Methods to identify modulators of the mevalonate pathway in sterol synthesis

Non-Patent Literature (60)

• Boguta et al. Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae. Gene 186:291-296, 1997.Applicant
• Arts, et al., “Identification of a nuclear export receptor for tRNA” Curr Biol 8:305-314, 1998.Applicant
• Bach, “Some new aspects of isoprenoid biosynthesis in plants—A review” Lipids 30:191-202, 1995.Applicant
• Bartz, et al., “N6-(Delta 2-isopentenyl)adenosine: Biosynthesis in vitro in transfer RNA by an enzyme purified from Escherichia coli” Biochem Biophys Res Commun 40:1481-1487, 1970.Applicant
• Benko, et al., “Competition between a sterol biosynthetic enzyme and the tRNA modification in addtion to changes in the protein synthesis machinery causes altered nonsense suppression” PNAS 97:61-66, 2000.Applicant
• Boguta, et al., “Subcellular locations of MOD5 proteins: mapping of sequences sufficient for targeting to mitochondria and demonstration that mitochondrial and nuclear isoforms commingle in the cytosol” Mol Cell Biol 14:2298-2306, 1994.Applicant
• Brown, et al., “Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B” B Engl J Med 323:1289-98, 1990.Applicant
• Brown and Goldsteins, “Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth” J Lipid Res. 21:505-517, 1980.Applicant
• Carlson and Botstein, et al., “Two differentially regulated mRNAs with different 5′ ends encode secreted with intracellular forms of yeast invertase”, Cell 28:145-154, 1982.Applicant
• Chen, et al., “PPQ, a novel protein phosphatase containing a Ser+Asn-rich amino-terminal domain, is invovled in the regulation of protein synthesis” Eur. J. Biochem 218:689-699, 1993.Applicant
• Chijiwa and Linscheer's (Chijiwa and Linscheer, “Effect of intraluminal pH on cholesterol and oleic acid absorption from micellar solutions in rat” Am J. Physiol 246:G492-G499, 1984.Applicant
• Dihanich, et al., “Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and Mittochondrial tRNAs of Saccharomyces cerevisiae” Mol Cell Biol 7:177-184, 1987.Applicant
• Donald, et al., “Effects of overproduction of the catalytic domian of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae” Appl Environ Microbiol 63:3341-3344, 1997.Applicant
• Endo, et al., “Beneficial effects of dietary intervention on serum lipid and apolipoprotein levels in obese children” Am J Dis Child 146:303-305, 1992.Applicant
• Endo, et al., “Oxygenated cholesterols as ligands for cytosolic-nuclear tumor promoter binding protein: yakkasteroids” Biochem Biophys Res Commun 194:1529-35, 1993.Applicant
• Endo, “The discovery and development of HMG-CoA reductase inhibitors” J Lipid Res 33:1569-1582, 1992.Applicant
• Endres et al., “Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion” Neurosci Lett. 248:41-41, 1998.Applicant
• Frantz and Gilbert, “A novel yeast gene product, G4p1, with a specific affinity for quadruplex nucleic acids” J. Biol Chem 270:20692-20697, 1995.Applicant
• Gibbs and Oliff, “The potential of farnesyltransferase inhibitors as cancer chemotherapeutics” Annu Rev Pharmacol Toxicol. 37:143-66, 1997.Applicant
• Gietz, et al., “Improved method for high efficiency transformation of intact yeast cells” Nucleic Acids Res 20:1425, 1992.Applicant
• Gillman, et al., “MODS translaion initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA” Mol Cell Biol 11:2382-2390, 1991.Applicant
• Goldstein and Brown, “Regulation of the mevalonte pathway” Nature 343:425-430, 1990.Applicant
• Hinnebusch and Liebman, in The molecular and cellular biology of the yeast Saccharmyces: Genomic dynamics, protein synthesis and energetics eds. Broach, et al. “Protein Synthesis and Translational Control in Saccharomyces cerevisiae” [Cold Spring Harbor Lab Press, Plainview, NY] vol. 1, pp. 627-735, 1991.Applicant
• Hopper, et al., “Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs” Cell 19:741-751, 1980.Applicant
• Janssen and Möller, “Elongation factor 1 β γ from Artemia. Purification and properties of its subunits” Eur J Biochem 171:119-129, 1988.Applicant
• Kinzy, et al., “Multiple genes encode the translation elongation factor EF-1γ in Saccharomyces cerevisiae” Nucleic Acids Res 22:2703-2707, 1994.Applicant
• Kline, et al., “N6-(Δ2-Isopentenyl) adenosine. Biosynthesis in transfer ribonucleic acid in vitro” Biochemistry 8:4361-4371, 1969.Applicant
• Laten, et al., “Isopentenyladenosine deficient tRNA from an antisuppressor mutant of Saccharomyces cerevisiae” Nucleic Acids Res 5:4329-4342, 1978.Applicant
• Laufs et al., “Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors” Circulation 97:1129-35, 1998.Applicant
• Liu, et al., “Construction of a GALI-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast” Genetics 132:665-673, 1992.Applicant
• Lund and Dahlberg, “Proofreading and aminoacylation of tRNAs before export from the nucleus” Science 282:2082-2085, 1998..Applicant
• Martin and Hopper, “Isopentenuylation of both cytoplasmic and mitochondrial tRNA is affected by a single nuclear mutation” J Biol Chem 257:10562-10565, 1982.Applicant
• McCloskey and Nishimuta, “Modified Nucleosides in Transfer RNA” Acc. Chem. Res. 10:403-410, 1977.Applicant
• McKnight et al., “Selection of Functional cDNAs by complementation in yeast,” PNAS 80:4412-4416, 1983.Applicant
• Najarian et al., “DNA Sequence and Transcript Mapping of MOD5: Features of the s′ Region which Suggest Two Translational Starts,” Mol. Cell. Biol. 7:185-191, 1987.Applicant
• Nash, “Meeting National Cholesterol Education Goals in Clinical Practice-A Comparison of Lovastatin and Fluvastatin in Primary Prevention,” Am. J. Cardiol. 78(SuppL. 6A):26:31, 1996.Applicant
• Nasmyth and Tatchell, “The structure of transposable yeast mating type loci” Cell 19:753-764, 1980.Applicant
• Ono et al., “Nonsense Mutations in the canl Locus of Saccharomyces cerevisiae,” J. Bacteriology 154:1476-1479, 1983.Applicant
• Rasmussen and Culbertson, “Analysis of yeast trimethylguanosine-capped RNAs by Midwestern blotting” Gene 182:89-96, 1996.Applicant
• Rasse-Messenguy and Fink, “Temperature-sensitive nonsense suppressors in yeast” Genetics 75:459-464, 1973.Applicant
• Rine, “Gene overexpression in studies of Saccharomyces cerevisiae” Method Enzymol 194:239-251, 1991.Applicant
• Rosenbaum and Gefter, “Δ2-Isopentenylpyrophosphate: Transfer Ribonucleic Acid Δ2-Isopentenyltransferase from Escherichia coli. Purification and properties of the enzyme” J. Biol Chem 247:5675-5680, 1972.Applicant
• Rothstein, “Targeting, Disruption, replacement, and allele rescue: integrative DNA transformation in yeast” Methods Enzymol 194:281-301, 1991.Applicant
• Sanger, et al., “DNA sequencing with chain-terminating inhibitors” Proc. Natl Acad Sci USA 74:5463-5467, 1977.Applicant
• Sarkar, et al., “Nuclear tRNA aminocylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae” PNAS 96:14366-14371, 1999.Applicant
• Sarkar and Hopper, “tRNA nuclear export in Saccharomyces cerevisiae: in situ hybridization anlaysis” Mol Biol Chell 9:3041-3055, 1998.Applicant
• Senapathy and Jacob, “Identification and purification of tRNAs containing N6-(delta 2-isopentenyl) adenosine using antibodies specific for N6-(delta-isopentenyl) adenosine” J Biol Chem 256:11580-11584, 1981.Applicant
• Simos, et al., “The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl-and glutamyl-tRNA synthetases” EMBO J 15:5437-5448, 1996.Applicant
• Sinensky, et al., “Differential inhibitory effects of lovostatin on protein isoprenylation and sterol synthesis” J Biol Chem 265:19937-19941, 1990.Applicant
• Sinha et al., “Polymer support oligonucleotide synthesis XVIII1.2: use of β-cyanoethyl-N, N-dialkylamino-/N-morppholono phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product,” Nucleic Acids Res. 12:4539-4557, 1984.Applicant
• Song, et al., “Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae” Mol Cell Biol 9:4571-4575, 1989.Applicant
• Stansfield, et al., “The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae”EMBO J 14:4365-4373, 1995.Applicant
• Stansfield and Tuite, “Polypeptide chain termination in Saccharomyces cerevisiae” Curr Genet 25:385-395, 1994.Applicant
• Tanimoto et al., “Inhibitory activity to protein prenylation and antifungal activity of zaragozic acid D3, a potent inhibitor of squalene synthase produced by the fungus, Mollisia sp SANK 10294” J. Antibiot (Tokyo) 51:428-431, 1998.Applicant
• Vincent, et al.,“the yeast translational allosuppressor, SAL6: a new memeber of the PP1-like phosphatase family with a long serine-rich N-terminal extension” Genetics 138:597-608, 1994.Applicant
• Voet and Voet, in Biochemistry “Lipid Metabolism,” John Wiley & Sons, Inc. Chapter 23 pp. 645-657, 1990.Applicant
• Ward, “Single-step purification of shuttle vectors from yeast for high frequency back-transformaation into E.coli” Nucleic Acids Res 18:5319, 1990.Applicant
• Whelan et al., “The CANI locus of Saccharomyces cerevisiae: fine-structure analysis and forward mutation rates” Genetics 91:35-51, 1979.Applicant
• Woolford and Warner, in The molecular and cellular biology of the yeast Saccharomyces: Genomic dynamics, protein synthesis and energetics eds., Broach, et al. “The Ribosome and Its Synthesis” [Cold Spring Harbor Lab Press, Plainview, NY] vol. 1, pp. 587-626, 1991.Applicant
• Zoladek et al., “Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3'ends and/or protein synthesis in mitochondrial delivery” Mol Cell Biol. 15:6884-6894, 1995.Applicant