Liquid atomizer

[0001] This application claims priority on Japanese patent application 2003-82226 filed Mar. 25, 2003.

[0002] This invention relates to a liquid atomizer and more particularly to a liquid atomizer of the kind structured such that a plurality of ampoules each containing a prescribed quantity of liquid medicament or the like can be mounted to a main device.

[0003] For a liquid atomizer of the kind for treating a patient by causing the patient to breathe in an atomized liquid medicament, it is important to accurately measure up and administer the prescribed quantity of medicament for each time of use. For this purpose, the patient himself/herself is often required to fill specified containers each with a specified quantity of the medicament. The work of thus preparing individual doses of medicament is a very cumbersome task, and the likelihood of an error that may be committed by the user must not be ignored. Liquid atomizers for such a purpose, furthermore, must be easily portable such that a treatment can be started immediately when, for example, the user experiences a sudden fit while being out of the house.

[0004] In view of the above, Japanese Patent Publication Tokuhyo 8-502689 disclosed a device adapted to make the work of the user easier by allowing ampoules preliminarily filled with a specified amount of medicament to be set on a liquid atomizer at the time of the use such that an accurately measured quantity of medicament can be administered.

[0005] A device thus structured, however, is not easily portable because the ampoules containing a liquid medicament are adapted to be delivered along a straight line and the area for containing these ampoules becomes large.

[0006] It is therefore an object of this invention in view of this problem of the prior art device to provide a liquid atomizer that can be made compact by reducing the size of the space required for containing ampoules.

[0007] A liquid atomizer according to this invention is for atomizing a liquid and may be characterized as comprising a main body with an atomizing part for atomizing the liquid discharged from outlets of ampoules which contain the liquid and an ampoule holder for holding the ampoules in an annular formation and allowing the outlet of each of these ampoules to be disposed proximal to the atomizing part by rotating the annular formation of the ampoules. Since the plurality of ampoules are held in an annular formation according to this invention, the space for containing the ampoules can be made compact and this means that a relatively small space is enough to contain many ampoules. As a result, the ampoule holder serving as means for holding the ampoules can be made compact.

[0008] It is preferable to attach the ampoule holder detachably to the main body. In this manner, a plurality of ampoules can be set to the main body all at once by preliminarily causing the ampoule holder to hold a plurality of ampoules and, when the liquid in all of the ampoules held by the ampoule holder has been used up, the ampoules can be removed all at once from the main body together with the ampoule holder and it may be replaced by another ampoule holder holding another set of ampoules filled with a liquid. In this manner, used-up ampoules can be easily disposed of without getting scattered around.

[0009] It is further preferable to have positioning means provided between the main body and the ampoule holder for positioning the ampoule holder with respect to the main body. With such positioning means, the starting positions of the ampoules are uniquely determined and hence their final positions are also uniquely determined. Thus, it becomes possible to easily estimate how soon the ampoule holder should be replaced by a new one holding ampoules that are filled.

[0010] It is still further preferable that the ampoule holder hold the ampoules such that each ampoule can be moved between one position (the advanced position) at which the outlet of the ampoule moves into the atomizing part and another position (the retracted position). When each of the ampoules is at the retracted position, the ampoule holder can undergo a rotary motion with respect to the main body. An elongated member, hereafter referred to as the arm, may preferably be used as means for causing each of the ampoules between the advanced and retracted positions.

[0032] The invention will be described next by way of examples. A medicament liquid atomizer for atomizing a liquid medicament, say, for treating an asthma patient will be described but it is to be reminded that the present invention is not intended to be limited to liquid medicament atomizers but is applicable widely to liquid atomizers of all kinds adapted to atomize a liquid.

[0033] FIGS. 1-6 are referenced first to describe the overall structure of a medicament liquid atomizer (hereinafter referred to simply as the atomizer) 100 embodying this invention. FIG. 1 is its diagonal external view, FIG. 2 is its plan view, FIG. 3 is its sectional view taken along line XVIII—XVIII of FIG. 2, FIG. 4 is its partially exploded view, FIG. 5 is an enlarged diagonal view of a portion thereof, and FIG. 6 is an enlarged diagonal view of its rotary ampoule-holding member (herein referred to as the rotary member 130).

[0034] As shown in FIG. 1, the atomizer 100 is comprised of a main frame 102 provided with an atomizing part 104 and an ampoule holder 101 serving as an ampoule holding means disposed near the atomizing part 104 for holding a plurality of ampoules 200 for supplying a medicament liquid to the atomizing part 104. The ampoules 200 are held in an annular formation. As the ampoule holder 101 causes the annular formation of the ampoules 200 while holding the ampoules 200 in the annular formation, the outlets of the individual ampoules 200 can be brought sequentially to a position proximal to the atomizing part 104.

[0035] An elongated member (hereinafter referred to as the arm 150) is provided on the upper surface of the atomizer 100 for moving each of the ampoules 200 held by the ampoule holder 101 from a retracted position towards the atomizing part 104 and to an advanced position.

[0036] As shown in FIG. 3, a control unit 160 for controlling the atomizing part 104 is contained inside the atomizer 100. A connector opening 110 for inserting the outlet (to be described below) of an ampoule 200 is provided near the atomizing part 104. On the side of the front surface of the atomizer 100 is a holder base 120 for detachably connecting the ampoule holder 101 to the main frame 102. As more clearly shown in FIGS. 4 and 5, the holder base 120 is comprised of a circular base 121, an outer guide 122 which surrounds the circular base 121, an inner guide 123 provided inside the outer guide 122 and a support shaft 124 extending perpendicularly to the front surface of the main frame 102 from the center of the holder base 120. The support shaft 124 is provided with a hook 125 for engaging with a slidable shaft 145 of an ampoule cover (or “the cover 140”, to be described below).

[0037] The structure of the ampoule holder 101 is described next.

[0038] As explained above, the holder base 120 is provided on the side of the front surface of the atomizer 100 to which the ampoule holder 101 is mounted. As shown in FIGS. 5 and 6, a rotary member 130 is provided detachably to the holder base 120. This rotary member 130 is comprised of a tubular base 131, support arms 132 which extend radially from the outer peripheral surface of this tubular base 131, and ampoule holding members (hereinafter “holding members”) 134 which are each connected to the tip of a corresponding one of the support arms 132 and disposed in an annular formation.

[0039] The rotary member 130 is mounted to the holder base 120 such that the support shaft 124 penetrates the interior of the tubular base 131 and is arranged such that the holding members 134 will rotate as a whole around the support shaft 124 and the outer peripheral surface of the tubular base 131 will slide along the inner surface of the inner guide 123. An opening 133 is provided on the outer peripheral surface of each holding member 134 and a pair of positioning side walls 135 is provided on the outer peripheral surface abutting this opening 133. Although the rotary member 130 is shown with ten holding members 134, the number of the holding members 134 is not intended to limit the scope of the invention. The number of the holding members 134 on the rotary member 130 may be varied according to the needs.

[0040] In summary, since the holding members 134 are arranged such that a plurality of ampoules 200 are held in an annular formation, the ampoules 200 can be contained within a relatively small space and a compact atomizer holding many ampoules 200 can be realized according to this invention. Moreover, since a plurality of ampoules 200 can be preliminarily set in the rotary member 130, a plurality of ampoules 200 can be easily set at once on the holder base 120. After medicament liquid from all of the ampoules 200 has been used up, the entire rotary member 130 can be removed from the holder base 120 and another rotary member 130 carrying new ampoules 200 filled with a medicament liquid may be set to the holder base 120 such that the used ampoules 200 can be disposed of neatly and efficiently without getting scattered.

[0041] The structure of the ampoule 200 is described next with reference to FIGS. 7-11. FIG. 7 is a diagonal external view of an ampoule main body 201 before injection, FIG. 8 is a diagonal external view of an ampoule after injection, FIG. 9 is a sectional view taken along line IX—IX of FIG. 8 before injection, FIG. 10 is a sectional view taken along line IX—IX of FIG. 8 after injection and FIG. 11 (consisting of FIGS. 11A, 11B and 11C) is for schematically showing the functions of the ampoule main body 201.

[0042] As shown in FIGS. 7 and 8, the ampoule 200 is provided with the ampoule main body 201 and a cover member 230 attached to the ampoule main body 201. The ampoule main body 201 is provided with a longitudinally elongated rib 201a on its outer surface and the cover member 230 is provided with a key groove 233 on its inner surface so as to engage with the rib 201a. The rib 201a on the ampoule main body 201 and the key groove 233 on the cover member 230 together serve as a positioning means (hereinafter also referred to as the first positioning means) for dependably positioning the cover member 230 with respect to the ampoule main body 201.

[0043] The cover member 230 is also provided with a pair of longitudinally elongated ribs (the first ribs) 231 on its outer peripheral surface such that they will engage with the aforementioned positioning side walls 135 when the ampoule 200 is inserted into the corresponding one of the holding members 134. Thus, the first ribs 230 and the positioning side walls 135 serve as another positioning means (hereinafter also referred to as the second positioning means) for dependably positioning the ampoule main body 134 with respect to the cover member 230.

[0044] By way of the engaging relationships described above, the ampoules 200 are capable of sliding longitudinally with respect to the holding members 134 while the ampoule main bodies 201 are prevented from rotating around themselves with respect to the holding members 134. The cover member 230 is also provided with a circumferentially extending rib (the second rib) 232 on its outer peripheral surface at a backward position so as to engage with the arm 150, as will be explained more in detail below.

[0045] The structure of the ampoule main body 201 is described next with reference to FIGS. 9 and 10.

[0046] The purpose of this ampoule main body 201 is to contain a specified amount (such as about 20 microliters) of a medicament liquid 240 inside. Thus, the ampoule main body 201 comprises an approximately tubular part 201Z having an open part (the first open part 201X) with an outlet 201h at one end and another open part (the second open part 201Y) at the other end.

[0047] On the side of the first open part 201X of the tubular part 201Z, there is a piston (the first piston 210) that is inserted into the tubular part 201Z in an airtight manner so as to be slidable in the axial direction of the tubular part 201Z. On the side of the second open part 201Y of the tubular part 201Z, there is another piston (the second piston 220) that is inserted into the tubular part 201Z in an airtight manner so as to be slidable in the axial direction of the tubular part 201Z and to form a reservoir 201k for a medicament liquid 240 between the first piston 210. The first piston 210 is provided so as to cover a tubular portion 211a contacting the inner peripheral surface of the tubular part 201Z and the side of this tubular portion 211a facing the reservoir 201k and includes a weakened part 211b comprising a membrane that is thinner than the average thickness of the tubular portion 211a. The second piston 220 is provided with a needle-like sharp part 221 extending towards the first piston 210.

[0048] On the side of the first open part 201X, the tubular part 201Z is provided with a guide groove 202 that extends towards the front and has a cut surface opening in the upward direction. There is also provided a guide tube 203 that forms a passage 201j extending from the side of the first open part 201X towards the first piston 210. Pins 234 are provided inside the cover member 230 for allowing the second piston 220 to slide toward the first piston 210.

[0049] If the reservoir 201k is intended to contain 20 microliters of a medicament liquid, as described above, the total length (L1) of the ampoule 200 may be 19.4 mm, the length of the cover member 230 may be 8.6 mm, and the outer diameter (ØW) of the cover member 230 may be 6.3 mm.

[0050] If the cover member 230 of the ampoule 200 thus structured is moved in the direction of the first open part 201X, the needle-like sharp part 221 penetrates the weakened part 211b of the first piston 210 such that the reservoir 201k and the passage 201j become connected to each other and it becomes possible to discharge the medicament liquid 240 out of the reservoir 201k. An outlet 201h is formed integrally at one end of the tubular part 201Z.

[0051] FIG. 11 shows how the ampoule main body 201 of this invention can be filled with the medicament liquid 240. To start, the first piston 210 is inserted from one end of the tubular part 201Z, as shown in FIG. 11A. Thereafter, the medicament liquid 240 is poured in to fill the other side of the first piston 210, as shown in FIG. 11B. Still thereafter, the second piston 220 is inserted from the other end of the tubular part 201Z, as shown in FIG. 11C. Because of the pressure accompanying the insertion of the second piston 220, both the medicament liquid 240 and the first piston 210 are moved slidingly inside the tubular part 201Z. In this manner, the medicament liquid 240 can be stored inside the tubular part 201Z without allowing hardly any air inside the reservoir 201k even under the atmospheric condition.

[0052] The structure of the cover 140 is described next. As shown in FIG. 4, the cover 140 is comprised of a tubular main body 141 with a window 142 on its side surface. The window 142 is formed with a first window part 142a extending in the axial direction and a second window part 142b extending in the circumferential direction. The tubular main body 141 is provided at its center part with an inward indentation 144, containing therein an unlocking tube 143 so as to be slidable in the axial direction without becoming separated from the indentation 144.

[0053] The function of this unlocking tube 143 is described next with reference to FIG. 18 which is an enlarged sectional view taken along line XVIII—XVIII of FIG. 2, showing only relevant components.

[0054] Under the condition where the rotary member 130 and the cover 140 are attached, the rotary member 130 is pressed by the cover 140 in the direction of the holder base 120, and the cover 140 is affixed to the support shaft 124 as the hook 125 on the support shaft 124 engages with an engagement area 145h provided on the slidable shaft 145 of the ampoule cover 140. Under this condition, the cover 140 is pressed in the direction of the holder base 120 such that the rotary member 130 is pressed towards the holder base 120 by the hook 125. Thus, the rotary member 130 and the cover 140 become affixed to the holder base 120.

[0055] When it is desired to disengage the rotary member 130 from the cover 140, the unlocking tube 143 is inserted in the direction of the holder base 120 (indicated by arrow P in FIG. 18). As a result, the hook 125 is received inside the slidable shaft 145, and the rotary member 130 and the cover 140 are released from the compressive force onto the holder base 120 by the hook 125. Thus, it becomes possible to remove the rotary member 130 and the cover 140.

[0056] The rotary mechanism of the ampoule holder 101 is described next with reference to FIG. 12 which is a sectional view taken along line XII—XII of FIG. 2.

[0057] The inner guide 123 of the holder base 120 is formed as a combination of two nearly semicircular side walls 123a, one of which being wider than the other. Each of these nearly semicircular side walls 123a is provided with an inwardly protruding ratchet hook 123b or 123c at one end thereof. Since the two side walls 123a are of different widths, neither of the ratchet hooks 123b and 123c is on the straight line connecting the other of the ratchet hooks 123b and 123c and the center of rotation of the ampoule holder 101.

[0058] As shown in FIG. 6, furthermore, a plurality of grooves 131a (“the first ratchet grooves”) are provided at a specified pitch on the outer peripheral surface of the tubular base 131 of the rotary member 130 adapted to slide along the inner surface of the inner guide 123. Thus, the relationship between the inner guide 123 and the rotary member 130 is such that the rotary member 130 can be rotated in the counter-clockwise direction (hereinafter always as seen from the front side of the rotary member 130 and indicated by arrow C) and that it is prevented from rotating in the clockwise direction (as indicated by arrow D in FIG. 12) because of the directional relationship between the ratchet hooks 123b and 123c and the first ratchet grooves 131a as shown in FIG. 12.

[0059] FIG. 6 shows that a plurality of grooves 131c (“the second ratchet grooves”) are provided also on the inner peripheral surface of the tubular base 131 at a specified pitch. As shown in FIG. 12, two ratchet hooks 145a are provided on the outer peripheral surface of the slidable shaft 145 of the cover 140. Thus, the relationship between the rotary member 130 and the cover 140 is such that they can rotate together as a single unit in the counter-clockwise direction indicated by arrow C by the engagement between the ratchet hooks 145a and the aforementioned second ratchet grooves 131c but that only the cover 140 can be rotated in the clockwise direction indicated by arrow D because the rotary member 130 is prevented from rotating by means of the inner guide 123.

[0060] The numbers of the first and second ratchet grooves 131a and 131c are determined according to the number of the holding members 134. In the example described herein, therefore, there are ten first ratchet grooves 131a and ten second ratchet grooves 131c.

[0061] The rotary motion of the holding members 134 controlled by the relationship among the inner guide 123, the tubular base 131 and the cover 140 is described next.

[0062] As a first step, the cover 140 is rotated in the counter-clockwise direction by one pitch of the first ratchet grooves 131a. As a result, both the cover 140 and the rotary member 130 rotate simultaneously together by one pitch, transporting one of the holding members 134 on the rotary member 130. Next, as a second step, the cover 140 is rotated in the clockwise direction by one pitch of the second ratchet grooves 131c. Since the rotary member 130 is prevented from rotating in the clockwise direction, it is only the cover 140 that rotates in the clockwise direction by one pitch. Thus, if the first and second steps are sequentially carried out, the holding members 134 are each advanced to the position of the next one.

[0063] As shown in FIG. 12, the outer peripheral surface of the tubular base 131 is provided with a positioning groove 131b as means for positioning the rotary member 130 with respect to the holder base 120. This positioning groove 131b is provided at a specified position such that the ratchet hook 123b can be inserted where the ratchet hook 123c engages with the first ratchet groove 131a. Thus, the position for mounting the rotary member 130 with respect to the ratchet hook 123b is uniquely determined. In other words, the initial position at the start of using the ampoules 200 can be uniquely determined.

[0064] FIG. 12 shows that the outer peripheral surface of the tubular base 131 is further provided with an indentation (“the final position indicating indentation”) 131d. As the rotary member 130 is sequentially rotated in the counter-clockwise direction from its initial position (where the use of the ampoules 200 is started) and after the last of the ampoules 200 has been used up, if the rotary member 130 is further rotated, the ratchet hook 123b comes to be engaged with this indentation 131d and prevents any further rotary motion of the rotary member 130. The ratchet hooks 123b and 123c are individually so shaped that the former can but the latter cannot become engaged with the indentation 131d. By this means, the end position of the use of the ampoules 200 becomes clearly recognizable and the user can easily estimate how soon the rotary member 130 currently being used will have to be replaced by another holder loaded with a new set of unused ampoules 200.

[0065] Instead of the final position indicating indentation 131d as described above, or in addition thereto, the last of the holding members 134 to be used may be colored differently such that the user can even more easily estimate how soon the rotary member 130 will have to be replaced next.

[0066] The structure of the arm 150 is described next with reference to FIGS. 13 and 14 which are sectional views taken along line XIII—XIII of FIG. 2 at a time before injection and at the time of injection, respectively.

[0067] A tubular shaft holder 153 extending in the longitudinal direction is provided on the upper surface of the atomizer main frame 102. The front part of this shaft holder 153 contains therein a slidable shaft 152 so as to be both rotatable around its axis and slidable in the axial direction. A rotatable head 151 is provided on the front side of this shaft holder 153.

[0068] This slidable shaft 152 has an indented part 152a formed on its side surface near its back end for engaging and containing a sealing member 152b. An axially elongated hollow part 152c is formed at the back end part of the shaft 152, and a connecting hole 152d is formed for connecting the indented part 152a and the hollow part 152c. Under the condition shown in FIG. 13, this connecting hole 152d is closed by the sealing member 152b.

[0069] A piston 156 is disposed behind the shaft 152 inside the shaft holder 153. The piston 156 has a first cylindrical part 156a, a second cylindrical part 156b and a third cylindrical part 156c, the third cylindrical part 156c being between the first and second cylindrical parts 156a and 156b, as shown in FIGS. 13 and 14. A sealing member 158 is engaged on the outer peripheral surface of the third cylindrical part 156c. A coil spring (the first coil spring) 154 is inserted between the shaft 152 and the piston 156, and another coil spring (the second coil spring) 157 is disposed between the back part of the piston 156 and the back end of the shaft holder 153.

[0070] With the arm 150 thus structured, if its head 151 is pushed in, as indicated by arrow S1 shown in FIG. 14, the sealing member 152b moves towards the head 151 in the indented part 152a due to the friction with the inner wall of the shaft holder 153 and the connecting hole 152d comes to a position between the sealing members 152b and 158. Thus, the space containing the first coil spring 154 serves as an air damper, being sealed by means of the sealing members 152b and 158. Thus, the user will feel heavy as the head 151 is initially pushed in and will push it in steadily and slowly. As a result, the ampoule 200 will be made to approach the atomizing part 104 slowly. This is a favorable way of operation because if the medicament liquid is introduced to the atomizing part 104 energetically, it is likely to scatter around and the atomization of the specified quantity of the medicament liquid may not be achieved.

[0071] Thereafter, the shaft 152 switches on a limit switch 170 to have the control unit 160 activate the atomizing part 104 such that the medicament liquid will be instantaneously atomized.

[0072] As the compressive force on the head 151 is released, the biasing force of the first and second coil springs 154 and 157 causes the shaft 152 and the piston 156 to return to the positions shown in FIG. 13. At this moment, the sealing member 152b moves towards the back end side of indented part 152a by the friction with the inner wall surface of the shaft holder 153 and the connecting hole 152d connects the space containing the first coil spring 154 with the exterior space.

[0073] The structure of the head 151 and its positional relationship with the cover member 230 of the ampoules 200 are described next with reference to FIGS. 15-17.

[0074] As shown in FIG. 15, the head 151 is comprised of a vertical part 151a supporting the back part of the cover 230 for the ampoules 200 and a side part 151b positioned at a side of the upper part of the cover 230. A slit 151c is formed at a lower position of the side part 151b in a direction transverse to the axial direction of the shaft 152 so as to be able to accept the aforementioned second rib 232 on the cover 230.

[0075] As the rotary member 130 is rotated, the second rib 232 on the cover 230 of the incoming ampoule passes through the space formed by the slit 151c, as shown in FIGS. 16 and 17. Thus, the arm 150 does not interfere with the circular motion of the ampoules 200.

[0076] When the second rib 232 associated with one of the ampoules 200 is engaged with the slit 151c, as shown in FIG. 15, as the arm 150 is moved, the outlet 201h of the ampoule 200 can be moved between the advanced position towards the atomizing part 104 as shown in FIG. 14 and the retracted position as shown in FIG. 13 where the rotary member 130 can be rotated with respect to the atomizer main frame 102.

[0077] Since the head 151 will interfere with the rotary member 130 when the rotary member 130 loaded with ampoules 200 is mounted to or removed from the holder base 120, the head 151 should be rotated in the direction of arrow D shown in FIG. 15 so as to avoid the interference.

[0078] The operation of the medicament liquid atomizer 100 thus structured for injection of the medicament liquid is described next with reference to FIGS. 18-21. FIG. 18 is a sectional view taken along line XVIII—XVIII of FIG. 2 showing only relevant parts before injection. FIG. 19 is a corresponding sectional view at the time of injection. FIG. 20 shows a portion of FIG. 19 indicated by circle XX even more enlarged. FIG. 21 is another sectional view corresponding to FIGS. 18 and 19 after injection.

[0079] First, the rotary member 130 is rotated such that the outlet 201h of the ampoule 200 filled with a medicament liquid is at a position opposite the connector opening 110 near the atomizing part 104, as shown in FIG. 18. The user can easily ascertain through the window 142 in the cover 140 whether the ampoules 200 are properly mounted or whether they are properly filled with a medicament liquid.

[0080] Next, the arm 150 is pushed in the direction of arrow S1, as shown in FIG. 19. As a result, the cover member 230 moves in the direction of the first open part 201X and its pins 234 push the second piston 220 to cause needle-like sharp part 221 to penetrate the weakened part 211b of the first piston 210 such that the reservoir 201k and the passage 201j become connected and the medicament liquid 240 in the reservoir 201k is supplied to the atomizing part 104.

[0081] As shown more in detail in FIG. 20, the atomizing part 104 includes a horn vibrator 106 having on its upper surface a mesh 105 that extends sideways. Since the ampoule main body 201 has a forwardly protruding part with the guide groove 202, as explained above with reference to FIG. 7, the outlet 201h can be brought infinitely close to the horn vibrator 106 as the medicament liquid 240 is supplied to the atomizing part 104 and is instantaneously atomized.

[0082] The arm 150 is thereafter pulled back in the direction of arrow S2 in FIG. 21. As a result, the ampoule 200 is returned to the interior of the rotary member 130 and hence does not interfere with the rotary motion of the rotary member 130.

[0083] As explained above, since a plurality of ampoules 200 are carried in an annular formation, the space for storing them can be made compact. As a result, the ampoule holder 101 can be made compact and hence easily portable. The invention also makes it possible to set a plurality of ampoules 200 at once to the atomizer main frame 102 since the ampoules 200 may be preliminarily set in the rotary member 130. When the medicament liquid in all of the ampoules 200 has been used up, all of the used-up ampoules 200 can be removed at once with the rotary member 130 from the atomizer main frame 102 for replacement. In this manner, the used-up ampoules 200 can be neatly disposed of without getting scattered around.

[0084] Since the position of the ampoule 200 to be used first is uniquely determined with reference to the rotary member 130, its position when the last of the ampoules 200 has been used up is also uniquely determined. This makes it easy to estimate how soon the rotary member 130 must be replaced with a new one.

[0085] Since the outlet 201h of the ampoule 200 is at a retracted position away from the atomizing part 104 when the rotary member 130 rotates, there is no interference between the outlet 201h and the atomizing part 104. Thus, the atomizing part 104, which is a principal part of the atomizer main frame 102, need not be specially designed and the rotary member 130 can be made rotatable by a simple mechanism.

[0086] According to the present invention, furthermore, the medicament liquid 240 can be supplied into the tubular part 201Z without causing hardly any air to become mixed inside the reservoir 201k. Since the outlet 201h is integrally formed at one end of the tubular part 201Z, the distance of the flow route for the medicament liquid 240 is reduced and the amount of the liquid that may remain inside the tubular part 201Z can be reduced.

[0087] FIGS. 22 and 23 show another ampoule 200A according to another embodiment of the invention, FIG. 22 being its sectional view before injection and FIG. 23 being a corresponding sectional view after injection. This ampoule 200A is basically of the same structure as the ampoule 200 according to the first embodiment of the invention described above. The difference is in that the second piston 220 is not provided with any needle-like part (such as the part indicated by numeral 221) but that a sharpened part 254 is provided at the end of a guide tube 253 on the side of the second piston 220, having a tapered surface such that the its width increases from the side of the second piston 220 towards the outlet 201h.

[0088] If the amount of the medicament liquid to be stored inside the reservoir 201k is 20 microliters, the external dimensions of the ampoule 200A may be such that the total length L1 is 10.4 mm, the length of the cover member 230 is 8.6 mm and the outer diameter of the cover member 230 is about 6.3 mm.

[0089] If the cover member 230 of the ampoule 200A is moved in the direction of the first open part 201X, the first piston 210 moves such that the sharpened part 254 penetrates the weakened part 211b of the first piston 210. The reservoir 201k and the passage 201j thus become connected and the medicament liquid 240 can be discharged out of the reservoir 201k. The second embodiment of the invention described above enjoys the same advantages as the first embodiment of the invention when the medicament liquid is supplied into the ampoule main body 201A.

[0090] Although the invention has been described by way of only two embodiments, they are not intended to limit the scope of the invention. Many modifications and variations are possible within the scope of the invention. Although the invention was described above for an application wherein the ampoules are filled with a medicament liquid, the invention is applicable to all situations where a liquid is to be atomized. Although a main body structure adapted to be portable was illustrated, the invention is applicable equally well to non-portable devices. In summary, the description presented above is intended to be interpreted broadly.