Compositions and methods using complexes of heat shock protein 90 and antigenic molecules for the treatment and prevention of infectious diseases

Patent Citations (42)

Non-Patent Literature (83)

• Aldovini et al. (1992) “The New Vaccines”, Technology Review pp. 24-31.Applicant
• Barrios et al. (1992) “Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines that can circumvent the need for adjuvants and Bacillus Calmette Gueérin priming”, Eur. J. Immunol. 22:1365-1372.Applicant
• Basombrio (1970) “Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene”, The Institute for Cancer Research 30:2-2462.Applicant
• Blachere et al. (1993) “Heat Shock Protein Vaccines Against Cancer,” Journal of Immunotherapy 14:352-356.Applicant
• Blachere and Srivastava (1993) “Immunization with GP96 heat shock proteins isolated from tumors or influenza virus infected cells elicits MHC-restricted, antigen-specific cytotoxic T lymphocytes against the corresponding cells”, J. Cellular Biochem. Keystone Symposia NZ502, p. 124.Applicant
• Boon, (1992) “Toward a genetic analysis of tumor rejection antigens”, Advances in Cancer Research 58:177-210.Applicant
• Cohen (1993) “Cancer Vaccines Get A Shot In The Arm”, Science 262:841-843.Applicant
• Craig (1993) “Chaperones: Helpers Along the Pathways to Protein Folding”, Science 260:1902-1904.Applicant
• Elliott et al. (1990) “Naturally Processed Peptides”, Nature 348:195-197.Applicant
• Falk et al. (1991) “Allele-specific Motifs Revealed by Sequencing of Self-peptides Eluted from MHC Molecules”, Nature 351:290-296.Applicant
• Falk et al. (1990) “Cellular Peptide Composition Governed by Major Histocompatibility Complex Class I Molecules”, Nature 348:248-251.Applicant
• Fedweg and Srivastava, (1993) “Evidence for biochemical heterogeneity of gp96 heat shock protein/tumor rejecion antigen”, J. Cellular Biochem. Supp. 17D NZ 206, p. 108.Applicant
• Flynn et al. (1989) “Peptide binding and release by proteins implicated as catalysts of protein assembly”, Science 245:385-390.Applicant
• Flynn et al. (1991) “Peptide-binding Specificity of the Molecular Chaperone BiP”, Nature 353:726-730.Applicant
• Franklin (1993) “Making vaccines fit the cancer”, New Scientist 140:17.Applicant
• Gething et al. (1992) “Protein Folding in the Cell”, Nature 355:33-45.Applicant
• Globerson and Feldman (1964) “Antigenic specificity of benzo[a]pyrene-induced sarcomas”, Journal of the National Cancer Institute 32(6):1229-1242.Applicant
• Jakob et al. (1993) “Small Heat Shock Proteins Are Molecular Chaperones”, J. Biol. Chem. 268:1517-1520.Applicant
• Jardetzky et al. (1991) “Identification of Self Peptides Bound to Purified HLA-B27”, Nature 353:326-329.Applicant
• Lakey et al (1987) “Identification of a peptide binding protein that plays a role in antigen presentation”, Proc. Natl. Acad. Sci. USA 84:1659-1663.Applicant
• Lanzavecchia (1993) “Identifying Strategies for Immune Intervention”, Science 260:937-944.Applicant
• Lévy (1991) “ATP is Required for In Vitro Assembly of MHC Class I Antigens but Not for Transfer of Peptides across the ER Membrane”, Cell 67:265-274.Applicant
• Li and Srivastava (1993) “Tumor rejection antigen gp96/grp94 is an ATPase: Implications for protein folding and antigen presentation”, EMBO J. 12(8):3143-3151.Applicant
• Lindquist and Craig (1988) “The heat-shock proteins”, Ann. Rev. Genet. 22:631-677.Applicant
• Luescher et al. (1991) “Specific Binding of Antigenic Peptides to Cell-associated MHC Clas I Molecules”, Nature 351:72-77.Applicant
• Lukacs et al. (1993) “Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors”, J. Exp. Med. 178:343-348.Applicant
• Lussow et al. (1991) “Mycobacterial heat-shock proteins as carrier molecules”, Eur. J. Immunol. 21:2297-2302.Applicant
• Madden et al. (1991) “The Structure of HLA-B27 Reveals Nonamer Self-peptides Bound in an Extended Conformation”, Nature 353:321-325.Applicant
• Maki et al. (1993) “Mapping of the Genes for Human Endoplasmic Reticular Heat Shock Protein gp96/grp94”, Somatic Cell Mol. Genetics 19(1):73-81.Applicant
• Maki et al. (1990) “Human homologue of murine tumor rejection antigen gp96: 5′-Regulatory and coding regions and relationship to stress-induced proteins”, Proc. Natl. Acad. Sci. USA 87:5658-5663.Applicant
• McCall et al. (1989) “Biotherapy: A New Dimension in Cancer Treatment”, Biotechnology 7:231-240.Applicant
• Melnick (1985) “Virus Vaccines: An Overview”, Proceedings of the First Annual Southwest Foundation for Biomedical Research International Symposium, Houston, Texas, Nov. 8-10, 1984, American Society for Microbiology pp. 1-13.Applicant
• Nelson et al. (1992) “The Translation Machinery and 70 kd Heat Shock Protein Cooperate in Protein Synthesis”, Cell 71:97-105.Applicant
• Palladino et al. (1987) “Expression of shared tumor-specific antigen by two chemically induced BALB/c sarcomas”, Cancer Research 47:5074-5079.Applicant
• Prehn and Main (1957) “Immunity to methylcholanthrene-induced sarcomas”, Journal of the National Cancer Institute 18(6):769-778.Applicant
• Rothman (1989) “Polypeptide Chain Binding Proteins: Catalysts of Protein Folding and Related Processes in Cells”, Cell 59:591-601.Applicant
• Rötzschke et al. (1990) “Isolation and Analysis of Naturally Processed Viral Peptides as Recognized by Cytotoxic T cells”, Nature 348:248-251.Applicant
• Salk et al. (1993) “A Strategy for Prophylactic Vaccination Against HIV”, Science 260:1270-1272.Applicant
• Schumacher et al. (1991) “Peptide Selection by MHC Class I Molecules”, Nature 350:703-706.Applicant
• Srivastava et al. (1991) “Protein Tumor Antigens”, Curr. Opin. Immunol. 3:654-658.Applicant
• Srivastava et al. (1984) “The Serologically Unique Cell Surface Antigen of Zajdela Ascitic Hepatoma is also its Tumor-Associated Transplantation Antigen”, Int. J. Cancer 33:417-422.Applicant
• Srivastava et al. (1989) “Identification of a Human Homologue of the Murine Tumor Rejection Antigen GP96,” Cancer Res. 49:1341-1343.Applicant
• Srivastava et al. (1988) “Individually Distinct Transplantation Antigens of Chemically Induced Mouse”, Immunology Today 9:78-83.Applicant
• Srivastava et al. (1988) “Chromosonal Assignment of the Gene Encoding the Mouse Tumor Rejection Antigen gp96”, Immunogenetics 28:205-207.Applicant
• Srivastava et al. (1987) “5′-Structural analysis of genes encoding polymorphic antigens of chemically induced tumors”, Proc. Natl. Acad. Sci. USA 84:3807-3811.Applicant
• Srivastava et al. (1993) “Peptide-Binding Heat Shock Proteins in the Endoplasmic Reticulum: Role in Immune Response to Cancer and in Antigen Presentation”, Advances in Cancer Research 62:153-177.Applicant
• Srivastava and Maki (1991) “Stress-induced proteins in immune response cancer”, Microbiol. Immunol. 167:109-123.Applicant
• Srivastava and Heike (1991) “Tumor-specific immunogenicity of stress-induced proteins: Convergence of two evolutionary pathways of antigen presentation?”, Seminars in Immunology 3:57-64.Applicant
• Srivastava et al. (1986) “Tumor rejection antigens of chemically induced sarcomas of inbred mice”, Proc. Natl. Acad. Sci. USA 83:3407-3411.Applicant
• Subbarao et al. (1992) “A General Overview of Viral Vaccine Development,” Genetically Engineered Vaccines 327:51-57.Applicant
• Szikora et al. (1990) “Structure of the gene of tum-transplantation antigen P35B presence of a point mutation in the agenic allele”, EMBO J. 9(4):1041-1050.Applicant
• Udono (1993) “Heat shock proteins HSP70, HSP90 and GP96 elicit tumor specific immunity to the tumors from which they are isolated”, J. Cell. Biochem. Suppl. 17D:113 (Abstract NZ225).Applicant
• Udono et al. (1993) “Heat Shock Protein 70-associated Peptides Elicit Specific Cancer Immunity”, J. Exp. Med. 178:1391-1396.Applicant
• Ullrich et al. (1986) “A mouse tumor-specific transplantation antigen is a heat shock-related protein”, Proc. Natl. Acad. Sci. USA 83:3121-3125.Applicant
• Vanbuskirk et al. (1989) “peptide binding protein having a role in antigen presentation is a member of the hsp70 heat shock family”, J. Exp. Med. 170:1799-1809.Applicant
• Welch et al. (1982), “Purification of the Major Mammalian Heat Shock Proteins”, J. Biol. Chem. 257:14949-14959.Applicant
• Welch et al. (1985) “Rapid Purification of Mammalian 70,000-Dalton Stress Proteins: Affinity of the Proteins for Nucleotides”, Mol. Cell. Biol. 5:1229-1237.Applicant
• Welch (1993) “How Cells Respond to Stress”, Scientific American pp. 56-64.Applicant
• Young (1990) “Stress Proteins and Immunology”, Annu. Rev. Immunol. 8:401-420.Applicant
• Yu et al. (1991) “Sequence Analysis of Peptides Bound to MHC Class II Molecules”, Nature 353:622-627.Applicant
• Blachere et al., 1993, “Immunization with GP96 heat shock proteins isolated from tumors or influenza virus infected cells elicits MHC-restricted, antigen-specific cytotoxic T lymphocytes against the corresponding cells/antigens”, J. Cell Biochem. Suppl. 17D:124 (Abstract NZ 502).Applicant
• Levinson et al., 1979 “Metal Binding Drugs Induce Synthesis of Four Proteins in Normal Cells”, Biol. Trace Element Research 1:15-23.Applicant
• Martin et al., 1986, “Role of Murine Tumor Models in Cancer Treatment Research”, Cancer Res. 46:2189-2192.Applicant
• Mulé et al., 1984, “Adoptive Immunotherapy of Established Pulmonary Metastases with LAK cells and Recombinant Interleukin-2”, Science 225: 1487-1489.Applicant
• Nieland et al., 1996, “Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94”, Proc. Natl. Acad. Sci. USA 93: 6135-6139.Applicant
• Srivastava et al., 1993, “Evidence for peptide-chaperoning by the endoplasmic reticular heat shock protein GP96: Implications for vaccination against cancer and infectious diseases”, J. Cell Biochem. Suppl. 17D:94 (Abstract NZ014).Applicant
• Suto, R. and Srivastava, P.K., 1995, “A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides”, Science 269: 1585-1588.Applicant
• Thomas et al., 1982, “Molecular and Cellular Effects of Heat Shock and Related Treatments of Mammalian Tissue-Culture Cells”, Cold Springs Harbor Symp Quant. Biol. 46: 985-996.Applicant
• Arnold et al., 1995, “Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96”, J. Exp. Med. 182:885-889.Applicant
• Cole & Ostrand-Rosenburg, 1991, “Rejection of allogeneic tumor is not determined by host responses to MHC class I molecules and is mediated by CD4−CD8+ T lymphocytes that are not lytic for the tumor”, Cellular Immunol. 134:480-490.Applicant
• Engman et al., 1990, “Human humoral immunity to hsp70 during Trypanosoma cruzi infection”, J. of Immunol. 144:3987-3991.Applicant
• Estes et al., 1993, “Characterization of an unusual cell type (CD4+CD3−) expanded by helminth infection and related to the parasite stress response”, J. of Immunol. 150:1846-1856.Applicant
• C. Ezzel, 1995, “Cancer ‘Vaccines’: An idea whose time has come?”, J. NIH Res. 7:46-49.Applicant
• Jindal & Young, 1992, “Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins”, J. of Virol. 66:5357-5362.Applicant
• Johnson et al., 1989, “The 86-kilodalton antigen from Schistosoma mansoni is a heat-shock protein homologous to yeast HSP-90”, Mol. and Biochem. Parasitol. 36:19-28.Applicant
• Luft et al., 1991, “Immunologic and structural characterization of the dominant 66- to 73-kDa antigens of Borrelia burgdoferi”, J. of Immunol. 146:2776-2782.Applicant
• Srivastava et al., 1994, “Heat shock proteins transfer peptides during antigen processing and CTL priming”, Immunogenetics 39:93-98.Applicant
• Udono & Srivastava, 1994, “Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70”, J. of Immunol. 152:5398-5403.Applicant
• Udono et al., 1994, “Cellular requirements for tumor-specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+ T cells in vivo”, PNAS USA 91:3077-3081.Applicant
• White et al., 1988, “Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells”, J. of Virol. 62:4153-4166.Applicant
• International Search Report, Related PCT Application No. PCT/US96/14557.Applicant
• Written Opinion dated Jul. 1, 1997, Related PCT Application No. PCT/US96/14557.Applicant
• Sadis and Hightower, 1992, “Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange”, Biochemistry 31:9406-9412.Applicant