US 4,024,167 AGrant
11-Dioxy-Cis-4,5-Didehydro-PGF Compounds
Issue Date:1977-05-17
•4 Claims
Abstract
This invention relates to a group of cis-4,5-didehydro-11-deoxy-PG.sub.1 analogs having variable chain length, optional methyl substitution in the methyl-terminated side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including ulcer treatment, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.
Metadata
Assignee
- The Upjohn Company
Inventors
- Gordon L. Bundy
- Norman A. Nelson
Application Information
Application Number:US 648266&
Filing Date:1976-01-12
Priority Date:1975-02-10
Art Unit:127
Classifications
IPC:
C07C17700
Field of Search:
260410.9 R;413;468 D;514 D
Patent Drawings
This patent does not have any drawings.
Description
The present invention relates to prostaglandin analogs, for which the essential material constituting a disclosure thereof is incorporated by reference here from U.S. Pat. No. 3,987,072, issued Oct. 19, 1976.
Claims
We claim:
1. A compound of the formula ##STR1## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
2. A compound of the formula ##STR2## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
3. A compound of the formula ##STR3## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
4. cis-4,5-Didehydro-11-deoxy-16,16-dimethyl-PGF.sub.1.alpha., 15-methyl ether, methyl ester, a compound according to claim 3.
Patent Citations (2)
| Patent | Date | Inventor | Cited By |
|---|---|---|---|
| US3917668 | 1975-11-01 | Abraham et al. | |
| US3932479 | 1976-01-01 | Bernady et al. |