Method of administering a therapeutically active substance

Patent Citations (32)

Non-Patent Literature (64)

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• Kong et al., “Intralesionally Implanted Cisplatin Plus Systemic Carmustine for the Treatment of Brain Tumor in Rats,” Journal of Surgical Oncology, 69: 76, 1998.Applicant
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• Conforti et al., “Anti-inflammatory Activity of Polyphosphazene-based Naproxen Slow-release Systems,” J. Pharm. Pharmacol, 48: 468, 1996.Applicant
• Straw et al., “Effects of Cis-Diammindeichloroplatinum II Released from D,L-Polylactic Acid Implanted Adjacent to Cortical Allografts in Dogs,” Journal of Orthopaedic Research, 12: 871, 1994.Applicant
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• Grossman et al., “The Intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers,” J. Nuerosurg, 76: 640, 1992.Applicant
• Chattaraj et al., “Biodegradable microparticles of influenza viral vaccine: comparison of the effects of routes of administration on the in vivo immune response in mice,” Journal of Controlled Release, 58: 223, 1999.Applicant
• Yoshida et al., “In vivo release of cisplatin from a needle-type copolymer formulation implanted in rat kidney,” Biomaterials, 10:, 17, 1989.Applicant
• Cardinale et al., “Effect of Interstitial and/or Systemic Delivery of Tirapazamine on the Radiosensitivity of Human Glioblastoma Multiforme in Nude Mice,” Radiation Oncology Investigations, 6: 63, 1998.Applicant
• Valtonen et al., “Interstitial Chemotherpy with Carmustine-loaded Polymers for High-grade Gliomas: A Randomized Double-blind Study,” Neurosurgery, 41: 44, 1997.Applicant
• Yuan et al., “Implantable Polymers for Tirapazamine Treatments of Experimental Intracranial Malignant Glioma,” Radiation Oncology Investigation, 7: 218, 1999.Applicant
• Ewend et al., “Local Delivery of Chemotherapy and Concurrent External Beam Radiotherapy Prolongs Survival in Metastatic Brain Tumor Models1,” Research, 56: 5217, 1996.Applicant
• Yapp et al., “Tumor Treatment by Sustained Intratumoral Release of Cisplatin: Effects of Drug Alone and Combined with Radiationl” 39:497, 1997.Applicant
• Yapp et al., “The Potentiation of the Effect of Radiation Treatment by Intratumoral Delivery of Cisplatin,” Int. J. Radiation Oncology Biol. Phys., 42: 413, 1998.Applicant
• Yapp et al., “Radiosensitization of a mouse tumor model by sustained intra-tumoral release of Etanidazole and Tirapazamine using a biodegradable polymer implant device,” Radiotherapy and Oncology, 53: 77, 1999.Applicant
• Brem et al., “Placebo-controlled trail of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas,” Lancet, 345: 1008, 1995.Applicant
• Brem et al., “Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the moneky brain,” J. Neurosurg., 80: 283, 1994.Applicant
• Dash, A. and G. Cudworth II, “Therapeutic Applications of Implantable Drug Delivery Systems,” JPM, 40: 1, 1998.Applicant
• Harper et al., “Enhanced Efficacy of a Novel Controlled Release Paclitaxel Formulation (PACLIMER Delivery System) for Local-Regional Therapy of Lung Cancer Tumor Nodules in Mice1,” Clinical Cancer Research, 5: 4242, 1999.Applicant
• Yapp et al., “Cisplatin delivery by biodegradable polymer implant is superior to systemic delivery by osmotic pump or i.p. injection in tumor-bearing mice,” Anti-Cancer Drugs, 9: 791, 1998.Applicant
• Fowler et al., “Evaluation of an Implant that Delivers Leuprolide for 1 Year for the Palliative Treatment of Prostate Cancer,” Urology, 55: 639, 2000.Applicant
• Camarata et al., “Sustained release of nerve growth factor from biodegradable polymer microspheres,” Neurosurgery, 30: 313, 1992.Applicant
• Chen et al., “Carboplatin-loaded PLGA microspheres for intracerebral implantation: in vivo characterization,” Drug Delivery, 4: 301, 1997.Applicant
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• During et al., “Controlled release of dopamine from a polymeric brain implant: in vivo characterization,” Ann. Neurology, 25: 351, 1989.Applicant
• Menei et al., “Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma,” Cancer, 86: 325, 1999.Applicant
• Moritera et al., “Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy,” Invest Ophthalmol Vis Sci, 33: 3125, 1992.Applicant
• Tamargo et al., “Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate,” J Neurooncol, 9: 131, 1990.Applicant
• Tamargo et al., “Interstitial delivery of dexamethasone in the brain for the reduction of peritumoral edema,” J Neurosurg, 74: 956, 1991.Applicant
• Weingart et al., “Local delivery of the topoisomerase I inhibitor camptothecin prolongs survival in the rat intracranial 9L gliosarcoma model,” Int J Cancer, 62: 1, 1995.Applicant
• Williams et al., “Synthetic, implantable polymers for local delivery of IUDR to experimental human malignant glioma,” IJROBP, 42: 631, 1998.Applicant
• Qian et al., “Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods,” J. Biomed Mater Res., 55: 512, 2001.Applicant
• Beer et al., “Extended release if adenovirus from polymer microspheres: potential use in gene therapy for brain tumors,” Advanced Drug Delivery Reviews, 27: 59, 1997.Applicant
• Kunou et al., “Controlled intraocular delivery of ganciclovir with use of biodegradable scleral implant in rabbits,” Journal of Controlled Release, 37: 143, 1995.Applicant
• Reinhard et al., “Polymeric controlled release of dexamethasone in normal rat brain,” Journal of Controlled Release, 16: 331, 1991.Applicant
• Sanchez et al., “In Vivo Study of the Tissue Distribution and Immunosuppressive Response of Cyclosporin A-Loaded Polyester Micro-and Nanospheres,” Drug Delivery, 2: 21, 1995.Applicant
• Alonso et al., “Biodegradable microspheres as controlled-release tetanus toxoid delivery systems,” Vaccine, 12: 299, 1994.Applicant