US 5,452,407 AGrant
Method for Representing a Patient's Treatment Site as Data for Use With a CAD or CAM Device
Issue Date:1995-09-19
•40 Claims
•5 Drawing Sheets
Abstract
A method is described for representing a treatment site (10) of a patient as data suitable for use with a computer-aided design device (46). The method includes scanning the treatment site(10) with a scanning apparatus (40), such as a CT scanner, to produce image data; determining the image data that represents the surface of the item; generating vectors from the determined data; and associating the vectors with poles of a non-uniform rational B-spline so that a polynomial equation may be generated, which is a data form suitable for use with CAD devices.
Metadata
Assignee
- AMEI Technologies Inc.
Inventor
- David F. Crook
Application Information
Application Number:US 1587323
Filing Date:1993-11-29
Priority Date:1992-06-10
Art Unit:242
Classifications
IPC:
G06F 1542
Field of Search:
395364540121;124;128;129413.16;413.13;413.14;413.19;413.25;474.24730
Patent Drawings (5 sheets)
Description
This application is related to application Ser. No. 07/896,595, filed Jun. 10, 1992, now U.S. Pat. No. 5,356,996, and entitled "Method and Apparatus for Making Customized Fixation Devices", and is assigned to the same assignee.
1. TECHNICAL FIELD OF THE INVENTION
This invention relates in general to the field of signal processing and more particularly to a method for converting image data to vector data.
2. BACKGROUND OF THE INVENTION
Two computer-based graphic technologies have gained wide acceptance by practitioners in the respective field of each technology. The union of these technologies is awkward at best and unsatisfactory at worst.
The first computer-based graphic technology is known as computer aided tomography, computerized axial tomography, "CAT" or simply "CT." CT scans are sequential two-dimensional analysis of a given object's density. Typically the analyzed object is a portion of a human body. Each two-dimensional density analysis creates a mathematical model of the object's density. It may be used to determine the location and size of internal or otherwise hidden structures within a plane. These structures include bones and soft tissues. The sequence of density analysis may therefore be used to construct a three-dimensional representation of an internal structure on a video display using surface rendering methods such as shading and hidden-part removal. Each "slice"[of data is typically represented as an N.times.M array of data points.
The second computer-based graphic technology is known as a computer aided design or "CAD." CAD systems manipulate structures which are mathematically modeled. Typically the modeled structure is a machine part, or building. A programmer may easily manipulate the structure within the computer to, for instance, add or delete structure to the model. A programmer may also use the mathematical model to generate a solid object representative of the model using a computer-aided manufacturing, "CAM," system. A CAM system uses the mathematical model created by the programmer from a CAD system to control machining tools or other manufacturing equipment such as a stereolithographic apparatus ("SLA"). CAD data is efficiently stored as a set of mathematical equations. The equations generate the display each time the CAD model is used.
Heretofore, no method has existed for joining CT and CAD technologies in a manner which preserves the accuracy and precision of each technology separately.
Therefore, a need has arisen for a method for converting image data to vector data.
Summary of the Invention
In accordance with the present invention, a method for converting image data to vector data is provided which substantially eliminates or reduces disadvantages and problems associated with prior techniques.
A method is described for converting image data to vector data. The method comprises the steps of generating a vector to each of a set of points and associating each point with the pole of a control polygon of a non-uniform rational B-spline. The set of points are associated with a surface representative of a boundary of a three-dimensional object. Part of the boundary is hidden from view.
A first technical advantage of the disclosed invention is its union of CT imaging systems and CAD systems. A programmer now may automatically transfer the mathematical model of a scanned structure directly to a CAD system for manipulation. The transfer maintains the precision and accuracy of each separate technology.
A second technical advantage of the disclosed invention is its automatic nature. The data conversion may be automatically performed by a microprocessor without programmer intervention.
A third technical advantage of the disclosed invention is its use of preexisting equipment and procedures. The data conversion may be implemented on either a CT or CAD system with minor modifications. No other modification to existing CT and CAD procedures is necessary.
Brief Description of the Drawings
For a more complete understanding of the present invention and the advantages thereof, reference is now made to the following description taken in conjunction with the accompanying drawings, in which:
FIG. 1 depicts a traditional fixation device;
FIG. 2 depicts a customized fixation device made in accordance with the present invention;
FIG. 3 shows an apparatus made in accord with the present invention;
FIG. 4 is a block diagram describing one process sequence of the disclosed invention;
FIG. 5 depicts an isometric view of a human femur;
FIG. 6 is a graphical representation of a scanned volume partially coincident with the femur depicted in FIG. 5;
FIGS. 7a and 7b are graphical representations of the scanned volume of FIG. 6;
FIG. 8 is a further graphical representation of the scanned volume of FIG. 6;
FIG. 9 is a further graphical representation of the scanned volume of FIG. 6;
FIG. 10 is an isometric view of the CAD surface generated from FIG. 6; and
FIG. 11 is a block diagram describing one process sequence of the disclosed invention.
Detailed Description of the Invention
FIG. 1 depicts a treatment site 10 outfitted with a traditional fixation device 12. The traditional fixation device 12 comprises cross-bracing assembly 14, plates 16 and screws 18. Each of the items that comprises the traditional fixation device needs to be of a generalized nature as the surgeon does not have the ability to customize the device prior to surgery. As a result, the traditional fixation device 12 has a number of sharp edges and raised portions that can both be points of irritation as well as sources of infection. Each of screws 18 has a locking nut 20 to fasten the respective plate 16 to bone 22 of treatment site 10. Cross-bracing assembly 14 has clamps 24 that are held together using bolt 26 and nuts 28.
In contrast, FIG. 2 shows a treatment site 10 using a customized fixation device 30 made prior to surgery in accordance with the teachings of this invention. Because customized fixation device 30 can be manufactured prior to the surgery, it is designed specifically for the particular patient and is configured to conform as close as possible to the treatment site. As a result, the profile of device 30 is lower, all sharp edges are substantially reduced and the need for general types of assemblies such as plates and clamps are eliminated. Referring to FIG. 2, fixation device 30 comprises a single contoured brace 32 fastened to bone 22 using low profile screws 34. The edges of device 30 are rounded. Thus, potential sources of irritation and infection are reduced.
Referring now to FIG. 3, an apparatus for making a custom fixation device is shown. The apparatus comprises a scanning apparatus 40, an image combiner 42, a surgeon interface computer 44, a CAD system 46, a stereolithography system ("SLS") 48, a minifoundry 50 and finishing equipment 52.
It is contemplated by the present invention that a patient undergoing surgery will have a tomographic scan of the treatment site. Scanning apparatus 40 generates tomographic image data representative of a treatment site near in time and prior to the corrective procedure. The scanner will generate image data, as is more fully described below, that provides a series of two-dimensional images of the treatment site taken from various perspectives and orientations. The image data is then generally stored on disk or magnetic tape or other mass computer storage that can be provided to an image combiner 42.
Image combiner 42 or imaging system 42 takes the raw tomographic data and modifies it so that it will be suitable for use in the CAD system 46. Image combiner 42 is connected to surgeon interface computer 44.
Surgeon interface computer 44 permits the surgeon or other medical professional to review the tomographic image data and manipulate it in any fashion. Surgeon interface computer 44 is a conventional digital computer such as a lap-top personal computer that interacts with the conventional image combiner software as is known to those well skilled in the art. The modified image data, if modification is so desired, is then converted to CAD system data and loaded on to a conventional CAD system 46.
CAD system 46 is provided with the two-dimensional rendition of a three-dimensional treatment site suitable for the design of the customized fixation device. A technician or other suitably trained medical engineering professional using a library of components customizes a specific fixation device for use on the specified treatment site. Once the customized fixation device design is completed on CAD system 46, the CAD data is converted to slice data using a conventional digital computer suitably programmed, as is well known to those skilled in the art, to provide input to a stereolithography system 48.
Stereolithography system 48 takes the two-dimensional slice data and generates a three-dimensional object. The data contained in the CAD system 46 includes both data representing the treatment site as well as data showing the customized fixation device. Using stereolithography system 48, models of both the fixation device and the treatment site can be produced.
Once the treatment site and the fixation device have been rendered into three-dimensional objects using stereolithography system 48, the three-dimensional model of the treatment site can be provided to the surgeon for use in determining the appropriate surgical technique. The customized fixation device can also be provided to a minifoundry 50 for producing a metal part using the lost wax technique as is well known to those skilled in the art. The customized fixation device is made out of surgical steels, suitable for implantation as is conventionally known. Once the part is cast, it is provided to finishing equipment 52 for final preparation, such as cleaning, polishing and packaging, before sterilization and implantation by the surgeon.
SLS 48 may produce three-dimensional objects such as a custom prosthetic device and a drill guide. The former object is depicted in FIG. 2. The later object might appear as the former but the holes for screws 34 would be aligned such that a drill bit would bore a socket through the holes and into treatment site 10 along a preselected axis. In both cases, the device is fabricated with a contoured face that mates with treatment site 10.
Referring now to FIG. 4, a flow chart is depicted showing a method for making, for instance, a customized fixation device. The process begins at step 60 where tomographic image data is provided, typically on computer tape. First, the image data is converted in block 70 to CAD data. Block 70 is further described below in connection with FIG. 11. At a block 72, the CAD data is downloaded to a CAD workstation for design of the customized fixation device around the three-dimensional rendering of the patient treatment sight. At decision point 62, the process branches depending on whether the CAD data requires modification by the surgeon. If the answer is yes, the process follows path 64 where at a box 66, the CAD data is tuned to the surgical requirements of the surgeon. The surgeon may, for instance, isolate the area of interest for later processing steps. Then following path 67, the modified CAD data is returned to the CAD station. The loop going through box 66 will continue until such time as the surgeon is satisfied that the data conforms with his or her needs. At a block 74, the CAD image of either the customized fixation device or the treatment site, or both, are uploaded to a stereolithography system after the CAD data has been converted to slice data suitable for a stereolithography system.
At a block 74, the stereolithography system generates a model of either the fixation device or treatment site, or both. After a three-dimensional model has been rendered in block 74, a mold pouring facility, such as a minifoundry, is used to fabricate a solid metal device suitable for implantation at block 76. At a block 78, the metal fixation device is made ready for implantation and finished by removing all rough edges, burrs, machining marks, etc. A device with smooth rounded edges is thereby provided to the surgeon to minimize the possibility of irritation and infection in the patient. At a block 80, the customized fixation device may be assembled with a model of the treatment site for approval by the surgeon. The surgeon, if satisfied, implants the custom device into the patient at a block 82.
Medical tomographic imaging devices such as CT scanners, magnetic resonance imaging ("MRI") scanners and x-ray machines sample certain properties of tissue within a region of the human body. CT and MRI scanners sample the property within a two-dimensional plane. X-ray machines condense the property of several overlapping planes into a single two-dimensional plane. CT and MRI scanners then represent the sampled values as one or as a set of cross-sectional images.
The sampled property of a MRI scanner is the magnetic moment of a proton. The magnetic moment indicates the number of protons at the location and hence the overall mass density at the point. CT scanners and x-ray machines measure the macroscopic cross-section, .SIGMA., of a sample at the operating frequency of the CT scanner or x-ray machine. The macroscopic cross-section is proportional to the atomic density of the sample and, hence, may be used as a measure of the sample's local density.
Using either method, the measured density may be used to determine the boundaries between internal body structures if the accuracy and resolution of the measuring systems is sufficiently high. Present CT and MRI scanners are able to resolve volumes ("voxels," typically rectangular boxes each of whose six sides are rectangles) having dimensions 0.1.times.0.1.times.1.5 mm. This is sufficiently high to differentiate the delicate bony structures of the cranium and the intricate soft structures of the brain.
Other known tomographic methods such as positron emission ("PET") and ultrasound radiation techniques may be used to generate suitable data for the disclosed method.
CAD systems model some, if not all, shapes and structures as non-uniform rational B-splines ("NURBS"). NURBS have the advantage of allowing free-form as well as regular geometric shapes to be modeled and manipulated easily by a computer. NURBS do this by using multiple low order equations which require less computing power than would fewer higher order equations.
B-spline curves or surfaces are shapes comprising many polynomial segments pieced together. The order of the polynomials may be set by an operator to globally shape the curve. For instance, the segments may have order "one" which results in a series of straight segments. An order greater than one results in a series of curved segments. NURBS have the property that they are smooth at the junction between adjacent segments.
B-spline curves are defined by a set of poles, by a set of knots, and by a control polygon. A B-spline curve has a pole at each endpoint and a variable number spaced throughout the curve space. Each pole influences the shape of the curve by steering the curve toward them. The effect of each pole on the shape of the curve is determined by a set of blending functions associated with each pole. These blending functions make the curve smooth or straight. If a B-spline curve is non-uniform, the spacing between poles may vary from pole to pole. The control polygon is a polygon having each of its vertices coincident with one of the poles. It may be open like a zig-zag line or closed like a square. A knot is a point, usually operator selected, which defines where one polynomial segment ends and another begins. This allows discontinuities to exist in the generated surface.
FIG. 5 depicts an isometric view of a human femur 84. Although femur 84 is depicted devoid of surrounding tissue, it should be understood that femur 84 is, in the normal practice of the disclosed invention, hidden from view by surrounding tissue. In the illustration described herein, the importance of the shape of femur 84 is assumed. For instance, it may be necessary to replace the hip joint of femur 84 due to a pathological condition.
FIG. 6 is a graphical representation of a scanned volume partially coincident with the femur 84 depicted in FIG. 5. Femur 84 is scanned by a suitable imaging system such as a CT or MRI scanning system (not shown). The scanning system will determine the density of each voxel 86 in a region of interest indicated generally at 88. Although voxels 86 are depicted as cubes, other geometries including cylindrical, may be appropriate depending upon the selected scanning system. Also, voxels 86, though cubical as depicted, may have one or two dimensions substantially greater than the other. For instance, voxels 86 may have a thickness approximately ten times greater than their length or width. Such a variation is caused by the scanning nature of CT and MRI technologies. These scanners "slice" a subject into a series of parallel planes. The resolution of the scanners along the axis perpendicular to the series of planes may be less than the resolution within the planes.
FIGS. 7a and 7b are graphical representations of the scanned region of interest 88 of FIG. 6. After scanning, each voxel has a density associated with it. These densities may be filtered according to known methods to produce a binary density. Binary density is one in which each voxel density is either 0 or 1. Those voxels corresponding to a volume of space having a density greater than a preset threshold are assigned a density of one and are indicated by a dot. Those voxels having a density less than the threshold are assigned a density of zero and are indicated by a blank voxel. Only those voxels on the front three faces are depicted in FIG. 7a. FIG. 7b depicts the scanned volume split in half along a vertical plane. The right half of the volume has been rotated counterclockwise 90.degree. and has been translated to the right rear for illustrative purposes. An internal portion of each scanned slice is therefore visible. The outline of the femur 84 from FIG. 6 is also depicted as it is coincident with each voxel by a solid line.
The voxels 86 which correspond to femur 84 may be determined by other means. For instance, the voxels which correspond to femur 84 may be determined by a boundary based approach. A boundary based approach is one which examines density variation as a function of position to produce a density gradient at each voxel. Voxels having a gradient greater than a preset limit indicate that the voxel corresponds to the boundary of femur 84. Voxels within a structure may also be distinguished from those outside the structure by their common features or properties. For instance, if it was known a priori that the scanned structure comprised a first and second region having a corresponding first and second density, each voxel could be allocated to either group depending upon its particular density. These latter two methods and the binary filtering method each generate a set of voxels corresponding to femur 84.
FIG. 8 is a further graphical representation of the scanned volume of FIG. 6. Here, all voxels not corresponding to femur 84 have been removed. In addition, only the upper two most layers of voxels are depicted for clarity. The underlying bone mass is depicted isometrically by solid lines.
FIG. 9 is a graphical representation of a surface 90 generated by the scanned volume depicted in FIG. 8. After the voxels corresponding to the scanned structure have been identified, a surface is extracted corresponding to or defining the surface of the underlying scanned structure. The surface may be extracted according to the known method of Surface Tracking. Here, the surface corresponding to the first two layers of voxels is depicted. The surface corresponding to the plane which bisects femur 84 perpendicular to its length is omitted for clarity and because it is an arbitrary starting surface.
The surface is then mathematically described as a set of vectors to each surface of a boundary voxel. The particular transformation from CT slice location to vector depends upon the coordinate system of the underlying CT data. For instance, an MRI scan in rectangular coordinates (x, y, z) may be transformed to a vector in a rectangular coordinate system by scaling the triplet of numbers by three scaler quantities corresponding to an absolute or relative size. ACT scan in cylindrical coordinates may require a different transformation. All non-surface data from the original CT scan may then be discarded. The remaining data need not be stored in the original array format (an N.times.M array for each slice). The vectors may simply be stored as a table of triplets of numbers. This reduction allows substantial memory savings.
FIG. 10 is an isometric view of the CAD surface 92 generated from FIG. 6. According to the disclosed invention, each vector data point determined in connection with FIG. 6 is identified as a control point or pole of a NURB surface to a CAD system. A CAD system will then generate a series of low order polynomial equations which approximate the input data. The CAD processor will perform operations on these equations rather than on the input vector data points. The number of vectors or points may be further reduced by known geometric techniques. This increases processing speed and reduces memory requirements a second time.
FIG. 11 is a block diagram further describing block 70 of FIG. 4. CT data is generated in a block 94 as a series of sequential two-dimensional data arrays described above. The raw data is typically acquired using tomographic techniques. However, other methods may generate suitable data for the disclosed invention. The raw data is then filtered in a block 96 to distinguish between those data points corresponding to a particular structure of interest and those data points corresponding to other structures. The filtered data is then analyzed to produce a surface of the interested structure in a block 98. As described above, the method of surface tracking is used in the preferred embodiment. Other methods, however, may be used in place of this method. The surface is used to generate a set of vector data points corresponding to each voxel situated at a boundary of the structure of interest in a block 100. These data points are then fed to a CAD system with an instruction to treat each data point as a pole of a non-uniform rational B-spline in a block 102. The CAD system then generates a mathematical formula which approximates the surface points in a block 104.
The CT data may be generated by a suitable system such as a GE 9800 Scanner available from General Electric Corporation coupled to an imaging system such as one offered by Surgicad Corporation of Lebanon, N.H. The CAD data may be generated on a microcomputer or on a dedicated work station such as an Intergraph Engineering Modeling System from Intergraph Corp., of Huntsville, Ala. The remaining steps, blocks 96 through 102, may be performed by the Surgicad or Intergraph systems or by a suitable standalone microcomputer having a compatible data storage/retrieval system with both the imaging and CAD systems. The plastic implant model may be fabricated on a SLA250 manufactured by 3D Systems of Valencia, Calif.
Although the present invention and its advantages have been described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims
What is claimed is:
1. A method for representing a treatment site on a patient, the treatment site containing a surface, as data suitable for use with a computer-aided design device, the method comprising the steps of: scanning the treatment site with a scanning apparatus to produce image data for a plurality of voxels; identifying a plurality of boundary voxels representative of the surface of the treatment site; generating a vector representing the location of each boundary voxel; and converting the vectors into a form of data suitable for use with a computer-aided design device by associating each of the vectors with a pole of a control polygon of a non-uniform rational B-spline.
2. The method of claim 1 wherein the step of converting the vectors into a form of data suitable for use with a computer-aided design device further comprises the step of generating a polynomial equation from the non-uniform rational B-spline.
3. The method of claim 1 wherein said step of scanning the treatment site with a scanning apparatus to produce image data comprises scanning the treatment site with a CT scanner.
4. The method of claim 1 wherein said step of scanning the treatment site With a scanning apparatus to produce image data comprises scanning the treatment site with a MRI scanner.
5. A method for modelling an image of a surface of a treatment site on a patient, the method comprising the steps of: generating a plurality of sets of data values for a plurality of voxels defining a three dimensional object, the data values within each set corresponding to a property of a three-dimensional object along the first and a second dimension, the object defining the treatment site, each set of data values corresponding to the property at one of a plurality of predetermined positions along a third dimension; identifying the voxels that define the surface; measuring a magnitude of each identified voxel; using the magnitude of each identified voxel to generate a corresponding vector; converting the vectors into computer-aided-design data suitable for use with a computer-aided design device by associating each vector with a pole of a control polygon of a non-uniform rational B-spline; converting the computer-aided-design data into slice data suitable for use with a stereolithography system; and forming a model of the image with the stereolithography system.
6. The method of claim 5 wherein the step of identifying comprises the steps of: converting the data value into binary data values; and surface tracking the binary data values to identify the data values that define the surface.
7. The method of claim 5 wherein the step of generating the plurality of sets of data values comprises the step of: generating the plurality of sets Of data values tomographically.
8. The method of claim 7 wherein the step of generating the plurality of sets of data values tomographically comprises the step of: scanning the treatment site with a CT scanner.
9. The method of claim 7 wherein the step of generating the plurality of sets of data values tomographically comprises the step of: scanning the treatment site with an MRI scanner.
10. The method of claim 5 wherein the step of converting the plurality of vectors into the computer-aided-design data comprises the step of: generating a polynomial equation from the non-uniform rational B-spline.
11. The method of claim 5 wherein the step of forming comprises the step of: forming a model of the inverse image of the surface of the treatment site.
12. The method of claim 5 wherein the step of forming comprises the step of: forming a model of direct image of the surface of the treatment site.
13. The method of claim 5 further comprising the step of: generating a replica of the treatment site.
14. The method of claim 5 further comprising the step of: generating a fixation device having a treatment-site mating surface with a contour substantially conforming to the inverse image of the surface of the treatment site.
15. A method for producing a visual representation of at least a portion of an image of an object comprising the steps of: generating an image of an object including a structure of interest using a non-intrusive image generating device which produces a set of image data; filtering the image data to distinguish between image data points corresponding to a structure of interest and image data points corresponding to other structures; generating a surface representation of the structure of interest using the filtered image data; generating a set of vectors from the surface representation defining the boundary of the structure of interest; associating each vector with a pole of a non-uniform rational B-spline to create a series of such B-splines; generating one or more polynomial equations from one or more nonuniform rational B-splines; and displaying a visual representation of the structure of interest utilizing a display device which displays images utilizing polynomials generated from non-uniform rational B-splines.
16. The method of claim 15, wherein the step of generating an image of an object is performed by a CT scanner.
17. The method of claim 15, wherein the step of generating an image of an object is performed by a MRI scanner.
18. The method of claim 15, wherein the step of generating an image of an object is performed by an X-ray scanner.
19. The method of claim 15, wherein the step of generating an image of an object is performed by a PET scanner.
20. The method of claim 15, wherein the step of generating a surface representation of the structure of interest is performed using surface tracking.
21. The method of claim 15, wherein the step of filtering the image data is performed according to a binary density filtering method.
22. The method of claim 21, wherein the step of generating a surface representation of the structure of interest is performed using surface tracking.
23. The method of claim 15, wherein the step of filtering the image data is performed according to a boundary-based approach based on the density gradient of the set of image data points.
24. The method of claim 23, wherein the step of generating a surface representation of the structure of interest is performed using surface tracking.
25. The method of claim 15, wherein the step of displaying a visual representation of the structure of interest is performed by a CAD system.
26. The method of claim 15, wherein: the step of generating an image of an object is performed by a CT scanner; the step of generating a surface representation of the structure of interest is performed using surface tracking; and the step of filtering the image data is performed according to a binary density filtering method.
27. The method of claim 26, wherein the step of displaying a visual representation of the structure of interest is performed by a CAD system.
28. The method of claim 15, wherein: the step of generating an image of an object is performed by a CT scanner; the step of generating a surface representation of the structure of interest is performed using surface tracking; and the step of filtering the image data is performed according to a boundary-based approach based on the density gradient of the set of image data points.
29. The method of claim 28, wherein the step of displaying a visual representation of the structure of interest is performed by a CAD system.
30. The method of claim 15, wherein: the step of generating an image of an object is performed by a MRI scanner; the step of generating a surface representation of the structure of interest is performed using surface tracking; and the step of filtering the image data is performed according to a binary density filtering method.
31. The method of claim 30, wherein the step of displaying a visual representation of the structure of interest is performed by a CAD system.
32. The method of claim 15, wherein: the step of generating an image of an object is performed by a MRI scanner; the step of generating a surface representation of the structure of interest is performed using surface tracking; and the step of filtering the image data is performed according to a boundary-based approach based on the density gradient of the set of image data points.
33. The method of claim 32, wherein the step of displaying a visual representation of the structure of interest is performed by a CAD system.
34. A method for physically modelling an image of a surface of a structure of interest, the method comprising the steps of: generating an image of an object including the structure of interest using a non-intrusive image generating device which produces a set of image data; filtering the image data to distinguish between image data points corresponding to the structure of interest and image data points corresponding to other structures; generating a surface representation of the structure of interest using the filtered image data; generating a set of vectors from the surface representation defining the boundary of the structure of interest; associating each vector with a pole of a non-uniform rational B-spline to create a series of such B-splines; generating one or more polynomial equations from one or more nonuniform rational B-splines; converting the polynomial equations into slice data suitable for use with a stereolithography system; and forming a model of the image of the surface of the structure of interest with the stereolithography system.
35. The method of claim 34 wherein the step of forming comprises the step of: forming a model of the inverse image of the surface.
36. The method of claim 35 further comprising the step of: using the model of the inverse image as a mold to form a model of a direct image of the surface.
37. The method of claim 34 wherein the step of forming comprises the step of: forming a model of a direct image of the surface.
38. The method of claim 37 further comprising the step of: using the model of the direct image as a mold to form a model of the inverse image of the surface.
39. The method of claim 34 further comprising the step of: generating a replica of the structure of interest.
40. The method of claim 34 further comprising the step of: generating a device having a mating surface for closely mating with the surface of the structure of interest, the mating surface having a contour substantially conforming to the inverse image of the surface.
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