US 4,278,570 AGrant
Cosmetic Cleanser Formulation
Issue Date:1981-07-14
•1 Claims
Abstract
A skin cleanser formulation, which is one of four components used in a cosmetic regime, is disclosed. Applying the regime to the skin increases epidermal cell turnover without skin irritation. The other three components used in the regime are a cream, a lotion, and a tonic.
Metadata
Assignee
- Eli Lilly and Company
Inventor
- Merlyn G. Flom
Application Information
Application Number:US 1796283
Filing Date:1980-08-20
Priority Date:1980-08-20
Art Unit:166
Classifications
IPC:
C11D 184A61K 748
Field of Search:
252424155;174.22;542;546170;172;365
Patent Drawings
This patent does not have any drawings.
Description
BACKGROUND OF THE INVENTION
This invention relates to one component for use in a novel cell renewal cosmetic regime, which regime increases the rate of cell turnover without skin irritation.
In the natural renewing cycle of skin, cells are constantly being born, rising through the epidermal layers to the surface and falling off. A young skin renews its surface layers every two to three weeks. A mature skin can take twice as long. And the longer this process takes, the more cells develop areas of weakness that cause a faster loss of natural moisture and the dry lifeless appearance that's found in older looking skin.
Acceleration of natural cell renewal or turnover speeds the replacement of dead cells by new ones in the outer epidermal layer or stratum corneum, thereby giving the skin a younger-looking appearance. The newer cells are moist and fresh, replacing the old, dry cells on the surface.
Although irritation of the skin will increase the sloughing off of dead stratum corneum cells, such irritation is undesirable because of the damage to the skin. It is, therefore, desirable to increase cell turnover without irritation.
SUMMARY OF THE INVENTION
It is, therefore, an object of the present invention to provide a skin cleanser formulation, which is one of four components for use in a cosmetic regime. The regime's use increases epidermal cell turnover without skin irritation. The other three components for use in the regime are: a cream, a lotion, and a tonic.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In accordance with this invention there is provided a skin cleanser formulation, which is one of four components for use in a cosmetic regime. The use of the regime increases cell turnover without causing skin irritation. The regime consists of the application to the skin of a cleanser, a cream, a lotion, and a tonic. Each of the three other components is a separate invention; the cream is claimed in application Ser. No. 179,626, filed of even date herewith, the lotion is claimed in application Ser. No. 179,629, also filed of even date herewith; and the tonic is claimed in application Ser. No. 179,624, filed of even date herewith. The use of the four components in a regime to increase cell turnover without causing skin irritation is claimed in application Ser. No. 179,627, filed of even date herewith.
The preferred regime usually begins in the morning with the use of the tonic, followed by the lotion. Later, usually at night, the cleanser is used, and then the tonic and cream are applied. However, the order and the timing of the use of the four products can be varied to suit individual needs. For example, the cleanser also can be used in the morning. Some effect will be obtained even if all the compositions are not used or if there is a delay between usage.
The cleanser formulation consists essentially of, in percent by weight:
In general, the individual ingredients used in the formulation should be of quality or purity (such as U.S.P. or N.F.) suitable for cosmetic use.
The formulation of this invention is prepared by mixing the ingredients according to conventional methods. The preparation of this formulation is described in the following example. The example is illustrative of the formulation embraced by the invention, but is not to be construed as limiting the invention.
EXAMPLE 1
Cleanser
Formulation:
Procedure:
Phase A is prepared one day before the rest of the batch by adding the titanium dioxide to the Deriphat 160C with constant mixing by a Lightnin' mixer. Mixing is continued until a uniform mass is obtained and the titanium dioxide is completely wetted. Phase A is aged overnight at room temperature.
A dry blend of the Phase B ingredients is prepared separately from Phase A the next day. Phase B is then slowly added to Phase C, while mixing vigorously with a Lightnin' mixer. Phase BC is mixed continuously and then added to Phase D. Phase BCD is mixed with a sweep agitator until all the gum is dispersed.
The ingredients of Phase E are added one at a time to Phase BCD and mixed until all the powders are dissolved. Phase A is remixed thoroughly with a Lightnin' mixer until uniform. Phase A is added to Phase BCDE, while mixing with sweep and side agitation for about 5 to 10 minutes. Afterwards Phase ABCDE is heated to about 80.degree.-85.degree. C. with continued mixing.
Phase F is prepared in a separate container and heated to about 90.degree.-95.degree. C. Mixing and heating are continued until the soya sterols are melted and the mixture is uniform. Phase F is then added to Phase ABCDE and mixed thoroughly.
Phase ABCDEF is then cooled to 60.degree.-65.degree. C. with continuous mixing, and then Phase G is added. Everything is then mixed thoroughly with the side-sweep. Phase ABCDEFG is cooled to about 45.degree.-50.degree. C., and then Phase H is added. The side-sweep is used to mix the phases, while the entire mixture is allowed to cool to room temperature. Mixing is continued with the side-sweep for about 15-20 minutes and the mixture is transferred into suitable stainless steel containers.
When the above-described formulations are used in accordance with the method of this invention, the rate of skin cell turnover is increased without skin irritation. The rate of skin cell turnover is frequently reported as transit time. Transit time is defined as the time required for a newly formed stratum corneum cell to rise up through the stratum corneum and finally slough off. Therefore, the less transit time required, the better the appearance of the skin, because younger cells are on its surface.
The test for measuring transit time is described by L. H. Jansen, et al., "Improved Fluorescence Staining Technique for Estimating Turnover of the Human Stratum Corneum," British Journal of Dermatology, 1974, 90, 9-12. The transit or replacement time of the human stratum corneum is determined by measuring the number of days required for a fluorescent marker, dansyl chloride, to disappear after application to the skin. The dansyl chloride only stains the stratum corneum (outer cell layer) and the shedding of the stratum corneum is signified by the disappearance of the dansyl chloride.
Using the Jansen procedure, the transit time of the present regime is measured and compared with the transit time of several commercially available, skin-care cosmetic products, identified as products A to E in Table I. Dansyl chloride is applied to both upper inner arms of each subject, after two weeks of pretreatment with the product. Then one arm is treated daily with the particular product, while the other arm is untreated. The number of days required for the dansyl chloride to disappear from each arm is then recorded. The results for the treated arms are averaged for the particular product and compared to the average for the untreated arms. The results are shown in Table I. The larger the difference between the control and treated times, the more effective is the product.
The test was run using women from young (19-29 years) and middle (31-58 years) age groups for products A-E and the regime.
The present regime consists of using all four components in the following order: the cleanser and tonic were used in the morning, followed by the lotion; later, at night, the cleanser was used and then the tonic and cream were applied.
Claims
I claim:
1. A skin cleanser formulation consisting essentially of, in percent by weight: Ingredients Percent ______________________________________ deionized water 39.73 propylene glycol 6.00 magnesium aluminum silicate 1.10 sodium carboxymethyl cellulose 0.10 methyl p-hydroxybenzoate 0.20 imidazolidinyl urea 0.30 ethylenediaminetetraacetic acid 0.02 sodium N-lauryl-.beta.-iminodipropionate 4.00 titanium dioxide 0.75 sodium isostearoyl-2-lactylate 2.00 soya sterols 1.00 polyoxyethylene (10) soya sterols 2.50 polyoxyethylene (3) myristyl ether myristate 8.00 polyoxypropylene (15) stearyl ether 8.00 heavy mineral oil 8.00 propylene glycol dicaprylate/dicaprate (80/20 to 50/50) 7.00 cetyl alcohol (1-hexadecanol) 4.00 stearyl alcohol (1-octadecanol) 2.00 propyl p-hydroxybenzoate 0.10 glyceryl monostearate and polyethylene glycol (100) monostearate 2.00 triple pressed stearic acid 2.50 lactic acid 0.10 fragrance 0.60 ______________________________________
Patent Citations (3)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US3186912 | 1965-06-01 | Beamer | |
| US3919430 | 1975-11-01 | Siegel | |
| US4216201 | 1980-08-01 | Calvo |
Non-Patent Literature (4)
- Balsam, M. S. et al., Cosmetics-Science and Technology; 2nd Ed., Wiley-Inter-Science, Copyright 1972, pp. 18, 19.
- Bennett, H., The Chemical Formulary; vol. XV, 1970, Chemical Publishing Co., N.Y., pp. 94 & 95.
- Bennett, H., The Chemical Formulary, vol. XIX, 1976, Chemical Publishing Co., N.Y., pp. 164, 165.
- Henkel Inc., "Facial Washing Cream and Make-Up Remover", Product Bulletin (Cosmetic Formulary).