US 7,101,339 B2Grant
Respiration signal measurement apparatus, systems, and methods
Issue Date:2006-09-05
•24 Claims
•3 Drawing Sheets
Abstract
A cardiac rhythm management apparatus and system may include a first sensor to sense an atrial respiration signal, a second sensor to sense a ventricular respiration signal, and a measurement module capable of being communicatively coupled to the first and second sensors to monitor the atrial and ventricular respiration signals and to select a resulting signal as an indication of respiration. An article may cause a machine to implement a method which includes measuring a second signal responsive to a first signal, measuring a third signal responsive to a first signal, determining a respiration-to-cardiac ratio associated with each one of the second and third signals, and providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration.
Metadata
Assignee
- Cardiac Pacemakers, Inc.
Inventors
- Douglas R. Daum
- Qingsheng Zhu
- Avram Scheiner
Application Information
Application Number:US 10/319,794
Filing Date:2002-12-13
Priority Date:2002-12-13
Art Unit:3735
Classifications
IPC:
A61B5/08
Patent Drawings (3 sheets)
Description
Technical Field
[0001] Embodiments of the invention relate generally to biosensors and measurement apparatus, systems, and methods. More particularly, embodiments of the invention relate to measurement apparatus, systems, and methods which can be used to track the respiratory cycle, including, for example, implanted cardiac lead impedance measurement.
Background
[0002] One task that arises during the use of cardiac rhythm management devices, including pacemakers, is that of sensing respiration. Determining the occurrence of respiration can be used to synchronously adapt pacing or defibrillation to the respiratory cycle.
[0003] The ability to operate in synchronism with a respiration signal can be used to advantage in many areas, including but not limited to respiratory sinus arrhythmia (RSA), defibrillation energy thresholds, and minute ventilation. For example, research indicates that pacing without RSA requires a higher number of beats to accomplish the same volume of oxygen delivery. Thus, proper synchronization can improve the efficiency of pulmonary gas exchange. Other research shows that synchronizing a defibrillation shock with expiration may decrease the defibrillation threshold. Finally, an improved respiration signal might provide a greater ventilation-to-cardiac component for more accurate baseline minute ventilation measurement in cases where the ventilation signal is significantly smaller than the cardiac component.
[0004] Conventional methods of sensing respiration involve measuring the impedance which arises between a ventricular lead tip electrode and an indifferent electrode on a pulse generator header. The signal obtained includes a constant component, a respiratory component, and a cardiac stroke component. The respiration component is then separated from the other components by filtering, which creates a time delay between the actual occurrence of respiration and provision of the extracted signal. The delay reduces the ability to fashion therapy according to the synchronous ideal. However, if respiratory signal quality can be improved, the need for filtering might be reduced or even eliminated, allowing cardiac therapy modification to occur in a more truly synchronous fashion.
Summary
[0005] The apparatus, systems, and methods described herein provide the opportunity to detect respiration in a more reliable manner. The essence of the approach involves measuring several impedance signals, and selecting one of the signals, its correlate, or a combination of the signals and/or their correlates to provide an indication of respiration.
[0006] An exemplary apparatus according to one embodiment of the invention may include a first sensor to sense an atrial respiration signal, a second sensor to sense a ventricular respiration signal, and a measurement module coupled to the first and second sensors to monitor the atrial and ventricular respiration signals and to select a resulting signal (e.g., a combination of selected portions of the atrial and ventricular signals) as an indication of respiration.
[0007] An exemplary system according to one embodiment of the invention includes the apparatus coupled to a processor. The system may further include a current generator, an impedance measurement device, and a filter module.
[0008] An exemplary method according to an embodiment of the invention includes measuring a second signal (e.g. an atrial signal) responsive to a first signal (e.g., an injected current), measuring a third signal (e.g., a ventricular signal) responsive to the first signal, determining a respiration-to-cardiac ratio associated with each of the second and third signals, and providing a resulting signal which includes a correlate of one or both of the second and third signals (or selected portions thereof) as an indication of respiration.
[0009] This summary is intended to provide an exemplary overview of the subject matter further described hereinbelow. It is not intended to provide an exhaustive or exclusive explanation of various embodiments of the invention. The Detailed Description which follows provides further information about such embodiments.
Brief Description of the Figures
[0010] FIG. 1 is a schematic block diagram of an apparatus, and article, and a system according to various embodiments of the invention; and
[0011] FIG. 2 is a flow diagram illustrating a method according to an embodiment of the invention.
Detailed Description
[0012] In the following detailed description of various embodiments of the invention, information with respect to making and using the various embodiments, including a best mode of practicing such embodiments, is provided. Thus, reference is made to the accompanying drawings which form a part hereof, and in which are shown by way of illustration, and not of limitation, specific embodiments in which the invention may be practiced. In the drawings, like numerals describe substantially similar components throughout the several views.
[0013] The embodiments illustrated are described in sufficient detail to enable those skilled in the art to practice the teachings disclosed herein. Other embodiments may be utilized and derived therefrom, such that electrical, structural, and logical substitutions and changes may be made without departing from the scope of this disclosure. The following detailed description, therefore, is not to be taken in a limiting sense, and the scope of various embodiments of the invention is defined only by the appended claims, along with the full range of equivalents to which such claims are entitled.
[0014] It is understood that the embodiments described herein may relate to ventricular and/or atrial pacing therapy. Such embodiments may be applied to mammalian hearts, human and otherwise. Embodiments include single chamber, dual chamber, tri-chamber, and quad-chamber applications. It is also understood that the apparatus, systems, and methods provided herein are not limited to implantable devices, and may be used in devices external to the body. Additionally, other devices within and without the area of cardiac rhythm management may employ aspects of the various concepts presented herein without departing from the scope of various embodiments of the invention.
[0015] An apparatus to determine the occurrence of respiration is capable of measuring a quadrapolar impedance signal using multiple electrodes (e.g. atrial ring/tip electrodes) and multiple pacer electrodes (e.g. header/can electrodes) coupled to a measurement module. By providing an alternative mechanism for impedance measurement, with a corresponding selection and/or combination of signals, the ratio of the ventilatory component to the cardiac component in the resulting respiration signal may be improved.
[0016] FIG. 1 is a schematic block diagram of an apparatus, an article, and a system according to various embodiments of the invention. The apparatus 100, which may be included in a cardiac pacer unit 102, includes one or more ports to which sensors can be attached. For example, a first port 104 may be connected to a first sensor 106 (e.g. a right atrial (RA) sensor, including an electrode pair, such as an RA ring electrode 108 and an RA tip electrode 110, disposed in the right atrium 114 of a heart 120) and a second port 122 may be connected to second sensor 124 (e.g., a left ventricular (LV) sensor, including an electrode pair, such as an LV ring electrode 126 and an LV tip electrode 128, disposed within the left ventricle 132). Other ports connected to additional sensors may also be included, such as a third port 134 connected to a third sensor 136 (e.g., a right ventricular (RV) sensor, including an electrode pair, such as an RV ring electrode 138 and an RV tip electrode 140, disposed within the right ventricle 144).
[0017] Given the exemplary sensor set illustrated in FIG. 1 , the first port 104 can be used to sense an atrial respiration signal 148, and the second port 122 can be used to sense a ventricular respiration signal 150. The third port 134 may be used to sense an atrial or a ventricular respiration signal, such as a right ventricular respiration signal 152, if, for example, the second port 122 is used to sense a left ventricular respiration signal 150. Those skilled in the art, upon reading this disclosure, will realize that several other sensing arrangements are also possible.
[0018] The apparatus 100 also includes a measurement module 156 which is capable of being communicatively coupled to each of the ports 104, 122, 134, and which is used to monitor various respiration signals, such as the atrial and ventricular respiration signals 148, 150, 152, previously described. A resulting signal 160, which may include one or more of the sensed/monitored atrial and/or ventricular respiration signals 148, 150, 152, a correlate (e.g. a scaled version) of one or more of the respiration signals 148, 150, 152, or a combination of the signals 148, 150, 152, and/or their correlates, is then selected as an indication of respiration. It is also possible to select a portion of one of the signals 148, 150, 152 and combine it with a portion of another one of the signals 148, 150, 152. For example, the resulting signal 160 may include 65% of an atrial respiration signal 148 added to 32% of a ventricular respiration signal 150, 152, as well as any number of numerous other combinations.
[0019] The measurement module 156 includes an impedance measurement device 164, such as a quadrapolar impedance measurement device, capable of being communicatively coupled to the ports 104, 122, 134, as well as their corresponding sensors 106, 124, 136. The measurement module 156 may also include voltage and/or current measurement circuitry 168, such as an analog-to-digital converter, and/or a filter module 168, such as an analog or digital signal filter. The impedance measurement device 164 is capable of measuring a voltage, such as one of the voltages V1 existing between an electrode 108, 110 coupled to the first port 104 and one of the two pacer electrodes 174, 176, and a voltage existing between an electrode 126, 128 coupled to the second port 122 and one of the two pacer electrodes 174, 176.
[0020] A current injection device 170, such as a current generator, can be used to inject one or more currents 172 between any lead electrode 108, 110, 126, 128, 138, 140 and any pacer electrode, such as a header electrode 174 or a can electrode 176. One or more corresponding voltages V1, V2, arising between another lead electrode and another pacer electrode, can then be measured. Alternatively, voltages may be impressed across various combinations of electrodes, and one or more resulting currents can be measured. Thus, each sensor 106, 124, 136, such as those including the electrode pairs 108, 110, 126, 128, 138, 140, is capable of propagating a current, injected or measured, and impressing or sensing a voltage. A switch 178 may be included in the apparatus 100 and is used to control the distribution of injected currents 172, and/or impressed voltages, as well as the acquisition of the resulting signals 148, 150, 152. Thus, a single current may be injected, or a single voltage may be impressed, resulting in one or more voltages or currents, respectively, which can be sensed.
[0021] It should be noted that the respiration signals 148, 150, 152 form a part of the voltages V1, V2, and may be extracted therefrom. Thus, for example, one respiration signal 148 may be derived from a voltage V1 measured between one of the lead electrodes 108, 110 coupled to the first port 104, and one of the pacer electrodes 174, 176. Similarly, another respiration signal 150 may be derived from a voltage V2 measured between another of the lead electrodes 126, 128 coupled to the second port 122 and one of the pacer electrodes 174, 176.
[0022] It may now be easily understood that the invention also includes a system 180, including the apparatus 100 described above, as well as a processor 182 capable of being communicatively coupled to the apparatus 100. The processor 182 may also be coupled to a memory 184 containing data 186, such as program data, or data acquired via the measurement module 156. The processor 182 may be used to control various elements of the apparatus 100, such as the current injection device 170, the switch 178, and the measurement module 156.
[0023] It should be noted that current injection devices and measured voltages have been used to illustrate specific embodiments of the invention. However, other embodiments may use voltage sources, combinations of voltage and current sources, measured currents and combinations of measured voltages and currents to arrive at the same result, which is the measurement of respiration signals or other signals from which respiration signals can be reliably extracted.
[0024] The apparatus 100, the cardiac pacer unit 102, the ports 104, 122, 134, the sensors 106, 124, 136, the measurement module 156, the impedance measurement device 164, the voltage and/or current measurement circuitry 168, the filter module 168, the current injection device 170, the switch 178, the system 180, the processor 182, and the memory 184 may all be characterized as “modules” herein. Such modules may include hardware circuitry, and/or a processor and/or memory circuits, software program modules, and/or firmware, and combinations thereof, as desired by the architect of the apparatus 100 and the system 180, and as appropriate for particular implementations of various embodiments of the invention.
[0025] One of ordinary skill in the art will understand that the apparatus and systems of the present invention can be applied to systems other than those which include cardiac rhythm management devices, and thus, the invention is not to be so limited. The illustrations of an apparatus 100 and a system 180 are intended to provide a general understanding of the structure of the present invention, and they are not intended to serve as a complete description of all the elements and features of apparatus and systems that might make use of the structures described herein.
[0026] Applications that may include the novel apparatus and systems of the present invention include electronic circuitry used in communication and signal processing circuitry, modems, processor modules, embedded processors, and application-specific modules, including multilayer, multi-chip modules. Such apparatus and systems may further be utilized as sub-components within a variety of electronic systems, including cellular telephones, personal computers, radios, and others.
[0027] FIG. 2 is a flow diagram illustrating a method according to an embodiment of the invention. The method 211 may begin with injecting a first signal, such as by injecting a current, or impressing a voltage, between a lead electrode, such as a tip or ring electrode, and a pacer electrode, such as a can electrode, or a header electrode, at block 221. The method may then continue with measuring a second signal (e.g., a voltage or current) responsive to the first signal at block 225, and measuring a third signal (e.g., a voltage or current) responsive to the first signal at block 231.
[0028] For example, a first signal (e.g., a current ) might be injected between a right atrial ring electrode and a pacer can electrode at block 221. A corresponding voltage (e.g., a second signal, such as a voltage associated with an atrium) between the right atrial tip electrode and the pacer header electrode might then be measured at block 225. Alternatively, or in addition, a current might be injected between a left ventricular ring electrode and a pacer can electrode at block 221. A corresponding voltage (e.g., a third signal, such as a voltage associated with a ventricle) between the left ventricular tip electrode and the pacer header electrode might then be measured at block 231. Of course, multiple voltages arising from the injection of a single current pulse (e.g., the first signal) may also be measured. And, as mentioned previously, voltages may also be impressed, and the resulting currents may be measured. In any case, the measurements at blocks 225 and 231 may be repeated at various frequencies and/or times. For example, frequencies of measurement may occur within a range of about 20 times per second to about 120 times per second.
[0029] The measured signals (e.g., voltages or measured currents arising from impressed voltages) might then be filtered to extract respiratory components, if necessary, at block 235. The method may then continue with determining a respiration-to-cardiac ratio associated with each one of the second and third signals (e.g., the atrial and ventricular respiration signals) at block 241. The signals may be compared and one or the other signal might be scaled, if necessary, at block 245. Scaling may be linear, logarithmic, or by any other well-known method.
[0030] The method may then continue with combining the measured signals (e.g. the second and third signals), such as by addition or multiplication, to produce a combined signal at block 251. Alternatively, or in addition, the original of the second signal, its correlate (e.g., a scaled version), or a portion of the original second signal may be combined with an original of the third signal, its respective correlate (i.e., a scaled version), or a portion of the original third signal at block 251.
[0031] One of the measured signals, their correlates, or selected portions of the signals may be selected as the resulting signal (i.e., the signal chosen to represent the actual occurrence or indication of respiration) at block 255, depending on various parameters associated with the second and third signals. Alternatively, or in addition, the combination of the second and third signals, and/or their correlates may be selected as the resulting signal at block 255. For example, a correlate of the second signal may be selected as an indication of respiration if the respiration-to-cardiac ratio associated with the second signal is greater than the respiration-to-cardiac ratio associated with the third signal. The method may then end, or continue with the injection of signals at block 221, as described above.
[0032] Referring to the methods just described, it should be clear that some embodiments of the present invention may also be realized in the context of computer-executable instructions, such as program modules, being executed by a computer. Generally, program modules may include routines, programs, objects, components, data structures, etc. that perform particular tasks or implement particular abstract data types. As such, any of the modules 100, 102, 104, 106, 122, 124, 134, 136, 156, 164, 168, 170, 178, 180, 182, and 184 described herein may include software operative on one or more processors to perform methods according to the teachings of various embodiments of the present invention.
[0033] One of ordinary skill in the art will understand, upon reading and comprehending this disclosure, the manner in which a software program can be launched from a computer readable medium in a computer-based system to execute the functions defined in the software program. One of ordinary skill in the art will further understand the various programming languages that may be employed to create one or more software programs designed to implement and perform the methods disclosed herein. The programs can be structured in an object-orientated format using an object-oriented language such as Java, Smalltalk, or C++. Alternatively, the programs can be structured in a procedure-orientated format using a procedural language, such as COBOL or C. The software components may communicate using any of a number of mechanisms that are well-known to those skilled in the art, such as application program interfaces (API) or interprocess communication techniques such as the Remote Procedure Call (RPC). However, the teachings of various embodiments of the present invention are not limited to any particular programming language or environment.
[0034] As is evident from the preceding description, and referring back to FIG. 1 , it can be seen that during the operation of the apparatus 100 a processor or control logic 182 may access some form of computer-readable media, such as the memory 184. Thus, a system 180 having an apparatus 100 according to an embodiment of the invention may also include a processor 182 coupled to a memory 184, volatile (e.g., Random Access Memory) or nonvolatile (e.g., a flash memory).
[0035] By way of example and not limitation, computer-readable media may comprise computer storage media and communications media. Computer storage media includes volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage of information such as computer-readable instructions, data structures, program modules or other data. Communications media specifically embodies computer-readable instructions, data structures, program modules or other data in a modulated data signal such as a carrier wave, coded information signal, and/or other transport mechanism, which includes any information delivery media. The term “modulated data signal” means a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal. By way of example and not limitation, communications media also includes wired media such as a wired network or direct-wired connections, and wireless media such as acoustic, optical, radio frequency, infrared and other wireless media. Combinations of any of the above are also included within the scope of computer-readable and/or accessible media.
[0036] Thus, it is now easily understood that another embodiment of the invention may include an article 190 comprising a machine-accessible medium or memory 184 having associated data 186, wherein the data 186, when accessed, results in a machine (e.g. a processor or control logic 182) performing activities such as measuring a second signal responsive to a first signal, measuring a third signal responsive to the first signal, determining a respiration-to-cardiac ratio associated with each one of the second and third signals, and providing a resulting signal including a correlate of a selected one of the second and third signals as an indication of respiration. Other activities may include combining the correlate of the selected one of the second and third signals with a correlate of the other one of the second and third signals. Alternatively, or in addition, such activities may include selecting a correlate of the second signal as an indication of respiration if the respiration-to-cardiac ratio associated with the second signal is greater than the respiration-to-cardiac ratio associated with the third signal. Further, activities may include measuring one or more voltages between an atrial tip electrode and a header electrode after injecting a current between an atrial ring electrode and a can electrode. As noted above, measuring the second signal responsive to the first signal and measuring the third signal responsive to the first signal can be repeated about 20 times per second to about 120 times per second.
[0037] Although specific embodiments have been illustrated and described herein, those of ordinary skill in the art will appreciate that any arrangement which is calculated to achieve the same purpose may be substituted for the specific embodiments shown. This disclosure is intended to cover any and all adaptations or variations of various embodiments of the present invention. It is to be understood that the above Detailed Description has been made in an illustrative fashion, and not a restrictive one. Combinations of the above embodiments, and other embodiments not specifically described herein will be apparent to those of skill in the art upon reviewing the above description. The scope of various embodiments of the invention includes any other applications in which the above structures and methods are used. Therefore, the scope of various embodiments of the invention should be determined with reference to the appended claims, along with the full range of equivalents to which such claims are entitled.
[0038] It is emphasized that the Abstract is provided to comply with 37 C.F.R. §1.72(b) requiring an abstract that will allow the reader to quickly ascertain the nature of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. It should also be noted that in the foregoing Detailed Description, various features may be grouped together in a single embodiment for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the claimed embodiments of the invention require more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment. Thus the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separate preferred embodiment.
Claims
What is claimed is:
1. An apparatus, comprising:
a first port to receive a first respiration signal comprising an atrial respiration signal;
a second port to receive a second respiration signal comprising a ventricular respiration signal; and
a measurement module capable of being communicatively coupled to the first and second ports to monitor the first and second respiration signals and to select a resulting signal based on the atrial and/or ventricular respiration signal as an indication of respiration.
2. The apparatus of claim 1, wherein the measurement module comprises a quadrapolar impedance measurement device capable of being communicatively coupled to the first and second ports.
3. The apparatus of claim 1, wherein the resulting signal includes a selected portion of the first respiration signal.
4. The apparatus of claim 1, wherein the resulting signal includes the first respiration signal.
5. The apparatus of claim 1, wherein the resulting signal comprises a combination of selected portions of the first and second respiration signals.
6. The apparatus of claim 1, further comprising:
a first pair of electrodes coupled to the first port, the first pair of electrodes to be disposed within an atrium; and
a second pair of electrodes coupled to the second port, the second pair of electrodes to be disposed within a ventricle.
7. The apparatus of claim 6, wherein the first and second pairs of electrodes are each capable of propagating an injected current and sensing at least one resulting voltage.
8. A system, comprising:
an apparatus, including a first port to receive a first respiration signal comprising an atrial respiration signal, a second port to receive a second respiration signal comprising a ventricular respiration signal, and a measurement module capable of being communicatively coupled to the first and second ports to monitor the first and second respiration signals and to select a resulting signal based on the atrial and/or ventricular respiration signal as an indication of respiration; and
a processor capable of being communicatively coupled to the apparatus.
9. The system of claim 8, wherein the first respiration signal is derived from a voltage measured between a first lead electrode coupled to the first port and one of two pacer electrodes.
10. The system of claim 9, wherein the second respiration signal is derived from a voltage measured between a second lead electrode coupled to the second port and one of the two pacer electrodes.
11. The system of claim 8, further comprising a current injection device capable of being communicatively coupled to the processor.
12. The system of claim 8, further comprising a filter module capable of being communicatively coupled to the measurement module.
13. The system of claim 8, further comprising:
a quadrapolar impedance measurement device included in the measurement module, the quadrapolar measurement device capable of measuring a voltage existing between an electrode coupled to the first port and one of two pacer electrodes, and a voltage existing between an electrode coupled to the second port and one of the two pacer electrodes.
14. The system of claim 13, wherein the resulting signal comprises a selected portion of the atrial respiration signal added to a selected portion of the ventricular respiration signal.
15. A method, comprising:
measuring a second signal responsive to a first signal;
measuring a third signal responsive to the first signal;
determining a respiration-to-cardiac ratio associated with each one of the second and third signals; and
providing a resulting signal including a correlate of a selected one of the second and third signals as an indication of respiration.
16. The method of claim 15, wherein measuring a second signal responsive to the first signal includes measuring a voltage associated with a ventricle.
17. The method of claim 16, wherein measuring a third signal responsive to the first signal includes measuring a voltage associated with an atrium.
18. The method of claim 15, wherein the first signal is a current.
19. The method of claim 18, comprising:
injecting the first signal between a lead electrode and a can electrode.
20. An article comprising a machine-accessible medium having associated data, wherein the data, when accessed by a machine, results in the machine performing:
measuring a second signal responsive to a first signal;
measuring a third signal responsive to the first signal;
determining a respiration-to-cardiac ratio associated with each one of the second and third signals; and
providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration.
21. The article of claim 20, wherein providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration comprises:
combining the selected portion of the selected one of the second and third signals with a correlate of the other one of the second and third signals.
22. The article of claim 20, wherein providing a resulting signal including a selected portion of a selected one of the second and third signals as an indication of respiration comprises:
selecting a correlate of the second signal as an indication of respiration if the respiration-to-cardiac ratio associated with the second signal is greater than the respiration-to-cardiac ratio associated with the third signal.
23. The article of claim 20, wherein measuring the second signal responsive to the first signal and measuring the third signal responsive to the first signal comprise:
measuring a voltage between an atrial tip electrode and a header electrode after injecting a current between an atrial ring electrode and a can electrode.
24. The article of claim 20, wherein measuring the second signal responsive to the first signal and measuring the third signal responsive to the first signal are each repeated about 20 times per second to about 120 times per second.
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