Antiviral agent for drug-resistant virus

[0001] The present invention relates to a method for treating a YMDD mutant virus disease which shows a drug-resistance against lamivudine (()--L-2,3-dideoxy-3-thiacytidine, which is referred to as 3TC) which is a conventional antiviral agent. More specifically, the present invention relates to a method for treating a virus disease which comprises administering a phosphonate nucleotide compound having the above-mentioned antiviral activity, or a salt thereof, or a hydrate thereof or a solvate thereof.

[0002] Among virus diseases, especially human immunodeficiency virus (HIV) infection (i.e., acquired immune deficiency syndrome (AIDS)) and hepatitis B virus (HBV) infection (i.e., hepatitis B) are considered to be a medically crucial problem because of the high absolute number of patients presented in the world. For the purpose of treating these diseases, various agents having an antiviral activity has been actively developed. Among such agents, lamivudine was developed as the first antiviral agent which inhibits the replication of both HIV and HBV, and it has already been approved as an agent for HIV infection in large number of countries. Lamivudine has recently been approved also for HBV infection in some countries, and there are many reports that lamivudine has clinically been used. The greatest problem regarding the treatment of HBV infection with lamivudine discussed in these reports is that an emergence of drug-resistant viruses increases after the long term administration of lamivudine. It is known that these drug-resistant viruses, as is in the case of HIV, have the mutation of methionine residue in an amino acid sequence, tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif located in an active center of a viral DNA polymerase. In the case of HIV, there has been reported a result of the X-ray crystallographic analysis of a YMDD mutant polymerase (Sarafianos, S. G. et al., Proc. Natl. Acad. Sci., USA 96, 10027-10032 (1999)). This result suggests a possibility that the substitution of methionine by isoleucine or valine interferes the binding of lamivudine triphosphate to an active center and a possibility of cross-resistance to other nucleoside derivatives having -L-ring occurs. On the other hand, in the case of HBV, the single substitution of leucine by methionine (L528M) on the B domain of HBV polymerase identified by the clinical trial of Famciclovir (2-2-(2-amino-9H-purin-9-yl)ethyl-1,3-propanediol diacetate) against HBV infection shows a resistance to Famciclovir (Seigneres, B., et al., J. Infect. Dis., 181, 1221-1233 (2000)). It is suggested, however, that since a YMDD mutant HBV also having a L528M mutation acquires a higher ability to replicate viral DNA than HBV having a single YMDD mutation, and emerges as a cross drug-resistant HBV (Ono, S. K., et al., J. Clin. Invest., 107, 449-455 (2001)). Summarizing several reports, the emergence rate of a YMDD mutant virus in hepatitis B patients is 17 to 46% after the continuous use of lamivudine for 1 year, and 65 to 75% after the use of lamivudine for 3 to 4 years (Ono, S. K., et al., J. Clin. Invest., 107, 449-455 (2001)). The emergence of a drug-resistant mutant virus reduces the efficacy of the agent. As a result, even if the administration of the agent is continued, proliferation of the virus occurs, resulting in the recurrence of hepatitis B. If the administration of the agent is stopped at this moment, a wild type of HBV having a higher replication ability than drug-resistant mutant virus proliferates again, resulting in the fear of the occurrence of fulminate hepatitis in some cases. However, since it is only lamivudine that has been approved as an antiviral agent against HBV, there is a therapeutic contradiction in that the patients is administered with lamivudine, even if lamivudine is ineffective, and this contradiction would cause some hesitation in administrating the agent to a new hepatitis B patient.

[0003] The present inventors have already found that some of phosphonate nucloetide compounds show a high oral absorbency (EP632048), and have obtained an antiviral agent having anti-HBV activity without toxicity such as bone marrow cell growth inhibition or mutagenicity by changing the base portion of those compounds to a specific structure (EP785208). These compounds having a several ten-fold activity as compared with lamivudine, have been developed as novel agents for treating hepatitis B.

[0004] The present invention is based on a new finding that the phosphonate nucleotides having a specific structure are effective even against a YMDD mutant HBV and can be a potent tool to overcome the above-stated contradiction regarding the treatment with lamivudine.

[0005] The object of the present invention is to provide a method for treating a drug resistant virus disease by using an antiviral agent effective for the wild type viruses as well as for YMDD mutant viruses which are resistant to antiviral agents such as lamivudine.

[0006] Through intensive studies directed toward the above object, the present inventors have found that certain 2-amino-6-arylthiopurinephosphonates, which are not concretely disclosed in the above EP632048, have a high antiviral activity, and that these compound have an inhibitory activity against the proliferation of a YMDD mutant virus, thereby completing the present invention.

[0007] Thus, the present invention greatly improves the lamivudine-based method for treating hepatitis B, by using a phosphonate nucleotide compound represented by the following formula (I):

[0008] wherein

[0009] R¹ is a hydrogen atom, a hydroxyl group, a C₁-C₆ alkoxy group, a C₁-C₄ alkoxy group substituted by one or more halogen atoms, a halogen atom, an amino group or a nitro group;

[0010] each of R² and R³ is independently a hydrogen atom, a C₁-C₂₂ alkyl group, an acyloxymethyl group, an acylthioethyl group or an ethyl group substituted by one or more halogen atoms;

[0011] R⁴ is a hydrogen atom, a C₁-C₄ alkyl group, a C₁-C₄ hydroxyalkyl group or a C₁-C₄ alkyl group substituted by one ore more halogen atoms; and

[0012] X is CH or a nitrogen atom,

[0013] or a salt thereof, or a hydrate thereof or a solvate thereof.

[0014] The compounds used in the present invention are described in detail below.

[0015] In respect of the phosphonate nucleotide compound of the above formula (I), examples of a C₁-C₆ alkoxy group represented by R¹ include a methoxy group, an ethoxy group, an n-propoxy group, an isopropoxy group, an n-butoxy group, an isobutoxy group, a sec-butoxy group, a tert-butoxy group, an n-pentyloxy group, an n-hexyloxy group and the like. Examples of a C₁-C₄ alkoxy group substituted by one or more halogen atoms represented by R¹ include a monofluoromethoxy group, a difluoromethoxy group, a trifluoromethoxy group, a monofluoroethoxy group, a difluoroethoxy group, a trifluoroethoxy group, a tetrafluoroethoxy group, a pentafluoroethoxy group, a monofluoropropoxy group, a difluoropropoxy group, a trifluoropropoxy group, a tetrafluoropropoxy group, a pentafluoropropoxy group, a hexafluoropropoxy group, a heptafluoropropoxy group, a monofluoroisopropoxy group, a difluoroisopropoxy group, a trifluoroisopropoxy group, a tetrafluoroisopropoxy group, a pentafluoroisopropoxy group, a hexafluoroisopropoxy group, a heptafluoroisopropoxy group and the like.

[0016] Examples of a C₁-C₂₂ alkyl group represented by R²and R³ include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a pentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group, a decyl group, an undecyl group, a dodecyl group, a tridecyl group, a tetradecyl group, a pentadecyl group, a hexadecyl group, a heptadecyl group, an octadecyl group, a nonadecyl group, an icosyl group, a henicosyl group, a docosyl group and the like.

[0017] Examples of an acyloxymethyl group represented by R² and R³ include an acetyloxymethyl group, a propionyloxymethyl group, a butyryloxymethyl group, an isobutyryloxymethyl group, a valeryloxymethyl group, an isovaleryloxymethyl group, a pivaloyloxymethyl group and the like.

[0018] Examples of an acylthioethyl group represented by R² and R³ include an acetylthioethyl group, a propionylthioethyl group, a butyrylthioethyl group, an isobutyrylthioethyl group, a valerylthioethyl group, an isovalerylthioethyl group, a pivaloylthioethyl group and the like.

[0019] In an ethyl group substituted by one or more halogen atoms represented by R² and R³, the type of the halogen atom may be any of a fluorine, chlorine, bromine or iodine atom. Examples of an ethyl group substituted by one or more halogen atoms include a 1-fluoroethyl group, a 2-fluoroethyl group, a 1-chloroethyl group, a 2-chloroethyl group, a 2-bromoethyl group, a 2,2-difluoroethyl group, a 2,2-dichloroethyl group, a 2,2-dibromoethyl group, a 2,2,2-trifluoroethyl group, a 2,2,2-trichloroethyl group, a 2,2,2-tribromoethyl group and the like. It is particularly preferable that the 2-position of an ethyl group is substituted, and the preferred halogen atom is a fluorine atom. At least one of R² and R³ is preferably an ethyl group substituted by one or more halogen atoms, and is particularly preferably a 2,2,2-trifluoroethyl group.

[0020] Examples of a C₁-C₄ alkyl group represented by R⁴ include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group and the like. Examples of a C₁-C₄ hydroxyalkyl group represented by R⁴ include a hydroxymethyl group, a 1-hydroxyethyl group, a 2-hydroxyethyl group, a 1-hydroxypropyl group, a 2-hydroxypropyl group, a 3-hydroxypropyl group, a 1-hydroxybutyl group, a 2-hydroxybutyl group, a 3-hydroxybutyl group, a 4-hydroxybutyl group and the like. Examples of a C₁-C₄ alkyl group substituted by one or more halogen atoms represented by R⁴ include a group in which a halogen atom(s) such as a fluorine atom or a chlorine atom is bound to a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group and the like. Specific examples of such a group include a fluoromethyl group, a difluoromethyl group, a trifluoromethyl group, a fluoroethyl group, a chloroethyl group, a fluoropropyl group, a chloropropyl group, a fluorobutyl group, a chlorobutyl group and the like.

[0021] The first condition for the preferred compounds used in the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₆ alkoxy group. The second condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₆ alkoxy group, and each of R² and R³ is independently a hydrogen atom, a C₁-C₂₂ alkyl group or an ethyl group substituted by one or more halogen atoms. Moreover, the third condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₆ alkoxy group, each of R²and R³ is independently a hydrogen atom, a C₁-C₂₂ alkyl group or a 2,2,2-trifluoroethyl group, and R⁴ is a hydrogen atom or a methyl group. Furthermore, the fourth condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₆ alkoxy group, each of R² and R³ is independently a hydrogen atom or a 2,2,2-trifluoroethyl group, and R⁴ is a hydrogen atom or a methyl group.

[0022] Specific examples of preferred compounds which satisfy this condition include:

[0023] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-phenylthiopurine;

[0024] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-methoxyphenylthiopurine;

[0025] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-methoxyphenylthiopurine;

[0026] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-methoxyphenylthiopurine;

[0027] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-ethoxyphenylthiopurine;

[0028] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-phenylthiopurine;

[0029] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-methoxyphenylthiopurine;

[0030] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-phenylthiopurine;

[0031] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-methoxyphenylthiopurine;

[0032] 2-amino-9-2-(phosphonomethoxy)ethyl-6-phenylthiopurine;

[0033] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-methoxyphenylthiopurine;

[0034] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-butoxyphenylthiopurine;

[0035] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-propoxyphenylthiopurine;

[0036] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isopropoxyphenylthiopurine;

[0037] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isobutoxyphenylthiopurine;

[0038] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-hydroxyphenylthiopurine;

[0039] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-hydroxyphenylthiopurine;

[0040] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-hydroxyphenylthiopurine;

[0041] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-hydroxyphenylthiopurine;

[0042] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-hydroxyphenylthiopurine; and

[0043] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-hydroxyphenylthiopurine.

[0044] Furthermore, specific examples of preferred compounds which satisfy the fourth condition include:

[0045] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-ethoxyphenylthiopurine;

[0046] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-ethoxyphenylthiopurine;

[0047] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-butoxyphenylthiopurine;

[0048] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-propoxyphenylthiopurine;

[0049] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isopropoxyphenylthiopurine;

[0050] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isobutoxyphenylthiopurine;

[0051] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-butoxyphenylthiopurine;

[0052] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-propoxyphenylthiopurine;

[0053] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isopropoxyphenylthiopurine;

[0054] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonybmethoxyethyl-6-o-isobutoxyphenylthiopurine;

[0055] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-methoxyphenylthiopurine;

[0056] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-methoxyphenylthiopurine;

[0057] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-ethoxyphenylthiopurine;

[0058] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-ethoxyphenylthiopurine;

[0059] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-ethoxyphenylthiopurine;

[0060] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-butoxyphenylthiopurine;

[0061] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-propoxyphenylthiopurine;

[0062] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isopropoxyphenylthiopurine;

[0063] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isobutoxyphenylthiopurine;

[0064] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-butoxyphenylthiopurine;

[0065] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-propoxyphenylthiopurine;

[0066] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isopropoxyphenylthiopurine;

[0067] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isobutoxyphenylthiopurine;

[0068] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-butoxyphenylthiopurine;

[0069] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-propoxyphenylthiopurine;

[0070] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isopropoxyphenylthiopurine;

[0071] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isobutoxyphenylthiopurine;

[0072] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-methoxyphenylthiopurine;

[0073] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-methoxyphenylthiopurine;

[0074] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-ethoxyphenylthiopurine;

[0075] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-ethoxyphenylthiopurine;

[0076] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-ethoxyphenylthiopurine;

[0077] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-butoxyphenylthiopurine;

[0078] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-propoxyphenylthiopurine;

[0079] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isopropoxyphenylthiopurine;

[0080] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isobutoxyphenylthiopurine;

[0081] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-butoxyphenylthiopurine;

[0082] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-propoxyphenylthiopurine;

[0083] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isopropoxyphenylthiopurine;

[0084] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isobutoxyphenylthiopurine;

[0085] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-butoxyphenylthiopurine;

[0086] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonybmethoxyethyl-6-o-propoxyphenylthiopurine;

[0087] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isopropoxyphenylthiopurine;

[0088] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isobutoxyphenylthiopurine;

[0089] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-phenylthiopurine;

[0090] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-methoxyphenylthiopurine;

[0091] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-methoxyphenylthiopurine;

[0092] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-methoxyphenylthiopurine;

[0093] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-ethoxyphenylthiopurine;

[0094] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-ethoxyphenylthiopurine;

[0095] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-ethoxyphenylthiopurine;

[0096] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-butoxyphenylthiopurine;

[0097] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-propoxyphenylthiopurine;

[0098] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isopropoxyphenylthiopurine;

[0099] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isobutoxyphenylthiopurine;

[0100] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-butoxyphenylthiopurine;

[0101] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-propoxyphenylthiopurine;

[0102] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isopropoxyphenylthiopurine;

[0103] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isobutoxyphenylthiopurine;

[0104] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-butoxyphenylthiopurine;

[0105] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-propoxyphenylthiopurine;

[0106] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isopropoxyphenylthiopurine;

[0107] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isobutoxyphenylthiopurine;

[0108] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-hydroxyphenylthiopurine;

[0109] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-hydroxyphenylthiopurine;

[0110] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonybmethoxyethyl-6-o-hydroxyphenylthiopurine;

[0111] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-hydroxyphenylthiopurine;

[0112] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-hydroxyphenylthiopurine;

[0113] 2-amino-9-2-(2,2,2-trifluoroethyl)phosphonybmethoxypropyl-6-o-hydroxyphenylthiopurine;

[0114] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-methoxyphenylthiopurine;

[0115] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-methoxyphenylthiopurine;

[0116] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-ethoxyphenylthiopurine;

[0117] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-ethoxyphenylthiopurine;

[0118] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-ethoxyphenylthiopurine;

[0119] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-butoxyphenylthiopurine;

[0120] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-propoxyphenylthiopurine;

[0121] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-isopropoxyphenylthiopurine;

[0122] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-isobutoxyphenylthiopurine;

[0123] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-butoxyphenylthiopurine;

[0124] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-propoxyphenylthiopurine;

[0125] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-isopropoxyphenylthiopurine;

[0126] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-isobutoxyphenylthiopurine;

[0127] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-butoxyphenylthiopurine;

[0128] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-propoxyphenylthiopurine;

[0129] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-isopropoxyphenylthiopurine;

[0130] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-isobutoxyphenylthiopurine;

[0131] 2-amino-9-2-(phosphonomethoxy)propyl-6-phenylthiopurine;

[0132] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-methoxyphenylthiopurine;

[0133] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-methoxyphenylthiopurine;

[0134] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-methoxyphenylthiopurine;

[0135] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-ethoxyphenylthiopurine;

[0136] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-ethoxyphenylthiopurine;

[0137] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-ethoxyphenylthiopurine;

[0138] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-ethoxyphenylthiopurine;

[0139] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-propoxyphenylthiopurine;

[0140] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-isobutoxyphenylthiopurine;

[0141] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-isobutoxyphenylthiopurine;

[0142] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-propoxyphenylthiopurine;

[0143] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-isobutoxyphenylthiopurine;

[0144] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-isobutoxyphenylthiopurine;

[0145] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-butoxyphenylthiopurine;

[0146] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-propoxyphenylthiopurine;

[0147] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-isopropoxyphenylthiopurine;

[0148] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-isobutoxyphenylthiopurine;

[0149] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-hydroxyphenylthiopurine;

[0150] 2-amino-9-2-(phosphonomethoxy)ethyl-6-p-hydroxyphenylthiopurine;

[0151] 2-amino-9-2-(phosphonomethoxy)ethyl-6-m-hydroxyphenylthiopurine;

[0152] 2-amino-9-2-(phosphonomethoxy)ethyl-6-o-hydroxyphenylthiopurine;

[0153] 2-amino-9-2-(phosphonomethoxy)propyl-6-p-hydroxyphenylthiopurine;

[0154] 2-amino-9-2-(phosphonomethoxy)propyl-6-m-hydroxyphenylthiopurine; and

[0155] 2-amino-9-2-(phosphonomethoxy)propyl-6-o-hydroxyphenylthiopurine.

[0156] The fifth condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₄ alkoxy group, each of R² and R³ is a 2,2,2-trifluoroethyl group, and R⁴ is a hydrogen atom or a methyl group. Specific examples of preferred compounds which satisfy this condition include:

[0157] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-phenylthiopurine;

[0158] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-methoxyphenylthiopurine;

[0159] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-methoxyphenylthiopurine;

[0160] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-methoxyphenylthiopurine;

[0161] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-ethoxyphenylthiopurine;

[0162] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-phenylthiopurine;

[0163] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-methoxyphenylthiopurine;

[0164] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-butoxyphenylthiopurine;

[0165] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-propoxyphenylthiopurine;

[0166] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isopropoxyphenylthiopurine;

[0167] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isobutoxyphenylthiopurine;

[0168] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-hydroxyphenylthiopurine;

[0169] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-hydroxyphenylthiopurine;

[0170] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-hydroxyphenylthiopurine;

[0171] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-hydroxyphenylthiopurine;

[0172] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-hydroxyphenylthiopurine; and

[0173] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-hydroxyphenylthiopurine.

[0174] Specific examples of other compounds which satisfy the fifth condition include:

[0175] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-ethoxyphenylthiopurine;

[0176] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-ethoxyphenylthiopurine;

[0177] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-butoxyphenylthiopurine;

[0178] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-propoxyphenylthiopurine;

[0179] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isopropoxyphenylthiopurine;

[0180] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isobutoxyphenylthiopurine;

[0181] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-butoxyphenylthiopurine;

[0182] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-propoxyphenylthiopurine;

[0183] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isopropoxyphenylthiopurine;

[0184] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isobutoxyphenylthiopurine;

[0185] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-methoxyphenylthiopurine;

[0186] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-methoxyphenylthiopurine;

[0187] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-ethoxyphenylthiopurine;

[0188] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-ethoxyphenylthiopurine;

[0189] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-ethoxyphenylthiopurine;

[0190] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-butoxyphenylthiopurine;

[0191] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-propoxyphenylthiopurine;

[0192] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isopropoxyphenylthiopurine;

[0193] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-p-isobutoxyphenylthiopurine;

[0194] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-butoxyphenylthiopurine;

[0195] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-propoxyphenylthiopurine;

[0196] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isopropoxyphenylthiopurine;

[0197] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-m-isobutoxyphenylthiopurine;

[0198] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-butoxyphenylthiopurine;

[0199] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-propoxyphenylthiopurine;

[0200] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isopropoxyphenylthiopurine; and

[0201] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxypropyl-6-o-isobutoxyphenylthiopurine.

[0202] The sixth condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₄ alkoxy group, each of R² and R³ is a 2,2,2-trifluoroethyl group, and R⁴ is a hydrogen atom. Specific examples of preferred compounds which satisfy this condition include:

[0203] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-phenylthiopurine;

[0204] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-methoxyphenylthiopurine;

[0205] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-methoxyphenylthiopurine;

[0206] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-methoxyphenylthiopurine;

[0207] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-ethoxyphenylthiopurine;

[0208] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-butoxyphenylthiopurine;

[0209] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-propoxyphenylthiopurine;

[0210] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isopropoxyphenylthiopurine;

[0211] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-isobutoxyphenylthiopurine;

[0212] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-hydroxyphenylthiopurine;

[0213] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-hydroxyphenylthiopurine; and

[0214] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-hydroxyphenylthiopurine.

[0215] Specific examples of other preferred compounds which satisfy the sixth condition include:

[0216] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-ethoxyphenylthiopurine;

[0217] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-ethoxyphenylthiopurine;

[0218] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-butoxyphenylthiopurine;

[0219] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-propoxyphenylthiopurine;

[0220] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isopropoxyphenylthiopurine;

[0221] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-isobutoxyphenylthiopurine;

[0222] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-butoxyphenylthiopurine;

[0223] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-propoxyphenylthiopurine;

[0224] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isopropoxyphenylthiopurine; and

[0225] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-isobutoxyphenylthiopurine.

[0226] The seventh condition for the preferred compound of the present invention is that R¹ is a hydrogen atom, a hydroxyl group or a C₁-C₂ alkoxy group, each of R² and R³ is a 2,2,2-trifluoroethyl group, and R⁴ is a hydrogen atom. Specific examples of preferred compounds which satisfy this condition include:

[0227] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-phenylthiopurine;

[0228] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-methoxyphenylthiopurine;

[0229] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-methoxyphenylthiopurine;

[0230] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-methoxyphenylthiopurine;

[0231] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-ethoxyphenylthiopurine;

[0232] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-p-hydroxyphenylthiopurine;

[0233] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-m-hydroxyphenylthiopurine; and

[0234] 2-amino-9-2-bis(2,2,2-trifluoroethyl)phosphonylmethoxyethyl-6-o-hydroxyphenylthiopurine.

[0235] The phosphonate nucleotide compounds of the formula (I) used in the present invention may exist as a salt, and any use of the salt formed by the above compound falls within the scope of the present invention. Examples of such a salt include a pharmaceutically acceptable salt. Where an acidic group exists, the acidic group is able to form metal salts such as a lithium salt, a sodium salt, a potassium salt, a magnesium salt and a calcium salt, and ammonium salts such as an ammonium salt, a methyl ammonium salt, a dimethyl ammonium salt, a trimethyl ammonium salt and dicyclohexyl ammonium salt. Where an amino group exists, the amino group is able to form mineral acid salts such as hydrochloride, hydrobromide, sulfate, nitrate, phosphate and metaphosphate, and organic acid salts such as methanesulfonate, benzenesulfonate, para-toluenesulfonate, acetate, propionate, tartrate, fumarate, maleate, malate, oxalate, succinate, citrate, benzoate, mandelate, cinnamate, lactate, besylate, valerate, stearate, oleate, lactobionate, ethylsuccinate, semisuccinate, butyrate, palmitate, carbamate, gluconate, laurate, salicylate, tannate and butylsulfonate.

[0236] The phosphonate nucleotide compounds of the formula (I) used in the present invention and a salt thereof may exist in the form of a hydrate or a solvate. Any hydrate or solvate formed by the phosphonate nucleotide compounds of the formula (I) used in the present invention and a salt thereof which include preferred compounds specifically shown above, falls within the scope of the present invention. Examples of a solvent capable of forming the solvate include methanol, ethanol, isopropanol, acetone, ethyl acetate, methylene chloride, diisopropyl ether and the like.

[0237] Specific examples of compounds used in the present invention are shown in Table 1-a, b (wherein Me- denotes a methyl group, Et- denotes an ethyl group, n-Pr-denotes an n-propyl group, i-Pr- denotes an isopropyl group, n-Bu denotes an n-butyl group, i-Bu denotes an isobutyl group, and t-Bu- denotes a tert-butyl group).

TABLE 1-a
No.	R1	R2	R3	R4	X
1	H	CF3CH2	CF3CH2	H	CH
2	o-OCH3	CF3CH2	CF3CH2	H	CH
3	m-OCH3	CF3CH2	CF3CH2	H	CH
4	p-OCH3	CF3CH2	CF3CH2	H	CH
5	o-Cl	CF3CH2	CF3CH2	H	CH
6	m-Cl	CF3CH2	CF3CH2	H	CH
7	p-Cl	CF3CH2	CF3CH2	H	CH
8	o-Br	CF3CH2	CF3CH2	H	CH
9	m-Br	CF3CH2	CF3CH2	H	CH
10	p-Br	CF3CH2	CF3CH2	H	CH
11	o-NH2	CF3CH2	CF3CH2	H	CH
12	m-NH2	CF3CH2	CF3CH2	H	CH
13	p-NH2	CF3CH2	CF3CH2	H	CH
14	o-NO2	CF3CH2	CF3CH2	H	CH
15	m-NO2	CF3CH2	CF3CH2	H	CH
16	p-NO2	CF3CH2	CF3CH2	H	CH
17	o-OC2H5	CF3CH2	CF3CH2	H	CH
18	m-OC2H5	CF3CH2	CF3CH2	H	CH
19	p-OC2H5	CF3CH2	CF3CH2	H	CH
20	p-I	CF3CH2	CF3CH2	H	CH
21	o-O-n-Pr	CF3CH2	CF3CH2	H	CH
22	m-O-n-Pr	CF3CH2	CF3CH2	H	CH
23	p-O-n-Pr	CF3CH2	CF3CH2	H	CH
24	o-O-i-Pr	CF3CH2	CF3CH2	H	CH
25	m-O-i-Pr	CF3CH2	CF3CH2	H	CH
26	p-O-i-Pr	CF3CH2	CF3CH2	H	CH
27	o-O-n-Bu	CF3CH2	CF3CH2	H	CH
28	m-O-n-Bu	CF3CH2	CF3CH2	H	CH
29	p-O-n-Bu	CF3CH2	CF3CH2	H	CH
30	o-O-i-Bu	CF3CH2	CF3CH2	H	CH
31	m-O-i-Bu	CF3CH2	CF3CH2	H	CH
32	p-O-i-Bu	CF3CH2	CF3CH2	H	CH
33	o-OCF3	CF3CH2	CF3CH2	H	CH
34	m-OCF3	CF3CH2	CF3CH2	H	CH
35	p-OCF3	CF3CH2	CF3CH2	H	CH
36	H	CF3CH2	CF3CH2	H	N
37	o-OCH3	CF3CH2	CF3CH2	H	N
38	m-OCH3	CF3CH2	CF3CH2	H	N
39	p-OCH3	CF3CH2	CF3CH2	H	N
40	o-Cl	CF3CH2	CF3CH2	H	N
41	m-Cl	CF3CH2	CF3CH2	H	N
42	p-Cl	CF3CH2	CF3CH2	H	N
43	o-Br	CF3CH2	CF3CH2	H	N
44	m-Br	CF3CH2	CF3CH2	H	N
45	p-Br	CF3CH2	CF3CH2	H	N
46	o-NH2	CF3CH3-	CF3CH2	H	N
47	m-NH2	CF3CH2	CF3CH2	H	N
48	p-NH2	CF3CH2	CF3CH2	H	N
49	o-NO2	CF3CH2	CF3CH2	H	N
50	m-NO2	CF3CH2	CF3CH2	H	N
51	p-NO2	CF3CH2	CF3CH2	H	N
52	o-OC2H5	CF3CH2	CF3CH2	H	N
53	m-OC2H5	CF3CH2	CF3CH2	H	N
54	p-OC2H5	CF3CH2	CF3CH2	H	N
55	p-I	CF3CH2	CF3CH2	H	N
56	o-O-n-Pr	CF3CH2	CF3CH2	H	N
57	m-O-n-Pr	CF3CH2	CF3CH2	H	N
58	p-O-n-Pr	CF3CH2	CF3CH2	H	N
59	o-O-i-Pr	CF3CH2	CF3CH2	H	N
60	m-O-i-Pr	CF3CH2	CF3CH2	H	N
61	p-O-i-Pr	CF3CH2	CF3CH2	H	N
62	o-O-n-Bu	CF3CH2	CF3CH2	H	N
63	m-O-n-Bu	CF3CH2	CF3CH2	H	N
64	p-O-n-Bu	CF3CH2	CF3CH2	H	N
65	o-O-i-Bu	CF3CH2	CF3CH2	H	N
66	m-O-i-Bu	CF3CH2	CF3CH2	H	N
67	p-O-i-Bu	CF3CH2	CF3CH2	H	N
68	o-OCF3	CF3CH2	CF3CH2	H	N
69	m-OCF3	CF3CH2	CF3CH2	H	N
70	p-OCF3	CF3CH2	CF3CH2	H	N
71	H	CF3CH2	Me	H	CH
72	o-OCH3	CF3CH2	Me	H	CH
73	m-OCH3	CF3CH2	Me	H	CH
74	p-OCH3	CF3CH2	Me	H	CH
75	o-Cl	CF3CH2	Me	H	CH
76	m-Cl	CF3CH2	Me	H	CH
77	p-Cl	CF3CH2	Me	H	CH
78	o-Br	CF3CH2	Me	H	CH
79	m-Br	CF3CH2	Me	H	CH
80	p-Br	CF3CH2	Me	H	CH
81	o-NH2	CF3CH2	Me	H	CH
82	m-NH2	CF3CH2	Me	H	CH
83	p-NH2	CF3CH2	Me	H	CH
84	o-NO2	CF3CH2	Me	H	CH
85	m-NO2	CF3CH2	Me	H	CH
86	p-NO2	CF3CH2	Me	H	CH
87	o-OC2H5	CF3CH2	Me	H	CH
88	m-OC2H5	CF3CH2	Me	H	CH
89	p-OC2H5	CF3CH2	Me	H	CH
90	p-I	CF3CH2	Me	H	CH
91	o-O-n-Pr	CF3CH2	Me	H	CH
92	m-O-n-Pr	CF3CH2	Me	H	CH
93	p-O-n-Pr	CF3CH2	Me	H	CH
94	o-O-i-Pr	CF3CH2	Me	H	CH
95	m-O-i-Pr	CF3CH2	Me	H	CH
96	p-O-i-Pr	CF3CH2	Me	H	CH
97	o-O-n-Bu	CF3CH2	Me	H	CH
98	m-O-n-Bu	CF3CH2	Me	H	CH
99	p-O-n-Bu	CF3CH2	Me	H	CH
100	o-O-i-Bu	CF3CH2	Me	H	CH
101	m-O-i-Bu	CF3CH2	Me	H	CH
102	p-O-i-Bu	CF3CH2	Me	H	CH
103	o-OCF3	CF3CH2	Me	H	CH
104	m-OCF3	CF3CH2	Me	H	CH
105	p-OCF3	CF3CH2	Me	H	CH
106	H	CF3CH2	Me	H	N
107	o-OCH3	CF3CH2	Me	H	N
108	m-OCH3	CF3CH2	Me	H	N
109	p-OCH3	CF3CH2	Me	H	N
110	o-Cl	CF3CH2	Me	H	N
111	m-Cl	CF3CH2	Me	H	N
112	p-Cl	CF3CH2	Me	H	N
113	o-Br	CF3CH2	Me	H	N
114	m-Br	CF3CH2	Me	H	N
115	p-Br	CF3CH2	Me	H	N
116	o-NH2	CF3CH2	Me	H	N
117	m-NH2	CF3CH2	Me	H	N
118	p-NH2	CF3CH2	Me	H	N
119	o-NO2	CF3CH2	Me	H	N
120	m-NO2	CF3CH2	Me	H	N
121	p-NO2	CF3CH2	Me	H	N
122	o-OC2H5	CF3CH2	Me	H	N
123	m-OC2H5	CF3CH2	Me	H	N
124	p-OC2H5	CF3CH2	Me	H	N
125	p-I	CF3CH2	Me	H	N
126	o-O-n-Pr	CF3CH2	Me	H	N
127	m-O-n-Pr	CF3CH2	Me	H	N
128	p-O-n-Pr	CF3CH2	Me	H	N
129	o-O-i-Pr	CF3CH2	Me	H	N
130	m-O-i-Pr	CF3CH2	Me	H	N
131	p-O-i-Pr	CF3CH2	Me	H	N
132	o-O-n-Bu	CF3CH2	Me	H	N
133	m-O-n-Bu	CF3CH2	Me	H	N
134	p-O-n-Bu	CF3CH2	Me	H	N
135	o-O-i-Bu	CF3CH2	Me	H	N
136	m-O-i-Bu	CF3CH2	Me	H	N
137	p-O-i-Bu	CF3CH2	Me	H	N
138	o-OCF3	CF3CH2	Me	H	N
139	m-OCF3	CF3CH2	Me	H	N
140	p-OCF3	CF3CH2	Me	H	N
141	H	CF3CH2	Et	H	CH
142	o-OCH3	CF3CH2	Et	H	CH
143	m-OCH3	CF3CH2	Et	H	CH
144	p-OCH3	CF3CH2	Et	H	CH
145	o-Cl	CF3CH2	Et	H	CH
146	m-Cl	CF3CH2	Et	H	CH
147	p-Cl	CF3CH2	Et	H	CH
148	o-Br	CF3CH2	Et	H	CH
149	m-Br	CF3CH2	Et	H	CH
150	p-Br	CF3CH2	Et	H	CH
151	o-NH2	CF3CH2	Et	H	CH
152	m-NH2	CF3CH2	Et	H	CH
153	p-NH2	CF3CH2	Et	H	CH
154	o-NO2	CF3CH2	Et	H	CH
155	m-NO2	CF3CH2	Et	H	CH
156	p-NO2	CF3CH2	Et	H	CH
157	o-OC2H5	CF3CH2	Et	H	CH
158	m-OC2H5	CF3CH2	Et	H	CH
159	p-OC2H5	CF3CH2	Et	H	CH
160	p-I	CF3CH2	Et	H	CH
161	o-O-n-Pr	CF3CH2	Et	H	CH
162	m-O-n-Pr	CF3CH2	Et	H	CH
163	p-O-n-Pr	CF3CH2	Et	H	CH
164	o-O-i-Pr	CF3CH2	Et	H	CH
165	m-O-i-Pr	CF3CH2	Et	H	CH
166	p-O-i-Pr	CF3CH2	Et	H	CH
167	o-O-n-Bu	CF3CH2	Et	H	CH
168	m-O-n-Bu	CF3CH2	Et	H	CH
169	p-O-n-Bu	CF3CH2	Et	H	CH
170	o-O-i-Bu	CF3CH2	Et	H	CH
171	m-O-i-Bu	CF3CH2	Et	H	CH
172	p-O-i-Bu	CF3CH2	Et	H	CH
173	o-OCF3	CF3CH2	Et	H	CH
174	m-OCF3	CF3CH2	Et	H	CH
175	p-OCF3	CF3CH2	Et	H	CH
176	H	CF3CH2	Et	H	N
177	o-OCH3	CF3CH2	Et	H	N
178	m-OCH3	CF3CH2	Et	H	N
179	p-OCH3	CF3CH2	Et	H	N
180	o-Cl	CF3CH2	Et	H	N
181	m-Cl	CF3CH2	Et	H	N
182	p-Cl	CF3CH2	Et	H	N
183	o-Br	CF3CH2	Et	H	N
184	m-Br	CF3CH2	Et	H	N
185	p-Br	CF3CH2	Et	H	N
186	o-NH2	CF3CH2	Et	H	N
187	m-NH2	CF3CH2	Et	H	N
188	p-NH2	CF3CH2	Et	H	N
189	o-NO2	CF3CH2	Et	H	N
190	m-NO2	CF3CH2	Et	H	N
191	p-NO2	CF3CH2	Et	H	N
192	o-OC2H5	CF3CH2	Et	H	N
193	m-OC2H5	CF3CH2	Et	H	N
194	p-OC2H5	CF3CH2	Et	H	N
195	p-I	CF3CH2	Et	H	N
196	o-O-n-Pr	CF3CH2	Et	H	N
197	m-O-n-Pr	CF3CH2	Et	H	N
198	p-O-n-Pr	CF3CH2	Et	H	N
199	o-O-i-Pr	CF3CH2	Et	H	N
200	m-O-i-Pr	CF3CH2	Et	H	N
201	p-O-i-Pr	CF3CH2	Et	H	N
202	o-O-n-Bu	CF3CH2	Et	H	N
203	m-O-n-Bu	CF3CH2	Et	H	N
204	p-O-n-Bu	CF3CH2	Et	H	N
205	o-O-i-Bu	CF3CH2	Et	H	N
206	m-O-i-Bu	CF3CH2	Et	H	N
207	p-O-i-Bu	CF3CH2	Et	H	N
208	o-OCF3	CF3CH2	Et	H	N
209	m-OCF3	CF3CH2	Et	H	N
210	p-OCF3	CF3CH2	Et	H	N
211	H	CF3CH2	H	H	CH
212	o-OCH3	CF3CH2	H	H	CH
213	m-OCH3	CF3CH2	H	H	CH
214	p-OCH3	CF3CH2	H	H	CH
215	o-Cl	CF3CH2	H	H	CH
216	m-Cl	CF3CH2	H	H	CH
217	p-Cl	CF3CH2	H	H	CH
218	o-Br	CF3CH2	H	H	CH
219	m-Br	CF3CH2	H	H	CH
220	p-Br	CF3CH2	H	H	CH
221	o-NH2	CF3CH2	H	H	CH
222	m-NH2	CF3CH2	H	H	CH
223	p-NH2	CF3CH2	H	H	CH
224	o-NO2	CF3CH2	H	H	CH
225	m-NO2	CF3CH2	H	H	CH
226	p-NO2	CF3CH2	H	H	CH
227	o-OC2H5	CF3CH2	H	H	CH
228	m-OC2H5	CF3CH2	H	H	CH
229	p-OC2H5	CF3CH2	H	H	CH
230	p-I	CF3CH2	H	H	CH
231	o-O-n-Pr	CF3CH2	H	H	CH
232	m-O-n-Pr	CF3CH2	H	H	CH
233	p-O-n-Pr	CF3CH2	H	H	CH
234	o-O-i-Pr	CF3CH2	H	H	CH
235	m-O-i-Pr	CF3CH2	H	H	CH
236	p-O-i-Pr	CF3CH2	H	H	CH
237	o-O-n-Bu	CF3CH2	H	H	CH
238	m-O-n-Bu	CF3CH2	H	H	CH
239	p-O-n-Bu	CF3CH2	H	H	CH
240	o-O-i-Bu	CF3CH2	H	H	CH
241	m-O-i-Bu	CF3CH2	H	H	CH
242	p-O-i-Bu	CF3CH2	H	H	CH
243	o-OCF3	CF3CH2	H	H	CH
244	m-OCF3	CF3CH2	H	H	CH
245	p-OCF3	CF3CH2	H	H	CH
246	H	CF3CH2	H	H	N
247	o-OCH3	CF3CH2	H	H	N
248	m-OCH3	CF3CH2	H	H	N
249	p-OCH3	CF3CH2	H	H	N
250	o-Cl	CF3CH2	H	H	N
251	m-Cl	CF3CH2	H	H	N
252	p-Cl	CF3CH2	H	H	N
253	o-Br	CF3CH2	H	H	N
254	m-Br	CF3CH2	H	H	N
255	p-Br	CF3CH2	H	H	N
256	o-NH2	CF3CH2	H	H	N
257	m-NH2	CF3CH2	H	H	N
258	p-NH2	CF3CH2	H	H	N
259	o-NO2	CF3CH2	H	H	N
260	m-NO2	CF3CH2	H	H	N
261	p-NO2	CF3CH2	H	H	N
262	o-OC2H5	CF3CH2	H	H	N
263	m-OC2H5	CF3CH2	H	H	N
264	p-OC2H5	CF3CH2	H	H	N
265	p-I	CF3CH2	H	H	N
266	o-O-n-Pr	CF3CH2	H	H	N
267	m-O-n-Pr	CF3CH2	H	H	N
268	p-O-n-Pr	CF3CH2	H	H	N
269	o-O-i-Pr	CF3CH2	H	H	N
270	m-O-i-Pr	CF3CH2	H	H	N
271	p-O-i-Pr	CF3CH2	H	H	N
272	o-O-n-Bu	CF3CH2	H	H	N
273	m-O-n-Bu	CF3CH2	H	H	N
274	p-O-n-Bu	CF3CH2	H	H	N
275	o-O-i-Bu	CF3CH2	H	H	N
276	m-O-i-Bu	CF3CH2	H	H	N
277	p-O-i-Bu	CF3CH2	H	H	N
278	o-OCF3	CF3CH2	H	H	N
279	m-OCF3	CF3CH2	H	H	N
280	p-OCF3	CF3CH2	H	H	N
281	H	H	H	H	CH
282	o-OCH3	H	H	H	CH
283	m-OCH3	H	H	H	CH
284	p-OCH3	H	H	H	CH
285	o-Cl	H	H	H	CH
286	m-Cl	H	H	H	CH
287	p-Cl	H	H	H	CH
288	o-Br	H	H	H	CH
289	m-Br	H	H	H	CH
290	p-Br	H	H	H	CH
291	o-NH2	H	H	H	CH
292	m-NH2	H	H	H	CH
293	p-NH2	H	H	H	CH
294	o-NO2	H	H	H	CH
295	m-NO2	H	H	H	CH
296	p-NO2	H	H	H	CH
297	o-OC2H5	H	H	H	CH
298	m-OC2H5	H	H	H	CH
299	p-OC2H5	H	H	H	CH
300	p-I	H	H	H	CH
301	o-O-n-Pr	H	H	H	CH
302	m-O-n-Pr	H	H	H	CH
303	p-O-n-Pr	H	H	H	CH
304	o-O-i-Pr	H	H	H	CH
305	m-O-i-Pr	H	H	H	CH
306	p-O-i-Pr	H	H	H	CH
307	o-O-n-Bu	H	H	H	CH
308	m-O-n-Bu	H	H	H	CH
309	p-O-n-Bu	H	H	H	CH
310	o-O-i-Bu	H	H	H	CH
311	m-O-i-Bu	H	H	H	CH
312	p-O-i-Bu	H	H	H	CH
313	o-OCF3	H	H	H	CH
314	m-OCF3	H	H	H	CH
315	p-OCF3	H	H	H	CH
316	H	H	H	H	N
317	o-OCH3	H	H	H	N
318	m-OCH3	H	H	H	N
319	p-OCH3	H	H	H	N
320	o-Cl	H	H	H	N
321	m-Cl	H	H	H	N
322	p-Cl	H	H	H	N
323	o-Br	H	H	H	N
324	m-Br	H	H	H	N
325	p-Br	H	H	H	N
326	o-NH2	H	H	H	N
327	m-NH2	H	H	H	N
328	p-NH2	H	H	H	N
329	o-NO2	H	H	H	N
330	m-NO2	H	H	H	N
331	p-NO2	H	H	H	N
332	o-OC2H5	H	H	H	N
333	m-OC2H5	H	H	H	N
334	p-OC2H5	H	H	H	N
335	p-I	H	H	H	N
336	o-O-n-Pr	H	H	H	N
337	m-O-n-Pr	H	H	H	N
338	p-O-n-Pr	H	H	H	N
339	o-O-i-Pr	H	H	H	N
340	m-O-i-Pr	H	H	H	N
341	p-O-i-Pr	H	H	H	N
342	o-O-n-Bu	H	H	H	N
343	m-O-n-Bu	H	H	H	N
344	p-O-n-Bu	H	H	H	N
345	o-O-i-Bu	H	H	H	N
346	m-O-i-Bu	H	H	H	N
347	p-O-i-Bu	H	H	H	N
348	o-OCF3	H	H	H	N
349	m-OCF3	H	H	H	N
350	p-OCF3	H	H	H	N
351	H	CF3CH2	CF3CH2	Me	CH
352	o-OCH3	CF3CH2	CF3CH2	Me	CH
353	m-OCH3	CF3CH2	CF3CH2	Me	CH
354	p-OCH3	CF3CH2	CF3CH2	Me	CH
355	o-Cl	CF3CH2	CF3CH2	Me	CH
356	m-Cl	CF3CH2	CF3CH2	Me	CH
357	p-Cl	CF3CH2	CF3CH2	Me	CH
358	o-Br	CF3CH2	CF3CH2	Me	CH
359	m-Br	CF3CH2	CF3CH2	Me	CH
360	p-Br	CF3CH2	CF3CH2	Me	CH
361	o-NH2	CF3CH2	CF3CH2	Me	CH
362	m-NH2	CF3CH2	CF3CH2	Me	CH
363	p-NH2	CF3CH2	CF3CH2	Me	CH
364	o-NO2	CF3CH2	CF3CH2	Me	CH
365	m-NO2	CF3CH2	CF3CH2	Me	CH
366	p-NO2	CF3CH2	CF3CH2	Me	CH
367	o-OC2H5	CF3CH2	CF3CH2	Me	CH
368	m-OC2H5	CF3CH2	CF3CH2	Me	CH
369	p-OC2H5	CF3CH2	CF3CH2	Me	CH
370	p-I	CF3CH2	CF3CH2	Me	CH
371	o-O-n-Pr	CF3CH2	CF3CH2	Me	CH
372	m-O-n-Pr	CF3CH2	CF3CH2	Me	CH
373	p-O-n-Pr	CF3CH2	CF3CH2	Me	CH
374	o-O-i-Pr	CF3CH2	CF3CH2	Me	CH
375	m-O-i-Pr	CF3CH2	CF3CH2	Me	CH
376	p-O-i-Pr	CF3CH2	CF3CH2	Me	CH
377	o-O-n-Bu	CF3CH2	CF3CH2	Me	CH
378	m-O-n-Bu	CF3CH2	CF3CH2	Me	CH
379	p-O-n-Bu	CF3CH2	CF3CH2	Me	CH
380	o-O-i-Bu	CF3CH2	CF3CH2	Me	CH
381	m-O-i-Bu	CF3CH2	CF3CH2	Me	CH
382	p-O-i-Bu	CF3CH2	CF3CH2	Me	CH
383	o-OCF3	CF3CH2	CF3CH2	Me	CH
384	m-OCF3	CF3CH2	CF3CH2	Me	CH
385	p-OCF3	CF3CH2	CF3CH2	Me	CH
386	H	CF3CH2	CF3CH2	Me	N
387	o-OCH3	CF3CH2	CF3CH2	Me	N
388	m-OCH3	CF3CH2	CF3CH2	Me	N
389	p-OCH3	CF3CH2	CF3CH2	Me	N
390	o-Cl	CF3CH2	CF3CH2	Me	N
391	m-Cl	CF3CH2	CF3CH2	Me	N
392	p-Cl	CF3CH2	CF3CH2	Me	N
393	o-Br	CF3CH2	CF3CH2	Me	N
394	m-Br	CF3CH2	CF3CH2	Me	N
395	p-Br	CF3CH2	CF3CH2	Me	N
396	o-NH2	CF3CH2	CF3CH2	Me	N
397	m-NH2	CF3CH2	CF3CH2	Me	N
398	p-NH2	CF3CH2	CF3CH2	Me	N
399	o-NO2	CF3CH2	CF3CH2	Me	N
400	m-NO2	CF3CH2	CF3CH2	Me	N
401	p-NO2	CF3CH2	CF3CH2	Me	N
402	o-OC2H5	CF3CH2	CF3CH2	Me	N
403	m-OC2H5	CF3CH2	CF3CH2	Me	N
404	p-OC2H5	CF3CH2	CF3CH2	Me	N
405	p-I	CF3CH2	CF3CH2	Me	N
406	o-O-n-Pr	CF3CH2	CF3CH2	Me	N
407	m-O-n-Pr	CF3CH2	CF3CH2	Me	N
408	p-O-n-Pr	CF3CH2	CF3CH2	Me	N
409	o-O-i-Pr	CF3CH2	CF3CH2	Me	N
410	m-O-i-Pr	CF3CH2	CF3CH2	Me	N
411	p-O-i-Pr	CF3CH2	CF3CH2	Me	N
412	o-O-n-Bu	CF3CH2	CF3CH2	Me	N
413	m-O-n-Bu	CF3CH2	CF3CH2	Me	N
414	p-O-n-Bu	CF3CH2	CF3CH2	Me	N
415	o-O-i-Bu	CF3CH2	CF3CH2	Me	N
416	m-O-i-Bu	CF3CH2	CF3CH2	Me	N
417	p-O-i-Bu	CF3CH2	CF3CH2	Me	N
418	o-OCF3	CF3CH2	CF3CH2	Me	N
419	m-OCF3	CF3CH2	CF3CH2	Me	N
420	p-OCF3	CF3CH2	CF3CH2	Me	N
421	H	CF3CH2	Me	Me	CH
422	o-OCH3	CF3CH2	Me	Me	CH
423	m-OCH3	CF3CH2	Me	Me	CH
424	p-OCH3	CF3CH2	Me	Me	CH
425	o-Cl	CF3CH2	Me	Me	CH
426	m-Cl	CF3CH2	Me	Me	CH
427	p-Cl	CF3CH2	Me	Me	CH
428	o-Br	CF3CH2	Me	Me	CH
429	m-Br	CF3CH2	Me	Me	CH
430	p-Br	CF3CH2	Me	Me	CH
431	o-NH2	CF3CH2	Me	Me	CH
432	m-NH2	CF3CH2	Me	Me	CH
433	p-NH2	CF3CH2	Me	Me	CH
434	o-NO2	CF3CH2	Me	Me	CH
435	m-NO2	CF3CH2	Me	Me	CH
436	p-NO2	CF3CH2	Me	Me	CH
437	o-OC2H5	CF3CH2	Me	Me	CH
438	m-OC2H5	CF3CH2	Me	Me	CH
439	p-OC2H5	CF3CH2	Me	Me	CH
440	p-I	CF3CH2	Me	Me	CH
441	o-O-n-Pr	CF3CH2	Me	Me	CH
442	m-O-n-Pr	CF3CH2	Me	Me	CH
443	p-O-n-Pr	CF3CH2	Me	Me	CH
444	o-O-i-Pr	CF3CH2	Me	Me	CH
445	m-O-i-Pr	CF3CH2	Me	Me	CH
446	p-O-i-Pr	CF3CH2	Me	Me	CH
447	o-O-n-Bu	CF3CH2	Me	Me	CH
448	m-O-n-Bu	CF3CH2	Me	Me	CH
449	p-O-n-Bu	CF3CH2	Me	Me	CH
450	o-O-i-Bu	CF3CH2	Me	Me	CH
451	m-O-i-Bu	CF3CH2	Me	Me	CH
452	p-O-i-Bu	CF3CH2	Me	Me	CH
453	o-OCF3	CF3CH2	Me	Me	CH
454	m-OCF3	CF3CH2	Me	Me	CH
455	p-OCF3	CF3CH2	Me	Me	CH
456	H	CF3CH2	Me	Me	N
457	o-OCH3	CF3CH2	Me	Me	N
458	m-OCH3	CF3CH2	Me	Me	N
459	p-OCH3	CF3CH2	Me	Me	N
460	o-Cl	CF3CH2	Me	Me	N
461	m-Cl	CF3CH2	Me	Me	N
462	p-Cl	CF3CH2	Me	Me	N
463	o-Br	CF3CH2	Me	Me	N
464	m-Br	CF3CH2	Me	Me	N
465	p-Br	CF3CH2	Me	Me	N
466	o-NH2	CF3CH2	Me	Me	N
467	m-NH2	CF3CH2	Me	Me	N
468	p-NH2	CF3CH2	Me	Me	N
469	o-NO2	CF3CH2	Me	Me	N
470	m-NO2	CF3CH2	Me	Me	N
471	p-NO2	CF3CH2	Me	Me	N
472	o-OC2H5	CF3CH2	Me	Me	N
473	m-OC2H5	CF3CH2	Me	Me	N
474	p-OC2H5	CF3CH2	Me	Me	N
475	p-I	CF3CH2	Me	Me	N
476	o-O-n-Pr	CF3CH2	Me	Me	N
477	m-O-n-Pr	CF3CH2	Me	Me	N
478	p-O-n-Pr	CF3CH2	Me	Me	N
479	o-O-i-Pr	CF3CH2	Me	Me	N
480	m-O-i-Pr	CF3CH2	Me	Me	N
481	p-O-i-Pr	CF3CH2	Me	Me	N
482	o-O-n-Bu	CF3CH2	Me	Me	N
483	m-O-n-Bu	CF3CH2	Me	Me	N
484	p-O-n-Bu	CF3CH2	Me	Me	N
485	o-O-i-Bu	CF3CH2	Me	Me	N
486	m-O-i-Bu	CF3CH2	Me	Me	N
487	p-O-i-Bu	CF3CH2	Me	Me	N
488	o-OCF3	CF3CH2	Me	Me	N
489	m-OCF3	CF3CH2	Me	Me	N
490	p-OCF3	CF3CH2	Me	Me	N
491	H	CF3CH2	Et	Me	CH
492	o-OCH3	CF3CH2	Et	Me	CH
493	m-OCH3	CF3CH2	Et	Me	CH
494	p-OCH3	CF3CH2	Et	Me	CH
495	o-Cl	CF3CH2	Et	Me	CH
496	m-Cl	CF3CH2	Et	Me	CH
497	p-Cl	CF3CH2	Et	Me	CH
498	o-Br	CF3CH2	Et	Me	CH
499	m-Br	CF3CH2	Et	Me	CH
500	p-Br	CF3CH2	Et	Me	CH
501	o-NH2	CF3CH2	Et	Me	CH
502	m-NH2	CF3CH2	Et	Me	CH
503	p-NH2	CF3CH2	Et	Me	CH
504	o-NO2	CF3CH2	Et	Me	CH
505	m-NO2	CF3CH2	Et	Me	CH
506	p-NO2	CF3CH2	Et	Me	CH
507	o-OC2H5	CF3CH2	Et	Me	CH
508	m-OC2H5	CF3CH2	Et	Me	CH
509	p-OC2H5	CF3CH2	Et	Me	CH
510	p-I	CF3CH2	Et	Me	CH
511	o-O-n-Pr	CF3CH2	Et	Me	CH
512	m-O-n-Pr	CF3CH2	Et	Me	CH
513	p-O-n-Pr	CF3CH2	Et	Me	CH
514	o-O-i-Pr	CF3CH2	Et	Me	CH
515	m-O-i-Pr	CF3CH2	Et	Me	CH
516	p-O-i-Pr	CF3CH2	Et	Me	CH
517	o-O-n-Bu	CF3CH2	Et	Me	CH
518	m-O-n-Bu	CF3CH2	Et	Me	CH
519	p-O-n-Bu	CF3CH2	Et	Me	CH
520	o-O-i-Bu	CF3CH2	Et	Me	CH
521	m-O-i-Bu	CF3CH2	Et	Me	CH
522	p-O-i-Bu	CF3CH2	Et	Me	CH
523	o-OCF3	CF3CH2	Et	Me	CH
524	m-OCF3	CF3CH2	Et	Me	CH
525	p-OCF3	CF3CH2	Et	Me	CH
526	H	CF3CH2	Et	Me	N
527	o-OCH3	CF3CH2	Et	Me	N
528	m-OCH3	CF3CH2	Et	Me	N
529	p-OCH3	CF3CH2	Et	Me	N
530	o-Cl	CF3CH2	Et	Me	N
531	m-Cl	CF3CH2	Et	Me	N
532	p-Cl	CF3CH2	Et	Me	N
533	o-Br	CF3CH2	Et	Me	N
534	m-Br	CF3CH2	Et	Me	N
535	p-Br	CF3CH2	Et	Me	N
536	o-NH2	CF3CH2	Et	Me	N
537	m-NH2	CF3CH2	Et	Me	N
538	p-NH2	CF3CH2	Et	Me	N
539	o-NO2	CF3CH2	Et	Me	N
540	m-NO2	CF3CH2	Et	Me	N
541	p-NO2	CF3CH2	Et	Me	N
542	o-OC2H5	CF3CH2	Et	Me	N
543	m-OC2H5	CF3CH2	Et	Me	N
544	p-OC2H5	CF3CH2	Et	Me	N
545	p-I	CF3CH2	Et	Me	N
546	o-O-n-Pr	CF3CH2	Et	Me	N
547	m-O-n-Pr	CF3CH2	Et	Me	N
548	p-O-n-Pr	CF3CH2	Et	Me	N
549	o-O-i-Pr	CF3CH2	Et	Me	N
550	m-O-i-Pr	CF3CH2	Et	Me	N
551	p-O-i-Pr	CF3CH2	Et	Me	N
552	o-O-n-Bu	CF3CH2	Et	Me	N
553	m-O-n-Bu	CF3CH2	Et	Me	N
554	p-O-n-Bu	CF3CH2	Et	Me	N
555	o-O-i-Bu	CF3CH2	Et	Me	N
556	m-O-i-Bu	CF3CH2	Et	Me	N
557	p-O-i-Bu	CF3CH2	Et	Me	N
558	o-OCF3	CF3CH2	Et	Me	N
559	m-OCF3	CF3CH2	Et	Me	N
560	p-OCF3	CF3CH2	Et	Me	N
561	H	CF3CH2	H	Me	CH
562	o-OCH3	CF3CH2	H	Me	CH
563	m-OCH3	CF3CH2	H	Me	CH
564	p-OCH3	CF3CH2	H	Me	CH
565	o-Cl	CF3CH2	H	Me	CH
566	m-Cl	CF3CH2	H	Me	CH
567	p-Cl	CF3CH2	H	Me	CH
568	o-Br	CF3CH2	H	Me	CH
569	m-Br	CF3CH2	H	Me	CH
570	p-Br	CF3CH2	H	Me	CH
571	o-NH2	CF3CH2	H	Me	CH
572	m-NH2	CF3CH2	H	Me	CH
573	p-NH2	CF3CH2	H	Me	CH
574	o-NO2	CF3CH2	H	Me	CH
575	m-NO2	CF3CH2	H	Me	CH
576	p-NO2	CF3CH2	H	Me	CH
577	o-OC2H5	CF3CH2	H	Me	CH
578	m-OC2H5	CF3CH2	H	Me	CH
579	p-OC2H5	CF3CH2	H	Me	CH
580	p-I	CF3CH2	H	Me	CH
581	o-O-n-Pr	CF3CH2	H	Me	CH
582	m-O-n-Pr	CF3CH2	H	Me	CH
583	p-O-n-Pr	CF3CH2	H	Me	CH
584	o-O-i-Pr	CF3CH2	H	Me	CH
585	m-O-i-Pr	CF3CH2	H	Me	CH
586	p-O-i-Pr	CF3CH2	H	Me	CH
587	o-O-n-Bu	CF3CH2	H	Me	CH
588	m-O-n-Bu	CF3CH2	H	Me	CH
589	p-O-n-Bu	CF3CH2	H	Me	CH
590	o-O-i-Bu	CF3CH2	H	Me	CH
591	m-O-i-Bu	CF3CH2	H	Me	CH
592	p-O-i-Bu	CF3CH2	H	Me	CH
593	o-OCF3	CF3CH2	H	Me	CH
594	m-OCF3	CF3CH2	H	Me	CH
595	p-OCF3	CF3CH2	H	Me	CH
596	H	CF3CH2	H	Me	N
597	o-OCH3	CF3CH2	H	Me	N
598	m-OCH3	CF3CH2	H	Me	N
599	p-OCH3	CF3CH2	H	Me	N
600	o-Cl	CF3CH2	H	Me	N
601	m-Cl	CF3CH2	H	Me	N
602	p-Cl	CF3CH2	H	Me	N
603	o-Br	CF3CH2	H	Me	N
604	m-Br	CF3CH2	H	Me	N
605	p-Br	CF3CH2	H	Me	N
606	o-NH2	CF3CH2	H	Me	N
607	m-NH2	CF3CH2	H	Me	N
608	p-NH2	CF3CH2	H	Me	N
609	o-NO2	CF3CH2	H	Me	N
610	m-NO2	CF3CH2	H	Me	N
611	p-NO2	CF3CH2	H	Me	N
612	o-OC2H5	CF3CH2	H	Me	N
613	m-OC2H5	CF3CH2	H	Me	N
614	p-OC2H5	CF3CH2	H	Me	N
615	p-I	CF3CH2	H	Me	N
616	o-O-n-Pr	CF3CH2	H	Me	N
617	m-O-n-Pr	CF3CH2	H	Me	N
618	p-O-n-Pr	CF3CH2	H	Me	N
619	o-O-i-Pr	CF3CH2	H	Me	N
620	m-O-i-Pr	CF3CH2	H	Me	N
621	p-O-i-Pr	CF3CH2	H	Me	N
622	o-O-n-Bu	CF3CH2	H	Me	N
623	m-O-n-Bu	CF3CH2	H	Me	N
624	p-O-n-Bu	CF3CH2	H	Me	N
625	o-O-i-Bu	CF3CH2	H	Me	N
626	m-O-i-Bu	CF3CH2	H	Me	N
627	p-O-i-Bu	CF3CH2	H	Me	N
628	o-OCF3	CF3CH2	H	Me	N
629	m-OCF3	CF3CH2	H	Me	N
630	p-OCF3	CF3CH2	H	Me	N
631	H	H	H	Me	CH
632	o-OCH3	H	H	Me	CH
633	m-OCH3	H	H	Me	CH
634	p-OCH3	H	H	Me	CH
635	o-Cl	H	H	Me	CH
636	m-Cl	H	H	Me	CH
637	p-Cl	H	H	Me	CH
638	o-Br	H	H	Me	CH
639	m-Br	H	H	Me	CH
640	p-Br	H	H	Me	CH
641	o-NH2	H	H	Me	CH
642	m-NH2	H	H	Me	CH
643	p-NH2	H	H	Me	CH
644	o-NO2	H	H	Me	CH
645	m-NO2	H	H	Me	CH
646	p-NO2	H	H	Me	CH
647	o-OC2H5	H	H	Me	CH
648	m-OC2H5	H	H	Me	CH
649	p-OC2H5	H	H	Me	CH
650	p-I	H	H	Me	CH
651	o-O-n-Pr	H	H	Me	CH
652	m-O-n-Pr	H	H	Me	CH
653	p-O-n-Pr	H	H	Me	CH
654	o-O-i-Pr	H	H	Me	CH
655	m-O-i-Pr	H	H	Me	CH
656	p-O-i-Pr	H	H	Me	CH
657	o-O-n-Bu	H	H	Me	CH
658	m-O-n-Bu	H	H	Me	CH
659	p-O-n-Bu	H	H	Me	CH
660	o-O-i-Bu	H	H	Me	CH
661	m-O-i-Bu	H	H	Me	CH
662	p-O-i-Bu	H	H	Me	CH
663	o-OCF3	H	H	Me	CH
664	m-OCF3	H	H	Me	CH
665	p-OCF3	H	H	Me	CH
666	H	H	H	Me	N
667	o-OCH3	H	H	Me	N
668	m-OCH3	H	H	Me	N
669	p-OCH3	H	H	Me	N
670	o-Cl	H	H	Me	N
671	m-Cl	H	H	Me	N
672	p-Cl	H	H	Me	N
673	o-Br	H	H	Me	N
674	m-Br	H	H	Me	N
675	p-Br	H	H	Me	N
676	o-NH2	H	H	Me	N
677	m-NH2	H	H	Me	N
678	p-NH2	H	H	Me	N
679	o-NO2	H	H	Me	N
680	m-NO2	H	H	Me	N
681	p-NO2	H	H	Me	N
682	o-OC2H5	H	H	Me	N
683	m-OC2H5	H	H	Me	N
684	p-OC2H5	H	H	Me	N
685	p-I	H	H	Me	N
686	o-O-n-Pr	H	H	Me	N
687	m-O-n-Pr	H	H	Me	N
688	p-O-n-Pr	H	H	Me	N
689	o-O-i-Pr	H	H	Me	N
690	m-O-i-Pr	H	H	Me	N
691	p-O-i-Pr	H	H	Me	N
692	o-O-n-Bu	H	H	Me	N
693	m-O-n-Bu	H	H	Me	N
694	p-O-n-Bu	H	H	Me	N
695	o-O-i-Bu	H	H	Me	N
696	m-O-i-Bu	H	H	Me	N
697	p-O-i-Bu	H	H	Me	N
698	o-OCF3	H	H	Me	N
699	m-OCF3	H	H	Me	N
700	p-OCF3	H	H	Me	N
701	H	CF3CH2	CF3CH2	CH2F	CH
702	o-OCH3	CF3CH2	CF3CH2	CH2F	CH
703	m-OCH3	CF3CH2	CF3CH2	CH2F	CH
704	p-OCH3	CF3CH2	CF3CH2	CH2F	CH
705	o-Cl	CF3CH2	CF3CH2	CH2F	CH
706	m-Cl	CF3CH2	CF3CH2	CH2F	CH
707	p-Cl	CF3CH2	CF3CH2	CH2F	CH
708	o-Br	CF3CH2	CF3CH2	CH2F	CH
709	m-Br	CF3CH2	CF3CH2	CH2F	CH
710	p-Br	CF3CH2	CF3CH2	CH2F	CH
711	o-NH2	CF3CH2	CF3CH2	CH2F	CH
712	m-NH2	CF3CH2	CF3CH2	CH2F	CH
713	p-NH2	CF3CH2	CF3CH2	CH2F	CH
714	o-NO2	CF3CH2	CF3CH2	CH2F	CH
715	m-NO2	CF3CH2	CF3CH2	CH2F	CH
716	p-NO2	CF3CH2	CF3CH2	CH2F	CH
717	o-OC2H5	CF3CH2	CF3CH2	CH2F	CH
718	m-OC2H5	CF3CH2	CF3CH2	CH2F	CH
719	p-OC2H5	CF3CH2	CF3CH2	CH2F	CH
720	p-I	CF3CH2	CF3CH2	CH2F	CH
721	o-O-n-Pr	CF3CH2	CF3CH2	CH2F	CH
722	m-O-n-Pr	CF3CH2	CF3CH2	CH2F	CH
723	p-O-n-Pr	CF3CH2	CF3CH2	CH2F	CH
724	o-O-i-Pr	CF3CH2	CF3CH2	CH2F	CH
725	m-O-i-Pr	CF3CH2	CF3CH2	CH2F	CH
726	p-O-i-Pr	CF3CH2	CF3CH2	CH2F	CH
727	o-O-n-Bu	CF3CH2	CF3CH2	CH2F	CH
728	m-O-n-Bu	CF3CH2	CF3CH2	CH2F	CH
729	p-O-n-Bu	CF3CH2	CF3CH2	CH2F	CH
730	o-O-i-Bu	CF3CH2	CF3CH2	CH2F	CH
731	m-O-i-Bu	CF3CH2	CF3CH2	CH2F	CH
732	p-O-i-Bu	CF3CH2	CF3CH2	CH2F	CH
733	o-OCF3	CF3CH2	CF3CH2	CH2F	CH
734	m-OCF3	CF3CH2	CF3CH2	CH2F	CH
735	p-OCF3	CF3CH2	CF3CH2	CH2F	CH
736	H	CF3CH2	CF3CH2	CH2F	N
737	o-OCH3	CF3CH2	CF3CH2	CH2F	N
738	m-OCH3	CF3CH2	CF3CH2	CH2F	N
739	p-OCH3	CF3CH2	CF3CH2	CH2F	N
740	o-Cl	CF3CH2	CF3CH2	CH2F	N
741	m-Cl	CF3CH2	CF3CH2	CH2F	N
742	p-Cl	CF3CH2	CF3CH2	CH2F	N
743	o-Br	CF3CH2	CF3CH2	CH2F	N
744	m-Br	CF3CH2	CF3CH2	CH2F	N
745	p-Br	CF3CH2	CF3CH2	CH2F	N
746	o-NH2	CF3CH2	CF3CH2	CH2F	N
747	m-NH2	CF3CH2	CF3CH2	CH2F	N
748	p-NH2	CF3CH2	CF3CH2	CH2F	N
749	o-NO2	CF3CH2	CF3CH2	CH2F	N
750	m-NO2	CF3CH2	CF3CH2	CH2F	N
751	p-NO2	CF3CH2	CF3CH2	CH2F	N
752	o-OC2H5	CF3CH2	CF3CH2	CH2F	N
753	m-OC2H5	CF3CH2	CF3CH2	CH2F	N
754	p-OC2H5	CF3CH2	CF3CH2	CH2F	N
755	p-I	CF3CH2	CF3CH2	CH2F	N
756	o-O-n-Pr	CF3CH2	CF3CH2	CH2F	N
757	m-O-n-Pr	CF3CH2	CF3CH2	CH2F	N
758	p-O-n-Pr	CF3CH2	CF3CH2	CH2F	N
759	o-O-i-Pr	CF3CH2	CF3CH2	CH2F	N
760	m-O-i-Pr	CF3CH2	CF3CH2	CH2F	N
761	p-O-i-Pr	CF3CH2	CF3CH2	CH2F	N
762	o-O-n-Bu	CF3CH2	CF3CH2	CH2F	N
763	m-O-n-Bu	CF3CH2	CF3CH2	CH2F	N
764	p-O-n-Bu	CF3CH2	CF3CH2	CH2F	N
765	o-O-i-Bu	CF3CH2	CF3CH2	CH2F	N
766	m-O-i-Bu	CF3CH2	CF3CH2	CH2F	N
767	p-O-i-Bu	CF3CH2	CF3CH2	CH2F	N
768	o-OCF3	CF3CH2	CF3CH2	CH2F	N
769	m-OCF3	CF3CH2	CF3CH2	CH2F	N
770	p-OCF3	CF3CH2	CF3CH2	CH2F	N
771	H	CF3CH2	Me	CH2F	CH
772	o-OCH3	CF3CH2	Me	CH2F	CH
773	m-OCH3	CF3CH2	Me	CH2F	CH
774	p-OCH3	CF3CH2	Me	CH2F	CH
775	o-Cl	CF3CH2	Me	CH2F	CH
776	m-Cl	CF3CH2	Me	CH2F	CH
777	p-Cl	CF3CH2	Me	CH2F	CH
778	o-Br	CF3CH2	Me	CH2F	CH
779	m-Br	CF3CH2	Me	CH2F	CH
780	p-Br	CF3CH2	Me	CH2F	CH
781	o-NH2	CF3CH2	Me	CH2F	CH
782	m-NH2	CF3CH2	Me	CH2F	CH
783	p-NH2	CF3CH2	Me	CH2F	CH
784	o-NO2	CF3CH2	Me	CH2F	CH
785	m-NO2	CF3CH2	Me	CH2F	CH
786	p-NO2	CF3CH2	Me	CH2F	CH
787	o-OC2H5	CF3CH2	Me	CH2F	CH
788	m-OC2H5	CF3CH2	Me	CH2F	CH
789	p-OC2H5	CF3CH2	Me	CH2F	CH
790	p-I	CF3CH2	Me	CH2F	CH
791	o-O-n-Pr	CF3CH2	Me	CH2F	CH
792	m-O-n-Pr	CF3CH2	Me	CH2F	CH
793	p-O-n-Pr	CF3CH2	Me	CH2F	CH
794	o-O-i-Pr	CF3CH2	Me	CH2F	CH
795	m-O-i-Pr	CF3CH2	Me	CH2F	CH
796	p-O-i-Pr	CF3CH2	Me	CH2F	CH
797	o-O-n-Bu	CF3CH2	Me	CH2F	CH
798	m-O-n-Bu	CF3CH2	Me	CH2F	CH
799	p-O-n-Bu	CF3CH2	Me	CH2F	CH
800	o-O-i-Bu	CF3CH2	Me	CH2F	CH
801	m-O-i-Bu	CF3CH2	Me	CH2F	CH
802	p-O-i-Bu	CF3CH2	Me	CH2F	CH
803	o-OCF3	CF3CH2	Me	CH2F	CH
804	m-OCF3	CF3CH2	Me	CH2F	CH
805	p-OCF3	CF3CH2	Me	CH2F	CH
806	H	CF3CH2	Me	CH2F	N
807	o-OCH3	CF3CH2	Me	CH2F	N
808	m-OCH3	CF3CH2	Me	CH2F	N
809	p-OCH3	CF3CH2	Me	CH2F	N
810	o-Cl	CF3CH2	Me	CH2F	N
811	m-Cl	CF3CH2	Me	CH2F	N
812	p-Cl	CF3CH2	Me	CH2F	N
813	o-Br	CF3CH2	Me	CH2F	N
814	m-Br	CF3CH2	Me	CH2F	N
815	p-Br	CF3CH2	Me	CH2F	N
816	o-NH2	CF3CH2	Me	CH2F	N
817	m-NH2	CF3CH2	Me	CH2F	N
818	p-NH2	CF3CH2	Me	CH2F	N
819	o-NO2	CF3CH2	Me	CH2F	N
820	m-NO2	CF3CH2	Me	CH2F	N
821	p-NO2	CF3CH2	Me	CH2F	N
822	o-OC2H5	CF3CH2	Me	CH2F	N
823	m-OC2H5	CF3CH2	Me	CH2F	N
824	p-OC2H5	CF3CH2	Me	CH2F	N
825	p-I	CF3CH2	Me	CH2F	N
826	o-O-n-Pr	CF3CH2	Me	CH2F	N
827	m-O-n-Pr	CF3CH2	Me	CH2F	N
828	p-O-n-Pr	CF3CH2	Me	CH2F	N
829	o-O-i-Pr	CF3CH2	Me	CH2F	N
830	m-O-i-Pr	CF3CH2	Me	CH2F	N
831	p-O-i-Pr	CF3CH2	Me	CH2F	N
832	o-O-n-Bu	CF3CH2	Me	CH2F	N
833	m-O-n-Bu	CF3CH2	Me	CH2F	N
834	p-O-n-Bu	CF3CH2	Me	CH2F	N
835	o-O-i-Bu	CF3CH2	Me	CH2F	N
836	m-O-i-Bu	CF3CH2	Me	CH2F	N
837	p-O-i-Bu	CF3CH2	Me	CH2F	N
838	o-OCF3	CF3CH2	Me	CH2F	N
839	m-OCF3	CF3CH2	Me	CH2F	N
840	p-OCF3	CF3CH2	Me	CH2F	N
841	H	CF3CH2	Et	CH2F	CH
842	o-OCH3	CF3CH2	Et	CH2F	CH
843	m-OCH3	CF3CH2	Et	CH2F	CH
844	p-OCH3	CF3CH2	Et	CH2F	CH
845	o-Cl	CF3CH2	Et	CH2F	CH
846	m-Cl	CF3CH2	Et	CH2F	CH
847	p-Cl	CF3CH2	Et	CH2F	CH
848	o-Br	CF3CH2	Et	CH2F	CH
849	m-Br	CF3CH2	Et	CH2F	CH
850	p-Br	CF3CH2	Et	CH2F	CH
851	o-NH2	CF3CH2	Et	CH2F	CH
852	m-NH2	CF3CH2	Et	CH2F	CH
853	p-NH2	CF3CH2	Et	CH2F	CH
854	o-NO2	CF3CH2	Et	CH2F	CH
855	m-NO2	CF3CH2	Et	CH2F	CH
856	p-NO2	CF3CH2	Et	CH2F	CH
857	o-OC2H5	CF3CH2	Et	CH2F	CH
858	m-OC2H5	CF3CH2	Et	CH2F	CH
859	p-OC2H5	CF3CH2	Et	CH2F	CH
860	p-I	CF3CH2	Et	CH2F	CH
861	o-O-n-Pr	CF3CH2	Et	CH2F	CH
862	m-O-n-Pr	CF3CH2	Et	CH2F	CH
863	p-O-n-Pr	CF3CH2	Et	CH2F	CH
864	o-O-i-Pr	CF3CH2	Et	CH2F	CH
865	m-O-i-Pr	CF3CH2	Et	CH2F	CH
866	p-O-i-Pr	CF3CH2	Et	CH2F	CH
867	o-O-n-Bu	CF3CH2	Et	CH2F	CH
868	m-O-n-Bu	CF3CH2	Et	CH2F	CH
869	p-O-n-Bu	CF3CH2	Et	CH2F	CH
870	o-O-i-Bu	CF3CH2	Et	CH2F	CH
871	m-O-i-Bu	CF3CH2	Et	CH2F	CH
872	p-O-i-Bu	CF3CH2	Et	CH2F	CH
873	o-OCF3	CF3CH2	Et	CH2F	CH
874	m-OCF3	CF3CH2	Et	CH2F	CH
875	p-OCF3	CF3CH2	Et	CH2F	CH
876	H	CF3CH2	Et	CH2F	N
877	o-OCH3	CF3CH2	Et	CH2F	N
878	m-OCH3	CF3CH2	Et	CH2F	N
879	p-OCH3	CF3CH2	Et	CH2F	N
880	o-Cl	CF3CH2	Et	CH2F	N
881	m-Cl	CF3CH2	Et	CH2F	N
882	p-Cl	CF3CH2	Et	CH2F	N
883	o-Br	CF3CH2	Et	CH2F	N
884	m-Br	CF3CH2	Et	CH2F	N
885	p-Br	CF3CH2	Et	CH2F	N
886	o-NH2	CF3CH2	Et	CH2F	N
887	m-NH2	CF3CH2	Et	CH2F	N
888	p-NH2	CF3CH2	Et	CH2F	N
889	o-NO2	CF3CH2	Et	CH2F	N
890	m-NO2	CF3CH2	Et	CH2F	N
891	p-NO2	CF3CH2	Et	CH2F	N
892	o-OC2H5	CF3CH2	Et	CH2F	N
893	m-OC2H5	CF3CH2	Et	CH2F	N
894	p-OC2H5	CF3CH2	Et	CH2F	N
895	p-I	CF3CH2	Et	CH2F	N
896	o-O-n-Pr	CF3CH2	Et	CH2F	N
897	m-O-n-Pr	CF3CH2	Et	CH2F	N
898	p-O-n-Pr	CF3CH2	Et	CH2F	N
899	o-O-i-Pr	CF3CH2	Et	CH2F	N
900	m-O-i-Pr	CF3CH2	Et	CH2F	N
901	p-O-i-Pr	CF3CH2	Et	CH2F	N
902	o-O-n-Bu	CF3CH2	Et	CH2F	N
903	m-O-n-Bu	CF3CH2	Et	CH2F	N
904	p-O-n-Bu	CF3CH2	Et	CH2F	N
905	o-O-i-Bu	CF3CH2	Et	CH2F	N
906	m-O-i-Bu	CF3CH2	Et	CH2F	N
907	p-O-i-Bu	CF3CH2	Et	CH2F	N
908	o-OCF3	CF3CH2	Et	CH2F	N
909	m-OCF3	CF3CH2	Et	CH2F	N
910	p-OCF3	CF3CH2	Et	CH2F	N
911	H	CF3CH2	H	CH2F	CH
912	o-OCH3	CF3CH2	H	CH2F	CH
913	m-OCH3	CF3CH2	H	CH2F	CH
914	p-OCH3	CF3CH2	H	CH2F	CH
915	o-Cl	CF3CH2	H	CH2F	CH
916	m-Cl	CF3CH2	H	CH2F	CH
917	p-Cl	CF3CH2	H	CH2F	CH
918	o-Br	CF3CH2	H	CH2F	CH
919	m-Br	CF3CH2	H	CH2F	CH
920	p-Br	CF3CH2	H	CH2F	CH
921	o-NH2	CF3CH2	H	CH2F	CH
922	m-NH2	CF3CH2	H	CH2F	CH
923	p-NH2	CF3CH2	H	CH2F	CH
924	o-NO2	CF3CH2	H	CH2F	CH
925	m-NO2	CF3CH2	H	CH2F	CH
926	p-NO2	CF3CH2	H	CH2F	CH
927	o-OC2H5	CF3CH2	H	CH2F	CH
928	m-OC2H5	CF3CH2	H	CH2F	CH
929	p-OC2H5	CF3CH2	H	CH2F	CH
930	p-I	CF3CH2	H	CH2F	CH
931	o-O-n-Pr	CF3CH2	H	CH2F	CH
932	m-O-n-Pr	CF3CH2	H	CH2F	CH
933	p-O-n-Pr	CF3CH2	H	CH2F	CH
934	o-O-i-Pr	CF3CH2	H	CH2F	CH
935	m-O-i-Pr	CF3CH2	H	CH2F	CH
936	p-O-i-Pr	CF3CH2	H	CH2F	CH
937	o-O-n-Bu	CF3CH2	H	CH2F	CH
938	m-O-n-Bu	CF3CH2	H	CH2F	CH
939	p-O-n-Bu	CF3CH2	H	CH2F	CH
940	o-O-i-Bu	CF3CH2	H	CH2F	CH
941	m-O-i-Bu	CF3CH2	H	CH2F	CH
942	p-O-i-Bu	CF3CH2	H	CH2F	CH
943	o-OCF3	CF3CH2	H	CH2F	CH
944	m-OCF3	CF3CH2	H	CH2F	CH
945	p-OCF3	CF3CH2	H	CH2F	CH
946	H	CF3CH2	H	CH2F	N
947	o-OCH3	CF3CH2	H	CH2F	N
948	m-OCH3	CF3CH2	H	CH2F	N
949	p-OCH3	CF3CH2	H	CH2F	N
950	o-Cl	CF3CH2	H	CH2F	N
951	m-Cl	CF3CH2	H	CH2F	N
952	p-Cl	CF3CH2	H	CH2F	N
953	o-Br	CF3CH2	H	CH2F	N
954	m-Br	CF3CH2	H	CH2F	N
955	p-Br	CF3CH2	H	CH2F	N
956	o-NH2	CF3CH2	H	CH2F	N
957	m-NH2	CF3CH2	H	CH2F	N
958	p-NH2	CF3CH2	H	CH2F	N
959	o-NO2	CF3CH2	H	CH2F	N
960	m-NO2	CF3CH2	H	CH2F	N
961	p-NO2	CF3CH2	H	CH2F	N
962	o-OC2H5	CF3CH2	H	CH2F	N
963	m-OC2H5	CF3CH2	H	CH2F	N
964	p-OC2H5	CF3CH2	H	CH2F	N
965	p-I	CF3CH2	H	CH2F	N
966	o-O-n-Pr	CF3CH2	H	CH2F	N
967	m-O-n-Pr	CF3CH2	H	CH2F	N
968	p-O-n-Pr	CF3CH2	H	CH2F	N
969	o-O-i-Pr	CF3OH2-	H	CH2F	N
970	m-O-i-Pr	CF3CH2	H	CH2F	N
971	p-O-i-Pr	CF3CH2	H	CH2F	N
972	o-O-n-Bu	CF3CH2	H	CH2F	N
973	m-O-n-Bu	CF3CH2	H	CH2F	N
974	p-O-n-Bu	CF3CH2	H	CH2F	N
975	o-O-i-Bu	CF3CH2	H	CH2F	N
976	m-O-i-Bu	CF3CH2	H	CH2F	N
977	p-O-i-Bu	CF3CH2	H	CH2F	N
978	o-OCF3	CF3CH2	H	CH2F	N
979	m-OCF3	CF3CH2	H	CH2F	N
980	p-OCF3	CF3CH2	H	CH2F	N
981	H	H	H	CH2F	CH
982	o-OCH3	H	H	CH2F	CH
983	m-OCH3	H	H	CH2F	CH
984	p-OCH3	H	H	CH2F	CH
985	o-Cl	H	H	CH2F	CH
986	m-Cl	H	H	CH2F	CH
987	p-Cl	H	H	CH2F	CH
988	o-Br	H	H	CH2F	CH
989	m-Br	H	H	CH2F	CH
990	p-Br	H	H	CH2F	CH
991	o-NH2	H	H	CH2F	CH
992	m-NH2	H	H	CH2F	CH
993	p-NH2	H	H	CH2F	CH
994	o-NO2	H	H	CH2F	CH
995	m-NO2	H	H	CH2F	CH
996	p-NO2	H	H	CH2F	CH
997	o-OC2H5	H	H	CH2F	CH
998	m-OC2H5	H	H	CH2F	CH
999	p-OC2H5	H	H	CH2F	CH
1000	p-I	H	H	CH2F	CH
1001	o-O-n-Pr	H	H	CH2F	CH
1002	m-O-n-Pr	H	H	CH2F	CH
1003	p-O-n-Pr	H	H	CH2F	CH
1004	o-O-i-Pr	H	H	CH2F	CH
1005	m-O-i-Pr	H	H	CH2F	CH
1006	p-O-i-Pr	H	H	CH2F	CH
1007	o-O-n-Bu	H	H	CH2F	CH
1008	m-O-n-Bu	H	H	CH2F	CH
1009	p-O-n-Bu	H	H	CH2F	CH
1010	o-O-i-Bu	H	H	CH2F	CH
1011	m-O-i-Bu	H	H	CH2F	CH
1012	p-O-i-Bu	H	H	CH2F	CH
1013	o-OCF3	H	H	CH2F	CH
1014	m-OCF3	H	H	CH2F	CH
1015	p-OCF3	H	H	CH2F	CH
1016	H	H	H	CH2F	N
1017	o-OCH3	H	H	CH2F	N
1018	m-OCH3	H	H	CH2F	N
1019	p-OCH3	H	H	CH2F	N
1020	o-Cl	H	H	CH2F	N
1021	m-Cl	H	H	CH2F	N
1022	p-Cl	H	H	CH2F	N
1023	o-Br	H	H	CH2F	N
1024	m-Br	H	H	CH2F	N
1025	p-Br	H	H	CH2F	N
1026	o-NH2	H	H	CH2F	N
1027	m-NH2	H	H	CH2F	N
1028	p-NH2	H	H	CH2F	N
1029	o-NO2	H	H	CH2F	N
1030	m-NO2	H	H	CH2F	N
1031	p-NO2	H	H	CH2F	N
1032	o-OC2H5	H	H	CH2F	N
1033	m-OC2H5	H	H	CH2F	N
1034	p-OC2H5	H	H	CH2F	N
1035	p-I	H	H	CH2F	N
1036	o-O-n-Pr	H	H	CH2F	N
1037	m-O-n-Pr	H	H	CH2F	N
1038	p-O-n-Pr	H	H	CH2F	N
1039	o-O-i-Pr	H	H	CH2F	N
1040	m-O-i-Pr	H	H	CH2F	N
1041	p-O-i-Pr	H	H	CH2F	N
1042	o-O-n-Bu	H	H	CH2F	N
1043	m-O-n-Bu	H	H	CH2F	N
1044	p-O-n-Bu	H	H	CH2F	N
1045	o-O-i-Bu	H	H	CH2F	N
1046	m-O-i-Bu	H	H	CH2F	N
1047	p-O-i-Bu	H	H	CH2F	N
1048	o-OCF3	H	H	CH2F	N
1049	m-OCF3	H	H	CH2F	N
1050	pOCF3	H	H	CH2F	N
1051	H	CF3CH2	CF3CH2	CH2OH	CH
1052	o-OCH3	CF3CH2	CF3CH2	CH2OH	CH
1053	m-OCH3	CF3CH2	CF3CH2	CH2OH	CH
1054	p-OCH3	CF3CH2	CF3CH2	CH2OH	CH
1055	o-Cl	CF3CH2	CF3CH2	CH2OH	CH
1056	m-Cl	CF3CH2	CF3CH2	CH2OH	CH
1057	p-Cl	CF3CH2	CF3CH2	CH2OH	CH
1058	o-Br	CF3CH2	CF3CH2	CH2OH	CH
1059	m-Br	CF3CH2	CF3CH2	CH2OH	CH
1060	p-Br	CF3CH2	CF3CH2	CH2OH	CH
1061	o-NH2	CF3CH2	CF3CH2	CH2OH	CH
1062	m-NH2	CF3CH2	CF3CH2	CH2OH	CH
1063	p-NH2	CF3CH2	CF3CH2	CH2OH	CH
1064	o-NO2	CF3CH2	CF3CH2	CH2OH	CH
1065	m-NO2	CF3CH2	CF3CH2	CH2OH	CH
1066	p-NO2	CF3CH2	CF3CH2	CH2OH	CH
1067	o-OC2H5	CF3CH2	CF3CH2	CH2OH	CH
1068	m-OC2H5	CF3CH2	CF3CH2	CH2OH	CH
1069	p-OC2H5	CF3CH2	CF3CH2	CH2OH	CH
1070	p-I	CF3CH2	CF3CH2	CH2OH	CH
1071	o-O-n-Pr	CF3CH2	CF3CH2	CH2OH	CH
1072	m-O-n-Pr	CF3CH2	CF3CH2	CH2OH	CH
1073	p-O-n-Pr	CF3CH2	CF3CH2	CH2OH	CH
1074	o-O-i-Pr	CF3CH2	CF3CH2	CH2OH	CH
1075	m-O-i-Pr	CF3CH2	CF3CH2	CH2OH	CH
1076	p-O-i-Pr	CF3CH2	CF3CH2	CH2OH	CH
1077	o-O-n-Bu	CF3CH2	CF3CH2	CH2OH	CH
1078	m-O-n-Bu	CF3CH2	CF3CH2	CH2OH	CH
1079	p-O-n-Bu	CF3CH2	CF3CH2	CH2OH	CH
1080	o-O-i-Bu	CF3CH2	CF3CH2	CH2OH	CH
1081	m-O-i-Bu	CF3CH2	CF3CH2	CH2OH	CH
1082	p-O-i-Bu	CF3CH2	CF3CH2	CH2OH	CH
1083	o-OCF3	CF3CH2	CF3CH2	CH2OH	CH
1084	m-OCF3	CF3CH2	CF3CH2	CH2OH	CH
1085	p-OCF3	CF3CH2	CF3CH2	CH2OH	CH
1086	H	CF3CH2	CF3CH2	CH2OH	N
1087	o-OCH3	CF3CH2	CF3CH2	CH2OH	N
1088	m-OCH3	CF3CH2	CF3CH2	CH2OH	N
1089	p-OCH3	CF3CH2	CF3CH2	CH2OH	N
1090	o-Cl	CF3CH2	CF3CH2	CH2OH	N
1091	m-Cl	CF3CH2	CF3CH2	CH2OH	N
1092	p-Cl	CF3CH2	CF3CH2	CH2OH	N
1093	o-Br	CF3CH2	CF3CH2	CH2OH	N
1094	m-Br	CF3CH2	CF3CH2	CH2OH	N
1095	p-Br	CF3CH2	CF3CH2	CH2OH	N
1096	o-NH2	CF3CH2	CF3CH2	CH2OH	N
1097	m-NH2	CF3CH2	CF3CH2	CH2OH	N
1098	p-NH2	CF3CH2	CF3CH2	CH2OH	N
1099	o-NO2	CF3CH2	CF3CH2	CH2OH	N
1100	m-NO2	CF3CH2	CF3CH2	CH2OH	N
1101	p-NO2	CF3CH2	CF3CH2	CH2OH	N
1102	o-OC2H5	CF3CH2	CF3CH2	CH2OH	N
1103	m-OC2H5	CF3CH2	CF3CH2	CH2OH	N
1104	p-OC2H5	CF3CH2	CF3CH2	CH2OH	N
1105	p-I	CF3CH2	CF3CH2	CH2OH	N
1106	o-O-n-Pr	CF3CH2	CF3CH2	CH2OH	N
1107	m-O-n-Pr	CF3CH2	CF3CH2	CH2OH	N
1108	p-O-n-Pr	CF3CH2	CF3CH2	CH2OH	N
1109	o-O-i-Pr	CF3CH2	CF3CH2	CH2OH	N
1110	m-O-i-Pr	CF3CH2	CF3CH2	CH2OH	N
1111	p-O-i-Pr	CF3CH2	CF3CH2	CH2OH	N
1112	o-O-n-Bu	CF3CH2	CF3CH2	CH2OH	N
1113	m-O-n-Bu	CF3CH2	CF3CH2	CH2OH	N
1114	p-O-n-Bu	CF3CH2	CF3CH2	CH2OH	N
1115	o-O-i-Bu	CF3CH2	CF3CH2	CH2OH	N
1116	m-O-i-Bu	CF3CH2	CF3CH2	CH2OH	N
1117	p-O-i-Bu	CF3CH2	CF3CH2	CH2OH	N
1118	o-OCF3	CF3CH2	CF3CH2	CH2OH	N
1119	m-OCF3	CF3CH2	CF3CH2	CH2OH	N
1120	p-OCF3	CF3CH2	CF3CH2	CH2OH	N
1121	H	CF3CH2	Me	CH2OH	CH
1122	o-OCH3	CF3CH2	Me	CH2OH	CH
1123	m-OCH3	CF3CH2	Me	CH2OH	CH
1124	p-OCH3	CF3CH2	Me	CH2OH	CH
1125	o-Cl	CF3CH2	Me	CH2OH	CH
1126	m-Cl	CF3CH2	Me	CH2OH	CH
1127	p-Cl	CF3CH2	Me	CH2OH	CH
1128	o-Br	CF3CH2	Me	CH2OH	CH
1129	m-Br	CF3CH2	Me	CH2OH	CH
1130	p-Br	CF3CH2	Me	CH2OH	CH
1131	o-NH2	CF3CH2	Me	CH2OH	CH
1132	m-NH2	CF3CH2	Me	CH2OH	CH
1133	p-NH2	CF3CH2	Me	CH2OH	CH
1134	o-NO2	CF3CH2	Me	CH2OH	CH
1135	m-NO2	CF3CH2	Me	CH2OH	CH
1136	p-NO2	CF3CH2	Me	CH2OH	CH
1137	o-OC2H5	CF3CH2	Me	CH2OH	CH
1138	m-OC2H5	CF3CH2	Me	CH2OH	CH
1139	p-OC2H5	CF3CH2	Me	CH2OH	CH
1140	p-I	CF3CH2	Me	CH2OH	CH
1141	o-O-n-Pr	CF3CH2	Me	CH2OH	CH
1142	m-O-n-Pr	CF3CH2	Me	CH2OH	CH
1143	p-O-n-Pr	CF3CH2	Me	CH2OH	CH
1144	o-O-i-Pr	CF3CH2	Me	CH2OH	CH
1145	m-O-i-Pr	CF3CH2	Me	CH2OH	CH
1146	p-O-i-Pr	CF3CH2	Me	CH2OH	CH
1147	o-O-n-Bu	CF3CH2	Me	CH2OH	CH
1148	m-O-n-Bu	CF3CH2	Me	CH2OH	CH
1149	p-O-n-Bu	CF3CH2	Me	CH2OH	CH
1150	o-O-i-Bu	CF3CH2	Me	CH2OH	CH
1151	m-O-i-Bu	CF3CH2	Me	CH2OH	CH
1152	p-O-i-Bu	CF3CH2	Me	CH2OH	CH
1153	o-OCF3	CF3CH2	Me	CH2OH	CH
1154	m-OCF3	CF3CH2	Me	CH2OH	CH
1155	p-OCF3	CF3CH2	Me	CH2OH	CH
1156	H	CF3CH2	Me	CH2OH	N
1157	o-OCH3	CF3CH2	Me	CH2OH	N
1158	m-OCH3	CF3CH2	Me	CH2OH	N
1159	p-OCH3	CF3CH2	Me	CH2OH	N
1160	o-Cl	CF3CH2	Me	CH2OH	N
1161	m-Cl	CF3CH2	Me	CH2OH	N
1162	p-Cl	CF3CH2	Me	CH2OH	N
1163	o-Br	CF3CH2	Me	CH2OH	N
1164	m-Br	CF3CH2	Me	CH2OH	N
1165	p-Br	CF3CH2	Me	CH2OH	N
1166	o-NH2	CF3CH2	Me	CH2OH	N
1167	m-NH2	CF3CH2	Me	CH2OH	N
1168	p-NH2	CF3CH2	Me	CH2OH	N
1169	o-NO2	CF3CH2	Me	CH2OH	N
1170	m-NO2	CF3CH2	Me	CH2OH	N
1171	p-NO2	CF3CH2	Me	CH2OH	N
1172	o-OC2H5	CF3CH2	Me	CH2OH	N
1173	m-OC2H5	CF3CH2	Me	CH2OH	N
1174	p-OC2H5	CF3CH2	Me	CH2OH	N
1175	p-I	CF3CH2	Me	CH2OH	N
1176	o-O-n-Pr	CF3CH2	Me	CH2OH	N
1177	m-O-n-Pr	CF3CH2	Me	CH2OH	N
1178	p-O-n-Pr	CF3CH2	Me	CH2OH	N
1179	o-O-i-Pr	CF3CH2	Me	CH2OH	N
1180	m-O-i-Pr	CF3CH2	Me	CH2OH	N
1181	p-O-i-Pr	CF3CH2	Me	CH2OH	N
1182	o-O-n-Bu	CF3CH2	Me	CH2OH	N
1183	m-O-n-Bu	CF3CH2	Me	CH2OH	N
1184	p-O-n-Bu	CF3CH2	Me	CH2OH	N
1185	o-O-i-Bu	CF3CH2	Me	CH2OH	N
1186	m-O-i-Bu	CF3CH2	Me	CH2OH	N
1187	p-O-i-Bu	CF3CH2	Me	CH2OH	N
1188	o-OCF3	CF3CH2	Me	CH2OH	N
1189	m-OCF3	CF3CH2	Me	CH2OH	N
1190	p-OCF3	CF3CH2	Me	CH2OH	N
1191	H	CF3CH2	Et	CH2OH	CH
1192	o-OCH3	CF3CH2	Et	CH2OH	CH
1193	m-OCH3	CF3CH2	Et	CH2OH	CH
1194	p-OCH3	CF3CH2	Et	CH2OH	CH
1195	o-Cl	CF3CH2	Et	CH2OH	CH
1196	m-Cl	CF3CH2	Et	CH2OH	CH
1197	p-Cl	CF3CH2	Et	CH2OH	CH
1198	o-Br	CF3CH2	Et	CH2OH	CH
1199	m-Br	CF3CH2	Et	CH2OH	CH
1200	p-Br	CF3CH2	Et	CH2OH	CH
1201	o-NH2	CF3CH2	Et	CH2OH	CH
1202	m-NH2	CF3CH2	Et	CH2OH	CH
1203	p-NH2	CF3CH2	Et	CH2OH	CH
1204	o-NO2	CF3CH2	Et	CH2OH	CH
1205	m-NO2	CF3CH2	Et	CH2OH	CH
1206	p-NO2	CF3CH2	Et	CH2OH	CH
1207	o-OC2H5	CF3CH2	Et	CH2OH	CH
1208	m-OC2H5	CF3CH2	Et	CH2OH	CH
1209	p-OC2H5	CF3CH2	Et	CH2OH	CH
1210	p-I	CF3CH2	Et	CH2OH	CH
1211	o-O-n-Pr	CF3CH2	Et	CH2OH	CH
1212	m-O-n-Pr	CF3CH2	Et	CH2OH	CH
1213	p-O-n-Pr	CF3CH2	Et	CH2OH	CH
1214	o-O-i-Pr	CF3CH2	Et	CH2OH	CH
1215	m-O-i-Pr	CF3CH2	Et	CH2OH	CH
1216	p-O-i-Pr	CF3CH2	Et	CH2OH	CH
1217	o-O-n-Bu	CF3CH2	Et	CH2OH	CH
1218	m-O-n-Bu	CF3CH2	Et	CH2OH	CH
1219	p-O-n-Bu	CF3CH2	Et	CH2OH	CH
1220	o-O-i-Bu	CF3CH2	Et	CH2OH	CH
1221	m-O-i-Bu	CF3CH2	Et	CH2OH	CH
1222	p-O-i-Bu	CF3CH2	Et	CH2OH	CH
1223	o-OCF3	CF3CH2	Et	CH2OH	CH
1224	m-OCF3	CF3CH2	Et	CH2OH	CH
1225	p-OCF3	CF3CH2	Et	CH2OH	CH
1226	H	CF3CH2	Et	CH2OH	N
1227	o-OCH3	CF3CH2	Et	CH2OH	N
1228	m-OCH3	CF3CH2	Et	CH2OH	N
1229	p-OCH3	CF3CH2	Et	CH2OH	N
1230	o-Cl	CF3CH2	Et	CH2OH	N
1231	m-Cl	CF3CH2	Et	CH2OH	N
1232	p-Cl	CF3CH2	Et	CH2OH	N
1233	o-Br	CF3CH2	Et	CH2OH	N
1234	m-Br	CF3CH2	Et	CH2OH	N
1235	p-Br	CF3CH2	Et	CH2OH	N
1236	o-NH2	CF3CH2	Et	CH2OH	N
1237	m-NH2	CF3CH2	Et	CH2OH	N
1238	p-NH2	CF3CH2	Et	CH2OH	N
1239	o-NO2	CF3CH2	Et	CH2OH	N
1240	m-NO2	CF3CH2	Et	CH2OH	N
1241	p-NO2	CF3CH2	Et	CH2OH	N
1242	o-OC2H5	CF3CH2	Et	CH2OH	N
1243	m-OC2H5	CF3CH2	Et	CH2OH	N
1244	p-OC2H5	CF3CH2	Et	CH2OH	N
1245	p-I	CF3CH2	Et	CH2OH	N
1246	o-O-n-Pr	CF3CH2	Et	CH2OH	N
1247	m-O-n-Pr	CF3CH2	Et	CH2OH	N
1248	p-O-n-Pr	CF3CH2	Et	CH2OH	N
1249	o-O-i-Pr	CF3CH2	Et	CH2OH	N
1250	m-O-i-Pr	CF3CH2	Et	CH2OH	N
1251	p-O-i-Pr	CF3CH2	Et	CH2OH	N
1252	o-O-n-Bu	CF3CH2	Et	CH2OH	N
1253	m-O-n-Bu	CF3CH2	Et	CH2OH	N
1254	p-O-n-Bu	CF3CH2	Et	CH2OH	N
1255	o-O-i-Bu	CF3CH2	Et	CH2OH	N
1256	m-O-i-Bu	CF3CH2	Et	CH2OH	N
1257	p-O-i-Bu	CF3CH2	Et	CH2OH	N
1258	o-OCF3	CF3CH2	Et	CH2OH	N
1259	m-OCF3	CF3CH2	Et	CH2OH	N
1260	p-OCF3	CF3CH2	Et	CH2OH	N
1261	H	CF3CH2	H	CH2OH	CH
1262	o-OCH3	CF3CH2	H	CH2OH	CH
1263	m-OCH3	CF3CH2	H	CH2OH	CH
1264	p-OCH3	CF3CH2	H	CH2OH	CH
1265	o-Cl	CF3CH2	H	CH2OH	CH
1266	m-Cl	CF3CH2	H	CH2OH	CH
1267	p-Cl	CF3CH2	H	CH2OH	CH
1268	o-Br	CF3CH2	H	CH2OH	CH
1269	m-Br	CF3CH2	H	CH2OH	CH
1270	p-Br	CF3CH2	H	CH2OH	CH
1271	o-NH2	CF3CH2	H	CH2OH	CH
1272	m-NH2	CF3CH2	H	CH2OH	CH
1273	p-NH2	CF3CH2	H	CH2OH	CH
1274	o-NO2	CF3CH2	H	CH2OH	CH
1275	m-NO2	CF3CH2	H	CH2OH	CH
1276	p-NO2	CF3CH2	H	CH2OH	CH
1277	o-OC2H5	CF3CH2	H	CH2OH	CH
1278	m-OC2H5	CF3CH2	H	CH2OH	CH
1279	p-OC2H5	CF3CH2	H	CH2OH	CH
1280	p-I	CF3CH2	H	CH2OH	CH
1281	o-O-n-Pr	CF3CH2	H	CH2OH	CH
1282	m-O-n-Pr	CF3CH2	H	CH2OH	CH
1283	p-O-n-Pr	CF3CH2	H	CH2OH	CH
1284	o-O-i-Pr	CF3CH2	H	CH2OH	CH
1285	m-O-i-Pr	CF3CH2	H	CH2OH	CH
1286	p-O-i-Pr	CF3CH2	H	CH2OH	CH
1287	o-O-n-Bu	CF3CH2	H	CH2OH	CH
1288	m-O-n-Bu	CF3CH2	H	CH2OH	CH
1289	p-O-n-Bu	CF3CH2	H	CH2OH	CH
1290	o-O-i-Bu	CF3CH2	H	CH2OH	CH
1291	m-O-i-Bu	CF3CH2	H	CH2OH	CH
1292	p-O-i-Bu	CF3CH2	H	CH2OH	CH
1293	o-OCF3	CF3CH2	H	CH2OH	CH
1294	m-OCF3	CF3CH2	H	CH2OH	CH
1295	p-OCF3	CF3CH2	H	CH2OH	CH
1296	H	CF3CH2	H	CH2OH	N
1297	o-OCH3	CF3CH2	H	CH2OH	N
1298	m-OCH3	CF3CH2	H	CH2OH	N
1299	p-OCH3	CF3CH2	H	CH2OH	N
1300	o-Cl	CF3CH2	H	CH2OH	N
1301	m-Cl	CF3CH2	H	CH2OH	N
1302	p-Cl	CF3CH2	H	CH2OH	N
1303	o-Br	CF3CH2	H	CH2OH	N
1304	m-Br	CF3CH2	H	CH2OH	N
1305	p-Br	CF3CH2	H	CH2OH	N
1306	o-NH2	CF3CH2	H	CH2OH	N
1307	m-NH2	CF3CH2	H	CH2OH	N
1308	p-NH2	CF3CH2	H	CH2OH	N
1309	o-NO2	CF3CH2	H	CH2OH	N
1310	m-NO2	CF3CH2	H	CH2OH	N
1311	p-NO2	CF3CH2	H	CH2OH	N
1312	o-OC2H5	CF3CH2	H	CH2OH	N
1313	m-OC2H5	CF3CH2	H	CH2OH	N
1314	p-OC2H5	CF3CH2	H	CH2OH	N
1315	p-I	CF3CH2	H	CH2OH	N
1316	o-O-n-Pr	CF3CH2	H	CH2OH	N
1317	m-O-n-Pr	CF3CH2	H	CH2OH	N
1318	p-O-n-Pr	CF3CH2	H	CH2OH	N
1319	o-O-i-Pr	CF3CH2	H	CH2OH	N
1320	m-O-i-Pr	CF3CH2	H	CH2OH	N
1321	p-O-i-Pr	CF3CH2	H	CH2OH	N
1322	o-O-n-Bu	CF3CH2	H	CH2OH	N
1323	m-O-n-Bu	CF3CH2	H	CH2OH	N
1324	p-O-n-Bu	CF3CH2	H	CH2OH	N
1325	o-O-i-Bu	CF3CH2	H	CH2OH	N
1326	m-O-i-Bu	CF3CH2	H	CH2OH	N
1327	p-O-i-Bu	CF3CH2	H	CH2OH	N
1328	o-OCF3	CF3CH2	H	CH2OH	N
1329	m-OCF3	CF3CH2	H	CH2OH	N
1330	p-OCF3	CF3CH2	H	CH2OH	N
1331	H	H	H	CH2OH	CH
1332	o-OCH3	H	H	CH2OH	CH
1333	m-OCH3	H	H	CH2OH	CH
1334	p-OCH3	H	H	CH2OH	CH
1335	o-Cl	H	H	- CH2OH	CH
1336	m-Cl	H	H	- CH2OH	CH
1337	p-Cl	H	H	CH2OH	CH
1338	o-Br	H	H	CH2OH	CH
1339	m-Br	H	H	CH2OH	CH
1340	p-Br	H	H	CH2OH	CH
1341	o-NH2	H	H	CH2OH	CH
1342	m-NH2	H	H	CH2OH	CH
1343	p-NH2	H	H	CH2OH	CH
1344	o-NO2	H	H	CH2OH	CH
1345	m-NO2	H	H	CH2OH	CH
1346	p-NO2	H	H	CH2OH	CH
1347	o-OC2H5	H	H	CH2OH	CH
1348	m-OC2H5	H	H	CH2OH	CH
1349	p-OC2H5	H	H	CH2OH	CH
1350	p-I	H	H	CH2OH	CH
1351	o-O-n-Pr	H	H	CH2OH	CH
1352	m-O-n-Pr	H	H	CH2OH	CH
1353	p-O-n-Pr	H	H	CH2OH	CH
1354	o-O-i-Pr	H	H	CH2OH	CH
1355	m-O-i-Pr	H	H	CH2OH	CH
1356	p-O-i-Pr	H	H	CH2OH	CH
1357	o-O-n-Bu	H	H	CH2OH	CH
1358	m-O-n-Bu	H	H	CH2OH	CH
1359	p-O-n-Bu	H	H	CH2OH	CH
1360	o-O-i-Bu	H	H	CH2OH	CH
1361	m-O-i-Bu	H	H	CH2OH	CH
1362	p-O-i-Bu	H	H	CH2OH	CH
1363	o-OCF3	H	H	CH2OH	CH
1364	m-OCF3	H	H	CH2OH	CH
1365	p-OCF3	H	H	CH2OH	CH
1366	H	H	H	CH2OH	N
1367	o-OCH3	H	H	CH2OH	N
1368	m-OCH3	H	H	CH2OH	N
1369	p-OCH3	H	H	-CH2OH	N
1370	o-Cl	H	H	CH2OH	N
1371	m-Cl	H	H	CH2OH	N
1372	p-Cl	H	H	CH2OH	N
1373	o-Br	H	H	CH2OH	N
1374	m-Br	H	H	CH2OH	N
1375	p-Br	H	H	CH2OH	N
1376	o-NH2	H	H	CH2OH	N
1377	m-NH2	H	H	CH2OH	N
1378	p-NH2	H	H	CH2OH	N
1379	o-NO2	H	H	CH2OH	N
1380	m-NO2	H	H	CH2OH	N
1381	p-NO2	H	H	CH2OH	N
1382	o-OC2H5	H	H	CH2OH	N
1383	m-OC2H5	H	H	CH2OH	N
1384	p-OC2H5	H	H	CH2OH	N
1385	p-I	H	H	CH2OH	N
1386	o-O-n-Pr	H	H	CH2OH	N
1387	m-O-n-Pr	H	H	CH2OH	N
1388	p-O-n-Pr	H	H	CH2OH	N
1389	o-O-i-Pr	H	H	CH2OH	N
1390	m-O-i-Pr	H	H	CH2OH	N
1391	p-O-i-Pr	H	H	CH2OH	N
1392	o-O-n-Bu	H	H	CH2OH	N
1393	m-O-n-Bu	H	H	CH2OH	N
1394	p-O-n-Bu	H	H	CH2OH	N
1395	o-O-i-Bu	H	H	CH2OH	N
1396	m-O-i-Bu	H	H	CH2OH	N
1397	p-O-i-Bu	H	H	CH2OH	N
1398	o-OCF3	H	H	CH2OH	N
1399	m-OCF3	H	H	CH2OH	N
1400	p-OCF3	H	H	CH2OH	N
1401	H	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1402	o-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1403	m-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1404	p-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1405	o-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1406	m-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1407	p-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1408	o-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1409	m-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1410	p-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1411	o-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1412	m-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1413	p-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1414	o-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1415	m-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1416	p-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1417	o-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1418	m-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1419	p-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1420	p-I	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1421	o-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1422	m-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1423	p-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1424	o-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1425	m-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1426	p-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1427	o-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1428	m-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1429	p-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1430	o-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1431	m-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1432	p-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1433	o-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1434	m-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1435	p-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	H	CH
1436	H	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1437	o-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1438	m-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1439	p-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1440	o-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1441	m-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1442	p-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1443	o-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1444	m-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1445	p-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1446	o-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1447	m-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1448	p-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1449	o-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1450	m-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1451	p-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1452	o-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1453	m-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1454	p-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1455	p-I	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1456	o-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1457	m-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1458	p-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1459	o-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1460	m-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1461	p-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1462	o-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1463	m-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1464	p-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1465	o-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1466	m-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1467	p-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1468	o-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1469	m-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1470	p-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	Me	CH
1471	H	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1472	o-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1473	m-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1474	p-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1475	o-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1476	m-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1477	p-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1478	o-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1479	m-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1480	p-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1481	o-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1482	m-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1483	p-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1484	o-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1485	m-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1486	p-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1487	o-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1488	m-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1489	p-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1490	p-I	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1491	o-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1492	m-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1493	p-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1494	o-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1495	m-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1496	p-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1497	o-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1498	m-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1499	p-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1500	o-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1501	m-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1502	p-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1503	o-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1504	m-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1505	p-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2F	CH
1506	H	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1507	o-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1508	m-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1509	p-OCH3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1510	o-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1511	m-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1512	p-Cl	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1513	o-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1514	m-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1515	p-Br	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1516	o-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1517	m-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1518	p-NH2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1519	o-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1520	m-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1521	p-NO2	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1522	o-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1523	m-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1524	p-OC2H5	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1525	p-I	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1526	o-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1527	m-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1528	p-O-n-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1529	o-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1530	m-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1531	p-O-i-Pr	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1532	o-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1533	m-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1534	p-O-n-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1535	o-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1536	m-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1537	p-O-i-Bu	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1538	o-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1539	m-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1540	p-OCF3	CH2O-CO-t-Bu	CH2O-CO-t-Bu	CH2OH	CH
1541	H	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1542	o-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1543	m-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1544	p-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1545	o-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1546	m-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1547	p-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1548	o-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1549	m-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1550	p-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1551	o-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1552	m-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1553	p-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1554	o-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1555	m-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1556	p-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1557	o-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1558	m-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1559	p-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1560	p-I	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1561	o-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1562	m-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1563	p-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1564	o-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1565	m-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1566	p-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1567	o-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1568	m-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1569	p-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1570	o-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1571	m-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1572	p-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1573	o-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1574	m-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1575	p-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	H	CH
1576	H	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1577	o-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1578	m-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1579	p-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1580	o-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1581	m-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1582	p-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1583	o-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1584	m-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1585	p-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1586	o-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1587	m-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1588	p-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1589	o-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1590	m-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1591	p-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1592	o-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1593	m-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1594	p-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1595	p-I	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1596	o-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1597	m-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1598	p-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1599	o-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1600	m-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1601	p-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1602	o-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1603	m-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1604	p-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1605	o-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1606	m-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1607	p-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1608	o-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1609	m-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1610	p-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	Me	CH
1611	H	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1612	o-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1613	m-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1614	p-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1615	o-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1616	m-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1617	p-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1618	o-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1619	m-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1620	p-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1621	o-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1622	m-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1623	p-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1624	o-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1625	m-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1626	p-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1627	o-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1628	m-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1629	p-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1630	p-I	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1631	o-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1632	m-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1633	p-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1634	o-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1635	m-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1636	p-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1637	o-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1638	m-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1639	p-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1640	o-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1641	m-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1642	p-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1643	o-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1644	m-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1645	p-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2F	CH
1646	H	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1647	o-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1648	m-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1649	p-OCH3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1650	o-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1651	m-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1652	p-Cl	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1653	o-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1654	m-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1655	p-Br	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1656	o-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1657	m-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1658	p-NH2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1659	o-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1660	m-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1661	p-NO2	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1662	o-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1663	m-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1664	p-OC2H5	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1665	p-I	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1666	o-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1667	m-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1668	p-O-n-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1669	o-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1670	m-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1671	p-O-i-Pr	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1672	o-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1673	m-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1674	p-O-n-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1675	o-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1676	m-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1677	p-O-i-Bu	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1678	o-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1679	m-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH
1680	p-OCF3	CH2CH2S-CO-i-Pr	CH2CH2S-CO-i-Pr	CH2OH	CH