High efficacy antibacterial compositions having enhanced esthetic and skin care properties

[0001] This application claims the benefit of U.S. provisional patent application Ser. No. 60/279,949, filed Mar. 29, 2001.

[0002] The present invention relates to antibacterial compositions, like personal care compositions, having high antibacterial effectiveness and excellent esthetic properties, such as foam generation, foam stability, and a capability of imparting skin care properties to cleansed skin. More particularly, the present invention relates to antibacterial compositions comprising an antibacterial agent, a surfactant, a hydrotrope, a hydric solvent, esthetics-enhancing ingredients, and optional skin care ingredients, and that provide a substantial reduction, e.g., greater than 99%, in Gram positive and Gram negative bacteria populations within one minute.

[0003] Antibacterial personal care compositions are known in the art. Especially useful are antibacterial cleansing compositions, which typically are used to cleanse the skin and to destroy bacteria and other microorganisms present on the skin, especially the hands, arms, and face of the user.

[0004] Antibacterial compositions are used, for example, in the health care industry, food service industry, meat processing industry, and in the private sector by individual consumers. The wide-spread use of antibacterial compositions indicates the importance consumers place on controlling bacteria and other microorganism populations on skin. It is important, however, that antibacterial compositions provide a substantial and broad spectrum reduction in microorganism populations quickly and without problems associated with toxicity and skin irritation.

[0005] In particular, antibacterial cleansing compositions typically contain an active antibacterial agent, a surfactant, and various other ingredients, for example, dyes, fragrances, pH adjusters, thickeners, and the like, in an aqueous carrier. Several different classes of antibacterial agents have been used in antibacterial cleansing compositions. Examples of antibacterial agents include a bisguanidine (e.g., chlorhexidine digluconate), diphenyl compounds, benzyl alcohols, trihalocarbanilides, quaternary ammonium compounds, ethoxylated phenols, and phenolic compounds, such as halo-substituted phenolic compounds, like PCMX (i.e., p-chloro-m-xylenol) and triclosan (i.e., 2,4,4′-tri-chloro-2′hydroxy-diphenylether). Present-day antimicrobial compositions based on such antibacterial agents exhibit a wide range of antibacterial activity, ranging from low to high, depending on the microorganism to be controlled and the particular antibacterial composition.

[0006] Most commercial antibacterial compositions, however, generally offer a low to moderate antibacterial activity. Antibacterial activity is assessed against a broad spectrum of microorganisms, including both Gram positive and Gram negative microorganisms. The log reduction, or alternatively the percent reduction, in bacterial populations provided by the antibacterial composition correlates to antibacterial activity. A log reduction of 3-5 is most preferred, a 1-3 reduction is preferred, whereas a log reduction of less than 1 is least preferred, for a particular contact time, generally ranging from 15 seconds to 5 minutes. Thus, a highly preferred antibacterial composition exhibits a 3-5 log reduction against a broad spectrum of micro-organisms in a short contact time. Prior disclosures illustrate attempts to provide such antibacterial compositions, which, to date, do not provide the rapid, broad range control of microorganisms desired by consumers.

[0007] It should be noted that high log reductions have been achieved at pH values of 4 and 9, but such log reductions are attributed at least in part to these relatively extreme pH values. Compositions having such pH values can irritate the skin and other surfaces, and, therefore, typically are avoided. It has been difficult to impossible to achieve a high log reduction using an antibacterial composition having a neutral pH of about 5 to about 8, and especially about 6 to about 8.

[0008] However, highly efficacious antibacterial compositions suffer in comparison to regular (i.e., nonantibacterial) personal care compositions with respect to acceptable consumer properties, especially foam characteristics and imparting skin care properties, such as skin conditioning. It also is difficult to provide phase stable, highly efficacious antibacterial compositions having consumer-acceptable esthetics. Further, present-day antibacterial personal care compositions do not provide an effective antibacterial activity, especially against pathogenic Gram negative bacteria. Thus, a need exists for phase stable, efficacious antibacterial personal care compositions containing skin care ingredients, and that further are consumer acceptable.

[0009] An example of patents and published applications disclosing compositions comprising triclosan, surfactants, solvents, chelating agents, thickeners, buffering agents, and water is WO 98/01110. WO 98/01110 is directed to reducing skin irritation by employing a reduced amount of surfactant.

[0010] Fendler et al. U.S. Pat. No. 5,635,462 discloses compositions comprising PCMX and selected surfactants. The compositions disclosed therein are devoid of anionic surfactants and nonionic surfactants.

[0011] WO 97/46218 and WO 96/06152 disclose compositions based on triclosan, organic acids or salts, hydrotropes, and hydric solvents.

[0012] EP 0 505 935 discloses compositions containing PCMX in combination with nonionic and anionic surfactants, particularly nonionic block copolymer surfactants.

[0013] WO 95/32705 discloses a mild surfactant combination that can be combined with antibacterial compounds, like triclosan.

[0014] WO 95/09605 discloses antibacterial compositions containing anionic surfactants and alkyl-polyglycoside surfactants.

[0015] WO 98/55096 discloses antimicrobial wipes having a porous sheet impregnated with an antibacterial composition containing an active antimicrobial agent, an anionic surfactant, an acid, and water, wherein the composition has a pH of about 3.0 to about 6.0.

[0016] Glenn, Jr. et al. U.S. Pat. No. 5,885,948 discloses a stress stable, lathering skin cleansing composition containing about one to 30 parts lipid skin moisturizing agents.

[0017] Beerse et al. U.S. Pat. Nos. 5,968,539; 6,106,851; and 6,113,933 disclose antibacterial compositions having a pH of about 3 to about 6. The compositions contain an antibacterial agent, an anionic surfactant, and a proton donor.

[0018] N. A. Allawala et al., J. Amer. Pharm. Assoc.—Sci. Ed., Vol. XLII, no. 5, pp. 267-275, (1953) discusses the antibacterial activity of active antibacterial agents in combination with surfactants.

[0019] A. G. Mitchell, J. Pharm. Pharmacol., Vol. 16, pp. 533-537, (1964) discloses compositions containing PCMX and a nonionic surfactant that exhibit antibacterial activity. The compositions disclosed in the Mitchell publication exhibit antibacterial activity in at least 47 minutes contact time, thus the compositions are not highly effective.

[0020] Prior disclosures have not addressed the issue of providing an antibacterial composition that (a) affords an effective, fast, and broad spectrum control of bacteria at a neutral pH of about 5 to about 8, and especially at about 6 to about 8, (b) is phase stable, (c) exhibits excellent esthetic properties, such as a stable, copious foam generation, and (d) imparts skin care properties to cleansed skin. In addition to the above, prior disclosures also have not addressed providing a composition of sufficiently low viscosity for use with a self-foaming pump.

[0021] An efficacious antibacterial composition has been difficult to achieve because of the properties of the antibacterial agents and the effects of a surfactant, a hydrotrope, and a hydric solvent on an antibacterial agent. One such efficacious antibacterial composition is discussed in Taylor et al. U.S. Pat. No. 6,107,261, incorporated herein by reference. This patent discloses a highly efficacious antibacterial composition against Gram negative and Gram positive bacteria, and containing a high percent (at least 25%) saturation of a phenolic antibacterial agent. The positive effects of a higher percent of saturation of antibacterial agent is fully discussed in U.S. Pat. No. 6,107,261.

[0022] A need now exists for an antibacterial composition that is highly efficacious against a broad spectrum of Gram positive and Gram negative bacteria in a short time period, wherein the antibacterial activity is attributed primarily, or solely, to the presence of the active antibacterial agent in the composition, and has consumer-acceptable esthetic properties with respect to phase stability, feel, foam generation and stability, and imparting skin care properties. The present invention is directed to such efficacious and esthetically pleasing antibacterial compositions.

[0023] The development of such compositions is difficult because of factors such as a) the need for a high antimicrobial efficacy even in the presence of esthetic enhancing and skin care additives, b) the need to maintain a relatively high % saturation of the antibacterial agent, and c) the difficulty in formulating a high-foaming composition in the presence of significant amounts of a hydrotrope and hydric solvent. Unlike present-day commercial compositions and compositions disclosed in the prior art, the variety, type, and amounts of esthetic enhancing and skin care additives that can be incorporated in the present compositions are varied and unexpected, and a high percent saturation of antibacterial agent can be maintained.

[0024] In addition, antibacterial composition viscosity also is critical for particular applications. For example, a preferred method of using the composition is with a self-foaming pump. If the viscosity of the composition is too high (e.g., greater than about 50 centipoise), the composition cannot be pumped through a preferred foaming device. Finally, foam generation and stability also are important for consumer acceptability. Compositions of the present invention exhibit excellent viscosity, enhanced foam volume, creaminess, and slip during human use tests. This is especially important for application of the antibacterial composition to dry hands through a foaming pump, followed by about 30 seconds lathering, and completed by rinsing with water. This type of application provides the highest antibacterial effect.

[0025] The present invention is directed to antibacterial compositions that provide a substantial reduction in Gram positive and Gram negative bacteria in less than about one minute. More particularly, the present invention is directed to antimicrobial compositions containing an active antibacterial agent, a surfactant, and water, in addition to ingredients such as emollients, humectants, and foam stabilizers to impart esthetics to the composition and skin care properties to cleansed skin. The antibacterial agent is present in the composition in an amount of at least 25% of saturation, when measured at room temperature. The present antimicrobial compositions are phase stable, and can be designed to have a viscosity suitable for a variety of end uses, including a composition for use with a self-foaming pump and a composition that is applied to the skin neat, lathered to cleanse the skin and kill bacteria, followed by rinsing from the skin.

[0026] Accordingly, one aspect of the present invention is to provide an antibacterial composition, wherein the composition comprises:

[0027] (a) about 0.001% to about 10%, by weight, of an antimicrobial agent;

[0028] (b) about 0.1% to about 40%, by weight, of a surfactant selected from the group consisting of an anionic surfactant, a cationic surfactant, a nonionic surfactant, an ampholytic surfactant, and mixtures thereof;

[0029] (c) about 1% to about 40%, by weight, of a hydrotrope;

[0030] (d) about 1% to about 25%, by weight, of a water-soluble hydric solvent; and

[0031] (e) 0% to about 5%, by weight, of a skin care agent;

[0032] (f) 0% to about 5%, by weight, of a foam stabilizer;

[0033] (g) 0% to about 5%, by weight, of a humectant; and

[0034] (h) water,

[0035] wherein the composition contains at least one of (e), (f), and (g), and wherein the antimicrobial agent is present in the composition in an amount of at least 25% of saturation concentration, when measured at room temperature.

[0036] Another aspect of the present invention is to provide an antibacterial composition that exhibits a log reduction against Gram positive bacteria (i.e., S. aureus) of at least 2 after 30 seconds of contact.

[0037] Still another aspect of the present invention is to provide an antibacterial composition that exhibits a log reduction against Gram negative bacteria (i.e., E. coli) of at least 2.5 after 30 seconds of contact.

[0038] Another aspect of the present invention is to provide an antibacterial composition that exhibits a substantial log reduction against Gram positive and Gram negative bacteria, and has a pH of about 5 to about 8.

[0039] A present antibacterial composition is phase stable, and typically has a viscosity of about 0.1 to about 50 centipoise (cp). However, in the presence of an optional thickener, the viscosity can be up to about 10,000. The present compositions also exhibit excellent esthetic properties, such as foam height and foam stability. The present compositions further impart skin conditioning and improved skin feel to cleansed skin. These improved esthetic and skin care properties are unexpected in antibacterial compositions because skin care and esthetic ingredients are difficult to incorporate into antibacterial compositions, and especially difficult to incorporate without adversely affecting the antibacterial efficacy of the composition.

[0040] Another aspect of the present invention is to provide consumer products based on an antibacterial composition of the present invention, for example, a skin cleanser, a body splash, a surgical scrub, a wound care agent, a hand sanitizer gel, a disinfectant, a mouth wash, a pet shampoo, a hard surface sanitizer, and the like. The present compositions can be applied, then either rinsed off, wiped off, or allowed to remain on the skin.

[0041] A further aspect of the present invention is to provide a method of reducing the Gram positive and/or Gram negative bacteria populations on animal tissue, including human tissue, by contacting the tissue, like the dermis, with a composition of the present invention for a sufficient time, such as about 15 seconds to 5 minutes, to reduce the bacteria level to a desired level.

[0042] The above and other novel aspects and advantages of the present invention are illustrated in the following, nonlimiting detailed description of the preferred embodiments.

[0046] Personal care products incorporating an active antibacterial agent have been known for many years. Since the introduction of antibacterial personal care products, many claims have been made that such products provide antibacterial properties. However, to be most effective, an antibacterial composition should provide a high log reduction against a broad spectrum of organisms in as short a contact time as possible.

[0047] The antibacterial composition also should exhibit excellent esthetic properties and impart skin care properties in order to achieve consumer acceptance. The features of antibacterial efficacy, esthetics, and skin care often are competing, wherein enhancing one feature is detrimental to the other. The present invention is directed to antibacterial compositions that unexpectedly exhibit all of these features.

[0048] As presently formulated, most commercial liquid antibacterial soap compositions provide a poor to marginal time kill efficacy, i.e., rate of killing bacteria. Table 1 summarizes the kill efficacy of commercial products, each of which contains about 0.2% to 0.3%, by weight, triclosan (an antibacterial agent).

[0049]

TABLE 1
Time Kill Efficacy of Commercial Liquid Hand Soaps
(log reduction after 1 minute contact time)
		Gram	Gram	Gram
		positive	negative	negative
	Product	S. aureus	E. Coli	K. pneum.
	Commercial Product A	1.39	0.00	0.04
	Commercial Product B	2.20	0.00	0.01
	Commercial Product C	1.85	0.00	0.00
	Commercial Product D	2.79	0.26	—

[0050] Present-day products especially lack efficacy against Gram negative bacteria, such as E. coli, which are of particular concern to human health. For example, note that Commercial Product D of Table 1, referred to as a “moisturizing antimicrobial” product is ineffective versus E. coli in a time-kill test. The present invention, therefore, is directed to antibacterial compositions having an exceptionally high broad spectrum antibacterial efficacy, as measured by a rapid kill of bacteria (i.e., time kill), which is to be distinguished from persistent kill, and that provides consumer-acceptable esthetic properties.

[0051] The present antibacterial compositions provide significantly improved time kill efficacy compared to prior compositions. The basis of this improved time kill is the discovery that the antimicrobial efficacy of an active agent can be correlated to the rate at which the agent has access to an active site on the microbe. The driving force that determines the rate of agent transport to the site of action is the difference in chemical potential between the site at which the agent acts and the external aqueous phase. Alternatively stated, the microbicidal activity of an active agent is proportional to its thermodynamic activity in the external phase. Accordingly, thermodynamic activity, as opposed to concentration, is the more important variable with respect to antimicrobial efficacy. Thermodynamic activity is conveniently correlated to the percent saturation of the active antibacterial agent in the continuous aqueous phase of the composition. This feature is discussed fully in U.S. Pat. No. 6,107,621, incorporated herein by reference.

[0052] The present compositions are antibacterial compositions having an improved effectiveness against both Gram negative and Gram positive bacteria, that exhibit a rapid bacteria kill, that exhibit excellent esthetics, and that impart skin conditioning and improved feel to cleansed skin. As illustrated in the following embodiments, an antibacterial composition of the present invention comprises: (a) about 0.001% to about 10%, by weight, of an antibacterial agent; (b) about 0.1% to about 40%, by weight, of a surfactant; (c) about 1% to about 40%, by weight, of a hydrotrope; (d) about 1% to about 25%, by weight, of a hydric solvent; (e) 0% to about 5%, by weight, of a skin care agent; (f) 0% to about 2%, by weight, of a foam stabilizer; (g) 0% to about 5%, by weight, of a humectant; and (h) water, wherein the composition contains at least one of (e), (f), and (g).

[0053] The compositions have a percent saturation of antibacterial agent in the continuous aqueous phase of at least about 25%, when measured at room temperature. The compositions exhibit a log reduction against Gram positive bacteria of at least about 2 after 30 seconds contact. The compositions exhibit a log reduction against Gram negative bacteria of at least about 2.5 after 30 seconds contact. The compositions also exhibit excellent composition esthetics, e.g., foam characteristics, and viscosity. The compositions further impart skin conditioning properties and improved feel to cleansed skin.

[0054] Embodiments of the present invention comprise (a) an active antibacterial agent, (b) a surfactant, (c) a hydrotrope, (d) a hydric solvent, (e) at least one of a skin care agent, a foam stabilizer, and a humectant, and (f) water. The presence of a hydric solvent, hydrotrope, skin care agent, foam stabilizer, and humectant do not adversely affect the antimicrobial properties of the composition. The compositions are phase stable, and exhibit excellent esthetic properties, such as foam generation and stability, and impart excellent skin conditioning properties and skin feel. The compositions can further include additional optional ingredients disclosed hereafter, such as thickeners, preservatives, pH adjusters, dyes, and perfumes.

[0055] In particular, the present invention is directed to antibacterial compositions, especially for use in personal care, but also suitable as disinfectants, surgical scrubs, hospital hand wash products, hand sanitizer gels, wound care agents, and the like. The present compositions comprise about 0.001% to about 10% of a phenolic antibacterial agent, preferably triclosan or PCMX, dissolved in an aqueous vehicle and further containing a surfactant, solvent, hydrotrope, and at least one of a skin care agent, foam stabilizer, and humectant. The surfactant, solvents, and hydrotropes are present in amounts such that the percent saturation of the phenolic antibacterial agent in the composition is at least 25%, preferably greater than about 50%, and most preferably greater than about 95% (see U.S. Pat. No. 6,107,261). The foam stabilizing, skin care, and humectant additives are selected from compounds including, but not limited to, polymers, protein derivatives, silicone derivatives, ethoxylated derivatives, long-chain fatty materials, and lipid-like materials. The present compositions exhibit new and unexpected properties, like mildness, skin after-feel, foaming properties, and other properties required, or at least desired, by consumers.

[0056] As demonstrated in more detail hereafter, a preferred embodiment contains, by weight, about 0.3% to about 1.0% triclosan, about 5% to about 15% dipropylene glycol, about 10% to about 40% sodium xylene sulfonate, about 0.5% to about 5% ammonium lauryl sulfate, 0% to about 5% cocamidopropyl betaine, and one or more of 0% to about 3% sodium PCA, 0% to about 0.5% cetyl or cetearyl alcohol, 0% to about 0.5% polyquaternium-10, 0% to about 5% glycerin, and 0% to about 1% aloe.

[0057] A. Antibacterial Agent

[0058] An antibacterial agent is present in a composition of the present invention in an amount of about 0.001% to about 10%, and preferably about 0.01% to about 5%, by weight of the composition. To achieve the full advantage of the present invention, the antibacterial agent is present in an amount of about 0.05% to about 2%, by weight, of the composition.

[0059] The antibacterial compositions can be ready to use compositions, which typically contain 0.001% to about 2%, preferably 0.01% to about 1.5%, and most preferably about 0.05% to about 1%, of an antibacterial agent, by weight of the composition. The antibacterial compositions also can be formulated as concentrates that are diluted before use with one to about 100 parts water to provide an end use composition. The concentrated compositions typically contain greater than about 0.1% and up to about 10%, by weight, of the antibacterial agent. Applications also are envisioned wherein the end use composition contains greater than 2%, by weight, of the antibacterial agent.

[0060] As discussed in U.S. Pat. No. 6,107,261, the absolute amount of antibacterial agent present in the composition is not as important as the amount of available antibacterial agent in the composition. The amount of available antibacterial agent in the composition is related to the identity and amount of In ingredients in the composition.

[0061] To achieve the desired bacteria kill in a short contact time, like 15 to 60 seconds, the composition contains an amount of antibacterial agent that is at least about 25%, and preferably at least about 50%, of the saturation concentration of the antibacterial agent in the composition, when measured at room temperature. To achieve the full advantage of the present invention, the composition is at least 75%, and more preferably about 95% to 100%, saturated with the antibacterial agent. The method of determining percent saturation of antibacterial agent in the composition is disclosed hereafter.

[0062] The antimicrobial agents useful in the present invention are phenolic compounds exemplified by the following classes of compounds:
(a) 2-Hydroxydiphenyl Compounds
wherein Y is chlorine or bromine, Z is SO₂H, NO₂, or C₁-C₄ alkyl, r is 0 to 3, o is 0 to 3, p is 0 or 1, m is 0 or 1, and n is 0 or 1.

[0063] In preferred embodiments, Y is chlorine or bromine, m is 0, n is 0 or 1, o is 1 or 2, r is 1 or 2, and p is 0.

[0064] In especially preferred embodiments, Y is chlorine, m is 0, n is 0, o is 1, r is 2, and p is 0.

[0065] A particularly useful 2-hydroxydiphenyl compound has the structure:
having the adopted name, triclosan, and available commercially under the tradename IRGASAN DP300, from Ciba Specialty Chemicals Corp., Greensboro, N.C. Another useful 2-hydroxydiphenyl compound is 2,2′-dihydroxy-5,5′-dibromo-diphenyl ether. Additional bisphenolic compounds are disclosed in U.S. Pat. No. 6,113,933, incorporated herein by reference.
(b) Phenol Derivatives
wherein R₁ is hydro, hydroxy, C₁-C₄ alkyl, chloro, nitro, phenyl, or benzyl; R₂ is hydro, hydroxy, C₁-C₆ alkyl, or halo; R₃ is hydro, C₁-C₆ alkyl, hydroxy, chloro, nitro, or a sulfur in the form of an alkali metal salt or ammonium salt; R₄ is hydro or methyl, and R₅ is hydro or nitro. Halo is bromo or, preferably, chloro.

[0066] Specific examples of phenol derivatives include, but are not limited to, chlorophenols (o-, m-, p-), 2,4-dichlorophenol, p-nitrophenol, picric acid, xylenol, p-chloro-m-xylenol, cresols (o-, m-, p-), p-chloro-m-cresol, pyrocatechol, resorcinol, 4-n-hexylresorcinol, pyrogallol, phloroglucin, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-benzylphenol, p-chloro-o-benzylphenol, phenol, 4-ethylphenol, and 4-phenolsulfonic acid. Other phenol derivatives are listed in WO 98/55096 and U.S. Pat. No. 6,113,933, incorporated herein by reference.
(c) Diphenyl Compounds
wherein X is sulfur or a methylene group, R₁ and R′₁ are hydroxy, and R₂, R′₂, R₃, R′₃, R₄, R′₄, R₅, and R′₅, independent of one another, are hydro or halo. Specific, nonlimiting examples of diphenyl compounds are hexachlorophene, tetrachlorophene, dichlorophene, 2,3-dihydroxy-5,5′-dichlorodiphenyl sulfide, 2,2′-dihydroxy-3,3′,5,5′-tetrachlorodiphenyl sulfide, 2,2′-dihydroxy-3,5′,5,5′,6,6′-hexachlorodiphenyl sulfide, and 3,3′-dibromo-5,5′-dichloro-2,2′-dihydroxydiphenylamine. Other diphenyl compounds are listed in WO 98/55096, incorporated herein by reference.

[0067] B. Surfactant

[0068] In addition to the antibacterial agent, a present antimicrobial composition also contains a surfactant. The surfactant is present in an amount of about 0.1% to about 40%, and preferably about 0.3% to about 20%, by weight, of the composition. To achieve the full advantage of the present invention, the antibacterial composition contains about 0.5% to about 15%, by weight, of the surfactant.

[0069] Ready-to-use compositions typically contain about 0.1% to about 10%, preferably about 0.3% to about 5%, and most preferably, 0.5% to about 3%, by weight, of the composition. Concentrated compositions suitable for dilution typically contain greater than about 5%, by weight, of a surfactant.

[0070] The amount of surfactant present in the composition is related to the amount and identity of the antibacterial agent in the composition and to the identity of the surfactant. The amount of surfactant is determined such that the percent saturation of the antibacterial agent in the composition is at least about 50%, preferably at least about 75%, and most preferably at least about 95% up to 100%.

[0071] The surfactant can be an anionic surfactant, a cationic surfactant, a nonionic surfactant, or a compatible mixture of surfactants. The surfactant also can be an ampholytic or amphoteric surfactant, which have anionic or cationic properties depending upon the pH of the composition.

[0072] The antibacterial compositions, therefore, can contain any anionic surfactant having a hydrophobic moiety, such as a carbon chain including about 8 to about 30 carbon atoms, and particularly about 12 to about 20 carbon atoms, and further has a hydrophilic moiety, such as sulfate, sulfonate, carbonate, phosphate, or carboxylate. Often, the hydrophobic carbon chain is etherified, such as with ethylene oxide or propylene oxide, to impart a particular physical property, such as increased water solubility or reduced surface tension to the anionic surfactant.

[0073] Therefore, suitable anionic surfactants include, but are not limited to, compounds in the classes known as alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, sulfate esters of an alkylphenoxy polyoxyethylene ethanol, alpha-olefin sulfonates, beta-alkoxy alkane sulfonates, alkylaryl sulfonates, alkyl monoglyceride sulfates, alkyl monoglyceride sulfonates, alkyl carbonates, alkyl ether carboxylates, fatty acids, sulfosuccinates, sarcosinates, octoxynol or nonoxynol phosphates, taurates, fatty taurides, fatty acid amide polyoxyethylene sulfates, isethionates, or mixtures thereof. Additional anionic surfactants are listed in McCutcheon's Emulsifiers and Detergents, 1993 Annuals, (hereafter McCutcheon's), McCutcheon Division, MC Publishing Co., Glen Rock, N.J., pp. 263-266, incorporated herein by reference. Numerous other anionic surfactants, and classes of anionic surfactants, are disclosed in Laughlin et al. U.S. Pat. No. 3,929,678, incorporated herein by reference.

[0074] Examples of anionic surfactants include a C₈-C₁₈ alkyl sulfate, a C₈-C₁₈ fatty acid salt, a C₈-C₁₈ alkyl ether sulfate having one or two moles of ethoxylation, a C₈-C₁₈ alkamine oxide, a C₈-C₁₈ alkyl sarcosinate, a C₈-C₁₈ sulfoacetate, a C₈-C₁₈ sulfosuccinate, a C₈-C₁₈ alkyl diphenyl oxide disulfonate, a C₈-C₁₈ alkyl carboxylate, a C₈-C₁₈ alpha-olefin sulfonate, a methyl ester sulfonate, and mixtures thereof. The C₈-C₁₈ alkyl group contains eight to sixteen carbon atoms, and can be straight chain (e.g., lauryl) or branched (e.g., 2-ethylhexyl). The cation of the anionic surfactant can be an alkali metal (preferably sodium or potassium), ammonium, C₁-C₄ alkylammonium (mono-, di-, tri), or C₁-C₃ alkanolammonium (mono-, di-, tri-). Lithium and alkaline earth cations (e.g., magnesium) can be used, but antibacterial efficacy is reduced.

[0075] Specific surfactants include, but are not limited to, lauryl sulfates, octyl sulfates, 2-ethylhexyl sulfates, lauramine oxide, decyl sulfates, tridecyl sulfates, cocoates, lauroyl sarcosinates, lauryl sulfosuccinates, linear C₁₀ diphenyl oxide disulfonates, lauryl sulfosuccinates, lauryl ether sulfates (1 and 2 moles ethylene oxide), myristyl sulfates, oleates, stearates, tallates, cocamine oxide, decylamine oxide, myristamine oxide, ricinoleates, cetyl sulfates, and similar surfactants.

[0076] The antibacterial compositions also can contain nonionic surfactants. Typically, a nonionic surfactant has a hydrophobic base, such as a long chain alkyl group or an alkylated aryl group, and a hydrophilic chain comprising a sufficient number (i.e., 1 to about 30) of ethoxy and/or propoxy moieties. Examples of classes of nonionic surfactants include ethoxylated alkylphenols, ethoxylated and propoxylated fatty alcohols, polyethylene glycol ethers of methyl glucose, polyethylene glycol ethers of sorbitol, ethylene oxide-propylene oxide block copolymers, ethoxylated esters of fatty (C₈-C₁₈) acids, condensation products of ethylene oxide with long chain amines or amides, and mixtures thereof.

[0077] Exemplary nonionic surfactants include, but are not limited to, methyl gluceth-10, PEG-20 methyl glucose distearate, an alkyl polyglucoside (APG), like decyl polyglucoside or lauryl polyglucoside, PEG-20 methyl glucose sesquistearate, C_11-15 pareth-20, ceteth-8, ceteth-12, dodoxynol-12, laureth-15, PEG-20 castor oil, polysorbate 20, steareth-20, polyoxyethylene-10 cetyl ether, polyoxyethylene-10 stearyl ether, polyoxyethylene-20 cetyl ether, polyoxyethylene-10 oleyl ether, polyoxyethylene-20 oleyl ether, an ethoxylated nonylphenol, ethoxylated octylphenol, ethoxylated dodecylphenol, or ethoxylated fatty (C₆-C₂₂) alcohol, including 7 to 20 ethylene oxide moieties, polyoxyethylene-20 isohexadecyl ether, polyoxyethylene-23 glycerol laurate, polyoxy-ethylene-20 glyceryl stearate, PPG-10 methyl glucose ether, PPG-20 methyl glucose ether, polyoxyethylene-20 sorbitan mono-esters, polyoxyethylene-80 castor oil, polyoxyethylene-15 tridecyl ether, polyoxy-ethylene-6 tridecyl ether, PEG 600 dioleate, PEG 400 dioleate, and mixtures thereof.

[0078] Numerous other nonionic surfactants are disclosed in McCutcheonrs Detergents and Emulsifiers, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, N.J., pp. 1-246 and 266-272; in the CTFA International Cosmetic Ingredient Dictionary, Fourth Ed., Cosmetic, Toiletry and Fragrance Association, Washington, D.C. (1991) (hereinafter the CTFA Dictionary) at pages 1-651; and in the CTFA Handbook, at pages 86-94, each incorporated herein by reference.

[0079] In addition to anionic and nonionic surfactants, cationic, ampholytic, and amphoteric surfactants can be used in the antimicrobial compositions.

[0080] Ampholytic surfactants can be broadly described as derivatives of secondary and tertiary amines having aliphatic radicals that are straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and at least one of the aliphatic substituents contains an anionic water-solubilizing group, e.g., carboxy, sulfonate, or sulfate. Examples of compounds falling within this description are sodium 3-(dodecylamino)propionate, sodium 3-(dodecylamino)-propane-1-sulfonate, sodium 2-(dodecylamino)ethyl sulfate, sodium 2-(dimethylamino)octadecanoate, di-sodium 3-(N-carboxymethyl-dodecylamino)propane-1-sulfonate, disodium octadecyliminodiacetate, sodium 1-carboxymethyl-2-undecylimidazole, and sodium N,N-bis(2-hydroxyethyl)-2-sulfato-3-dodecoxypropylamine.

[0081] More particularly, one class of ampholytic surfactants include sarcosinates and taurates having the general structural formula
wherein R¹ is C₁₁ through C₂₁ alkyl, R² is hydrogen or C₁-C₂ alkyl, Y is CO₂M or SO₃M, M is an alkali metal, and n is a number 1 through 3.

[0082] Another class of ampholytic surfactants is the amide sulfosuccinates having the structural formula

[0083] The following classes of ampholytic surfactants also can be used:
Additional classes of ampholytic surfactants include the phosphobetaines and the phosphitaines.

[0084] Specific, nonlimiting examples of ampholytic surfactants useful in the present invention are sodium coconut N-methyl taurate, sodium oleyl N-methyl taurate, sodium tall oil acid N-methyl taurate, sodium palmitoyl N-methyl taurate, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylcarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, lauryl-bis-(2-hydroxyethyl)carboxymethylbetaine, oleyldimethylgammacarboxypropylbetaine, lauryl-bis-(2-hydroxypropyl)-carboxyethylbetaine, cocoamidodimethylpropylsultaine, stearylamidodimethylpropylsultaine, laurylamido-bis-(2-hydroxyethyl)propylsultaine, disodium oleamide PEG-2 sulfosuccinate, TEA oleamido PEG-2 sulfosuccinate, disodium oleamide MEA sulfosuccinate, disodium oleamide MIPA sulfosuccinate, disodium ricinoleamide MEA sulfosuccinate, disodium undecylenamide MEA sulfosuccinate, disodium wheat germamido MEA sulfosuccinate, disodium wheat germamido PEG-2 sulfosuccinate, disodium isostearamideo MEA sulfosuccinate, cocoamphoglycinate, cocoamphocarboxyglycinate, lauroamphoglycinate, lauroamphocarboxyglycinate, capryloamphocarboxyglycinate, cocoamphopropionate, cocoamphocarboxypropionate, lauroamphocarboxypropionate, capryloamphocarboxypropionate, dihydroxyethyl tallow glycinate, cocamido disodium 3-hydroxypropyl phosphobetaine, lauric myristic amido disodium 3-hydroxypropyl phosphobetaine, lauric myristic amido glyceryl phosphobetaine, lauric myristic amido carboxy disodium 3-hydroxypropyl phosphobetaine, cocoamido propyl mono-sodium phosphitaine, lauric myristic amido propyl monosodium phosphitaine, and mixtures thereof.

[0085] The surfactant also can be a cationic alkamine oxide surfactant. An alkamine oxide useful in the present invention contains at least one long hydrocarbon chain containing at least eight carbon atoms. One class of amine oxides is the alkyl di-(lower alkyl) amine oxides, wherein the alkyl group contains 8 to 22, and preferably about 10 to about 16, carbon atoms, and can be straight or branched chain, saturated or unsaturated. The lower alkyl groups contain 1 to 7 carbon atoms, and typically are methyl. Specific examples include, but are not limited to, lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, dimethyl cocoamine oxide, dimethyl (hydrogenated tallow)amine oxide, myristyl/palmityl dimethyl amine oxide, myristyl/lauryl dimethyl amine oxide, cetyl dimethyl amine oxide, stearyl dimethyl amine oxide, and myristyl/cetyl dimethyl amine oxide. These alkamine oxides have a general structural formula

[0086] Another class of useful amine oxides includes alkyl di(hydroxy lower alkyl)amine oxides in which the alkyl group contains 8 to 22, and preferably about 10 to about 16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. Specific examples, include, but are not limited to, bis(2-hydroxyethyl)cocoamine oxide, bis-(2-hydroxyethyl)tallow amine oxide, and bis(2-hydroxyethyl)stearylamine oxide. These alkamine oxides have a general structural formula

[0087] Additional useful amine oxides are termed alkamidopropyl di(lower alkyl)amine oxides in which the alkyl group contains 8 to 22, and preferably about 10 to about 16 carbon atoms, and can be straight or branched chain, saturated or unsaturated. Examples are cocoamidopropyl dimethyl amine oxide and tallowamidopropyl dimethyl amine oxide. These alkamine oxides have a general structural formula

[0088] Further useful amine oxides are termed alkylmorpholine oxides in which the alkyl group contains 8 to 22, and preferably about 10 to about 16, carbon atoms, and can be straight or branched chain, saturated or unsaturated. Alkamine oxides are commercially available, for example, from Stepan Co., Northfield, Ill., and Lonza Inc., Fairlawn, N.J.

[0089] The above classes of alkamine oxide surfactants contain a C₁-C₂₂alkyl group selected from, for example, octyl, decyl, undecyl, lauryl, tri-decyl, myristyl, cetyl, stearyl, isostearyl, oleyl, and mixtures thereof. Examples of amine oxide surfactants include, but are not limited to, decyl dimethylamine oxide, lauryl dimethylamine oxide, stearyl dimethylamine oxide, oleyl dimethylamine oxide, coco dihydroxyethylamine oxide, cetyl N,N-dihydroxyethyl amine oxide, oleyl N,N-dihydroxyethylamine oxide, cocamine oxide, cocamidopropylamine oxide, lauramidopropylamine oxide, oleamine oxide, oleamidopropylamine oxide, wheat germamidopropylamine oxide, isostearamidopropylamine oxide, stearamine oxide, stearamidopropylamine oxide, cocomorpholine oxide, decylamine oxide, dihydroxyethyl C₈-C₁₀-alkoxypropylamine oxide, dihydroxyethyl C₉-C₁₁alkoxypropylamine oxide, dihydroxyethyl C₁₂-C₁₅alkoxypropylamine oxide, dihydroxyethyl cocamine oxide; dihydroxyethyl stearamine oxide, dihydroxyethyl tallowamine oxide, hydrogenated tallow amine oxide, hydroxyethyl hydroxypropyl C₁₂-C₁₅alkoxypropylamine oxide, isostearamidopropyl morpholine oxide, myristamidopropylamine oxide, myristamine oxide, palmitamidopropylamine oxide, palmitamine oxide, PEG-3 lauramine oxide, tallow amidopropylamine oxide, tallow amine oxide, undecylenamidopropylamine oxide, and mixtures thereof. Preferred alkamine oxide surfactants are the alkyl di(lower alkyl)amine oxides in which the alkyl group contains about 12 to about 16 carbon atoms, including lauramine oxide, myristamine oxide, cocamine oxide, cetamine oxide, and mixtures thereof. Most preferably, the alkamine oxide surfactant comprises lauramine oxide.

[0090] Additional cationic surfactants include a quaternary surfactant having a structural formula
a quaternized phosphate ester, such as PHOSPHOLIPID SV, available from Mona Industries, Paterson, N.J., e.g., stearamidopropyl phosphatidyl PG-dimonium chloride, linoleamidopropyl phosphatidyl PG-dimonium chloride, coco phosphatidyl PG-dimonium chloride, cocamidopropyl phosphatidyl PG-dimonium chloride, borageamidopropyl phosphatidyl PG-dimonium chloride, and cocohydroxyethyl phosphatidyl PG-imidazolinium chloride; and other quaternized phosphate esters disclosed in Mayhew et al. U.S. Pat. No. 4,209,449. Additional quaternary ammonium surfactants can be found in the CTFA Handbook at pages 40-42, incorporated herein by reference.

[0091] C. Hydric Solvent and Hydrotrope

[0092] The present invention also contains about 1% to about 25%, by weight, of a hydric solvent, and 1% to about 40%, by weight, of a hydrotrope.

[0093] Preferred embodiments contain about 2% to about 20%, by weight, of a hydric solvent and about 2% to about 25%, by weight, of a hydrotrope. Most preferred embodiments contain about 5% to about 15%, by weight, of a hydric solvent and about 5% to about 20%, by weight, of a hydrotrope.

[0094] As defined herein, the term “hydric solvent” is a water-soluble organic compound containing one to six, and typically one to three, hydroxyl groups. The term “hydric solvent,” therefore, encompasses water-soluble alcohols and diols. Specific examples of hydric solvents include, but are not limited to, methanol, ethanol, isopropyl alcohol, n-butanol, n-propyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, butylene glycol, PEG-4, and similar hydroxyl-containing compounds.

[0095] A hydrotrope is a compound that has the ability to enhance the water solubility of other compounds. A hydrotrope utilized in the present invention lacks surfactant properties, and typically is a short-chain alkyl aryl sulfonate. Specific examples of hydrotropes includes, but are not limited to, sodium cumene sulfonate, ammonium cumene sulfonate, ammonium xylene sulfonate, potassium toluene sulfonate, sodium toluene sulfonate, sodium xylene sulfonate, toluene sulfonic acid, and xylene sulfonic acid. Other useful hydrotropes include sodium polynaphthalene sulfonate, sodium polystyrene sulfonate, sodium methyl naphthalene sulfonate, and disodium succinate.

[0096] D. Skin Care Agent

[0097] An antibacterial composition of the present invention also can contain 0% to about 5%, and preferably 0.1% to about 3%, by weight, of a skin care agent. To achieve the full advantage of the present invention, the composition contains about 0.2% to about 2.5%, by weight, of a skin care agent.

[0098] The identity of the skin care agent is not particularly limited, as long as the agent does not adversely affect the stability or efficacy of the composition. One important class of skin care agents is emollients. Emollients are cosmetic ingredients that help to maintain a soft, smooth, and pliable skin appearance. Emollients function by remaining on the skin surface or in the stratum corneum to act as lubricants, to reduce flaking, and to improve skin appearance.

[0099] In general, the skin care agent includes polymers (e.g., polyvinylpyrrolidine), protein derivatives (e.g., derivatized hydrolyzed wheat protein), ethoxylated fatty ethers, cellulosics (e.g., hydroxyethylcellulose), and similar skin care agents. For example, suitable skin care agents include, but are not limited to, esters comprising an aliphatic alcohol having 2 to about 18 carbon atoms condensed with an aliphatic or aromatic carboxylic acid including 8 to about 20 carbon atoms, e.g., isopropyl myristate, decyl oleate, and cetearyl isononanate. The ester is either straight chained or branched. Preferably, the ester has a molecular weight of less than about 500 and provides emollient properties.

[0100] Nonlimiting examples of other skin care agents include, but are not limited to, polyvinyl-pyrrolidone, polyquaternium-4, polyquaternium-7, polyquaternium-10, guar gum derivatives, hydroxypropylmethylcellulose, hydroxyethylcellulose, a polyethylene glycol, a methyl ether of a polyethylene glycol, quaternium-79, wheat germamidopropyl hydroxypropyl dimonium hydrolyzed wheat protein, stearyl methicone, dimethicone copolyol, dimethicone propyl PG betaine, poly(sodium styrene sulfonate), sorbitan oleate, steareth-2, steareth-21, isoceteth-20, PEG-7 glyceryl cocoate, PEG-75 lanolin, glycereth-26, PPG-5-ceteth-20, a C₁₂-C₂₀ alcohol, canola oil, glyceryl laurate, triglyceryl monostearate, glyceryl monostearate, vitamin E acetate, sunflower seed amidopropylethyldimonium ethylsulfate, sodium PEG-7 olive oil carboxylate, PPG-1 hydroxyethyl caprylamide, PPG-2 hydroxyethyl cocamide, mineral oil, petrolatum, aloe barbadensis, isostearamidopropylmorpholine lactate, strontium acetate, and palmitamidopropyltrimonium chloride. Additional skin care agents are listed in Appendix A. The above skin care agents can be used alone or in admixture.

[0101] E. Foam Stabilizer

[0102] An antibacterial composition of the present invention also can contain 0% to about 2%, and preferably about 0.05% to about 1.5%, by weight, of a foam stabilizer. To achieve the full advantage of the present invention, the composition contains about 0.1% to about 1%, by weight, of the foam stabilizer.

[0103] The identity of the foam stabilizer is not particularly limited, as long as the stabilizer does not adversely affect the stability and efficacy of the composition. Preferred foam stabilizers are C₁₀-C₂₂ fatty alcohols (e.g., cetyl alcohol) and C₁₀-C₂₂ fatty acids (e.g., stearic acid). Nonlimiting examples of foam stabilizers include, but are not limited to, behenyl alcohol, C_9-11 alcohols, C_12-13 alcohols, C_12-15 alcohols, C_12-16 alcohols, C_14-15 alcohols, capyrlic alcohol, arachidic acid, arachidonic acid, coconut acid, corn acid, cottonseed acid, hydrogenated coconut acid, hydrogenated menhaden acid, hydrogenated tallow acid, hydroxystearic acid, isostearic acid, cetearyl alcohol, cetyl alcohol, coconut alcohol, decyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, behenic acid, capric acid, lauric acid, linoleic acid, linolenic acid, linseed acid, myristic acid, oleic acid, palmitic acid, pelargonic acid, octyldodecanol, undecylenyl alcohol, undecylpentadecanol, myristyl alcohol, oleyl alcohol, palm kernel alcohol, stearyl alcohol, tallow alcohol, tridecyl alcohol, caproic acid, caprylic acid, ricinoleic acid, soy acid, stearic acid, tall oil acid, tallow acid, undecanoic acid, undecylenic acid, and mixtures thereof.

[0104] F. Humectant

[0105] An antibacterial composition of the present invention also can contain 0% to about 2%, and preferably about 0.1% to about 3%, by weight, of a humectant. To achieve the full advantage of the present invention, the composition contains about 0.15% to about 2%, of a humectant.

[0106] The identity of the humectant is not particularly limited as long as the humectant does not adversely affect the stability and efficacy of the composition. A humectant typically is a water-soluble compound of low volatility, and containing a plurality (i.e., two or more) hydroxyl groups. Nonlimiting examples of humectants, include, but are not limited to, ascorbic acid, ascorbyl dipalmitate, acetamide MEA, glucose glutamate, glucuronic acid, TEA-lactate, TEA-PCA, corn syrup, fructose, glucose, glycerin, glycol, 1,2,6-hexanetriol, sodium lactate, sodium PCA, hydrogenated starch hydrolysate, inositol, lactic acid, lactose, mannitol, PCA, PEG-10 propylene glycol, polyamino sugar condensate, propylene glycol, pyridoxine dilaurate, saccharide hydrolysate, hydroxystearyl methylglucamine, glucamine, maltitol, mannitol, methyl gluceth-10, methyl gluceth-20, riboflavin, PEG-4, PEG-6, PEG-8, PEG-9, PEG-10, PEG-12, PEG-14, PEG-16, PEG-18, PEG-20, PEG-32, PEG-40, glutamic acid, glycereth-7, glycereth-12, glycereth-26, saccharide isomerate, sorbeth-20, sorbitol, sucrose, thioglycerin, tris-(hydroxymethyl)nitromethane, tromethamine, histidine, PEG-75, PEG-135, PEG-150, PEG-200, PEG-5 pentaerythritol ether, polyglyceryl sorbitol, sorbitol, urea, xylitol, and mixtures thereof.

[0107] G. Carrier

[0108] The carrier of the composition comprises water.

[0109] H. Optional Ingredients

[0110] An antibacterial composition of the present invention also can contain optional ingredients well known to persons skilled in the art, such as dyes and fragrances, that are present in a sufficient amount to perform their intended function and do not adversely affect the antibacterial efficacy of the composition. Such optional ingredients typically are present, individually, from 0% to about 5%, by weight, of the composition, and, collectively, from 0% to about 20%, by weight, of the composition.

[0111] Classes of optional ingredients include, but are not limited to, dyes, fragrances, pH adjusters, preservatives, thickeners, viscosity modifiers, buffering agents, antioxidants, foam enhancers, chelating agents, opacifiers, and similar classes of optional ingredients known to persons skilled in the art.

[0112] Specific classes of optional ingredients include alkanolamides as foam boosters; parabens as preservatives; inorganic phosphates, sulfates, and carbonates as buffering agents; EDTA and phosphates as chelating agents; and acids and bases as pH adjusters.

[0113] Examples of preferred classes of basic pH adjusters are ammonia; mono-, di-, and tri-alkyl amines; mono-, di-, and tri-alkanolamines; alkali metal and alkaline earth metal hydroxides; and mixtures thereof. However, the identity of the basic pH adjuster is not limited, and any basic pH adjuster known in the art can be used. Specific, nonlimiting examples of basic pH adjusters are ammonia; sodium, potassium, and lithium hydroxide; monoethanolamine; triethylamine; isopropanolamine; diethanolamine; and triethanolamine.

[0114] Examples of preferred classes of acidic pH adjusters are the mineral acids and polycarboxylic acids. Nonlimiting examples of mineral acids are hydrochloric acid, nitric acid, phosphoric acid, and sulfuric acid. Nonlimiting examples of polycarboxylic acids are citric acid, glycolic acid, and lactic acid. The identity of the acidic pH adjuster is not limited and any acidic pH adjuster known in the art, alone or in combination, can be used.

[0115] An alkanolamide to provide foam enhancement can be, but is not limited to, cocamide MEA, cocamide DEA, soyamide DEA, lauramide DEA, oleamide MIPA, stearamide MEA, myristamide MEA, lauramide MEA, capramide DEA, ricinoleamide DEA, myristamide DEA, stearamide DEA, oleylamide DEA, tallowamide DEA, lauramide MIPA, tallowamide MEA, isostearamide DEA, isostearamide MEA, and mixtures thereof.

[0116] A present antibacterial composition also can contain a preservative in an amount of 0% to about 0.5% by weight. Examples of preservatives include, but are not limited to, sorbic acid, potassium sorbate, the parabens (like benzylparaben), imidazolinylurea, methylchloroisothiazolinone, and the hydantoins, like DMDM hydantoin. Additional preservatives as disclosed in the CTFA Handbook at page 78, incorporated herein by reference.

[0117] A present antibacterial composition further can contain an antioxidant and/or an ultra-violet light (UV) absorber, each independently in an amount of 0% to about 0.5% by weight. Examples of antioxidants of UW absorbers include, but are not limited to, BHA, BHT, sodium ascorbate, potassium sulfite, erythorbic acid, benzophenone-1 through benzophenone-12, and PABA. Additional antioxidants and UV absorbers can be found in the CTFA Handbook at pages 78 and 98, incorporated herein by reference.

[0118] In addition, the antibacterial compositions of the present invention do not rely upon a low pH or a high pH to provide a rapid reduction in bacterial populations. Antibacterial compositions of the present invention can have a pH of about 4 to about 9, but at the two extremes of this pH range, the compositions can be irritating to the skin or damaging to other surfaces contacted by the composition. Accordingly, antibacterial compositions of the present invention preferably have a pH of about 5 to about 8, and more preferably about 6 to about 8. To achieve the full advantage of the present invention, the antibacterial compositions have a pH of about 6.5 to about 7.5.

[0119] To demonstrate the new and unexpected results provided by the antibacterial compositions of the present invention, the examples in Appendix A were prepared, and the ability of the compositions to control Gram positive and Gram negative bacteria was determined. The weight percentage listed in each of the examples represents the actual, or active, weight amount of each ingredient present in the composition. The compositions were prepared by blending the ingredients, as understood by those skilled in the art.

[0120] The following materials were used as ingredients in the examples. The source of each ingredient and its abbreviation are summarized below:

[0121]

			Abbre-
Chemical Name	Trade Name	Supplier	viation
Surfactants
Ammonium Lauryl	STANDAPOL A	Cognis	ALS
Sulfate	(28.3% active)	Corporation
		Ambler, PA
Sodium Lauryl	STANDAPOL	Cognis	SLES2
Ether Sulfate	ES-2	Corporation
(2-mole)	(25.71% active)
Ammonium Cocyl	JORDAPON	BASF	ACI
Isethionate	ACI-30G	Corporation
	Isethionate	Mount Olive,
	(25% active)	NJ
Cocamidopropyl-	MACKAM	McIntyre	CAPB
betaine	35-HP (about	Group
	30% active)	Chicago, IL
Hydrotropes
Sodium Xylene	STEPANATE	Stepan	SXS
Sulfonate	SXS	Company
	(40-42% active)	Northfield, IL
Hydric Solvents
Dipropylene	Dipropylene	Ashland	DPG
Glycol	Glycol	Chemical Co.
	(100% active)	Covington, KY
Polymers
Polyvinylpyrrol-	PVP K-15	International	PVPK15
idone	(98-99% active)	Specialty
		Products
		Wayne, NJ
Polyvinylpyrrol-	PVP K-30	International	PVPK30
idone	(98-99% active)	Specialty
		Products
Guar Gum, 2-	JAGUAR C13S	Rhodia	JAGC13S
Hydroxy-3-(Tri-	(88-94% active)	Cranbury, NJ
methylammonio)-
Propyl Ether
Chloride
Guar Gum, 2-Hy-	JAGUAR C14S	Rhodia	JAGC14S
droxy-3-(Tri-	(88-94% active)
methylammonio)-
Propyl Ether
Chloride
Guar Gum, 2-Hy-	JAGUAR C162	Rhodia	JAGC162
droxy-3-(Tri-	(91% active)
methylammonio)-
Propyl Ether
Chloride
Guar Gum, 2-Hy-	JAGUAR HP8	Rhodia	JAGHP8
droxypropyl	(88-94% active)
Ether
Guar Gum, 2-Hy-	JAGUAR HP60	Rhodia	JAGHP60
droxypropyl	(87-94% active)
Ether
Guar Gum, 2-Hy-	JAGUAR HP105	Rhodia	JAGHP105
droxypropyl	(90-97% active)
Ether
Guar Gum, 2-Hy-	JAGUAR HP120	Rhodia	JAGHP120
droxypropyl	(91-95% active)
Ether
Polyquaternium-7	MERQUAT 550	Calgon	MQ550
	(9% active)	Corporation
		Pittsburgh, PA
Polyquaternium-4	CELQUAT	National Starch	CQSC230M
	SC-230M	& Chemical
	(100% active)	Bridgewater,
		NJ
Polyquaternium-	CELQUAT	National Starch	CQSC240C
10	SC-240C	& Chemical
	(100% active)
Polyquaternium-4	CELQUAT	National Starch	CQH100
	H-100	& Chemical
	(100% active)
Hydroxypropyl-	METHOCEL	Dow Chemical	MCL40100
methylcellulose	40-100	Co.
	(90-95% active)	Midland, MI
Hydroxyethyl-	NATROSOL 250	Aqualon/	NATSOL250
cellulose	HHR	Hercules	HHR
	(95-100% active)	Wilmington,
		DE
PEG-6 & PEG-32	CARBOWAX	Dow Chemical	CWAX540
	Sentry	Co.
	Polyethylene	Midland, MI
	Glycol 540
	(100% active)
PEG-18	CARBOWAX	Dow Chemical	CWAX900
	Sentry	Co.
	Polyethylene
	Glycol 900
	(100% active)
MethoxyPEG-1000	CARBOWAX	Dow Chemical	MET5000
	Methoxypolyeth-	Co.
	ylene glycol
	5000
	(100% active)
MethoxyPEG-40	CARBOWAX	Dow Chemical	MET2000
	Methoxypolyeth-	Co.
	yleneglycol
	2000
	(100% active)
PEG-100	CARBOWAX	Dow Chemical	PG4600
	Polyethylene-	Co.
	glycol 4600
	(100% active)
PEG-6ME	PEG6ME	Dow Chemical	PEG6ME
	(100% active)	Co.
PEG-45M	POLYOX	Amerchol	WSRN60
	WSR-N-60	Institute, WV
	(100% active)
PEG-14M	POLYOX	Amerchol	WSR205
	WSR-205
	(100% active)
PEG-14M	POLYOX	Amerchol	WSR-N-
	WSR-N-3000		3000
	(99% active)
Poly(sodium	FLEXAN 130	National Starch	FLEX130
styrene	(30% active)	& Chemical
sulfonate)
Protein
Derivatives
Wheatgermamido-	MACKPRO	McIntyre	WWP
propyl Hydroxy-	WWP	Group
propyl Dimonium	(35% active)
Hydrolyzed Wheat
Protein
Quaternium-79	MACKPRO	McIntyre	NLW
Hydrolyzed Wheat	NLW	Group
Protein	(33% active)
Silicone
Derivatives
Dimethicone	ABIL B 9950	Goldschmidt	DIMETHPGB
Propyl PG	(29-31% active)	Hopewell, VA
Betaine
Stearyl	SILCARE 41M30	Clariant	STMETH
Methicone	(88% active)	Gainesville, FL
Dimethicone	Dow Corning 193	Dow Corning	DC193
Copolyol	(100% active)	Auburn, MI
Humectants
Glycerine	Glycerin, USP	Cognis/Emery	GLY
	(100% active)	Cincinnati, OH
Sodium PCA	AJIDEW NL-50	Ajinomoto	NaPCA
	(50% active)	Teaneck, NJ
Steareth-2	Polyoxyethyl-	ICI Americas	BRIJ72
	ene-(2) stearyl	Bridgewater,
	ether (BRIJ 72)	NJ
	(99% active)
Steareth-21	Polyoxyethyl-	ICI Americas	BRIJ721
	ene-(21) stear-
	yl ether (BRIJ
	721)
	(99% active)
Isoceteth-20	ARLASOLVE	ICI Americas	ARL200
	200
	(73% active)
PEG-7 Glyceryl	CETIOL HE	Cognis	PEG7GC
Cocoate	(100% active)	Corporation
PEG-75 Lanolin	FANCOR LAN	Fanning	PEG75LAN
	AQUA 501	Corporation
	(100% active)	Chicago, IL
Sorbitan Oleate	ARLACEL 80	ICI Americas	ARL80
	(100% active)
Cocoglucoside	LAMESOFT	Cognis	LMSFT
and Glyceryl	PO-65	Corporation
Oleate	(65% active)
Glycereth-26	JEECHEM	Jeen Inter-
	GL-26	national Corp.
	(100% active)	Little Falls,
		NJ
PPG-5-Ceteth-20	PROCETYL	Croda	PPG5CET20
	AWS	Parsippany, NJ
	(100% active)
Long-chain Fatty
Materials
Cetyl alcohol	Cetyl alcohol	Aldrich	CETOH
	(100% active)	Milwaukee, WI
Cetearyl alcohol	STENOL 1618	Cognis	CETEAROH
	(100% active)	Corporation
Stearic Acid	Stearic Acid	Aldrich	StAC
	(100% active)
Isopropyl	KESSCO IPM	Stepan	IPM
Myristate	(100% active)	Company
Decyl Oleate	CETIOL V	Cognis	DCYLOL
	(100% active)	Corporation
Cetearyl	CETIOL SN	Cognis	CETISONON
Isononanate	(100% active)	Corporation
Lipid-like
Materials
Canola Oil	Canola Oil	Procter &	CANOL
	(100% active)	Gamble
		Cincinnati, OH
Glyceryl Laurate	LAURICIDIN	Med-Chem	LRCDN
	(100% active)	Labs, Inc.
		Galena, IL
Triglyceryl			TGMS
Monostearate
Glyceryl	EMEREST 2400	Cognis	GMS
Monostearate	(100% active)	Corporation
Other Materials
Mackalene 1216	MACKERNIUM	McIntyre	MAC1216
	1216	Group
	(24% active)
Sunflower seed	MACKERNIUM	McIntyre	SFES
amidopropyleth-	SFES	Group
yldimonium	(80% active)
ethylsulfate
Sodium PEG-7	OLIVEM 400	B&T	OL400
Olive Oil	(35% active)	Milano, IT
Carboxylate
Vitamin E	Vitamin E	Roche	VitEAc
Acetate	Acetate	Nutley, NJ
	(100% active)
PPG-1	PROMIDIUM	Uniquema	PCC
Hydroxyethyl	CC	Paterson, NJ
Caprylamide	(100% active)
PPG-2	PROMIDIUM	Uniquema	PCO
Hydroxyethyl	CO
Cocamide	(100% active)
Mineral Oil	Mineral Oil	Mallinckradt	MO
	(100% active)	Hazelwood,
		MO
Petrolatum			PETR
Aloe Barbadensis	ACTIVERA 104	Active	ALOE
Leaf Juice	(≦1% active)	Organics
		Lewisville, TX
Isostearamido-	MACKALENE	McIntyre	ISML
propylmorpholine	426	Group
Lactate	(25% active)
Strontium	Sr(OAc)2	Aldrich	Sr(OAc)2
Acetate	(100% active)
Palmitamido-	VARISOFT	Goldschmidt	VRSFT
propyltrimonium	PATC
Chloride	(57-61% active)
Antimicrobial
Agent
Triclosan	IRGASAN	Ciba Specialty	TCS
	DP-300	Chemicals
	(100% active)	Corp.
		Greensboro,
		NC

[0122] The following methods were used in the preparation and testing of the examples:

[0123] a) Determination of Rapid Germicidal (Time Kill) Activity of Antibacterial Products. The activity of antibacterial compositions was measured by the time-kill method, whereby the survival of challenged organisms exposed to an antibacterial test composition is determined as a function of time. In this test, a diluted aliquot of the composition is brought into contact with a known population of test bacteria for a specified time period at a specified temperature. The test composition is neutralized at the end of the time period, which arrests the antibacterial activity of the composition. The percent or, alternatively, log reduction from the original bacterial population is calculated. In general, the time kill method is known to those skilled in the art.

[0124] The composition can be tested at any concentration from 0-100%. The choice of which concentration to use is at the discretion of the investigator, and suitable concentrations are readily determined by those skilled in the art. For example, viscous samples usually are tested at 50% dilution, whereas nonviscous samples are not diluted. The test sample is placed in a sterile 250 mL beaker equipped with a magnetic stirring bar, and the sample volume is brought to 100 mL, if needed, with sterile, deionized water. All testing is performed in triplicate, the results are combined, and the average log reduction is reported.

[0125] The choice of contact time period also is at the discretion of the investigator. Any contact time period can be chosen. Typical contact times range from 15 seconds to 5 minutes, with 30 seconds and 1 minute being typical contact times. The contact temperature also can be any temperature, typically room temperature, or about 25 degrees Celsius.

[0126] The bacterial suspension, or test inoculum, is prepared by growing a bacterial culture on any appropriate solid media (e.g., agar). The bacterial population then is washed from the agar with sterile physiological saline, and the population of the bacterial suspension is adjusted to about 108 colony forming units per mL (cfu/mL).

[0127] The table below lists the test bacterial cultures used in the following tests and includes the name of the bacteria, the ATCC (American Type Culture Collection) identification number, and the abbreviation of the name of the organism used hereafter.

[0128]

	Organism Name	ATCC #	Abbreviation
	Staphylococcus aureus	6538	Sa
	Escherichia coli	11229	Ec
	Serratia marcescens	14756	Sm
	Klebsiella pneumoniae	10031	Kp

[0129] Staphylococcus aureus is a Gram positive bacteria, whereas Escherichia coli and Serratia marcescens are Gram negative bacteria. Many formulations were screened for antibacterial efficacy using Serratia marcescens because Sm is relatively difficult to kill rapidly and is used as a test organism in the “Health Care Personnel Hand wash Test” described in “21 CFR Parts 333 and 369 Tentative Final Monograph for Heath Care Antiseptic Drug Products; Proposed Rule” (Food and Drug Administration, Federal Register, Vol. 59, No. 116, Friday, Jun. 17, 1994 Proposed Rules).

[0130] The beaker containing the test composition is placed in a water bath (if constant temperature is desired), or placed on a magnetic stirrer (if ambient laboratory temperature is desired). The sample then is inoculated with 1.0 mL of the test bacterial suspension. The inoculum is stirred with the test composition for the predetermined contact time. When the contact time expires, 1.0 mL of the test composition/bacteria mixture is transferred into 9.0 mL of Tryptone-Histidine-Tween Neutralizer Solution (THT). Decimal dilutions to a countable range then are made. The dilutions can differ for different organisms. Selected dilutions are plated in triplicate on TSA+ plates (TSA+ if Trypitcase Soy Agar with Lecithin and Polysorbate 80). The plates then are incubated for 25±2 hours, and the colonies are counted for the number of survivors, and the percent or log reduction is calculated. The control count (numbers control) is determined by conducting the procedure as described above with the exception that THT is used in place of the test composition. The plate counts are converted to cfu/mL for the numbers control and samples, respectively, by standard microbiological methods. The log reduction is calculated using the formula
Log reduction=Log₁₀(numbers control)−log₁₀(test sample survivors).

[0131] The following table correlates percent reduction in bacterial population to log reduction.

[0132]

	% Reduction	Log Reduction
	90	1
	99	2
	99.9	3
	99.99	4
	99.999	5

[0133] b) Physical Stability Screening. The stability of test compositions was determined by observing the compositions several days after preparation to determine whether phase separation occurred. This screening test was used to determine whether the test composition would be tested further.

[0134] c) Foam Property Screening. The foam properties and end use performance enhancement of the compositions was determined by the following two methods:

[0135] 1) Bottle Shake Foam Test. This test was performed by inverting bottles containing test compositions and timing the persistence of the foam head. In a typical test, eight to ten compositions (each contained in a capped, 1L, French square bottle) are tested as a set. Each set includes a control which has the same base formula as the others, but does not contain any performance-enhancing additives. The set of samples first is allowed to equilibrate at a common temperature (usually about 25° C.). The bottles then are arranged in a row and inverted five times each, all within about 1 minute. The bottles then are allowed to stand for about 1 to 3 hours, and the time of foam collapse (as judged by an opening in the foam head equal to about 2.5 cm) is recorded. The foam collapse times are compared to the control and summarized as shown in the table below:

[0136]

Foam Rating
(Bottle or Pump Test)	Description
+ + +	Bottle Foam stable for several days
+ +	Foam persisted longer than the test
	time
+	Foam persisted longer than control
	sample, but less than total test time
0	Foam collapsed at the same time as
	control
−	Foam collapsed sooner than control
− −	Foam collapsed almost immediately
NT	Not tested

[0137] 2) Pump Foam Test. Because a preferred route of application is use of a self-foaming pump, this test assesses stability of test sample foam ejected from this type of pump. The self-foaming pump used in this test is manufactured by Air-spray International B.V., Alkmaar, Holland (model Airspray 1.65 ml TT Pump with EVA(PIB) liner). This test was performed by ejecting one pump stroke of foam on a precleaned watch glass (100 mm, Corning Glass Works, #9985) and observing the time of foam collapse. In a typical test, 8 to 10 samples (each contained in a plastic bottle equipped with a foaming pump) are tested as a set. As in the Bottle Foam Test, each set includes a control which has the same base formula as the others, but does not contain any performance-enhancing additives. The set of samples first is allowed to equilibrate at a common temperature (usually about 25° C.). The pumps/bottles and corresponding watch glasses are arranged in two parallel rows. The pumps are primed with three strokes just prior to the test. One pump-stroke of foam is ejected onto the corresponding watch glass of each sample, all within about 1 minute. The foam samples then are allowed to stand for about 1 to 3 hours, and the time of foam collapse (as judged by circle of bubbles about 5 mm or less) is recorded. The foam collapse times are compared to the control and summarized as shown in the table above.

[0138] d) Preparation of Samples. The preparation of all samples involved equipment and procedures normally employed in formula development laboratories. All percents were by weight based on the active level of each ingredient.

[0139] e) Summary formula descriptions in example tables. A typical table entry for a test composition is “0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/0.2-PVPKS15.” This entry is defined as 0.6% triclosan (TCS), 5% dipropylene glycol (DPG), 15% sodium xylene sulfonate (SXS), 1.5% ammonium lauryl sulfate (ALS), 0.5% cocamidopropyl betaine (CAPB), 0.2% polyvinylpyrrolidone polymer (PVP K-15), and the remainder of the formula is water (typically with 0.2%, by total weight, of a citrate/phosphate buffer designed to provide a pH of about 6).

[0140] f) Preparation of saturated solutions of TCS in water. A four-liter flask was equipped with a 3-inch magnetic stir bar and charged with approximately 7.5 grams (g) TCS and 3 liters (L) of water. The flask then was placed in a water bath, stirred, and heated (40-45° C.) for at least 8 hours. The flask containing the resulting TCS/water suspension was removed from the water bath, and the warm suspension filtered through a Coors #32-H porcelain Buchner funnel equipped with Whatman #40 (5.5 cm) filter paper. The filtering assembly was attached to a two-liter vacuum filter flask, and filtration was conducted in batches. The filtrate then was transferred to another four-liter flask and allowed to cool. Typically, fine needles of TCS crystals formed after the filtrate was stored at room temperature for a few days.

[0141] For some time-kill studies, the TCS solution was refiltered at room temperature before use in the study. For other time-kill studies, a small amount of crystalline TCS was allowed to remain in the test container to ensure saturation in the event of a temperature change. It was assumed that TCS crystals present in the time-kill test vessel would not affect test results because crystalline TCS is unavailable to act on the bacteria (i.e., is not solubilized).

[0142] To determine the concentration of TCS in the water solutions, filtered samples (in triplicate) were analyzed by HPLC. The apparatus used to filter the solutions was a Whatman AUTOVIAL®, with 0.45 μm PTFE membrane and glass microfiber prefilter, cat. No. AV125UORG. TCS concentrations were calculated using a linear regression line fit (Microsoft EXCEL® software) to TCS/IPA standards included on the same HPLC run.

[0143] The following examples demonstrate that the new and unexpected results achieved by the present invention are attributed (in part) to a selection of esthetic enhancing and skin care additives which maintain a phase-stable system, do not hinder antibacterial activity, and contribute to composition performance and esthetics.

[0144] Phase stability and foam performance attributed to polyvinylpyrrolidone (PVP) polymer additives—The compositions in this example demonstrate the phase stability and performance observed during testing of compositions containing PVP polymer additives. In this test, PVP K-15 failed to improve foam properties in the base formula evaluated, whereas PVP K-30 exhibited foam property improvement at higher surfactant levels.

[0145]

			Stable
			(S)/Not	Bottle	Pump
			Stable	Foam	Foam
Polymers	Comment	Formula	(NS)	Test	Test
PVPK15	MW =	0.6TCS/5DPG/15SXS/	S	—	—
	8,000	1.5ALS/0.5CAPB/
		0.2PVPK15
PVPK30	MW =	0.3TCS/5DPG/15SXS/	NS	NT	NT
	38,000	0.75ALS/0.05PVPK30
PVPK30	MW =	0.3TCS/5DPG/15SXS/	NS	NT	NT
	38,000	0.75ALS/0.02PVPK30
PVPK30	MW =	1.0TCS/5DPG/15SXS/	S	++	++
	38,000	2.5ALS/0.75CAPB/
		0.1PVPK30

[0146] Phase stability and foam performance attributed to modified guar polymer additives—The compositions in this example demonstrate the phase stability observed during testing of compositions containing modified guar polymer additives. The nonionic 2-hydroxypropyl ether guar gum polymers were successfully incorporated into the compositions. However, two moderately charged cationic polymers (JAGUAR C13S and C14S) were not stable in the base formula. JAGUAR C162, a similar polymer having less charge density, was effectively incorporated into compositions of the present invention. JAGUAR HP-60-containing compositions exhibited excellent slip properties for dry application, when the polymer is present in a sufficient amount to provide a perceivable esthetic improvement, but not an amount such that the composition is too slippery and too thick for use with a self-foaming pump.

[0147]

			Stable (S)/
			Not Stable	Bottle Foam	Pump Foam
Polymers	Comment	Formula	(NS)	Test	Test
JAGUAR HP-8	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
	2-Hydroxypropyl	0. 05HP8
	Ether
JAGUAR HP-60	Guar Gum,	1.0TCS/5DPG/15SXS/2.5ALS/	S	0	+
	2-Hydroxypropyl	0.75CAPB/0.2HP60
	Ether
JAGUAR HP-60	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
	2-Hydroxypropyl	0.2HP60
	Ether
JAGUAR HP-60	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
	2-Hydroxypropyl	0.1HP60
	Ether
JAGUAR HP-60	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
	2-Hydroxypropyl	0.1HP60
	Ether
JAGUAR HP-60	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
	2-Hydroxypropyl	0.05HP60
	Ether
JAGUAR HP-60	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	−
	2-Hydroxypropyl	0.075HP60
	Ether
JAGUAR HP-105	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
	2-Hydroxypropyl	0.05HP105
	Ether
JAGUAR HP-120	Guar Gum,	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
	2-Hydroxypropyl	0.05HP120
	Ether
JAGUAR C13S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.5JAGC13S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C13S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.05JAGC13S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C13S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.2JAGC13S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C14S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.5JAGC14S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C14S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.05JAGC14S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C14S	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	NS	NT	NT
	Hydroxy-3-(tri-	0.2JAGC14S
	methylammonio)-
	propyl ether
	chloride
JAGUAR C162	Guar Gum, 2-	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
	Hydroxy-3-(tri-	0.05C162
	methylammonio)-
	propyl ether
	chloride

[0148] Phase stability and foam performance attributed to a cationic copolymer containing 50% dimethyl diallyl ammonium chloride (DMAAC) and 50% acrylamide additive—The compositions in this example demonstrate the phase stability observed by incorporating a highly charged polymer into the composition. It was found that a relatively high surfactant level was required to successfully incorporate a highly charged polymer into the composition, even at a 0.05% polymer. As described in U.S. Pat. No. 6,107,261, the highest antimicrobial activity is obtained for compositions having a high % saturation of antimicrobial agent. Thus, raising the surfactant level to accommodate solubilization of the polymer or other additives, requires a higher level of antibacterial agent in the composition to maintain a high % saturation. For example, in the first composition of this example, 1.0% TCS was required to maintain the desired % saturation vs. 0.3% in compositions containing a lower amount of surfactant.

[0149]

			Stable (S)/
			Not Stable	Bottle Foam	Pump Foam
Polymers	Comment	Formula	(NS)	Test	Test
MERQUAT 550	MW = 1,600,000/-	1.0TCS/5DPG/15SXS/	S	++	+
	highly charged	2.5ALS/0.75CAPB/0.2MQ550
	cationic copolymer
MERQUAT 550	MW = 1,600,000/-	0.3TCS/5DPG/15SXS/0.75	NS	NT	NT
	highly charged	ALS/0.05MQ550
	cationic copolymer
MERQUAT 550	MW = 1,600,000/-	0.3TCS/5DPG/15SXS/0.75	NS	NT	NT
	highly charged	ALS/0.05MQ550
	cationic copolymer
MERQUAT 550	MW = 1,600,000/-	0.3TCS/5DPG/15SXS/0.75	NS	NT	NT
	highly charged	ALS/0.05MQ550
	cationic copolymer

[0150] Phase stability and foam performance attributed to cationic hydroxyethylcellulose polymer additives—CELQUAT SC-230M and SC-240C each have a hydroxyethylcellulose (HEC) backbone further derivatized with 2-hydroxy(trimethylammonio)propyl ether to provide a cationic polymer. The average molecular weight of the HEC backbone of SC-240C is about 63% that of SC-230M. The performance of these two polymers is similar except SC-230M produced a higher composition viscosity at a lower weight % level. Thus, SC-240C is preferred polymer for use with a foaming pump because of a lower viscosity, which is attributed to, but not relied upon, a lower molecular weight of this polymer compared to SC-230M.

[0151] CELQUAT H-100 has an HEC backbone which is derivatized with polyDMDAC, and has a high localized nitrogen charge density. In the present compositions, CELQUAT H-100 provides excellent foam stability, skin feel, and skin care properties.

[0152]

			Stable (S)/
			Not Stable	Bottle	Pump Foam
Polymers	Comment	Formula	(NS)	Foam Test	Test
CELQUAT	MW = 1,750,000	1.0TCS/5DPG/15SXS/2.5ALS/	S	++	+
SC-230M		0.75CAPB/0.1CQSC230M
CELQUAT	MW = 1,750,000	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
SC-230M		0.1CQSC230M
CELQUAT	MW = 1,750,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	+	−
SC-230M		0.5CAPB/0.3CQSC230M
CELQUAT	MW = 1,750,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	+	+
SC-230M		0.5CAPB/5GLY/0.5CQSC230M
CELQUAT	MW = 1,750,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	−	++
SC-230M		0.75CAPB/0.5CQSC230M
CELQUAT	MW = 1,750,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	+	+
SC-230M		0.5CAPB/5GLY/0.5CQSC230M
CELQUAT	MW = 1,100,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	+	−
SC-240C		0.5CAPB/0.5CQSC240C
CELQUAT	MW = 1,100,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	+	+
SC-240C		0.5CAPB/1.0CQSC240C
CELQUAT	MW = 1,400,000	0.6TCS/5DPG/15SXS/1.5ALS/	S	++	++
H-100		0.75CAPB/0.5CQH100

[0153] Phase stability and foam performance attributed to hydroxypropylcellulose (HPC) and hydroxyethylcellulose (HEC) polymer additives—Compositions containing the HPC polymer exhibited acceptable foam properties, but marginal phase instability, at lower surfactant levels. The composition containing the HEC polymer was phase stable, but foam properties were not improved.

[0154]

			Stable (S)/
			Not Stable	Bottle	Pump Foam
Polymers	Comment	Formula	(NS)	Foam Test	Test
METHOCEL	Hydroxypropyl-	0.3TCS/5DPG/15SXS/	S	+	+
40-100	cellulose	0.75ALS/0.1MCL40100	(turbid)
METHOCEL	Hydroxypropyl-	0.3TCS/5DPG/15SXS/	NS	NT	NT
40-100	cellulose	0.75ALS/0.2MCL40100
METHOCEL	Hydroxypropyl-	0.3TCS/5DPG/15SXS/	S	+	+
40-100	cellulose	0.75ALS/0.05MCL40100	(turbid)
METHOCEL	Hydroxypropyl-	1.0TCS/5DPG/15SXS/	S	++	+
40-100	cellulose	2.5ALS/0.75CAPB/
		0.2MCL40100
NATROSOL	Hydroxyethylcellulose	0.3TCS/5DPG/15SXS/	S	−	−
250 HHR		0.75ALS/
		0.05NATSOL250HHR

[0155] Phase stability and foam performance attributed to polyethylene glycol (PEG) and methoxypolyethylene glycol (MPEG) polymer additives—The compositions in this example illustrate the effect of increasing polymer chain length on phase stability, i.e., longer polymer chains decrease composition stability. In addition, while shorter chain polymers provided a stable base formula, foam performance was best for the shortest chain polymer (PEG6ME).

[0156]

			Stable (S)/
			Not Stable	Bottle	Pump Foam
Polymers	Comment	Formula	(NS)	Foam Test	Test
PEG6ME	MW = 335 to 365	0.6TCS/5DPG/15SXS/1.5	S	++	−
		ALS/0.5CAPB/1PEG6-ME
CARBOWAX 540	MW = 468 to 534	0.6TCS/5DPG/15SXS/	S	−	−
(PEG-6 & PEG-32)		1.5ALS/0.5CAPB/1.0CWA
		X540
CARBOWAX 900	MW = 855 to 945	0.6TCS/5DPG/15SXS/	S	−	−
(PEG-18)		1.5ALS/0.5CAPB/1.0CWA
		X900
Methoxypolyeth-	MW = 1800 to 2200	0.6TCS/5DPG/15SXS/	S	−	−
ylene glycol 2000		1.5ALS/0.5CAPB/0.5MET
(Methoxy PEG-40)		2000
Polyethylene glycol	MW = 4140 to 5060	0.6TCS/5DPG/15SXS/	S	−	−
4600 (PEG-100)		1.5ALS/0.5CAPB/0.5PG4
		600
Methoxypolyeth-	MW = 4375 to 5675	0.6TCS/5DPG/15SXS/	S	−	−
ylene glycol 5000		1.5ALS/0.5CAPB/0.5MET
(Methoxy PEG 1000)		5000
POLYOX WSR-N-3000	MW = 400,000	0.6TCS/5DPG/15SXS/	S	NT	NT
		1.5ALS/0.5CAPB/1WSR-	(slightly
		N-3000	turbid)
POLYOX WSR-205	MW = 600,000	0.6TCS/5DPG/15SXS/	S	NT	NT
		1.5ALS/0.5CAPB/0.5WSR	(turbid)
		205
POLYOX WSR-N-60	MW = 2,000,000	0.6TCS/5DPG/15SXS/	NS	NT	NT
		1.5ALS/0.5CAPB/0.05WS
		RN60

[0157] Phase stability and foam performance attributed to a poly(sodium styrene sulfonate) polymer additive—This example illustrates the performance of an anionic polymer additive. This polymer provided a stable composition, but marginal lather performance.

[0158]

			Stable (S)/	Bottle Foam
Polymers	Comment	Formula	Not Stable (NS)	Test	Pump Foam Test
FLEXAN 130		0.6TCS/5DPG/15SXS/1.5ALS/	S	−	−
		0.5CAPB/1.0FLEX130

[0159] Phase stability and foam performance attributed to protein derivative additives—A majority of the compositions evaluated in this example were phase stable and exhibited moderate foam property enhancement. NLW was solubilized more easily by the base composition than WWP.

[0160]

			Stable (S)/
Protein			Not Stable	Bottle	Pump Foam
Derivative	Comment	Formula	(NS)	Foam Test	Test
MACKPRO WWP	Wheatgermamidopropyl	0.3TCS/5DPG/15SXS/	S	−	+
	Hydroxypropyl Dimonium	0.75ALS/0.1WWP
	Hydrolyzed Wheat Protein
MACKPRO WWP	Wheatgermamidopropyl	1.0TCS/5DPG/15SXS/	NS	NT	NT
	Hydroxypropyl Dimonium	2.5ALS/0.75CAPB/0.2WWP
	Hydrolyzed Wheat Protein
MACKPRO WWP	Wheatgermamidopropyl	0.3TCS/5DPG/15SXS/	S	+	+
	Hydroxypropyl Dimonium	0.75ALS/1.0WWP
	Hydrolyzed Wheat Protein
MACKPRO WWP	Wheatgermamidopropyl	0.3TCS/5DPG/15SXS/	S	+	+
	Hydroxypropyl Dimonium	0.75ALS/0.5WWP
	Hydrolyzed Wheat Protein
MACKPRO NLW	Quaternium-79 Hydrolyzed	0.3TCS/5DPG/15SXS/	S	+	−
	Wheat Protein	0.75ALS/0.2NLW
MACKPRO NLW	Quaternium-79 Hydrolyzed	1.0TCS/5DPG/15SXS/	S	0	+
	Wheat Protein	2.5ALS/0.75CAPB/0.1NLW
MACKPRO NLW	Quaternium-79 Hydrolyzed	1.0TCS/5DPG/15SXS/	S	+	+
	Wheat Protein	2.5ALS/0.75CAPB/0.2NLW

[0161] Phase stability and foam performance attributed to humectant additives—Two humectants, glycerin and sodium pyrrolidone carboxylate (sodium PCA), were evaluated. This example shows that phase stability is not adversely affected by these humectants, and that the amount of humectant can be adjusted for optimum foam properties.

[0162]

			Stable (S)/	Bottle	Pump
	Com-		Not Stable	Foam	Foam
Humectant	ment	Formula	(NS)	Test	Test
Glycerin		1.0TCS/5DPG/15SXS/	S	−	+
		2.5ALS/0.75CAPB/
		5GLY
Glycerin		0.6TCS/5DPG/15SXS/	S	−	−
		1.5ALS/0.75CAPB/
		10GLY
Glycerin		0.3TCS/2DPG/15SXS/	S	−	−
		0.75ALS/20GLY
Sodium PCA		0.3TCS/2DPG/15SXS/	S	−	−
		0.75ALS/1.0PCA
Sodium PCA		0.3TCS/5DPG/15SXS/	S	+	+
		0.75ALS/0.5PCA

[0163] Phase stability and foam performance attributed to ethoxylated additives—Ethoxylated additives provide an advantage because of a wide variety of raw materials and the ability to predetermine properties by a judicious selection of the level of ethoxylation of the additive. It was observed that ethoxylated compounds having a relatively low level of ethoxylation (e.g., additives having an HLB about 4 to 8) were difficult to solubilize in the compositions, but gave excellent foam properties. Ethoxylated compounds having a higher level of ethoxylation (e.g., HLB about 8 to 17) were more easily solubilized, and also exhibited good to excellent foam properties. A mixture of ethoxylate compounds having an HLB about 12 also exhibited excellent foam properties demonstrated by the “+++” bottle foam test result.

[0164]

			Stable (S)/
			Not Stable	Bottle	Pump Foam
Ethoxylated Additive	Comment	Formula	(NS)	Foam Test	Test
Polyoxyethylene	HLB = 4.9	0.6TCS/5DPG/15SXS/1.5ALS/	S	+++	++
(2) stearyl ether		0.4BRIJ72
(BRIJ 72)
Polyoxyethylene	HLB = 4.9	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
(2) stearyl ether		0.6BRIJ72
(BRIJ 72)
Polyoxyethylene	HLB = 4.9	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
(2) stearyl ether		0.8BRIJ72
(BRIJ 72)
Polyoxyethylene	HLB = 4.9	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
(2) stearyl ether		1.0BRIJ72
(BRIJ 72)
Polyoxyethylene	HLB = 15.5	0.6TCS/5DPG/15SXS/1.5ALS/	S	++	+
(21) stearyl ether		1.0BRIJ721
(BRIJ 721)
BRIJ72/BRIJ721	Est. HLB =	0.6TCS/5DPG/15SXS/1.5ALS/	S	+++	++
	12.5	0.75CAPB/0.4BRIJ72/1.0BRIJ721
ARLASOLVE 200	HLB = 15.7	0.6TCS/5DPG/15SXS/1.5ALS/	S	++	++
		0.75CAPB/1.0ARL200
PEG7 Glyceryl		1.0TCS/5DPG/15SXS/2.5ALS/	S	−	+
Cocoate		0.75CAPB/0.2PEG7GC
PEG7 Glyceryl		0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
Cocoate		0.2PEG7GC
PEG7 Glyceryl		0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
Cocoate		0.5PEG7GC
JEECHEM GL-26		0.3TCS/5DPG/15SXS/0.75ALS/	S	0	0
		0.2JCHMGL26
ARLACEL 80	HLB = 4.3	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
		0.75CAPB/1.0ARL80
ARLACEL 80	HLB = 4.3	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
		0.75CAPB/0.5ARL80
ARLACEL 80	HLB = 4.3	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
		0.75CAPB/0.3ARL80
ARLACEL 80	HLB = 4.3	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
		0.75CAPB/0.1ARL80
LAMESOFT		0.3TCS/5DPG/15SXS/0.75ALS/	S	−	−
		0.1LMSFT

[0165] Phase stability and foam performance attributed to long-chain fatty materials—The compositions of Example 5 show that cetyl alcohol gave outstanding performance in stabilizing foam. In some cases, foam generated in the bottle test lasted several days (vs. under an hour for the control). The amount of cetyl alcohol incorporated into the base formula was 0.05% to 0.5%, by weight. Stearic acid provided improvement in foam properties, and was more difficult to solubilize. The fatty esters generally were more difficult to solubilize in the compositions.

[0166]

			Stable (S)/
Long-chain			Not Stable	Bottle	Pump Foam
Fatty Material	Comment	Formula	(NS)	Foam Test	Test
Cetyl alcohol	0.6TCS/5DPG/15SXS/	S	+	+
	1.5ALS/0.5CAPB/0.05CETOH
Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/	S	++	++
	0.5CAPB/0.2CETOH
Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/	S	++	++
	0.5CAPB/0.2CETOH
Cetyl alcohol	1.0TCS/5DPG/15SXS/2.5ALS/	S	++	++
	0.75CAPB/0.5CETOH
Cetyl alcohol	0.3TCS/5DPG/0.75ALS/	S	++	++
	0.1CETOH
Cetyl alcohol	1.0TCS/5DPG/15SXS/2.5ALS/	S	+++	++
	0.75CAPB/0.3CETOH
Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/	S	−	+
	0.5CAPB/0.05CETOH
Stearic Acid	1.0TCS/5DPG/15SXS/2.5ALS/	S	+	+
	0.75CAPB/0.15STAC
Stearic Acid	1.0TCS/5DPG/15SXS/2.5ALS	NS	NT	NT
	0.75CAPB/0.2STAC
Stearic Acid	0.6TCS/5DPG/15SXS/1.5ALS	S	−	+
	0.75CAPB/0.2STAC
Isopropyl	1.0TCS/5DPG/15SXS/2.5ALS/	NS	NT	NT
Myristate	0.75CAPB/0.2IPM
Decyl Oleate	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
	0.75CAPB/1.0DCYLOL
Decyl Oleate	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
	0.75CAPB/0.5DCYLOL
Decyl Oleate	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
	0.75CAPB/1.0DCYLOL
Cetearyl	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
Isononanate	0.75CAPB/1.0CETISONON
Cetearyl	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
Isononanate	0.75CAPB/0.5CETISONON
Cetearyl	0.6TCS/5DPG/15SXS/1.5ALS/	NS	NT	NT
Isononanate	0.75CAPB/0.25CETISONON

[0167] Phase stability and foam performance attributed to other additives—ISML (isostearylmorpholine lactate) was a useful additive in these tests. Petrolatum was difficult to solubilize in the base formulae of the invention. Petrolatum also is a component of at least two recently introduced commercial antimicrobial hand wash products (see Table 2 below). Commercial product E also contains dimethicone.

[0168]

			Stable (S)/	Bottle	Pump
Other			Not Stable	Foam	Foam
Additives	Comment	Formula	(NS)	Test	Test
MACKERNIUM	0.3TCS/5DPG/15SXS/0.75ALS/0.1MAC1216	S	−	+
1216
MACKERNIUM	0.3TCS/5DPG/15SXS/0.75ALS/0.5SFES	S	−	+
SFES
OLIVEM 400	0.3TCS/5DPG/15SXS/0.75ALS/0.5OL400	S	−	+
PROMIDIUM CC	0.6TCS/5DPG/15SXS/1.5ALS/1PCC	S	−	0
PROMIDIUM CO	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/0.4PCO	S	NT	NT
Mineral Oil	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/0.5MO	NS	NT	NT
Mineral Oil	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/0.25MO	NS	NT	NT
Mineral Oil	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/0.13MO	NS	NT	NT
Mineral Oil	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/0.05MO	NS	NT	NT
Mineral Oil	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
	0.025MO
Petrolatum	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	NS	NT	NT
	0.05PETR
Petrolatum	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/0.1PETR	NS	NT	NT
ISML	0.3TCS/5DPG/15SXS/0.75ALS/0.1ISML	S	+	+
ISML	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/	S	−	+
	0.21ISML
Sr (OAc)2	1.0TCS/5DPG/15SX5/2.5ALS/0.75CAPB/	NS	NT	NT
	0.2Sr (OAc)2
Sr (OAc) 2	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/	NS	NT	NT
	0.2Sr (OAc)2

[0169]

TABLE 2
Ingredients Statements for Commerical Antimicrobial Hand Washer
	Commercial Product E	Commercial Product F
	(ingredients statement on label))	(ingredients statement on labels)
	ACTIVE INGREDIENT: Triclosan	ACTIVE INGREDIENT: 0.25% TRICLOSAN
	OTHER INGREDIENTS:	INACTIVE INGREDIENTS:
	WATER	WATER
	SODIUM LAURETH SULFATE	PETROLATUM
	COCAMIDOPROPYL BETAINE	SODIUM LAUROYL SARCOSINATE
	PETROLATUM	SODIUM LAUROAMPHOACETATE
	DIMETHICONE	AMMONIUM LAURYL SULFATE
	LAURIC ACID	AMMONIUM LAURETH SULFATE
	DECYL GLUCOSIDE	LAURIC ACID
	ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER	TRIHYDROXYSTEARIN
	HYDROXYPROPYL METHYLCELLULOSE	GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE
	TRIETHANOLAMINE	CITRIC ACID
	FRAGRANCE	SODIUM BENZOATE
	DMDM HYDANTOIN	DISODIUM EDTA
	POLYQUATERNIUM-39	FRAGRANCE
	POLYQUATERNIUM-7	GLYCERIN
	TETRASODIUM EDTA	PEG-90 STEARATE
	D&C ORANGE NO. 4	METHYLCHLOROISOTHIAZOLINONE
	FD&C RED NO. 40

[0170] Phase stability and foam performance attributed to combinations of additives—Several tested compositions, especially those containing a combination of cetyl (or cetearyl) alcohol, stearic acid, and/or glycerin, exhibited excellent foam stability.

[0171]

			Stable (S)/
			Not Stable	Bottle	Pump Foam
	Combinations	Formula	(NS)	Foam Test	Test
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	S	+++	++
		5GLY/0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	S	+++	++
		10GLY/0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	+++	++
		10GLY/0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	+++	++
		10GLY/0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
		10GLY/0.3CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
		10GLY/1.0CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
		10GLY/0.4CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	+++	++
		10GLY/0.2CETOH
	Glycerin/Stearic Acid	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
		10GLY/0.15STAC
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	+++	++
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13ALS/0.37CAPB/	S	+++	++
	Acid/Cetyl Alcohol	5GLY/0.05STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	S	+++	++
	Acid/Cetyl Alcohol	10GLY/0.025STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13ALS/0.37CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.2CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13ALS/0.37CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	7.5GLY/0.2CETOH/0.05STAC
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.02CETOH/0.05STAC
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.0ALS/0.5CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.15CETOH/0.05STAC
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.1STAC/0.2CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	10GLY/0.2CETOH/0.05STAC
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	5GLY/0.2CETOH/0.05STAC
	SLES2/Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13SLES2/0.37CAPB/	S	+++	++
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.15CETOH
	SLES2/Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5SLES2/0.5CAPB/	S	+++	++
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.15CETOH
	SLES2/Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13SLES2/0.37CAPB/	NS	NT	NT
	Acid/Cetyl Alcohol	7.5GLY/0.05STAC/0.2CETOH
	Cetyl Alcohol/PROMIDIUM CC	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	++	++
		0.3CETOH/0.5PCC
	Cetyl Alcohol/PROMIDIUM CC	0.6TCS/5DPG/15SXS/0.5CETOH/1.5PCC	NS	NT	NT
	Stearic Acid/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	+++	++
		0.15CETOH/0.025STAC
	Stearic Acid/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	S	+++	++
		0.15CETOH/0.05STAC
	Sodium PCA/Glycerin	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	S	−	−
		10GLY/.5PCA
	JAGHP60/MACKALINE SFES	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
		0.05JAGHP60/0.5SFES
	Sodium PCA/JAGHP60	0.3TCS/5DPG/15SXS/0.75ALS/	S	0	−
		0.05JAGHP60/1.0PCA
	JAGHP60/OLIVEM 400	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	+
		0.05JAGHP60/0.5OLIVM400
	Lauricidin/MACKALINE SPES	0.3TCS/5DPG/15SXS/0.75ALS/0.5SFES/	NS	NT	NT
		0.5LRCDN
	Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.25PQ10/	S	+++	++
	Alcohol/Glycerin/NaPCA	0.1CETOH/3GLY/1.5NaPCA
	LAMESOFT/Glycerin/NaPCA/	0.4TCS/5DPG/15SXS/0.75ALS/0.5LAMSFT/	S	+++	++
	JAGHP60	2.5GLY/1.5NaPCA/0.04JAGHP60/0.1CETOH
	NATROSOL HEC/PEG-75	0.3TCS/5DPG/15SXS/0.75ALS/	S	++	+
	Lanolin/PPG-5-Ceteth20	0.05NTSLHEC/0.5PEG-75LAN/0.5PPG5CET20
	NATROSOL HEC/Sunflower oil	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	0
		0.05NTSLHEC/1.0SUNFLWR
	NATROSOL HEC/GlycerinPOE	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	−
		0.05NTSLHEC/0.5GLYPOE
	NATROSOL HEC/NaPCA	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	−
		0.05NTSLHEC/1.0NaPCA
	JAGHP60/Sunflower oil	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	+
		0.04JAGHP60/1.0SUNFLWR
	JAGHP60/Sunflower oil/VitE	0.3TCS/5DPG/15SXS/0.75ALS/	S	−	+
		0.03JAGHP60/1.0SUNFLWR/0.01VitE
	JAGHP60/NaPCA	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
		0.05JAGHP60/0.5NaPCA
	NaPCA/MACKPRO WLW/JAGHP60/	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	−
	Aloe Vera	0.04JAGHP60/1.0NaPCA/0.5WLW/0.01AV
	NaPCA/ISML/JAGHP60/Aloe	0.3TCS/5DPG/15SXS/0.75ALS/	S	++	+
	Vera	0.04JAGHP60/1.0NaPCA/0.5ISML/0.01AV
	NaPCA/MACKALENE 1216/	0.3TCS/5DPG/15SXS/0.75ALS/	S	+	+
	JAGHP60/VitaminEOAc	0.04JAGHP60/1.0NaPCA/0.5M1216/0.01VitE
	NaPCA/Glycerin/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	S	+++	++
	Alcohol	1.5NaPCA/3.8GLY/0.1CETOH/0.1ALOE
	NaPCA/Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.5NaPCA/	S	+++	NT
	Alcohol/LAMESOFT	0.25CQSC240C/0.1CETOH/0.5LMSFT
	NaPCA/Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.5NaPCA/	S	+++	NT
	Alcohol/VARISOFT	0.25CQSC24OC/0.1CETOH/0.5VRSFT
	NaPCA/Polyquat10/Cetyl	0.3TCS/5DPG/15SXS/0.75ALS/0.5LMSFT/	S	++	++
	Alcohol/Glycerin/LAMESOFT	0.5NaPCA/3GLY/0.1CETOH/0.25CQSC240C
	NaPCA/Polyquat10/Cetyl	0.3TCS/5DPG/15SXS/0.75ALS/1.0NaPCA/	S	++	++
	Alcohol/Glycerin	3GLY/0.1CETOH/0.25CQSC240C

[0172] Antimicrobial Performance in Time Kill Tests. Results for antimicrobial efficacy are summarized in the following table—Unless otherwise indicated, the values are for log reduction of Serratia marcescens at 30 seconds. Values for “Sa,” “Ec,” and “Kp” refer to Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, respectively, at 30 seconds. The log reduction value for the test composition appears first, followed by the log reduction value for an appropriate control sample (in the table below, “//(cna)” means control not available). A log reduction value within about 1 log of the control sample is considered highly efficacious. Values for Serratia marcescens vary somewhat, between about log 2 to >log 4 reduction, for control samples.

[0173]

	Description	Formula	Time Kill Results
	Control Formula 1	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB	>4.14(Sa30)/>4.60(Ec30)
	Control Formula 2	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB	4.73/—
	Control Formula 3	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB	2.74/—
	Control Formula 4a	0.3TCS/5DPG/15SXS/0.75ALS	>4.91/—
	Control Formula 4b	0.3TCS/5DPG/15SXS/0.75ALS	>4.86/—
	Control Formula 4c	0.3TCS/5DPG/15SXS/0.75ALS	3.15/—
	Control Formula 4d	0.3TCS/5DPG/15SXS/0.75ALS	>4.83/—
	Control Formula 4e	0.3TCS/5DPG/15SXS/0.75ALS	3.17/—
	Control Formula 4f	0.3TCS/5DPG/15SXS/0.75ALS	>4.90(Sa)/—
			>5.00(Ec)/—
			4.47(Kp)/—
			2.97(Sm)/—
	Control Formula 4g	0.6TCS/5DPG/15SXS/1.5ALS/1PCC	4.28
	Sodium PCA/JAGHP60	0.3TCS/5DPG/15SXS/0.75ALS/0.05JAGHP60/	2.99/—
	(used as an “approximate”	1.0PCA
	control) (Control 5)
	Primary Surfactants
	Sodium Lauryl Ether	1.0TCS/5DPG/15SXS/2.5SLES2/0.75CAPB	>4.69(Sa30)/4.54(Ec30)//
	Sulfate (2-mole)		(cna)
	Ammonium Cocyl	1.0TCS/5DPG/15SXS/2.5ACI/0.75CAPB	>4.69(Sa30)/4.29(Ec30)//
	Isethionate		(cna)
	Polymers
	PVP K30	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/	>4.14(Sa)/>4.60(Ec)//>4.14/
		0.1PVPK30	>4.60(1)
	JAGUAR HP-60	0.3TCS/5DPG/15SXS/0.75ALS/0.1HP60	>4.86/>4.86(4b)
	CELQUAT SC-230M	0.3TCS/5DPG/15SXS/0.75ALS/0.1CQSC230M	>4.86/>4.86(4b)
	CELQUAT SC-230M	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	4.38/4.73(2)
		0.5CQSC230M
	CELQUAT H-100	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/	4.38/4.73(2)
		0.5CQH100
	NATROSOL 250 HHR	0.3TCS/5DPG/15SXS/0.75ALS/0.05NATSOL250HHR	>4.86/>4.86(4b
	CARBOWAX 540	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	4.73/>4.73(4d)
		1.0CWAX540
	CARBOWAX 900	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	4.63/>4.73(4d)
		1.0CWAX900
	FLEXAN 130	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	4.63/>4.73(4d)
		1.0FLEX130
	Protein Derivatives
	MACKPRO WWP	0.3TCS/5DPG/15SXS/0.75ALS/1.0WWP	3.41/>4.91(4a
	MACKPRO WWP	0.3TCS/5DPG/15SXS/0.75ALS/0.5WWP	3.95/>4.91(4a)
	MACKPRO NLW	0.3TCS/5DPG/15SXS/0.75ALS/0.2NLW	>4.86/>4.86(4b)
	Silicone Derivatives
	Dimethicone Propyl PG	0.3TCS/5DPG/15SXS/0.75ALS/0.2DIMETHPGB	>4.86/>4.86(4b)
	Betaine
	Stearyl Methicone	0.3TCS/5DPG/15SXS/0.75ALS/0.05STMETH	3.60/>4.91(4a)
	Dow Corning 193	0.3TCS/5DPG/15SXS/0.75ALS/0.2DC193	4.41/>4.86(4b)
	Humectants
	Glycerin	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/5GLY	>4.14(Sa)/>4.60(Ec)//>4.14/>4.60(1)
	Sodium PCA	0.3TCS/2DPG/15SXS/0.75ALS/0.5PCA	>4.86/>4.86(4b)
	Ethoxylated Derivative
	Polyoxyethylene (2)	0.6TCS/5DPG/15SXS/1.5ALS/0.4BRIJ72	2.31/4.28(4g)
	stearyl ether (BRIJ 72)
	Polyoxyethylene (21)	0.6TCS/5DPG/15SXS/1.5ALS/1.0BRIJ721	2.33/4.28(4g)
	stearyl ether (BRIJ 721)
	ARLASOLVE 200	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/
		1.0ARL200
	PEG7 Glyceryl Cocoate	0.3TCS/5DPG/15SXS/0.75ALS/0.5PEG7GC	>4.86/>4.86(4b)
	LAMESOFT	0.3TCS/5DPG/15SXS/0.75ALS/0.1LMSFT	3.73/>4.91(4a)
	Long-chain Fatty
	Materials
	Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/0.05CETOH	2.56/2.74(3)
	Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/0.2CETOH	2.70/2.74(3)
	Cetyl alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/0.1CETOH	2.65/2.74(3)
	Stearic Acid	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/0.2StAc	>4.14(Sa)/>4.60(Ec)//>4.14/
			>4.60(3)
	Lipid-like Materials
	Canola Oil	0.6TCS/5DPG/25SXS/1.5ALS/0.75CAPB/10GLY/	2.96/3.15(4c)
		0.1CANOL
	Other Emollients
	MACKERNIUM 1216	0.3TCS/5DPG/15SXS/0.75ALS/0.1MAC1216	>4.86/>4.86(4b)
	PROMIDIUM CC	0.6TCS/5DPG/15SXS/1.5ALS/1PCC	4.28/4.28(4g)
	ISML	0.3TCS/5DPG/15SXS/0.75ALS/0.1ISML	4.76/>4.86(4b)
	ISML	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/0.21ISML	>4.69(Sa30)/4.06(Ec)//
			(cna)
	Sr(OAc)2	1.0TCS/5DPG/15SXS/2.5ALS/0.75CAPB/	>4.69(Sa30)/3.24(Ec30)//
		0.2Sr(OAc)2	(cna)
	JEECHEM GL-26	0.3TCS/5DPG/15SXS/0.75ALS/0.2JCHMGL26	>4.86/>4.86(4b)
	Combinations
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/5GLY/	2.77/2.74(3)
		0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/10GLY/	3.00/2.74(3)
		0.2CETOH
	Glycerin/Cetyl Alcohol	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/10GLY/	2.38/3.15(4c)
		0.2CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5ALS/0.75CAPB/10GLY/	2.46/3.15(4c)
	Acid/Cetyl Alcohol	0.05STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13ALS/0.37CAPB/5GLY/	2.41/3.15(4c)
	Acid/Cetyl Alcohol	0.05STAC/0.15CETOH
	Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13ALS/0.37CAPB/10GLY/	2.70/3.15(4c)
	Acid/Cetyl Alcohol	0.05STAC/0.15CETOH
	SLES2/Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.13SLES2/0.37CAPB/	2.30/3.15(4c)
	Acid/Cetyl Alcohol	10GLY/0.05STAC/0.15CETOH
	SLES2/Glycerin/Stearic	0.6TCS/5DPG/15SXS/1.5SLES2/0.5CAPB/10GLY/	2.31/3.15(4c)
	Acid/Cetyl Alcohol	0.05STAC/0.15CETOH
	Stearic Acid/Cetyl	0.6TCS/5DPG/15SXS/1.5ALS/0.5CAPB/	2.59/3.15(4c)
	Alcohol	0.15CETOH/0.05STAC
	JAGHP60/MACKALINE SFES	0.3TCS/5DPG/15SXS/0.75ALS/0.05JAGHP60/	1.22/2.99(5)
		0.5SFES
	JAGHP60/OLIVEM 400	0.3TCS/5DPG/15SXS/0.75ALS/0.05JAGHP60/	1.37/2.99(5)
		0.5OLIVM400
	Sodium PCA/JAGHP60	0.3TCS/5DPG/15SXS/0.75ALS/0.05JAGHP60/	2.99/2.99(5)
		1.0PCA
	Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/0.25CQS	4.30/>4.83(4d)
	Alcohol/Glycerin/NaPCA/	C240C/0.1CETOH/3GLY/1.5NaPCA/0.1ALOE
	Aloe Vera
	LAMESOFT/Glycerin/NaPCA/	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	4.53/>4.83(4d)
	JAGHP60/Aloe Vera	0.5LAMSFT/2.5GLY/1.5NaPCA/0.04JAGHP60/
		0.1ALOE
	NATROSOL HEC/PEG-75	0.3TCS/5DPG/15SXS/0.75ALS/0.05NTSLHEC/	0.79/2.99(5)
	Lanolin/PPG-5-Ceteth20	0.5PEG-75LAN/0.5PPG5CET20
	NATROSOL HEC/Sunflower	0.3TCS/5DPG/15SXS/0.75ALS/0.05NTSLHEC/	1.22/2.99(5)
	oil	1.0SUNFLWR
	NATROSOL HEC/GlycerinPOE	0.3TCS/5DPG/15SXS/0.75ALS/0.05NTSLHEC/	1.53/2.99(5)
		0.5GLYPOE
	NATROSOL HEC/NaPCA	0.3TCS/5DPG/15SXS/0.75ALS/0.05NTSLHEC/	2.16/2.99(5)
		1.0NaPCA
	JAGHP60/Sunflower oil	0.3TCS/5DPG/15SXS/0.75ALS/0.04JAGHP60/	1.43/2.99(5)
		1.0SUNFLWR
	JAGHP60/SunflowerOil/VitE	0.3TCS/5DPG/15SXS/0.75ALS/0.03JAGHP60/	2.16/2.99(5)
		1.0SUNFLWR/0.01VitE
	JAGHP60/NaPCA	0.3TCS/5DPG/15SXS/0.75ALS/0.05JAGHP60/	3.95/>4.91(4a)
		0.5NaPCA
	NaPCA/MACKPROWLW/JAGHP60/	0.3TCS/5DPG/15SXS/0.75ALS/0.04JAGHP60/	3.14/3.17(4e)
	Aloe Vera	1.0NaPCA/0.5WLW/0.01AV
	NaPCA/ISML/JAGHP60/Aloe	0.3TCS/5DPG/15SXS/0.75ALS/0.04JAGHP60/	3.00/3.17(4e)
	Vera	1.0NaPCA/0.5ISML/0.01AV
	NaPCA/Mackalene1216/	0.3TCS/5DPG/15SXS/0.75ALS/0.04JAGHP60/	1.88/3.17(4e)
	JAGHP60/VitaminEOAc	1.0NaPCA/0.5M1216/0.01VitE
	NaPCA/Glycerin/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	4.58/>4.83(4d)
	Alcohol/Aloe Vera	1.5NaPCA/3.8GLY/0.1CETOH/0.1ALOE
	NaPCA/Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	>4.73/>4.73(4d)
	Alcohol/LAMESOFT/Aloe	0.5NaPCA/0.25CQSC240C//0.1CETOH/0.5LMSFT/
	Vera	0.1ALOE
	NaPCA/Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	4.25/>4.73(4d)
	Alcohol/VARISOFT/Aloe	0.5NaPCA/0.25CQS240C//0.1CETOH/0.5VRSFT
	Vera	0.1ALOE
	NaPCA/Polyquat10/Cetyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	>4.90(Sa)/>4.90(4f)
	Alcohol/Glycerin/Aloe	1.0NaPCA/3GLY/0.1CETOH/0.25CQSC240C/	>5.00(Ec)/>5.00(4f)
	Vera	0.1ALOE	4.65(Kp)/4.47(4f)
			2.94(Sm)/2.97(4f)
	NaPCA/Polyquat10/Cetearyl	0.4TCS/5DPG/15SXS/0.75ALS/0.75CAPB/	>4.90(Sa)/>4.90(4f)
	Alcohol/Glycerin/Aloe	0.5LMSFT/0.5NaPCA/3GLY/0.1CETOH/	>5.00(Ec)/>5.00(4f)
	Vera	0.25CQSC240C/0.1ALOE	4.70(Kp)/4.47(4f)
			2.85(Sm)/2.97(4f)

[0174] Antimicrobial Performance Tests (Broad Spectrum Efficacy)—The following embodiment of the present invention was tested:

• • [0175] COMPOSITION A (by weight): 0.46 TCS/5DPG/15SXS/0.75CAPB/0.129 Disodium Phosphate/0.066 Citric Acid, buffer (pH≅6)/0.1 Cetyl Alcohol/0.05 fragrance/1 Sodium PCA/2.97GLY/0.25 Polyquaternium-100/0.1 Aloe Vera Gel/0.15 Methyl Paraben/0.05 Propylparaben/0.00005 FD&C Red #4/0.000025 Yellow #5.

[0176] Time kill tests were performed to compare Composition A of the present invention to several commercially available Health Care Personnel Hand Wash products (i.e., HCPHW-E, F, G, H. I, J) and to several commercially available retail antibacterial hand wash products. Three nonmedicated retail liquid hand soaps also were tested for comparison. The tests evaluated efficacy against a broad spectrum of twenty-four different microorganisms. Test organisms were selected to represent both transient and resident organisms, Gram negative bacteria (such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium), and Gram positive bacteria (such as Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes). The compositions were tested with sampling taking place at 30 seconds and 1 minute.

[0177] The test organisms represented a broad spectrum of both Gram positive and Gram negative organisms commonly associated with nosocomial infections. For the health care products, five additional test organisms were added as a result of a health care survey, including several antibiotic resistant strains of bacteria. The following Time Kill Summary charts summarize bacterial kill results for Composition A vs. several Health care Personnel Hand wash Products.

[0178] The Time Kill Summary charts summarize data for both Health care Personnel Hand washes and retail liquid hand soaps, and includes a number of organisms of the total tested that were reduced by greater than 3, 2, or 1 log within 30 seconds. Antimicrobial potential can be classified based on a product's ability to reduce the number of organisms in logarithms. A product that is unable to achieve a 1 log reduction shows minimal activity against that specific organism. A one log reduction is considered moderate activity, whereas a greater than 2 or 3 log reduction is considered strong antibacterial activity in vitro.

[0179] The summarized results demonstrate a significantly superior efficacy for Composition A versus the twenty-four test organisms (30 second time-kill). Composition A performed significantly better than each of the commercially available Health Care Personnel Hand Wash products tested (i.e., HCPHW-E through J) at reducing the number and type of microorganisms encountered in health care settings. Further, compared to the leading liquid hand soaps and health care products, Composition A was superior at reducing more types of test organisms by greater than 3 logs within 30 seconds. Composition A reduced 19 of 24 organisms tested by greater than 3 log units within 30 seconds. The closest comparative composition, HCPHW-I, reduced 16 of 24 organisms greater than 3 log units. The remaining comparative compositions showed moderate to minimal antimicrobial activity.

[0180]

Time Kill Summary-I
Log Reduction
		Commercial	Commercial	Commercial	Commercial	Commercial
	Composition	Product	Product	Product	Product	Product
	A	HCPHW-E	HCPHW-F	HCPHW-G	HCPHW-H	HCPHW-I
	30	1	30	1	30	1	30	1	30	1	30	1
Test Organisms	Sec.	Min.	Sec.	Min.	Sec.	Min.	Sec.	Min.	Sec.	Min.	Sec.	Min.
Staphylococcus aureus	5.07	>5.17	1.31	2.14	1.05	1.43	2.98	4.38	1.75	2.55	2.94	4.23
(ATCC 6538)
Staphylococcus	3.35	4.41	0.46	0.47	0.23	0.42	0.38	0.65	0.78	1.00	5.02	4.66
epidermis (ATCC 12228)
Stphylococcus aureus	0.98	1.93	0.05	0.17	0.10	0.12	0.31	0.50	0.19	0.23	1.73	2.80
MRSA (ATCC 33592)
Streptococcus	>3.07	>3.07	>3.07	>3.07	>3.07	>3.07	>3.07	>3.07	>3.07	>3.07	1.91	1.55
pneumoniae (ATCC 6303)
Streptococcus pyogenes	>4.11	>4.11	4.01	>4.11	3.80	>4.11	>3.98	>3.98	>4.11	>4.11	>3.97	>3.97
(ATCC 19615)
Pseudomonas aeruginosa	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23	>5.23
(clinical isolate)
Pseudomonas aeruginosa	>5.25	>5.25	>5.25	>5.25	>5.25	>5.25	>5.25	>5.25	>5.25	>5.25	>4.21	>4.21
(ATCC 9027)
Klebsiella pneumoniae	>5.07	>5.07	2.26	2.76	4.52	>5.07	5.02	>5.07	3.45	4.18	>4.27	>4.27
(ATCC 11296)
Burkholderia cepacia	>4.92	>4.92	0.00	0.05	1.56	4.59	2.08	4.92	0.05	0.47	2.42	1.65
(ATCC 25416)
Serratia marcescens	3.96	>5.47	0.16	0.27	0.02	0.07	0.15	0.51	0.18	0.23	>4.59	>4.59
(ATCC 14756)
Shigella sonnei	4.22	>5.23	3.75	5.03	0.63	1.63	2.33	5.23	3.65	>5.23	4.18	>4.36
(ATCC 11060)
Salmonella choleraseuis	>5.27	>5.27	1.83	3.66	0.67	1.32	5.07	>5.27	1.31	2.91	>5.64	>5.64
(ATCC 13076)
Salmonella choleraseuis	>5.20	>5.20	2.02	>5.20	0.93	3.56	5.04	>5.20	3.14	>5.20	>4.59	>4.59
(typhi) (ATCC 6539)
Stenotrophomonas	>5.11	>5.11	4.95	4.89	>5.11	4.95	>5.11	>5.11	>5.11	>5.11	>4.97	>4.97
maltophilia (ATCC
13637)
Enterobacter aerogenes	2.61	>5.23	0.43	0.63	0.30	0.45	0.56	1.46	0.60	0.73	2.60	3.78
(ATCC 13048)
Escherichia coli	>5.14	>5.14	0.72	1.06	0.66	0.96	1.10	1.89	2.08	2.70	>4.32	>4.32
(ATCC 11229)
Escherichia coli	2.51	>4.98	0.96	2.71	0.45	1.29	2.29	>4.98	1.32	2.65	>4.22	>4.22
O:157H:7
(ATCC 43888)
Citrobacter freundii	3.46	>4.88	0.64	1.56	0.97	1.50	4.66	>4.88	0.44	0.61	>4.28	>4.28
(ATCC 43864)
Enterococcus faecium	3.37	4.26	0.53	1.38	0.32	0.72	2.67	4.05	0.72	1.95	0.30	0.54
(ATCC 51559)
Enterococcus faecalis	>5.98	>5.98	0.78	2.30	1.08	2.06	4.23	5.41	1.08	2.38	0.75	1.20
(ATCC 51299)
Clostridium difficile	3.44	3.56	>4.14	>4.14	>4.14	>4.14	>4.14	>4.14	>4.14	>4.14	>4.14	>4.14
(ATCC 9689)
Candida albicans	1.78	3.05	0.44	1.08	0.09	0.33	0.20	1.08	0.37	0.83	2.07	2.63
(ATCC 10231)
Candida tropicalis	2.01	2.85	1.12	2.12	0.25	0.42	0.28	0.79	1.32	2.36	>4.36	>4.76
(ATCC 750)
Shodotorula rubra	>5.14	>5.14	2.05	2.68	2.60	4.32	4.91	>5.14	2.52	3.33	>4.74	>4.74
(ATCC 9449)

[0181]

Time Kill Summary-II @
30 seconds
		Retail-CS
Composition A	Formula AA-1 1)	(nonmed.)
19 organisms > 3 log or 99.9%	16 > 3 log	2 > 3 log
2 organisms > 2 log or 99%	2 > 2 log	0 > 2 log
2 organisms > 1 log or 90%	1 > 1 log	1 > 1 log
1 organism < 1 log	0 < 1 log	16 < 1 log
HCPHW-I	HCPHW-J	Retail-EAB
16 organisms > 3 log or 99.9%	8 > 3 log	1 > 3 log
4 organisms > 2 log or 99%	2 > 2 log	2 > 2 log
2 organisms > 1 log or 90%	2 > 1 log	1 > 1 log
2 organisms < 1 log	7 < 1 log	15 < 1 log
HCPHW-G	Retail-SAB	Retail-SSA
10 organisms > 3 log or 99.9%	5 > 3 log	1 > 3 log
5 organisms > 2 log or 99%	1 > 2 log	2 > 2 log
1 organism > 1 log or 90%	1 > 1 log	1 > 1 log
8 organisms < 1 log	12 < 1 log	15 < 1 log
		Retail-SSM
HCPHW-H	Retail-KAB	(nonmed.)
9 organisms > 3 log or 99.9%	3 > 3 log	1 > 3 log
2 organisms > 2 log or 99%	1 > 2 log	0 > 2 log
5 organisms > 1 log or 90%	6 > 1 log	1 > 1 log
8 organisms < 1 log	9 < 1 log	17 < 1 log
		Retail-ILS
HCPHW-E	Retail-PAB	(nonmed.)
7 organisms > 3 log or 99.9%	3 > 3 log	1 > 3 log
3 organisms > 2 log or 99%	1 > 2 log	1 > 2 log
3 organisms > 1 log or 90%	5 > 1 log	1 < 1 log
11 organisms < 1 log	10 < 1 log	16 < 1 log
HCPHW-F	Retail-SSP
7 organisms > 3 log or 99.9%	2 > 3 log
1 organism > 2 log or 99%	1 > 2 log
3 organisms > 1 log or 90%	1 > 1 log
13 organisms < 1 log	15 < 1 log
1) FORMULA AA-1 is a retail antibacterial formula produced in accordance with U.S. Pat. No. 6,107,261.

[0182] Antimicrobial Performance Tests (Health Care Personnel Hand Wash Test)—The FDA issued a tentative final monograph (Jun. 17, 1994) setting forth a health care personnel hand wash method to determine the effectiveness of antibacterial cleansing products. The following embodiment of the present invention was tested using this method:

• • [0183] Composition B (by weight): 0.04 TCS/5DPG/15SXS/0.75ALS/0.75CAPB/0.129 Disodium Phosphate/0.066 Citric Acid, buffer (pH≅6)/0.1 Cetyl Alcohol/0.05 fragrance/1.0 Sodium PCA/2.97GLY/0.25 Polyquaternium-100/0.1 Aloe Vera Gel/0.15 Methyl Paraben/0.05 Propylparaben/0.00005 FD&C Red #4/0.000025 Yellow #5.

[0184] The in-use antibacterial efficacy of Composition B was determined by a health care personnel hand wash study. The study was performed according to the current revision of ASTM E-1174-00, Standard Test Method for Evaluation of the Effectiveness of Health Care Personnel or Consumer Hand wash Formulations, incorporated herein by reference. The revision to the test method provides procedures to assure adequate rapid neutralization of the antimicrobial in the hand wash formulation. A neutralizer was incorporated at both sampling points. The study is designed to measure the reduction of transient microbial flora following routine hand washing with an antibacterial product. In this study, a broth culture of Serratia marcescens ATCC₁₄₇₅₆ was used as an artificial contaminant bacteria on the hands. Activity was measured by comparing the microbial counts of the marker organism removed after a single use of the test composition to the baseline number, i.e., the number of organisms recovered from contaminated, unwashed hands. Additional comparisons were made following the tenth wash of a multiple wash procedure.

[0185] Prior to each of the eleven washes, the hands were artificially contaminated with S. marcescens. In addition to testing Composition B, HCPHW-I also was included in the study. A sufficient number of subjects fulfilling the study criteria were preenrolled to ensure the required number of subjects (45), 30 for Composition B and 15 for HCPHW-I. During a one-week wash out period, the subjects refrained from using antimicrobial-containing products. On the test day, subjects' hands were contaminated with S. marcescens and a baseline sampling was performed. Following washing with the test composition, and following treatments 1 and 10, the subjects' hands were sampled for a post-treatment count. The sampling fluid was enumerated for recovery of S. marcescens. Results from the Health Care Personnel Hand Wash study were evaluated by comparing bacteria counts recovered from the hands following product treatment vs. the baseline counts. The bacteria counts were converted into log₁₀ counts. The log counts of each subject's left and right hand were averaged. The following log₁₀ reductions were observed:

[0186]

	Product Description	WASH 1	WASH 10
	Composition B	3.47	3.58 2)
	HCPHW-I	2.50	3.78 2)
	2) No statistical difference between the test compositions.

[0187] For antiseptic hand wash or health care personnel hand wash products, as proposed in the Tentative FDA Monograph (Health care Antiseptic Drug Products), the following criteria should be met: a 2 log reduction of the marker organism on each hand within 5 minutes after the first wash and a 3 log reduction of the marker organism on each hand within 5 minutes following the tenth wash.

[0188] Composition B met and surpassed both of these criteria. When compared to HCPHW-I, Composition B performed significantly better with respect to reducing the concentration of the marker organism after one wash, and was equally effective following the tenth wash. The demonstrated log reductions illustrate that the present compositions are effective as Health Care Personnel Hand wash products.

[0189] Repeat Application Soap Chamber Test—A soap chamber irritation test was performed to determine the mildness of Composition A vs. several commercially available Health Care Personnel Hand Wash products. The tests showed that: (a) all test compositions were significantly less irritating than the positive control, i.e., a dilute solution of sodium lauryl sulfate (SLS), and (b) ranking products from highest irritation potential to lowest is: SLS>HCPHW-E>HCPHW-H>HCPHW-G>HCPHW-F>Composition A>Negative Control.

Methodology

[0190] Twelve male and female subjects between the ages of 18 and 65, who were in good health, were enrolled in the test. Dilute solutions of all test compositions were made each day of patching. Patches were totally occlusive chambers, 12 mm in diameter, applied to the volar forearm for a total of six days. Expert visual gradings, using a four-point scale for erythema, scaling, and fissuring were used as the objective measure of observation for this study. Grading was performed at baseline (i.e., when panelists were enrolled), 30 minutes after patch removal on days one to six, and at 24 hours on days one to six. A maximum for each tested characteristic was established as a “3” score.

Summary

[0191] The rating for the commercially available hand wash products, from highest irritation potential to the lowest, was: Positive Control>HCPHW-E>HCPHW-H>HCPHW-G>HCPHW-F>Composition A>Negative Control. Significant differences were noted overall between HCPHW-E and HCPHW-H, compared to HCPHW-G, HCPHW-F, and Composition A. Directional differences existed between Composition A, HCPHW-F, and HCPHW-G, with Composition A demonstrating the lowest irritation potential as measured under the conditions of the test.

[0192]

TABLE 1
Professional Products Statistical Groupings
	Mean Summary
Product	Score	Statistical Grouping
Positive Control	11.8	I
HCPHW-E	3.9		II	III
HCPHW-H	2.2		II	III	IV
HCPHW-G	1.3			III	IV	V
HCPHW-F	1.0				IV	V
Composition A	0.9				IV	V
Negative Control	0.0					V

[0193] Occupational Hand Wash Study (Health care Personnel)—The following embodiment of the present invention was used in this test:

[0194] Composition C (by weight): 0.40 TCS/5DPG/15SXS/0.75ALS/0.75CAPB/0.129 Disodium Phosphate/ 0.066 Citric Acid, buffer (ph≅6)/0.1 Cetyl Alcohol/0.05 fragrance/1 Sodium PCA/2.97GLY/0.25 Polywaternium-100/0.1 Aloe Vera Gel/0.00005 FD&C Red #4/0.000025 Yellow #5.

[0195] Composition C was tested vs. commercially available HCPHW-E in an occupational hand wash study. It is expected that a health care worker would have a greater exposure over an extended time period to a hand wash than the general public. Accordingly, this test was designed to mimic the population demographics and hand wash patterns likely to be encountered in a health care setting. HCPHW-E was selected based on its prior acceptance in the health care industry as being an efficacious and mild health care personnel hand wash.

Methodology

[0196] The study demographics were selected to mimic a population cross section encountered in a health care setting. Thirty-eight volunteers, who were in good general health, participated in the study. The panel included nine volunteers with clinically assessed “dry skin,” and twenty-nine volunteers with clinically assessed “normal skin.” These determinations were made by an expert grader following a two-week preconditioning period during which all volunteers washed with a commercially available mild skin care soap bar and discontinued the use of all topically applied moisturizers, creams, lotions, and antibacterial products. Each panelist was qualified for participation after the two-week preconditioning period. The age range of the panelists was between 20 and 55 years of age, and the sex distribution was three males and thirty-five females.

[0197] The test compositions were coded and sent to an independent laboratory for testing. The test was a single-blind study in which only the wash monitors were aware of the coded product assignments when the products were applied to the hand and volar forearm. All wash procedures were conducted in a separate area in order to maintain blinding of the expert grader and instrument operators. The test materials were dispensed by a wash monitor into the hand of the panelists during the wash procedure.

[0198] Using appropriate randomization, panelists were assigned a wash partner for “skin-to-skin” friction. Composition C was applied to dry skin and spread over the hand and forearm for 30 seconds. Immediately thereafter, the panelists were instructed to rinse the hand and forearm for 15 seconds. The skin was patted dry with a disposable towel. HCPHW-E was applied to wetted skin and spread over the designated hand and forearm for 30 seconds. Immediately following, panelists were instructed to rinse the hand and forearm for 15 seconds. The skin was patted dry with a disposable towel. The time between wash cycles was approximately five minutes. The time between the tenth cycle and grading was approximately twenty minutes. These protocols were chosen to represent typical in-use scenarios envisioned for both samples used as commercial products.

[0199] To determine the effects that the two test compositions had on panelists' skin, both visual expert grading and instrumental evaluations were used. Expert grading involved the “Dryness,” “Erythema,” and “Tactile Roughness” scales summarized below. Base line expert gradings and instrumental measurements were taken between the start of the first wash cycle on day one. Each panelist was graded, then participated in ten (10) wash cycles in the morning, graded again, and then subjected to ten (10) wash cycles in the afternoon. Instrumental measurements were taken at termination of use of a composition, or at completion of the study.

[0200]

Dryness
0 = None
1 = Slight flaking or occasional small lifting of scales
2 = Moderate flaking/scaling
3 = Marked scaling/slight fissuring, cracking, lifting of scales
4 = Severe scaling, cracking, and fissuring
Erythema
0 = None
1 = Mild diffuse erythema, limited to a small area
2 = Moderate pinkness, more extensive area
3 = Marked erythema, may include deeper areas of erythema/slight edema
4 = Severe erythema, or presence of edema, fissuring, possible erosions
Tactile Roughness
0 = Normal
1 = Slight roughness
2 = Moderate roughness
3 = Severe roughness
4 = Extreme roughness

[0201] At the end of the study, the subjects completed a questionnaire directed to their perception of dryness, tightness, itching, and burning for each hand/arm. The scale used for rating was:

[0202]

Self-assessment
No dryness	0	1	2	3	4	severe dryness
No tightness	0	1	2	3	4	severe tightness
No itching	0	1	2	3	4	severe itching
No burning/soreness	0	1	2	3	4	severe burning/soreness

Results

[0203] The tests used in this study are summarized in the following table.

[0204]

	Observation of number of	indicates panelists' ability
	panelists able to complete	to tolerate composition in
	test	high use situation; more
		panelists able to complete
		test = milder product
	Visual Expert Grading	dryness, erythema, roughness;
		lower reading = milder product
	Panelist Self-assessment	perception of dryness,
		tightness, itching,
		burning/soreness; lower
		reading = milder product
	Minolta Chromameter	instrumental reading of skin
		redness; lower reading = skin
		less irritated
	Transepidermal Water Loss	instrumental assessment of
	(TEWL)	skin barrier function; lower
		reading = less damage to skin
		barrier function

Number of Panelists Able to Complete Test

[0205] The number of panelists able to complete all washings was significantly greater with Composition C than with HCPHW-E. In addition, the total number of washings completed without significant redness, dryness, and roughness was higher for Composition C than for HCPHW-E. Less dryness and redness was observed on forearms washed with Composition C than forearms washed with HCPHW-E. These results are illustrated in the graphs of FIG. 1A and FIG. 1B.

Visual Expert Grading

[0206] Expert Grader Evaluations were performed using a four-point scale on panelist dorsal hands, webbing of fingers, and volar forearms for qualitative measurements of dryness, erythema (redness), and tactile roughness. The “Total Panel” consisted of all panelists, i.e., those with normal skin and with dry skin. Less dryness and redness were observed on forearms washed with Composition C than those washed with HCPHW-E. For dry skin subjects, the expert grader assessed determined that the panel experienced less redness while using Composition C was used. The results are illustrated in the following two tables.

[0207]

Expert Grader Assessment of Total Panel
	Webbing of	Webbing of
	Fingers	Fingers	Dorsal Hand	Dorsal Hand	Volar Forearms	Volar Foreamrs
	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E
Dryness
Mean	1.2	1.0	1.2	1.0	1.0	1.1
Standard	0.9	0.7	0.8	0.8	0.7	0.7
Deviation
Paired T-Test	0.35	0.34	0.81
Roughness
Mean	1.9	1.5	1.7	1.5	1.1	1.1
Standard	0.7	0.7	0.8	0.7	0.4	0.4
Deviation
Paired T-Test	0.00	0.01	0.86
Erythema
Mean	1.0	1.1	1.6	1.6	2.1	2.8
Standard	0.6	0.7	0.6	0.5	0.9	0.6
Deviation
Paired T-Test	0.45	0.45	0.00

[0208]

Expert Grader Assessment of Panelists with Dry Skin (Termination and EndPoint Scores)
	Webbing of	Webbing of
	Fingers	Fingers	Dorsal Hand	Dorsal Hand	Volar Forearms	Volar Forearms
	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E
Dryness
Mean	1.2	0.2	1.4	1.5	1.0	1.0
Standard	0.54	0.53	0.77	1.2	1.0	0.74
Deviation
Paired T-Test	0.02	0.97	0.95
Roughness
Mean	1.9	1.9	2.3	2.3	1.1	1.1
Standard	0.46	0.38	0.65	0.36	0.51	0.49
Deviation
Paired T-Test	0.86	0.63	1.0
Erythema
Mean	1.0	1.1	1.4	2.0	1.9	2.8
Standard	0.46	0.60	.049	0.78	0.98	0.51
Deviation
Paired T-Test	0.12	0.10	0.04

Panelist Self-Assessment

[0209] Panelist perception of the test compositions was obtained at the end of the study. The scale used by the subjects to assess the composition as set forth in the methodology section. Panelists were asked to rank their overall impression of the two test composition for four characteristics: dryness, tightness, itching, and burning. The perception for the total panel ranked Composition C as being significantly less drying and experiencing significantly less tightness, less itching sensation, and less burning than HCPHW-E. The results are summarized in the following tables.

[0210]

Self-Assessment at End of Study
	Dryness	Dryness	Tightness	Tightness	Itching	Itching	Burning	Burning
	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E
Mean	2.1	2.6	2.1	2.7	1.3	2.2	1.7	2.9
Std.	1.1	1.3	1.2	1.2	1.2	1.3	1.4	1.3
Dev.
Paired	0.0039	0.0056	0.0002	0.0000
T-test

[0211]

Self-Assessment at End of Study (Dry Skin Panelists Only)
	Dryness	Dryness	Tightness	Tightness	Itching	Itching	Burning	Burning
	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E	Composition C	HCPHW-E
Mean	2.3	2.4	2.1	2.3	1.8	2.1	1.8	2.8
Std.	0.7	1.2	1.2	1.4	1.2	1.8	1.4	1.3
Dev.
Paired	0.799	0.729	0.594	0.067
T-test

Minolta Chromameter

[0212] A Minolta Chromameter was used to quantify the change in surface redness of skin exposed to the wash cycles on both the dorsal hand and volar forearm surface. Measurements are taken along a red color spectrum, with increasing irritation represented by increasing redness along the color spectrum. Both the dorsal hand and volar forearm measurements were consistent with the Expert Grader assessments. The dorsal hand surface was significantly less red for sites washed with Composition C than sites washed with HCPHW-E. The volar forearm demonstrated an even greater difference between sites washed with Composition C and HCPHW-E. In particular, Composition C exhibited very minor changes in redness at the sites where measurements were taken. Chromameter values at end-point and termination show that Composition C is significantly less irritating the HCPHW-E. The results are summarized in FIG. 2.

Transepidermal Water Loss (TEWL)

[0213] Transepidermal Water Loss (TEWL) values for the total panel, at termination of the test, demonstrate that Composition C causes significantly less damage to the skin surface than HCPHW-E. Normally, the skin surface has barrier functions, both protecting from external influences and preserving internal balances. TEWL is a measurement that quantifies the amount of water escaping from the skin surface as a result of damage due to washing with a surfactant. Composition C produced significantly less damage to the skin surface, when quantified by water loss, than HCPHW-E on both the dorsal hand and volar forearm. The results are summarized in FIG. 3.

Summary

[0214] Under the conditions used in this example, Composition C is milder than HCPHW-E. Total panel self-assessments reported experiencing less dryness, tightness, itching, and burning when using Composition C. For dry skin subjects, expert grader assessments determined that the panel experienced less redness when using Composition C, and a greater ability to complete more washes when using Composition C. Dry skin panelists in the self-assessments, also reported experiencing less dryness, tightness, itching, and burning when using Composition C. Instrumental assessments for the whole panel significantly favored Composition C because of imparting significantly less damage to skin functions than HCPHW-E.

[0215] The examples show the unexpected benefits achieved by compositions of the present invention. The data presented above illustrate that a present antibacterial composition can contain ingredients to enhance product esthetics and to impart skin care properties, and can exhibit a log reduction of at least about 2 (after 30 seconds) or at least about 3 (after 60 seconds) vs. S. aureus, or of at least about 2.5 (after 30 seconds) or at least about 3.5 (after 60 seconds) vs. E. coli.

[0216] The antibacterial compositions of the present invention have several practical end uses, including hand cleansers, mouthwashes, surgical scrubs, body splashes, hand sanitizer gels, and similar personal care products. Additional types of compositions include foamed compositions, such as creams, mousses, and the like, and compositions containing organic and inorganic filler materials, such as emulsions, lotions, creams, pastes, and the like. The compositions further can be used as an antibacterial cleanser for hard surfaces, for example, sinks and countertops in hospitals, food service areas, and meat processing plants. The present antibacterial compositions can be manufactured as dilute ready-to-use compositions, or as concentrates that are diluted prior to use. The compositions can be applied to a surface, then either rinsed from, wiped from, or allowed to remain on the treated surface.

[0217] The compositions also can be incorporated into a web material to provide an antibacterial wiping article. The wiping article can be used to clean and sanitize skin or inanimate surfaces.

[0218] The present antimicrobial compositions provide the advantages of a broad spectrum kill of Gram positive and Gram negative bacteria in short contact times. The short contact time for a substantial log reduction of bacteria is important in view of the typical 15 to 60 second time frame used to cleanse and sanitize the skin and inanimate surfaces.

[0219] The present compositions are effective in short contact time because the antibacterial agent is present in the aqueous continuous phase of the composition, as opposed to surfactant micelles. The antibacterial agent, therefore, is available to immediately begin reducing bacterial populations, and further is available to deposit on the skin to provide residual antibacterial efficacy. In addition, because the antibacterial agent is in solution as opposed to surfactant micelles, the absolute amount of antimicrobial agent in the composition can be reduced without adversely affecting efficacy, and the antibacterial agent is not rinsed from the skin with the surfactant prior to performing its antibacterial function. In addition, the amount of surfactant in the present antibacterial compositions typically is low, thereby providing additional environmental benefits. Furthermore, the present compositions exhibit excellent esthetic properties, especially with respect to foam generation and foam stability, making the compositions useful in pump foam dispersers.

[0220] Obviously, many modifications and variations of the invention as hereinbefore set forth can be made without departing from the spirit and scope thereof, and, therefore, only such limitations should be imposed as are indicated by the appended claims.

• [0221] Acetyl Tnoctyl Citrate
• [0222] Apricot Kernel Oil PEG-6 Esters
• [0223] Butyl Acetyl Ricinoleate
• [0224] Butyl Mynstate
• [0225] Butyl Oleate
• [0226] Butyl Stearate
• [0227] C18-36 Acid Glycol Ester
• [0228] C12-15 Alcohols Benzoate
• [0229] C12-15 Alcohols Lactate
• [0230] C12-15 Alcohols Octanoate
• [0231] C15-18 Glycol
• [0232] C18-20 Glycol Isostearate
• [0233] C14-16 Gylcol Palmrtate
• [0234] C11-15 Pareth-3 Oleate
• [0235] C11-15 Pareth-3 Stearate
• [0236] C11-15 Pareth-12 Stearate
• [0237] C12-15 Pareth-9 Hydrogenated Tallowate
• [0238] C12-15 Pareth-12 Oleate
• [0239] Caprylic/Capnc/Diglyceryl Succinate
• [0240] Caprylic/Capnc Glycendes
• [0241] Carpylic/Capnc/Isosteanc/Adipic Triglycendes
  • [0242] Cetyl Acetate
  • [0243] Cetylarachidol
  • [0244] Cocoglycendes
• [0245] Corn Oil PEG-6 Esters
• [0246] Cottonseed Glycende
• [0247] Dibutyl Adipate
• [0248] Dibutyl Sebacate
• [0249] Di-C12-15 Alcohols Adipate
• [0250] Dicapryl Adipate
• [0251] Dicetyl Adipate
• [0252] Diethylene Glycol Dibenzoate
• [0253] Diethyl Palmrtoyl Aspartate
• [0254] Diethyl Sebacate
• [0255] Dihexyl Adipate
• [0256] Dihydrocholesteryl Octyldecanoate
• [0257] Dihydrophytosteryl Octyldecanoate
• [0258] Dihydroxyethyl Soyamine Dioleate
• [0259] Dihydroxyethyl Tallowamine Oleate
• [0260] Diisobutyl Adipate
• [0261] Diisocetyl Adipate
• [0262] Diisodecyl Adipate
• [0263] Diisopropyl Adipate
• [0264] Diisopropyl Diinoleate
• [0265] Diisopropyl Sebacate
• [0266] Dipropylene Glycol Dibenzoate
• [0267] Ditndecyl Adipate
• [0268] Ethyl Arachidonate
• [0269] Ethyl Laurate
• [0270] Ethyl Linoleate
• [0271] Ethyl Linolenate
• [0272] Ethyl Morrhuate
• [0273] Ethyl Mynstate
• [0274] Ethyl Palmrtate
• [0275] Ethyl Pelargonate
• [0276] Ethyl Persate
• [0277] Ethyl Stearate
• [0278] Fish Glycendes
• [0279] Glyceryl Benenate
• [0280] Glyceryl Caprate
• [0281] Glyceryl Caprylate
• [0282] Glyceryl Caprylate/Caprate
• [0283] Glyceryl Cocoate
• [0284] Glyceryl Dilaurate
• [0285] Glyceryl Dioleate
• [0286] Glyceryl Distearate
• [0287] Glyceryl Erucate
• [0288] Glyceryl Hydroxystearate
• [0289] Glyceryl Isostearate
• [0290] Glyceryl Lanolate
• [0291] Glyceryl Laurate
• [0292] Glyceryl Linoleate
• [0293] Glyceryl Mynstate
• [0294] Glyceryl Oleate
• [0295] Glyceryl Palmrtate Lactate
• [0296] Glyceryl Ricinoleate
• [0297] Glyceryl Sesquioleate
• [0298] Glyceryl Stearate
• [0299] Glyceryl Stearate Citrate
• [0300] Glyceryl Stearate Lactate
• [0301] Glyceryl Triacetyl Hydroxystearate
• [0302] Glyceryl Triacetyl Ricinoleate
• [0303] Glyceryl Trioctanoate
• [0304] Glyceryl Triundecanoate
• [0305] Glyceryl Dioctanoate
• [0306] Glyceryl Hydroxystearate
• [0307] Glycol Oleate
• [0308] Glycol Ricinoleate
• [0309] Glycol Stearate
• [0310] Heptylundecanol
• [0311] Hexyl Laurate
• [0312] Hydrogenated Coco-Glycendes
• [0313] Hydrogenated Lard Glycende
• [0314] Hydrogenated Lard Glycendes
• [0315] Hydrogenated Palm Glycendes
• [0316] Hydrogenated Palm Kernal Glycendes
• [0317] Hydrogenated Palm Oil Glycende
• [0318] Hydrogenated Palm Oil Glycendes
• [0319] Hydrogenated Palm/Palm Kernel Oil PEG-6 Esters
• [0320] Hydrogenated Polyisobutene
• [0321] Hydrogenated Soybean Oil Glycendes
• [0322] Hydrogenated Soy Glycende
• [0323] Hydrogenated Tallow Glycende
• [0324] Hydrogenated Tallow Glycende Citrate
• [0325] Hydrogenated Tallow Glycende Lactate
• [0326] Hydrogenated Tallow Glycendes
• [0327] Hydrogenated Tallow Glycendes Citrate
• [0328] Hydrogenated Vegetable Glycende
• [0329] Hydrogenated Vegetable Glycendes
• [0330] Hydrogenated Vegetable Glycendes Phosphate
• [0331] Hydroxylated Lanolin
• [0332] Hydroxyoctacosanyl Hydroxystearate
• [0333] Isoamyl Laurate
• [0334] Isobutyl Mynstate
• [0335] Isobutyl Palmrtate
• [0336] Isobutyl Pelargonate
• [0337] Isobutyl Stearate
• [0338] Isohexyl Laurate
• [0339] Isohexyl Palmrtate
• [0340] Isopropyl Isostearate
• [0341] Isopropyl Lanolate
• [0342] Isopropyl Laurate
• [0343] Isopropyl Linoleate
• [0344] Isopropyl Methoxycinnamate
• [0345] Isopropyl Mynstate
• [0346] Isopropyl Oleate
• [0347] Isopropyl Palmrtate
• [0348] Isopropyl Ricinoleate
• [0349] Isopropyl Stearate
• [0350] Isopropyl Tallowate
• [0351] Isostearyl Alcohol
• [0352] Isostearyl Benzoate
• [0353] Isostearyl Isostearate
• [0354] Isostearyl Lactate
• [0355] Isostearyl Neopentanoate
• [0356] Isostearyl Palmrtate
• [0357] Isotndecyl Isononanoate
• [0358] Laneth-9 Acetate
• [0359] Laneth-10 Acetate
• [0360] Lanolin
• [0361] Lard Glycendes
• [0362] Laureth-2 Benzoate
• [0363] Lauryl Isostearate
• [0364] Lauryl Lactate
• [0365] Methyl Acetyl Ricinoleate
• [0366] Methyl Caproate
• [0367] Methyl Caprylate
• [0368] Methyl Caprylate/Caprate
• [0369] Methyl Cocoate
• [0370] Methyl Dehydroabietate
• [0371] Methyl Glucose Sesquioleate
• [0372] Methyl Glucose Sesquistearate
• [0373] Methyl Hydrogenated Rosinate
• [0374] Methyl Hydroxystearate
• [0375] Methyl Laurate
• [0376] Methyl Linoleate
• [0377] Methyl Mynstate
• [0378] Methyl Oleate
• [0379] Methyl Palmrtate
• [0380] Methyl Pelargonate
• [0381] Methyl Ricinoleate
• [0382] Methyl Rosinate
• [0383] Methyl Stearate
• [0384] Myreth-3 Caprate
• [0385] Myreth-3 Laurate
• [0386] Myreth-3 Mynstate
• [0387] Myreth-3 Palmrtate
• [0388] Neopentyl Glycol Dicaprate
• [0389] Neopenytl Glycol Dioctanoate
• [0390] Nonyl Acetate
• [0391] Octyl Acetoxystearate
• [0392] Octyldodecyl Neodecanoate
• [0393] Octyl Hydroxystearate
• [0394] Octyl Isononanoate
• [0395] Palm Kernel Glycendes
• [0396] Palm Oil Glycendes
• [0397] PEG-6 Caprylic/Capnc Glycendes
• [0398] PEG-2 Castor Oil
• [0399] PEG-3 Castor Oil
• [0400] PEG-4 Castor Oil
• [0401] PEG-5 Castor Oil
• [0402] PEG-8 Castor Oil
• [0403] PEG-9 Castor Oil
• [0404] PEG-10 Castor Oil
• [0405] PEG-10 Coconut Oil Esters
• [0406] PEG-5 Glyceryl Trisostearate
• [0407] PEG-5 Hydrogenated Castor Oil
• [0408] PEG-7 Hydrogenated Castor Oil
• [0409] PEG-5 Hydrogenated Corn Glycendes
• [0410] PEG-5 Hydrogenated Fish Glycendes
• [0411] PEG-20 Methyl Glucose Sesquinstearate
• [0412] Pentaerythntyl Rosinate
• [0413] Pentaerythntyl Tetraoctanoate
• [0414] Pentaerythntyl Tetraoleate
• [0415] PPG-4-Ceteth-1
• [0416] PPG-8-Ceteth-1
• [0417] PPG-8-Ceteth-2
• [0418] PPG-10 Cetyl Ether
• [0419] PPG-10 Cetyl Ether Phosphate
• [0420] PPG-28 Cetyl Ether
• [0421] PPG-30 Cetyl Ether
• [0422] PPG-50 Cetyl Ether
• [0423] PPG-17 Dioleate
• [0424] PPG-3 Hydrogenated Castor Oil
• [0425] PPG-30 Isocetyl Ether
• [0426] PPG-5 Lanolate
• [0427] PPG-2 Lanolin Alcohol Ether
• [0428] PPG-5 Lanolin Alcohol Ether
• [0429] PPG-10 Lanolin Alcohol Ether
• [0430] PPG-20 Lanolin Alcohol Ether
• [0431] PPG-30 Lanolin Alcohol Ether
• [0432] PPG-5 Lanolin Wax
• [0433] PPG-5 Lanolin Wax Glcende
• [0434] PPG-9 Laurate
• [0435] PPG-4 Lauryl Ether
• [0436] PPG-3 Mynstyl Ether
• [0437] PPG-4 Mynstyl Ether
• [0438] PPG-26 Oleate
• [0439] PPG-36 Oleate
• [0440] PPG-10 Oleyl Ether
• [0441] PPG-20 Oleyl Ether
• [0442] PPG-23 Oleyl Ether
• [0443] PPG-30 Oleyl Ether
• [0444] PPG-37 Oleyl Ether
• [0445] PPG-50 Oleyl Ether
• [0446] PPG-9-Steareth-3
• [0447] PPG-11 Stearyl Ether
• [0448] PPG-15 Stearyl Ether
• [0449] Propylene Glycol Isostearate
• [0450] Propylene Glycol Hydroxystearate
• [0451] Propylene Glycol Laurate
• [0452] Propylene Glycol Mynstate
• [0453] Propylene Glycol Mynstyl Ether
• [0454] Propylene Glycol Mynstyl Ether Acetate
• [0455] Propylene Glycol Oleate
• [0456] Propylene Glycol Ricinoleate
• [0457] Propylene Glycol Soyate
• [0458] Propylene Glycol Stearate
• [0459] Soy Sterol
• [0460] Soy Sterol Acetate
• [0461] Squalene
• [0462] Stearoxytnmethylsriane
• [0463] Sucrose Distearate
• [0464] Suffunzed Jojoba Oil
• [0465] Sunflower Seed Oil Glycendes
• [0466] Tall Oil Glycendes
• [0467] Tallow Glycende
• [0468] Tallow Glycendes
• [0469] Trisocetyl Citrate
• [0470] Trisosteann PEG-6 Esters
• [0471] Trimethylsilylamodimethicone
• [0472] Triolein PEG-6 Esters
• [0473] Tris(Tributoxysiloxy)Methylsilane
• [0474] Vegetable Glycendes Phosphate
• [0475] Wheat Germ Glycendes
• [0476] Adenosine Phosphate
• [0477] Adenosine Triphosphate
• [0478] Alanine
• [0479] Aldioxa
• [0480] Allantoin Ascorbate
• [0481] Allantoin Biotin
• [0482] Allantoin Calcium Pantothenate
• [0483] Allantoin Galacturonic Acid
• [0484] Allantoin Glycyrrhetinic Acid
• [0485] Allantoin Polygalacturonic acid
• [0486] Aloe
• [0487] Animal Collagen Amino Acids
• [0488] Animal Elastin Amino Acids
• [0489] Animal Keratin Amino Acids
• [0490] Arginine
• [0491] Asparagine
• [0492] Aspartic Acid
• [0493] Camphor
• [0494] Caprylyl/Capryl Glucoside
• [0495] Casein
• [0496] Cetyl Cetaine
• [0497] Chlorodeceth-14
• [0498] Cholesterol
• [0499] Cocamidopropyl Lauryl Ether
• [0500] Cysteine
• [0501] Cysteine HCl
• [0502] Cystine
• [0503] Desamido Animal Collagen
• [0504] Dicaprytoyl Cystine
• [0505] Diethyl Aspartate
• [0506] Diethylene Tricaseinamide
• [0507] Diethyl Glutamate
• [0508] Dihydrocholesterol
• [0509] Dipalmitoyl Hydroxyproline
• [0510] Disodium Adenosine Triphosphate
• [0511] Ethyl Aspartate
• [0512] Ethyl Ester of Hydrolyzed Animal Protein
• [0513] Ethyl Glutamate
• [0514] Ethyl Sennate
• [0515] Ethyl Urocanate
• [0516] Folic Acid
• [0517] Frutose
• [0518] Glutamic Acid
• [0519] Glutamine
• [0520] Glyceryl Lanolate
• [0521] Glycine
• [0522] Glycogen
• [0523] Guanosine
• [0524] Hexamethyldisiloxane
• [0525] Hexyl Nicotinate
• [0526] Histidine
• [0527] Human Placental Protein
• [0528] Hyaluronic Acid
• [0529] Hydrogenated Animal Glycende
• [0530] Hydrogenated Laneth-5
• [0531] Hydrolyzed Animal Elastin
• [0532] Hydrolyzed Animal Keratin
• [0533] Hydrolyzed Animal Protein
• [0534] Hydrolyzed Casein
• [0535] Hydrolyzed Human Placental Protein
• [0536] Hydrolyzed Mucopolysacchandes
• [0537] Hydrolyzed Silk
• [0538] Hydrolyzed Soy Protein
• [0539] Hydrolyzed Vegetable Protein
• [0540] Hydrolyzed Yeast Protein
• [0541] Hydrolyzed Lanolin
• [0542] Hydroxyproine
• [0543] Isoleucine
• [0544] Keratin
• [0545] Laneth-4 Phosphate
• [0546] Laneth-5
• [0547] Lanolinamide DEA
• [0548] Lanosterol
• [0549] Lard Glycendes
• [0550] Lauramidopropyl Betaine
• [0551] Lauryl Aminopropylglycine
• [0552] Lauryl Diethylenediaminoglycine
• [0553] Lecithin
• [0554] Leucine
• [0555] Lysine
• [0556] Magnesium Aspartate
• [0557] Magnesium Lanolate
• [0558] MEA-Hydrolyzed Animal Protein
• [0559] Methionine
• [0560] 2-Methyl-4-Hydroxypyrrolidine
• [0561] Milk
• [0562] Mixed Isopropanolamines Lanolate
• [0563] Mixed Mucopolysacchandes
• [0564] Monosacchande Lactate Condons
• [0565] Niacinamide
• [0566] Norvaine
• [0567] Oleyl Betane
• [0568] θrotic Acid
• [0569] Palmitoyl Animal Collagen Amino Acids
• [0570] PEG-5 Hydrogenated Lanolin
• [0571] PEG-10 Hydrogenated Lanolin
• [0572] PEG-2 Milk Solids
• [0573] PEG-6 Soya Sterol Undecylenate
• [0574] Phenytalanine
• [0575] Polyglyceryl-2 Lanolin Alcohol Ether
• [0576] Potassium Aspartate
• [0577] Potassium Caseinate
• [0578] Potassium DNA
• [0579] PPG-2Buteth-3
• [0580] PPG-3Buteth-5
• [0581] PPG-5Buteth-7
• [0582] PPG-7Buteth-10
• [0583] PPG-9Buteth-12
• [0584] PPG-12Buteth-16
• [0585] PPG-15Buteth-20
• [0586] PPG-20Buteth-30
• [0587] PPG-24Buteth-27
• [0588] PPG-25Buteth-26
• [0589] PPG-28Buteth-35
• [0590] PPG-33Buteth-45
• [0591] PPG-4 Butyl Ether
• [0592] PPG-5 Butyl Ether
• [0593] PPG-9 Butyl Ether
• [0594] PPG-14 Butyl Ether
• [0595] PPG-15 Butyl Ether
• [0596] PPG-16 Butyl Ether
• [0597] PPG-18 Butyl Ether
• [0598] PPG-22 Butyl Ether
• [0599] PPG-24 Butyl Ether
• [0600] PPG-30 Butyl Ether
• [0601] PPG-33 Butyl Ether
• [0602] PPG-40 Butyl Ether
• [0603] PPG-53 Butyl Ether
• [0604] PPG-2 Isostearate
• [0605] PPG-10 Methyl Glucose Ether
• [0606] PPG-20 Methyl Glucose Ether
• [0607] PPG-20 Methyl Glucose Ether Acetat
• [0608] PPG-2 Mynstyl Ether Propionate
• [0609] Pregnenolone Acetate
• [0610] Proline
• [0611] Pyndoxine
• [0612] Pyndoxine Dicaprylate
• [0613] Pyndoxine Dilaurate
• [0614] Pyndoxine Dioctenoate
• [0615] Pyndoxine Dipalmitate
• [0616] Pyndoxine HCl
• [0617] Pyndoxine Tripalmitate
• [0618] Resorcinol Acetate
• [0619] Retnol
• [0620] Retinyl Acetate
• [0621] Retinyl Palmrtate
• [0622] Ribonucleic Acid
• [0623] Ricinoleamidopropyl Betaine
• [0624] Salicylic Acid
• [0625] Senine
• [0626] Serum Albumin
• [0627] Serum Proteins
• [0628] Silk Amino Acids
• [0629] Sodium Caseinate
• [0630] Sodium Chondroitin Sulfate
• [0631] Sodium DNA
• [0632] Sodium Gluconate
• [0633] Sodium Glutamate
• [0634] Sodium Hyaluronate
• [0635] Sodium Lactate Methylsilanol
• [0636] Sodium Laneth Sulfate
• [0637] Sodium Mannuronate Methylsilanol
• [0638] Sodium PCA Methylsilanol
• [0639] Sodium Riboflavin Phosphate
• [0640] Sodium Urocanate
• [0641] Soluble Animal Collagen
• [0642] Sorbitol
• [0643] Soyaethyl Morpholinium Ethosulfate
• [0644] Soy Protein
• [0645] Sulfunzed Jojoba Oil
• [0646] Tall Oil Sterol
• [0647] Thiamine HCl
• [0648] Thiamine Nitrate
• [0649] Threonine
• [0650] Tocopheryl Acetate
• [0651] Tocopheryl Linoleate
• [0652] Tocopheryl Nicotinate
• [0653] Tocopheryl Succinate
• [0654] Tocopheryl Salicytate
• [0655] Tridecyl Salicylate
• [0656] Tridecyl Stearate
• [0657] Tryptophan
• [0658] Tyrosine
• [0659] Unc Acid
• [0660] Urocanic Acid
• [0661] Wheat Germamidopropyl Dimethylamine Lactate
• [0662] Whey Protein
• [0663] Octylacrylamide/Acrylates/Butylaminoethyl Methacrylate Copolymer
• [0664] Octylacrylamide/Acrylates Copolymer
• [0665] PEG-22/Dodecyl Glycol Copolymer
• [0666] PEG-45/Dodecyl Glycol Copolymer
• [0667] PEI-7
• [0668] PEI-15
• [0669] PEI-30
• [0670] PEI-45
• [0671] PEI-275
• [0672] PEI-700
• [0673] PEI-1000
• [0674] PEI-1500
• [0675] PEI-2500
• [0676] Polyacrylamide
• [0677] Polyacrylamidomethylpropane Sulfonic Acid
• [0678] Polyacrylic Acid
• [0679] Polyaminopropyl Biguanide
• [0680] Polyamino Sugar Condensate
• [0681] Polyquaternium-1
• [0682] Polyquaternium-2
• [0683] Polyquaternium-4
• [0684] Polyquaternium-5
• [0685] Polyquaternium-6
• [0686] Polyquaternium-7
• [0687] Polyquaternium-8
• [0688] Polyquaternium-9
• [0689] Polyquaternium-10
• [0690] Polyquaternium-11
• [0691] Polyquaternium-12
• [0692] Polyquaternium-13
• [0693] Polyquaternium-14
• [0694] Polyquaternium-15
• [0695] Polyvinyl Alcohol
• [0696] Polyvinyl Butyral
• [0697] Polyvinyl Imidazolinium Acetate
• [0698] Polyvinyl Laurate
• [0699] Polyvinyl Methyl Ether
• [0700] PVM/MA Copolymer
• [0701] PVP
• [0702] PVP/Dimethylaminoethylmethacrylate Copolymer
• [0703] PVP/Ethyl Methacrylate/Methacrylic Acid Copolymer
• [0704] PVP/Hexadecene Copolymer
• [0705] Sodium Polystyrene Sulfonate
• [0706] Sodium Styrene/Acrylate/PEG-10 Dimaleate Copolymer
• [0707] Starch/Acrylates/Acrylamide Copolymer
• [0708] Stearylvinyl Ether/Maleic Anhydride Copolymer
• [0709] Styrene/PVP Colpolymer
• [0710] Sucrose Benzoate/Sucrose Acetate Isobutyrate/Butyl Benzyl Phthalate Copolymer
• [0711] Sucrose Benzoate/Sucrose Acetate Isobutyrate/Butyl Benzyl Phthalate/Methyl Methcrylate Copolymer
• [0712] Sucrose Benzoate/Sucrose Acetate Isobutyrate Coploymer
• [0713] Meroxapol 105
• [0714] Meroxapol 108
• [0715] Meroxapol 171
• [0716] Meroxapol 172
• [0717] Meroxapol 174
• [0718] Meroxapol 178
• [0719] Meroxapol 251
• [0720] Meroxapol 252
• [0721] Meroxapol 254
• [0722] Meroxapol 255
• [0723] Meroxapol 258
• [0724] Meroxapol 311
• [0725] Meroxapol 312
• [0726] Meroxapol 314
• [0727] PEG-4
• [0728] PEG-6
• [0729] PEG-8
• [0730] PEG-9
• [0731] PEG-10
• [0732] PEG-12
• [0733] PEG-14
• [0734] PEG-16
• [0735] PEG-18
• [0736] PEG-20
• [0737] PEG-32
• [0738] PEG-40
• [0739] PEG-6-32
• [0740] PEG-75
• [0741] PEG-135
• [0742] PEG-150
• [0743] PEG-200
• [0744] PEG-350
• [0745] PEG-2M
• [0746] PEG-5M
• [0747] PEG-7M
• [0748] PEG-9M
• [0749] PEG-14M
• [0750] PEG-20M
• [0751] PEG-23M
• [0752] PEG-45M
• [0753] PEG-90M
• [0754] PEG-115M
• [0755] PEG/PPG-17/6 Copolymer
• [0756] PEG/PPG-18/4 Copolymer
• [0757] PEG/PPG-23/50 Copolymer
• [0758] PEG/PPG-35/9 Copolymer
• [0759] PEG/PPG-125/30 Copolymer
• [0760] Poloxamer 101
• [0761] Poloxamer 105
• [0762] Poloxamer 108
• [0763] Poloxamer 122
• [0764] Poloxamer 123
• [0765] Poloxamer 124
• [0766] Poloxamer 181
• [0767] Poloxamer 182
• [0768] Poloxamer 183
• [0769] Poloxamer 184
• [0770] Poloxamer 185
• [0771] Poloxamer 188
• [0772] Poloxamer 212
• [0773] Poloxamer 215
• [0774] Poloxamer 217
• [0775] Poloxamer 231
• [0776] Poloxamer 234
• [0777] Poloxamer 235
• [0778] Poloxamer 237
• [0779] Poloxamer 238
• [0780] Poloxamer 282
• [0781] Poloxamer 284
• [0782] Poloxamer 288
• [0783] Poloxamer 331
• [0784] Poloxamer 333
• [0785] Poloxamer 334
• [0786] Poloxamer 335
• [0787] Poloxamer 338
• [0788] Poloxamer 401
• [0789] Poloxamer 402
• [0790] Poloxamer 403
• [0791] Poloxamer 407
• [0792] PPG-9
• [0793] PPG-12
• [0794] PPG-15
• [0795] PPG-17
• [0796] PPG-20
• [0797] PPG-26
• [0798] PPG-30
• [0799] PPG-34
• [0800] Acacia
• [0801] Agar
• [0802] Algin
• [0803] Alginic Acid
• [0804] Ammonium Alginate
• [0805] Calcium Alginate
• [0806] Calcium Carrageenan
• [0807] Callulose Gum
• [0808] Damar
• [0809] Dextran
• [0810] Dextrin
• [0811] Carboxymethyl Hydroxyethylcellulose
• [0812] Carboxymethyl Hydroxypropyl Guar
• [0813] Carrageenan
• [0814] Ethylcellulose
• [0815] Gelatin
• [0816] Guar Gum
• [0817] Guar Hydroxypropyltnmonium Chloride
• [0818] Gum Benzoin
• [0819] Hydroxybutyl Methylcellulose
• [0820] Hydroxyethylcellulose
• [0821] Hydroxyethyl Ethylcellulose
• [0822] Hydroxypropylcellulose
• [0823] Hydroxypropyl Guar
• [0824] Hydroxypropyl Methylcellulose
• [0825] Jalap Resin
• [0826] Karaya Gum
• [0827] Kelp
• [0828] Locust Bean Gum
• [0829] Maltodextnn
• [0830] Methylcellulose
• [0831] Ollbanum
• [0832] Pectin
• [0833] Potassium Alginate
• [0834] Potassium Carrageenan
• [0835] Propylene Glycol Alginate
• [0836] Sandarac Gum
• [0837] Sodium Carboxymethyl Dextran
• [0838] Sodium Carrageenan
• [0839] Sodium Cellulose Sulfate
• [0840] Tragacanth Gum
• [0841] Xanthan Gum
• [0842] Acrylamides Copolymer
• [0843] Acrylamide/Sodium Acrylate Copolymer
• [0844] Acrylate/Acrylamide Copolymer
• [0845] Acrylate/Ammonium Methacrylate Copolymer
• [0846] Acrylates Copolymer
• [0847] Acrylates/Diacetoneacrylamide Copolymer
• [0848] Acrylates/Steareth-20 Methacrylate Copolymer
• [0849] Acrylic/Acrylate Copolymer
• [0850] Adipic Acid/Dimethylaminohydroxypropyl Diethylenetnamine Copolymer
• [0851] Adipic Acid/Epoxypropyl Diethylenetnamine Copolymer
• [0852] Allyl Stearate/VA Copolymer
• [0853] Aminoethylacrylate Phosphate/Acrytate Copolymer
• [0854] Ammonium Acrylates Copolymer
• [0855] Ammonium Styrene/Acrylate Copolymer
• [0856] Ammonium Vinyl Acetate/Acrylates Copolymer
• [0857] AMP Acrylates/Diacetoneacrylamide Copolymer
• [0858] AMPD Acrylates/Diacetoneacrylamide Copolymer
• [0859] Benzoic Acid/Phthalic Anhydride/Pentaerythntol/Neopentyl Glycol/Palmitic Acid Copolymer
• [0860] Carbomer 910
• [0861] Carbomer 934
• [0862] Carbomer 934P
• [0863] Carbomer 940
• [0864] Carbomer 941
• [0865] Corn Starch/Acrylamide/Sodium Acrylate Copolymer
• [0866] DEA-Styrene/Acrylates/Divinylbenzene Copolymer
• [0867] Diethylene Glycolamine/Epichlorohydrin/Piperazine Copolymer
• [0868] Dodecanedioic Acid/Cetearyl Alcohol/Glycol Copolymer
• [0869] Ethylene Acrylate Copolymer
• [0870] Hydroxyethyl PEI-1000
• [0871] Hydroxyethyl PEI-1500
• [0872] Isobutylene/Maleic Anhydride Copolymer
• [0873] Isopropyl Ester of PVM/MA Copolymer
• [0874] Methacryloyl Ethyl Bentaine/Methacrylates Copolymer
• [0875] Methoxy PEG-22/Dodecyl Glycol Copolymer