Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody

Patent Citations (12)

Non-Patent Literature (29)

• Ngo et al, 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.Applicant
• Kuby et al, 1994, Immunology, Second edition, pp. 86-96.Applicant
• Colman et al, 1994, A structural view of immune recognition by antibodies, pp. 33-36.Applicant
• Ruf et al, “Purification, sequence and crystallization of an anti-tissue factor Fab and its use for the Crystallization of tissue factor”, J. of Crystal Growth 122 (1992), pp. 253-264, Elsevier Science, Pub. B.V.Applicant
• Maeda et al, “Construction of reshaped human antibodies with HIV-neutralizing activity”, Hum, Antibod. Hydridomas, vol. 2 (1991), pp. 124-134, Butterworth-Heinemann.Applicant
• Hougs et al, “Rapid analysis of rearranged Kappa light chain genes of circulating polysaccharide-specific B Lymphocytes by means of immunomagnetic beads and the polymerase chain reaction”, Exp. Clin. Immunogenet, 10 (1993), pp. 141-151, S. Karger AG, Basel.Applicant
• Epp et al, “The molecular structure of a dimer composed of the variable portions of the Bence-Jones Protein REI refined at 2.0-Å Resolution”, Biochemistry, vol. 14, No. 22, (1975), pp. 4943-4952, Max-Planck Institut.Applicant
• Bejcek et al, “Development and characterization of three recombinant single chain antibody fragments (scFvs) Directed against the CD19 antigen1” Cancer Research 55, (1995), pp. 2346-2351.Applicant
• Sato et al, “Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth1” Cancer Research 53, (1993), pp. 851-856.Applicant
• Welschof et al, “Amino acid sequence based PCR primers for amplification of rearranged human heavy and light chain immunoglobulin variable region genes”, J. of Immunological Methods 179, (1995) pp. 203-214 Elsevier Science B.V.Applicant
• Tempest et al, “Reshaping a human monoclonal antibody to inhibit human respiratory syncytial virus infection in vivo”, Bio/Technology vol. 9, (1991) pp. 266-271, Scotgen Limited.Applicant
• Kettleborough et al, “Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of Framework residues on loop conformation”, Protein Engineering vol. 4, No. 7 (1991) pp. 773-783 Oxford University Press.Applicant
• Cunningham et al, “The covalent structure of a human γG-Immunoglobulin. VII. Amino Acid Sequence of Heavy-Chain Cyanogen Bromide Fragments H1-H4*”, Biochemistry, vol. 9, No. 16. (1970), Rockerfeller Univ.Applicant
• Poljak et al, Amino Acid sequence of the VH Region of a human myeloma immunoglobulin (IgG New) BioChemistry vol. 16, No. 15, (1977) pp. 3412-3420.Applicant
• Tonge et al, “Cloning and characterization of 1116NS19.9 heavy and light chain cDNAs and expression of Antibody fragments in Escherichia coli”, Terhorst C, Malavasi F. Albertini A (eds): Generation of Antibodies by Cell and Gene Immortalization, Year Immunol. Basel, Karger, vol. 7, pp. 56-62 (1993).Applicant
• Man Sung Co et al, “Humanized antibodies for antiviral therapy”, Proc. Natl. Acad. Sci., vol. 88, pp. 2869-2873 (1991), Protein Design Labs, Inc.Applicant
• Gorman et al, “Reshaping a therapeutic CD4 antibody”, Proc. Natl. Acad. Sci. vol. 88, pp. 4181-4185 (1991) Dept of Pathology, Univ of Cambridge.Applicant
• Collet et al, “A binary plasmid system for shuffling combinatorial antibody libraries”, Proc. Natl. Acad. Sci. vol. 89, pp. 10026-10030 (1992), Dept. of Chemistry & Molecular Biology.Applicant
• Borretzen et al, “Control of autoantibody affinity by selection against amino acid replacements in the Complementarity-determining regions”, Proc. Natl. Acad. Sci., vol. 91, pp. 12917-12921 (1994).Applicant
• Verhoeyen et al, “Reshaping human antibodies: grafting an antilysozyme activity”, Science vol. 239 (1988) Medical research council lab. Of molecular biology.Applicant
• Ito et al, “Characterization of functionally important regions of tissue factor by using monoclonal antibodies”, J. Biochem. vol. 114, No. 5, pp. 691-696, (1993), Dept. of Molecular Biology.Applicant
• Pascual et al., “The complete nucleotide sequences of the heavy chain variable regions of six monospecific Rheumatoid factors derived from epstein-barr virus-transformed B cells isolated from the synovial tissue Of patients with rheumatoid arthritis”, J. Clin. Invest. (1990), vol. 86, pp. 1320-1328, Amer.Soc. of Clin. Invt.Applicant
• N. van der Stoep et al, “Molecular evolution of the human immunoglobulin E response: high incidence of Shared mutations and clonal relatedness among ε VH5 transscripts from three unrelated patients with atopic Dermatitis”, J. Exp. Med., vol. 177, (1993) pp. 99-107, The Rockerfeller University Press.Applicant
• Hillson et al, “The structural basis of germline-encoded VH3 Immunoglobulin binding to staphylococcal Protein A”, J. Exp. Med., vol. 178, (1993) pp. 331-336, The Rockerfeller University Press.Applicant
• Man Sung CO et al, “Chimeric and humanized antibodies with specificity for the CD33 antigen”, J. of Immun. vol. 148, No. 4, pp. 1149-1154, (1992), Amer. Assoc. of Immunologists.Applicant
• Riechmann et al, “Reshaping human antibodies for therapy”, Nature, vol. 332, pp. 323-327 (1988) Dept. of Molecular Biology, The research institute of Scripps Clinic.Applicant
• Cox et al, “A directory of human germ-line Vx segments reveals a strong bias in their usage”, Eur. J. Immunol. 24:827-823, (1994), VCH Verlagsgesellschaft mbH.Applicant
• Carter et al, “Humanization of an anti-p185HER2 antibody for human cancer therapy”, Proc. Natl. Acad. Sci. vol. 89, pp. 4285-4289, (1992).Applicant
• Hiroshi Noguchi “Theory and Clinical Application of Chimera Antibody and Humanized Antibody,” Journal of Clinical and Experimental Medicine,k 167:457-462 (1963).Applicant