Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd534 as a target

Patent Citations (11)

Non-Patent Literature (92)

• Papadaki et al. (Biotechnol. Prog., 13:209-221, 1997).Applicant
• Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al., (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.Applicant
• Gene bank, AC: AA350793, Adams et al. (Nature Genet. 4:256-267, 1993).Applicant
• Hakes et al. (P.N.A.S., vol. 88, pp. 6186-6109, 1991).Applicant
• Kanai et al. (Science, vol. 268, May 12, 1995).Applicant
• Harrison et al. (FEBS Lett. 318, 1:17-22, 1993).Applicant
• The WashU-Merck EST Project (published Jun. 27, 1995, AN: H12679, Gene Bank).Applicant
• Wallace et al. (Methods in Enzymology (1987), 152:432).Applicant
• Sambrook et al. (Molecular Cloning (1989), CSH:11.47).Applicant
• Leiw et al., PNAS, vol. 91, pp. 10645-10649, 1994.Applicant
• Gene Bank (AN: T20268, D345F Homo sapiens cDNA clone D345, Nov. 28, 1994).Applicant
• W.M. Barnes, 1994, “PCR amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates”, Proc. Natl. Acad. Sci. USA 91:2216-2220.Applicant
• Bevilacqua et al., 1989, “Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins”, Science 243:1160-1165.Applicant
• Bevilacqua et al., 1991, “Selectins: A family of adhesion receptors”, Cell 67:233.Applicant
• Black et al., 1994, “Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy on ovariectomized rats”, J. Clin .Invest. 93:63-69.Applicant
• Boise et al., 1993, “bcl-x, a bcl-2-Related gene that functions as a dominant regulator of apoptotic cell death”, Cell 74:597-608.Applicant
• Cercek et al., 1990, “Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation”, Circulation Res. 66:1755-1760.Applicant
• Cheng et al., 1994, “Effective amplification of long targets form cloned inserts and human genomic DNA”, Proc. Natl. Acad. Sci. USA 91:5695-5699.Applicant
• Cleary et al., 1986, “Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/Immunoglobulin transcript resulting from the t(14;18) translocation”, Cell 47:19-28.Applicant
• Coffman et al., 1990, “Xotch, the Xenopus homolog of Drosophila Notch”, Science 249:1438-1441.Applicant
• Cybulsky & Gimbrone, 1991, “Endothelial expression of a mononulcear leukocyte adhesion molecule during atherogenesis”, Science 251:788-791.Applicant
• Davies et al., 1986, “Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro”, Proc. Natl. Acad. Sci. USA 83:2114-2117.Applicant
• M.A. Gimbrone, 1976, “Culture of vascular endothelium” Progress in Hemostasis and Thrombosis Grune & Stratton Inc., NY, 3:1-28.Applicant
• Gromadzinska & Sklodowska, 1990, “Erythrocyte glutathione peroxidase and myocardial infarction”, JAMA 263:949-950.Applicant
• Guidi et al., 1986, “Platelet glutathione peroxidase activity is impaired in patients with coronary heart disease”, J. Clin. Lab Invest. 46:549-551.Applicant
• Hakes & Berezney, 1991, “Molecular cloning of matrix F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs”, Proc. Natl. Acad. Sci. USA 88:6186-6190.Applicant
• K. Heckl, 1988, “Isolation of cNDAs encoding human manganese superoxide dismutase”, Nucl. Acids Res. 16:6224.Applicant
• Hockenbery et al., 1993, “Bcl-2 functions in an antioxidant pathway to prevent apoptosis”, Cell 75:241-251.Applicant
• Jones et al., 1993, “Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines”, J. Biol. Chem. 268:9049-9054.Applicant
• Kita et al., 1987, “Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia”, Proc. Natl. Acad. Sci. USA 84:5928-5931.Applicant
• Kok et al., 1989, “Decreased selenium levels in acute myocardial infarction”, JAMA 261:1161-1164.Applicant
• Kumar & Chambon, 1988, “The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer”, Cell 55:145-156.Applicant
• Kume et al., 1992, “Lysophosphatidylcholine, a component of atherogenic lipoprotein, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells”, J. Clin. Invest. 90:11138-1144.Applicant
• Majesky et al., 1990, “PDGF ligand and receptor gene expression during repair of arterial injury”, J. Cell Biol. 111:2149-2158.Applicant
• Malden et al., 1991, “The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages”, J. Biol. Chem. 266:13901-13907.Applicant
• Nagel et al., 1994, “Shear stress selectively upregualtes intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells”, J. Clin. Invest. 94:885-891.Applicant
• Navab et al., 1988, “Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells”, J. Clin. Invest. 82:1853-1863.Applicant
• Ohno et al., 1994, “Gene therapy for vascular smooth muscle cell proliferation after arterial injury”, Science 265:781-784.Applicant
• Oltvai et al., 1993, “Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death”, Cell 74:609-619.Applicant
• Osborn et al., 1989, “Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lympocytes”, Cell 59:1203-1211.Applicant
• Plump et al., 1992, “Severe hypercholesterolemia and atherosclerosis in apolipoprotein e-deficient mice created by homologous recombination in ES cells”, Cell 71:343-353.Applicant
• Porter et al., 1992, “Plasma, platelet and erythrocyte glutathione peroxidase as risk factors in ischaemic heart disease in man”, Clinical Science 83:343-345.Applicant
• Poston et al., 1992, “Expression of intercellular adhesion molecule-1 in atherosclerotic plaques”, Am. J. Pathol. 140:665-673.Applicant
• Rapacz et al., 1986, “Lipoprotein mutations in pigs are associated with elevated plasma cholesterol and atherosclerosis”, Science 234:1573-1577.Applicant
• Resnick et al., 1993, “Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element”, Proc. Natl. Acad. Sci. USA 90:4591-4595.Applicant
• R. Ross, 1993, “The pathogenesis of atherosclerosis: Perspective for the 1990s”, Nature 362:801-809.Applicant
• Simmons et al., 1988, “ICAM, an adhesion ligand of LFA-1, is homologous to neural cell adhesion molecule NCAM”, Nature 331:624-627.Applicant
• Speir et al., 1994, “Potential role of human cytomegalovirus and p53 interaction in coronary restenosis”, Science 265:391-394.Applicant
• Shreeniwas et al., 1991, “Reoxygenation stimulates IL-1α production, increasing leukocyte adherence to endothelium via expression of ICAM-1 and ELAM-1”, Arterioscler. Council Abstracts 11:1397a.Applicant
• Takahashi et al., 1990, “Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences”, J. Biochem. 108:145-148.Applicant
• Takayama et al., 1995, “Cloning and functional analysis of BAG-1: A novel Bcl-2-Binding protein with anti-cell death activity”, Cell 80:279-284.Applicant
• Tanaka et al., 1993, “Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury”, Circulation 88:1788-1803.Applicant
• Tsujmoto et al., 1984, “Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation”, Science 226:1097-1099.Applicant
• Wang et al., 1981, “Selenium and myocardial infarction: Glutathione peroxidase in platelets”, Klin. Wochenschr. 59:817-818.Applicant
• Wilson et al., 1994, “2.2 Mb of contiguous nucleotide ssequence from chromosome III of C. elegans”, Nature 368:32-38.Applicant
• Xu et al., 1994, “Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter”, Proc. Natl. Acad. Sci. USA 91:2201-2205.Applicant
• Yoshimura et al., 1994, “The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32”, Gene 145:293-297.Applicant
• Grainger et al., 1993, “Proliferation of human smooth muscle cells promoted by lipoprotein(a)”, Science 260:1655-1658.Applicant
• Puolakkainen et al., 1993, “Serological response to Chlamydia pneumoniae in adults with coronary arterial fatty streaks and fibrolipid plaques”, J. of Clinical Microbiol. 31:2212-2214.Applicant
• Farrow et al., 1995, “Cloning of bcl-2 homologue by interaction with adenovirus E1B 19K”, Nature 374:731-733.Applicant
• Kanai et al., 1995, “Identification and characterization of a prostaglandin transporter”, Science 268:866-869.Applicant
• Luscinskas et al., 1989, “Endothelial-Leukocyte adhesion molecule 1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium”, J. Immunol. 142:2257-2263.Applicant
• Sekelsky et al., 1995, “Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster”, Genetics 139:1347-1358.Applicant
• Bartel et al., 1993, “Using the two-hybrid system to detect protein-protein interactions”, Cellular Interactions in Dev. Chap. 7, pp. 153-159.Applicant
• Bird et al., 1988, “Single-chain antigen-binding proteins”, Science 242:423-426.Applicant
• Blachly-Dyson et al., 1993, “Cloning and functional expression in ueast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel”, J. Biol. Chem. 268:1835-1841.Applicant
• Border & Noble, 1995, “Targeting TGF-β for treatment of disease”, Nature Med. 1:1000-1001.Applicant
• Charles et al., 1993, “Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein”, Oncogene 8:797-801.Applicant
• Chen et al., 1996, “A transcriptional partner for MAD proteins in TGF-β signaling”, Nature 383:691-696.Applicant
• A. Coghlan, 1995, “Gene dream fades away”, New Scientist :14-15.Applicant
• Diamond et al., 1993, “Novel delayed-early and highly insulin-induced growth response genes”, J. Biol. Chem. 268:15185-15192.Applicant
• Eppert et al., 1996, “MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma”, Cell 86:543-552.Applicant
• Grainger et al., 1995, “Tamoxifen elevates transforming growth factor-β and suppresses diet-induced formation of lipid lesions in mouse aorta”, Nature Med. 1:1067-1073.Applicant
• T. Gura et al., 1995, “Estrogen: Key player in heart disease among women”, Science 269:771-773.Applicant
• Hochman et al., 1995, “Dissociation of synchronization and excitability in furosemide blockage of epileptiform activity”, Science 270:99-102.Applicant
• Hoodless et al., 1996, “MADR1, a MAD-related protein that functions in BMP2 signaling pathways”, Cell 85:489-500.Applicant
• Kojima et al., 1991, “Lipoprotein (a) inhibits the generation of transforming growth factor β: An endogenous inhibitor of smooth muscle cell migration”, J. Cell Biol. 113:1439-1445.Applicant
• F. Ledley, 1995, “Nonviral gene therapy: The promise of genes as pharmaceutical products”, Human Gene Therapy 6:1129-1144.Applicant
• Li et al., 1991, “Early induction of an atherosclerosis-associated endothelial-leukocyte adhesion molecule (athero-ELAM) by an atherogenic diet in rabbits”, Arterioscler. Thromb. 11:1397a.Applicant
• E. Marshall, 1995, “Less hype, more biology needed for gene therapy”.Applicant
• E. Marshall, 1995, “Gene therapy's growing pains”, Science 269:1050-1055.Applicant
• Nikol et al., 1992, “Expression of transforming growth factor-β1 is increased in human vascular restenosis lesions”, J. Clin. Invest. 90:1582-1592.Applicant
• Orkin & Motulsky, 1995, “Report and recommendations of the panel to assess the NIH investment in research on gene therapy”, NIH Report.Applicant
• Raftery et al., 1988, “Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila”, Genetics 139:241-254.Applicant
• Sambrook et al.(eds), 1989, “Estimating the Effects of Mismatches”, Molecular Cloning—A Laboratory Manual 2nd Edition, p. 11.47.Applicant
• Serra & Moses, 1996, “Tumor suppressor genes in the TGF-β signaling pathway?”, Nature Med. 2:390-391.Applicant
• Wallace & Miyada, 1987, “Oligonucleotide probes for the screening of recombinant DNA libraries”, Methods in Enzymology 152:432-443.Applicant
• Wieser et al., 1995, “GS domain mutation that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex”, EMBO J. 14:2199-2208.Applicant
• Wrana et al., 1994, “Mechanism of activation of the TGF-β receptor”, Nature 370:341-347.Applicant
• Patrick Jr., et al., 1995, “Shear stress and cyclic strain moduclation of gene expression in vascular endothelial cells”, Blood Purification 13:112-124.Applicant
• Shyy et al., 1995, “Multiple cis-elements mediate shear stress-induced gene expression”, J. Biomechanics 28:1451-1457.Applicant
• Weatherall, D.J., 1995, “Scope and limitations of gene therapy”, British Medic.Applicant