21.973	−1.221	1.00	25.39
ATOM	751	CA	PRO A	130	48.515	23.226	−2.274	1.00	26.99
ATOM	752	CB	PRO A	130	48.284	21.887	−2.978	1.00	26.46
ATOM	753	CG	PRO A	130	46.849	21.581	−2.671	1.00	25.27
ATOM	754	C	PRO A	130	48.227	24.424	−3.180	1.00	28.67
ATOM	755	O	PRO A	130	47.087	24.880	−3.263	1.00	29.58
ATOM	756	N	ARG A	131	49.262	24.931	−3.846	1.00	29.41
ATOM	757	CA	ARG A	131	49.124	26.075	−4.746	1.00	31.07
ATOM	758	CB	ARG A	131	50.482	26.732	−4.998	1.00	32.70
ATOM	759	CG	ARG A	131	51.180	27.354	−3.797	1.00	34.79
ATOM	760	CD	ARG A	131	52.260	28.298	−4.315	1.00	40.39
ATOM	761	NE	ARG A	131	53.147	28.840	−3.287	1.00	45.17
ATOM	762	CZ	ARG A	131	54.017	29.827	−3.508	1.00	45.61
ATOM	763	NH1	ARG A	131	54.107	30.376	−4.714	1.00	44.09
ATOM	764	NH2	ARG A	131	54.802	30.261	−2.529	1.00	45.19
ATOM	765	C	ARG A	131	48.543	25.652	−6.096	1.00	32.15
ATOM	766	O	ARG A	131	48.760	24.530	−6.548	1.00	33.75
ATOM	767	N	PRO A	132	47.800	26.552	−6.764	1.00	30.94
ATOM	768	CD	PRO A	132	47.331	26.344	−8.145	1.00	31.60
ATOM	769	CA	PRO A	132	47.488	27.913	−6.316	1.00	28.61
ATOM	770	CB	PRO A	132	47.078	28.607	−7.612	1.00	29.31
ATOM	771	CG	PRO A	132	46.386	27.513	−8.350	1.00	30.17
ATOM	772	C	PRO A	132	46.375	27.914	−5.268	1.00	25.00
ATOM	773	O	PRO A	132	45.484	27.068	−5.296	1.00	23.59
ATOM	774	N	ARG A	133	46.431	28.869	−4.347	1.00	21.85
ATOM	775	CA	ARG A	133	45.438	28.952	−3.290	1.00	19.55
ATOM	776	CB	ARG A	133	46.013	28.323	−2.017	1.00	21.24
ATOM	777	CG	ARG A	133	47.422	28.794	−1.688	1.00	18.90
ATOM	778	CD	ARG A	133	48.095	27.880	−0.678	1.00	16.85
ATOM	779	NE	ARG A	133	49.426	28.373	−0.334	1.00	17.49
ATOM	780	CZ	ARG A	133	50.196	27.856	0.617	1.00	15.57
ATOM	781	NH1	ARG A	133	51.389	28.377	0.861	1.00	13.29
ATOM	782	NH2	ARG A	133	49.775	26.818	1.323	1.00	15.73
ATOM	783	C	ARG A	133	44.954	30.376	−3.023	1.00	19.32
ATOM	784	O	ARG A	133	44.233	30.627	−2.056	1.00	19.05
ATOM	785	N	VAL A	134	45.357	31.307	−3.882	1.00	18.51
ATOM	786	CA	VAL A	134	44.937	32.700	−3.763	1.00	18.75
ATOM	787	CB	VAL A	134	46.058	33.613	−3.222	1.00	18.82
ATOM	788	CG1	VAL A	134	45.451	34.900	−2.680	1.00	15.57
ATOM	789	CG2	VAL A	134	46.848	32.896	−2.162	1.00	18.29
ATOM	790	C	VAL A	134	44.600	33.157	−5.173	1.00	18.69
ATOM	791	O	VAL A	134	45.294	32.800	−6.119	1.00	20.02
ATOM	792	N	PHE A	135	43.542	33.944	−5.320	1.00	19.00
ATOM	793	CA	PHE A	135	43.146	34.398	−6.643	1.00	17.47
ATOM	794	CB	PHE A	135	42.059	33.476	−7.198	1.00	17.16
ATOM	795	CG	PHE A	135	42.387	32.011	−7.067	1.00	17.50
ATOM	796	CD1	PHE A	135	42.102	31.325	−5.894	1.00	16.24
ATOM	797	CD2	PHE A	135	43.029	31.334	−8.097	1.00	18.52
ATOM	798	CE1	PHE A	135	42.453	29.988	−5.749	1.00	17.65
ATOM	799	CE2	PHE A	135	43.384	29.998	−7.960	1.00	16.80
ATOM	800	CZ	PHE A	135	43.096	29.325	−6.784	1.00	16.83
ATOM	801	C	PHE A	135	42.664	35.841	−6.657	1.00	18.35
ATOM	802	O	PHE A	135	41.996	36.303	−5.729	1.00	17.26
ATOM	803	N	ARG A	136	43.026	36.554	−7.717	1.00	17.14
ATOM	804	CA	ARG A	136	42.628	37.939	−7.874	1.00	17.83
ATOM	805	CB	ARG A	136	43.726	38.754	−8.567	1.00	19.09
ATOM	806	CG	ARG A	136	45.089	38.802	−7.892	1.00	21.68
ATOM	807	CD	ARG A	136	45.990	39.767	−8.661	1.00	23.63
ATOM	808	NE	ARG A	136	47.345	39.863	−8.121	1.00	29.57
ATOM	809	CZ	ARG A	136	48.412	39.256	−8.638	1.00	31.45
ATOM	810	NH1	ARG A	136	49.600	39.408	−8.070	1.00	31.05
ATOM	811	NH2	ARG A	136	48.297	38.504	−9.726	1.00	31.93
ATOM	812	C	ARG A	136	41.375	38.029	−8.739	1.00	17.93
ATOM	813	O	ARG A	136	41.218	37.266	−9.699	1.00	17.19
ATOM	814	N	LEU A	137	40.488	38.953	−8.377	1.00	15.76
ATOM	815	CA	LEU A	137	39.268	39.241	−9.132	1.00	14.78
ATOM	816	CB	LEU A	137	38.006	38.849	−8.359	1.00	15.58
ATOM	817	CG	LEU A	137	37.574	37.378	−8.285	1.00	17.50
ATOM	818	CD1	LEU A	137	38.617	36.547	−7.540	1.00	17.15
ATOM	819	CD2	LEU A	137	36.231	37.301	−7.580	1.00	12.95
ATOM	820	C	LEU A	137	39.324	40.759	−9.273	1.00	15.42
ATOM	821	O	LEU A	137	38.583	41.485	−8.608	1.00	14.16
ATOM	822	N	PRO A	138	40.233	41.258	−10.126	1.00	15.71
ATOM	823	CD	PRO A	138	41.193	40.490	−10.941	1.00	15.13
ATOM	824	CA	PRO A	138	40.389	42.701	−10.338	1.00	16.47
ATOM	825	CB	PRO A	138	41.537	42.789	−11.354	1.00	15.41
ATOM	826	CG	PRO A	138	41.515	41.448	−12.048	1.00	15.79
ATOM	827	C	PRO A	138	39.132	43.456	−10.773	1.00	16.15
ATOM	828	O	PRO A	138	38.948	44.611	−10.399	1.00	16.79
ATOM	829	N	GLU A	139	38.263	42.814	−11.545	1.00	16.16
ATOM	830	CA	GLU A	139	37.037	43.479	−11.981	1.00	17.26
ATOM	831	CB	GLU A	139	36.310	42.648	−13.046	1.00	18.03
ATOM	832	CG	GLU A	139	37.059	42.477	−14.367	1.00	21.85
ATOM	833	CD	GLU A	139	38.073	41.340	−14.348	1.00	24.50
ATOM	834	OE1	GLU A	139	38.713	41.115	−15.397	1.00	27.97
ATOM	835	OE2	GLU A	139	38.234	40.671	−13.300	1.00	23.28
ATOM	836	C	GLU A	139	36.083	43.714	−10.807	1.00	17.84
ATOM	837	O	GLU A	139	35.157	44.522	−10.902	1.00	17.94
ATOM	838	N	ASP A	140	36.308	43.008	−9.702	1.00	14.82
ATOM	839	CA	ASP A	140	35.448	43.132	−8.531	1.00	12.95
ATOM	840	CB	ASP A	140	34.943	41.749	−8.100	1.00	10.76
ATOM	841	CG	ASP A	140	34.317	40.968	−9.245	1.00	13.87
ATOM	842	OD1	ASP A	140	33.260	41.395	−9.756	1.00	12.48
ATOM	843	OD2	ASP A	140	34.882	39.922	−9.635	1.00	14.76
ATOM	844	C	ASP A	140	36.187	43.761	−7.362	1.00	13.94
ATOM	845	O	ASP A	140	35.609	43.956	−6.287	1.00	12.55
ATOM	846	N	GLN A	141	37.460	44.084	−7.574	1.00	14.25
ATOM	847	CA	GLN A	141	38.279	44.639	−6.508	1.00	14.42
ATOM	848	CB	GLN A	141	37.791	46.038	−6.125	1.00	15.62
ATOM	849	CG	GLN A	141	38.168	47.096	−7.160	1.00	22.74
ATOM	850	CD	GLN A	141	37.666	48.493	−6.819	1.00	25.08
ATOM	851	OE1	GLN A	141	37.883	48.998	−5.713	1.00	28.72
ATOM	852	NE2	GLN A	141	37.002	49.130	−7.779	1.00	25.38
ATOM	853	C	GLN A	141	38.157	43.669	−5.336	1.00	14.40
ATOM	854	O	GLN A	141	37.979	44.067	−4.182	1.00	15.04
ATOM	855	N	ALA A	142	38.244	42.380	−5.661	1.00	13.51
ATOM	856	CA	ALA A	142	38.138	41.322	−4.669	1.00	13.56
ATOM	857	CB	ALA A	142	36.775	40.644	−4.780	1.00	11.87
ATOM	858	C	ALA A	142	39.245	40.278	−4.801	1.00	13.69
ATOM	859	O	ALA A	142	39.996	40.255	−5.779	1.00	12.41
ATOM	860	N	VAL A	143	39.328	39.414	−3.795	1.00	13.04
ATOM	861	CA	VAL A	143	40.302	38.337	−3.753	1.00	11.89
ATOM	862	CB	VAL A	143	41.527	38.696	−2.852	1.00	13.64
ATOM	863	CG1	VAL A	143	42.349	37.439	−2.551	1.00	9.11
ATOM	864	CG2	VAL A	143	42.410	39.735	−3.541	1.00	8.79
ATOM	865	C	VAL A	143	39.615	37.112	−3.163	1.00	14.15
ATOM	866	O	VAL A	143	38.687	37.234	−2.364	1.00	16.13
ATOM	867	N	ILE A	144	40.052	35.933	−3.585	1.00	14.22
ATOM	868	CA	ILE A	144	39.522	34.685	−3.057	1.00	13.02
ATOM	869	CB	ILE A	144	38.737	33.883	−4.121	1.00	13.56
ATOM	870	CG2	ILE A	144	38.571	32.429	−3.673	1.00	10.97
ATOM	871	CG1	ILE A	144	37.362	34.519	−4.339	1.00	11.41
ATOM	872	CD1	ILE A	144	36.502	33.760	−5.312	1.00	14.19
ATOM	873	C	ILE A	144	40.744	33.895	−2.630	1.00	13.99
ATOM	874	O	ILE A	144	41.722	33.807	−3.378	1.00	14.68
ATOM	875	N	ASN A	145	40.706	33.334	−1.428	1.00	13.97
ATOM	876	CA	ASN A	145	41.846	32.571	−0.942	1.00	13.60
ATOM	877	CB	ASN A	145	42.716	33.455	−0.040	1.00	13.33
ATOM	878	CG	ASN A	145	42.255	33.447	1.412	1.00	16.34
ATOM	879	OD1	ASN A	145	42.556	32.518	2.163	1.00	14.09
ATOM	880	ND2	ASN A	145	41.510	34.478	1.809	1.00	15.79
ATOM	881	C	ASN A	145	41.426	31.328	−0.170	1.00	14.55
ATOM	882	O	ASN A	145	40.380	31.308	0.485	1.00	13.20
ATOM	883	N	ARG A	146	42.249	30.289	−0.262	1.00	14.22
ATOM	884	CA	ARG A	146	42.011	29.047	0.458	1.00	15.92
ATOM	885	CB	ARG A	146	41.327	28.007	−0.440	1.00	14.93
ATOM	886	CG	ARG A	146	41.972	27.778	−1.797	1.00	14.62
ATOM	887	CD	ARG A	146	41.403	26.513	−2.428	1.00	15.20
ATOM	888	NE	ARG A	146	41.958	26.231	−3.751	1.00	15.82
ATOM	889	CZ	ARG A	146	41.423	26.632	−4.903	1.00	16.69
ATOM	890	NH1	ARG A	146	40.305	27.344	−4.917	1.00	16.41
ATOM	891	NH2	ARG A	146	42.008	26.311	−6.050	1.00	18.44
ATOM	892	C	ARG A	146	43.352	28.519	0.965	1.00	18.18
ATOM	893	O	ARG A	146	43.697	27.355	0.758	1.00	18.08
ATOM	894	N	TYR A	147	44.104	29.394	1.632	1.00	18.01
ATOM	895	CA	TYR A	147	45.410	29.039	2.171	1.00	19.04
ATOM	896	CB	TYR A	147	45.993	30.199	2.979	1.00	18.66
ATOM	897	CG	TYR A	147	46.860	31.121	2.166	1.00	18.81
ATOM	898	CD1	TYR A	147	46.405	32.371	1.774	1.00	19.25
ATOM	899	CE1	TYR A	147	47.196	33.208	1.007	1.00	22.14
ATOM	900	CD2	TYR A	147	48.135	30.728	1.768	1.00	20.06
ATOM	901	CE2	TYR A	147	48.933	31.555	1.000	1.00	21.49
ATOM	902	CZ	TYR A	147	48.458	32.793	0.624	1.00	22.84
ATOM	903	OH	TYR A	147	49.244	33.617	−0.147	1.00	28.55
ATOM	904	C	TYR A	147	45.381	27.795	3.042	1.00	19.59
ATOM	905	O	TYR A	147	46.232	26.917	2.903	1.00	21.39
ATOM	906	N	GLY A	148	44.409	27.732	3.946	1.00	19.48
ATOM	907	CA	GLY A	148	44.288	26.589	4.830	1.00	17.98
ATOM	908	C	GLY A	148	45.183	26.683	6.052	1.00	19.49
ATOM	909	O	GLY A	148	45.692	25.671	6.534	1.00	20.15
ATOM	910	N	PHE A	149	45.389	27.897	6.551	1.00	19.05
ATOM	911	CA	PHE A	149	46.218	28.097	7.738	1.00	19.22
ATOM	912	CB	PHE A	149	45.632	27.334	8.935	1.00	18.23
ATOM	913	CG	PHE A	149	44.456	28.009	9.586	1.00	19.24
ATOM	914	CD1	PHE A	149	43.609	27.289	10.423	1.00	20.94
ATOM	915	CD2	PHE A	149	44.203	29.354	9.386	1.00	20.56
ATOM	916	CE1	PHE A	149	42.529	27.903	11.046	1.00	22.07
ATOM	917	CE2	PHE A	149	43.124	29.976	10.007	1.00	21.74
ATOM	918	CZ	PHE A	149	42.286	29.251	10.836	1.00	21.98
ATOM	919	C	PHE A	149	47.678	27.673	7.569	1.00	19.04
ATOM	920	O	PHE A	149	48.191	26.895	8.370	1.00	20.36
ATOM	921	N	ASN A	150	48.346	28.150	6.527	1.00	17.55
ATOM	922	CA	ASN A	150	49.753	27.821	6.369	1.00	18.25
ATOM	923	CB	ASN A	150	50.277	28.309	5.013	1.00	16.65
ATOM	924	CG	ASN A	150	49.959	29.768	4.752	1.00	18.63
ATOM	925	OD1	ASN A	150	48.805	30.191	4.846	1.00	18.40
ATOM	926	ND2	ASN A	150	50.981	30.544	4.409	1.00	17.11
ATOM	927	C	ASN A	150	50.389	28.597	7.524	1.00	19.71
ATOM	928	O	ASN A	150	50.140	29.793	7.676	1.00	20.26
ATOM	929	N	SER A	151	51.188	27.925	8.346	1.00	18.09
ATOM	930	CA	SER A	151	51.781	28.589	9.498	1.00	18.68
ATOM	931	CB	SER A	151	50.775	28.556	10.655	1.00	17.80
ATOM	932	OG	SER A	151	51.372	28.931	11.883	1.00	16.50
ATOM	933	C	SER A	151	53.117	28.017	9.974	1.00	19.15
ATOM	934	O	SER A	151	53.339	26.802	9.931	1.00	18.28
ATOM	935	N	HIS A	152	53.992	28.911	10.438	1.00	18.31
ATOM	936	CA	HIS A	152	55.307	28.532	10.956	1.00	18.93
ATOM	937	CB	HIS A	152	56.217	29.762	11.083	1.00	18.91
ATOM	938	CG	HIS A	152	56.661	30.333	9.771	1.00	21.17
ATOM	939	CD2	HIS A	152	56.387	29.964	8.496	1.00	21.16
ATOM	940	ND1	HIS A	152	57.499	31.424	9.681	1.00	22.49
ATOM	941	CE1	HIS A	152	57.721	31.704	8.409	1.00	20.95
ATOM	942	NE2	HIS A	152	57.058	30.833	7.669	1.00	22.06
ATOM	943	C	HIS A	152	55.165	27.877	12.329	1.00	18.38
ATOM	944	O	HIS A	152	56.096	27.235	12.818	1.00	17.60
ATOM	945	N	GLY A	153	54.001	28.053	12.953	1.00	17.75
ATOM	946	CA	GLY A	153	53.774	27.460	14.259	1.00	16.61
ATOM	947	C	GLY A	153	54.052	28.398	15.419	1.00	15.59
ATOM	948	O	GLY A	153	54.717	29.419	15.262	1.00	13.71
ATOM	949	N	LEU A	154	53.546	28.035	16.592	1.00	15.84
ATOM	950	CA	LEU A	154	53.713	28.837	17.799	1.00	16.70
ATOM	951	CB	LEU A	154	52.984	28.164	18.970	1.00	13.15
ATOM	952	CG	LEU A	154	51.456	28.175	18.853	1.00	14.44
ATOM	953	CD1	LEU A	154	50.819	27.344	19.964	1.00	9.83
ATOM	954	CD2	LEU A	154	50.969	29.622	18.911	1.00	12.21
ATOM	955	C	LEU A	154	55.167	29.127	18.189	1.00	17.86
ATOM	956	O	LEU A	154	55.521	30.286	18.426	1.00	18.59
ATOM	957	N	SER A	155	56.001	28.088	18.264	1.00	17.56
ATOM	958	CA	SER A	155	57.410	28.262	18.638	1.00	19.51
ATOM	959	CB	SER A	155	58.181	26.944	18.510	1.00	17.58
ATOM	960	OG	SER A	155	57.825	26.045	19.536	1.00	26.25
ATOM	961	C	SER A	155	58.139	29.320	17.816	1.00	19.49
ATOM	962	O	SER A	155	58.681	30.283	18.366	1.00	19.42
ATOM	963	N	VAL A	156	58.171	29.131	16.500	1.00	17.97
ATOM	964	CA	VAL A	156	58.856	30.081	15.640	1.00	19.36
ATOM	965	CB	VAL A	156	58.746	29.679	14.152	1.00	19.76
ATOM	966	CG1	VAL A	156	59.197	30.834	13.270	1.00	18.20
ATOM	967	CG2	VAL A	156	59.616	28.452	13.884	1.00	15.89
ATOM	968	C	VAL A	156	58.346	31.509	15.821	1.00	19.10
ATOM	969	O	VAL A	156	59.141	32.440	15.945	1.00	21.48
ATOM	970	N	VAL A	157	57.029	31.686	15.846	1.00	17.35
ATOM	971	CA	VAL A	157	56.465	33.021	16.013	1.00	17.52
ATOM	972	CB	VAL A	157	54.927	33.012	15.806	1.00	18.44
ATOM	973	CG1	VAL A	157	54.354	34.404	16.046	1.00	15.23
ATOM	974	CG2	VAL A	157	54.600	32.545	14.393	1.00	16.29
ATOM	975	C	VAL A	157	56.792	33.557	17.404	1.00	17.04
ATOM	976	O	VAL A	157	57.067	34.742	17.576	1.00	16.81
ATOM	977	N	GLU A	158	56.770	32.668	18.393	1.00	18.06
ATOM	978	CA	GLU A	158	57.073	33.031	19.772	1.00	17.48
ATOM	979	CB	GLU A	158	57.027	31.784	20.657	1.00	18.28
ATOM	980	CG	GLU A	158	57.403	32.037	22.108	1.00	20.80
ATOM	981	CD	GLU A	158	57.983	30.802	22.777	1.00	22.98
ATOM	982	OE1	GLU A	158	57.303	29.760	22.803	1.00	27.17
ATOM	983	OE2	GLU A	158	59.123	30.871	23.276	1.00	24.43
ATOM	984	C	GLU A	158	58.456	33.679	19.877	1.00	16.66
ATOM	985	O	GLU A	158	58.604	34.773	20.423	1.00	15.53
ATOM	986	N	HIS A	159	59.467	32.999	19.350	1.00	16.18
ATOM	987	CA	HIS A	159	60.831	33.515	19.395	1.00	18.93
ATOM	988	CB	HIS A	159	61.809	32.435	18.925	1.00	20.44
ATOM	989	CG	HIS A	159	61.858	31.248	19.833	1.00	25.76
ATOM	990	CD2	HIS A	159	62.038	31.161	21.173	1.00	26.46
ATOM	991	ND1	HIS A	159	61.666	29.957	19.388	1.00	29.18
ATOM	992	CE1	HIS A	159	61.723	29.127	20.414	1.00	29.23
ATOM	993	NE2	HIS A	159	61.947	29.832	21.508	1.00	30.03
ATOM	994	C	HIS A	159	60.986	34.772	18.555	1.00	17.73
ATOM	995	O	HIS A	159	61.760	35.664	18.892	1.00	18.91
ATOM	996	N	ARG A	160	60.237	34.840	17.465	1.00	17.89
ATOM	997	CA	ARG A	160	60.281	35.990	16.574	1.00	19.60
ATOM	998	CB	ARG A	160	59.516	35.652	15.293	1.00	20.86
ATOM	999	CG	ARG A	160	59.537	36.703	14.206	1.00	21.57
ATOM	1000	CD	ARG A	160	58.928	36.111	12.933	1.00	24.64
ATOM	1001	NE	ARG A	160	59.805	35.113	12.323	1.00	23.48
ATOM	1002	CZ	ARG A	160	59.388	34.084	11.587	1.00	24.74
ATOM	1003	NH1	ARG A	160	58.092	33.895	11.365	1.00	22.08
ATOM	1004	NH2	ARG A	160	60.273	33.250	11.056	1.00	21.93
ATOM	1005	C	ARG A	160	59.693	37.227	17.269	1.00	20.13
ATOM	1006	O	ARG A	160	60.167	38.346	17.069	1.00	20.73
ATOM	1007	N	LEU A	161	58.669	37.030	18.093	1.00	19.56
ATOM	1008	CA	LEU A	161	58.073	38.154	18.812	1.00	19.51
ATOM	1009	CB	LEU A	161	56.632	37.833	19.226	1.00	19.35
ATOM	1010	CG	LEU A	161	55.606	37.704	18.092	1.00	20.03
ATOM	1011	CD1	LEU A	161	54.225	37.460	18.685	1.00	18.09
ATOM	1012	CD2	LEU A	161	55.599	38.974	17.248	1.00	16.90
ATOM	1013	C	LEU A	161	58.911	38.497	20.048	1.00	18.36
ATOM	1014	O	LEU A	161	58.990	39.654	20.454	1.00	17.75
ATOM	1015	N	ARG A	162	59.545	37.489	20.640	1.00	17.94
ATOM	1016	CA	ARG A	162	60.385	37.717	21.814	1.00	17.80
ATOM	1017	CB	ARG A	162	60.853	36.392	22.412	1.00	16.66
ATOM	1018	CG	ARG A	162	59.814	35.688	23.264	1.00	17.05
ATOM	1019	CD	ARG A	162	60.431	34.482	23.946	1.00	16.29
ATOM	1020	NE	ARG A	162	59.503	33.831	24.862	1.00	15.68
ATOM	1021	CZ	ARG A	162	59.806	32.758	25.584	1.00	16.71
ATOM	1022	NH1	ARG A	162	61.018	32.219	25.493	1.00	15.01
ATOM	1023	NH2	ARG A	162	58.900	32.220	26.391	1.00	16.25
ATOM	1024	C	ARG A	162	61.605	38.566	21.482	1.00	17.51
ATOM	1025	O	ARG A	162	62.080	39.329	22.320	1.00	17.44
ATOM	1026	N	ALA A	163	62.106	38.431	20.258	1.00	17.07
ATOM	1027	CA	ALA A	163	63.275	39.188	19.825	1.00	16.71
ATOM	1028	CB	ALA A	163	63.727	38.711	18.450	1.00	15.44
ATOM	1029	C	ALA A	163	62.998	40.688	19.786	1.00	16.78
ATOM	1030	O	ALA A	163	63.927	41.489	19.687	1.00	14.49
ATOM	1031	N	ARG A	164	61.723	41.062	19.867	1.00	17.00
ATOM	1032	CA	ARG A	164	61.334	42.468	19.834	1.00	18.86
ATOM	1033	CB	ARG A	164	60.782	42.836	18.451	1.00	19.13
ATOM	1034	CG	ARG A	164	59.511	42.079	18.068	1.00	19.61
ATOM	1035	CD	ARG A	164	59.029	42.462	16.674	1.00	17.87
ATOM	1036	NE	ARG A	164	58.541	43.837	16.610	1.00	17.41
ATOM	1037	CZ	ARG A	164	57.361	44.237	17.074	1.00	19.05
ATOM	1038	NH1	ARG A	164	56.533	43.364	17.639	1.00	17.96
ATOM	1039	NH2	ARG A	164	57.004	45.511	16.970	1.00	18.08
ATOM	1040	C	ARG A	164	60.278	42.776	20.882	1.00	19.19
ATOM	1041	O	ARG A	164	59.597	43.797	20.795	1.00	19.50
ATOM	1042	N	GLN A	165	60.152	41.900	21.874	1.00	20.49
ATOM	1043	CA	GLN A	165	59.155	42.073	22.924	1.00	20.58
ATOM	1044	CB	GLN A	165	59.274	40.936	23.954	1.00	20.12
ATOM	1045	CG	GLN A	165	58.313	41.046	25.145	1.00	21.82
ATOM	1046	CD	GLN A	165	58.141	39.729	25.904	1.00	22.47
ATOM	1047	OE1	GLN A	165	59.064	38.921	25.994	1.00	22.27
ATOM	1048	NE2	GLN A	165	56.954	39.520	26.464	1.00	21.18
ATOM	1049	C	GLN A	165	59.205	43.433	23.623	1.00	21.76
ATOM	1050	O	GLN A	165	58.161	44.037	23.888	1.00	22.56
ATOM	1051	N	GLN A	166	60.405	43.926	23.914	1.00	21.90
ATOM	1052	CA	GLN A	166	60.533	45.209	24.595	1.00	22.73
ATOM	1053	CB	GLN A	166	61.931	45.366	25.194	1.00	25.53
ATOM	1054	CG	GLN A	166	62.185	44.389	26.321	1.00	27.06
ATOM	1055	CD	GLN A	166	61.005	44.313	27.268	1.00	28.22
ATOM	1056	OE1	GLN A	166	60.585	45.321	27.834	1.00	28.38
ATOM	1057	NE2	GLN A	166	60.456	43.116	27.437	1.00	29.05
ATOM	1058	C	GLN A	166	60.218	46.382	23.693	1.00	22.07
ATOM	1059	O	GLN A	166	59.645	47.378	24.138	1.00	20.88
ATOM	1060	N	LYS A	167	60.597	46.271	22.425	1.00	21.93
ATOM	1061	CA	LYS A	167	60.307	47.334	21.478	1.00	21.45
ATOM	1062	CB	LYS A	167	60.884	47.006	20.101	1.00	21.05
ATOM	1063	CG	LYS A	167	60.402	47.954	19.027	1.00	25.54
ATOM	1064	CD	LYS A	167	60.905	47.574	17.648	1.00	30.01
ATOM	1065	CE	LYS A	167	62.375	47.894	17.486	1.00	33.62
ATOM	1066	NZ	LYS A	167	62.788	47.798	16.057	1.00	36.58
ATOM	1067	C	LYS A	167	58.787	47.467	21.379	1.00	20.51
ATOM	1068	O	LYS A	167	58.248	48.574	21.405	1.00	20.50
ATOM	1069	N	GLN A	168	58.102	46.330	21.274	1.00	19.09
ATOM	1070	CA	GLN A	168	56.646	46.330	21.172	1.00	18.76
ATOM	1071	CB	GLN A	168	56.114	44.906	20.982	1.00	17.10
ATOM	1072	CG	GLN A	168	54.593	44.830	20.823	1.00	17.73
ATOM	1073	CD	GLN A	168	54.072	45.640	19.636	1.00	18.32
ATOM	1074	OE1	GLN A	168	54.439	45.390	18.483	1.00	17.02
ATOM	1075	NE2	GLN A	168	53.210	46.615	19.918	1.00	16.42
ATOM	1076	C	GLN A	168	56.027	46.954	22.413	1.00	17.97
ATOM	1077	O	GLN A	168	55.049	47.689	22.315	1.00	17.66
ATOM	1078	N	ALA A	169	56.608	46.678	23.579	1.00	17.93
ATOM	1079	CA	ALA A	169	56.089	47.243	24.824	1.00	18.74
ATOM	1080	CB	ALA A	169	56.957	46.817	26.005	1.00	18.28
ATOM	1081	C	ALA A	169	56.042	48.766	24.728	1.00	18.92
ATOM	1082	O	ALA A	169	55.083	49.394	25.177	1.00	19.50
ATOM	1083	N	LYS A	170	57.078	49.359	24.143	1.00	19.73
ATOM	1084	CA	LYS A	170	57.122	50.809	23.992	1.00	22.09
ATOM	1085	CB	LYS A	170	58.536	51.278	23.637	1.00	23.45
ATOM	1086	CG	LYS A	170	59.524	51.155	24.791	1.00	28.29
ATOM	1087	CD	LYS A	170	60.839	51.866	24.492	1.00	30.12
ATOM	1088	CE	LYS A	170	61.786	51.792	25.680	1.00	30.79
ATOM	1089	NZ	LYS A	170	62.112	50.377	26.041	1.00	34.64
ATOM	1090	C	LYS A	170	56.138	51.275	22.925	1.00	20.81
ATOM	1091	O	LYS A	170	55.509	52.321	23.072	1.00	20.80
ATOM	1092	N	LEU A	171	56.010	50.499	21.852	1.00	19.17
ATOM	1093	CA	LEU A	171	55.082	50.839	20.778	1.00	18.67
ATOM	1094	CB	LEU A	171	55.199	49.823	19.639	1.00	17.59
ATOM	1095	CG	LEU A	171	56.489	49.947	18.823	1.00	16.99
ATOM	1096	CD1	LEU A	171	56.702	48.707	17.965	1.00	12.77
ATOM	1097	CD2	LEU A	171	56.411	51.210	17.968	1.00	14.39
ATOM	1098	C	LEU A	171	53.651	50.867	21.315	1.00	18.05
ATOM	1099	O	LEU A	171	52.890	51.797	21.040	1.00	15.95
ATOM	1100	N	THR A	172	53.295	49.845	22.088	1.00	18.35
ATOM	1101	CA	THR A	172	51.964	49.756	22.677	1.00	19.52
ATOM	1102	CB	THR A	172	51.801	48.442	23.473	1.00	17.84
ATOM	1103	OG1	THR A	172	51.889	47.330	22.572	1.00	16.09
ATOM	1104	CG2	THR A	172	50.456	48.409	24.186	1.00	14.72
ATOM	1105	C	THR A	172	51.708	50.956	23.595	1.00	21.19
ATOM	1106	O	THR A	172	50.658	51.596	23.517	1.00	19.87
ATOM	1107	N	GLU A	173	52.675	51.263	24.454	1.00	23.39
ATOM	1108	CA	GLU A	173	52.553	52.398	25.362	1.00	26.67
ATOM	1109	CB	GLU A	173	53.799	52.506	26.246	1.00	30.55
ATOM	1110	CG	GLU A	173	53.745	53.637	27.265	1.00	38.76
ATOM	1111	CD	GLU A	173	52.656	53.438	28.317	1.00	43.68
ATOM	1112	OE1	GLU A	173	52.394	54.389	29.089	1.00	44.95
ATOM	1113	OE2	GLU A	173	52.067	52.333	28.378	1.00	45.55
ATOM	1114	C	GLU A	173	52.396	53.673	24.533	1.00	26.37
ATOM	1115	O	GLU A	173	51.811	54.657	24.982	1.00	25.62
ATOM	1116	N	ASP A	174	52.918	53.637	23.313	1.00	27.07
ATOM	1117	CA	ASP A	174	52.845	54.772	22.405	1.00	28.13
ATOM	1118	CB	ASP A	174	54.059	54.770	21.481	1.00	32.94
ATOM	1119	CG	ASP A	174	54.971	55.946	21.724	1.00	38.63
ATOM	1120	OD1	ASP A	174	54.537	57.094	21.468	1.00	40.07
ATOM	1121	OD2	ASP A	174	56.117	55.722	22.176	1.00	40.59
ATOM	1122	C	ASP A	174	51.570	54.793	21.560	1.00	27.18
ATOM	1123	O	ASP A	174	51.445	55.610	20.649	1.00	27.16
ATOM	1124	N	GLY A	175	50.636	53.892	21.851	1.00	24.85
ATOM	1125	CA	GLY A	175	49.393	53.856	21.100	1.00	24.01
ATOM	1126	C	GLY A	175	49.405	52.977	19.860	1.00	23.65
ATOM	1127	O	GLY A	175	48.579	53.159	18.965	1.00	23.96
ATOM	1128	N	LEU A	176	50.330	52.021	19.804	1.00	22.56
ATOM	1129	CA	LEU A	176	50.439	51.117	18.658	1.00	20.60
ATOM	1130	CB	LEU A	176	51.726	51.419	17.887	1.00	19.76
ATOM	1131	CG	LEU A	176	51.773	52.805	17.236	1.00	20.88
ATOM	1132	CD1	LEU A	176	53.156	53.073	16.645	1.00	20.36
ATOM	1133	CD2	LEU A	176	50.698	52.885	16.155	1.00	21.58
ATOM	1134	C	LEU A	176	50.422	49.654	19.107	1.00	19.32
ATOM	1135	O	LEU A	176	51.444	48.968	19.071	1.00	19.23
ATOM	1136	N	PRO A	177	49.241	49.160	19.520	1.00	17.22
ATOM	1137	CD	PRO A	177	48.007	49.957	19.601	1.00	14.81
ATOM	1138	CA	PRO A	177	49.000	47.795	19.998	1.00	16.26
ATOM	1139	CB	PRO A	177	47.534	47.831	20.437	1.00	16.17
ATOM	1140	CG	PRO A	177	47.281	49.277	20.721	1.00	15.79
ATOM	1141	C	PRO A	177	49.264	46.660	19.003	1.00	15.92
ATOM	1142	O	PRO A	177	49.265	46.851	17.784	1.00	15.28
ATOM	1143	N	LEU A	178	49.467	45.470	19.557	1.00	14.24
ATOM	1144	CA	LEU A	178	49.728	44.268	18.779	1.00	15.03
ATOM	1145	CB	LEU A	178	51.130	43.738	19.087	1.00	12.96
ATOM	1146	CG	LEU A	178	51.516	42.404	18.444	1.00	14.74
ATOM	1147	CD1	LEU A	178	51.571	42.573	16.932	1.00	14.67
ATOM	1148	CD2	LEU A	178	52.869	41.938	18.976	1.00	11.17
ATOM	1149	C	LEU A	178	48.702	43.190	19.116	1.00	14.20
ATOM	1150	O	LEU A	178	48.456	42.897	20.283	1.00	15.66
ATOM	1151	N	GLY A	179	48.096	42.609	18.090	1.00	14.51
ATOM	1152	CA	GLY A	179	47.131	41.552	18.309	1.00	11.48
ATOM	1153	C	GLYA	179	47.674	40.287	17.677	1.00	12.92
ATOM	1154	O	GLY A	179	48.433	40.355	16.706	1.00	11.41
ATOM	1155	N	VAL A	180	47.312	39.137	18.235	1.00	12.74
ATOM	1156	CA	VAL A	180	47.754	37.857	17.700	1.00	12.66
ATOM	1157	CB	VAL A	180	48.702	37.135	18.670	1.00	13.16
ATOM	1158	CG1	VAL A	180	49.025	35.746	18.135	1.00	11.92
ATOM	1159	CG2	VAL A	180	49.981	37.946	18.838	1.00	14.00
ATOM	1160	C	VAL A	180	46.535	36.981	17.437	1.00	14.54
ATOM	1161	O	VAL A	180	45.723	36.733	18.334	1.00	15.05
ATOM	1162	N	ASN A	181	46.411	36.523	16.197	1.00	14.43
ATOM	1163	CA	ASN A	181	45.285	35.701	15.774	1.00	16.18
ATOM	1164	CB	ASN A	181	44.913	36.081	14.337	1.00	16.86
ATOM	1165	CG	ASN A	181	43.622	35.450	13.872	1.00	18.28
ATOM	1166	OD1	ASN A	181	43.439	34.233	13.961	1.00	16.72
ATOM	1167	ND2	ASN A	181	42.717	36.278	13.353	1.00	17.72
ATOM	1168	C	ASN A	181	45.657	34.217	15.867	1.00	16.98
ATOM	1169	O	ASN A	181	46.650	33.781	15.281	1.00	17.21
ATOM	1170	N	LEU A	182	44.843	33.452	16.593	1.00	15.71
ATOM	1171	CA	LEU A	182	45.079	32.029	16.804	1.00	16.75
ATOM	1172	CB	LEU A	182	44.890	31.691	18.283	1.00	15.56
ATOM	1173	CG	LEU A	182	45.709	32.502	19.285	1.00	16.48
ATOM	1174	CD1	LEU A	182	45.285	32.136	20.703	1.00	14.81
ATOM	1175	CD2	LEU A	182	47.190	32.233	19.068	1.00	14.85
ATOM	1176	C	LEU A	182	44.187	31.105	15.980	1.00	17.41
ATOM	1177	O	LEU A	182	42.981	31.309	15.876	1.00	18.39
ATOM	1178	N	GLY A	183	44.800	30.078	15.406	1.00	17.73
ATOM	1179	CA	GLY A	183	44.066	29.113	14.613	1.00	18.55
ATOM	1180	C	GLY A	183	44.348	27.733	15.176	1.00	20.03
ATOM	1181	O	GLY A	183	44.939	27.602	16.250	1.00	18.94
ATOM	1182	N	LYS A	184	43.931	26.695	14.465	1.00	20.89
ATOM	1183	CA	LYS A	184	44.172	25.346	14.943	1.00	22.37
ATOM	1184	CB	LYS A	184	42.898	24.755	15.553	1.00	24.26
ATOM	1185	CG	LYS A	184	41.916	24.217	14.540	1.00	28.42
ATOM	1186	CD	LYS A	184	40.864	23.363	15.221	1.00	32.20
ATOM	1187	CE	LYS A	184	40.116	22.506	14.210	1.00	35.25
ATOM	1188	NZ	LYS A	184	41.029	21.545	13.531	1.00	35.90
ATOM	1189	C	LYS A	184	44.672	24.465	13.808	1.00	20.68
ATOM	1190	O	LYS A	184	44.369	24.700	12.644	1.00	21.35
ATOM	1191	N	ASN A	185	45.449	23.452	14.157	1.00	21.49
ATOM	1192	CA	ASN A	185	45.997	22.547	13.161	1.00	22.53
ATOM	1193	CB	ASN A	185	47.052	21.645	13.801	1.00	20.30
ATOM	1194	CG	ASN A	185	48.371	22.360	14.025	1.00	20.21
ATOM	1195	OD1	ASN A	185	48.812	22.536	15.161	1.00	20.64
ATOM	1196	ND2	ASN A	185	49.010	22.773	12.938	1.00	19.38
ATOM	1197	C	ASN A	185	44.940	21.692	12.469	1.00	24.32
ATOM	1198	O	ASN A	185	43.929	21.307	13.063	1.00	22.56
ATOM	1199	N	LYS A	186	45.200	21.392	11.201	1.00	27.23
ATOM	1200	CA	LYS A	186	44.305	20.582	10.390	1.00	30.05
ATOM	1201	CB	LYS A	186	44.886	20.441	8.982	1.00	30.82
ATOM	1202	CG	LYS A	186	44.054	19.581	8.047	1.00	33.61
ATOM	1203	CD	LYS A	186	44.711	19.487	6.685	1.00	35.69
ATOM	1204	CE	LYS A	186	43.865	18.692	5.710	1.00	37.08
ATOM	1205	NZ	LYS A	186	44.525	18.604	4.374	1.00	39.36
ATOM	1206	C	LYS A	186	44.051	19.190	10.981	1.00	31.18
ATOM	1207	O	LYS A	186	42.914	18.726	11.013	1.00	30.53
ATOM	1208	N	THR A	187	45.107	18.530	11.449	1.00	33.43
ATOM	1209	CA	THR A	187	44.973	17.187	12.011	1.00	36.34
ATOM	1210	CB	THR A	187	46.204	16.314	11.685	1.00	36.53
ATOM	1211	OG1	THR A	187	47.348	16.819	12.389	1.00	35.83
ATOM	1212	CG2	THR A	187	46.480	16.323	10.184	1.00	35.68
ATOM	1213	C	THR A	187	44.776	17.175	13.524	1.00	38.23
ATOM	1214	O	THR A	187	44.924	16.134	14.169	1.00	39.65
ATOM	1215	N	SER A	188	44.449	18.330	14.091	1.00	38.70
ATOM	1216	CA	SER A	188	44.225	18.424	15.524	1.00	38.55
ATOM	1217	CB	SER A	188	44.078	19.886	15.940	1.00	38.64
ATOM	1218	OG	SER A	188	43.782	19.988	17.320	1.00	40.20
ATOM	1219	C	SER A	188	42.964	17.654	15.904	1.00	39.15
ATOM	1220	O	SER A	188	42.006	17.601	15.134	1.00	38.68
ATOM	1221	N	VAL A	189	42.971	17.061	17.094	1.00	39.48
ATOM	1222	CA	VAL A	189	41.829	16.296	17.583	1.00	41.01
ATOM	1223	CB	VAL A	189	42.284	14.984	18.260	1.00	41.97
ATOM	1224	CG1	VAL A	189	41.102	14.309	18.927	1.00	42.79
ATOM	1225	CG2	VAL A	189	42.910	14.052	17.230	1.00	41.86
ATOM	1226	C	VAL A	189	41.015	17.101	18.595	1.00	41.66
ATOM	1227	O	VAL A	189	39.789	16.980	18.660	1.00	43.36
ATOM	1228	N	ASP A	190	41.704	17.925	19.379	1.00	40.34
ATOM	1229	CA	ASP A	190	41.055	18.748	20.394	1.00	38.77
ATOM	1230	CB	ASP A	190	41.708	18.502	21.755	1.00	41.42
ATOM	1231	CG	ASP A	190	40.907	19.084	22.900	1.00	43.96
ATOM	1232	OD1	ASP A	190	40.362	20.197	22.746	1.00	44.17
ATOM	1233	OD2	ASP A	190	40.831	18.431	23.961	1.00	48.33
ATOM	1234	C	ASP A	190	41.176	20.228	20.031	1.00	36.65
ATOM	1235	O	ASP A	190	42.153	20.886	20.396	1.00	36.03
ATOM	1236	N	ALA A	191	40.178	20.749	19.322	1.00	33.62
ATOM	1237	CA	ALA A	191	40.181	22.147	18.902	1.00	30.36
ATOM	1238	CB	ALA A	191	38.860	22.493	18.232	1.00	30.25
ATOM	1239	C	ALA A	191	40.433	23.101	20.060	1.00	28.52
ATOM	1240	O	ALA A	191	41.192	24.058	19.930	1.00	26.66
ATOM	1241	N	ALA A	192	39.793	22.835	21.193	1.00	26.87
ATOM	1242	CA	ALA A	192	39.942	23.685	22.367	1.00	25.59
ATOM	1243	CB	ALA A	192	39.013	23.205	23.479	1.00	23.07
ATOM	1244	C	ALA A	192	41.382	23.740	22.871	1.00	25.06
ATOM	1245	O	ALA A	192	41.863	24.804	23.248	1.00	26.91
ATOM	1246	N	GLU A	193	42.067	22.600	22.881	1.00	24.69
ATOM	1247	CA	GLU A	193	43.449	22.553	23.348	1.00	25.36
ATOM	1248	CB	GLU A	193	43.941	21.104	23.430	1.00	28.55
ATOM	1249	CG	GLU A	193	45.386	20.980	23.892	1.00	33.86
ATOM	1250	CD	GLU A	193	45.625	21.605	25.259	1.00	38.09
ATOM	1251	OE1	GLU A	193	46.803	21.800	25.628	1.00	40.81
ATOM	1252	OE2	GLU A	193	44.637	21.895	25.969	1.00	40.22
ATOM	1253	C	GLU A	193	44.373	23.373	22.444	1.00	23.89
ATOM	1254	O	GLU A	193	45.281	24.050	22.929	1.00	23.13
ATOM	1255	N	ASP A	194	44.137	23.309	21.136	1.00	21.11
ATOM	1256	CA	ASP A	194	44.925	24.071	20.171	1.00	21.43
ATOM	1257	CB	ASP A	194	44.373	23.875	18.755	1.00	22.24
ATOM	1258	CG	ASP A	194	45.043	22.736	18.017	1.00	22.08
ATOM	1259	OD1	ASP A	194	45.526	21.802	18.679	1.00	25.23
ATOM	1260	OD2	ASP A	194	45.080	22.768	16.769	1.00	23.80
ATOM	1261	C	ASP A	194	44.910	25.561	20.520	1.00	21.42
ATOM	1262	O	ASP A	194	45.962	26.207	20.552	1.00	22.27
ATOM	1263	N	TYR A	195	43.723	26.110	20.771	1.00	19.34
ATOM	1264	CA	TYR A	195	43.618	27.522	21.119	1.00	19.62
ATOM	1265	CB	TYR A	195	42.159	27.999	21.080	1.00	18.69
ATOM	1266	CG	TYR A	195	41.558	28.005	19.693	1.00	19.61
ATOM	1267	CD1	TYR A	195	40.769	26.953	19.250	1.00	19.06
ATOM	1268	CE1	TYR A	195	40.262	26.930	17.968	1.00	19.80
ATOM	1269	CD2	TYR A	195	41.819	29.043	18.809	1.00	19.96
ATOM	1270	CE2	TYR A	195	41.316	29.030	17.520	1.00	20.62
ATOM	1271	CZ	TYR A	195	40.539	27.970	17.106	1.00	21.15
ATOM	1272	OH	TYR A	195	40.043	27.943	15.822	1.00	22.18
ATOM	1273	C	TYR A	195	44.199	27.762	22.504	1.00	19.30
ATOM	1274	O	TYR A	195	44.812	28.799	22.755	1.00	19.17
ATOM	1275	N	ALA A	196	44.006	26.800	23.401	1.00	19.01
ATOM	1276	CA	ALA A	196	44.530	26.918	24.756	1.00	19.63
ATOM	1277	CB	ALA A	196	44.143	25.697	25.578	1.00	19.27
ATOM	1278	C	ALA A	196	46.051	27.058	24.699	1.00	19.64
ATOM	1279	O	ALA A	196	46.634	27.865	25.426	1.00	19.80
ATOM	1280	N	GLU A	197	46.685	26.274	23.828	1.00	18.51
ATOM	1281	CA	GLU A	197	48.136	26.320	23.667	1.00	21.13
ATOM	1282	CB	GLU A	197	48.615	25.222	22.708	1.00	24.77
ATOM	1283	CG	GLU A	197	48.308	23.810	23.169	1.00	34.07
ATOM	1284	CD	GLU A	197	49.001	22.761	22.321	1.00	38.95
ATOM	1285	OE1	GLU A	197	48.692	21.560	22.478	1.00	40.42
ATOM	1286	OE2	GLU A	197	49.863	23.141	21.501	1.00	43.50
ATOM	1287	C	GLU A	197	48.564	27.679	23.125	1.00	19.10
ATOM	1288	O	GLU A	197	49.540	28.264	23.598	1.00	17.04
ATOM	1289	N	GLY A	198	47.830	28.168	22.128	1.00	16.78
ATOM	1290	CA	GLY A	198	48.136	29.460	21.545	1.00	15.98
ATOM	1291	C	GLY A	198	48.061	30.564	22.582	1.00	14.72
ATOM	1292	O	GLY A	198	48.887	31.476	22.595	1.00	14.32
ATOM	1293	N	VAL A	199	47.061	30.483	23.453	1.00	15.12
ATOM	1294	CA	VAL A	199	46.887	31.471	24.508	1.00	15.39
ATOM	1295	CB	VAL A	199	45.619	31.187	25.345	1.00	15.96
ATOM	1296	CG1	VAL A	199	45.617	32.059	26.599	1.00	12.02
ATOM	1297	CG2	VAL A	199	44.371	31.445	24.505	1.00	15.82
ATOM	1298	C	VAL A	199	48.084	31.458	25.452	1.00	17.58
ATOM	1299	O	VAL A	199	48.561	32.511	25.876	1.00	18.81
ATOM	1300	N	ARG A	200	48.576	30.263	25.769	1.00	16.78
ATOM	1301	CA	ARG A	200	49.709	30.132	26.679	1.00	19.56
ATOM	1302	CB	ARG A	200	49.822	28.693	27.193	1.00	21.47
ATOM	1303	CG	ARG A	200	48.759	28.305	28.205	1.00	24.99
ATOM	1304	CD	ARG A	200	49.163	27.043	28.944	1.00	26.41
ATOM	1305	NE	ARG A	200	49.109	25.863	28.092	1.00	28.52
ATOM	1306	CZ	ARG A	200	48.004	25.167	27.861	1.00	30.32
ATOM	1307	NH1	ARG A	200	46.865	25.536	28.425	1.00	31.74
ATOM	1308	NH2	ARG A	200	48.037	24.102	27.069	1.00	31.33
ATOM	1309	C	ARG A	200	51.052	30.549	26.098	1.00	18.41
ATOM	1310	O	ARG A	200	51.892	31.109	26.805	1.00	18.76
ATOM	1311	N	VAL A	201	51.258	30.281	24.815	1.00	16.94
ATOM	1312	CA	VAL A	201	52.525	30.610	24.181	1.00	14.62
ATOM	1313	CB	VAL A	201	52.843	29.618	23.035	1.00	15.42
ATOM	1314	CG1	VAL A	201	54.164	30.004	22.367	1.00	13.35
ATOM	1315	CG2	VAL A	201	52.919	28.188	23.585	1.00	8.55
ATOM	1316	C	VAL A	201	52.627	32.037	23.643	1.00	16.13
ATOM	1317	O	VAL A	201	53.659	32.691	23.816	1.00	13.21
ATOM	1318	N	LEU A	202	51.565	32.529	23.006	1.00	15.76
ATOM	1319	CA	LEU A	202	51.598	33.875	22.445	1.00	14.49
ATOM	1320	CB	LEU A	202	51.104	33.852	20.999	1.00	15.50
ATOM	1321	CG	LEU A	202	51.984	33.075	20.017	1.00	16.36
ATOM	1322	CD1	LEU A	202	51.499	33.329	18.595	1.00	15.07
ATOM	1323	CD2	LEU A	202	53.439	33.511	20.170	1.00	15.62
ATOM	1324	C	LEU A	202	50.828	34.931	23.233	1.00	15.05
ATOM	1325	O	LEU A	202	51.067	36.125	23.068	1.00	14.28
ATOM	1326	N	GLY A	203	49.906	34.498	24.086	1.00	15.24
ATOM	1327	CA	GLY A	203	49.143	35.444	24.878	1.00	16.41
ATOM	1328	C	GLY A	203	50.007	36.412	25.675	1.00	16.95
ATOM	1329	O	GLY A	203	49.647	37.582	25.841	1.00	13.97
ATOM	1330	N	PRO A	204	51.155	35.953	26.195	1.00	17.99
ATOM	1331	CD	PRO A	204	51.561	34.543	26.328	1.00	17.43
ATOM	1332	CA	PRO A	204	52.045	36.824	26.976	1.00	18.92
ATOM	1333	CB	PRO A	204	53.032	35.835	27.605	1.00	16.96
ATOM	1334	CG	PRO A	204	52.254	34.545	27.658	1.00	17.45
ATOM	1335	C	PRO A	204	52.761	37.885	26.132	1.00	19.12
ATOM	1336	O	PRO A	204	53.361	38.820	26.672	1.00	20.34
ATOM	1337	N	LEU A	205	52.693	37.740	24.812	1.00	17.62
ATOM	1338	CA	LEU A	205	53.355	38.676	23.901	1.00	16.92
ATOM	1339	CB	LEU A	205	54.234	37.896	22.918	1.00	16.82
ATOM	1340	CG	LEU A	205	55.406	37.112	23.519	1.00	18.96
ATOM	1341	CD1	LEU A	205	55.752	35.918	22.646	1.00	16.58
ATOM	1342	CD2	LEU A	205	56.599	38.040	23.679	1.00	17.87
ATOM	1343	C	LEU A	205	52.388	39.558	23.110	1.00	17.18
ATOM	1344	O	LEU A	205	52.810	40.324	22.241	1.00	16.67
ATOM	1345	N	ALA A	206	51.099	39.469	23.417	1.00	16.36
ATOM	1346	CA	ALA A	206	50.108	40.243	22.686	1.00	16.19
ATOM	1347	CB	ALA A	206	49.216	39.295	21.900	1.00	16.04
ATOM	1348	C	ALA A	206	49.245	41.166	23.532	1.00	17.13
ATOM	1349	O	ALA A	206	48.995	40.912	24.708	1.00	18.07
ATOM	1350	N	ASP A	207	48.788	42.251	22.924	1.00	17.38
ATOM	1351	CA	ASP A	207	47.913	43.169	23.627	1.00	18.09
ATOM	1352	CB	ASP A	207	47.941	44.542	22.964	1.00	17.76
ATOM	1353	CG	ASP A	207	49.253	45.267	23.216	1.00	20.83
ATOM	1354	OD1	ASP A	207	49.628	45.409	24.400	1.00	22.34
ATOM	1355	OD2	ASP A	207	49.912	45.691	22.245	1.00	19.95
ATOM	1356	C	ASP A	207	46.519	42.547	23.600	1.00	16.94
ATOM	1357	O	ASP A	207	45.740	42.702	24.534	1.00	16.96
ATOM	1358	N	TYR A	208	46.217	41.825	22.526	1.00	16.01
ATOM	1359	CA	TYR A	208	44.941	41.136	22.420	1.00	16.14
ATOM	1360	CB	TYR A	208	43.843	42.043	21.830	1.00	16.24
ATOM	1361	CG	TYR A	208	43.913	42.321	20.340	1.00	16.53
ATOM	1362	CD1	TYR A	208	44.391	43.540	19.861	1.00	17.20
ATOM	1363	CE1	TYR A	208	44.403	43.824	18.504	1.00	16.56
ATOM	1364	CD2	TYR A	208	43.454	41.388	19.414	1.00	15.47
ATOM	1365	CE2	TYR A	208	43.465	41.659	18.055	1.00	14.96
ATOM	1366	CZ	TYR A	208	43.939	42.878	17.605	1.00	18.58
ATOM	1367	OH	TYR A	208	43.955	43.148	16.254	1.00	18.48
ATOM	1368	C	TYR A	208	45.102	39.879	21.579	1.00	16.18
ATOM	1369	O	TYR A	208	45.899	39.842	20.640	1.00	15.69
ATOM	1370	N	LEU A	209	44.361	38.842	21.951	1.00	16.49
ATOM	1371	CA	LEU A	209	44.385	37.570	21.244	1.00	17.41
ATOM	1372	CB	LEU A	209	44.519	36.407	22.226	1.00	16.83
ATOM	1373	CG	LEU A	209	45.850	36.202	22.939	1.00	17.95
ATOM	1374	CD1	LEU A	209	45.708	35.059	23.936	1.00	18.86
ATOM	1375	CD2	LEU A	209	46.940	35.901	21.916	1.00	16.17
ATOM	1376	C	LEU A	209	43.082	37.413	20.479	1.00	17.21
ATOM	1377	O	LEU A	209	42.036	37.885	20.919	1.00	17.18
ATOM	1378	N	VAL A	210	43.148	36.742	19.336	1.00	18.27
ATOM	1379	CA	VAL A	210	41.962	36.525	18.525	1.00	17.38
ATOM	1380	CB	VAL A	210	42.105	37.155	17.122	1.00	17.53
ATOM	1381	CG1	VAL A	210	40.819	36.931	16.314	1.00	15.25
ATOM	1382	CG2	VAL A	210	42.424	38.633	17.242	1.00	13.97
ATOM	1383	C	VAL A	210	41.688	35.045	18.334	1.00	18.13
ATOM	1384	O	VAL A	210	42.503	34.323	17.767	1.00	18.42
ATOM	1385	N	VAL A	211	40.545	34.589	18.826	1.00	18.92
ATOM	1386	CA	VAL A	211	40.168	33.198	18.638	1.00	18.84
ATOM	1387	CB	VAL A	211	39.141	32.732	19.691	1.00	17.39
ATOM	1388	CG1	VAL A	211	38.712	31.309	19.395	1.00	14.12
ATOM	1389	CG2	VAL A	211	39.741	32.826	21.086	1.00	17.05
ATOM	1390	C	VAL A	211	39.514	33.164	17.256	1.00	19.52
ATOM	1391	O	VAL A	211	38.355	33.554	17.100	1.00	18.05
ATOM	1392	N	ASN A	212	40.265	32.728	16.250	1.00	19.73
ATOM	1393	CA	ASN A	212	39.725	32.665	14.904	1.00	20.91
ATOM	1394	CB	ASN A	212	40.835	32.725	13.858	1.00	19.36
ATOM	1395	CG	ASN A	212	40.287	32.677	12.448	1.00	18.94
ATOM	1396	OD1	ASN A	212	39.074	32.682	12.253	1.00	19.73
ATOM	1397	ND2	ASN A	212	41.169	32.632	11.461	1.00	18.71
ATOM	1398	C	ASN A	212	38.924	31.388	14.714	1.00	22.66
ATOM	1399	O	ASN A	212	39.479	30.291	14.606	1.00	23.56
ATOM	1400	N	VAL A	213	37.610	31.538	14.660	1.00	21.24
ATOM	1401	CA	VAL A	213	36.744	30.387	14.499	1.00	22.82
ATOM	1402	CB	VAL A	213	35.893	30.196	15.768	1.00	23.98
ATOM	1403	CG1	VAL A	213	34.778	31.242	15.822	1.00	23.80
ATOM	1404	CG2	VAL A	213	35.343	28.811	15.800	1.00	27.23
ATOM	1405	C	VAL A	213	35.838	30.579	13.282	1.00	21.82
ATOM	1406	O	VAL A	213	34.813	29.904	13.134	1.00	21.63
ATOM	1407	N	SER A	214	36.243	31.492	12.402	1.00	21.12
ATOM	1408	CA	SER A	214	35.468	31.811	11.211	1.00	19.76
ATOM	1409	CB	SER A	214	35.010	33.270	11.273	1.00	19.69
ATOM	1410	OG	SER A	214	36.100	34.142	11.527	1.00	15.15
ATOM	1411	C	SER A	214	36.181	31.556	9.887	1.00	20.87
ATOM	1412	O	SER A	214	35.712	31.995	8.837	1.00	18.78
ATOM	1413	N	SER A	215	37.311	30.859	9.921	1.00	22.57
ATOM	1414	CA	SER A	215	38.012	30.570	8.678	1.00	23.58
ATOM	1415	CB	SER A	215	39.388	29.976	8.951	1.00	25.79
ATOM	1416	OG	SER A	215	40.016	29.608	7.732	1.00	25.68
ATOM	1417	C	SER A	215	37.187	29.571	7.874	1.00	24.56
ATOM	1418	O	SER A	215	36.750	28.544	8.393	1.00	24.98
ATOM	1419	N	PRO A	216	36.955	29.866	6.591	1.00	26.27
ATOM	1420	CD	PRO A	216	37.219	31.148	5.908	1.00	24.27
ATOM	1421	CA	PRO A	216	36.174	28.969	5.737	1.00	27.15
ATOM	1422	CB	PRO A	216	35.594	29.921	4.703	1.00	26.46
ATOM	1423	CG	PRO A	216	36.739	30.875	4.492	1.00	24.79
ATOM	1424	C	PRO A	216	37.035	27.897	5.084	1.00	28.49
ATOM	1425	O	PRO A	216	36.519	27.019	4.398	1.00	30.31
ATOM	1426	N	ASN A	217	38.345	27.966	5.308	1.00	30.00
ATOM	1427	CA	ASN A	217	39.270	27.026	4.686	1.00	31.48
ATOM	1428	CB	ASN A	217	40.438	27.803	4.080	1.00	31.24
ATOM	1429	CG	ASN A	217	39.969	28.926	3.176	1.00	32.97
ATOM	1430	OD1	ASN A	217	39.213	28.699	2.230	1.00	33.41
ATOM	1431	ND2	ASN A	217	40.410	30.147	3.465	1.00	32.16
ATOM	1432	C	ASN A	217	39.792	25.889	5.554	1.00	32.38
ATOM	1433	O	ASN A	217	40.776	25.234	5.204	1.00	31.80
ATOM	1434	N	THR A	218	39.135	25.658	6.685	1.00	33.60
ATOM	1435	CA	THR A	218	39.507	24.567	7.581	1.00	34.67
ATOM	1436	CB	THR A	218	40.182	25.079	8.875	1.00	35.71
ATOM	1437	OG1	THR A	218	41.502	25.553	8.574	1.00	34.15
ATOM	1438	CG2	THR A	218	40.276	23.961	9.902	1.00	34.11
ATOM	1439	C	THR A	218	38.231	23.809	7.933	1.00	35.34
ATOM	1440	O	THR A	218	37.313	24.365	8.539	1.00	35.59
ATOM	1441	N	ALA A	219	38.182	22.541	7.531	1.00	35.68
ATOM	1442	CA	ALA A	219	37.027	21.677	7.761	1.00	35.27
ATOM	1443	CB	ALA A	219	37.366	20.243	7.356	1.00	33.44
ATOM	1444	C	ALA A	219	36.482	21.693	9.185	1.00	35.21
ATOM	1445	O	ALA A	219	37.205	21.424	10.145	1.00	35.80
ATOM	1446	N	GLY A	220	35.196	22.013	9.304	1.00	35.33
ATOM	1447	CA	GLY A	220	34.533	22.038	10.598	1.00	35.53
ATOM	1448	C	GLY A	220	34.909	23.125	11.589	1.00	35.22
ATOM	1449	O	SLY A	220	34.434	23.102	12.723	1.00	35.56
ATOM	1450	N	LEU A	221	35.743	24.079	11.183	1.00	34.69
ATOM	1451	CA	LEU A	221	36.157	25.148	12.088	1.00	34.37
ATOM	1452	CB	LEU A	221	37.303	25.961	11.478	1.00	34.53
ATOM	1453	CG	LEU A	221	37.918	26.976	12.450	1.00	34.35
ATOM	1454	CD1	LEU A	221	38.857	26.238	13.396	1.00	35.01
ATOM	1455	CD2	LEU A	221	38.671	28.060	11.695	1.00	33.25
ATOM	1456	C	LEU A	221	35.012	26.095	12.443	1.00	34.00
ATOM	1457	O	LEU A	221	34.831	26.462	13.605	1.00	34.07
ATOM	1458	N	ARG A	222	34.240	26.491	11.438	1.00	34.48
ATOM	1459	CA	ARG A	222	33.124	27.404	11.650	1.00	34.48
ATOM	1460	CB	ARG A	222	32.544	27.837	10.304	1.00	34.91
ATOM	1461	CG	ARG A	222	33.445	28.786	9.525	1.00	35.80
ATOM	1462	CD	ARG A	222	32.870	29.056	8.148	1.00	38.02
ATOM	1463	NE	ARG A	222	32.938	27.873	7.293	1.00	38.82
ATOM	1464	CZ	ARG A	222	32.210	27.700	6.195	1.00	39.23
ATOM	1465	NH1	ARG A	222	31.349	28.635	5.812	1.00	37.27
ATOM	1466	NH2	ARG A	222	32.348	26.593	5.476	1.00	38.53
ATOM	1467	C	ARG A	222	32.018	26.836	12.536	1.00	34.30
ATOM	1468	O	ARG A	222	31.224	27.592	13.100	1.00	33.00
ATOM	1469	N	SER A	223	31.963	25.514	12.665	1.00	34.10
ATOM	1470	CA	SER A	223	30.940	24.892	13.498	1.00	33.94
ATOM	1471	CB	SER A	223	30.930	23.371	13.311	1.00	32.71
ATOM	1472	OG	SER A	223	32.106	22.778	13.831	1.00	36.35
ATOM	1473	C	SER A	223	31.212	25.236	14.959	1.00	33.63
ATOM	1474	O	SER A	223	30.335	25.103	15.814	1.00	32.92
ATOM	1475	N	LEU A	224	32.433	25.683	15.240	1.00	33.63
ATOM	1476	CA	LEU A	224	32.806	26.062	16.598	1.00	34.04
ATOM	1477	CB	LEU A	224	34.328	26.196	16.721	1.00	33.19
ATOM	1478	CG	LEU A	224	35.192	24.950	16.506	1.00	34.59
ATOM	1479	CD1	LEU A	224	36.664	25.336	16.506	1.00	31.62
ATOM	1480	CD2	LEU A	224	34.900	23.932	17.599	1.00	31.62
ATOM	1481	C	LEU A	224	32.135	27.384	16.974	1.00	33.88
ATOM	1482	O	LEU A	224	32.244	27.845	18.110	1.00	33.46
ATOM	1483	N	GLN A	225	31.452	27.997	16.011	1.00	34.56
ATOM	1484	CA	GLN A	225	30.751	29.251	16.270	1.00	35.35
ATOM	1485	CB	GLN A	225	30.539	30.046	14.970	1.00	34.80
ATOM	1486	CG	GLN A	225	31.825	30.373	14.212	1.00	35.04
ATOM	1487	CD	GLN A	225	31.583	31.194	12.951	1.00	34.62
ATOM	1488	OE1	GLN A	225	31.541	32.428	12.991	1.00	32.02
ATOM	1489	NE2	GLN A	225	31.410	30.508	11.824	1.00	32.11
ATOM	1490	C	GLN A	225	29.402	28.920	16.910	1.00	34.70
ATOM	1491	O	GLN A	225	28.696	29.809	17.386	1.00	34.24
ATOM	1492	N	GLY A	226	29.055	27.634	16.917	1.00	34.70
ATOM	1493	CA	GLY A	226	27.802	27.198	17.516	1.00	34.95
ATOM	1494	C	GLY A	226	27.786	27.497	19.005	1.00	35.26
ATOM	1495	O	GLY A	226	28.831	27.463	19.654	1.00	36.21
ATOM	1496	N	LYS A	227	26.604	27.772	19.549	1.00	34.42
ATOM	1497	CA	LYS A	227	26.453	28.116	20.964	1.00	34.17
ATOM	1498	CB	LYS A	227	24.968	28.234	21.321	1.00	32.71
ATOM	1499	CG	LYS A	227	24.712	28.922	22.658	1.00	32.69
ATOM	1500	CD	LYS A	227	23.236	29.227	22.852	1.00	32.86
ATOM	1501	CE	LYS A	227	22.974	29.932	24.175	1.00	34.60
ATOM	1502	NZ	LYS A	227	23.622	31.274	24.244	1.00	37.35
ATOM	1503	C	LYS A	227	27.142	27.193	21.968	1.00	34.30
ATOM	1504	O	LYS A	227	27.965	27.648	22.764	1.00	33.44
ATOM	1505	N	ALA A	228	26.807	25.906	21.942	1.00	34.25
ATOM	1506	CA	ALA A	228	27.403	24.950	22.877	1.00	35.39
ATOM	1507	CB	ALA A	228	26.742	23.585	22.722	1.00	33.05
ATOM	1508	C	ALA A	228	28.912	24.822	22.681	1.00	35.36
ATOM	1509	O	ALA A	228	29.685	24.947	23.629	1.00	34.05
ATOM	1510	N	GLU A	229	29.322	24.566	21.443	1.00	36.97
ATOM	1511	CA	GLU A	229	30.733	24.424	21.108	1.00	38.17
ATOM	1512	CB	GLU A	229	30.885	24.141	19.608	1.00	42.08
ATOM	1513	CG	GLU A	229	31.463	22.771	19.271	1.00	48.40
ATOM	1514	CD	GLU A	229	31.399	22.459	17.782	1.00	51.77
ATOM	1515	OE1	GLU A	229	30.279	22.273	17.258	1.00	54.82
ATOM	1516	OE2	GLU A	229	32.467	22.402	17.133	1.00	53.10
ATOM	1517	C	GLU A	229	31.506	25.691	21.470	1.00	35.95
ATOM	1518	O	GLU A	229	32.587	25.627	22.052	1.00	36.51
ATOM	1519	N	LEU A	230	30.935	26.842	21.133	1.00	33.64
ATOM	1520	CA	LEU A	230	31.573	28.123	21.399	1.00	30.71
ATOM	1521	CB	LEU A	230	30.768	29.265	20.763	1.00	28.43
ATOM	1522	CG	LEU A	230	31.388	30.665	20.836	1.00	26.75
ATOM	1523	CD1	LEU A	230	32.723	30.679	20.096	1.00	24.08
ATOM	1524	CD2	LEU A	230	30.438	31.680	20.223	1.00	26.42
ATOM	1525	C	LEU A	230	31.751	28.401	22.884	1.00	29.09
ATOM	1526	O	LEU A	230	32.787	28.918	23.300	1.00	28.84
ATOM	1527	N	ARG A	231	30.745	28.065	23.684	1.00	28.50
ATOM	1528	CA	ARG A	231	30.820	28.312	25.118	1.00	28.34
ATOM	1529	CB	ARG A	231	29.473	28.016	25.787	1.00	29.52
ATOM	1530	CG	ARG A	231	29.427	28.407	27.260	1.00	32.29
ATOM	1531	CD	ARG A	231	28.148	27.937	27.936	1.00	36.19
ATOM	1532	NE	ARG A	231	26.969	28.685	27.506	1.00	38.72
ATOM	1533	CZ	ARG A	231	25.885	28.128	26.974	1.00	39.27
ATOM	1534	NH1	ARG A	231	25.833	26.815	26.799	1.00	40.30
ATOM	1535	NH2	ARG A	231	24.848	28.881	26.632	1.00	38.91
ATOM	1536	C	ARG A	231	31.925	27.492	25.788	1.00	27.28
ATOM	1537	O	ARG A	231	32.681	28.015	26.601	1.00	25.62
ATOM	1538	N	ARG A	232	32.014	26.210	25.448	1.00	27.02
ATOM	1539	CA	ARG A	232	33.035	25.343	26.026	1.00	28.51
ATOM	1540	CB	ARG A	232	32.813	23.887	25.603	1.00	31.69
ATOM	1541	CG	ARG A	232	33.898	22.937	26.103	1.00	37.81
ATOM	1542	CD	ARG A	232	33.653	21.483	25.692	1.00	42.26
ATOM	1543	NE	ARG A	232	32.323	21.016	26.081	1.00	46.87
ATOM	1544	CZ	ARG A	232	31.239	21.131	25.318	1.00	49.45
ATOM	1545	NH1	ARG A	232	31.329	21.691	24.118	1.00	49.90
ATOM	1546	NH2	ARG A	232	30.064	20.697	25.758	1.00	49.90
ATOM	1547	C	ARG A	232	34.421	25.793	25.584	1.00	26.98
ATOM	1548	O	ARG A	232	35.372	25.776	26.363	1.00	26.34
ATOM	1549	N	LEU A	233	34.529	26.196	24.324	1.00	25.27
ATOM	1550	CA	LEU A	233	35.796	26.657	23.782	1.00	24.87
ATOM	1551	CB	LEU A	233	35.655	26.912	22.282	1.00	25.82
ATOM	1552	CG	LEU A	233	36.829	27.628	21.615	1.00	26.85
ATOM	1553	CD1	LEU A	233	38.077	26.783	21.734	1.00	28.70
ATOM	1554	CD2	LEU A	233	36.500	27.896	20.161	1.00	28.50
ATOM	1555	C	LEU A	233	36.285	27.932	24.475	1.00	24.30
ATOM	1556	O	LEU A	233	37.423	27.995	24.943	1.00	22.17
ATOM	1557	N	LEU A	234	35.417	28.939	24.546	1.00	22.83
ATOM	1558	CA	LEU A	234	35.767	30.222	25.153	1.00	22.68
ATOM	1559	CB	LEU A	234	34.721	31.278	24.782	1.00	23.83
ATOM	1560	CG	LEU A	234	34.666	31.550	23.275	1.00	26.75
ATOM	1561	CD1	LEU A	234	33.574	32.559	22.952	1.00	28.02
ATOM	1562	CD2	LEU A	234	36.025	32.053	22.815	1.00	26.81
ATOM	1563	C	LEU A	234	35.956	30.183	26.665	1.00	21.66
ATOM	1564	O	LEU A	234	36.697	30.991	27.221	1.00	20.64
ATOM	1565	N	THR A	235	35.286	29.257	27.336	1.00	21.48
ATOM	1566	CA	THR A	235	35.447	29.143	28.779	1.00	22.71
ATOM	1567	CB	THR A	235	34.468	28.115	29.378	1.00	23.15
ATOM	1568	OG1	THR A	235	33.136	28.640	29.321	1.00	24.32
ATOM	1569	CG2	THR A	235	34.833	27.812	30.824	1.00	20.23
ATOM	1570	C	THR A	235	36.882	28.701	29.075	1.00	21.92
ATOM	1571	O	THR A	235	37.530	29.227	29.980	1.00	22.20
ATOM	1572	N	LYS A	236	37.371	27.743	28.293	1.00	19.41
ATOM	1573	CA	LYS A	236	38.724	27.233	28.456	1.00	21.47
ATOM	1574	CB	LYS A	236	38.906	25.956	27.634	1.00	23.11
ATOM	1575	CG	LYS A	236	40.249	25.277	27.855	1.00	30.29
ATOM	1576	CD	LYS A	236	40.274	23.875	27.258	1.00	32.54
ATOM	1577	CE	LYS A	236	41.569	23.162	27.600	1.00	35.14
ATOM	1578	NZ	LYS A	236	41.531	21.727	27.194	1.00	38.21
ATOM	1579	C	LYS A	236	39.766	28.276	28.043	1.00	20.48
ATOM	1580	O	LYS A	236	40.778	28.455	28.720	1.00	19.24
ATOM	1581	N	VAL A	237	39.512	28.966	26.937	1.00	19.58
ATOM	1582	CA	VAL A	237	40.425	29.997	26.456	1.00	19.48
ATOM	1583	CB	VAL A	237	39.911	30.614	25.138	1.00	19.06
ATOM	1584	CG1	VAL A	237	40.647	31.918	24.836	1.00	15.24
ATOM	1585	CG2	VAL A	237	40.104	29.621	24.003	1.00	17.14
ATOM	1586	C	VAL A	237	40.587	31.104	27.495	1.00	20.14
ATOM	1587	O	VAL A	237	41.708	31.499	27.826	1.00	20.24
ATOM	1588	N	LEU A	238	39.462	31.594	28.010	1.00	20.89
ATOM	1589	CA	LEU A	238	39.462	32.657	29.013	1.00	21.10
ATOM	1590	CB	LEU A	238	38.032	33.116	29.296	1.00	19.72
ATOM	1591	CG	LEU A	238	37.359	33.891	28.159	1.00	21.61
ATOM	1592	CD1	LEU A	238	35.889	34.122	28.486	1.00	21.43
ATOM	1593	CD2	LEU A	238	38.079	35.218	27.956	1.00	21.42
ATOM	1594	C	LEU A	238	40.132	32.228	30.315	1.00	21.64
ATOM	1595	O	LEU A	238	40.772	33.041	30.989	1.00	20.34
ATOM	1596	N	GLN A	239	39.986	30.954	30.669	1.00	21.87
ATOM	1597	CA	GLN A	239	40.601	30.446	31.888	1.00	22.65
ATOM	1598	CB	GLN A	239	40.119	29.023	32.185	1.00	24.73
ATOM	1599	CG	GLN A	239	40.644	28.468	33.500	1.00	29.71
ATOM	1600	CD	GLN A	239	40.120	27.073	33.799	1.00	36.85
ATOM	1601	OE1	GLN A	239	38.906	26.850	33.859	1.00	40.00
ATOM	1602	NE2	GLN A	239	41.033	26.126	33.991	1.00	35.90
ATOM	1603	C	GLN A	239	42.122	30.460	31.739	1.00	20.03
ATOM	1604	O	GLN A	239	42.839	30.880	32.645	1.00	20.49
ATOM	1605	N	GLU A	240	42.611	29.996	30.596	1.00	19.71
ATOM	1606	CA	GLU A	240	44.049	29.985	30.344	1.00	20.04
ATOM	1607	CB	GLU A	240	44.346	29.343	28.989	1.00	21.58
ATOM	1608	CG	GLU A	240	44.001	27.864	28.918	1.00	28.50
ATOM	1609	CD	GLU A	240	44.957	26.990	29.720	1.00	32.28
ATOM	1610	OE1	GLU A	240	44.689	25.775	29.834	1.00	36.62
ATOM	1611	OE2	GLU A	240	45.980	27.504	30.225	1.00	32.81
ATOM	1612	C	GLU A	240	44.566	31.424	30.358	1.00	19.32
ATOM	1613	O	GLU A	240	45.654	31.697	30.860	1.00	20.01
ATOM	1614	N	ARG A	241	43.767	32.337	29.811	1.00	17.04
ATOM	1615	CA	ARG A	241	44.120	33.750	29.754	1.00	17.15
ATOM	1616	CB	ARG A	241	43.081	34.504	28.914	1.00	15.66
ATOM	1617	CG	ARG A	241	43.402	35.966	28.629	1.00	15.53
ATOM	1618	CD	ARG A	241	43.191	36.870	29.840	1.00	13.45
ATOM	1619	NE	ARG A	241	41.804	36.911	30.299	1.00	15.41
ATOM	1620	CZ	ARG A	241	40.832	37.624	29.731	1.00	16.80
ATOM	1621	NH1	ARG A	241	39.605	37.584	30.236	1.00	14.85
ATOM	1622	NH2	ARG A	241	41.077	38.384	28.669	1.00	13.90
ATOM	1623	C	ARG A	241	44.218	34.369	31.149	1.00	18.11
ATOM	1624	O	ARG A	241	45.172	35.090	31.445	1.00	16.96
ATOM	1625	N	ASP A	242	43.234	34.093	32.004	1.00	18.89
ATOM	1626	CA	ASP A	242	43.233	34.643	33.358	1.00	18.99
ATOM	1627	CB	ASP A	242	41.902	34.352	34.071	1.00	18.23
ATOM	1628	CG	ASP A	242	40.708	35.016	33.391	1.00	20.88
ATOM	1629	OD1	ASP A	242	40.884	36.078	32.759	1.00	20.84
ATOM	1630	OD2	ASP A	242	39.583	34.484	33.506	1.00	20.07
ATOM	1631	C	ASP A	242	44.393	34.097	34.196	1.00	18.74
ATOM	1632	O	ASP A	242	44.788	34.709	35.188	1.00	18.25
ATOM	1633	N	GLY A	243	44.939	32.955	33.789	1.00	17.54
ATOM	1634	CA	GLY A	243	46.050	32.365	34.517	1.00	17.70
ATOM	1635	C	GLY A	243	47.396	33.010	34.212	1.00	18.91
ATOM	1636	O	GLY A	243	48.415	32.658	34.813	1.00	18.37
ATOM	1637	N	LEU A	244	47.417	33.954	33.277	1.00	18.18
ATOM	1638	CA	LEU A	244	48.665	34.629	32.930	1.00	19.11
ATOM	1639	CB	LEU A	244	48.623	35.130	31.481	1.00	16.84
ATOM	1640	CG	LEU A	244	48.395	34.083	30.391	1.00	17.33
ATOM	1641	CD1	LEU A	244	48.265	34.771	29.046	1.00	16.03
ATOM	1642	CD2	LEU A	244	49.545	33.085	30.388	1.00	18.05
ATOM	1643	C	LEU A	244	48.908	35.810	33.864	1.00	19.01
ATOM	1644	O	LEU A	244	47.964	36.402	34.387	1.00	18.42
ATOM	1645	N	ARG A	245	50.176	36.147	34.073	1.00	19.39
ATOM	1646	CA	ARG A	245	50.523	37.272	34.930	1.00	20.56
ATOM	1647	CB	ARG A	245	52.046	37.354	35.091	1.00	19.53
ATOM	1648	CG	ARG A	245	52.602	36.290	36.052	1.00	19.09
ATOM	1649	CD	ARG A	245	54.072	35.987	35.813	1.00	18.19
ATOM	1650	NE	ARG A	245	54.973	37.051	36.252	1.00	19.29
ATOM	1651	CZ	ARG A	245	55.412	37.201	37.499	1.00	19.63
ATOM	1652	NH1	ARG A	245	56.233	38.201	37.796	1.00	15.65
ATOM	1653	NH2	ARG A	245	55.036	36.350	38.449	1.00	17.09
ATOM	1654	C	ARG A	245	49.951	38.569	34.353	1.00	22.53
ATOM	1655	O	ARG A	245	49.890	38.748	33.133	1.00	21.12
ATOM	1656	N	ARG A	246	49.525	39.456	35.250	1.00	25.32
ATOM	1657	CA	ARG A	246	48.920	40.747	34.914	1.00	27.15
ATOM	1658	CB	ARG A	246	49.004	41.683	36.124	1.00	30.54
ATOM	1659	CG	ARG A	246	48.337	41.129	37.369	1.00	37.47
ATOM	1660	CD	ARG A	246	46.817	41.284	37.328	1.00	41.51
ATOM	1661	NE	ARG A	246	46.136	40.393	38.270	1.00	41.54
ATOM	1662	CZ	ARG A	246	46.497	40.210	39.536	1.00	40.36
ATOM	1663	NH1	ARG A	246	47.545	40.851	40.037	1.00	39.56
ATOM	1664	NH2	ARG A	246	45.806	39.382	40.305	1.00	41.42
ATOM	1665	C	ARG A	246	49.442	41.490	33.687	1.00	26.72
ATOM	1666	O	ARG A	246	48.677	41.765	32.762	1.00	26.83
ATOM	1667	N	VAL A	247	50.730	41.829	33.672	1.00	24.53
ATOM	1668	CA	VAL A	247	51.277	42.569	32.538	1.00	24.80
ATOM	1669	CB	VAL A	247	52.717	43.100	32.833	1.00	26.08
ATOM	1670	CG1	VAL A	247	52.681	44.081	34.000	1.00	23.05
ATOM	1671	CG2	VAL A	247	53.653	41.955	33.144	1.00	26.28
ATOM	1672	C	VAL A	247	51.285	41.778	31.233	1.00	24.65
ATOM	1673	O	VAL A	247	51.421	42.354	30.155	1.00	26.53
ATOM	1674	N	HIS A	248	51.117	40.463	31.331	1.00	23.77
ATOM	1675	CA	HIS A	248	51.114	39.592	30.156	1.00	22.18
ATOM	1676	CB	HIS A	248	52.113	38.451	30.365	1.00	21.01
ATOM	1677	CG	HIS A	248	53.530	38.911	30.488	1.00	21.43
ATOM	1678	CD2	HIS A	248	54.309	39.116	31.576	1.00	21.00
ATOM	1679	ND1	HIS A	248	54.285	39.292	29.399	1.00	20.19
ATOM	1680	CE1	HIS A	248	55.466	39.715	29.812	1.00	21.23
ATOM	1681	NE2	HIS A	248	55.506	39.619	31.129	1.00	21.42
ATOM	1682	C	HIS A	248	49.730	39.011	29.877	1.00	21.79
ATOM	1683	O	HIS A	248	49.606	37.986	29.205	1.00	20.09
ATOM	1684	N	ARG A	249	48.697	39.677	30.384	1.00	20.02
ATOM	1685	CA	ARG A	249	47.321	39.218	30.215	1.00	21.28
ATOM	1686	CB	ARG A	249	46.593	39.354	31.553	1.00	21.65
ATOM	1687	CG	ARG A	249	45.352	38.510	31.701	1.00	23.99
ATOM	1688	CD	ARG A	249	44.761	38.702	33.092	1.00	25.10
ATOM	1689	NE	ARG A	249	45.644	38.192	34.136	1.00	25.46
ATOM	1690	CZ	ARG A	249	45.657	38.631	35.390	1.00	26.82
ATOM	1691	NH1	ARG A	249	44.838	39.601	35.769	1.00	26.65
ATOM	1692	NH2	ARG A	249	46.487	38.092	36.272	1.00	28.01
ATOM	1693	C	ARG A	249	46.585	40.002	29.115	1.00	21.29
ATOM	1694	O	ARG A	249	46.166	41.144	29.315	1.00	20.84
ATOM	1695	N	PRO A	250	46.405	39.382	27.938	1.00	19.97
ATOM	1696	CD	PRO A	250	46.882	38.037	27.565	1.00	19.93
ATOM	1697	CA	PRO A	250	45.728	40.015	26.805	1.00	19.36
ATOM	1698	CB	PRO A	250	46.268	39.231	25.621	1.00	17.55
ATOM	1699	CG	PRO A	250	46.266	37.837	26.173	1.00	18.15
ATOM	1700	C	PRO A	250	44.202	39.976	26.834	1.00	19.85
ATOM	1701	O	PRO A	250	43.586	39.166	27.541	1.00	18.01
ATOM	1702	N	ALA A	251	43.603	40.868	26.052	1.00	18.13
ATOM	1703	CA	ALA A	251	42.158	40.914	25.916	1.00	17.04
ATOM	1704	CB	ALA A	251	41.730	42.233	25.293	1.00	15.49
ATOM	1705	C	ALA A	251	41.862	39.761	24.958	1.00	16.50
ATOM	1706	O	ALA A	251	42.714	39.395	24.142	1.00	15.91
ATOM	1707	N	VAL A	252	40.675	39.178	25.059	1.00	15.16
ATOM	1708	CA	VAL A	252	40.318	38.081	24.174	1.00	16.05
ATOM	1709	CB	VAL A	252	39.994	36.794	24.971	1.00	17.17
ATOM	1710	CG1	VAL A	252	39.431	35.727	24.033	1.00	13.39
ATOM	1711	CG2	VAL A	252	41.260	36.279	25.668	1.00	14.93
ATOM	1712	C	VAL A	252	39.121	38.436	23.296	1.00	17.27
ATOM	1713	O	VAL A	252	38.048	38.778	23.791	1.00	17.33
ATOM	1714	N	LEU A	253	39.322	38.370	21.984	1.00	17.39
ATOM	1715	CA	LEU A	253	38.261	38.659	21.030	1.00	16.46
ATOM	1716	CB	LEU A	253	38.670	39.792	20.082	1.00	16.40
ATOM	1717	CG	LEU A	253	38.850	41.201	20.660	1.00	17.88
ATOM	1718	CD1	LEU A	253	40.172	41.298	21.409	1.00	18.95
ATOM	1719	CD2	LEU A	253	38.818	42.212	19.530	1.00	17.21
ATOM	1720	C	LEU A	253	37.987	37.397	20.224	1.00	16.20
ATOM	1721	O	LEU A	253	38.817	36.489	20.186	1.00	15.34
ATOM	1722	N	VAL A	254	36.817	37.345	19.595	1.00	15.06
ATOM	1723	CA	VAL A	254	36.424	36.212	18.768	1.00	15.95
ATOM	1724	CB	VAL A	254	35.152	35.510	19.335	1.00	17.77
ATOM	1725	CG1	VAL A	254	34.647	34.452	18.363	1.00	18.39
ATOM	1726	CG2	VAL A	254	35.471	34.858	20.671	1.00	17.11
ATOM	1727	C	VAL A	254	36.136	36.737	17.363	1.00	15.21
ATOM	1728	O	VAL A	254	35.395	37.697	17.197	1.00	16.49
ATOM	1729	N	LYS A	255	36.739	36.120	16.355	1.00	15.79
ATOM	1730	CA	LYS A	255	36.526	36.546	14.978	1.00	15.67
ATOM	1731	CB	LYS A	255	37.831	36.464	14.181	1.00	14.99
ATOM	1732	CG	LYS A	255	37.716	36.986	12.763	1.00	16.27
ATOM	1733	CD	LYS A	255	39.091	37.270	12.164	1.00	17.90
ATOM	1734	CE	LYS A	255	38.977	37.918	10.785	1.00	16.12
ATOM	1735	NZ	LYS A	255	40.306	38.385	10.305	1.00	17.24
ATOM	1736	C	LYS A	255	35.464	35.660	14.343	1.00	17.11
ATOM	1737	O	LYS A	255	35.618	34.437	14.262	1.00	15.75
ATOM	1738	N	ILE A	256	34.389	36.288	13.883	1.00	15.78
ATOM	1739	CA	ILE A	256	33.284	35.555	13.294	1.00	15.09
ATOM	1740	CB	ILE A	256	31.970	35.932	13.992	1.00	14.37
ATOM	1741	CG2	ILE A	256	32.129	35.743	15.489	1.00	14.88
ATOM	1742	CG1	ILE A	256	31.611	37.391	13.687	1.00	13.35
ATOM	1743	CD1	ILE A	256	30.324	37.871	14.348	1.00	10.32
ATOM	1744	C	ILE A	256	33.119	35.753	11.794	1.00	15.04
ATOM	1745	O	ILE A	256	33.681	36.678	11.203	1.00	12.31
ATOM	1746	N	ALA A	257	32.335	34.869	11.189	1.00	14.83
ATOM	1747	CA	ALA A	257	32.074	34.922	9.758	1.00	18.10
ATOM	1748	CB	ALA A	257	31.756	33.517	9.236	1.00	19.52
ATOM	1749	C	ALA A	257	30.922	35.868	9.426	1.00	18.66
ATOM	1750	O	ALA A	257	30.195	36.328	10.310	1.00	18.10
ATOM	1751	N	PRO A	258	30.771	36.194	8.135	1.00	18.73
ATOM	1752	CD	PRO A	258	31.860	36.055	7.148	1.00	17.46
ATOM	1753	CA	PRO A	258	29.722	37.075	7.621	1.00	19.04
ATOM	1754	CB	PRO A	258	30.441	37.839	6.524	1.00	17.64
ATOM	1755	CG	PRO A	258	31.295	36.767	5.926	1.00	16.87
ATOM	1756	C	PRO A	258	28.571	36.234	7.059	1.00	21.92
ATOM	1757	O	PRO A	258	27.612	36.769	6.500	1.00	22.89
ATOM	1758	N	ASP A	259	28.677	34.915	7.214	1.00	21.14
ATOM	1759	CA	ASP A	259	27.668	33.995	6.699	1.00	22.52
ATOM	1760	CB	ASP A	259	28.346	32.914	5.849	1.00	20.83
ATOM	1761	CG	ASP A	259	29.371	33.489	4.889	1.00	22.44
ATOM	1762	OD1	ASP A	259	29.029	34.444	4.159	1.00	19.29
ATOM	1763	OD2	ASP A	259	30.518	32.985	4.861	1.00	22.71
ATOM	1764	C	ASP A	259	26.849	33.333	7.803	1.00	23.56
ATOM	1765	O	ASP A	259	26.277	32.265	7.605	1.00	24.81
ATOM	1766	N	LEU A	260	26.790	33.975	8.963	1.00	23.55
ATOM	1767	CA	LEU A	260	26.048	33.440	10.097	1.00	22.28
ATOM	1768	CB	LEU A	260	26.566	34.064	11.397	1.00	22.44
ATOM	1769	CG	LEU A	260	28.031	33.801	11.760	1.00	24.01
ATOM	1770	CD1	LEU A	260	28.439	34.667	12.947	1.00	25.25
ATOM	1771	CD2	LEU A	260	28.215	32.329	12.079	1.00	22.47
ATOM	1772	C	LEU A	260	24.552	33.705	9.978	1.00	21.83
ATOM	1773	O	LEU A	260	24.140	34.741	9.461	1.00	23.40
ATOM	1774	N	THR A	261	23.742	32.764	10.453	1.00	20.47
ATOM	1775	CA	THR A	261	22.291	32.925	10.433	1.00	19.70
ATOM	1776	CB	THR A	261	21.558	31.590	10.712	1.00	18.67
ATOM	1777	OG1	THR A	261	21.930	31.106	12.011	1.00	18.39
ATOM	1778	CG2	THR A	261	21.908	30.545	9.665	1.00	12.17
ATOM	1779	C	THR A	261	21.951	33.882	11.576	1.00	21.78
ATOM	1780	O	THR A	261	22.805	34.185	12.411	1.00	22.78
ATOM	1781	N	SER A	262	20.714	34.361	11.619	1.00	21.77
ATOM	1782	CA	SER A	262	20.312	35.256	12.696	1.00	22.54
ATOM	1783	CB	SER A	262	18.882	35.748	12.474	1.00	23.02
ATOM	1784	OG	SER A	262	18.810	36.562	11.322	1.00	26.73
ATOM	1785	C	SER A	262	20.403	34.525	14.038	1.00	22.61
ATOM	1786	O	SER A	262	20.634	35.143	15.076	1.00	21.53
ATOM	1787	N	GLN A	263	20.222	33.208	14.007	1.00	21.94
ATOM	1788	CA	GLN A	263	20.291	32.400	15.219	1.00	22.83
ATOM	1789	CB	GLN A	263	19.786	30.981	14.944	1.00	23.57
ATOM	1790	CG	GLN A	263	19.863	30.049	16.148	1.00	30.01
ATOM	1791	CD	GLN A	263	18.723	30.250	17.133	1.00	31.49
ATOM	1792	OE1	GLN A	263	17.588	29.856	16.870	1.00	32.99
ATOM	1793	NE2	GLN A	263	19.022	30.868	18.269	1.00	32.25
ATOM	1794	C	GLN A	263	21.723	32.338	15.756	1.00	21.26
ATOM	1795	O	GLN A	263	21.947	32.488	16.959	1.00	20.81
ATOM	1796	N	ASP A	264	22.688	32.119	14.865	1.00	21.06
ATOM	1797	CA	ASP A	264	24.088	32.042	15.270	1.00	19.84
ATOM	1798	CB	ASP A	264	25.000	31.772	14.069	1.00	22.89
ATOM	1799	CG	ASP A	264	24.752	30.414	13.431	1.00	25.22
ATOM	1800	OD1	ASP A	264	24.372	29.471	14.158	1.00	22.28
ATOM	1801	OD2	ASP A	264	24.954	30.293	12.201	1.00	26.91
ATOM	1802	C	ASP A	264	24.530	33.334	15.937	1.00	19.05
ATOM	1803	O	ASP A	264	25.200	33.315	16.970	1.00	19.15
ATOM	1804	N	LYS A	265	24.154	34.459	15.340	1.00	17.89
ATOM	1805	CA	LYS A	265	24.518	35.759	15.877	1.00	19.66
ATOM	1806	CB	LYS A	265	24.060	36.864	14.925	1.00	19.31
ATOM	1807	CG	LYS A	265	24.763	36.821	13.580	1.00	19.49
ATOM	1808	CD	LYS A	265	24.098	37.754	12.586	1.00	23.63
ATOM	1809	CE	LYS A	265	24.453	37.370	11.162	1.00	24.49
ATOM	1810	NZ	LYS A	265	23.506	37.954	10.171	1.00	27.62
ATOM	1811	C	LYS A	265	23.931	35.968	17.263	1.00	20.65
ATOM	1812	O	LYS A	265	24.612	36.470	18.157	1.00	21.98
ATOM	1813	N	GLU A	266	22.667	35.590	17.442	1.00	21.27
ATOM	1814	CA	GLU A	266	22.024	35.721	18.743	1.00	20.98
ATOM	1815	CB	GLU A	266	20.566	35.239	18.683	1.00	20.85
ATOM	1816	CG	GLU A	266	19.657	36.112	17.833	1.00	25.52
ATOM	1817	CD	GLU A	266	18.228	35.590	17.739	1.00	26.89
ATOM	1818	OE1	GLU A	266	17.438	36.187	16.983	1.00	29.13
ATOM	1819	OE2	GLU A	266	17.889	34.592	18.414	1.00	27.61
ATOM	1820	C	GLU A	266	22.798	34.886	19.766	1.00	19.97
ATOM	1821	O	GLU A	266	23.099	35.358	20.860	1.00	18.00
ATOM	1822	N	ASP A	267	23.126	33.647	19.402	1.00	20.17
ATOM	1823	CA	ASP A	267	23.860	32.769	20.310	1.00	21.48
ATOM	1824	CB	ASP A	267	24.015	31.365	19.714	1.00	21.94
ATOM	1825	CG	ASP A	267	22.695	30.622	19.619	1.00	25.04
ATOM	1826	OD1	ASP A	267	21.762	30.968	20.376	1.00	23.89
ATOM	1827	OD2	ASP A	267	22.592	29.685	18.797	1.00	27.05
ATOM	1828	C	ASP A	267	25.232	33.336	20.648	1.00	21.55
ATOM	1829	O	ASP A	267	25.619	33.386	21.816	1.00	22.82
ATOM	1830	N	ILE A	268	25.967	33.765	19.628	1.00	19.94
ATOM	1831	CA	ILE A	268	27.287	34.329	19.856	1.00	19.42
ATOM	1832	CB	ILE A	268	27.954	34.753	18.531	1.00	19.50
ATOM	1833	CG2	ILE A	268	29.181	35.611	18.815	1.00	16.97
ATOM	1834	CG1	ILE A	268	28.324	33.505	17.726	1.00	20.05
ATOM	1835	CD1	ILE A	268	28.914	33.798	16.367	1.00	21.73
ATOM	1836	C	ILE A	268	27.201	35.532	20.784	1.00	18.16
ATOM	1837	O	ILE A	268	28.025	35.688	21.683	1.00	18.08
ATOM	1838	N	ALA A	269	26.197	36.376	20.573	1.00	17.88
ATOM	1839	CA	ALA A	269	26.023	37.563	21.405	1.00	19.04
ATOM	1840	CB	ALA A	269	24.885	38.414	20.872	1.00	17.94
ATOM	1841	C	ALA A	269	25.739	37.151	22.845	1.00	20.04
ATOM	1842	O	ALA A	269	26.225	37.769	23.791	1.00	19.17
ATOM	1843	N	SER A	270	24.951	36.094	22.999	1.00	20.63
ATOM	1844	CA	SER A	270	24.598	35.590	24.317	1.00	20.97
ATOM	1845	CB	SER A	270	23.517	34.514	24.182	1.00	20.46
ATOM	1846	OG	SER A	270	23.269	33.883	25.423	1.00	23.18
ATOM	1847	C	SER A	270	25.823	35.024	25.042	1.00	20.72
ATOM	1848	O	SER A	270	26.067	35.351	26.200	1.00	22.09
ATOM	1849	N	VAL A	271	26.590	34.177	24.361	1.00	20.12
ATOM	1850	CA	VAL A	271	27.782	33.582	24.958	1.00	20.78
ATOM	1851	CB	VAL A	271	28.432	32.561	24.004	1.00	19.82
ATOM	1852	CG1	VAL A	271	29.748	32.060	24.592	1.00	20.03
ATOM	1853	CG2	VAL A	271	27.487	31.398	23.773	1.00	16.90
ATOM	1854	C	VAL A	271	28.820	34.647	25.315	1.00	23.07
ATOM	1855	O	VAL A	271	29.419	34.614	26.389	1.00	21.64
ATOM	1856	N	VAL A	272	29.023	35.595	24.406	1.00	25.16
ATOM	1857	CA	VAL A	272	29.981	36.670	24.620	1.00	27.00
ATOM	1858	CB	VAL A	272	29.977	37.649	23.421	1.00	27.76
ATOM	1859	CG1	VAL A	272	30.548	38.995	23.834	1.00	27.78
ATOM	1860	CG2	VAL A	272	30.798	37.058	22.275	1.00	25.76
ATOM	1861	C	VAL A	272	29.710	37.439	25.911	1.00	28.67
ATOM	1862	O	VAL A	272	30.631	37.722	26.682	1.00	29.19
ATOM	1863	N	LYS A	273	28.447	37.767	26.154	1.00	29.06
ATOM	1864	CA	LYS A	273	28.086	38.510	27.356	1.00	31.31
ATOM	1865	CB	LYS A	273	26.736	39.211	27.152	1.00	31.93
ATOM	1866	CG	LYS A	273	26.814	40.342	26.115	1.00	34.44
ATOM	1867	CD	LYS A	273	25.516	41.133	26.008	1.00	36.38
ATOM	1868	Ce	LYS A	273	24.367	40.261	25.534	1.00	35.40
ATOM	1869	NZ	LYS A	273	23.122	41.050	25.352	1.00	36.63
ATOM	1870	C	LYS A	273	28.065	37.636	28.607	1.00	30.65
ATOM	1871	O	LYS A	273	28.303	38.115	29.714	1.00	30.52
ATOM	1872	N	GLU A	274	27.793	36.350	28.426	1.00	29.82
ATOM	1873	CA	GLU A	274	27.765	35.416	29.542	1.00	29.43
ATOM	1874	CB	GLU A	274	27.191	34.074	29.083	1.00	30.26
ATOM	1875	CG	GLU A	274	27.098	33.026	30.176	1.00	35.07
ATOM	1876	CD	GLU A	274	27.060	31.611	29.623	1.00	38.26
ATOM	1877	OE1	GLU A	274	26.381	31.388	28.599	1.00	39.06
ATOM	1878	OE2	GLU A	274	27.706	30.717	30.215	1.00	41.36
ATOM	1879	C	GLU A	274	29.179	35.188	30.094	1.00	29.77
ATOM	1880	O	GLU A	274	29.387	35.174	31.309	1.00	29.55
ATOM	1881	N	LEU A	275	30.145	35.021	29.191	1.00	27.28
ATOM	1882	CA	LEU A	275	31.531	34.754	29.574	1.00	24.61
ATOM	1883	CB	LEU A	275	32.184	33.835	28.542	1.00	22.55
ATOM	1884	CG	LEU A	275	31.489	32.496	28.298	1.00	22.58
ATOM	1885	CD1	LEU A	275	32.236	31.717	27.224	1.00	20.96
ATOM	1886	CD2	LEU A	275	31.435	31.711	29.600	1.00	22.06
ATOM	1887	C	LEU A	275	32.412	35.979	29.764	1.00	23.92
ATOM	1888	O	LEU A	275	33.511	35.873	30.300	1.00	24.92
ATOM	1889	N	GLY A	276	31.943	37.138	29.322	1.00	23.96
ATOM	1890	CA	GLY A	276	32.743	38.340	29.466	1.00	22.49
ATOM	1891	C	GLY A	276	33.783	38.516	28.368	1.00	24.06
ATOM	1892	O	GLY A	276	34.834	39.115	28.597	1.00	23.35
ATOM	1893	N	ILE A	277	33.504	37.991	27.176	1.00	24.12
ATOM	1894	CA	ILE A	277	34.426	38.138	26.051	1.00	22.72
ATOM	1895	CB	ILE A	277	33.814	37.595	24.744	1.00	23.36
ATOM	1896	CG2	ILE A	277	34.734	37.891	23.570	1.00	22.55
ATOM	1897	CG1	ILE A	277	33.609	36.086	24.863	1.00	23.90
ATOM	1898	CD1	ILE A	277	34.891	35.331	25.133	1.00	27.10
ATOM	1899	C	ILE A	277	34.724	39.627	25.885	1.00	22.38
ATOM	1900	O	ILE A	277	33.817	40.461	25.921	1.00	20.66
ATOM	1901	N	ASP A	278	35.997	39.954	25.702	1.00	21.22
ATOM	1902	CA	ASP A	278	36.426	41.340	25.578	1.00	19.68
ATOM	1903	CB	ASP A	278	37.940	41.420	25.751	1.00	19.24
ATOM	1904	CG	ASP A	278	38.389	40.902	27.093	1.00	18.89
ATOM	1905	OD1	ASP A	278	37.973	41.489	28.114	1.00	20.89
ATOM	1906	OD2	ASP A	278	39.145	39.909	27.130	1.00	18.95
ATOM	1907	C	ASP A	278	36.027	42.056	24.300	1.00	19.50
ATOM	1908	O	ASP A	278	35.888	43.277	24.294	1.00	20.84
ATOM	1909	N	GLY A	279	35.844	41.312	23.216	1.00	17.90
ATOM	1910	CA	GLY A	279	35.473	41.961	21.977	1.00	17.02
ATOM	1911	C	GLY A	279	35.240	41.031	20.809	1.00	16.34
ATOM	1912	O	GLY A	279	35.461	39.825	20.896	1.00	16.62
ATOM	1913	N	LEU A	280	34.794	41.609	19.702	1.00	16.08
ATOM	1914	CA	LEU A	280	34.511	40.843	18.501	1.00	16.76
ATOM	1915	CB	LEU A	280	32.999	40.798	18.239	1.00	14.21
ATOM	1916	CG	LEU A	280	32.073	40.052	19.205	1.00	16.52
ATOM	1917	CD1	LEU A	280	30.617	40.361	18.865	1.00	14.62
ATOM	1918	CD2	LEU A	280	32.335	38.555	19.123	1.00	14.09
ATOM	1919	C	LEU A	280	35.190	41.450	17.284	1.00	15.76
ATOM	1920	O	LEU A	280	35.264	42.673	17.142	1.00	15.21
ATOM	1921	N	ILE A	281	35.714	40.586	16.425	1.00	13.97
ATOM	1922	CA	ILE A	281	36.316	41.040	15.188	1.00	14.74
ATOM	1923	CB	ILE A	281	37.668	40.375	14.910	1.00	12.59
ATOM	1924	CG2	ILE A	281	38.237	40.914	13.603	1.00	13.24
ATOM	1925	CG1	ILE A	281	38.637	40.691	16.057	1.00	11.42
ATOM	1926	CD1	ILE A	281	40.099	40.695	15.650	1.00	9.11
ATOM	1927	C	ILE A	281	35.255	40.567	14.218	1.00	16.53
ATOM	1928	O	ILE A	281	35.042	39.362	14.036	1.00	15.17
ATOM	1929	N	VAL A	282	34.561	41.513	13.603	1.00	18.83
ATOM	1930	CA	VAL A	282	33.469	41.111	12.753	1.00	20.72
ATOM	1931	CB	VAL A	282	32.257	42.012	13.007	1.00	20.08
ATOM	1932	CG1	VAL A	282	31.069	41.563	12.177	1.00	15.79
ATOM	1933	CG2	VAL A	282	31.914	41.941	14.486	1.00	15.44
ATOM	1934	C	VAL A	282	33.702	40.896	11.274	1.00	23.98
ATOM	1935	O	VAL A	282	34.040	41.793	10.498	1.00	22.59
ATOM	1936	N	THR A	283	33.464	39.629	10.953	1.00	26.57
ATOM	1937	CA	THR A	283	33.562	38.963	9.669	1.00	24.80
ATOM	1938	CB	THR A	283	32.550	39.499	8.604	1.00	22.20
ATOM	1939	OG1	THR A	283	33.258	39.909	7.430	1.00	20.11
ATOM	1940	CG2	THR A	283	31.692	40.619	9.158	1.00	25.27
ATOM	1941	C	THR A	283	34.915	38.764	9.022	1.00	23.47
ATOM	1942	O	THR A	283	35.729	39.672	8.824	1.00	22.34
ATOM	1943	N	ASN A	284	35.117	37.490	8.739	1.00	20.14
ATOM	1944	CA	ASN A	284	36.271	36.955	8.080	1.00	17.94
ATOM	1945	CB	ASN A	284	36.427	35.498	8.507	1.00	16.23
ATOM	1946	CG	ASN A	284	37.822	34.989	8.327	1.00	15.24
ATOM	1947	OD1	ASN A	284	38.370	35.042	7.234	1.00	16.87
ATOM	1948	ND2	ASN A	284	38.411	34.484	9.406	1.00	15.85
ATOM	1949	C	ASN A	284	35.793	37.038	6.633	1.00	17.29
ATOM	1950	O	ASN A	284	34.912	37.843	6.314	1.00	17.42
ATOM	1951	N	THR A	285	36.346	36.208	5.762	1.00	15.65
ATOM	1952	CA	THR A	285	35.920	36.215	4.371	1.00	14.49
ATOM	1953	CB	THR A	285	36.970	35.548	3.469	1.00	13.54
ATOM	1954	OG1	THR A	285	37.344	34.284	4.030	1.00	11.73
ATOM	1955	CG2	THR A	285	38.205	36.435	3.348	1.00	11.58
ATOM	1956	C	THR A	285	34.600	35.454	4.268	1.00	14.94
ATOM	1957	O	THR A	285	34.250	34.681	5.164	1.00	13.05
ATOM	1958	N	THR A	286	33.872	35.679	3.177	1.00	13.81
ATOM	1959	CA	THR A	286	32.585	35.020	2.961	1.00	12.17
ATOM	1960	CB	THR A	286	31.535	36.022	2.419	1.00	10.38
ATOM	1961	OG1	THR A	286	30.296	35.346	2.200	1.00	13.59
ATOM	1962	CG2	THR A	286	31.996	36.620	1.096	1.00	9.39
ATOM	1963	C	THR A	286	32.679	33.864	1.965	1.00	12.82
ATOM	1964	O	THR A	286	33.406	33.953	0.969	1.00	11.73
ATOM	1965	N	VAL A	287	31.945	32.785	2.234	1.00	12.56
ATOM	1966	CA	VAL A	287	31.926	31.639	1.330	1.00	15.17
ATOM	1967	CB	VAL A	287	31.700	30.290	2.067	1.00	15.85
ATOM	1968	CG1	VAL A	287	32.817	30.045	3.059	1.00	16.20
ATOM	1969	CG2	VAL A	287	30.347	30.285	2.764	1.00	16.12
ATOM	1970	C	VAL A	287	30.783	31.846	0.337	1.00	16.66
ATOM	1971	O	VAL A	287	30.541	31.013	−0.536	1.00	16.82
ATOM	1972	N	SER A	288	30.073	32.959	0.483	1.00	15.63
ATOM	1973	CA	SER A	288	28.985	33.266	−0.432	1.00	15.70
ATOM	1974	CB	SER A	288	28.001	34.259	0.197	1.00	14.48
ATOM	1975	OG	SER A	288	28.554	35.568	0.229	1.00	13.23
ATOM	1976	C	SER A	288	29.611	33.903	−1.665	1.00	16.39
ATOM	1977	O	SER A	288	30.764	34.334	−1.635	1.00	15.81
ATOM	1978	N	ARG A	289	28.847	33.960	−2.747	1.00	17.38
ATOM	1979	CA	ARG A	289	29.318	34.563	−3.985	1.00	18.89
ATOM	1980	CB	ARG A	289	29.629	33.480	−5.019	1.00	18.09
ATOM	1981	CG	ARG A	289	30.839	32.628	−4.671	1.00	18.05
ATOM	1982	CD	ARG A	289	32.125	33.435	−4.745	1.00	16.68
ATOM	1983	NE	ARG A	289	33.299	32.594	−4.532	1.00	15.91
ATOM	1984	CZ	ARG A	289	33.787	32.261	−3.340	1.00	16.31
ATOM	1985	NH1	ARG A	289	34.858	31.477	−3.261	1.00	13.06
ATOM	1986	NH2	ARG A	289	33.220	32.721	−2.229	1.00	13.64
ATOM	1987	C	ARG A	289	28.206	35.475	−4.480	1.00	20.53
ATOM	1988	O	ARG A	289	27.368	35.079	−5.296	1.00	21.36
ATOM	1989	N	PRO A	290	28.182	36.715	−3.975	1.00	19.53
ATOM	1990	CD	PRO A	290	29.209	37.305	−3.100	1.00	17.95
ATOM	1991	CA	PRO A	290	27.176	37.710	−4.343	1.00	18.26
ATOM	1992	CB	PRO A	290	27.763	39.008	−3.793	1.00	18.04
ATOM	1993	CG	PRO A	290	28.515	38.546	−2.589	1.00	17.02
ATOM	1994	C	PRO A	290	26.964	37.767	−5.845	1.00	18.99
ATOM	1995	O	PRO A	290	27.921	37.684	−6.617	1.00	19.64
ATOM	1996	N	ALA A	291	25.707	37.889	−6.262	1.00	18.82
ATOM	1997	CA	ALA A	291	25.405	37.987	−7.685	1.00	16.85
ATOM	1998	CB	ALA A	291	23.901	38.084	−7.899	1.00	14.77
ATOM	1999	C	ALA A	291	26.090	39.255	−8.189	1.00	14.94
ATOM	2000	O	ALA A	291	26.138	40.258	−7.482	1.00	15.17
ATOM	2001	N	GLY A	292	26.636	39.206	−9.398	1.00	13.56
ATOM	2002	CA	GLY A	292	27.295	40.377	−9.939	1.00	14.88
ATOM	2003	C	GLY A	292	28.797	40.238	−10.102	1.00	15.80
ATOM	2004	O	GLY A	292	29.403	41.002	−10.852	1.00	17.47
ATOM	2005	N	LEU A	293	29.406	39.286	−9.398	1.00	15.22
ATOM	2006	CA	LEU A	293	30.846	39.074	−9.520	1.00	15.55
ATOM	2007	CB	LEU A	293	31.282	37.831	−8.739	1.00	15.69
ATOM	2008	CG	LEU A	293	31.174	37.866	−7.210	1.00	14.60
ATOM	2009	CD1	LEU A	293	31.673	36.545	−6.650	1.00	14.40
ATOM	2010	CD2	LEU A	293	31.995	39.020	−6.647	1.00	12.10
ATOM	2011	C	LEU A	293	31.185	38.891	−10.991	1.00	15.60
ATOM	2012	O	LEU A	293	30.510	38.147	−11.702	1.00	16.58
ATOM	2013	N	GLN A	294	32.230	39.576	−11.444	1.00	16.80
ATOM	2014	CA	GLN A	294	32.653	39.503	−12.835	1.00	17.11
ATOM	2015	CB	GLN A	294	32.859	40.913	−13.390	1.00	18.48
ATOM	2016	CG	GLN A	294	31.589	41.728	−13.450	1.00	19.20
ATOM	2017	CD	GLN A	294	30.512	41.030	−14.249	1.00	19.74
ATOM	2018	OE1	GLN A	294	30.709	40.716	−15.420	1.00	20.35
ATOM	2019	NE2	GLN A	294	29.366	40.780	−13.620	1.00	17.29
ATOM	2020	C	GLN A	294	33.929	38.701	−13.029	1.00	18.33
ATOM	2021	O	GLN A	294	34.145	38.122	−14.097	1.00	19.34
ATOM	2022	N	GLY A	295	34.772	38.678	−11.999	1.00	16.78
ATOM	2023	CA	GLY A	295	36.029	37.960	−12.076	1.00	14.58
ATOM	2024	C	GLY A	295	35.915	36.580	−12.693	1.00	17.14
ATOM	2025	O	GLY A	295	34.976	35.828	−12.413	1.00	15.75
ATOM	2026	N	ALA A	296	36.878	36.244	−13.541	1.00	16.27
ATOM	2027	CA	ALA A	296	36.890	34.942	−14.195	1.00	16.90
ATOM	2028	CB	ALA A	296	38.039	34.880	−15.206	1.00	14.08
ATOM	2029	C	ALA A	296	37.030	33.812	−13.175	1.00	16.05
ATOM	2030	O	ALA A	296	36.515	32.712	−13.381	1.00	16.89
ATOM	2031	N	LEU A	297	37.712	34.101	−12.068	1.00	15.74
ATOM	2032	CA	LEU A	297	37.967	33.112	−11.019	1.00	15.01
ATOM	2033	CB	LEU A	297	39.379	33.327	−10.467	1.00	12.31
ATOM	2034	CG	LEU A	297	40.468	33.402	−11.544	1.00	14.81
ATOM	2035	CD1	LEU A	297	41.783	33.870	−10.927	1.00	14.19
ATOM	2036	CD2	LEU A	297	40.627	32.039	−12.214	1.00	12.20
ATOM	2037	C	LEU A	297	36.965	33.148	−9.867	1.00	14.73
ATOM	2038	O	LEU A	297	37.250	32.650	−8.774	1.00	14.27
ATOM	2039	N	ARG A	298	35.793	33.724	−10.123	1.00	15.51
ATOM	2040	CA	ARG A	298	34.743	33.865	−9.112	1.00	15.51
ATOM	2041	CB	ARG A	298	33.558	34.641	−9.699	1.00	14.80
ATOM	2042	CG	ARG A	298	32.734	33.858	−10.711	1.00	14.58
ATOM	2043	CD	ARG A	298	31.673	34.741	−11.370	1.00	15.06
ATOM	2044	NE	ARG A	298	30.782	33.966	−12.229	1.00	14.79
ATOM	2045	CZ	ARG A	298	29.917	34.491	−13.093	1.00	15.35
ATOM	2046	NH1	ARG A	298	29.151	33.695	−13.828	1.00	8.68
ATOM	2047	NH2	ARG A	298	29.822	35.812	−13.233	1.00	14.16
ATOM	2048	C	ARG A	298	34.233	32.553	−8.519	1.00	16.08
ATOM	2049	O	ARG A	298	33.719	32.537	−7.398	1.00	16.02
ATOM	2050	N	SER A	299	34.371	31.458	−9.261	1.00	15.60
ATOM	2051	CA	SER A	299	33.899	30.168	−8.780	1.00	16.40
ATOM	2052	CB	SER A	299	33.206	29.409	−9.910	1.00	15.38
ATOM	2053	OG	SER A	299	31.920	29.958	−10.140	1.00	14.75
ATOM	2054	C	SER A	299	34.958	29.285	−8.124	1.00	17.70
ATOM	2055	O	SER A	299	34.742	28.088	−7.934	1.00	19.57
ATOM	2056	N	GLU A	300	36.099	29.873	−7.782	1.00	15.48
ATOM	2057	CA	GLU A	300	37.153	29.135	−7.096	1.00	16.69
ATOM	2058	CB	GLU A	300	38.473	29.921	−7.109	1.00	15.70
ATOM	2059	CG	GLU A	300	39.177	29.968	−8.460	1.00	19.09
ATOM	2060	CD	GLU A	300	39.894	28.668	−8.796	1.00	19.66
ATOM	2061	OE1	GLU A	300	40.293	28.485	−9.965	1.00	21.52
ATOM	2062	OE2	GLU A	300	40.069	27.831	−7.887	1.00	20.79
ATOM	2063	C	GLU A	300	36.698	28.957	−5.644	1.00	17.50
ATOM	2064	O	GLU A	300	36.012	29.818	−5.085	1.00	18.25
ATOM	2065	N	THR A	301	37.075	27.837	−5.043	1.00	16.77
ATOM	2066	CA	THR A	301	36.733	27.560	−3.657	1.00	15.87
ATOM	2067	CB	THR A	301	37.035	26.089	−3.302	1.00	16.02
ATOM	2068	OG1	THR A	301	36.030	25.245	−3.873	1.00	19.42
ATOM	2069	CG2	THR A	301	37.077	25.894	−1.798	1.00	14.14
ATOM	2070	C	THR A	301	37.564	28.465	−2.747	1.00	14.56
ATOM	2071	O	THR A	301	38.729	28.745	−3.037	1.00	13.06
ATOM	2072	N	GLY A	302	36.968	28.923	−1.651	1.00	14.25
ATOM	2073	CA	GLY A	302	37.697	29.778	−0.732	1.00	13.34
ATOM	2074	C	GLY A	302	36.874	30.924	−0.184	1.00	14.22
ATOM	2075	O	GLY A	302	35.682	31.042	−0.471	1.00	13.86
ATOM	2076	N	GLY A	303	37.514	31.769	0.619	1.00	14.41
ATOM	2077	CA	GLY A	303	36.829	32.906	1.199	1.00	12.84
ATOM	2078	C	GLY A	303	37.005	34.138	0.337	1.00	12.25
ATOM	2079	O	GLY A	303	38.109	34.439	−0.115	1.00	12.09
ATOM	2080	N	LEU A	304	35.906	34.850	0.109	1.00	12.88
ATOM	2081	CA	LEU A	304	35.912	36.057	−0.709	1.00	12.21
ATOM	2082	CB	LEU A	304	34.588	36.171	−1.470	1.00	13.65
ATOM	2083	CG	LEU A	304	34.314	37.450	−2.269	1.00	15.74
ATOM	2084	CD1	LEU A	304	35.287	37.566	−3.428	1.00	16.08
ATOM	2085	CD2	LEU A	304	32.881	37.412	−2.792	1.00	20.89
ATOM	2086	C	LEU A	304	36.120	37.301	0.147	1.00	12.48
ATOM	2087	O	LEU A	304	35.517	37.447	1.211	1.00	14.13
ATOM	2088	N	SER A	305	36.970	38.201	−0.326	1.00	12.36
ATOM	2089	CA	SER A	305	37.253	39.432	0.396	1.00	13.71
ATOM	2090	CB	SER A	305	38.636	39.348	1.042	1.00	13.43
ATOM	2091	OG	SER A	305	39.640	39.207	0.051	1.00	13.79
ATOM	2092	C	SER A	305	37.205	40.615	−0.566	1.00	13.39
ATOM	2093	O	SER A	305	37.120	40.428	−1.778	1.00	14.42
ATOM	2094	N	GLY A	306	37.262	41.830	−0.029	1.00	13.29
ATOM	2095	CA	GLY A	306	37.230	43.002	−0.887	1.00	12.97
ATOM	2096	C	GLY A	306	35.877	43.690	−0.938	1.00	14.84
ATOM	2097	O	GLY A	306	35.009	43.444	−0.096	1.00	14.46
ATOM	2098	N	LYS A	307	35.686	44.539	−1.945	1.00	16.17
ATOM	2099	CA	LYS A	307	34.444	45.290	−2.088	1.00	16.52
ATOM	2100	CB	LYS A	307	34.460	46.120	−3.385	1.00	18.40
ATOM	2101	CG	LYS A	307	33.422	47.261	−3.379	1.00	25.17
ATOM	2102	CD	LYS A	307	33.336	48.025	−4.705	1.00	27.88
ATOM	2103	CE	LYS A	307	34.621	48.787	−5.010	1.00	29.73
ATOM	2104	NZ	LYS A	307	34.986	49.758	−3.934	1.00	29.23
ATOM	2105	C	LYS A	307	33.157	44.466	−2.012	1.00	15.26
ATOM	2106	O	LYS A	307	32.194	44.881	−1.367	1.00	16.38
ATOM	2107	N	PRO A	308	33.114	43.292	−2.663	1.00	14.54
ATOM	2108	CD	PRO A	308	34.114	42.680	−3.556	1.00	14.56
ATOM	2109	CA	PRO A	308	31.894	42.475	−2.613	1.00	14.08
ATOM	2110	CB	PRO A	308	32.255	41.259	−3.465	1.00	14.39
ATOM	2111	CG	PRO A	308	33.248	41.818	−4.448	1.00	15.27
ATOM	2112	C	PRO A	308	31.478	42.074	−1.196	1.00	15.08
ATOM	2113	O	PRO A	308	30.313	41.764	−0.945	1.00	16.18
ATOM	2114	N	LEU A	309	32.436	42.079	−0.276	1.00	15.24
ATOM	2115	CA	LEU A	309	32.182	41.709	1.114	1.00	15.60
ATOM	2116	CB	LEU A	309	33.405	40.979	1.679	1.00	14.32
ATOM	2117	CG	LEU A	309	33.524	40.802	3.201	1.00	13.34
ATOM	2118	CD1	LEU A	309	32.452	39.850	3.714	1.00	12.74
ATOM	2119	CD2	LEU A	309	34.903	40.251	3.532	1.00	12.50
ATOM	2120	C	LEU A	309	31.854	42.890	2.032	1.00	16.28
ATOM	2121	O	LEU A	309	31.229	42.710	3.076	1.00	17.72
ATOM	2122	N	ARG A	310	32.264	44.090	1.633	1.00	14.78
ATOM	2123	CA	ARG A	310	32.084	45.286	2.453	1.00	15.52
ATOM	2124	CB	ARG A	310	32.340	46.553	1.623	1.00	12.86
ATOM	2125	CG	ARG A	310	32.388	47.832	2.468	1.00	14.96
ATOM	2126	CD	ARG A	310	32.520	49.072	1.597	1.00	12.65
ATOM	2127	NE	ARG A	310	31.446	49.104	0.611	1.00	14.57
ATOM	2128	CZ	ARG A	310	31.450	49.852	−0.485	1.00	13.39
ATOM	2129	NH1	ARG A	310	30.422	49.793	−1.320	1.00	11.24
ATOM	2130	NH2	ARG A	310	32.479	50.652	−0.747	1.00	12.51
ATOM	2131	C	ARG A	310	30.772	45.455	3.215	1.00	16.19
ATOM	2132	O	ARG A	310	30.757	45.412	4.445	1.00	16.77
ATOM	2133	N	ASP A	311	29.675	45.659	2.496	1.00	17.50
ATOM	2134	CA	ASP A	311	28.391	45.878	3.147	1.00	17.75
ATOM	2135	CB	ASP A	311	27.381	46.369	2.109	1.00	19.42
ATOM	2136	CG	ASP A	311	27.661	47.809	1.676	1.00	21.08
ATOM	2137	OD1	ASP A	311	28.771	48.309	1.974	1.00	20.69
ATOM	2138	OD2	ASP A	311	26.787	48.441	1.046	1.00	20.67
ATOM	2139	C	ASP A	311	27.864	44.687	3.942	1.00	18.47
ATOM	2140	O	ASP A	311	27.205	44.862	4.969	1.00	17.98
ATOM	2141	N	LEU A	312	28.162	43.478	3.483	1.00	17.76
ATOM	2142	CA	LEU A	312	27.741	42.289	4.207	1.00	17.86
ATOM	2143	CB	LEU A	312	28.179	41.027	3.459	1.00	18.99
ATOM	2144	CG	LEU A	312	27.783	39.686	4.084	1.00	23.39
ATOM	2145	CD1	LEU A	312	26.265	39.602	4.207	1.00	22.84
ATOM	2146	CD2	LEU A	312	28.308	38.538	3.217	1.00	23.42
ATOM	2147	C	LEU A	312	28.410	42.346	5.585	1.00	17.48
ATOM	2148	O	LEU A	312	27.812	41.959	6.592	1.00	16.53
ATOM	2149	N	SER A	313	29.649	42.840	5.621	1.00	16.16
ATOM	2150	CA	SER A	313	30.397	42.971	6.873	1.00	17.10
ATOM	2151	CB	SER A	313	31.873	43.309	6.610	1.00	17.49
ATOM	2152	OG	SER A	313	32.612	42.163	6.244	1.00	23.70
ATOM	2153	C	SER A	313	29.808	44.067	7.749	1.00	15.96
ATOM	2154	O	SER A	313	29.607	43.875	8.949	1.00	16.85
ATOM	2155	N	THR A	314	29.549	45.221	7.143	1.00	13.84
ATOM	2156	CA	THR A	314	28.993	46.353	7.869	1.00	14.33
ATOM	2157	CB	THR A	314	28.745	47.551	6.934	1.00	13.64
ATOM	2158	OG1	THR A	314	29.981	47.935	6.321	1.00	13.07
ATOM	2159	CG2	THR A	314	28.190	48.731	7.715	1.00	12.00
ATOM	2160	C	THR A	314	27.686	45.969	8.541	1.00	14.80
ATOM	2161	O	THR A	314	27.470	46.292	9.707	1.00	16.48
ATOM	2162	N	GLN A	315	26.820	45.269	7.811	1.00	15.30
ATOM	2163	CA	GLN A	315	25.544	44.848	8.370	1.00	14.88
ATOM	2164	CB	GLN A	315	24.658	44.219	7.288	1.00	13.95
ATOM	2165	CG	GLN A	315	24.136	45.209	6.245	1.00	15.23
ATOM	2166	CD	GLN A	315	23.176	46.250	6.828	1.00	15.21
ATOM	2167	OE1	GLN A	315	23.529	46.999	7.735	0.50	14.28
ATOM	2168	NE2	GLN A	315	21.963	46.297	6.297	0.50	12.79
ATOM	2169	C	GLN A	315	25.743	43.869	9.523	1.00	14.34
ATOM	2170	O	GLN A	315	24.981	43.887	10.487	1.00	15.66
ATOM	2171	N	THR A	316	26.765	43.019	9.439	1.00	14.94
ATOM	2172	CA	THR A	316	27.021	42.062	10.521	1.00	13.97
ATOM	2173	CB	THR A	316	28.103	41.018	10.130	1.00	13.18
ATOM	2174	OG1	THR A	316	27.681	40.314	8.958	1.00	14.58
ATOM	2175	CG2	THR A	316	28.306	40.000	11.255	1.00	11.68
ATOM	2176	C	THR A	316	27.479	42.839	11.752	1.00	13.29
ATOM	2177	O	THR A	316	27.133	42.498	12.881	1.00	13.77
ATOM	2178	N	ILE A	317	28.247	43.897	11.522	1.00	13.34
ATOM	2179	CA	ILE A	317	28.728	44.738	12.609	1.00	13.60
ATOM	2180	CB	ILE A	317	29.711	45.803	12.095	1.00	12.88
ATOM	2181	CG2	ILE A	317	29.990	46.820	13.199	1.00	12.51
ATOM	2182	CG1	ILE A	317	30.998	45.132	11.609	1.00	8.92
ATOM	2183	CD1	ILE A	317	31.890	46.038	10.782	1.00	8.20
ATOM	2184	C	ILE A	317	27.548	45.450	13.256	1.00	15.33
ATOM	2185	O	ILE A	317	27.442	45.508	14.482	1.00	14.07
ATOM	2186	N	ARG A	318	26.664	45.985	12.415	1.00	15.26
ATOM	2187	CA	ARG A	318	25.482	46.704	12.876	1.00	16.00
ATOM	2188	CB	ARG A	318	24.653	47.163	11.664	1.00	16.04
ATOM	2189	CG	ARG A	318	23.632	48.262	11.957	1.00	16.53
ATOM	2190	CD	ARG A	318	22.865	48.683	10.697	1.00	15.60
ATOM	2191	NE	ARG A	318	23.731	49.237	9.655	1.00	13.88
ATOM	2192	CZ	ARG A	318	24.404	50.379	9.759	1.00	13.49
ATOM	2193	NH1	ARG A	318	24.316	51.104	10.862	1.00	12.45
ATOM	2194	NH2	ARG A	318	25.178	50.792	8.762	1.00	11.39
ATOM	2195	C	ARG A	318	24.647	45.790	13.781	1.00	17.91
ATOM	2196	O	ARG A	318	24.223	46.179	14.874	1.00	17.43
ATOM	2197	N	GLU A	319	24.438	44.562	13.326	1.00	17.86
ATOM	2198	CA	GLU A	319	23.659	43.589	14.072	1.00	17.86
ATOM	2199	CB	GLU A	319	23.380	42.377	13.176	1.00	20.79
ATOM	2200	CG	GLU A	319	22.533	41.286	13.802	1.00	27.72
ATOM	2201	CD	GLU A	319	21.855	40.408	12.757	1.00	32.40
ATOM	2202	OE1	GLU A	319	22.456	40.189	11.684	1.00	34.24
ATOM	2203	OE2	GLU A	319	20.725	39.929	13.009	1.00	36.06
ATOM	2204	C	GLU A	319	24.317	43.156	15.388	1.00	17.83
ATOM	2205	O	GLU A	319	23.662	43.149	16.431	1.00	16.48
ATOM	2206	N	MET A	320	25.603	42.806	15.359	1.00	17.34
ATOM	2207	CA	MET A	320	26.273	42.379	16.590	1.00	16.86
ATOM	2208	CB	MET A	320	27.683	41.857	16.291	1.00	16.42
ATOM	2209	CG	MET A	320	27.732	40.636	15.371	1.00	13.96
ATOM	2210	SD	MET A	320	26.645	39.265	15.876	1.00	18.68
ATOM	2211	CE	MET A	320	27.333	38.814	17.496	1.00	14.45
ATOM	2212	C	MET A	320	26.340	43.509	17.627	1.00	17.09
ATOM	2213	O	MET A	320	26.256	43.267	18.833	1.00	16.35
ATOM	2214	N	TYR A	321	26.480	44.741	17.151	1.00	17.09
ATOM	2215	CA	TYR A	321	26.542	45.901	18.036	1.00	17.65
ATOM	2216	CB	TYR A	321	26.738	47.172	17.211	1.00	17.64
ATOM	2217	CG	TYR A	321	26.925	48.429	18.032	1.00	18.64
ATOM	2218	CD1	TYR A	321	28.145	48.716	18.637	1.00	17.99
ATOM	2219	CE1	TYR A	321	28.323	49.875	19.369	1.00	17.38
ATOM	2220	CD2	TYR A	321	25.886	49.339	18.187	1.00	16.94
ATOM	2221	CE2	TYR A	321	26.052	50.497	18.916	1.00	15.57
ATOM	2222	CZ	TYR A	321	27.272	50.761	19.504	1.00	17.79
ATOM	2223	OH	TYR A	321	27.439	51.917	20.228	1.00	18.99
ATOM	2224	C	TYR A	321	25.245	46.012	18.844	1.00	18.22
ATOM	2225	O	TYR A	321	25.272	46.221	20.058	1.00	16.92
ATOM	2226	N	ALA A	322	24.115	45.871	18.154	1.00	18.07
ATOM	2227	CA	ALA A	322	22.798	45.951	18.779	1.00	18.52
ATOM	2228	CB	ALA A	322	21.708	46.022	17.698	1.00	15.28
ATOM	2229	C	ALA A	322	22.539	44.764	19.714	1.00	18.01
ATOM	2230	O	ALA A	322	21.979	44.929	20.793	1.00	19.87
ATOM	2231	N	LEU A	323	22.945	43.570	19.301	1.00	17.20
ATOM	2232	CA	LEU A	323	22.752	42.382	20.128	1.00	18.74
ATOM	2233	CB	LEU A	323	23.129	41.124	19.343	1.00	17.37
ATOM	2234	CG	LEU A	323	22.147	40.738	18.232	1.00	18.08
ATOM	2235	CD1	LEU A	323	22.713	39.592	17.407	1.00	15.53
ATOM	2236	CD2	LEU A	323	20.807	40.352	18.854	1.00	16.70
ATOM	2237	C	LEU A	323	23.565	42.446	21.422	1.00	19.90
ATOM	2238	O	LEU A	323	23.201	41.822	22.419	1.00	21.10
ATOM	2239	N	THR A	324	24.664	43.199	21.404	1.00	19.51
ATOM	2240	CA	THR A	324	25.509	43.334	22.585	1.00	19.82
ATOM	2241	CB	THR A	324	27.016	43.159	22.226	1.00	19.33
ATOM	2242	OG1	THR A	324	27.408	44.134	21.250	1.00	17.08
ATOM	2243	CG2	THR A	324	27.269	41.768	21.662	1.00	18.20
ATOM	2244	C	THR A	324	25.304	44.679	23.291	1.00	21.29
ATOM	2245	O	THR A	324	26.094	45.066	24.151	1.00	21.80
ATOM	2246	N	GLN A	325	24.242	45.388	22.920	1.00	22.83
ATOM	2247	CA	GLN A	325	23.925	46.679	23.525	1.00	24.26
ATOM	2248	CB	GLN A	325	23.529	46.502	24.995	1.00	27.36
ATOM	2249	CG	GLN A	325	22.185	45.830	25.223	1.00	30.52
ATOM	2250	CD	GLN A	325	22.121	44.440	24.633	1.00	35.25
ATOM	2251	OE1	GLN A	325	22.909	43.563	24.991	1.00	38.03
ATOM	2252	NE2	GLN A	325	21.178	44.227	23.721	1.00	37.42
ATOM	2253	C	GLN A	325	25.073	47.671	23.446	1.00	23.75
ATOM	2254	O	GLN A	325	25.188	48.557	24.293	1.00	23.87
ATOM	2255	N	GLY A	326	25.916	47.526	22.430	1.00	23.08
ATOM	2256	CA	GLY A	326	27.043	48.428	22.275	1.00	23.27
ATOM	2257	C	GLY A	326	28.025	48.394	23.435	1.00	22.83
ATOM	2258	O	GLY A	326	28.797	49.327	23.621	1.00	21.36
ATOM	2259	N	ARG A	327	28.006	47.317	24.213	1.00	24.94
ATOM	2260	CA	ARG A	327	28.900	47.192	25.361	1.00	27.26
ATOM	2261	CB	ARG A	327	28.134	46.627	26.559	1.00	29.79
ATOM	2262	CG	ARG A	327	27.058	47.569	27.075	1.00	36.59
ATOM	2263	CD	ARG A	327	26.163	46.918	28.119	1.00	41.47
ATOM	2264	NE	ARG A	327	25.082	47.821	28.508	1.00	48.27
ATOM	2265	CZ	ARG A	327	24.011	47.459	29.208	1.00	50.35
ATOM	2266	NH1	ARG A	327	23.869	46.201	29.606	1.00	52.09
ATOM	2267	NH2	ARG A	327	23.076	48.354	29.499	1.00	50.26
ATOM	2268	C	ARG A	327	30.115	46.320	25.068	1.00	26.50
ATOM	2269	O	ARG A	327	31.016	46.196	25.897	1.00	27.91
ATOM	2270	N	VAL A	328	30.137	45.716	23.887	1.00	24.28
ATOM	2271	CA	VAL A	328	31.244	44.860	23.497	1.00	21.47
ATOM	2272	CB	VAL A	328	30.749	43.465	23.088	1.00	20.24
ATOM	2273	CG1	VAL A	328	31.923	42.598	22.686	1.00	18.37
ATOM	2274	CG2	VAL A	328	29.973	42.833	24.236	1.00	18.95
ATOM	2275	C	VAL A	328	31.992	45.476	22.325	1.00	20.97
ATOM	2276	O	VAL A	328	31.440	45.624	21.237	1.00	21.49
ATOM	2277	N	PRO A	329	33.260	45.854	22.543	1.00	18.84
ATOM	2278	CD	PRO A	329	33.969	45.768	23.831	1.00	19.11
ATOM	2279	CA	PRO A	329	34.113	46.461	21.518	1.00	18.46
ATOM	2280	CB	PRO A	329	35.471	46.552	22.211	1.00	17.66
ATOM	2281	CG	PRO A	329	35.095	46.754	23.641	1.00	18.87
ATOM	2282	C	PRO A	329	34.168	45.612	20.246	1.00	18.00
ATOM	2283	O	PRO A	329	34.356	44.390	20.296	1.00	15.48
ATOM	2284	N	ILE A	330	34.001	46.268	19.107	1.00	15.14
ATOM	2285	CA	ILE A	330	34.038	45.571	17.835	1.00	15.79
ATOM	2286	CB	ILE A	330	32.662	45.635	17.129	1.00	15.18
ATOM	2287	CG2	ILE A	330	32.770	45.067	15.733	1.00	13.79
ATOM	2288	CG1	ILE A	330	31.614	44.869	17.941	1.00	15.97
ATOM	2289	CD1	ILE A	330	30.211	44.945	17.348	1.00	16.11
ATOM	2290	C	ILE A	330	35.086	46.148	16.888	1.00	14.82
ATOM	2291	O	ILE A	330	35.266	47.369	16.796	1.00	13.07
ATOM	2292	N	ILE A	331	35.789	45.257	16.200	1.00	13.52
ATOM	2293	CA	ILE A	331	36.780	45.662	15.209	1.00	13.29
ATOM	2294	CB	ILE A	331	38.114	44.896	15.371	1.00	12.04
ATOM	2295	CG2	ILE A	331	39.082	45.301	14.267	1.00	9.01
ATOM	2296	CG1	ILE A	331	38.722	45.191	16.748	1.00	12.74
ATOM	2297	CD1	ILE A	331	40.103	44.564	16.970	1.00	9.69
ATOM	2298	C	ILE A	331	36.154	45.300	13.863	1.00	13.53
ATOM	2299	O	ILE A	331	35.952	44.120	13.568	1.00	14.03
ATOM	2300	N	GLY A	332	35.825	46.317	13.069	1.00	12.79
ATOM	2301	CA	GLY A	332	35.209	46.097	11.770	1.00	11.23
ATOM	2302	C	GLY A	332	36.199	45.784	10.670	1.00	12.17
ATOM	2303	O	GLY A	332	37.187	46.495	10.498	1.00	15.29
ATOM	2304	N	VAL A	333	35.920	44.726	9.912	1.00	14.17
ATOM	2305	CA	VAL A	333	36.789	44.275	8.825	1.00	13.37
ATOM	2306	CB	VAL A	333	37.667	43.082	9.268	1.00	14.07
ATOM	2307	CG1	VAL A	333	38.941	43.040	8.443	1.00	12.39
ATOM	2308	CG2	VAL A	333	37.936	43.148	10.749	1.00	16.53
ATOM	2309	C	VAL A	333	35.962	43.767	7.646	1.00	12.46
ATOM	2310	O	VAL A	333	34.982	43.053	7.836	1.00	11.94
ATOM	2311	N	GLY A	334	36.376	44.104	6.431	1.00	12.77
ATOM	2312	CA	GLY A	334	35.651	43.639	5.264	1.00	13.14
ATOM	2313	C	GLY A	334	35.402	44.690	4.197	1.00	15.69
ATOM	2314	O	GLY A	334	34.449	45.473	4.287	1.00	14.19
ATOM	2315	N	GLY A	335	36.265	44.708	3.184	1.00	14.95
ATOM	2316	CA	GLY A	335	36.111	45.651	2.093	1.00	15.32
ATOM	2317	C	GLY A	335	36.332	47.119	2.412	1.00	16.47
ATOM	2318	O	GLY A	335	35.742	47.983	1.766	1.00	18.02
ATOM	2319	N	VAL A	336	37.162	47.422	3.403	1.00	16.45
ATOM	2320	CA	VAL A	336	37.434	48.817	3.721	1.00	15.37
ATOM	2321	CB	VAL A	336	37.868	48.994	5.185	1.00	16.95
ATOM	2322	CG1	VAL A	336	38.430	50.402	5.396	1.00	17.10
ATOM	2323	CG2	VAL A	336	36.681	48.757	6.104	1.00	15.58
ATOM	2324	C	VAL A	336	38.547	49.313	2.798	1.00	15.63
ATOM	2325	O	VAL A	336	39.664	48.788	2.808	1.00	12.87
ATOM	2326	N	SER A	337	38.235	50.323	1.994	1.00	15.71
ATOM	2327	CA	SER A	337	39.210	50.861	1.054	1.00	17.36
ATOM	2328	CB	SER A	337	38.909	50.320	0.348	1.00	19.55
ATOM	2329	OG	SER A	337	39.881	50.746	1.281	1.00	26.27
ATOM	2330	C	SER A	337	39.225	52.391	1.026	1.00	16.87
ATOM	2331	O	SER A	337	39.985	52.995	0.270	1.00	16.56
ATOM	2332	N	SER A	338	38.392	53.013	1.856	1.00	15.02
ATOM	2333	CA	SER A	338	38.311	54.466	1.895	1.00	14.94
ATOM	2334	CB	SER A	338	37.337	54.958	0.816	1.00	15.62
ATOM	2335	OG	SER A	338	35.993	54.649	1.163	1.00	12.43
ATOM	2336	C	SER A	338	37.836	54.972	3.257	1.00	14.83
ATOM	2337	O	SER A	338	37.402	54.193	4.108	1.00	15.32
ATOM	2338	N	GLY A	339	37.913	56.283	3.451	1.00	13.85
ATOM	2339	CA	GLY A	339	37.466	56.867	4.700	1.00	13.96
ATOM	2340	C	GLY A	339	35.992	56.577	4.911	1.00	14.77
ATOM	2341	O	GLY A	339	35.568	56.266	6.024	1.00	15.11
ATOM	2342	N	GLN A	340	35.205	56.675	3.840	1.00	13.56
ATOM	2343	CA	GLN A	340	33.775	56.410	3.929	1.00	14.73
ATOM	2344	CB	GLN A	340	33.075	56.650	2.583	1.00	14.84
ATOM	2345	CG	GLN A	340	31.606	56.231	2.606	1.00	16.68
ATOM	2346	CD	GLN A	340	30.869	56.527	1.309	1.00	17.07
ATOM	2347	OE1	GLN A	340	30.787	57.678	0.873	1.00	17.10
ATOM	2348	NE2	GLN A	340	30.322	55.487	0.691	1.00	15.72
ATOM	2349	C	GLN A	340	33.521	54.976	4.376	1.00	14.91
ATOM	2350	O	GLN A	340	32.690	54.736	5.258	1.00	15.89
ATOM	2351	N	ASP A	341	34.231	54.027	3.766	1.00	11.85
ATOM	2352	CA	ASP A	341	34.072	52.622	4.129	1.00	12.88
ATOM	2353	CB	ASP A	341	35.014	51.723	3.311	1.00	12.35
ATOM	2354	CG	ASP A	341	34.759	51.806	1.813	1.00	14.51
ATOM	2355	OD1	ASP A	341	33.624	52.149	1.416	1.00	15.79
ATOM	2356	OD2	ASP A	341	35.690	51.512	1.031	1.00	13.03
ATOM	2357	C	ASP A	341	34.385	52.458	5.613	1.00	11.93
ATOM	2358	O	ASP A	341	33.689	51.748	6.336	1.00	11.87
ATOM	2359	N	ALA A	342	35.441	53.124	6.064	1.00	11.66
ATOM	2360	CA	ALA A	342	35.843	53.046	7.460	1.00	11.86
ATOM	2361	CB	ALA A	342	37.183	53.751	7.657	1.00	11.31
ATOM	2362	C	ALA A	342	34.788	53.652	8.381	1.00	12.51
ATOM	2363	O	ALA A	342	34.421	53.052	9.390	1.00	13.16
ATOM	2364	N	LEU A	343	34.295	54.835	8.026	1.00	11.81
ATOM	2365	CA	LEU A	343	33.296	55.518	8.841	1.00	12.88
ATOM	2366	CB	LEU A	343	33.117	56.960	8.355	1.00	12.38
ATOM	2367	CG	LEU A	343	32.210	57.840	9.220	1.00	12.11
ATOM	2368	CD1	LEU A	343	32.755	57.858	10.646	1.00	12.07
ATOM	2369	CD2	LEU A	343	32.137	59.262	8.644	1.00	9.24
ATOM	2370	C	LEU A	343	31.935	54.816	8.893	1.00	13.84
ATOM	2371	O	LEU A	343	31.257	54.864	9.916	1.00	16.26
ATOM	2372	N	GLU A	344	31.517	54.178	7.802	1.00	14.81
ATOM	2373	CA	GLU A	344	30.234	53.483	7.821	1.00	14.29
ATOM	2374	CB	GLU A	344	29.892	52.902	6.447	1.00	15.56
ATOM	2375	CG	GLU A	344	29.631	53.943	5.363	1.00	16.52
ATOM	2376	CD	GLU A	344	29.003	53.345	4.105	1.00	17.36
ATOM	2377	OE1	GLU A	344	29.284	52.169	3.793	1.00	17.77
ATOM	2378	OE2	GLU A	344	28.240	54.056	3.417	1.00	15.41
ATOM	2379	C	GLU A	344	30.291	52.366	8.862	1.00	14.33
ATOM	2380	O	GLU A	344	29.335	52.147	9.608	1.00	14.20
ATOM	2381	N	LYS A	345	31.423	51.669	8.921	1.00	14.34
ATOM	2382	CA	LYS A	345	31.599	50.591	9.888	1.00	15.17
ATOM	2383	CB	LYS A	345	32.865	49.790	9.576	1.00	13.40
ATOM	2384	CG	LYS A	345	32.673	48.774	8.460	1.00	13.33
ATOM	2385	CD	LYS A	345	33.934	47.958	8.217	1.00	10.82
ATOM	2386	CE	LYS A	345	33.622	46.670	7.470	1.00	11.36
ATOM	2387	NZ	LYS A	345	32.935	46.896	6.170	1.00	11.03
ATOM	2388	C	LYS A	345	31.658	51.143	11.308	1.00	15.43
ATOM	2389	O	LYS A	345	31.113	50.547	12.237	1.00	15.78
ATOM	2390	N	ILE A	346	32.312	52.286	11.478	1.00	15.51
ATOM	2391	CA	ILE A	346	32.396	52.903	12.796	1.00	16.19
ATOM	2392	CB	ILE A	346	33.364	54.115	12.787	1.00	16.23
ATOM	2393	CG2	ILE A	346	33.293	54.866	14.117	1.00	14.17
ATOM	2394	CG1	ILE A	346	34.791	53.618	12.528	1.00	15.33
ATOM	2395	CD1	ILE A	346	35.816	54.718	12.423	1.00	16.06
ATOM	2396	C	ILE A	346	30.995	53.344	13.234	1.00	16.44
ATOM	2397	O	ILE A	346	30.582	53.075	14.362	1.00	16.11
ATOM	2398	N	ARG A	347	30.256	54.002	12.343	1.00	15.77
ATOM	2399	CA	ARG A	347	28.899	54.435	12.679	1.00	16.90
ATOM	2400	CB	ARG A	347	28.298	55.277	11.548	1.00	17.76
ATOM	2401	CG	ARG A	347	28.955	56.649	11.348	1.00	18.67
ATOM	2402	CD	ARG A	347	28.227	57.437	10.259	1.00	19.78
ATOM	2403	NE	ARG A	347	26.818	57.633	10.594	1.00	22.78
ATOM	2404	CZ	ARG A	347	26.283	58.796	10.962	1.00	26.59
ATOM	2405	NH1	ARG A	347	27.037	59.889	11.038	1.00	26.85
ATOM	2406	NH2	ARG A	347	24.994	58.864	11.273	1.00	24.22
ATOM	2407	C	ARG A	347	28.007	53.220	12.948	1.00	15.86
ATOM	2408	O	ARG A	347	27.079	53.283	13.748	1.00	15.48
ATOM	2409	N	ALA A	348	28.296	52.109	12.278	1.00	15.92
ATOM	2410	CA	ALA A	348	27.521	50.892	12.471	1.00	15.49
ATOM	2411	CB	ALA A	348	27.792	49.902	11.333	1.00	15.25
ATOM	2412	C	ALA A	348	27.848	50.252	13.820	1.00	15.76
ATOM	2413	O	ALA A	348	27.095	49.401	14.301	1.00	16.58
ATOM	2414	N	GLY A	349	28.966	50.653	14.431	1.00	13.86
ATOM	2415	CA	GLY A	349	29.315	50.098	15.730	1.00	13.25
ATOM	2416	C	GLY A	349	30.759	49.684	15.979	1.00	14.61
ATOM	2417	O	GLY A	349	31.097	49.268	17.088	1.00	15.21
ATOM	2418	N	ALA A	350	31.617	49.797	14.972	1.00	14.16
ATOM	2419	CA	ALA A	350	33.014	49.418	15.134	1.00	16.29
ATOM	2420	CB	ALA A	350	33.637	49.115	13.774	1.00	16.52
ATOM	2421	C	ALA A	350	33.836	50.485	15.843	1.00	17.09
ATOM	2422	O	ALA A	350	33.737	51.674	15.531	1.00	17.36
ATOM	2423	N	SER A	351	34.646	50.051	16.805	1.00	17.54
ATOM	2424	CA	SER A	351	35.515	50.963	17.540	1.00	16.20
ATOM	2425	CB	SER A	351	35.821	50.411	18.932	1.00	15.23
ATOM	2426	OG	SER A	351	34.684	50.491	19.767	1.00	18.04
ATOM	2427	C	SER A	351	36.812	51.112	16.754	1.00	16.11
ATOM	2428	O	SER A	351	37.503	52.131	16.851	1.00	15.72
ATOM	2429	N	LEU A	352	37.127	50.078	15.977	1.00	14.13
ATOM	2430	CA	LEU A	352	38.328	50.046	15.149	1.00	15.05
ATOM	2431	CB	LEU A	352	39.457	49.286	15.859	1.00	13.12
ATOM	2432	CG	LEU A	352	39.909	49.717	17.254	1.00	14.84
ATOM	2433	CD1	LEU A	352	40.771	48.610	17.869	1.00	11.84
ATOM	2434	CD2	LEU A	352	40.674	51.033	17.171	1.00	13.14
ATOM	2435	C	LEU A	352	37.999	49.308	13.857	1.00	13.72
ATOM	2436	O	LEU A	352	37.021	48.565	13.795	1.00	11.22
ATOM	2437	N	VAL A	353	38.820	49.514	12.831	1.00	12.75
ATOM	2438	CA	VAL A	353	38.626	48.828	11.564	1.00	13.86
ATOM	2439	CB	VAL A	353	38.055	49.761	10.470	1.00	15.70
ATOM	2440	CG1	VAL A	353	36.770	50.417	10.960	1.00	14.25
ATOM	2441	CG2	VAL A	353	39.090	50.799	10.071	1.00	13.83
ATOM	2442	C	VAL A	353	39.962	48.281	11.081	1.00	14.67
ATOM	2443	O	VAL A	353	41.024	48.711	11.536	1.00	12.91
ATOM	2444	N	GLN A	354	39.897	47.316	10.172	1.00	14.28
ATOM	2445	CA	GLN A	354	41.089	46.710	9.596	1.00	14.04
ATOM	2446	CB	GLN A	354	41.347	45.307	10.175	1.00	14.77
ATOM	2447	CG	GLN A	354	41.594	45.223	11.678	1.00	15.51
ATOM	2448	CD	GLN A	354	41.763	43.774	12.147	1.00	18.24
ATOM	2449	OE1	GLN A	354	41.00	542.888	11.745	1.00	16.59
ATOM	2450	NE2	GLN A	354	42.756	43.534	13.000	1.00	16.98
ATOM	2451	C	GLN A	354	40.852	46.574	8.100	1.00	14.33
ATOM	2452	O	GLN A	354	39.715	46.634	7.626	1.00	13.37
ATOM	2453	N	LEU A	355	41.931	46.394	7.354	1.00	14.18
ATOM	2454	CA	LEU A	355	41.822	46.213	5.919	1.00	15.51
ATOM	2455	CB	LEU A	355	41.899	47.561	5.188	1.00	13.52
ATOM	2456	CG	LEU A	355	43.166	48.417	5.312	1.00	13.61
ATOM	2457	CD1	LEU A	355	44.262	47.879	4.399	1.00	13.33
ATOM	2458	CD2	LEU A	355	42.838	49.854	4.943	1.00	10.85
ATOM	2459	C	LEU A	355	42.955	45.306	5.482	1.00	16.16
ATOM	2460	O	LEU A	355	43.963	45.176	6.179	1.00	15.14
ATOM	2461	N	TYR A	356	42.775	44.657	4.340	1.00	17.37
ATOM	2462	CA	TYR A	356	43.805	43.785	3.804	1.00	17.28
ATOM	2463	CB	TYR A	356	43.639	42.352	4.333	1.00	16.02
ATOM	2464	CG	TYR A	356	44.703	41.377	3.852	1.00	15.51
ATOM	2465	CD1	TYR A	356	44.774	40.087	4.363	1.00	16.04
ATOM	2466	CE1	TYR A	356	45.714	39.182	3.897	1.00	14.34
ATOM	2467	CD2	TYR A	356	45.611	41.735	2.862	1.00	16.62
ATOM	2468	CE2	TYR A	356	46.551	40.838	2.387	1.00	16.21
ATOM	2469	CZ	TYR A	356	46.597	39.565	2.905	1.00	16.13
ATOM	2470	OH	TYR A	356	47.518	38.669	2.414	1.00	17.60
ATOM	2471	C	TYR A	356	43.739	43.803	2.287	1.00	17.12
ATOM	2472	O	TYR A	356	44.671	44.261	1.629	1.00	18.15
ATOM	2473	N	THR A	357	42.637	43.308	1.738	1.00	16.53
ATOM	2474	CA	THR A	357	42.472	43.250	0.292	1.00	16.40
ATOM	2475	CB	THR A	357	41.059	42.753	−0.080	1.00	16.96
ATOM	2476	OG1	THR A	357	40.868	41.429	0.439	1.00	13.18
ATOM	2477	CG2	THR A	357	40.886	42.727	−1.589	1.00	16.23
ATOM	2478	C	THR A	357	42.731	44.590	−0.401	1.00	15.65
ATOM	2479	O	THR A	357	43.312	44.633	−1.484	1.00	15.49
ATOM	2480	N	ALA A	358	42.307	45.683	0.223	1.00	15.19
ATOM	2481	CA	ALA A	358	42.507	47.002	−0.367	1.00	15.24
ATOM	2482	CB	ALA A	358	41.921	48.070	0.534	1.00	11.12
ATOM	2483	C	ALA A	358	43.995	47.255	−0.584	1.00	16.21
ATOM	2484	O	ALA A	358	44.394	47.872	−1.572	1.00	15.43
ATOM	2485	N	LEU A	359	44.810	46.770	0.348	1.00	16.24
ATOM	2486	CA	LEU A	359	46.255	46.943	0.273	1.00	16.57
ATOM	2487	CB	LEU A	359	46.916	46.409	1.548	1.00	17.72
ATOM	2488	CG	LEU A	359	48.442	46.485	1.620	1.00	17.63
ATOM	2489	CD1	LEU A	359	48.894	47.933	1.559	1.00	17.25
ATOM	2490	CD2	LEU A	359	48.919	45.829	2.908	1.00	18.09
ATOM	2491	C	LEU A	359	46.846	46.239	−0.942	1.00	15.68
ATOM	2492	O	LEU A	359	47.800	46.725	−1.541	1.00	14.17
ATOM	2493	N	THR A	360	46.270	45.099	−1.309	1.00	15.77
ATOM	2494	CA	THR A	360	46.762	44.336	−2.450	1.00	16.61
ATOM	2495	CB	THR A	360	46.189	42.906	−2.454	1.00	16.18
ATOM	2496	OG1	THR A	360	44.804	42.943	−2.829	1.00	17.30
ATOM	2497	CG2	THR A	360	46.331	42.280	−1.068	1.00	10.83
ATOM	2498	C	THR A	360	46.444	44.986	−3.795	1.00	18.77
ATOM	2499	O	THR A	360	47.034	44.628	−4.813	1.00	21.01
ATOM	2500	N	PHE A	361	45.516	45.937	−3.810	1.00	18.81
ATOM	2501	CA	PHE A	361	45.165	46.606	−5.060	1.00	20.17
ATOM	2502	CB	PHE A	361	43.644	46.760	−5.197	1.00	21.09
ATOM	2503	CG	PHE A	361	42.922	45.482	−5.517	1.00	22.40
ATOM	2504	CD1	PHE A	361	42.189	44.821	−4.547	1.00	19.17
ATOM	2505	CD2	PHE A	361	42.988	44.935	−6.791	1.00	24.26
ATOM	2506	CE1	PHE A	361	41.537	43.641	−4.838	1.00	22.16
ATOM	2507	CE2	PHE A	361	42.335	43.748	−7.089	1.00	23.23
ATOM	2508	CZ	PHE A	361	41.609	43.102	−6.109	1.00	22.64
ATOM	2509	C	PHE A	361	45.796	47.988	−5.195	1.00	20.92
ATOM	2510	O	PHE A	361	46.302	48.344	−6.255	1.00	22.01
ATOM	2511	N	TRP A	362	45.769	48.761	−4.116	1.00	22.57
ATOM	2512	CA	TRP A	362	46.286	50.122	−4.144	1.00	23.30
ATOM	2513	CB	TRP A	362	45.259	51.043	−3.480	1.00	24.63
ATOM	2514	CG	TRP A	362	43.846	50.707	−3.893	1.00	28.77
ATOM	2515	CD2	TRP A	362	43.360	50.512	−5.232	1.00	30.31
ATOM	2516	CE2	TRP A	362	42.000	50.158	−5.134	1.00	30.43
ATOM	2517	CE3	TRP A	362	43.945	50.600	−6.501	1.00	30.78
ATOM	2518	CD1	TRP A	362	42.785	50.474	−3.068	1.00	28.42
ATOM	2519	NE1	TRP A	362	41.674	50.141	−3.804	1.00	28.43
ATOM	2520	CZ2	TRP A	362	41.213	49.890	−6.258	1.00	32.37
ATOM	2521	CZ3	TRP A	362	43.163	50.334	−7.616	1.00	31.79
ATOM	2522	CH2	TRP A	362	41.812	49.983	−7.487	1.00	32.17
ATOM	2523	C	TRP A	362	47.667	50.312	−3.514	1.00	22.63
ATOM	2524	O	TRP A	362	48.320	51.334	−3.737	1.00	22.22
ATOM	2525	N	GLY A	363	48.107	49.329	−2.736	1.00	21.03
ATOM	2526	CA	GLY A	363	49.408	49.416	−2.098	1.00	19.14
ATOM	2527	C	GLY A	363	49.417	50.228	−0.817	1.00	19.51
ATOM	2528	O	GLY A	363	48.372	50.693	−0.359	1.00	20.28
ATOM	2529	N	PRO A	364	50.601	50.418	−0.214	1.00	19.32
ATOM	2530	CD	PRO A	364	51.869	49.874	−0.739	1.00	19.56
ATOM	2531	CA	PRO A	364	50.831	51.169	1.026	1.00	19.42
ATOM	2532	CB	PRO A	364	52.349	51.331	1.051	1.00	18.75
ATOM	2533	CG	PRO A	364	52.816	50.041	0.441	1.00	18.97
ATOM	2534	C	PRO A	364	50.110	52.514	1.150	1.00	20.15
ATOM	2535	O	PRO A	364	49.578	52.837	2.210	1.00	21.62
ATOM	2536	N	PRO A	365	50.082	53.317	0.072	1.00	20.37
ATOM	2537	CD	PRO A	365	50.657	53.076	−1.263	1.00	19.69
ATOM	2538	CA	PRO A	365	49.415	54.624	0.118	1.00	19.12
ATOM	2539	CB	PRO A	365	49.567	55.143	−1.311	1.00	19.93
ATOM	2540	CG	PRO A	365	50.829	54.477	−1.787	1.00	20.52
ATOM	2541	C	PRO A	365	47.950	54.588	0.551	1.00	18.92
ATOM	2542	O	PRO A	365	47.412	55.593	1.011	1.00	19.97
ATOM	2543	N	VAL A	366	47.302	53.437	0.411	1.00	18.53
ATOM	2544	CA	VAL A	366	45.895	53.343	0.779	1.00	18.39
ATOM	2545	CB	VAL A	366	45.306	51.950	0.449	1.00	18.99
ATOM	2546	CG1	VAL A	366	45.762	50.925	1.473	1.00	17.14
ATOM	2547	CG2	VAL A	366	43.793	52.032	0.403	1.00	18.85
ATOM	2548	C	VAL A	366	45.680	53.635	2.257	1.00	18.00
ATOM	2549	O	VAL A	366	44.627	54.130	2.653	1.00	19.45
ATOM	2550	N	VAL A	367	46.689	53.341	3.069	1.00	17.67
ATOM	2551	CA	VAL A	367	46.599	53.568	4.506	1.00	17.92
ATOM	2552	CB	VAL A	367	47.845	53.038	5.224	1.00	17.49
ATOM	2553	CG1	VAL A	367	47.685	53.213	6.717	1.00	15.94
ATOM	2554	CG2	VAL A	367	48.069	51.566	4.858	1.00	18.38
ATOM	2555	C	VAL A	367	46.429	55.050	4.844	1.00	18.04
ATOM	2556	O	VAL A	367	45.555	55.418	5.628	1.00	16.97
ATOM	2557	N	GLY A	368	47.269	55.894	4.254	1.00	19.26
ATOM	2558	CA	GLY A	368	47.179	57.320	4.507	1.00	19.38
ATOM	2559	C	GLY A	368	45.899	57.881	3.924	1.00	21.58
ATOM	2560	O	GLY A	368	45.281	58.782	4.500	1.00	20.55
ATOM	2561	N	LYE A	369	45.491	57.331	2.781	1.00	22.53
ATOM	2562	CA	LYE A	369	44.271	57.773	2.110	1.00	22.83
ATOM	2563	CB	LYE A	369	44.059	56.997	0.804	1.00	22.47
ATOM	2564	CG	LYE A	369	43.053	57.659	−0.123	1.00	24.45
ATOM	2565	CD	LYE A	369	42.550	56.727	−1.215	1.00	23.16
ATOM	2566	CE	LYS A	369	41.613	55.684	−0.638	1.00	24.02
ATOM	2567	NZ	LYS A	369	40.829	54.997	−1.695	1.00	24.58
ATOM	2568	C	LYS A	369	43.062	57.564	3.016	1.00	21.99
ATOM	2569	O	LYS A	369	42.264	58.481	3.231	1.00	22.20
ATOM	2570	N	VAL A	370	42.933	56.354	3.549	1.00	19.95
ATOM	2571	CA	VAL A	370	41.814	56.036	4.424	1.00	18.95
ATOM	2572	CB	VAL A	370	41.853	54.559	4.876	1.00	16.89
ATOM	2573	CG1	VAL A	370	40.745	54.297	5.883	1.00	14.26
ATOM	2574	CG2	VAL A	370	41.692	53.643	3.668	1.00	15.62
ATOM	2575	C	VAL A	370	41.795	56.936	5.655	1.00	19.62
ATOM	2576	O	VAL A	370	40.743	57.447	6.041	1.00	18.54
ATOM	2577	N	LYS A	371	42.957	57.134	6.268	1.00	19.57
ATOM	2578	CA	LYS A	371	43.036	57.982	7.449	1.00	20.77
ATOM	2579	CB	LYS A	371	44.437	57.906	8.068	1.00	20.80
ATOM	2580	CG	LYS A	371	44.714	56.573	8.755	1.00	20.84
ATOM	2581	CD	LYS A	371	46.007	56.598	9.547	1.00	20.94
ATOM	2582	CE	LYS A	371	47.211	56.772	8.643	1.00	20.99
ATOM	2583	NZ	LYS A	371	48.475	56.737	9.422	1.00	21.34
ATOM	2584	C	LYS A	371	42.675	59.433	7.142	1.00	20.94
ATOM	2585	O	LYS A	371	41.944	60.067	7.901	1.00	20.23
ATOM	2586	N	ARG A	372	43.181	59.954	6.029	1.00	22.39
ATOM	2587	CA	ARG A	372	42.899	61.332	5.635	1.00	24.04
ATOM	2588	CB	ARG A	372	43.711	61.711	4.392	1.00	25.41
ATOM	2589	CG	ARG A	372	43.497	63.151	3.942	1.00	30.23
ATOM	2590	CD	ARG A	372	44.290	63.505	2.680	1.00	32.89
ATOM	2591	NE	ARG A	372	43.774	62.832	1.487	1.00	37.10
ATOM	2592	CZ	ARG A	372	44.382	61.822	0.871	1.00	36.84
ATOM	2593	NH1	ARG A	372	45.538	61.362	1.331	1.00	37.88
ATOM	2594	NH2	ARG A	372	43.830	61.272	−0.204	1.00	35.98
ATOM	2595	C	ARG A	372	41.410	61.554	5.351	1.00	23.65
ATOM	2596	O	ARG A	372	40.832	62.551	5.785	1.00	23.32
ATOM	2597	N	GLU A	373	40.793	60.626	4.624	1.00	22.04
ATOM	2598	CA	GLU A	373	39.377	60.748	4.290	1.00	21.15
ATOM	2599	CB	GLU A	373	38.990	59.724	3.214	1.00	21.21
ATOM	2600	CG	GLU A	373	39.790	59.861	1.919	1.00	21.35
ATOM	2601	CD	GLU A	373	39.474	58.770	0.908	1.00	24.25
ATOM	2602	OE1	GLU A	373	39.337	57.600	1.318	1.00	27.16
ATOM	2603	OE2	GLU A	373	39.376	59.074	−0.299	1.00	24.09
ATOM	2604	C	GLU A	373	38.517	60.559	5.530	1.00	20.97
ATOM	2605	O	GLU A	373	37.475	61.196	5.675	1.00	23.42
ATOM	2606	N	LEU A	374	38.954	59.684	6.428	1.00	19.50
ATOM	2607	CA	LEU A	374	38.213	59.442	7.655	1.00	19.13
ATOM	2608	CB	LEU A	374	38.885	58.340	8.479	1.00	16.43
ATOM	2609	CG	LEU A	374	38.240	58.031	9.837	1.00	15.24
ATOM	2610	CD1	LEU A	374	36.785	57.640	9.636	1.00	12.59
ATOM	2611	CD2	LEU A	374	39.005	56.911	10.534	1.00	13.82
ATOM	2612	C	LEU A	374	38.157	60.729	8.472	1.00	20.52
ATOM	2613	O	LEU A	374	37.091	61.132	8.939	1.00	22.71
ATOM	2614	N	GLU A	375	39.310	61.367	8.641	1.00	20.39
ATOM	2615	CA	GLU A	375	39.403	62.609	9.399	1.00	23.59
ATOM	2616	CB	GLU A	375	40.846	63.119	9.404	1.00	26.05
ATOM	2617	CG	GLU A	375	41.083	64.272	10.360	1.00	33.07
ATOM	2618	CD	GLU A	375	42.508	64.792	10.310	1.00	37.24
ATOM	2619	OE1	GLU A	375	43.445	63.966	10.363	1.00	39.09
ATOM	2620	OE2	GLU A	375	42.689	66.027	10.229	1.00	41.20
ATOM	2621	C	GLU A	375	38.485	63.679	8.815	1.00	22.79
ATOM	2622	O	GLU A	375	37.710	64.302	9.537	1.00	22.67
ATOM	2623	N	ALA A	376	38.571	63.881	7.503	1.00	22.58
ATOM	2624	CA	ALA A	376	37.740	64.871	6.827	1.00	22.81
ATOM	2625	CB	ALA A	376	38.087	64.926	5.330	1.00	20.94
ATOM	2626	C	ALA A	376	36.260	64.557	7.010	1.00	23.09
ATOM	2627	O	ALA A	376	35.464	65.454	7.283	1.00	25.43
ATOM	2628	N	LEU A	377	35.890	63.286	6.859	1.00	22.26
ATOM	2629	CA	LEU A	377	34.495	62.881	7.016	1.00	21.07
ATOM	2630	CB	LEU A	377	34.316	61.403	6.661	1.00	18.38
ATOM	2631	CG	LEU A	377	34.395	61.099	5.166	1.00	19.86
ATOM	2632	CD1	LEU A	377	34.336	59.603	4.947	1.00	17.99
ATOM	2633	CD2	LEU A	377	33.257	61.809	4.438	1.00	15.21
ATOM	2634	C	LEU A	377	33.982	63.126	8.427	1.00	21.76
ATOM	2635	O	LEU A	377	32.835	63.529	8.610	1.00	20.90
ATOM	2636	N	LEU A	378	34.828	62.872	9.423	1.00	22.73
ATOM	2637	CA	LEU A	378	34.442	63.086	10.814	1.00	23.95
ATOM	2638	CB	LEU A	378	35.567	62.642	11.757	1.00	19.58
ATOM	2639	CG	LEU A	378	35.806	61.133	11.865	1.00	18.89
ATOM	2640	CD1	LEU A	378	37.114	60.854	12.585	1.00	16.40
ATOM	2641	CD2	LEU A	378	34.638	60.484	12.594	1.00	16.69
ATOM	2642	C	LEU A	378	34.114	64.563	11.048	1.00	24.69
ATOM	2643	O	LEU A	378	33.081	64.888	11.633	1.00	24.07
ATOM	2644	N	LYS A	379	34.994	65.449	10.588	1.00	25.59
ATOM	2645	CA	LYS A	379	34.783	66.885	10.747	1.00	29.22
ATOM	2646	CB	LYS A	379	35.977	67.667	10.197	1.00	30.45
ATOM	2647	CG	LYS A	379	37.288	67.406	10.926	1.00	34.68
ATOM	2648	CD	LYS A	379	38.436	68.182	10.296	1.00	36.27
ATOM	2649	CE	LYS A	379	39.747	67.898	11.010	1.00	40.47
ATOM	2650	NZ	LYS A	379	40.904	68.609	10.389	1.00	42.09
ATOM	2651	C	LYS A	379	33.528	67.294	9.993	1.00	30.46
ATOM	2652	O	LYS A	379	32.638	67.951	10.533	1.00	29.89
ATOM	2653	N	GLU A	380	33.475	66.888	8.732	1.00	31.45
ATOM	2654	CA	GLU A	380	32.358	67.186	7.853	1.00	33.02
ATOM	2655	CB	GLU A	380	32.606	66.511	6.502	1.00	34.90
ATOM	2656	CG	GLU A	380	31.467	66.591	5.519	1.00	41.07
ATOM	2657	CD	GLU A	380	31.820	65.940	4.195	1.00	44.70
ATOM	2658	OE1	GLU A	380	30.909	65.725	3.367	1.00	47.15
ATOM	2659	OE2	GLU A	380	33.016	65.649	3.982	1.00	46.06
ATOM	2660	C	GLU A	380	31.013	66.748	8.433	1.00	32.34
ATOM	2661	O	GLU A	380	29.979	67.353	8.144	1.00	31.13
ATOM	2662	N	GLN A	381	31.023	65.708	9.260	1.00	31.07
ATOM	2663	CA	GLN A	381	29.780	65.218	9.846	1.00	31.01
ATOM	2664	CB	GLN A	381	29.695	63.693	9.688	1.00	30.16
ATOM	2665	CG	GLN A	381	29.351	63.272	8.256	1.00	29.66
ATOM	2666	CD	GLN A	381	29.445	61.774	8.025	1.00	30.22
ATOM	2667	OE1	GLN A	381	29.049	60.975	8.872	1.00	29.82
ATOM	2668	NE2	GLN A	381	29.953	61.388	6.858	1.00	30.17
ATOM	2669	C	GLN A	381	29.546	65.632	11.301	1.00	30.95
ATOM	2670	O	GLN A	381	28.634	65.131	11.959	1.00	30.74
ATOM	2671	N	GLY A	382	30.375	66.546	11.796	1.00	30.35
ATOM	2672	CA	GLY A	382	30.210	67.043	13.150	1.00	30.34
ATOM	2673	C	GLY A	382	30.737	66.225	14.311	1.00	30.42
ATOM	2674	O	GLY A	382	30.443	66.539	15.463	1.00	30.46
ATOM	2675	N	PHE A	383	31.507	65.181	14.037	1.00	29.60
ATOM	2676	CA	PHE A	383	32.053	64.371	15.119	1.00	28.66
ATOM	2677	CB	PHE A	383	32.309	62.941	14.644	1.00	26.51
ATOM	2678	CG	PHE A	383	31.065	62.205	14.243	1.00	24.25
ATOM	2679	CD1	PHE A	383	30.798	61.945	12.910	1.00	23.46
ATOM	2680	CD2	PHE A	383	30.163	61.774	15.200	1.00	21.40
ATOM	2681	CE1	PHE A	383	29.654	61.264	12.536	1.00	22.91
ATOM	2682	CE2	PHE A	383	29.021	61.096	14.833	1.00	22.41
ATOM	2683	CZ	PHE A	383	28.765	60.839	13.498	1.00	22.25
ATOM	2684	C	PHE A	383	33.352	64.975	15.641	1.00	29.41
ATOM	2685	O	PHE A	383	34.237	65.332	14.864	1.00	30.63
ATOM	2686	N	GLY A	384	33.460	65.094	16.960	1.00	29.35
ATOM	2687	CA	GLY A	384	34.666	65.646	17.548	1.00	29.12
ATOM	2688	C	GLY A	384	35.834	64.700	17.353	1.00	29.26
ATOM	2689	O	GLY A	384	36.994	65.111	17.356	1.00	30.18
ATOM	2690	N	GLY A	385	35.518	63.422	17.179	1.00	28.99
ATOM	2691	CA	GLY A	385	36.546	62.419	16.978	1.00	27.13
ATOM	2692	C	GLY A	385	35.935	61.062	16.695	1.00	26.35
ATOM	2693	O	GLY A	385	34.713	60.913	16.712	1.00	26.39
ATOM	2694	N	VAL A	386	36.787	60.075	16.435	1.00	25.90
ATOM	2695	CA	VAL A	386	36.348	58.715	16.145	1.00	23.97
ATOM	2696	CB	VAL A	386	37.558	57.756	16.023	1.00	24.97
ATOM	2697	CG1	VAL A	386	37.078	56.317	15.893	1.00	23.00
ATOM	2698	CG2	VAL A	386	38.414	58.143	14.826	1.00	24.99
ATOM	2699	C	VAL A	386	35.431	58.187	17.241	1.00	24.14
ATOM	2700	O	VAL A	386	34.377	57.614	16.961	1.00	23.65
ATOM	2701	N	THR A	387	35.844	58.389	18.488	1.00	24.08
ATOM	2702	CA	THR A	387	35.090	57.929	19.649	1.00	25.04
ATOM	2703	CB	THR A	387	35.730	58.441	20.955	1.00	26.36
ATOM	2704	OG1	THR A	387	37.126	58.116	20.960	1.00	29.95
ATOM	2705	CG2	THR A	387	35.066	57.797	22.161	1.00	24.13
ATOM	2706	C	THR A	387	33.634	58.377	19.624	1.00	24.22
ATOM	2707	O	THR A	387	32.746	57.651	20.062	1.00	24.33
ATOM	2708	N	ASP A	388	33.400	59.577	19.106	1.00	24.01
ATOM	2709	CA	ASP A	388	32.058	60.142	19.034	1.00	23.47
ATOM	2710	CB	ASP A	388	32.150	61.642	18.747	1.00	27.09
ATOM	2711	CG	ASP A	388	32.861	62.399	19.842	1.00	30.40
ATOM	2712	OD1	ASP A	388	33.719	63.251	19.515	1.00	33.28
ATOM	2713	OD2	ASP A	388	32.557	62.147	21.028	1.00	32.49
ATOM	2714	C	ASP A	388	31.195	59.487	17.965	1.00	21.54
ATOM	2715	O	ASP A	388	29.975	59.459	18.079	1.00	20.53
ATOM	2716	N	ALA A	389	31.835	58.969	16.924	1.00	21.30
ATOM	2717	CA	ALA A	389	31.123	58.341	15.821	1.00	19.74
ATOM	2718	CB	ALA A	389	31.935	58.498	14.536	1.00	20.68
ATOM	2719	C	ALA A	389	30.770	56.873	16.035	1.00	18.26
ATOM	2720	O	ALA A	389	29.862	56.356	15.386	1.00	19.21
ATOM	2721	N	ILE A	390	31.485	56.196	16.930	1.00	17.78
ATOM	2722	CA	ILE A	390	31.225	54.778	17.193	1.00	15.62
ATOM	2723	CB	ILE A	390	32.106	54.253	18.358	1.00	15.31
ATOM	2724	CG2	ILE A	390	31.813	52.784	18.613	1.00	12.29
ATOM	2725	CG1	ILE A	390	33.588	54.424	18.013	1.00	15.83
ATOM	2726	CD1	ILE A	390	34.527	54.138	19.169	1.00	14.86
ATOM	2727	C	ILE A	390	29.754	54.510	17.529	1.00	15.04
ATOM	2728	O	ILE A	390	29.250	54.962	18.554	1.00	16.25
ATOM	2729	N	GLY A	391	29.071	53.782	16.651	1.00	15.63
ATOM	2730	CA	GLY A	391	27.671	53.453	16.872	1.00	15.37
ATOM	2731	C	GLY A	391	26.652	54.560	16.631	1.00	15.79
ATOM	2732	O	GLY A	391	25.466	54.374	16.893	1.00	15.96
ATOM	2733	N	ALA A	392	27.097	55.699	16.114	1.00	16.55
ATOM	2734	CA	ALA A	392	26.207	56.836	15.867	1.00	18.78
ATOM	2735	CB	ALA A	392	26.968	57.944	15.133	1.00	16.54
ATOM	2736	C	ALA A	392	24.918	56.504	15.112	1.00	19.86
ATOM	2737	O	ALA A	392	23.880	57.119	15.361	1.00	19.15
ATOM	2738	N	ASP A	393	24.972	55.543	14.191	1.00	20.27
ATOM	2739	CA	ASP A	393	23.777	55.182	13.426	1.00	21.17
ATOM	2740	CB	ASP A	393	24.092	54.124	12.360	1.00	21.34
ATOM	2741	CG	ASP A	393	24.905	54.671	11.196	1.00	25.41
ATOM	2742	OD1	ASP A	393	24.915	55.904	10.981	1.00	24.65
ATOM	2743	OD2	ASP A	393	25.520	53.851	10.479	1.00	26.65
ATOM	2744	C	ASP A	393	22.670	54.642	14.328	1.00	22.02
ATOM	2745	O	ASP A	393	21.487	54.823	14.046	1.00	22.08
ATOM	2746	N	HIS A	394	23.062	53.976	15.410	1.00	22.05
ATOM	2747	CA	HIS A	394	22.107	53.383	16.342	1.00	23.30
ATOM	2748	CB	HIS A	394	22.818	52.342	17.212	1.00	18.42
ATOM	2749	CG	HIS A	394	23.430	51.219	16.431	1.00	18.64
ATOM	2750	CD2	HIS A	394	24.557	51.165	15.680	1.00	15.81
ATOM	2751	ND1	HIS A	394	22.855	49.968	16.347	1.00	15.16
ATOM	2752	CE1	HIS A	394	23.600	49.193	15.580	1.00	15.16
ATOM	2753	NE2	HIS A	394	24.639	49.895	15.163	1.00	16.24
ATOM	2754	C	HIS A	394	21.415	54.406	17.237	1.00	25.83
ATOM	2755	O	HIS A	394	20.373	54.121	17.821	1.00	26.50
ATOM	2756	N	ARG A	395	21.994	55.595	17.344	1.00	28.78
ATOM	2757	CA	ARG A	395	21.428	56.635	18.188	1.00	33.50
ATOM	2758	CB	ARG A	395	22.550	57.376	18.926	1.00	33.09
ATOM	2759	CG	ARG A	395	23.384	56.469	19.829	1.00	34.73
ATOM	2760	CD	ARG A	395	24.289	57.266	20.759	1.00	35.29
ATOM	2761	NE	ARG A	395	25.446	57.851	20.083	1.00	36.20
ATOM	2762	CZ	ARG A	395	26.557	57.184	19.781	1.00	36.50
ATOM	2763	NH1	ARG A	395	27.557	57.804	19.165	1.00	35.10
ATOM	2764	NH2	ARG A	395	26.674	55.900	20.100	1.00	35.17
ATOM	2765	C	ARG A	395	20.568	57.623	17.408	1.00	37.62
ATOM	2766	O	ARG A	395	19.865	58.441	17.996	1.00	39.11
ATOM	2767	N	ARG A	396	20.619	57.543	16.083	1.00	41.81
ATOM	2768	CA	ARG A	396	19.828	58.434	15.245	1.00	45.90
ATOM	2769	CB	ARG A	396	20.541	58.683	13.908	1.00	48.15
ATOM	2770	CG	ARG A	396	20.571	57.500	12.955	1.00	50.79
ATOM	2771	CD	ARG A	396	21.552	57.745	11.810	1.00	52.97
ATOM	2772	NE	ARG A	396	21.368	59.062	11.207	1.00	54.80
ATOM	2773	CZ	ARG A	396	20.262	59.449	10.582	1.00	56.47
ATOM	2774	NH1	ARG A	396	20.179	60.669	10.065	1.00	57.12
ATOM	2775	NH2	ARG A	396	19.240	58.614	10.466	1.00	57.75
ATOM	2776	C	ARG A	396	18.439	57.842	15.007	1.00	47.29
ATOM	2777	O	ARG A	396	17.445	58.588	15.139	1.00	47.81
ATOM	2778	OXT	ARG A	396	18.361	56.637	14.688	1.00	49.38
THR	1		ARG A	396
END