US 7,053,134 B2Grant
Forming a chemically cross-linked particle of a desired shape and diameter
Issue Date:2006-05-30
•43 Claims
•1 Drawing Sheets
Abstract
Chemically cross-linked polymeric particles are formed using mechanical rather than chemical processes, facilitating production of small-diameter particles in a manner largely independent of the viscosity or density of the polymer. For example, an uncross-linked resin may be provided in particulate form, agglomerated, and compressed into a mass of a desired shape with a desired diameter, and subsequently cross-linked.
Metadata
Assignee
- Scimed Life Systems, Inc.
Inventors
- Samuel P. Baldwin
- Robert P. Skribiski
Application Information
Application Number:US 10/402,068
Filing Date:2003-03-28
Priority Date:2002-04-04
Art Unit:1711
Classifications
IPC:
C08J3/28C08J3/24
Patent Drawings (1 sheets)
Description
Cross-Reference to Related Applications
[0001] This application is a continuation application of and claims priority to U.S. application Ser. No. 10/116,330, filed on Apr. 4, 2002 now abandonded.
Technical Field
[0002] The invention relates generally to forming a chemically cross-linked particle and more particularly to forming a chemically cross-linked particle of a desired shape and diameter.
Background Information
[0003] Polymeric microspheres (i.e., microspheres formed at least in part from a polymer) are used in medical and industrial areas. These microspheres may be used as drug delivery agents, tissue bulking agents, tissue engineering agents, and embolization agents, for example. Accordingly, there are a variety of methods directed towards preparing polymeric microspheres. Typical methods include dispersion polymerization of the monomer, potentiometric dispersion of dissolved polymer within an emulsifying solution followed by solvent evaporation, electrostatically controlled extrusion, and injection of dissolved polymer into an emulsifying solution through a porous membrane followed by solvent evaporation.
[0004] Additional methods of preparing polymeric microspheres include vibratory excitation of a laminar jet of monomeric material flowing in a continuous liquid medium containing a suitable suspending agent, irradiation of slowly thawing frozen monomer drops, emulsification and evaporation, emulsification and evaporation using a high shear air flow, and continuous injection of dissolved polymer into a flowing non-solvent through a needle oriented in parallel to the direction of flow of the non-solvent.
Summary of the Invention
[0005] The present invention facilitates production of microspheres having small diameters in a manner that is generally independent of viscosity and density. This is accomplished through the use of an uncross-linked polymer precursor in solid form, and a mechanical technique of compacting the precursor into a desired shape.
[0006] Accordingly, in one aspect, the invention involves a method of forming a chemically cross-linked particle of a desired shape and diameter. The method includes providing an uncross-linked resin (e.g., polyvinyl alcohol) in particulate form, agglomerating the resin into a mass of a desired shape with a desired diameter, compressing the mass, and cross-linking the mass to thereby form the chemically cross-linked particle. An advantage of the present invention is the ability to avoid melting the resin in order to attain the desired shape. This is useful, for example, in connection with thermally unstable polymers.
[0007] In one embodiment, the method further includes adding a binding agent (such as a starch or a sugar) to the resin and later removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent. The binding agent serves to hold the mass of uncross-linked resin particles together in the desired shape until the mass is cross-linked. In other embodiments, the binding agent comprises a polymer having a melting temperature lower than the melting temperature of the resin. In this way, the polymer becomes part of the chemically cross-linked particle.
[0008] In another embodiment, the method further includes cross-linking the mass by exposing the mass to actinic energy such as an electron beam, ultraviolet radiation, or gamma radiation.
[0009] In still another embodiment, the method further includes cross-linking the mass by exposing the particle to a gaseous cross-linking agent.
[0010] In yet another embodiment, the method further includes agglomerating the resin into a mass in the shape of a sphere with a diameter of less than 600 microns.
[0011] In another aspect, the invention involves a method of forming a chemically cross-linked particle of a desired shape and diameter. The method includes providing an uncross-linked resin in particulate form, adding a binding agent to the resin, and agglomerating the resin into a mass. The method further includes heating the mass to a temperature that is both above the melting point of the binding agent and below the melting point of the resin, compressing the mass into a desired shape with a desired diameter, and cooling the mass to a temperature below the melting point of the binding agent. The mass is then cross-linked to form the chemically cross-linked particle.
[0012] In one embodiment, cross-linking the mass includes exposing the mass to actinic energy, such as an electron beam, ultraviolet radiation, or gamma radiation.
[0013] In another embodiment, cross-linking the mass includes exposing the mass to a gaseous cross-linking agent.
[0014] In still another embodiment, the method further includes removing the binding agent by heating the chemically cross-linked particle to a temperature above the melting point of the binding agent. The binding agent is thereby melted out of the chemically cross-linked particle.
[0015] In yet another embodiment, the method further includes removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
[0016] The foregoing and other objects, aspects, features, and advantages of the invention will become more apparent from the following description and from the claims.
Brief Description of the Drawings
[0017] In the drawings, like reference characters generally refer to the same parts throughout the different views. Also, the drawings are not necessarily to scale, emphasis instead generally being placed upon illustrating the principles of the invention.
[0018] FIG. 1 is an illustrative flow diagram depicting the steps of forming a chemically cross-linked particle of a desired shape and diameter according to one embodiment of the invention.
[0019] FIG. 2 is an illustrative flow diagram depicting the steps of forming a chemically cross-linked particle of a desired shape and diameter according to another embodiment of the invention.
Detailed Description of the Preferred Embodiments
[0020] Referring to FIG. 1 , in one embodiment, the method of forming a chemically cross-linked particle of a desired shape and diameter is a mechanical process rather than a chemical process. First, an uncross-linked resin or polymer in particulate form is provided (Step 102). In one embodiment, the resin is a polyvinyl alcohol resin in particulate form having an average diameter of approximately 75 microns, such as a 99% hydrolyzed polyvinyl alcohol (e.g., product #341584 from Aldrich Chemical or Gohsenol NM-11 from Nippon Synthetic Chemical Industry Co.). In other embodiments, polymers such as polyvinyl acetate, vinyl polymers, polyamides, polyureas, polyurethranes, methacrylates, polyvinyl alcohols, or polymers having a pendant ester group that is easily cross-linked (or derivatives thereof) can be used. For many applications (e.g., embolics), the polymer is desirably hydrophilic.
[0021] A binding agent is then mixed with the resin particles (Step 104). The binding agent serves to hold the resin particles together before they are cross-linked. In some embodiments, the binding agent is a starch or a sugar (e.g., sucrose). In other embodiments, other materials such as alginates, polysaccharides, proteins, carrageenan, or vegetable gums, for example, can be used as binding agents. In still other embodiments, the binding agent can be a blend of one or more of the above synthetic or naturally occurring materials.
[0022] After the uncross-linked resin is mixed with the binding agent, the resin particles are agglomerated into a mass of a desired shape with a desired diameter (Step 106). In one embodiment, the resin particles are forced into a mold (using conventional plastic injection molding techniques) conforming to the desired shape and diameter. In another embodiment, the resin particles are pressed into the desired shape and diameter using conventional compression equipment. In still another embodiment, a punch is used to punch the desired shape out of a solid sheet of the resin. In yet another embodiment, a combination of static electricity and mechanical vibration or agitation is applied to the uncross-linked resin to cause the uncross-linked resin to agglomerate. In another embodiment, the uncross-linked resin particles are agglomerated by being put into a suspension and rotated. Rotation forces the resin particles to collide with each other and form a mass that can thereafter be cross-linked. The size of the mass is selected by controlling the rate of rotation. As the rotation speed increases, so does the number of resin particle collisions. However, the forces acting to pull the agglomerated mass apart also increase. The final size of the mass is a function of rotation speed and the force acting to pull the mass apart.
[0023] Preferably, the technique used to form the particle involves, or is followed by, some form of compression in order to ensure that the resin particles stay together in the desired shape, such as a sphere (Step 108). For example, molding can involve pneumatic, hydraulic, or other compression of the resin-filled mold form. Rotation generally provides adequate compression force.
[0024] After the mass is compressed, it is cross-linked to form the chemically cross-linked particle (Step 110). In some embodiments, cross-linking the mass is accomplished by exposing the mass to actinic energy, such as an electron beam, ultraviolet radiation, or gamma radiation. In other embodiments, cross-linking the mass is accomplished by exposing the mass to a gaseous cross-linking agent such as formaldehyde, glutaraldehyde, or an acid, for example. Polyvinyl alcohol and other polymers can be cross-linked using any of these techniques.
[0025] After the mass is chemically cross-linked and a chemically cross-linked particle is formed, the binding agent may be removed from the particle by exposing the particle to a solvent (Step 112) formulated to selectively dissolve the binding agent. For example, a polar solvent (e.g., water or alcohol) can be used to dissolve the binding agents discussed above.
[0026] Referring to FIG. 2 , in another embodiment, the binding agent is a polymer with a melting temperature that is lower than the melting temperature of the resin. First, an uncross-linked resin or polymer in particulate form is provided (Step 202). Next, a binding agent is added to the resin (204). After the uncross-linked resin is mixed with the binding agent, the resin particles are agglomerated into a mass of a desired shape with a desired diameter (Step 206).
[0027] Exemplary binding agents useful in connection with this embodiment include Methocell methoylcellulose, hydroxypropyl methylcellulose, Ethocell Standard and Premium (organic solvent soluble) from Dow Chemical Co., Avicel PH-001 and Avicell PH-002 microcrystalline cellulose (water soluble) from Asahi Kasei Corp, potassium alginates, sodium alginates, or PEG 1400 (polyethylene glycol), for example. The agglomerated mass of binding agent and resin is heated to a temperature above the binding-agent melting point but below the resin melting point (Step 208). After the mass is heated, it is compressed (Step 210). Compression ensures that the resin particles stay together in the desired shape, such as a sphere, for example. After the mass is compressed, it is cooled (Step 212). Upon cooling, the binding agent resolidifies and the shape imparted to the mass remains “set.”
[0028] After the mass is cooled, it is then cross-linked to form the chemically cross-linked particle (Step 214). The binding agent may remain in the particle during and following cross-linking of the resin. In some embodiments, cross-linking the mass is accomplished by exposing the mass to actinic energy, such as an electron beam, ultraviolet radiation, or gamma radiation. In other embodiments, cross-linking the mass is accomplished by exposing the mass to a gaseous cross-linking agent such as formaldehyde or glutaraldehyde, for example. After the mass is cross-linked, the resulting particle can be again heated to a temperature above the binding-agent melting point so that the binding agent can be melted out of the particle (Step 216). The binding agent may also be removed from the particle by exposing the particle to a solvent formulated to selectively dissolve the binding agent. For example, a polar solvent (e.g. water or alcohol) can be used to dissolve some of binding agents discussed above.
[0029] Variations, modifications, and other implementations of what is described herein may occur to those of ordinary skill in the art without departing from the spirit and scope of the invention. Accordingly, the invention is not to be defined only by the preceding illustrative description.
Claims
The invention claimed is:
1. A method of forming a chemically cross-linked particle, the method comprising:
providing an uncross-linked polyvinyl alcohol resin in particulate form;
agglomerating the resin into a mass;
compressing the mass into a sphere with a diameter of less than 600 microns; and
cross-linking the mass to thereby form the chemically cross-linked particle.
2. The method of claim 1 further comprising the step of adding a binding agent to the resin.
3. The method of claim 2 wherein the step of adding a binding agent comprises adding a starch.
4. The method of claim 2 wherein the step of adding a binding agent comprises adding a sugar.
5. The method of claim 1 wherein the step of cross-linking the mass comprises exposing the mass to actinic energy.
6. The method of claim 5 wherein the step of exposing the mass to actinic energy comprises exposing the mass to one of an electron beam, ultraviolet radiation, and gamma radiation.
7. The method of claim 1 wherein the step of cross-linking the mass comprises exposing the mass to a gaseous cross-linking agent.
8. The method of claim 2 further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
9. A method of forming a chemically cross-linked particle, the method comprising:
providing an uncross-linked resin in particulate form;
adding a binding agent to the resin, the binding agent having a melting point below a melting point of the resin;
agglomerating the resin into a mass;
heating the mass to a temperature above the melting point of the binding agent and below the melting point of the resin;
compressing the mass into a sphere with a diameter of less than 600 microns;
cooling the mass to a temperature below the melting point of the binding agent; and
cross-linking the mass to thereby form the chemically cross-linked particle.
10. The method of claim 9 wherein the binding agent is a polymer, the polymer becoming part of the chemically cross-linked particle.
11. The method of claim 9 wherein the step of cross-linking the mass comprises exposing the mass to actinic energy.
12. The method of claim 11 wherein the step of exposing the mass to actinic energy comprises exposing the mass to one of an electron beam, ultraviolet radiation, and gamma radiation.
13. The method of claim 9 wherein the step of cross-linking the mass comprises exposing the mass to a gaseous cross-linking agent.
14. The method of claim 9 further comprising the step of removing the binding agent by heating the chemically cross-linked particle to a temperature above the melting point of the binding agent thereby melting the binding agent out of the chemically cross-linked particle.
15. The method of claim 9 further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
16. A method of forming a chemically cross-linked spherical particle, the method comprising:
providing in particulate form an uncross-linked resin selected from the group consisting polyvinyl alcohol, polyvinyl acetate, vinyl polymers, polyamides, polyureas, and methacrylates;
agglomerating the resin into a mass;
compressing the mass into a sphere with a diameter of less than 600 microns; and
cross-linking the mass by exposing the mass to radiation, to thereby form the chemically cross-linked spherical particle.
17. The method of claim 16, further comprising the step of adding a binding agent to the resin, wherein the binding agent comprises sucrose.
18. The method of claim 17, further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
19. The method of claim 16, further comprising the step of adding a binding agent to the resin, wherein the binding agent comprises a starch.
20. The method of claim 19, further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
21. The method of claim 16, wherein the step of cross-linking the mass comprises exposing the mass to radiation selected from the group consisting of electron beam radiation, ultraviolet radiation, and gamma radiation.
22. The method of claim 16, wherein the step of cross-linking the mass comprises exposing the mass to formaldehyde or gluturaldehyde.
23. A method of forming a chemically cross-linked particle, the method comprising:
providing an uncross-linked resin in particulate form;
agglomerating the resin into a mass;
compressing the mass into a sphere with a diameter of less than 600 microns; and
exposing the mass to actinic energy to cross-link the mass to thereby form the chemically cross-linked particle.
24. The method of claim 23 further comprising the step of adding a binding agent to the resin.
25. The method of claim 24 wherein the step of adding a binding agent comprises adding a starch.
26. The method of claim 24 wherein the step of adding a binding agent comprises adding a sugar.
27. The method of claim 24 further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
28. The method of claim 23 wherein the step of exposing the mass to actinic energy comprises exposing the mass to one of an electron beam, ultraviolet radiation, and gamma radiation.
29. The method of claim 23 wherein the resin comprises a polyvinyl alcohol resin.
30. A method of forming a chemically cross-linked particle, the method comprising:
providing an uncross-linked resin in particulate form;
agglomerating the resin into a mass;
compressing the mass into a sphere with a diameter of less than 600 microns; and
exposing the mass to a gaseous cross-linking agent to cross-link the mass to thereby form the chemically cross-linked particle.
31. The method of claim 30 further comprising the step of adding a binding agent to the resin.
32. The method of claim 31 wherein the step of adding a binding agent comprises adding a starch.
33. The method of claim 31 wherein the step of adding a binding agent comprises adding a sugar.
34. The method of claim 31 further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
35. The method of claim 30 wherein the resin comprises a polyvinyl alcohol resin.
36. A method of forming a chemically cross-linked particle, the method comprising:
providing an uncross-linked resin in particulate form;
agglomerating the resin into a mass;
compressing the mass into a sphere with a diameter of less than 600 microns; and
cross-linking the mass to thereby form the chemically cross-linked particle.
37. The method of claim 36 further comprising the step of adding a binding agent to the resin.
38. The method of claim 37 wherein the step of adding a binding agent comprises adding a starch.
39. The method of claim 37 wherein the step of adding a binding agent comprises adding a sugar.
40. The method of claim 37 further comprising the step of removing the binding agent by exposing the particle to a solvent formulated to selectively dissolve the binding agent.
41. The method of claim 36 wherein the step of cross-linking the mass comprises exposing the mass to actinic energy.
42. The method of claim 41 wherein the step of exposing the mass to actinic energy comprises exposing the mass to one of an electron beam, ultraviolet radiation, and gamma radiation.
43. The method of claim 36 wherein the step of cross-linking the mass comprises exposing the mass to a gaseous cross-linking agent.
Patent Citations (416)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US2275154(A) | 1942-03-01 | Merrill et al. | Applicant |
| US2609347(A) | 1952-09-01 | Wilson | Applicant |
| US3663470(A) | 1972-05-01 | Nishimura et al. | Applicant |
| US3737398(A) | 1973-06-01 | Yamaguchi | Applicant |
| US3957933(A) | 1976-05-01 | Egli et al. | Applicant |
| US4025686(A) | 1977-05-01 | Zion | Applicant |
| US4034759(A) | 1977-07-01 | Haerr | Applicant |
| US4055377(A) | 1977-10-01 | Erickson et al. | Applicant |
| US4076640(A) | 1978-02-01 | Forgensi et al. | Applicant |
| US4094848(A) | 1978-06-01 | Naito | Applicant |
| US4096230(A) | 1978-06-01 | Haerr | Applicant |
| US4098728(A) | 1978-07-01 | Rosenblatt | Applicant |
| US4110529(A) | 1978-08-01 | Stoy | Applicant |
| US4159719(A) | 1979-07-01 | Haerr | Applicant |
| US4191672(A) | 1980-03-01 | Salome et al. | Applicant |
| US4198318(A) | 1980-04-01 | Stowell et al. | Applicant |
| US4243794(A) | 1981-01-01 | White et al. | Applicant |
| US4246208(A) | 1981-01-01 | Dundas | Applicant |
| US4266030(A) | 1981-05-01 | Tschang et al. | Applicant |
| US4268495(A) | 1981-05-01 | Muxfeldt et al. | Applicant |
| US4271281(A) | 1981-06-01 | Kelley et al. | Applicant |
| US4402319(A) | 1983-09-01 | Handa et al. | Applicant |
| US4413070(A) | 1983-11-01 | Rembaum | Applicant |
| US4427794(A) | 1984-01-01 | Lange et al. | Applicant |
| US4428869(A) | 1984-01-01 | Munteanu et al. | Applicant |
| US4429062(A) | 1984-01-01 | Pasztor et al. | Applicant |
| US4442843(A) | 1984-04-01 | Rasor et al. | Applicant |
| US4444961(A) | 1984-04-01 | Timm | Applicant |
| US4452773(A) | 1984-06-01 | Molday | Applicant |
| US4456693(A) | 1984-06-01 | Welsh | Applicant |
| US4459145(A) | 1984-07-01 | Elsholz | Applicant |
| US4472552(A) | 1984-09-01 | Blouin | Applicant |
| US4477255(A) | 1984-10-01 | Pasztor et al. | Applicant |
| US4492720(A) | 1985-01-01 | Mosier | Applicant |
| US4522953(A) | 1985-06-01 | Barby et al. | Applicant |
| US4542178(A) | 1985-09-01 | Zimmermann et al. | Applicant |
| US4551132(A) | 1985-11-01 | Pasztor et al. | Applicant |
| US4551436(A) | 1985-11-01 | Johnson et al. | Applicant |
| US4573967(A) | 1986-03-01 | Hargrove et al. | Applicant |
| US4622362(A) | 1986-11-01 | Rembaum | Applicant |
| US4623706(A) | 1986-11-01 | Timm et al. | Applicant |
| US4640807(A) | 1987-02-01 | Afghan et al. | Applicant |
| US4657756(A) | 1987-04-01 | Rasor et al. | Applicant |
| US4661137(A) | 1987-04-01 | Garnier et al. | Applicant |
| US4663358(A) | 1987-05-01 | Hyon et al. | Applicant |
| US4671954(A) | 1987-06-01 | Goldberg et al. | Applicant |
| US4674480(A) | 1987-06-01 | Lemelson | Applicant |
| US4675113(A) | 1987-06-01 | Graves et al. | Applicant |
| US4678710(A) | 1987-07-01 | Sakimoto et al. | Applicant |
| US4678814(A) | 1987-07-01 | Rembaum | Applicant |
| US4680320(A) | 1987-07-01 | Uku et al. | Applicant |
| US4681119(A) | 1987-07-01 | Rasor et al. | Applicant |
| US4695466(A) | 1987-09-01 | Morishita et al. | Applicant |
| US4713076(A) | 1987-12-01 | Draenert | Applicant |
| US4742086(A) | 1988-05-01 | Masamizu et al. | Applicant |
| US4743507(A) | 1988-05-01 | Franses et al. | Applicant |
| US4772635(A) | 1988-09-01 | Mitschker et al. | Applicant |
| US4782097(A) | 1988-11-01 | Jain et al. | Applicant |
| US4789501(A) | 1988-12-01 | Day et al. | Applicant |
| US4793980(A) | 1988-12-01 | Torobin | Applicant |
| US4795741(A) | 1989-01-01 | Leshchiner et al. | Applicant |
| US4801458(A) | 1989-01-01 | Hidaka et al. | Applicant |
| US4804366(A) | 1989-02-01 | Zdeb et al. | Applicant |
| US4819637(A) | 1989-04-01 | Dormandy, Jr. et al. | Applicant |
| US4822535(A) | 1989-04-01 | Ekman et al. | Applicant |
| US4833237(A) | 1989-05-01 | Kawamura et al. | Applicant |
| US4850978(A) | 1989-07-01 | Dudar et al. | Applicant |
| US4859711(A) | 1989-08-01 | Jain et al. | Applicant |
| US4863972(A) | 1989-09-01 | Itagaki et al. | Examiner |
| US4897255(A) | 1990-01-01 | Fritzberg et al. | Applicant |
| US4929400(A) | 1990-05-01 | Rembaum et al. | Applicant |
| US4933372(A) | 1990-06-01 | Feibush et al. | Applicant |
| US4946899(A) | 1990-08-01 | Kennedy et al. | Applicant |
| US4954399(A) | 1990-09-01 | Tani et al. | Applicant |
| US4981625(A) | 1991-01-01 | Rhim et al. | Applicant |
| US4990340(A) | 1991-02-01 | Hidaka et al. | Applicant |
| US4999188(A) | 1991-03-01 | Solodovnik et al. | Applicant |
| US5007940(A) | 1991-04-01 | Berg | Applicant |
| US5011677(A) | 1991-04-01 | Day et al. | Applicant |
| USH915(H) | 1991-05-01 | Gibbs | Applicant |
| US5015423(A) | 1991-05-01 | Eguchi et al. | Applicant |
| US5032117(A) | 1991-07-01 | Motta | Applicant |
| US5034324(A) | 1991-07-01 | Shinozaki et al. | Applicant |
| US5047438(A) | 1991-09-01 | Feibush et al. | Applicant |
| US5079274(A) | 1992-01-01 | Schneider et al. | Applicant |
| US5091205(A) | 1992-02-01 | Fan | Applicant |
| US5106903(A) | 1992-04-01 | Vanderhoff et al. | Applicant |
| US5114421(A) | 1992-05-01 | Polak | Applicant |
| US5116387(A) | 1992-05-01 | Berg | Applicant |
| US5120349(A) | 1992-06-01 | Stewart et al. | Applicant |
| US5125892(A) | 1992-06-01 | Drudik | Applicant |
| US5147631(A) | 1992-09-01 | Glajch et al. | Applicant |
| US5147937(A) | 1992-09-01 | Frazza et al. | Applicant |
| US5149543(A) | 1992-09-01 | Cohen et al. | Applicant |
| US5158573(A) | 1992-10-01 | Berg | Applicant |
| US5171214(A) | 1992-12-01 | Kolber et al. | Applicant |
| US5171217(A) | 1992-12-01 | March et al. | Applicant |
| US5181921(A) | 1993-01-01 | Makita et al. | Applicant |
| US5190760(A) | 1993-03-01 | Baker | Examiner |
| US5190766(A) | 1993-03-01 | Ishihara | Applicant |
| US5192301(A) | 1993-03-01 | Kamiya et al. | Applicant |
| US5202352(A) | 1993-04-01 | Okada et al. | Applicant |
| US5216096(A) | 1993-06-01 | Hattori et al. | Applicant |
| US5253991(A) | 1993-10-01 | Yokota et al. | Applicant |
| US5260002(A) | 1993-11-01 | Wang | Applicant |
| US5262176(A) | 1993-11-01 | Palmacci et al. | Applicant |
| US5263992(A) | 1993-11-01 | Guire | Applicant |
| US5288763(A) | 1994-02-01 | Li et al. | Applicant |
| US5292814(A) | 1994-03-01 | Bayer et al. | Applicant |
| US5302369(A) | 1994-04-01 | Day et al. | Applicant |
| US5314974(A) | 1994-05-01 | Ito et al. | Applicant |
| US5316774(A) | 1994-05-01 | Eury et al. | Applicant |
| USRE34640(E) | 1994-06-01 | Kennedy et al. | Applicant |
| US5320639(A) | 1994-06-01 | Rudnick | Applicant |
| US5328936(A) | 1994-07-01 | Leifholtz et al. | Applicant |
| US5336263(A) | 1994-08-01 | Ersek et al. | Applicant |
| US5344452(A) | 1994-09-01 | Lemperle | Applicant |
| US5344867(A) | 1994-09-01 | Morgan et al. | Applicant |
| US5354290(A) | 1994-10-01 | Gross | Applicant |
| US5369133(A) | 1994-11-01 | Ihm et al. | Applicant |
| US5369163(A) | 1994-11-01 | Chiou et al. | Applicant |
| US5382260(A) | 1995-01-01 | Dormandy, Jr. et al. | Applicant |
| US5384124(A) | 1995-01-01 | Courteille et al. | Applicant |
| US5397303(A) | 1995-03-01 | Sancoff et al. | Applicant |
| US5398851(A) | 1995-03-01 | Sancoff et al. | Applicant |
| US5403870(A) | 1995-04-01 | Gross | Applicant |
| US5417982(A) | 1995-05-01 | Modi | Applicant |
| US5431174(A) | 1995-07-01 | Knute | Applicant |
| US5435645(A) | 1995-07-01 | Faccioli et al. | Applicant |
| US5443495(A) | 1995-08-01 | Buscemi et al. | Applicant |
| US5456693(A) | 1995-10-01 | Conston et al. | Applicant |
| US5468801(A) | 1995-11-01 | Antonelli et al. | Applicant |
| US5469854(A) | 1995-11-01 | Unger et al. | Applicant |
| US5476472(A) | 1995-12-01 | Dormandy, Jr. et al. | Applicant |
| US5484584(A) | 1996-01-01 | Wallace et al. | Applicant |
| US5490984(A) | 1996-02-01 | Freed | Applicant |
| US5494682(A) | 1996-02-01 | Cohen et al. | Applicant |
| US5494940(A) | 1996-02-01 | Unger et al. | Applicant |
| US5512604(A) | 1996-04-01 | Demopolis | Applicant |
| US5514090(A) | 1996-05-01 | Kriesel et al. | Applicant |
| US5525334(A) | 1996-06-01 | Ito et al. | Applicant |
| US5534589(A) | 1996-07-01 | Hager et al. | Applicant |
| US5541031(A) | 1996-07-01 | Yamashita et al. | Applicant |
| US5542935(A) | 1996-08-01 | Unger et al. | Applicant |
| US5553741(A) | 1996-09-01 | Sancoff et al. | Applicant |
| US5556391(A) | 1996-09-01 | Cercone et al. | Applicant |
| US5556610(A) | 1996-09-01 | Yan et al. | Applicant |
| US5558255(A) | 1996-09-01 | Sancoff et al. | Applicant |
| US5558822(A) | 1996-09-01 | Gitman et al. | Applicant |
| US5558856(A) | 1996-09-01 | Klaveness et al. | Applicant |
| US5559266(A) | 1996-09-01 | Klaveness et al. | Applicant |
| US5567415(A) | 1996-10-01 | Porter | Applicant |
| US5569193(A) | 1996-10-01 | Hofstetter et al. | Applicant |
| US5569449(A) | 1996-10-01 | Klaveness et al. | Applicant |
| US5569468(A) | 1996-10-01 | Modi | Applicant |
| US5571182(A) | 1996-11-01 | Ersek et al. | Applicant |
| US5580575(A) | 1996-12-01 | Unger et al. | Applicant |
| US5583162(A) | 1996-12-01 | Li et al. | Applicant |
| US5585112(A) | 1996-12-01 | Unger et al. | Applicant |
| US5595821(A) | 1997-01-01 | Hager et al. | Applicant |
| US5622657(A) | 1997-04-01 | Takada et al. | Applicant |
| US5624685(A) | 1997-04-01 | Takahashi et al. | Applicant |
| US5635215(A) | 1997-06-01 | Boschetti et al. | Applicant |
| US5637087(A) | 1997-06-01 | O'Neil et al. | Applicant |
| US5639710(A) | 1997-06-01 | Lo et al. | Applicant |
| US5648095(A) | 1997-07-01 | Illum et al. | Applicant |
| US5648100(A) | 1997-07-01 | Boschetti et al. | Applicant |
| US5650116(A) | 1997-07-01 | Thompson | Applicant |
| US5651990(A) | 1997-07-01 | Takada et al. | Applicant |
| US5653922(A) | 1997-08-01 | Li et al. | Applicant |
| US5657756(A) | 1997-08-01 | Vrba | Applicant |
| US5681576(A) | 1997-10-01 | Henry | Applicant |
| US5695480(A) | 1997-12-01 | Evans et al. | Applicant |
| US5695740(A) | 1997-12-01 | Porter | Applicant |
| US5698271(A) | 1997-12-01 | Liberti et al. | Applicant |
| US5701899(A) | 1997-12-01 | Porter | Applicant |
| US5715824(A) | 1998-02-01 | Unger et al. | Applicant |
| US5716981(A) | 1998-02-01 | Hunter et al. | Applicant |
| US5718884(A) | 1998-02-01 | Klaveness et al. | Applicant |
| US5723269(A) | 1998-03-01 | Akagi et al. | Applicant |
| US5725534(A) | 1998-03-01 | Rasmussen | Applicant |
| US5733925(A) | 1998-03-01 | Kunz et al. | Applicant |
| US5741331(A) | 1998-04-01 | Pinchuk | Applicant |
| US5746734(A) | 1998-05-01 | Dormandy, Jr. et al. | Applicant |
| US5752974(A) | 1998-05-01 | Rhee et al. | Applicant |
| US5756127(A) | 1998-05-01 | Grisoni et al. | Applicant |
| US5760097(A) | 1998-06-01 | Li et al. | Applicant |
| US5766147(A) | 1998-06-01 | Sancoff et al. | Applicant |
| US5770222(A) | 1998-06-01 | Unger et al. | Applicant |
| US5779668(A) | 1998-07-01 | Grabenkort | Applicant |
| US5785642(A) | 1998-07-01 | Wallace et al. | Applicant |
| US5785682(A) | 1998-07-01 | Grabenkort | Applicant |
| US5792478(A) | 1998-08-01 | Lawin et al. | Applicant |
| US5795562(A) | 1998-08-01 | Klaveness et al. | Applicant |
| US5797953(A) | 1998-08-01 | Tekulve | Applicant |
| US5807323(A) | 1998-09-01 | Kriesel et al. | Applicant |
| US5813411(A) | 1998-09-01 | Van Bladel et al. | Applicant |
| US5823198(A) | 1998-10-01 | Jones et al. | Applicant |
| US5827502(A) | 1998-10-01 | Klaveness et al. | Applicant |
| US5827531(A) | 1998-10-01 | Morrison et al. | Applicant |
| US5830178(A) | 1998-11-01 | Jones et al. | Applicant |
| US5833361(A) | 1998-11-01 | Funk | Applicant |
| US5840387(A) | 1998-11-01 | Berlowitz-Tarrant et al. | Applicant |
| US5846518(A) | 1998-12-01 | Yan et al. | Applicant |
| US5853752(A) | 1998-12-01 | Unger et al. | Applicant |
| US5855615(A) | 1999-01-01 | Bley et al. | Applicant |
| US5863957(A) | 1999-01-01 | Li et al. | Applicant |
| US5876372(A) | 1999-03-01 | Grabenkort et al. | Applicant |
| US5877224(A) | 1999-03-01 | Brocchini et al. | Applicant |
| US5885216(A) | 1999-03-01 | Evans, III et al. | Applicant |
| US5885547(A) | 1999-03-01 | Gray | Applicant |
| US5888546(A) | 1999-03-01 | Ji et al. | Applicant |
| US5888930(A) | 1999-03-01 | Smith et al. | Applicant |
| US5891155(A) | 1999-04-01 | Irie | Applicant |
| US5894022(A) | 1999-04-01 | Ji et al. | Applicant |
| US5895398(A) | 1999-04-01 | Wensel et al. | Applicant |
| US5895411(A) | 1999-04-01 | Irie | Applicant |
| US5899877(A) | 1999-05-01 | Leibitzki et al. | Applicant |
| US5902832(A) | 1999-05-01 | Van Bladel et al. | Applicant |
| US5902834(A) | 1999-05-01 | Porrvik | Applicant |
| US5922025(A) | 1999-07-01 | Hubbard | Applicant |
| US5922304(A) | 1999-07-01 | Unger | Applicant |
| US5928626(A) | 1999-07-01 | Klaveness et al. | Applicant |
| US5935553(A) | 1999-08-01 | Unger et al. | Applicant |
| US5951160(A) | 1999-09-01 | Ronk | Applicant |
| US5957848(A) | 1999-09-01 | Sutton et al. | Applicant |
| US5959073(A) | 1999-09-01 | Schlameus et al. | Applicant |
| US6003566(A) | 1999-12-01 | Thibault et al. | Applicant |
| US6015546(A) | 2000-01-01 | Sutton et al. | Applicant |
| US6027472(A) | 2000-02-01 | Kriesel et al. | Applicant |
| US6028066(A) | 2000-02-01 | Unger | Applicant |
| US6047861(A) | 2000-04-01 | Vidal et al. | Applicant |
| US6048908(A) | 2000-04-01 | Kitagawa | Applicant |
| US6051247(A) | 2000-04-01 | Hench et al. | Applicant |
| US6056721(A) | 2000-05-01 | Shulze | Applicant |
| US6059766(A) | 2000-05-01 | Greff | Applicant |
| US6063068(A) | 2000-05-01 | Fowles et al. | Applicant |
| US6071495(A) | 2000-06-01 | Unger et al. | Applicant |
| US6071497(A) | 2000-06-01 | Steiner et al. | Applicant |
| US6073759(A) | 2000-06-01 | Lamborne et al. | Applicant |
| US6090925(A) | 2000-07-01 | Woiszwillo et al. | Applicant |
| US6096344(A) | 2000-08-01 | Liu et al. | Applicant |
| US6099064(A) | 2000-08-01 | Lund | Applicant |
| US6099864(A) | 2000-08-01 | Morrison et al. | Applicant |
| US6100306(A) | 2000-08-01 | Li et al. | Applicant |
| US6139963(A) | 2000-10-01 | Fujii et al. | Applicant |
| US6149623(A) | 2000-11-01 | Reynolds | Applicant |
| US6160084(A) | 2000-12-01 | Langer et al. | Applicant |
| US6162377(A) | 2000-12-01 | Ghosh et al. | Applicant |
| US6165193(A) | 2000-12-01 | Greene, Jr. et al. | Applicant |
| US6179817(B1) | 2001-01-01 | Zhong | Applicant |
| US6191193(B1) | 2001-02-01 | Lee et al. | Applicant |
| US6214331(B1) | 2001-04-01 | Vanderhoff et al. | Applicant |
| US6214384(B1) | 2001-04-01 | Pallado et al. | Applicant |
| US6224630(B1) | 2001-05-01 | Bao et al. | Applicant |
| US6224794(B1) | 2001-05-01 | Amsden et al. | Applicant |
| US6235224(B1) | 2001-05-01 | Mathiowitz et al. | Applicant |
| US6238403(B1) | 2001-05-01 | Greene, Jr. et al. | Applicant |
| US6245090(B1) | 2001-06-01 | Gilson et al. | Applicant |
| US6251661(B1) | 2001-06-01 | Urabe et al. | Applicant |
| US6258338(B1) | 2001-07-01 | Gray | Applicant |
| US6261585(B1) | 2001-07-01 | Sefton et al. | Applicant |
| US6264861(B1) | 2001-07-01 | Tavernier et al. | Applicant |
| US6267154(B1) | 2001-07-01 | Felicelli et al. | Applicant |
| US6268053(B1) | 2001-07-01 | Woiszwillo et al. | Applicant |
| US6277392(B1) | 2001-08-01 | Klein | Applicant |
| US6280457(B1) | 2001-08-01 | Wallace et al. | Applicant |
| US6291605(B1) | 2001-09-01 | Freeman et al. | Applicant |
| US6296604(B1) | 2001-10-01 | Garibaldi et al. | Applicant |
| US6296622(B1) | 2001-10-01 | Kurz et al. | Applicant |
| US6296632(B1) | 2001-10-01 | Luscher et al. | Applicant |
| US6306418(B1) | 2001-10-01 | Bley | Applicant |
| US6306419(B1) | 2001-10-01 | Vachon et al. | Applicant |
| US6306425(B1) | 2001-10-01 | Tice et al. | Applicant |
| US6306427(B1) | 2001-10-01 | Annonier et al. | Examiner |
| US6312407(B1) | 2001-11-01 | Zadno-Azizi et al. | Applicant |
| US6312942(B1) | 2001-11-01 | Plüss-Wenzinger et al. | Applicant |
| US6315709(B1) | 2001-11-01 | Garibaldi et al. | Applicant |
| US6335384(B1) | 2002-01-01 | Evans et al. | Applicant |
| US6344182(B1) | 2002-02-01 | Sutton et al. | Applicant |
| US6355275(B1) | 2002-03-01 | Klein | Applicant |
| US6368658(B1) | 2002-04-01 | Schwarz et al. | Applicant |
| US6379373(B1) | 2002-04-01 | Sawhney et al. | Applicant |
| US6388043(B1) | 2002-05-01 | Langer et al. | Applicant |
| US6394965(B1) | 2002-05-01 | Klein | Applicant |
| US6423332(B1) | 2002-07-01 | Huxel et al. | Applicant |
| US6432437(B1) | 2002-08-01 | Hubbard | Applicant |
| US6436112(B1) | 2002-08-01 | Wensel et al. | Applicant |
| US6443941(B1) | 2002-09-01 | Slepian et al. | Applicant |
| US6458296(B1) | 2002-10-01 | Heinzen et al. | Applicant |
| US6476069(B1) | 2002-11-01 | Krall et al. | Applicant |
| US6495155(B1) | 2002-12-01 | Tice et al. | Applicant |
| US6544503(B1) | 2003-04-01 | Vanderhoff et al. | Applicant |
| US6544544(B1) | 2003-04-01 | Hunter et al. | Applicant |
| US6545097(B1) | 2003-04-01 | Pinchuk et al. | Applicant |
| US6575896(B1) | 2003-06-01 | Silverman et al. | Applicant |
| US6602261(B1) | 2003-08-01 | Greene, Jr. et al. | Applicant |
| US6602524(B1) | 2003-08-01 | Batich et al. | Applicant |
| US6605111(B1) | 2003-08-01 | Bose et al. | Applicant |
| US6629947(B1) | 2003-10-01 | Sahatjian et al. | Applicant |
| US6632531(B1) | 2003-10-01 | Blankenship | Applicant |
| US6652883(B1) | 2003-11-01 | Goupil et al. | Applicant |
| US6680046(B1) | 2004-01-01 | Boschetti | Applicant |
| US6699222(B1) | 2004-03-01 | Jones et al. | Applicant |
| US2001/0001835(A1) | 2001-05-01 | Greene, Jr. et al. | Applicant |
| US2001/0016210(A1) | 2001-08-01 | Mathiowitz et al. | Applicant |
| US2001/0036451(A1) | 2001-11-01 | Goupil et al. | Applicant |
| US2001/0051670(A1) | 2001-12-01 | Goupil et al. | Applicant |
| US2002/0054912(A1) | 2002-05-01 | Kim et al. | Applicant |
| US2002/0061954(A1) | 2002-05-01 | Davis et al. | Applicant |
| US2002/0160109(A1) | 2002-10-01 | Yeo et al. | Applicant |
| US2002/0182190(A1) | 2002-12-01 | Naimark et al. | Applicant |
| US2002/0197208(A1) | 2002-12-01 | Ruys et al. | Applicant |
| US2003/0007928(A1) | 2003-01-01 | Gray | Applicant |
| US2003/0032935(A1) | 2003-02-01 | Damiano et al. | Applicant |
| US2003/0108614(A1) | 2003-06-01 | Volkonsky et al. | Applicant |
| US2003/0183962(A1) | 2003-10-01 | Buiser et al. | Applicant |
| US2003/0185895(A1) | 2003-10-01 | Lanphere et al. | Applicant |
| US2003/0185896(A1) | 2003-10-01 | Buiser et al. | Applicant |
| US2003/0187320(A1) | 2003-10-01 | Freyman | Applicant |
| US2003/0194390(A1) | 2003-10-01 | Krall et al. | Applicant |
| US2003/0206864(A1) | 2003-11-01 | Mangin | Applicant |
| US2003/0233150(A1) | 2003-12-01 | Bourne et al. | Applicant |
| US2004/0076582(A1) | 2004-04-01 | DiMatteo et al. | Applicant |
| US2004/0091543(A1) | 2004-05-01 | Bell et al. | Applicant |
| US2004/0092883(A1) | 2004-05-01 | Casey et al. | Applicant |
| US2004/0096662(A1) | 2004-05-01 | Lanphere et al. | Applicant |
| US2004/0101564(A1) | 2004-05-01 | Rioux et al. | Applicant |
| US2004/0186377(A1) | 2004-09-01 | Zhong et al. | Applicant |
| US2005/0025800(A1) | 2005-02-01 | Tan | Applicant |
| US2005/0037047(A1) | 2005-02-01 | Song | Applicant |
| AUA-76186/98 | 1998-10-01 | Applicant | |
| DE3834705 | 1990-04-01 | Applicant | |
| DE9414868.6 | 1994-09-01 | Applicant | |
| DE9414868 | 1995-02-01 | Applicant | |
| DE9414868.6 | 1995-02-01 | Applicant | |
| DE10026620 | 2000-05-01 | Applicant | |
| DE29724255(U1) | 2000-10-01 | Applicant | |
| DE10026620A1 | 2002-03-01 | Applicant | |
| EP67459(A1) | 1982-12-01 | Applicant | |
| EP122624 | 1984-10-01 | Applicant | |
| EP123235 | 1984-10-01 | Applicant | |
| EP243165 | 1987-10-01 | Applicant | |
| EP294206 | 1988-12-01 | Applicant | |
| EP402031 | 1990-05-01 | Applicant | |
| EP422258 | 1991-04-01 | Applicant | |
| EP458745(A1) | 1991-05-01 | Applicant | |
| EP458079(A2) | 1991-11-01 | Applicant | |
| EP470569(A1) | 1992-02-01 | Applicant | |
| EP547530(B1) | 1993-06-01 | Applicant | |
| EP600529(A) | 1993-12-01 | Applicant | |
| EP623012(B1) | 1994-11-01 | Applicant | |
| EP706376(B1) | 1996-04-01 | Applicant | |
| EP730847(A1) | 1996-09-01 | Applicant | |
| EP744940(B1) | 1996-12-01 | Applicant | |
| EP797988(A2) | 1997-10-01 | Applicant | |
| EP67459(B2) | 1998-10-01 | Applicant | |
| EP764047 | 2003-08-01 | Applicant | |
| EP993337 | 2004-04-01 | Applicant | |
| ES2096521 | 1997-03-01 | Applicant | |
| JP59-196738 | 1884-11-01 | Applicant | |
| JP62-45637 | 1987-02-01 | Applicant | |
| JP4-74117 | 1992-03-01 | Applicant | |
| JP6-57012 | 1994-03-01 | Applicant | |
| JP9-110678 | 1997-04-01 | Applicant | |
| JP9-165328 | 1997-06-01 | Applicant | |
| JP9-316271 | 1997-12-01 | Applicant | |
| JP10-130329 | 1998-05-01 | Applicant | |
| JP2000189511 | 2000-07-01 | Applicant | |
| JP2001079011 | 2001-03-01 | Applicant | |
| JP2002017848 | 2002-01-01 | Applicant | |
| NZ255409 | 1997-02-01 | Applicant | |
| NZ517377 | 2003-08-01 | Applicant | |
| TW421658 | 2001-02-01 | Applicant | |
| WO91/12823 | 1991-05-01 | Applicant | |
| WO92/21327 | 1992-12-01 | Applicant | |
| WO93/00063 | 1993-01-01 | Applicant | |
| WO93/19702 | 1993-10-01 | Applicant | |
| WO94/10936 | 1994-05-01 | Applicant | |
| WO95/03036 | 1995-02-01 | Applicant | |
| WO95/22318 | 1995-08-01 | Applicant | |
| WO95/33553 | 1995-12-01 | Applicant | |
| WO96/37165 | 1996-11-01 | Applicant | |
| WO96/39464 | 1996-12-01 | Applicant | |
| WO98/04616 | 1998-02-01 | Applicant | |
| WO98/10798 | 1998-03-01 | Applicant | |
| WO98/26737 | 1998-06-01 | Applicant | |
| WO98/47532 | 1998-10-01 | Applicant | |
| WO99/00187 | 1999-01-01 | Applicant | |
| WO99/43380 | 1999-02-01 | Applicant | |
| WO99/12577 | 1999-03-01 | Applicant | |
| WO99/43380 | 1999-09-01 | Applicant | |
| WO99/51278 | 1999-10-01 | Applicant | |
| WO99/57176 | 1999-11-01 | Applicant | |
| WO/23054 | 2000-04-01 | Applicant | |
| WO/032112 | 2000-06-01 | Applicant | |
| WO/40259 | 2000-07-01 | Applicant | |
| WO/71196 | 2000-11-01 | Applicant | |
| WO/74633(A2) | 2000-12-01 | Applicant | |
| WO1/12359 | 2001-02-01 | Applicant | |
| WO1/66016 | 2001-09-01 | Applicant | |
| WO1/70291(A2) | 2001-09-01 | Applicant | |
| WO1/72281 | 2001-10-01 | Applicant | |
| WO1/76845 | 2001-10-01 | Applicant | |
| WO1/93920 | 2001-12-01 | Applicant | |
| WO2/11696(A2) | 2002-02-01 | Applicant | |
| WO2/34298 | 2002-05-01 | Applicant | |
| WO2/34299 | 2002-05-01 | Applicant | |
| WO2/34300 | 2002-05-01 | Applicant | |
| WO2/43580(A2) | 2002-06-01 | Applicant | |
| WO3/016364 | 2003-02-01 | Applicant | |
| WO3/051451 | 2003-06-01 | Applicant | |
| WO3/082359 | 2003-09-01 | Applicant | |
| WO2004/019999 | 2004-03-01 | Applicant | |
| WO4/073688 | 2004-09-01 | Applicant | |
| WO2004/075989 | 2004-09-01 | Applicant |
Non-Patent Literature (224)
- Chuang et al., “Experimental Canine Hepatic Artery Embolization with Polyvinyl Alcohol Foam Particles,” Departments of Diagnostic Radiology and Veterinary Medicine, The University of Texas, M.D. Anderson Hospital and Tumor Institute at Houston, Houston, Texas, pp. 21-25.Applicant
- Kerber, “Flow-Controlled Therapeutic Embolization: A Physiologic and Safe Technique,” AJR, Mar., 1980, vol. 134, pp. 557-561.Applicant
- Kerber et al., “Polyvinyl Alcohol Foam: Prepackaged Emboli for Therapeutic Embolization,” American Journal Roentgenol, Jun. 1978, vol. 130, pp. 1193-1194.Applicant
- Latchaw et al., “Polyvinyl Foam Embolization of Vascular and Neoplastic Lesions of the Head, Neck, and Spine,” Radiology, Jun. 1979, vol. 131, pp. 669-679.Applicant
- Tadavarthy et al., “Polyvinyl Alcohol (Ivalon) as an Embolizing Agent,” The American Journal of Roentgenology Radium Therapy and Nuclear Medicine, Nov., 1975, vol. 125, No. 3, pp. 609-616.Applicant
- Tadavarthy et al., “Polyvinyl Alcohol (Ivalon) as an Embolizing Agent,” Seminars in Interventional Radiology, vol. 1, No. 2, Department of Radiology, University of Minnesota Hospitals, Minneapolis, Minnesota, Jun. 1984, pp. 101-109.Applicant
- Yusi et al., “submuscosal Injection of Polyvinyl Alcohol in Artificially Created Vesico-Ureteral Reflux: A Preliminary Report,” Asian J. Surg. 18(2): 122-127 (Apr. 1995).Applicant
- Beaujeux, R. et al., “Trisacryl Gelatin Microspheres for Therapeutic Embolization, II: Preliminary Clinical Evaluation in Tumors and Arteriovenous Malformations,” AJNR Am. J. Neuroradiol. 17:541-548, Mar. 1996.Applicant
- Stridbeck, H. et al., “Collateral Circulation Following Repeated Distal Embolization of the Hepatic Artery in Pigs,” Invest Radiol 1984;19:179-183.Applicant
- Wright, K.C. et al., “Partial Splenic Embolization Using Polyvinyl Alcohol Foam, Dextran, Polystyrene, or Silicone,” Radiology 142:351-354, Feb. 1982.Applicant
- “Pulmonary artery pseudoaneuyrsm/aneurysm” Available Web Site: http://www.mamc.amedd.army.mil/williams/chest/vascular/paaneurysm/paaneyrysm.htm.Applicant
- Bachtsi, A.R. et al., “An Experimental Investigation of Enzyme Release from Poly(vinyl alcohol) crosslinked Microspheres”, J. Microencapsulation, vol. 12, No. 1, pp. 23-35; 1995.Applicant
- Barr, J.D., et al.,“polyvinyl Alcohol Foam Particles Sizes and Concentrations Injectable through Microcatheters”, JVIR, vol. 9, No. 1, pp. 113-118; 1998.Applicant
- Barttinelli, L. et al., “New Class of Poly(vinyl alcohol) Polymrs as Column- Chromatography Stationary Phases for Candida Rugosa Lipase Isoforms Separation.”, J. Chromatogr A, vol. 753, No. 1, pp. 47-55; 1996. Abstract. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?.Applicant
- Berenstein, A. et al., “Catheter and Material Selection for Transarterial Embolization: Technical Considerations. II. Materials.”, Radiology, vol. 132, No. 3, pp. 631-639; 1979.Applicant
- Berenstein, A. et al., “Microembolization Techniques of Vascular Occlusion: Radiologic, Patohologic, and Clinical Correlation”, AJNR Am I Neuroradiol, vol. 2, No. 3, pp. 261-267; 1981. Abstract, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?.Applicant
- Bruix, J. et al., “Transarterial Embolization Versus Symptomatic Treatment in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized, Controlled Trial in a Single Institution”, Hepatology, Jun. 1998, vol. 27, No. 6, pp. 1578-1583 Available Web Site: http://www.hepatitis-central.com/hcv/hcc/embolization/references.html.Applicant
- Buhle, Jr. EL, “Re: Re: Hepatic Arterial Embolization”, UCLA Medicine Online Available Web Site: http://www.meds.com/archive/mol-cancer/1996/msg00128.html.Applicant
- Burczak, et al., “Long-term in vivo performance and biocompatibility of poly (vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas”, Biomaterials, vol. 17, No. 24, pp. 2351-2356, 1996, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=89824 . . . , pp. 1, 2002.Applicant
- Burczak, et al., “Polymeric materials for biomedical purposes obtained by radiation methods. V. hybrid artificial pancreas”, Polim Med, vol. 24, No. 1-2, pp. 45-55, 1994, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=7915 . . . , pp. 1, 2002.Applicant
- Choe, et al., “An experimental study of embolic effect according to infusion rate and concentration of suspension in transarterial particulate embolization”, Invest Radiol, vol. 32, No. 5, pp. 260-270, 1997, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=9140745&dopt+Abs . . . , pp. 1, 2002.Applicant
- Clarian Health Methodist—Indiana Lions Gamma Knife Center, “Arteriovenous Malformation” Available Web Site: http://www.clarian.com/tyhealth/gammaknife/cond—arter.asp.Applicant
- Colombo M, “Treatment of Hepatocellular Carcinoma”, University of Milan, Inst Internal Med, Irccs Maggiore Res Unit Liver, Canc, Firc, Via Pace 9 1-20122 Milan, Italy Source: Journal of Viral Hepatitis, 1997;4:125-130 Available Web Site: http://home.texoma.net/˜moreland/stats/hcc-9.html.Applicant
- Derdeyn, et al., “Collagen-coated acrylic microspheres for embolotherapy: in vivo and in vitro characteristics”, American Journal of Neuroradiology, vol. 18, No. 4, pp. 647-653, 1997, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=9127025&dopt=Abs . . . , pp. 1, 2002.Applicant
- Derdeyn, et al., “Polyvinyl alcohol particle size and suspension characteristics”, American Journal of Neuroradiology, vol. 16, pp. 1335-1343, 1995.Applicant
- DiLuccio et al., “Sustained-Release Oral Delivery of Theophylline by Use of Polyvinyl Alcohol and Polyvinyl Alcohol-Methyl Acrylate Polymers”, Journal of Pharmaceutical Sciences, Jan. 1994, vol. 83, No. 1, pp. 104-106.Applicant
- Gander, et al., “Effect of polymeric network structure on drug release from cross-linked poly(vinyl alcohol) micromatrices”, Pharm Res, vol. 6, No. 7, pp. 578-584, 1989, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=25080 . . . , pp. 1, 2002.Applicant
- Germano, et al., “Histopathological follow-up study of 66 cerebral arteriovenous malformations after therapeutic embolization with polyvinyl alcohol”, J Neurosurg, vol. 76, No. 4, pp. 607-614, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=15452 . . . , pp. 1, 2002.Applicant
- Geschwind et al., “Chemoembolization of Liver Tumor in a Rabbit Model: Assessment of Tumor Cell Death with Diffusion-Weighted MR Imaging and Histologic Analysis”, Journal of Vascular and Interventional Radiology, Dec. 2000, vol. 11, No. 10, pp. 1244-1255.Applicant
- Gohel, et al., “Formulation design and optimization of modified-release microspheres of diclofenac sodium”, Drug Dev Ind Pharm, vol. 25, No. 2, pp. 247-251, 1999, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=10065360&dop=A . . . , pp. 1, 2002.Applicant
- Goodwin, et al., “Overview of embolic agents and their indications”, Eleventh Annual International Symposium on Endovascular Therapy, pp. 303-306, 1999.Applicant
- Goodwin, et al., “Preliminary experience with uterine artery embolization for uterine fibroids”, Journal of Vascular and Interventional Radiology, vol. 8, No. 4, pp. 517-526, 1997.Applicant
- Grandfils, et al., “Preparation of poly (D,L) lactide microspheres by emulsion solvent evaporation, and their clinical implications as a convenient embolic material”, J Biomed Mater Res, vol. 26, No. 4, pp. 467-479, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=1601900&dopt=Abs . . . , pp. 1, 2002.Applicant
- Hamada, et al., “Embolization with cellulose porous beads, II: Clinical Trial”, abs: http://www.ajnr.org/content/abstract/17/10/1901?ijkey=R.a2vRMietIXw, pp. 1-2, 2002.Applicant
- Horak, et al., “Hydrogels in endovascular embolization. I. Spherical particles of poly (2-hydroxyethyl methacrylate) and their medico-biological properties”, Institute of Surgery, Academy of Medical Sciences of USSR, Mar. 13, 1985 (5 pages).Applicant
- Horak, et al., “Hydrogels in endovascular embolization. II. Clinical use of spherical particles”, Biomaterials, vol. 7 (1986) (4 pages).Applicant
- Huang, et al., “Percutaneous endovascular embolization of intracerebral arteriovenous malformations. Experience in 72 cases”, Chin Med J, vol. 108, No. 6, pp. 413-419, 1995, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=75552 . . . , pp. 1, 2002.Applicant
- International Search Report for International Application No. PCT/US01/06981 (2 pages).Applicant
- Jack, et al., “Radiolabeled polyvinyl alcohol particles: a potential agent to monitor embolization procedures”, Int J Rad Appl Instrum B, vol. 13, No. 3, pp. 235-243, 1986, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=37712, pp. 1, 2002.Applicant
- Joy C, et al., 1991, “Use of Preoperative Embolization in the Treatment of Vascular Metastatic Lesions of the Spine” Available Web Site: http://www.aaos.org/wordhtml/anmeet91/scipro/ppr472.htm.Applicant
- Kai, et al., “The utility of the microcrystalline cellulose sphere as a particulate embolic agent: an experimental study”, American Journal of Radiology, vol. 21, No. 6, pp. 1160-1163, 2000, or http://www.ajnr.org/cgi/content/full/21/6/1160, pp. 1-7, 2002.Applicant
- Kan, et al., “In vivo microscopy of the liver after injection of lipiodol into the hepatic artery and portal vein in the rat”, Acta Radiologica, vol. 30, pp. 419-425, 1989.Applicant
- Kim, et al., “Composite poly(vinyl alcohol) beads for controlled drug delivery”, Pharm Res, vol. 9. No. 1, pp. 10-16, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=1589392&dopt=Abs . . . , pp. 1, 2002.Applicant
- Kurata, et al., “Preoperative embolization for meningiomas using PVA particles”, No Shinkei Geka, vol. 20, No. 4, pp. 367-373, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=1570057&dopt=Abs . . . , pp. 1, 2002.Applicant
- Kurosaki et al., “Evaluation of PVA-Gel Spheres as GI-Transit Time Controlling Oral Drug Delivery System”, Proceedings of the 19th International Symposium on Controlled Release of Bioactive Materials, Jul. 26-31, 1992, Orlando, Florida, pp. 273-274.Applicant
- Kusano, et al., “Low-dose particulate polyvinylalcohol embolization in massive small artery intenstinal hemorrahage. Experimental and clinical results”, Invest Radiol, vol. 22, No. 5, pp. 388-392, 1987, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=34963 . . . , pp. 1, 2002.Applicant
- Labarre et al., “Complement activation by substituted polyacrylamide hydrogels for embolisation and implantation”, Biomaterials, vol. 23, pp. 2319-2327, 2002.Applicant
- Lammer, et al., “Transcatheteral embolization with polyvinyl alcohol—technic and experimental studies”, Rontgenblatter, vol. 36, No. 1, pp. 10-14, 1983, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=6823530&dop=Abs . . . , pp. 1, 2002.Applicant
- Leung et al., “Determinants of Postembolization Syndrome after Hepatic Chemoembolization”, Journal of Vascular and Interventional Radiology, Mar. 2001, vol. 12, No. 3, pp. 320-326.Applicant
- Markoff, et al., “Uterine arteriovenous malformation successfully embolized with a liquid polymer, isobutyl 2-cyanoacrylate”, pp. 659-660, 1999.Applicant
- Markus, H.S., “Experimental Aspects of High-Intensity Transient Signals in the Detection of Emboli,” J Clin Ultrascound 23:81-87 (1995).Applicant
- Matsumaru, et al., “Embolic materials for endovascular treatment of cerebral lesions”, J Biomater Sci Polym Ed, vol. 8, No. 7, pp. 555-569, 1997, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=91953 . . . , pp. 1, 2002.Applicant
- Mid-America Interventional Radiological Society, “New Treatment for Uterine Fibroids Avoids Surgery” Available Web Site: http://www.mirs.org/fibroids.htm.Applicant
- Nakabayashi, et al., “Evaluation of particulate embolic materials with MR imaging, scanning electron microscopy, and phase-contrast microscopy”, American Journal of Neuroradiology, vol. 18, No. 3, pp. 485-491, 1997, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=90904 . . . , pp. 1-2, 2002.Applicant
- Nakstad, et al., “Embolization of intracranial arteriovenous malformations and fistulas with polyvinyl alcohol particles nad platinum fibre coils”, Neuroradiology, vol. 34, No. 4, pp. 348-351, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=15284 . . . , pp. 1, 2002.Applicant
- Nash, et al., “Modifications of polystyrenic matrices for the purification of proteins. II. Effect of the degree of glutaraldehyde-poly(vinyl alcohol) crosslinking on various dye ligand chromatography systems”, J Chromatogr A, vol. 776, No. 1, pp. 55-63, 1997, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=92860 . . . , pp. 1, 2002.Applicant
- Nikishin LF et al., 1999, “Interventional radiology in diffuse toxic goiter”, European Congress of Radiology—ECR 1999 Available Web Site: http://www.ecr.org/conferences/ecr1999/sciprg/abs/p090041.htm.Applicant
- Ophir, et al., “Ultrasonic backscatter from contrast producing collagen microspheres”, Ultrasonic Imaging, vol. 2, pp. 67-77, 1980.Applicant
- Oregon Health Sciences University, “Fibroid Embolization” Available Web Site: http://www.uhmc.edu/dotter-fibroid.Applicant
- Parker, et al., “A particulate contrast agent with potential for ultrasound imaging of liver”, Ultrasound in Medicine and Biology, vol. 13, No. 9, pp. 555-566, 1987.Applicant
- Pesant A.C. et al., 1997, “Dural fistulas involving the cavernous sinus: Treatment by embolization—7 cases”, European Congress of Radiology—ECR 1997 Available Web Site: http://www.ecr.org/conferences/ecr1997/sciprg/abs/9703088p.htm.Applicant
- Physicians' Desk Reference Family Guide to Women's Health, “Chapter 7—Common Disorders of the Reproductive System” Available Web Site: http://www.healthsquare.com/pdrfg/wh/chapters/wh1ch01.htm.Applicant
- Pritchard, et al., “Poly(Vinyl Alcohol): Basic Properties and Uses”, London, England: Gordon and Breach Science Publishers,Gordon and Breach, Science Publishers, Ltd. 1970.Applicant
- Pryor J and Berenstein A., “Epistaxis (Nose-bleeds)” Available Web Site: http://www.wehealny.org/inn/Radiology/nosebleeds.html.Applicant
- Purdy, et al., “Arteriovenous malformations of the brain: choosing embolic materials to enhance safety and ease of excision”, J Neurosurg, vol. 77, No. 2, pp. 217-222, 1992, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=16250 . . . , pp. 1-2, 2002.Applicant
- Quisling, et al., “Histopathology analysis of intraarterial polyvinyl alcohol microemboli in rat cerebral cortex”, American Journal of Neuroradiology, vol. 5, pp. 101-104, 1984.Applicant
- Rajan et al., “Sarcomas Metastatic to the Liver: Response and Survial after Cisplatin, Doxorubicin, Mitomycin-C, Ethiodol, and Polyvinyl Alcohol Chemoembolization”, Journal of Vascular and Interventional Radiology, Feb. 2001, vol. 12, No. 2, pp. 187-193.Applicant
- Ramos, et al., “Tumor vascular signals in renal masses: detection with Doppler US”, Radiology, vol. 168, No. 3, pp. 633-637, 1988.Applicant
- Schwarz, K.Q., “The Acoustic Filter: An Ultrasonic Blood Filter for the Heart-Lung Machine,” Journal of Thoracic and Cardiovascular Surgery 104(6):1647-1653 (1992).Applicant
- Shafik, A., “Intraesophageal Polytef injection for the treatment of reflux esophagitis”, Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt, pp. 1-2, Received: Jun. 22, 1994; Accepted: Oct. 15, 1994 http://www.ahmedshafik.org/Group-D/d016.htm.Applicant
- Spickler, et al., “The MR appearance of endovascular embolic agents in vitro with clinical correlation”, Comput Med Imaging Graph, vol. 14, No. 6, pp. 415-423, 1990, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=21487 . . . , pp. 1, 2002.Applicant
- Spies JB, “Georgetown University Medical Center. Uterine Fibroid Embolization (UFE). An alternative to surgery for patients with uterine fibroids. Literature Review.” Available Web Site: http://www.dml.georgetown.edu/fibroids.Applicant
- Strunk, et al., “Treatment of congenital coronary arteriovenous malformations with microparticle embolization”, Cathet Cardiovasc Diagn, vol. 22, No. 2, pp. 133-136, 1991, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=2009563&dop=Abs . . . , pp. 1, 2002.Applicant
- Swanson DA et al., 1980, “The role of embolization and nephrectomy in the treatment of metastatic renal carcinoma”, Urologic Clinics of North America 7(3):719-730, 1980. University of Pennsylvania Cancer Center—Oncolink. Available Web Site: http://www.oncolink.upenn.edu/pdg—html/cites/00/00585.html.Applicant
- Tabata et al., “Tumor accumulation of poly(vinyl alcohol) of different sizes after intravenous injection”, Journal of Controlled Release, Jan. 2, 1998, vol. 50, Nos. 1-3, pp. 123-133.Applicant
- Tao, et al., “Study of microspheres for embolization of the hepatic artery”, Yao Xue Xue Bao, vol. 23, No. 1, pp. 55-60, 1988, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=3400477&dop=A, pp. 1, 2002.Applicant
- Tao, et al., “Study on embolization of hepatitic artery using microspheres”, Acta Pharmaceutica Sinica vol. 23, No. 1, pp. 55-60; 1988. Translation.Applicant
- Terada, et al., “Preoperative embolization of meningiomas fed by ophthalmic branch arteries”, Surg Neurol, vol. 45, No. 2, pp. 161-166, 1996, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=86070 . . . , pp. 1, 2002.Applicant
- Thanoo, et al., “Controlled release of oral drugs from cross-linked polyvinyl alcohol microspheres”, J Pharm Pharmacol, vol. 45, No. 1, pp. 16-20, 1993, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=8094438&dop=Abs . . . , pp. 1, 2002.Applicant
- Thanoo, et al., “Tantalum loaded silicone micropsheres as particulate emboli”, J Microencapsul, vol. 8, No. 1, pp. 95-101, 1991, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=1880697&dop=Abs . . . , pp. 1, 2002.Applicant
- The Fibroid Embolization Center of the New York United Hospital Medical Center, “Fibroid Facts” Available Web Site: http://www.uhmc.com/fibro2.htm.Applicant
- The Vanderbilt-Ingram Cancer Center, “Kidney Cancer.” Available Web Site: http://www.mc.Vanderbilt.Edu/cancer/cancerinfo/kidney.html.Applicant
- Tikkakoski, et al., “Preoperative embolization in the management of neck paragangliomas”, Laryngoscope, vol. 107, pp. 821-826, 1997.Applicant
- Touho, et al., “Intravascular treatment of spinal arteriovenous malformations using a microcatheter—with special reference to serial xylocaine tests and intravascular pressure monitoring”, Surgical Neurology, vol. 42, No. 2, pp. 148-156. 1994, abs: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=PubMed&list—uids=80912 . . . , pp. 1, 2002.Applicant
- UCLA Medical Group, “Uterine Embolization—Introduction—Statistics—Preservation of Fertility.” Available Web Site: http://www.fibroids.org.Applicant
- UCLA Radiological Sciences, “A summary of terms appearing in this text.” Available Web Site: http://www.radsci.ucla.edu:8000/aneurysm/terms.html.Applicant
- University Medical Center SUNY Stony Brook, Department of Urology, “Variococele and its treatment.” Available Web Site: http://www.hsc.sunysb.edu/urology/male—inf . . . variocoele—and—its—treatment.html.Applicant
- Vivas S et al., “Arterioportal fistula and hemobilia in a patient with hepatic transplant”, Gastroenterol Hepatol, Feb. 1998,;21(2):88-9 Available Web Site: http://www.doyma.es/copiani/revistas/gastro/abstr/abs—p080.html.Applicant
- Vogel F, “Nonsurgical Management of Uterine Fibroids” Available Web Site: http://www.holyname.org/brochure/fibroids.html.Applicant
- Wakhloo, et al., “Extended preoperative polyvinyl alcohol microembolization of intracranial meningiomas: Assessment of two embolization techniques”, American Journal of Neuroradiology, vol. 14, pp. 571-582, 1993.Applicant
- Walker WJ, “Non Surgical Treatment of Fibroids in the UK by Uterine Artery Embolisation—An Alternative to Hysterectomy, Myomectomy and Myolysis” Available Web Site: http://www.fibroids.co.uk/thepaper.html.Applicant
- Walsh RM et al., 1998, “Role of Angiography and Embolization for Acute Massive Upper Gastronintestinal Hemorrhage.” Department of General Surgery and Radiology, Cleveland Clinic Foundation, Cleveland, Ohio. Available Web Site: http://www.ssat.com/98ddw/abstscorrt-47.html.Applicant
- Wikholm G et al., 1996, “Embolization of Cerebral Arteriovenous Malformations: Part I—Technique, Morphology, and Complications”, Departments of Neurology (CL) and Interventional Radiology (GW, PS), Sahlgrenska University Hospital, Goteborg, Sweden. Neurosurgery. Sep. 1996,;39(3):448-57; discussion 457-9. Available Web Site: http://www.wwilkins.com/neurosurgery/0148-396X9-96inter.html.Applicant
- Worthington-Kirsch RL, 1999, “Interventionalists offer management option for uterine fibroids.” Diagnostic Imaging, pp. 47-49. Available Web Site: http://www.dimag.com/references/9903wortrefs.html.Applicant
- Worthington-Kirsch, et al., “Uterine arterial embolization for the management of leiomyomas: Quality-of-life assessment and clinical response”, Radiology, vol. 208, No. 3, 625-629, 1998.Applicant
- Yamada, et al., “Extended intraarterial cisplatin infusion for treatment of gynecological cancer after alteration of intrapelvic blood flow and implantation of a vascular access device”, Cardiovasc Intervent Radiol (1996) 19:139-145.Applicant
- Abbara, S. et al., “Transcervical Expulsion of a Fibroid as a Result of Uterine Artery Embolization for Leiomyomata”, JVIR, vol. 10, No. 4, pp. 409-411; 1999.Applicant
- Abrahams, J.M. et al., “Topic Review: Surface Modifications Enhancing Biological Activity of Guglielmi Detachable Coils in Treating Intracranial Aneurysms”, Surg. Neurol. 54:34-41, 2000.Applicant
- Abrahams, J.M. et al., “Delivery of Human Vascular Endothelial Growth Factor with Platinum Coils Enhances Wall Thickening and Coil Impregnation in a Rat Aneurysm Model”, AJNR Am. J. Neuroradiol. 22:1410-1417, Aug. 2001.Applicant
- Ahuja, A.A., “Platinum Coil Coatings to Increase Thrombogenicity: A Preliminary Study in Rabbits”, AJNR Am. J. Neuroradiol. 14:794-798; Jul./Aug. 1993.Applicant
- Antibody Labeling http://www.altcorp.com/AffinityLabeling/ablaeling.htm, pp. 1-6, May 20, 2003.Applicant
- Berkowitz, R.P. et al., “Vaginal Expulsion of Submucosal Fibroids After Uterine Artery Embolization”, Journal of Reproductive Medicine, vol. 44, No. 4, pp. 373-376; Apr. 1999 http://www.reproductivemedicine.com.Applicant
- Bradley, E.A. et al., “Transcatheter Uterine Artery Embolisation to Treat Large Uterine Fibroids”, British Journal of Obstetrics and Gynaecology, vol. 105, pp. 235-240; Feb. 1998.Applicant
- Brockmann, J. et al., “Radiolabeling of p-Bz-DOTA-CD-11c antibody with 88Y: Conjugation, Labeling, Biodistribution studies”, 2 pages, 2000 http://www.kernchemie.uni-mainz.de/downloads/jb2000/b14—brockmann.pdf.Applicant
- Carroll, B.A. et al., “Microbubbles as Ultrasonic Contrast Agents”, Investigative Radiology, vol. 14, No. 3, Supplement to May-Jun. 1979.Applicant
- Carroll, B.A. et al., “Gelatin Encapsulated Nitrogen Microbubbles as Ultrasonic Contrast Agents”, Journal of Clinical and Laboratory Research, vol. 15, No. 1; Feb. 1980.Applicant
- Carstensen, E.L. et al., “Determination of the Acoustic Properties of Blood and its Components”, Journal of Acoustical Society of America, vol. 25, No. 2; Mar. 1953.Applicant
- Cirkel, U. et al., “Experience with Leuprorelin Acetate Depot in the Treatment of Fibroids: A German Multicentre Study”, Clinical Therapeutics, vol. 14, Suppl. A, 1992.Applicant
- Deasy, P. B., “Microencapsulation and Related Drug Processes”, New York, NY, Marcel Dekker, Inc., 345 pages, 1984 (Table of Contents only).Applicant
- DeGast, A.N. et al., “Transforming Growth Factor β-coated Platinum Coils for Endovascular Treatment of Aneurysms: An Animal Study”, Neurosurgery, vol. 49, No. 3, pp. 690-696, Sep. 2001.Applicant
- Feldman, L. et al., “Transcatheter Vessel Occlusion: Angiographic Results Versus Clinical Success”, Radiology, vol. 147, pp. 1-5, Apr. 1983.Applicant
- Ferrofluids, Physical Properties and Applications Ferrofluidics Corp., Nashua, NH, 5 pages, 1986.Applicant
- FeRx Incorporated, FERX Profile http://www.biotechshares.com/FERX.htm, 4 pages [retrieved from the internet Jun. 26, 2003].Applicant
- Fritzsch, T. et al., “SH U 508, A Transpulmonary Echocontrast Agent”, Investigative Radiology, vol. 25, Supplement 1, pp. S160-S161, Sep. 1990.Applicant
- Fujimoto, S. et al., “Biodegradable Mitomycin C Microspheres Given Intra-Arterially for Inoperable Hepatic Cancer”, Cancer, vol. 56, pp. 2404-2410, 1985.Applicant
- Gilbert, W.M. et al., “Angiographic Embolization in the Management of Hemorrhagic Complications of Pregnancy”, American Journal of Obstetrics and Gynecology, vol. 166, No. 2, pp. 493-497, Feb. 1992.Applicant
- Goldberg, B.B., “Ultrasonic Cholangiography”, Radiology, vol. 118, pp. 401-404, Feb. 1976.Applicant
- Gramiak, R. et al., “Ultrasound Cardiography: Contrast Studies in Anatomy and Function”, Radiology, vol. 92, No. 5, pp. 939-948, Apr. 1969.Applicant
- Greenwood, L.H. et al., “Obstetric and Nonmalignant Gynecologic Bleeding: Treatment with Angiographic Embolization”, Radiology, vol. 164, No. 1, pp. 155-159, Jul. 1987.Applicant
- Jones, S.K. et al., “Experimental Examination of a Targeted Hyperthermia System Using Inductively Heated Ferromagnetic Microspheres in Rabbit Kidney”, Phys. Med. Biol., vol. 46, No. 2, pp. 385-398, Feb. 2001 www.iop.org/Journals/pb.Applicant
- Kallmes, D.F. et al., “In Vitro Proliferation and Adhesion of Basic Fibroblast Growth Factor-producing Fibroblasts on Platinum Coils”, Radiology, vol. 206, No. 1, pp. 237-243, Jan. 1998.Applicant
- Kerber, C., “Balloon Catheter with a Calibrated Leak”, Radiology, vol. 120, pp. 547-550, Sep. 1976.Applicant
- Kochan, J.P. et al., “Interventional Neuroradiology: Current Practices and Techniques at Temple University Hospital” http://www.temple.edu/radiology/stroke.html, 5 pages.Applicant
- Kuhn, R. et al., “Embolic Occlusion of the Blood Supply to Uterine Myomas: Report of 2 Cases”, Aust. NZ. J. Obstet. Gynaecol., vol. 39, No. 1, pp. 120-122, Feb. 1999.Applicant
- Kurbatova, G.T. et al., “Magnetically-guided Anesthetics Based on Highly Dispersed Iron Powders Coated by Polyacrylamide”, Biofizika, vol. 47, No. 2, pp. 331-337, Mar.-Apr. 2002 http://intapp.medscape.com/px/medlineapp.Applicant
- Lendlein, A. et al., “Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications”, Science, vol. 296, pp. 1673-1676, May 31, 2002.Applicant
- Leventon, William, “Hemocompatible Coatings for Blood-Contacting Devices”, Medical Device & Diagnostic Industry: Coating Technologies—New Methods to Ensure Blood Compatibility, vol. 25, No. 8, pp. 62-67, Aug. 2003.Applicant
- Lowery, C.L. et al., “Screening Tests for Intrauterine Growth Retardation: A Comparison of Umbilical Artery Doppler to Real-Time Ultrasound”, Echocardiography, vol. 7, No. 2, pp. 159-164, Mar. 1990.Applicant
- Marich, K.W. et al., “Real-Time Imaging with a New Ultrasonic Camera: Part I, In Vitro Experimental Studies on Transmission Imaging of Biological Structures”, Journal of Clinical Ultrasound, vol. 3, No. 1, pp. 5-16, Mar. 1975.Applicant
- Markus, H.S., “Experimental Aspects of High-Intensity Transient Signals in the Detection of Emboli,” J Clin Ultrasound 23:81-87 (1995).Applicant
- Marx, W. F. et al., “Endovascular Treatment of Experimental Aneurysms by Use of Biologically Modified Embolic Devices: Coil-mediated Intraaneurysmal Delivery of Fibroblast Tissue Allografts”, AJNR. Am. J. Neuroradiol., vol. 22, pp. 323-333, Feb. 2001.Applicant
- Mather, P.T., Research Group Homepage, Basic Goals and Methods http://www.ims.uconn.edu/-mather, 4 pages.Applicant
- Matsumoto, H. et al., “Basic Fibroblast Growth Factor Released from a Platinum Coil with a Polyvinyl Alcohol Core Enhances Cellular Proliferation and Vascular Wall Thickness: An In Vitro and In Vivo Study”, Neurosurgery, vol. 53, No. 2, pp. 402-408, Aug. 2003.Applicant
- Matsumoto, Y. et al., “Room-Temperature Ferromagnetism in Transparent Transition Metal-Doped Titanium Dioxide”, Science, vol. 291, pp. 854-856, Feb. 2, 2001 www.sciencemag.org.Applicant
- McIvor, J. et al., “Pregnancy After Uterine Artery Embolization to Control Haemorrhage from Gestational Trophoblastic Tumour”, British Journal of Radiology, vol. 69, No. 823, pp. 624-629, Jul. 1996.Applicant
- MerocelXL Sponge with Hytrol http://www.xomed.com/newproducts/mercocelxl/merocelxl—earwick.asp, 3 pages, 2001.Applicant
- Moroz, P. et al., “Arterial Embolization Hyperthermia in Porcine Renal Tissue”, Journal of Surgical Research, vol. 105, No. 2, pp. 209-214, Jun. 15, 2002.Applicant
- Moroz, P. et al., “Hepatic Clearance of Arterially Infused Ferromagnetic Particles”, Int. J. Hyperthermia, vol. 19, No. 1, pp. 23-24, Feb. 2003 http://www.tandf.co.uk/journals.Applicant
- Orsini, L. F. et al., “Pelvic Organs in Premenarcheal Girls: Real-Time Ultrasonography”, Radiology, vol. 153, No. 1, pp. 113-116, Oct. 1984.Applicant
- Phillips, D. R. et al., “Experience with Laparoscopic Leiomyoma Coagulation and Concomitant Operative Hysteroscopy”, J. Am. Assoc. Gynecol. Laparosc, vol. 4, No. 4, pp. 425-533, Aug. 1997.Applicant
- Poppe, W. et al., “Pregnancy after Transcatheter Embolization of a Uterine Arteriovenous Malformation”, Am. J. Obstet. Gynecol., vol. 156, No. 5, pp. 1179-1180, May 1987.Applicant
- Ravina, J.H. et al., “Advantage of Pre-Operative Embolization of Fibroids: About a Multicentric Set of 31 Cases”, Contracept. Fertil. Sex., vol. 23, No. 1, pp. 45-49, Jan. 1995 (abstract).Applicant
- Ravina, J.H. et al., “Arterial Embolisation to Treat Uterine Myomata”, Lancet, vol. 346, pp. 671-674, Sep. 9, 1995.Applicant
- Ravina, J.H. et al., “Interest of Particulate Arterial Embolization in the Treatment of Some Uterine Myoma”, Bull. Acad. Natle. Med., vol. 181, No. 2, pp. 233-246, Feb. 4, 1997 (Summary).Applicant
- Schlief, R. et al., “Enhanced Color Doppler Echocardiography of the Left Heart After Intravenous Injection of a New Saccharide Based Agent in Humans”, Circulation, vol. 82, No. 2, p. 28, Oct. 1990 (Abstract).Applicant
- Schlief, R. et al., “Successful Opacification of the Left Heart Chamber on Echocardiographic Examination after Intravenous Injection of a New Saccharide Based Contrast Agent”, Echocardiography, vol. 7, No. 1, pp. 61-64, Jan. 1990.Applicant
- Shape Shifters http://www.sciam.com/tehbiz/0501scicit6.html, 3 pages, 2001.Applicant
- Shung, K.K. et al., “Scattering of Ultrasound by Blood”, IEEE Transactions on Biomedical Engineering, vol. BME-23, No. 6, pp. 460-467, Nov. 1976.Applicant
- Sigelmann, R.A. et al., “Analysis and Measurement of Ultrasound Backscattering from an Ensemble of Scatters Excited by Sine-Wave Bursts”, Journal of Acoustical Society of America, vol. 53, No. 4, pp. 1351-1355, Apr. 1973.Applicant
- SIR-Spheres (Yttrium-90 Microspheres), pp. 1-12.Applicant
- SIR-Spheres, Radioactive Implant (Yttrium-90 Microspheres), Sirex Medical, Inc., San Diego, CA, Nov. 6, 2000, pp. 1-15.Applicant
- Sirtex Medical Limited—Product Description http://www.sirtex.com/?p=72 [retrieved from the internet on May 27, 2003].Applicant
- Sirtex Medical Limited—Targeted Radiotherapy with SIR-Spheres http://www.sirtex.com/?p=57 [retrieved from the internet May 27, 2003].Applicant
- Skotland, T. et al., “In Vitro Stability Analyses as a Model for Metabolism of Ferromagnetic Particles (Clariscan™), a Contrast Agent for Magnetic Resonance Imaging”, J. Pharm. Biomed. Anal., vol. 28, No. 2, pp. 323-329, Apr. 15, 2002.Applicant
- “Smart Sutures Tie Themselves”, Apr. 26, 2002 http://www.sciam.com/article.cfm?articleID=00047706-121F-1CD0-B4A8809EC588.Applicant
- Smith, M.D. et al., “Left Heart Opacification with Peripheral Venous Injection of a New Saccharide Echo Contrast Agent in Dogs”, JACC, vol. 13, No. 7, pp. 1622-1628, Jun. 1989.Applicant
- Stancato-Pasik, A. et al., “Obstetric Embolotherapy: Effect on Menses and Pregnancy”, Radiology, vol. 204, No. 3, pp. 791-793, Sep. 1997.Applicant
- Stein, R. et al., “Targeting Human Cancer Xenografts with Monoclonal Antibodies Labeled Using Radioiodinated, Diethylenetriaminepentaacetic Acid-appended Peptides”, Clinical Cancer Research, vol. 5, No. 10, pp. 3079-3087, Oct. 1999 (Supplement).Applicant
- Tamatani, S. et al., “Histological Interaction of Cultured Endothelial Cells and Endovascular Embolic Materials Coated with Extracellular Matrix”, J. Neurosurg., vol. 86, No. 1, pp. 109-112, Jan. 1997.Applicant
- Thelen, V.M. et al., “Catheter Embolisation of Metastasising Renal Carcinomas Using Butyle-2-cyano-acrylate”, Fortschr. Rontgenstr., vol. 124, No. 3, pp. 232-235, Mar. 1976.Applicant
- Waltman, A.C. et al., “Technique for Left Gastric Artery Catheterization”, Radiology, vol. 109, No. 3, pp. 732-734, Dec. 1973.Applicant
- White, Jr., R.I., “Embolotherapy in Vascular Disease”, AJR, vol. 142, pp. 17-30, Jan. 1984.Applicant
- Widder, K.J. et al., “Selective Targeting of Magnetic Microspheres Containing Adriamycin: Total Remission in Yoshida Sarcoma-Bearing Rats”, Proceedings of the 16th Annual Meeting of American Society of Clinical Oncology, May 26-27, 1980, San Diego, CA, p. 261.Applicant
- Widder, K. et al., “Magnetic Microspheres: Synthesis of a Novel Parenteral Drug Carrier”, Journal of Pharmaceutical Sciences, vol. 68, No. 1, pp. 79-82, Jan. 1979.Applicant
- Worthington-Kirsch, R.L. et al., “Uterine Arterial Embolization for the Management of Leiomyomas: Quality-of-Life Assessment and Clinical Response”, Radiology, vol. 208, No. 3, Sep. 1998.Applicant
- Wu, A.M., “Engineered Antibodies for Breast Cancer Imaging and Therapy” http://www.ucop.edu/srphome/bcrp/progressreport/abstracts/innov/21B-0084.html.Applicant
- Yamada, T. et al., “Extended Intraarterial Cisplatin Infusion for Treatment of Gynecologic Cancer After Altercation of Intrapelvic Blood Flow and Implantation of a Vascular Access Device”, Cardiovasc. Intervent. Radiol., vol. 19, pp. 139-145, 1996.Applicant
- Yamashita, Y. et al., “Transcatheter Arterial Embolization of Obstetric and Gynaecological Bleeding: Efficacy and Clinical Outcome”, British Journal of Radiology, vol. 67, pp. 530-534, Jun. 1994.Applicant
- Ziskin, M.C. et al., “Contrast Agents for Diagnostic Ultrasound”, Investigative Radiology, vol. 7, No. 6, pp. 500-505, Nov.-Dec. 1972.Applicant
- “Injectable Tissue Implant Could Repair Ravages of Surgery”, Clemson University, Biotech Week, Oct. 22, 2003, p. 117.Applicant
- Concentric Medical, Inc.- Product Information (3 pages), 2002.Applicant
- “Improving a Key Weapon Against Cancer”, Research Horizons, Spring/Summer 2001, pp. 11-12.Applicant
- Kim et al., “Hollow Silica Spheres of Controlled Size and Porosity by Sol-Gel Processing,” J. Am. Ceram. Soc., 74(8):1987-1992 (Aug. 1991).Applicant
- Bourke et al., “Protein Drug Release from Photocrosslinked Poly(vinyl alcohol) Hydrogels,” Socieity for Biomaterials 28th Annual Meeting Transactions, p. 144 (2002).Applicant
- Capozza et al., “Endoscopic treatment of vesico-ureteric reflux and urinary incontinence: technical problems in the paediatric patient,” British Journal of Urology, 75(4):538-542 (Apr. 1995).Applicant
- Cruise et al., “In Vitro and In Vivo Characterization of a Hydrogel-Based Aneurysm Embolization System,” Society for Biomaterials 28th Annual Meeting Transactions, p. 203 (2002).Applicant
- Duckwiler et al., “Catheters, embolic agents spark neurointervention,” Diagnostic Imaging, 16(5):66-72 (May 1994).Applicant
- Ersek et al., “Bioplastique: A New Textured Copolymer Microparticle Promises Permanence in Soft-Tissue Augmentation,” Plastic and Reconstructive Surgery, 87(4):693-702 (Apr. 1991).Applicant
- Eskridge, “Interventional Neuroradiology,” Radiology, 172:991-1006 (Nov. 1989).Applicant
- Gramiak et al., “Echocardiography of the Aortic Root,” Investigative Radiology, 3(5):356-366 (Sep.-Oct. 1968).Applicant
- Gupta et al., “Plasma-induced graft polymerization of acrylic acid onto poly(ethylene terephthalate) films: characterization and human smooth muscle cell growth on grafted films,” Biomaterials, 23:863-871 (2002).Applicant
- Halstenberg et al., “Biologically Engineered Protein-graft-Poly(ethylene glycol) Hydrogels: A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair,” Biomacromolecules, 3(4):710-723 (2002).Applicant
- Hirano et al., “Transcutaneous Intrafold Injection For Unilateral Vocal Fold Paralysis: Functional Results,” Ann. Otol. Rhinol Laryngol., 99(8):598-604 (Aug. 1990).Applicant
- Jung et al., “Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide)s facilitate the preparation of small negatively charged biodegradable nanospheres,” Journal of Controlled Release, 67:157-169 (2000).Applicant
- Khankan et al., “Embolic Effects of Superabsorbent Polymer Microspheres in Rabbit Renal Moel: Comparison with Tris-acryl Gelatin Microspheres and Polyvinyl Alcohol,” Radiation Medicine, 22(6):384-390 (2004).Applicant
- Kim et al., “Poly(vinyl alcohol) beads with core-shell structure for drug delivery,” Cosmetic and Pharmaceutical Applications of Polymers, Plenum Press, New York, pp. 209-214 (1991).Applicant
- Kim et al., “Suspension polymerized poly(vinyl alcohol) beads for drug delivery,” Polymeric Materials: Science and Engineering, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 63:64-67 (1990).Applicant
- Krinick et al., “A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light,” J. Biomater. Sci. Polymer Edn, 5(4):303-324 (1994).Applicant
- Laurent, “Materials and biomaterials for interventional radiology,” Biomed. & Pharmacother., 52:76-88 (1998).Applicant
- Lemperle et al., “PMMA Microspheres for Intradermal Implantation: Part I. Animal Research,” Annals of Plastic Surgery, 26(1):56-63 (Jan. 1991).Applicant
- Levy et al., “Transcatheter Uterine Artery Embolization for the Treatment of Symptomatic Uterine Fibroid Tumors,” Journal of Women's Imaging, 2(4):168-175 (2000).Applicant
- Lipman, “Uterine artery embolization for the treatment of symptomatic uterine fibroids: A review,” Applied Radiology, 29(7):15-20 (Jul. 2000).Applicant
- Maruhashi, “Modified Polyvinyl Alcohols I and II,” Polyvinyl Alcohol—Developments, John Wiley & Sons, Chichester, England, pp. 160-161 and pp. 186-191 (1992).Applicant
- Namiki, “Application of Teflon Paste for Urinary Incontinence—Report of 2 Cases,” Uro. Int., 39:280-282 (1984).Applicant
- Orienti et al., “Crosslinked Polyvinylalcohol Hydrogels as Vehicles for Hydrophilic Drugs,” Arch. Pharm. Pharm. Med. Chem., 333:421-424 (2000).Applicant
- Pedley et al., “Hydrogels in Biomedical Applications,” British Polymer Journal, 12:99-110 (Sep. 1980).Applicant
- Pistel et al., “Brush-like branched biodegradable polyesters, part III Protein release from microspheres of poly(vinyl alcohol)-graft-poly(D,L-lactic-co-glycolic acid),” Journal of Controlled Release, 73:7-20 (2001).Applicant
- Politano et al., “Periurethral Teflon Injection for Urinary Incontinence,” The Journal of Urology, 111:180-183 (1974).Applicant
- Progelhof et al., “Table 4.21. Properties of electrical insulating films (101),” Polymer Engineering Principles: Properties, Processes, and Tests for Design, Hanser Publishers, Munich, p. 383 (1993).Applicant
- PVA Plus, AngioDynamics® Inc., “Reliable PVA Foam Formulated for Consistency and Controlled Delivery—Embolization Particles Ordering Information,” www.angiodynamics.com, 2 pages (Aug. 2002).Applicant
- Rhine et al., “Polymers for Sustained Macromolecule Release: Procedures to Fabricate Reproducible Delivery Systems and Control Release Kinetics,” Journal of Pharmaceutical Sciences, 69(3):265-270 (Mar. 1980).Applicant
- Schetky, “Shape-Memory Alloys,” Encyclopedia of Chemical Technology, Third Edition, vol. 20, John Wiley & Sons, New York, pp. 726-736 (1982).Applicant
- Shafik, “Intraesophageal Polytef injection for the treatment of reflux esophagitis,” Surg. Endosc., 10:329-331 (1996).Applicant
- Siskin et al., “Pathologic Evaluation of a Spherical Polyvinyl Alcohol Embolic Agent in a Porcine Renal Model,” J. Vasc. Interv. Radiol., 14:89-98 (2003).Applicant
- Smith et al., “Evaluation of Polydimethylsiloxane as an alternative in the Endoscopic Treatment of Vesicoureteral Reflux,” The Journal of Urology, 152:1221-1224 (Oct. 1994).Applicant
- Soppimath et al., “Controlled release of antihypertensive drug from the interpenetrating network poly(vinyl alcohol)-guar gum hydrogel microspheres,” J. Biomater. Sci. Polymer Edn, 11(1):27-43 (2000).Applicant
- Strasnick et al., “Transcutaneous Teflon® Injection for Unilateral Vocal Cord Paralysis: An Update,” The Laryngoscope, 101:785-787 (Jul. 1991).Applicant
- Tian et al., “Design and synthesis of amphiphilic poly (ethylene glycol) derivatives as micellar drug delivery systems,” Polymer Preprints, 43(2):719-720 (Fall 2002).Applicant
- White, Jr., “Embolotherapy in Vascular Disease,” American Journal of Roentgenology, 142:27-30 (Jan. 1984).Applicant
- Winters et al., “Periurethral injection of collagen in the treatment of intrinsic sphincteric deficiency in the female patient,” The Urologic Clinics of North America, 22(3):673-678 (Aug. 1995).Applicant
- Yoon et al., “Surface Immobilization of Galactose onto Aliphatic Biodegradable Polymers for Hepatocyte Culture,” Biotechnol. Bioeng., 78(1):1-10 (Apr. 5, 2002).Applicant
- Zisch et al., “Covalently conjugated VEGF-fibrin matrices for endothelialization,” Journal of Controlled Release, 72:101-113 (2001).Applicant
- Beaujeux, R. et al, “Trisacryl Gelatin Microspheres for Therapeutic Embolization, II: Preliminary Clinical Evalution in Tumors and Arteriovenous Malformations,” AJNR Am J. Neuroradiol. 17:541-548, Mar. 1996.Applicant
- Stridbeck, H. et al., “Collateral Circulation Following Repeated Distal Embolization of the Hepatic Artery in Pigs,” Invest Radiol 1984;19:179-183.Applicant
- Wright, K.C. et al., “Partial Splenic Embolization Using Polyvinyl Alcohol Foam, Dextran, Polystyrene, or Silicone,” Radiology 142:351-354, Feb. 1982.Applicant
- Yusi et al., “submuscosal Injection of Polyvinyl Alcohol in Artificially Created Vesico-Ureteral Reflux: A Preliminary Report,” Asian J. Surg. 18(2): 122-127 (Apr. 1995).Applicant
- Barton, P. et al., “Embolization of Bone Metastases”, Journal of Vascular and Interventional Radiology, vol. 7, No. 1, Jan.-Feb. 1996, p. 81-88.Applicant
- Jiaqi, Y. et al., “A New Embolic Material: Super Absorbent Polymer (SAP) Microsphere and Its Embolic Effects”, Nippon Acta Radiologica 1996 (56):19-24.Applicant
- Mavligit, G. et al., “Gastrointestinal Leiomyosarcoma Metastatic to the Liver”, Cancer, vol. 75, No. 8, Apr. 15, 1995, pp. 2083-2088.Applicant
- Repa, I. et al., “Mortalities Associated with Use of a Commercial Suspension of Polyvinyl Alcohol”, Radiology 1989; 170:395-399.Applicant
- Rump, A. et al., “Pharmacokinetics of Intraarterial Mitomycin C in the Chemoembolisation Treatment of Liver Metastases”, Gen. Pharmac. vol. 27, No. 4, pp. 669-671, 1996.Applicant
- Thanoo, B. C. et al., “Preparation and Properties of Barium Sulphate and Methyl Iothalamate Loaded Poly(vinyl Alcohol) Microspheres as Radiopaque Particulate Emboli”, Journal of Applied Biomaterials, vol. 2, 67-72 (1991).Applicant
- Zou , Ying-hua, et al. “Experimental Canine Hapatic Artery Embolization with Polyvinyl Alcohol Microspheres”, Zhong Hua Fang-She Xue ZaZhi, Dec. 23, 1989 (6):330-332.Applicant
- Zou , Ying-hua, et al. “Experimental Canine Hapatic Artery Embolization with Polyvinyl Alcohol Microspheres” (Translation), Zhong Hua Fang-She Xue ZaZhi, Dec. 23, 1989 (6):330-332.Applicant