US 4,239,763 AGrant
.Alpha.-Blocking Agents in the Treatment of Obesity
Issue Date:1980-12-16
•4 Claims
Abstract
Alpha-blocking agents, especially 9,10-dihydroergot-peptide alkaloids, are anti-obesity agents.
Metadata
Assignee
- Sandoz Ltd.
Inventors
- Maria Milavec
- Heribert Wagner
Application Information
Application Number:US 0510556
Filing Date:1979-06-22
Priority Date:1977-10-24
Art Unit:125
Classifications
IPC:
A61K 3148
Field of Search:
424261
Patent Drawings
This patent does not have any drawings.
Description
By way of example the following compositions may be used in the method of the invention.
EXAMPLE 1
Dihydroergotamine tablets
Each tablet contains:
Dihydroergotamine mesylate: 1.015 mg
Tartaric acid: 0.1 mg
Lactose (pulverized): 84.985 mg
Corn starch: 8.00 mg
Gelatine: 0.3 mg
Magnesium stearate: 0.5 mg
Stearic acid: 1.1 mg
Talc: 4 mg
EXAMPLE 2
Dihydroergotoxin tablets
Each tablet contains:
Dihydroergotoxin mesylate: 1.015 mg
Stearic acid: 2 mg
Polyvinylpyrrolidone: 4 mg
Talc: 4 mg
Corn starch: 8 mg
Lactose: 140.985 mg
If desired tablets may be made with 0.25 mg or 15 mg of dihydroergotoxin mesylate in analogous manner.
The above-mentioned tablets are useful in the treatment of obesity when administered 3 to 5 times a day.
Claims
What we claim is:
1. A method of treating obesity or reducing body weight in animals in need of such treatment which comprises administering to said animals a therapeutically effective amount of a 9,10-dihydro-ergot-peptide of the formula ##STR2## wherein R.sub.1 is isopropyl, isobutyl, sec. butyl or benzyl, R.sub.2 is methyl, ethyl or isopropyl and R.sub.3 is methyl or isopropyl.
2. A method of claim 1 wherein the compound is dihydroergotamine or dihydroergotoxine.
3. A method of claim 1 wherein the compound is administered in unit dosage form containing from about 0.02 mg to about 15 mg.
4. A method of claim 1 wherein the compound is administered in conjunction with a low calorie or slimming diet.