Diagnosis and treatment of AUR-1 and/or AUR-2 related disorders

Patent Citations (23)

Non-Patent Literature (152)

• Abe et al., “Molecular Characterization of a Novel Metabotropic Glutamate Receptor mGluR5 Coupled to Insitol Pohosphate/Ca2+ Signal,” J. Biol. Chem. 267(19):13361-13368 (1992).Applicant
• Alberts, B. et al., Molecular Biology of the Cell, Second Edition, published 1989, by Garland Publishing (New York) pp. 265-266. (Table of Contents Only).Applicant
• Allen et al., “Modulation of CD4 by suramin,” Clin. Exp. Immunol. 91:141-146 (1991).Applicant
• Altschul et al., “Basic Local Alignment Search Tool,” J. Mol. Biol. 215:403-410 (1990).Applicant
• Anafi et al., “Tyrphostin-Induced Inhibition of p210bcr-abl Tyrosine Kinase Activity Induces K562 to Differentiate,” Blood 82:3524-3529 (1993).Applicant
• Baker et al., “Induction of acetylcholine receptor clustering by native polystyrene beads,” Journal of Cell Science 102:543-555 (1992).Applicant
• Barker et al., “In vitro activity of non-glutamate containing quinazoline-based thymidylate synthase inhibitors,” Proceedings of the American Association for Cancer Research 32:327 at abstract No. 1939 (1991).Applicant
• Bayer et al., “The Avidin-Biotin Complex in Affinity Cytochemistry,” Methods in Enzymology 62:308-319 (1979).Applicant
• Benoist and Chambon, “In vivo sequence requirements of the SV40 early promoter region,” Nature 290:304-310 (1981).Applicant
• Bertino, “Toward Improved Selectivity in Cancer Chemotherapy: The Richard and Hinda Rosenthal Foundation Award Lecture,” Cancer Research 39:293-304 (1979).Applicant
• Bigner et al., “Structural Chromosomal Abnormalities in Human Medulloblastoma,” Cancer Genet Cytogenet 30:91-101 (1988).Applicant
• Bilder et al., “Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells,” Am. J. Physiol. 260(Cell Physiol.29):C721-C730 (1991).Applicant
• Bockmuhl et al, Laryngorhinootologie 75:408-414 (1996).Applicant
• Bollon and Stauver, “DNA Transformation Efficiency of Various Bacterial and Yeast Host-Vector Systems,” Journal of Clinical Hematology and Oncology 10(2&3):39-48 (1980).Applicant
• Botstein et al., “Making Mutations in vitro and Putting Them Back into Yeast,” Miami Winter Symposia—From Gene to Protein: Translation into Biotechnology, edited by Ahmad et al., Academic Press, 19:265-274 (1982).Applicant
• Brinster et al., “Factors Affecting the Efficiency of Introducing Foreign DNA into Mice by Microinjecting Eggs,” Proc. Natl. Acad. Sci. USA 82:4438-4442 (1985).Applicant
• Broach, “The Yeast Plasmid 2μ Circle,” Cell 28:203-204 (1982).Applicant
• Broach, In: The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY p. 445-470 (1981).Applicant
• Bryckaert et al., Experimental Cell Research 199:255-261 (1992).Applicant
• Bullock et al., “Techniques in Immunocytochemistry,” Academic Press, Orlando, FL: vol. 1 (1982), vol. 2 (1983), vol. 3 (1985) (Table of Contents Only).Applicant
• Burke et al., “Arylamides of Hydroxylated Isoquinolines as Protein-Tyrosine Kinase Inhibitors,” Bioorganic & Medical Chemistry Letters 2(12):1771-1774 (1992).Applicant
• Burke et al., “Bicyclic Compounds as Ring-Constrained Inhibitors of Proein-Tyrosine Kinase p56lck 1,” Journal of Medicinal Chemistry 36(4):425-432 (1993).Applicant
• Capecchi, “High Efficiency Transformation by Direct Microinjection of DNA into Cultured Mammalian Cells,” Cell 22:479-488 (1980).Applicant
• Capecchi, “Altering the Genome by Homologous Recombination,” Science 244:1288-1292 (1989).Applicant
• Chan and Botstein, “Isolation and Characterization of Chromosome-Gain and Increase-in-Ploidy Mutants in Yeast,” Genetics 135:677-691 (1993).Applicant
• Chard, “An Introduction to Radioimmunoassay and Related Techniques,” Elsevier Science Publishers, Amsterdam, The Netherlands (1986).Applicant
• Chater et al., In: Sixth International Symposium on Actinomycetales Biology, Akademiai Kaido, Budapest, Hungary, pp. 45-54 (1986).Applicant
• Chen and Okayama, “High-Efficiency Transformation of Mammalian Cells by Plasmid DNA,” Molecular and Cellular Biology 7(8):2745-2752 (1987).Applicant
• Chomczynski and Sacchi, “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction,” Analytical Biochemistry 162:156-159 (1987).Applicant
• Chu et al., “Electroporation for the efficient transfection of mammalian cells with DNA,” Nucleic Acids Research 15:1311-1326 (1987).Applicant
• Courjal et al., “DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours,” British Journal of Cancer 74:1984-1989 (1996).Applicant
• Cowley et al., “Activation of MAP Kinase Kinase Is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells,” Cell 77:841-852 (1994).Applicant
• Curiel et al., “Gene Transfer to Respiratory Epithelial Cells via the Receptor-mediated Endocytosis Pathway,” Am. J. Respir. Cell. Mol. Biol. 6:247-252 (1992).Applicant
• Curtin et al., “Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717,” Br. J. Cancer 53:361-368 (1986).Applicant
• Dolle et al., “5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a Potent and Selective Inhibitor of Human Vascular -Type Platelet-Derived Growth Factor Receptor Tyrosine Kinase,”J. Med. Chem. 37:2627-2629 (1994).Applicant
• Dong et al., “Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity,” Journal of Leukocyte Biology 53:53-60 (1993).Applicant
• Dong et al., “Protein Tyrosine Kinase Inhibitors Decrease Induction of Nitric Oxide Synthase Activity in Lipopolysaccharide-Responsive and Lipopolysaccharide-Nonresponsive Murine Macrophages,” The Journal of Immunology 151(5):2717-2724 (1993).Applicant
• Elledge, “Cell Cycle Checkpoints: Preventing an Identity Crisis,” Science 274:1664-1672 (1996).Applicant
• Engvall and Perlmann, “Enzyme-Linked Immunosorbent Assay, ELISA. III. Quantitation of Specific Antibodies by Enzyme-Labeled Anti-Immunoglobulin in Antigen-Coated Tubes,” J. Immunology 109:129-135 (1972) (mistakenly referred to as Engval).Applicant
• Felgner and Ringold, “Catonic liposome-mediated transfection,” Nature 337:387-388 (1989).Applicant
• Felgner et al., “Lipofection: A Highly Efficient, Lipid-mediated DNA-transfection Procedure,” Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).Applicant
• Fernandes et al., “Biochemical and Antitumor Effects of 5,8-Dideazaisopteroylglutamate, a Unique Quinazoline Inhibitor of Thymidylate Synthase,” Cancer Research 43:1117-1123 (1983).Applicant
• Ferris et al., “Synthesis of Quinazoline Nucleosides from Ribose and Anthranilonitrile. Application of Phase-Transfer Catalysis in Nucleoside Synthesis,” J. Org. Chem. 44(2):173-178 (1979).Applicant
• Francisco et al., “Type 1 Protein Phosphatase Acts in Opposition to IPI1 Protein Kinase in Regulating Yeast Chromosome Segregation,” Molecular and Cellular Biology 14(7):4731-4740 (1994).Applicant
• Fry et al., “A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase,” Science 265:1093-1095 (1994).Applicant
• Gazit et al., “Tyrphostins 1. Synthesis and Biological Activity of Protein Tyrosine Kinase Inhibitors,” J. Med. Chem. 32:2344-2352 (1989).Applicant
• Gazit et al., “Tyrphostins. 3. Structure-Activity Relationship Studies of a -Substituted Benzylidenemalononitrile 5-S-Aryltyrphostins,” J. Med. Chem. 36:3556-3564 (1993).Applicant
• Malone et al., Focus 11, 66 (1989).Applicant
• Gilman et al., “Isolation of sigma-28-specific promoters from Bacillus subtilis DNA,” Gene 32:11-20 (1984).Applicant
• Glick and Whitney, “Factors affecting the expression of foreign proteins in Escherichia coli,” Journal of Industrial Microbiology 1:277-282 (1987).Applicant
• Glover et al., “Mutations in aurora Prevent Centrosome Separation Leading to the Formation of Monopolar Spindles,” Cell 81:95-105 (1995).Applicant
• Goding, “Conjugation of Antibodies with Fluorochromes: Modifications to the Standard Methods,” J. Immunological Methods 13:215-226 (1976).Applicant
• Gold et al., “Translational Initiation in Prokaryotes,” Ann. Rev. Microbiol. 35:365-403 (1981).Applicant
• Gopalan et al., “A Novel Mammalian, Mitotic-Spindle-associated Kinase is Related to Yeast and Fly Chromosome Segregation Regulators,” J. Cell. Biol. 138:643-656 (1997).Applicant
• Gottesman, “Bacterial Regulation: Global Regulatory networks,” Ann. Rev. Genet. 18:415-441 (1984).Applicant
• Gryczan, “Ch. 10—Molecular Cloning in Bacillus subtilis,” in The Molecular Biology of the Bacilli, edited by Dubnau, Academic Press, New York, pp. 307-329 (1982).Applicant
• Hammer and Walling, “Regulation In Vivo of a Cloned Mammalian Gene: Cadmium Induces the Transcription of a Mouse Metallothionein Gene in SV40 Vectors,” J. of Molecular and Applied Genetics 1:273-288 (1982).Applicant
• Hammer et al., “Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 and Human B2m: An Animal Model of HLA-B27-Associated Human Disorders,” Cell 63:1099-1112 (1990).Applicant
• Hartwell and Kastan, “Cell Cycle Control and Cancer,” Science 266:1821-1828 (1994).Applicant
• Houdebine and Chourrout, “Trangenesis in Fish,” Experientia 47:891-897 (1991).Applicant
• Hunter, “Oncoprotein Networks,” Cell 88:333-346 (1997).Applicant
• Hurby et al., “Application of Synthetic Peptides: Antisense Peptides,” In Synthetic Peptides, A User's Guide, W.H. Freeman, NY pp. 289-307 (1992), Grant G. (ed.).Applicant
• Innis et al., PCR Protocols: A Guide to Methods and Applications, edited by Michael A. Innis et al., Academic Press, San Diego (1990) (Table of Contents Only).Applicant
• Isola et al., “Genetic Aberrations Detected by Comparative Genomic Hybridization Predict Outcome in Node-Negative Breast Cancer,” American Journal of Pathology 147:905-911 (1995).Applicant
• Iwabuchi et al., “Genetic Analysis of Benign, Low-Grade, and High Grade Ovarian Tumors,” Cancer Research 55:6172-6180 (1995).Applicant
• Izaki, Japanese Journal of Bacteriology 33(6):729-742 (1978).Applicant
• Jackman, “ICI D1694, a Quinazoline Antifolate Thymidylate Synthase Inhibitor That Is a Potent Inhibitor of L1210 Tumor Cell Growth in Vitro and in Vivo: A New Agent for Clinical Study,” Cancer Research 51:5579-5586 (1991).Applicant
• Jakoby and Wilchek (editors), Affinity Techniques: Enzyme Purification: Part B, Methods in Enzymology, vol. XXXIV, Academic Press, New York (1974) (Table of Contents Only).Applicant
• James et al., “Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma,” Oncogene 14:1059-1065 (1997).Applicant
• Jasny, “Insect Viruses Invade Biotechnology,” Science 238:1653 (1987).Applicant
• John and Twitty, “Plasmids as Epidemiologic Markers in Nosocomial Gram-Negative Bacilli: Experience at a University and Review of the Literature,” Reviews of Infectious Diseases 8:693-704 (1986).Applicant
• Johnston and Hopper, “Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon,” Proc. Natl. Acad. Sci. USA 79:6971-6975 (1982).Applicant
• Jones et al., “Quinazoline Antifolates Inhibiting Thymidylate Synthase: Varation of the Amino Acid,” J. Med. Chem. 29:1114-1118 (1986).Applicant
• Joyner et al., “Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells,” Nature 338:153-156 (1989).Applicant
• Kallioniemi et al., “Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization,” Proc. Natl. Acad. Sci. USA 91:2156-2160 (1994).Applicant
• Kasprzak et al., “Location of a Contact Site Between Actin and Myosin in the Three-Dimensional Structure of the Acto-S1 Complex,” Biochemistry 28:9230-9238 (1989) (also referred to as Kaspczak).Applicant
• Kaur, “Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia,” Anti-Cancer Drugs 5:213-222 (1994).Applicant
• Kendall and Cohen, “Plasmid Transfer in Streptomyces lividans: Identification of a kil-kor System Associated with the Transfer Region of PIJ101,” Journal of Bacteriology 169:4177-4183 (1987).Applicant
• Kimura et al., “Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ip11,” J. Biol. Chem. 272:13766-13771 (1997).Applicant
• King et al., “Site-specific dephosphorylation and deactivation of the human insulin receptor tyrosine kinase by particulate and soluble phosphotyrosyl protein phosphatases,” Biochem. J. 275:413-418 (1991).Applicant
• Kinzler and Vogelstein, “Cancer-susceptibility Genes: Gatekeepers and caretakers,” Nature 386:761-763 (1997).Applicant
• Köhler (Kohler) and Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,” Nature 256:495-497 (1975).Applicant
• Kuo et al., “Effects of signalling transduction modulators on the transformed phenotypes in v-H-ras-transformed NIH 3T3 cells,” Cancer Letters 74:197-202 (1993).Applicant
• Larramendy et al., “Gains, Losses, and Amplifications of DNA Sequences Evaluated by Comparative Genomic Hybridization in Chondrosarcomas,” American Journal of Pathology 150:685-691 (1997).Applicant
• Lee and Skibo, “Active-Site-Directed Reductive Alkylation of Xanthine Oxidase by Imidazo[4,5-g]quinazoline-4,9-diones Functionalized with a Leaving Group,” Biochemistry 26:7355-7362 (1987).Applicant
• Lemus et al., “Studies of Extended Quinone Methides. Synthesis and Physical Studies of Purine-like Monofunctional and Bifunctional Imidazo[4,5-g]quinazoline Reductive Alkylating Agents,” J. Org. Chem. 54:3611-3618 (1989).Applicant
• Levitzki, “Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction,” FASEB J. 6:3275-3282 (1992).Applicant
• Ley and Seng, “Synthesis Using Benzofuroxan,” Synthesis 1975:415-422 (1975).Applicant
• Lui et al., “Construction of a GAL1-Regulated Yeast cDNA Expression Library and its Application to the Identification of Genes Whose Overexpression Causes Lethality in Yeast,” Genetics 132:665-673 (1992).Applicant
• Lutz et al., “The Distribution of Two hnRNP-Associated Proteins Defined by a Monoclonal Antibody Is Altered in Heat-Shocked HeLa Cells,” Experimental Cell Research 175:109-124 (1988).Applicant
• Lyall et al., “Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-stimulated Cell Proliferation,” J. Biol. Chem. 264:14503-14509 (1989).Applicant
• Burke, et al. J. Med. Chem., 36:425-432 (1993).Applicant
• Maniatis, In:Cell Biology: A Comprehensive Treatise, vol. 3, Gene Sequence Expression, Academic Press, NY, pp. 563-608 (1980).Applicant
• Markowitz et al., “Construction and Use of a Safe and Efficient Amphotropic Packaging Cell Line,” Virology 167:400-406 (1988).Applicant
• Maxwell et al., “19F Nuclear Magnetic Resonance Imaging of Drug Distribution in Vivo: The Diposition of an Antifolate Anticancer Drug in Mice,” Magnetic Resonance in Medicine 17:189-196 (1991).Applicant
• McKnight, “Functional Relationships between Transcriptional Control Signals of the Thymidine Kinase Gene of Herpes Simplex Virus,” Cell 31:355-365 (1992).Applicant
• Miller and Rosman, “Improved Retroviral Vectors for Gene Transfer and Expression,” BioTechniques 7(9):980-990 (1989).Applicant
• Miller et al., In: Genetic Engineering, vol. 8, Plenum, Setlow et al., eds., pp. 277-297 (1986).Applicant
• Miller, “Human gene therapy comes of age,” Nature 357:455-460 (1992).Applicant
• Mini et al., “Cytotoxic Effects of Folate Antagonists against Methotrexate-resistant Human Leukemic Lymphoblast CCRF-CEM Cell Lines,” Cancer Research 45:325-330 (1985).Applicant
• Mitelman et al, Nature Genet., 15:417-474 (1997).Applicant
• Mossie et al., “Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family,” Oncogene 11(10):2179-2184 (1995).Applicant
• Muleris et al., “Characteristic Chromosomal Imbalances in 18 Near-Diploid Colorectal Tumors,” Cancer Genet Cytogenet 29:289-301 (1987).Applicant
• Mulligan, “The Basic Science of Gene Therapy,” Science 260-926-932 (1993).Applicant
• Nelson, “Detection of Acridinium Esters by Chemiluminescence,” Nonisotopic DNA Probe Techniques, ed. Larry J. Kricka, (San Diego:Academy Press, Inc.) pp. 275-310 (1992) (Table of Contents Only).Applicant
• Okayama and Berg, “A cDNA Cloning Vector That Permits Expression of cDNA Inserts in Mammalian Cells,” Molecular and Cellular Biology 3:280-289 (1983).Applicant
• Pati, “Novel vectors for expression of cDNA encoding epitope-tagged proteins in mammalian cells,” Gene 114:2856-288 (1992).Applicant
• Peterson and Barnes, “Genistein and Biochanin A Inhibit the Growth of Human Prostate Cancer Cells but not Epidermal Growth Factor Receptor Tyrosine Autophosphorylation,” The Prostate 22:335-345 (1993).Applicant
• Phillips and Castle, “Quino[1,2-c]quinazolines. I. Synthesis of Quino[1,2-c]quinazolinium Derivatives and the Related Indazolo[2,3-a]quinoline Derivatives as Analogs of the Antitumor Benzo[c]phenanthridine Alkaloids,” J. Heterocyclic Chemistry 17:1489-1496 (1980).Applicant
• Pillemer et al., “Insulin Dependence of Murine Lymphoid T-Cell Leukemia,” Brit. J. Cancer 50:80-85 (1992).Applicant
• Posner et al., “Kinetics of inhibition by Tyrphostins of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor and Analysis by a New Computer Program,” Molecular Pharmacology 45:673-683 (1993).Applicant
• Pursel et al., “Genetic Engineering of Livestock,” Science 244:1281-1288 (1989).Applicant
• Redemann et al., “Anti-Oncogenic Activity of Signalling-Defective Epidermal Growth Factor Receptor Mutants,” Molecular and Cellular Biology 12(2):491-498 (1992).Applicant
• Reece et al., “Pharmacokinetics of Trimetrexate Administered by Five-Day Continuous Infusion to Patients with Advanced Cancer,” Cancer Research 47:2996-2999 (1987).Applicant
• Rendu et al., “Inhibition of Platelet Activation by Tyrosine Kinase Inhibitors,” Biochemical Pharmacology 44(5):881-888 (1992).Applicant
• Reznikoff et al., “A Molecular Genetic Model of Human Bladder Cancer Pathogenesis,” Seminars in Oncology 23:571-584 (1996).Applicant
• Robertson, E.J., ed., Teratocarcinomas and Embryonic Stem Cells, A Practical Appraoch, IRL Press (1987).Applicant
• Roghi et al., “Xenopus laevis mRNA encoding protein kinase,” EMBL Sequence Database, Heidelberg, Brd., XP002029130, accession No. Z17206, Jan. 1, 1995.Applicant
• Roghi et al., “Xenopus laevis mRNA encoding protein kinase,” EMBL Sequence Database, Heidelberg, Brd., XP002029131, accession No. Z17207, Jan. 1, 1995.Applicant
• Rubin, “Drosophila melanogaster as an Experimental Organism,” Science 240:1453-1459 (1988).Applicant
• Sambrook, Fritsch & Maniatis, eds., Molecular Cloning: A Laboratory Manual, second edition, Cold Spring Harbor Laboratory (1989).Applicant
• Sauro and Thomas, “Decreased Sensitivity of Aorta from Hypertensive Rats to Vasorelaxation by Tyrphostin,” Life Sciences 53:PL371-376 (1993).Applicant
• Sauro and Thomas, “Tyrphostin Attenuates Platelet-Derived Growth Factor-Induced Contraction in Aortic Smooth Muscle Through Inhibition of Protein Tyrosine Kinase(s),” The Journal of Pharmacology and Experimental Therapeutics 267:1119-1125 (1993).Applicant
• Savelieva et al., “20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells,” Oncogene 14:551-560 (1997).Applicant
• Schlegel et al., “Comparative Genomic in Situ Hybridization of Colon Carcinomas with Replication Error,” Cancer Research 55:6002-6005 (1995).Applicant
• Sculier et al., “Role of an Intensive Care Unit (ICU) in a Medical Oncology Department,” Cancer Immunol. and Immunotherapy 23:A65 at abstract No. 257 (1986).Applicant
• Sen et al., “A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines,” Oncogene 14:2195-2200 (1997).Applicant
• Sherr, “Cancer Cell Cycles,” Science 274:1672-1677 (1996).Applicant
• Sikora and Grzelakowska-Sztabert, “Quinazoline CB 3717 and CB 3703 Inhibitors of Folate Retention and Metabolism in Ehrlich Ascites Carcinoma Cells and Some Organs of the Host-Mouse,” Cancer Letters 23:289-295 (1984).Applicant
• Sikora et al., “Development of an Assay for the Estimation of N10-Propargyl-5,8-dideazafolic Acid Polyglutamates in Tumor Cells,” Analytical Biochemistry 172:344-355 (1988).Applicant
• Silver et al., “Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization,” Proc. Natl. Acad. Sci. USA 81:5951-5955 (1984).Applicant
• Simons et al., “Gene Transfer into Sheep,” Bio/Technology 6:179-182 (1988) (also referred to as Simms or Simmons).Applicant
• Solinas-Toldo et al., “Mapping of Chromosomal Imbalances in Pancreatic Carcinoma by Comparative Genomic Hybridization,” Cancer Research 56:3803-3807 (1996).Applicant
• Southern, “Detection of Specific Sequences Among DNA Fragments Separated byGel Electrophoresis,” J. Mol. Biol. 98:503-517 (1975).Applicant
• St. Groth and Scheidegger, “Production of Monoclonal Antibodies: Strategy and Tactics,” J. Immunol. Methods 35:1-21 (1980).Applicant
• Sternberger et al., “The Unlabeled Antibody Enzyme Method of Immunohistochemistry: Preparation and Properties of Soluble Antigen-Antibody Complex (Horseradish Peroxidase-Antihorseradish Peroxidase) and Its Use in Identification of Spirochetes,” J. Histochemistry and Cytochemistry 18(5):315-333 (1970) (mistakenly referred to as Stemberger).Applicant
• Tabor et al., “DNA sequence analysis with a modified bacteriophage T7 DNA polymerase,” Proc. Natl. Acad. Sci. USA 84:4767-4771 (1987).Applicant
• Tanner et al., “Increased Copy Number at 20q13 in Breast Cancer: Defining the Critical Region and Exclusion of Candidate Genes,” Cancer Research 54:4257-4260 (1994).Applicant
• Tanner et al., “Independent Amplification and Frequent Co-Amplification of Three Nonsyntenic Regions on the Long Arm of Chromosome 20 in Human Breast Cancer,” Cancer Research 56:3441-3445 (1996).Applicant
• Tijssen, “Practice and Theory of Enzyme Immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology,” Elsevier Science Publishers, Amsterdam, The Netherlands (1985).Applicant
• Tirkkonen et al., “Distinct Somatic Genetic Changes Associated with Tumor Progression in Carriers of BRCA1 and BRCA2 Germ-line Mutations,” Cancer Research 57:1222-1227 (1997).Applicant
• Ulmanen et al., “Transcription and Translation of Foreign Genes in Bacillus subtilis by the Aid of a Secretion Vector,” Journal of Bacteriology 162:176-182 (1985).Applicant
• Ward et al., “Construction and characterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator,” Mol. Gen. Genet. 203:468-478 (1986).Applicant
• Weir (eds), “Ch. 10—The chemistry and standardization of allergens,” in Handbook of Experimental Immunology—Volume 1: Immunochemistry, 4th Ed., edited by Weir et al., Blackwell Scientific Publications, Oxford, England, pp. 10.1-10.28 (1986).Applicant
• Wolbring et al., “Inhibition of GTP-utilizing Enzymes by Tyrphostins,” J. Biol. Chem. 269:22470-22472 (1994).Applicant
• Wolf et al., “Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer,” Oncogene 14:543-549 (1997).Applicant
• Yanai et al., “ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis,” Oncogene 14:2943-2950 (1997).Applicant
• Yang et al., “In Vivo and In Vitro Gene Transfer to Mammalian Somatic Cells by Particle Bombardment,” Proc. Natl. Acad. Sci. USA 87:9568-9572 (1990).Applicant
• Yaseen et al., “Chromosome Studies in Eleven Colorectal Tumors,” Cancer Genet Cytogenet 44:83-97 (1990).Applicant
• Yoneda et al., “The Antiproliferative Effects of Tyrosine Kinase Inhibitors Tyrphostins on a Human Squamous Cell Carcinoma in Vitro and in Nude Mice,” Cancer Research 51:4430-4435 (1991).Applicant
• Tung et al., Molecular and cellular Biology, 15(11), 6064-6074, Nov. 1995.Applicant
• Kimura et al., “Molecular cloning of a human homolog of Aurora, a serine/threonine kinase which regulates the chromosome segregation,” Nippon Bunshi Seibutsu Gakkai Nenkai Puroguramu, vol. 18, pp. 497, Abst. 3P-205 (1995).Applicant