Implantable system with drug-eluting cells for on-demand local drug delivery

Patent Citations (61)

Non-Patent Literature (68)

• Albert, □Laser Angioplasty and Intracoronary Stents: Going Beyond the Balloon,□ AACN Clinical Issues, 5(1), 15-20 (1994).Applicant
• Bailie et al., □Vascular-Access-Port Implantation for Serial Blood Sampling in Conscious Swine,□ Laboratory Animal Science, 36(4), 431-433, table of contents (1986).Applicant
• Bansal et al., □Calcium-Regulated Secretion of Tissue Plasminogen Activator and Parathyroid Hormone from Human Parathyroid Cells,□ Journal of Clinical Endocrinology and Metabolism, 74(2), 266-271 (1992).Applicant
• Barbee et al., □Retroviral Suicide Vector Does Not Inhibit Neointimal Growth In A Porcine Coronary Model of Restenosis,□ Biochem. Biophys. Res. Comm., 207(1), 89-98 (1995).Applicant
• Barinaga □Gene Therapy for Clogged Arteries Passes Tests in Pigs,□ Science, 265, 738 (1994).Applicant
• Biomedical Business International, 18(9), 163 (1995).Applicant
• Blaese et al., □T Lymphocyte-Directed Gene Therapy for ADA-SCID: Initial Trial Results After 4 Years,□ Science, 270, 475-480 (1995).Applicant
• Bordignon et al., □Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA-Immunodeficient Patients,□ Science, 270, 470-475 (1995).Applicant
• Bouaziz et al., □Effect of constant and modulated electrical charges applied to the culture material on PGI2 and TXA2 secretion by endothelial cells,□ Biomaterials, 16(9), 727-734 (1995).Applicant
• Bouaziz et al., □Vascular endothelial cell responses to different electrically charged poly(vinylidene fluoride) supports under static and oscillating flow conditions,□ Biomaterials, 18, 107-112 (1997).Applicant
• Braunwald et al., □Unstable Angina: Diagnosis and Management,□ Clinical Practical Guidelines, No. 10, U.S. Department of Health and Human Services, 27-92 (1994).Applicant
• Bugiardini et al., □Relation of Severity of Symptoms of Transient Myocardial Ischemia and Prognosis in Unstable Angina,□ JACC, 25(3), 597-604 (1995).Applicant
• Carmeliet et al., □Gene targeting and gene transfer studies of the plasminogen/plasmin system: implications in thrombosis, hemostasis, neointima formation, and atherosclerosis,□ FASEB, 9, 934-938 (1995).Applicant
• Chang et al., □Adenovirus-mediated Over-expression of the Cyclin/Cyclin-dependent Kinase Inhibitor, p21 Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation in the Rat Carotid Artery Model of Balloon Angioplasty,□ J. Clin. Invest., 96, 2260-2268 (1995).Applicant
• Chang et al., □Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active Form of the Retinoblastoma Gene Product,□ Science, 267, 518-522 (1995).Applicant
• Chapman et al., □Gene Transfer Into Coronary Arteries of Intact Animals With a Percutaneous Balloon Catheter,□ Circ. Research, 71(1), 27-33 (1992).Applicant
• Chowdhury et al., □Long-Term Improvement of Hypercholesterolemia After ex Vivo Gene Therapy in LDLR-Deficient Rabbits,□ Science, 254, 1802-1805 (1991).Applicant
• Cotten et al., □High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles,□ Proc. Natl. Acad. Sci. USA, 89(13), 6094-6098 (1992).Applicant
• Dalesandro et al., □Cardiac and Pulmonary Replacement,□ The Journal of Thoracic and Cardiovascular Surgery, 111(2), 416-422 (1996).Applicant
• Dichek et al., □Enhanced In Vivo Antithrombotic Effects of Endothelial Cells Expressing Recombinant Plasminogen Activators Transduced With Retroviral Vectors,□ Circulation, 93(2), 301-309 (1996).Applicant
• Dichek, □Retroviral Vector-mediated Gene Transfer into Endothelial Cells,□ Mol. Biol. Med., 8, 257-266 (1991).Applicant
• Dichek et al., □Seeding of Intravascular Stents With Genetically Engineered Endothelial Cells,□ Circulation, 80(5), 1347-1353 (1989).Applicant
• Dunn et al., □Seeding of Vascular Grafts With Genetically Modified Endothelial Cells,□ Circulation, 93(7), 1439-1446 (1996).Applicant
• Dzau et al., □Gene therapy for cardiovascular disease,□ Tibtech, 11, 205-210 (1993).Applicant
• Ekhterae et al., □Retroviral vector-mediated transfer and expression of human tissue plasminogen activator gene in human endolthelial and vascular smooth muscle cells,□ Journal of Vascular Surgery, 21(6), 953-962 (1995).Applicant
• Fisher et al., □Isolation and Characterization of the Human Tissue-type Plasminogen Activator Structural Gene Including Its 5′ Flanking Region,□ The Journal of Biological Chemistry, 260(20), 11223-11230 (1985).Applicant
• Flugelman et al., □Inhibition of Intravascular Thrombosis and Vascular Smooth Muscle Cell Proliferation by Gene Therapy,□ F.K. Schattauer Verlagsgesellschaft mbH (Stuttgart), 74(1), 406-410 (1995).Applicant
• French et al., □Persistence of Luciferase Gene Expression Following Adenovirus-Mediated In Vivo Direct Gene Transfer Into Porcine Coronary Arteries,□ Journal of Cellular Biochemistry, 18A, 241 (1994).Applicant
• Gillis et al., □Secretion of Prostacyclin, Tissue Plasminogen Activator and its Inhibitor by Cultured Adult Human Endothelial Cells Grown on Different Matrices,□ Eur. J. Vasc. Endovasc. Surg., 11, 127-133 (1996).Applicant
• Grossman et al., □Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia,□ Nature Genetics, 6, 335-341 (1994).Applicant
• Holmes, Jr., et al., □Polymeric Stenting in the Porcine Coronary Artery Model: Differential Outcome of Exogenous Fibrin Sleeves Versus Polyurethane-Coated Stents,□ JACC, 24(2), 525-531 (1994).Applicant
• Innis et al., □PCR Strategies,□ Academic Press, New York, New York, cover page and table of contents (1995).Applicant
• Kohn, et al., □Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency,□ Nature Medicine, 1(10), 1017-1023 (1995).Applicant
• Kaneda et al., □Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver,□ Science, 243, 375-378 (1989).Applicant
• Kaneda et al., □Introduction and Expression of the Human Insulin Gene in Adult Rat Liver,□ The Journal of Biological Chemistry, 264(21), 12126-12129 (1989).Applicant
• Kato et al., □Expression of Hepatitis B Virus Surface Antigen in Adult Rat Liver,□ The Journal of Biological Chemistry, 266(6), 3361-3364 (1991).Applicant
• Lafont et al., □Which gene for which restenosis,□ The Lancet, 346, 1442 (1995).Applicant
• Landau et al., □Adenoviral mediated gene transfer to atherosclerotic arteries after balloon angioplasty,□ American Heart Journal, 129(6), 1051-1057 (1995).Applicant
• Levin et al., □Protein Kinase C and the Stimulation of Tissue Plasminogen Activator Release from Human Endothelial Cells,□ The Journal of Biological Chemistry, 264(27), 16030-16036 (1989).Applicant
• Lilly, □Acute Myocardial Infarction,□ Pathophysiology of Heart Disease, Lea & Febiger, Philadelphia, PA, Ch. 7, 113-129 (1993).Applicant
• Lincoff et al., □Intracoronary Stenting Compared With Conventional Therapy for Abrupt Vessel Closure Complicating Coronary Angioplasty: A Matched Case-Control Study,□ JACC, 21(4), 866-875 (1993).Applicant
• Lincoff et al., □Local Drug Delivery for the Prevention of Restenosis,□ Circulation, 90(4), 2070-2084 (1994).Applicant
• Mann et al., □Genetic engineering of vein grafts resistant to atherosclerosis,□ Proc. Natl. Acad. Sci. USA, 92, 4502-4506 (1995).Applicant
• Mazur et al., □Coronary Restenosis and Gene Therapy,□ Texas Heart Institute J., 21, 104-111 (1994).Applicant
• Mazur et al., □Replication-Deficient Adenoviral Vectors Mediate Efficient Direct In Vivo Gene Transfer into Normal and Injured Porcine Coronary Arteries,□ Gene Therapy, 243, DZ 410.Applicant
• Morishita et al., □Novel and Effective Gene Transfer Technique for Study of Vascular Renin Angiotensin System,□ J. Clin. Invest., 91, 2580-2585 (1993).Applicant
• Nabel et al., □Recombinant Gene Expression in Vivo Within Endothelial Cells of the Arterial Wall,□ Science, 244, 1342-1344 (1989).Applicant
• Nilius et al., □Activation of a C1-Current by Hyptonoic Volume Increase in Human Endothelial Cells,□ J. Gen. Physiol., 103, 787-805 (1994).Applicant
• Ohno et al., □Gene Therapy for Vascular Smooth Muscle Cell Proliferation After Arterial Injury,□ Science, 265, 781-784.Applicant
• Qin et al., □Multiple Vectors Effectively Achieve Gene Transfer In A Murine Cardiac Transplantation Model,□ Transplantation, 59(6), 809-816 (1995).Applicant
• Ryan et al., □ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction,□ J. Am. Coll. Cardiol., 28(5), 1328-1428 (1996).Applicant
• Sambrook et al., □Molecular Cloning: A Laboratory Manual,□ Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, cover page and table of contents (1989).Applicant
• Santell et al., □Cyclic AMP Potentiates Phorbol Ester Stimulation of Tissue Plasminogen Activator Release and Inhibits Secretion of Plasminogen Activator Inhibitor-1 from Human Endothelial Cells,□ The Journal of Biological Chemistry, 263(32), 16802-+16808 (1988).Applicant
• Sawa et al., □Efficiency of In Vivo Gene Transfection Into Transplanted Rat Heart by Coronary Infusion of HVJ Liposome,□ American Heart Assoc. Suppl. To Circulation, 92(9), 479-482 (1995).Applicant
• Smela et al., □Controlled Folding of Micrometer-Size Structures,□ Science, 268, 1735-1738 (1995).Applicant
• Soldani et al., □Bioartificial polymeric materials obtained from blends of synthetic polymers with fibrin and collagen,□ The International Journal of Artificial Organs, 14(5), 295-303 (1991).Applicant
• Steg et al., □Arterial Gene Transfer to Rabbit Endothelial and Smooth Muscle Cells Using Percutaneous Delivery of an Adenoviral Vector,□ Circulation, 90, 1648-1656 (1994).Applicant
• Stephan et al., □A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo,□ Human Gene Therapy, 7, 1803-1812 (1996).Applicant
• Tanguay et al., □Current State of Biodegradable Stents,□ Contemporary Interventional Techniques, 12(4), 699-713 (1994).Applicant
• Van Beusekom et al., □Synthetic polymers as an alternative to metal in stents ? In vivo and mechanical behaviour of polyethylene-terephtalate,□ American Heart Association Supplement to Circulation, 86(4), 731 (1992).Applicant
• Van Den Eijnden-Schrauwen et al., □Studies on the Acute Release of Tissue-Type Plasminogen Activator From Human Endothelial Cells In Vitro and in Rats in Vivo: Evidence for a Dynamic Storage Pool,□ Blood, 95(12), 3510-3517 (1995).Applicant
• Van Leusden, □Premenstrual syndrome no progesterone; premenstrual dysphoric disorder no serotonin deficiency,□ 346, 1443 (1995).Applicant
• Williams et al., □Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse,□ Nature, 310, 476-480 (1984).Applicant
• Yanagisawa et al., □The Human Preproendothelin-1 Gene: Possible Regulation by Endothelial Phosphoinositide Turnover Signaling,□ Journal of Cardiovascular Pharmacology, 13(Supp. 5), S13-S17 (1989).Applicant
• Yang et al., □Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury,□ Proc. Natl. Acad. Scie. USA, 93, 7905-7910 (1996).Applicant
• Nabel, “Gene Therapy for Cardiovascular Disease,” American Heart Association, Inc. (1995).Applicant
• PCT International Search Report for PCT/US 99/18719, 23/08/99, Medtronic, Inc., Docket No. P7417.03.Applicant
• PCT International Search Report for PCT/US 99/09228, 28/04/99, Medtronic, Inc., Docket No. P7417.02.Applicant