Core-shell microneedle platform for transdermal and pulsatile drug/vaccine delivery and method of manufacturing the same

Patent Citations (244)

Non-Patent Literature (433)

• Curry et al., Supporting Information Appendix. Biodegradable piezoelectric force sensor. PNAS. Jan. 2018 pp. 1-33 (Year: 2018).Applicant
• Amini et al., “Bone tissue engineering: recent advances and challenges,” Critical Reviews™ in Biomedical Engineering, 2012, 40,(5):363-408.Applicant
• Ando et al., “Film sensor device fabricated by a piezoelectric poly(L-lactic acid) film”, 2012, Jpn J Appl Phys 51:09LD14.Applicant
• Ando et al., “Pressure-sensitive touch panel based on piezoelectric poly (l-lactic acid) film”, 2013, Jpn. J. Appl. Phys. 52:09KD17.Applicant
• Anglen, “The clinical use of bone stimulators,” Journal of the Southern Orthopaedic Association, 2002, 12, (2), 46-54.Applicant
• Bauer et al., “Bone Graft Materials: An Overview of the Basic Science,” Clinical orthopaedics and related research, 2000, 371, 10-27.Applicant
• Bello et al., “Development of a smart pump for monitoring and controlling intraocular pressure”, Ann Biomed Eng 45:990-1002, 2017.Applicant
• Bos et al., “Resorbable poly(L-lactide) plates and screws for the fixation of zygomatic fractures”, 1987, J Oral Maxillofac Surg, 45:751-753.Applicant
• Boutry et al., “A sensitive and Biodegradable Pressure Sensor Array For Cardiovascular Monitoring”, Advanced Materials, 27, 2015, pp. 6954-6961.Applicant
• Bussemer et al., “Pulsatile drug-delivery systems,” Crit Rev Ther Drug Syst., 2001, 18(5):433-458, Abstract.Applicant
• Carpentier et al., “Clinical trial of blood-brain barrier disruption by pulsed ultrasound,” Science translational medicine, 2016, 8(343):343re2, 9 pages.Applicant
• Chee et al., “An investigation of array of piezoelectric transducer for raindrop energy harvesting application”, 2016, IEEE Region Tenth Conference, pp. 3771-3774.Applicant
• Chen et al., “Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination,” Biomaterials, 2013, 34(12):3077-3086.Applicant
• Chiappini et al., “Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization,” Nature Materials, 2015, 14:532-539.Applicant
• Cohen et al., “Totally implanted direct current stimulator as treatment for a nonunion in the foot,” The Journal of foot and ankle surgery: official publication of the American College of Foot and Ankle Surgeons, 1993, 32, (4), 375-381.Applicant
• Csafeglobal, The Cost of a Broken Vaccine Cold Chain Part Two, Financial Cost. <http://csafeglobal.com/the-cost-of-a-broken-vaccine-cold-chain-part-two-financial-cost-1> Sep. 17, 2014, 3 pages.Applicant
• Curry et al., “Biodegradable piezoelectric force sensor,” PNAS, 2018, 115(5):909-914.Applicant
• Dagdeviren et al., “Recent progress in flexible and stretchable piezoelectric devices for mechanical energy harvesting, sensing and actuation,” Extreme Mechanics Letters, 2016, 9(1):269-281.Applicant
• Dai et al., “Electrospun emodin polyvinylpyrrolidone blended nanofibrous membrane: a novel medicated biomaterial for drug delivery and accelerated wound healing,” Journal of Materials Science: Materials in Medicine, 2012, 23(11):2709-2716.Applicant
• Demiray, “Electro-mechanical remodelling of bones,” International Journal of Engineering Science, 1983, 21, (9), 1117-1126.Applicant
• Di Mario et al., “Drug-eluting bioabsorbable magnesium stent”, 2004, J Interv Cardiol., 17:391-395.Applicant
• D'Lima et al. “Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo”, Arthritis Research and Therapy, 2013, 15: 203.Applicant
• European Patent Office Extended Search Report for Application No. 18767093.0 dated Nov. 27, 2020 (13 pages).Applicant
• European Patent Office Partial Search Report for Application No. 19764864 dated Dec. 21, 2021 (12 pages).Applicant
• Ewald et al., “Monitoring of vital signs for long-term survival of mice under anesthesia”, 2011, Cold Spring Harb Protoc. 2011:pdb.prot5563.Applicant
• Ferreira et al., “Bone Collagen Role in Piezoelectric Mediated Remineralization,” Acta Microscopica, 2009, 18(3):278-286.Applicant
• Fukada, “New Piezoelectric polymers” 1998, Jpn J Appl Phys 37:2775-2780.Applicant
• Glazner et al., “Cost of vaccine administration among pediatric practices,” Pediatrics, 2009, 124(Supplement 5):S492-S498.Applicant
• Graf et al., “In Stimulation of bone growth by implanted FEP electrets and PVDF piezoelectric films,” Proceedings 5th International Symposium on Electrets (ISE 5), Heidelberg, 1985, pp. 813-818.Applicant
• Guo et al., “Measurements of piezoelectric coefficient d33 of lead zirconate titanate thin films using a mini force hammer”, 2013, J Vib Accoust, 135:011003.Applicant
• Habibovic, “Strategic directions in osteoinduction and biomimetics,” Tissue Engineering Part A, 2017, 23, (23-24), 1295-1296.Applicant
• International Preliminary Report on Patentability for Application No. PCT/US2018/022441 dated Sep. 17, 2019 (10 pages).Applicant
• International Search Report and Written Opinion for Application No. PCT/US2018/022441 dated Aug. 1, 2018 (12 pages).Applicant
• International Search Report and Written Opinion for Application No. PCT/US2019/020838 dated Jun. 26, 2019 (14 pages).Applicant
• Jayson et al., “Intra-articular pressure in rheumatoid arthritis of the knee 3. Pressure changes during joint use”, Ann Rheum Dis, 1970, 29:401-408.Applicant
• Kang et al., “Bioresorbable silicon electronic sensors for the brain”, Nature, 2016, 530:71-76.Applicant
• Klosterhoff et al., “Implantable Sensors for Regenerative Medicine”, Journal of Biomechanical Engineering, ASME Feb. 2017, vol. 139, 021009-1.Applicant
• Laurencin et al., “Bone graft substitutes,” Expert Review of Medical Devices, 2006, 3(1):49-57.Applicant
• Laurencin et al., “Regenerative engineering,” Science translational medicine, 2012, 4(160): 160ed9, 4 pages.Applicant
• Laurencin et al., “Tissue engineering: orthopedic applications,” Annual review of biomedical engineering, 1999, 1, (1), 19-46.Applicant
• Lee et al., “Micromachined piezolectric force senors based on PZT thin films”, 1996, IEEE Trans Ultrason Farroelectri Freq Control, 43:553-559.Applicant
• Liu et al., “Design and development of three-dimensional scaffolds for tissue engineering”, 2007, Chem Eng Res Des, 85:1051-1064.Applicant
• Madlon-Kay et al., “Too many shots? Parent, nurse, and physician attitudes toward multiple simultaneous childhood vaccinations,” Archives of Family Medicine, 1994, 3(7):610-13.Applicant
• Maloney et al., “Intracranial pressure monitoring in acute liver failure: Institutional case series”, 2016, Neurocrit Care 25:86-93.Applicant
• Mchugh et al., Fabrication of fillable microparticles and other complex 3D microstructures, Science, 2017, 357(6356):1138-1142.Applicant
• Mchugh et al., “Single-injection vaccines: Progress, challenges, and opportunities,” Journal of Controlled Release, 2015, 219:596-609.Applicant
• Meng et al., “A Hybrid Inductive-Ultrasonic Link for Wireless Power Transmission to Millimeter-Sized Biomedical Implats,” IEEE Transactions on Circuits and Systems—II: Express Briefs, 2017, 64(10):1137-1141.Applicant
• Minary-Jolandan et al., “Nanoscale characterization of isolated individual type I collagen fibrils: Polarization and piezoelectricity”, 2009, Nanotechnology 20:085706.Applicant
• Narayanan et al., “Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering,” Advanced drug delivery reviews, 2016, 107, 247-276.Applicant
• Nguyen et al., “Piezoelectric nanoribbons for monitoring cellular deformations,” Nature Nanotechnology, 2012, 7:587-593.Applicant
• Nguyen et al., “Wafter-scale nanopatterning and translation into high-performance piezoelectric nanowires”, 2010, Nano Lett 10: 4595-4599.Applicant
• Nguyen, et al., “Bionics in tissue engineering” 2017, Tissue Engineering for Artifical Organs, pp. 677-669.Applicant
• Poeggel et al., “Optical Fibre Pressure Sensors in Medical Applications,” Sensors, 2015, 15(7):17115-17148.Applicant
• Qi et al., “Enhanced piezoelectricity and stretchability in energy harvesting devices fabricated from buckled PZT ribbons”, 2011, Nano Lett. 11:1331-1336.Applicant
• Qi et al., “Stretchable piezoelectric nanoribbons for biocompatible energy harvesting”, Stretchable Electrionics, pp. 111-139.Applicant
• Ramadan et al., “A review of piezoelectric polymers as functional materials for electromechanical transducers,” Smart Materials and Structures 23, 2014, 033001.Applicant
• Rolland et al., “Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials,” Journal of the American Chemical Society, 2005, 127(28):10096-10100.Applicant
• Ru et al., “Dominant B-form of poly(l-lactic acid) obtained directly from melt under shear and pressure fields”, 2016, Macromolecules 49:3826-3837.Applicant
• Sanni et al., “Inductive and Ultrasonic Multi-Tier Interface for Low-Power, Deeply Implantable Medical Devices,” IEEE Transactions on Biomedical Circuits and Systems, 2012, 6(4):297-308.Applicant
• Sara Vanos et al., “Layerwise mechanics and finite element for the dynamic analysis of piezoelectric composite plates”, 1997, Int J Solids Struct 34:359-378.Applicant
• Sawano et al., “New design of actuator using shear piezoelectricity of a chiral polymer, and prototype device”, 2010, Polym. Int. 59: 365-370.Applicant
• Seol et al., “Hysteretic behavior of contact force response in triboelectric nanogenerator”, 2017, Nano Energy 32:408-413.Applicant
• Shende et al., Micro to nanoneedles: a trend of modernized transepidermal drug delivery system, Artificial Cells, Nanomedicine, and Biotechnology, 2017, 8 pages.Applicant
• Simonelli et al., “Dissolution rates of high energy polyvinylpyrrolidone (PVP)-sulfathiazole coprecipitates,” Journal of pharmaceutical sciences, 1969, 58(5):538-549.Applicant
• Sinderby et al., “Diaphragm activation during exercise in chronic obstructive pulmonary disease”, 2001, Am J Respir Crit Care Med, 163:1637-1641.Applicant
• Soltman et al., “Inkjet-printed line morphologies and temperature control of the coffee ring effect,” Langmuir, 2008, 24(5):2224-2231.Applicant
• Sullivan et al., “Dissolving polymer microneedle patches for influenza vaccination,” Nature medicine, 2010, 16(8):915-921.Applicant
• Syuhei et al., “Sensing using piezoelectric chiral polymer fiber”, 2012, Jpn. J. Appl. Phys. 51:09LD16.Applicant
• Tajitsu et al., “Microactuators with piezoelectric polylactic acid fibers—toward the realizaation of tweezers for biological cells”, 2004, Ferroelectrics 304:195-200.Applicant
• Talmor et al., “Mechanical ventilation guided by esophageal pressure in acute lung injury”, N. Engl. J Med., 2008, 359, 2095-2104.Applicant
• Tanimoto et al., “Effect of helix inversion of poly(β-phenethyl l-aspartate) on macroscopic piezoelectricity,” Japanese Journal of Applied Physics, 2014, 53(9S):09PC01.Applicant
• Vaers, Vaccine Adverse Event Reporting System. <https://vaers.hhs.gov/data/index> webpage available as early as Oct. 9, 2009, 2 pages.Applicant
• Xu et al., “Future of the particle replication in nonwetting templates (PR.INT) technology,” Angewandte Chemie International Edition, 2013, 52(26):6580-6589.Applicant
• Xu et al., “Improvements of thermal property and crystallization behavior of PLLA based multiblock copolymer by forming sterocomplex with PDLA oligomer”, 2006, Polymer (Guildf), 47:3922-3928.Applicant
• Yoshida et al., “High piezoelectric performance of poly (lactic acid) film manufactured by solid state extrusion”, 2014, Jpn. J. Appl. Phys. 53:09PC02.Applicant
• Yoshida et al., “Piezolectric motion of multilayer film with alternate rows of optical isomers of chiral polymer film”, 2011, Jpn J Appl Phys 50:09ND13.Applicant
• Yu et al., “Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers,” Nanotechnology, 2009, 20(5):055104, 9 pages.Applicant
• Zhang et al., “Piezoelectric polymer multilayer on flexible substrate for energy harvesting,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2013, 60(9):2013-2020.Applicant
• Zheng et al., “Biodegradable triboelectric nongenerator as a life-time designed implantable power source”, 2016, Sci Adv 2:e1501478.Applicant
• Zi et al., “Triboelectric-pyroelectric-piezoelectric hybrid cell for high-efficiency energy-harvesting and self-powered sensing”, Adv Mater 27:2340-2347, 2015.Applicant
• Abcam. ELISA kit for MCP-1. https://www.abcam.com/rat-mcp1-elisa-kit-ab219045.html. Accessed Aug. 22, 2022 (5 pages).Applicant
• Abcam. ELISA kit for TNF-alpha. https://www.abcam.com/rat-tnf-alpha-elisa-kit-ab236712.html. Accessed Aug. 22, 2022 (5 pages).Applicant
• AFPRO Filters. Pm1: The Most Hazardous Kind of Particulate Matter. https://web.archive.org/web/20200609213853/https://www.afprofilters.com/pm1-airfilter/, Jun. 9, 2020, (4 pages).Applicant
• Ager, D. J. et al. Stability of aspirin in solid mixtures. Journal of pharmaceutical sciences 1986, 75, (1), 97-101.Applicant
• Alemdaroǧlu, C.; et al. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns 2006, 32, (3), 319-327.Applicant
• Alneami AQ, et al. Effect of Electrical Current Stimulation on Pseudomonas Aeruginosa Growth. Journal of Physics: Conference Series. 2018;1003:012112.Applicant
• Amirnasr, E. et al. Basis Weight Uniformity Analysis in Nonwovens. The Journal of The Textile Institute 2014, 105 (4), 444-453.Applicant
• Ando et al., “New human machine interface devices using a piezoelectric poly(L-lactic acid) film” in 2013 IEEE International Symposium on the Applications of Ferroelectric and Workshop on the Piezoresponse Force Microscopy (ISAF/PFM) (IEEE, 2013), pp. 236-239.Applicant
• Arakha M, et al. The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle. Scientific Reports. 2015;5(1):9578.Applicant
• Asadi MR, et al. Bacterial Inhibition by Electrical Stimulation. Advances in Wound Care. 2013;3(2):91-97.Applicant
• Atkins et al. Raman spectroscopy of blood and blood components. Appl. Spectrosc. 71, 767-793 (2017).Applicant
• Babu, R. et al. Assessment of skin irritation and molecular responses in rat skin exposed to nonane, dodecane and tetradecane. Toxicology letters 2004, 153, (2), 255-266.Applicant
• Bai, Y.; et al. Washable Multilayer Triboelectric Air Filter for Efficient Particulate Matter Pm2. 5 Removal. Advanced Functional Materials 2018, 28 (15), 1706680.Applicant
• Baker, B., et al. Electrical stimulation of articular cartilage regeneration. Annals of the New York Academy of Sciences 238, 491-499 (1974).Applicant
• Banerjee J, et al. Silver-zinc redox-coupled electroceutical wound dressing disrupts bacterial biofilm. PLoS One. 2015;10(3):e0119531-e0119531.Applicant
• Barbour, K. E.; et al., Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010-2012. MMWR. Morbidity and mortality weekly report 2013, 62, (44), 869-873.Applicant
• Barbour, K. E.; et al., Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2013-2015. MMWR. Morbidity and mortality weekly report 2017, 66, (9), 246-253.Applicant
• Barki KG, et al. Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing. Ann Surg. 2019;269(4).Applicant
• Barton, N. J.; et al., Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints. Journal of Inflammation 2007, 4, (1), 13.Applicant
• Bastaki, S. M.; et al. Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E 2 and thromboxane A 2 levels in the anaesthetized rats in vivo. Molecular and cellular biochemistry 2018, 438, (1-2), 25-34.Applicant
• Baur D, Gladstone BP, Burkert F, Carrara E, Foschi F, Dobele S, Tacconelli E: Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis. Lancet Infect Dis 2017, 17(9):990-1001.Applicant
• BCC Research—Global Markets for Drug-Device Combinations, Jan. 2015. PHM045D.Applicant
• Beaudet J, Tulman ER, Pflaum K, Liao X, Kutish GF, Szczepanek SM, Silbart LK, Geary SJ: Transcriptional Profiling of the Chicken Tracheal Response to Virulent Mycoplasma gallisepticum Strain Rlow. Infect Immun 2017, 85(10).Applicant
• Bergsma JE, et al. Late degradation tissue response to poly(l-lactide) bone plates and screws. Biomaterials. 1995;16(1):25-31.Applicant
• Besinis, A.; et al. Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings. Nanotoxicology 2017, 11, (3), 327-338.Applicant
• Bir SC, et al. Control of angiogenesis dictated by picomolar superoxide levels. Free Radic Biol Med. 2013;63:135-142.Applicant
• Blake KM, Carrigan SO, Issekutz AC, Stadnyk AW: Neutrophils migrate across intestinal epithelium using beta2 integrin (CD11b/CD18)-independent mechanisms. Clin Exp Immunol 2004, 136(2):262-268.Applicant
• Bloomberg News. Mask Mandates by Nation: Most Still Await a Breath of Fresh Air. https://www.bloomberg.com/news/articles/2021-05-14/mask-mandates-by-nation-most-still-await-a-breath-of-fresh-air. May 14, 2021 (9 pages).Applicant
• Boks NP, et al. Forces involved in bacterial adhesion to hydrophilic and hydrophobic surfaces. Microbiology. 2008;154(Pt 10):3122-3133.Applicant
• Bose, S.; et al. A review on advances of sustained release drug delivery system. Int. Res. J. Pharm 2013, 4, 1-4.Applicant
• Boster Bio. ELISA kit for IL-1 alpha. https://www.bosterbio.com/rat-il-1-alpha-picokine-trade-elisa-kit-ek0390-boster.html#bs_references. Jul. 1, 2013. Accessed on Aug. 22, 2022. (8 pages).Applicant
• Bottino, M. C. et al. in Biomaterials for Oral and Craniomaxillofacial Applications vol. 17 90-100 (Karger Publishers, 2015).Applicant
• Boutry et al., A stretchable and biodegradable strain and pressure sensor for orthopaedic application. Nat. Electron. 1, 314-321 (2018).Applicant
• Boutry et al., Biodegradable and flexible arterial-pulse sensor for the wireless monitoring of blood flow. Nat. Biomed. Eng. 3, 47-57 (2019).Applicant
• Bronaugh, R. L.; et al., Differences in permeability of rat skin related to sex and body site. J. Soc. Cosmet. Chem 1983, 34, (12), 127-135.Applicant
• Brooks, J. T.; et al., Effectiveness of Mask Wearing to Control Community Spread of Sars-Cov-2. Jama 2021, 325 (10), 998-999.Applicant
• Brune, K.; et al. Recent Insight into the Mechanism of Gastrointestinal Tract Ulceration. Scandinavian Journal of Rheumatology 1987, 16, (sup65), 135-140.Applicant
• Byrne, J. D.; et al., Injection Molded Autoclavable, Scalable, Conformable (Imasc) System for Aerosol-Based Protection: A Prospective Single-Arm Feasibility Study. BMJ open 2020, 10 (7), e039120.Applicant
• Caballe-Serrano, J. et al. On the search of the ideal barrier membrane for guided bone regeneration. Journal of clinical and experimental dentistry 10, e477 (2018).Applicant
• Cadavid, A. P., Aspirin: the mechanism of action revisited in the context of pregnancy complications. Frontiers in immunology 2017, 8, 261.Applicant
• Campbell, C. L. et al. Aspirin dose for the prevention of cardiovascular disease: a systematic review. Jama 2007, 297, (18), 2018-2024.Applicant
• Carvalho, E. O., et al. “Tailoring bacteria response by piezoelectric stimulation.” ACS applied materials & interfaces 11.30 (2019): 27297-27305.Applicant
• Caspani, M. Delta Variant Pushes US Cases Hospitalizations 6 Month High. Aug. 9, 2021. https://web.archive.org/web/20210809174911/https://www.reuters.com/world/us/delta-variant-pushes-us-cases-hospitalizations-6-month-high-2021-08-09/ (12 pages).Applicant
• CDC. Antibiotic resistance threats in the United States, 2019. US Department of Health and Human Services. 2019 (150 pages).Applicant
• CDC. Implementing Filtering Facepiece Respirator (Ffr) Reuse, Including Reuse after Decontamination, When There Are Known Shortages of N95 Respirators. https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/decontamination-reuse-respirators.html, Oct. 19, 2020, (10 pages).Applicant
• CDC. Periodontal Disease. <https://www.cdc.gov/oralhealth/conditions/periodontal-disease.html> (Jul. 10, 2013) (3 pages).Applicant
• CDC. Personal Protective Equipment: Questions and Answers. https://www.cdc.gov/coronavirus/2019-ncov/hcp/respirator-use-faq.html (Apr. 9, 2021) (6 pages).Applicant
• Chang et al., Biodegradable electronic systems in 3D, heterogeneously integrated formats. Adv. Mater. 30, 1704955 (2018).Applicant
• Chatterjee, A.; et al., In vitro and in vivo comparison of dermal irritancy of jet fuel exposure using EpiDerm™(EPI-200) cultured human skin and hairless rats. Toxicology letters 2006, 167, (2), 85-94.Applicant
• Chen, C.-C.; et al. Aerosol Penetration through Surgical Masks. American journal of infection control 1992, 20 (4), 177-184.Applicant
• Chen, M.-C. et al. Implantable polymeric microneedles with phototriggerable properties as a patient-controlled transdermal analgesia system. Journal of Materials Chemistry B 2017, 5, (3), 496-503.Applicant
• Cheng, Y.; et al. Face Masks Effectively Limit the Probability of Sars-Cov-2 Transmission. Science 2021 1439-1443.Applicant
• Choi, S.; et al. Biodegradable, Efficient, and Breathable Multi-Use Face Mask Filter. Advanced Science 2021, 8 (6), 2003155.Applicant
• Chorsi MT, et al. Piezoelectric Biomaterials for Sensors and Actuators. Advanced Materials. 2019;31(1):1802084.Applicant
• Chu et al., “Piezoelectric stimulation by ultrasound facilitates chondrogenesis of mesenchymal stem cells”, J Acoustical Society of American, 2020, vol. 148, No. 1, pp. EL58-EL64.Applicant
• Chu, D. K.; et al. Physical Distancing, Face Masks, and Eye Protection to Prevent Person-to-Person Transmission of Sars-Cov-2 and Covid-19: A Systematic Review and Meta-Analysis. The lancet 2020, 395 (10242), 1973-1987.Applicant
• Chu, J.; et al. Thinking Green: Modelling Respirator Reuse Strategies to Reduce Cost and Waste. BMJ open 2021, 11 (7), e048687.Applicant
• Clearfield, D. S., et al. Osteochondral Differentiation of Fluorescent Multireporter Cells on Zonally-Organized Biomaterials. Tissue Engineering Part A 25, 468-486 (2019).Applicant
• Cohen, A. J.; et al. Estimates and 25-Year Trends of the Global Burden of Disease Attributable to Ambient Air Pollution: An Analysis of Data from the Global Burden of Diseases Study 2015. The Lancet 2017, 389 (10082), 1907-1918.Applicant
• Combe, R.; et al. The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats? Neuroscience letters 2004, 370, (2-3), 236-240.Applicant
• Cooper MA, et al. Fix the antibiotics pipeline. Nature. 2011;472(7341):32-32.Applicant
• Creech et al., “Prevention of Recurrent Staphylococcal Skin Infections,” Infect Dis Clin North Am. Sep. 2015; 29(3): 429-464.Applicant
• Crofford, L. J., Use of NSAIDs in treating patients with arthritis. Arthritis research & therapy 2013, 15, (3), S2 (10 pages).Applicant
• Crone S, et al. A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement. J Wound Care. 2015;24(2):64-72.Applicant
• Cui, et al. Study on a piezoelectric micropump for the controlled drug delivery system. Microfluid. Nanofluidics 3, 377-390 (2007).Applicant
• Curdy, C. et al. Piroxicam delivery into human stratum corneum in vivo: iontophoresis versus passive diffusion. Journal of Controlled Release 2001, 76, (1-2), 73-79.Applicant
• Curry EJ, et al. Biodegradable nanofiber-based piezoelectric transducer. Proceedings of the National Academy of Sciences. 2020;117(1):214-220.Applicant
• Curry, E. J.; et al. 3D nano- and micro-patterning of biomaterials for controlled drug delivery. Therapeutic Delivery 2016.Applicant
• Da Silva et al., Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems. Chem. Eng. J. 340, 9-14 (2018).Applicant
• Daeschlein G, et al. Antibacterial activity of positive and negative polarity low-voltage pulsed current (LVPC) on six typical Gram-positive and Gram-negative bacterial pathogens of chronic wounds. Wound Repair Regen. 2007;15(3):399-403.Applicant
• Dagdeviren C, et al. Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring. Nature Communications. 2014;5(1):4496.Applicant
• Dagdeviren C, et al. Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm. Proceedings of the National Academy of Sciences. 2014;111(5):1927.Applicant
• Das, R. et al. Biodegradable Nanofiber Bone-Tissue Scaffold as Remotely-Controlled and Self-Powering Electrical Stimulator. Nano Energy 2020, 105028.Applicant
• Davidson, C. I.; et al. Airborne Particulate Matter and Human Health: A Review. Aerosol Science and Technology 2005, 39 (8), 737-749.Applicant
• Degenhart et al., Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. 13, 046019 (2016).Applicant
• Deleo et al., “Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era,” JCL, 2009, 119, 2464-2474.Applicant
• Deleo FR, Diep BA, Otto M: Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am 2009, 23(1):17-34.Applicant
• Derakhshandeh H, et al. A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays. Adv Funct Mater. 2020;30(13):1905544.Applicant
• Desai, T. A.; et al., Nanoporous implants for controlled drug delivery. In BioMEMS and Biomedical Nanotechnology, Springer: 2006; pp. 263-286.Applicant
• Dimitroulas, T.; et al. In Biologic drugs as analgesics for the management of osteoarthritis, Seminars in arthritis and rheumatism, 2017; Elsevier: pp. 687-691.Applicant
• Dixon, W. J. et al. A method for obtaining and analyzing sensitivity data. Journal of the American Statistical Association 1948, 43, (241), 109-126.Applicant
• Dominguez, C. A. et al. Sex differences in the development of localized and spread mechanical hypersensitivity in rats after injury to the infraorbital or sciatic nerves to create a model for neuropathic pain. Gender medicine 2009, 6, 225-234.Applicant
• Dong P-T, et al. Photolysis of Staphyloxanthin in Methicillin-Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species. Advanced Science. 2019;6(11):1900030.Applicant
• Donnelly, R. F.; et al. Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Advanced functional materials 2012, 22, (23), 4879-4890.Applicant
• Draize, J. H. et al. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of pharmacology and Experimental Therapeutics 1944, 82, (3), 377-390.Applicant
• Dwyer DJ, et al. Antibiotics induce redox-related physiological alterations as part of their lethality. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(20):E2100-2109.Applicant
• Englander L, et al. Nitric oxide nanoparticle technology: a novel antimicrobial agent in the context of current treatment of skin and soft tissue infection. J Clin Aesthet Dermatol. 2010;3(6):45-50.Applicant
• Eppley BL, et al. Degradation characteristics of PLLA-PGA bone fixation devices. The Journal of craniofacial surgery. 1997;8(2):116-120.Applicant
• Esposito S, et al. Antimicrobial Treatment of Staphylococcus aureus in Patients With Cystic Fibrosis. Front Pharmacol. 2019;10:849-849.Applicant
• European Patent Office Extended Search Report for Application No. 19764864 dated Mar. 22, 2022 (11 pages).Applicant
• Farah et al. Physical and mechanical properties of PLA, and their functions in widespread applications—a comprehensive review. Adv. Drug Deliv. Rev. 107, 367-392 (2016).Applicant
• FDA. N95 Respirators, Surgical Masks, and Face Masks. https://www.fda.gov/medical-devices/personal-protective-equipment-infection-control/n95-respirators-surgical-masks-face-masks-and-barrier-face-coverings Last updated Jul. 19, 2022 (6 pages).Applicant
• Feng, Y. et al. Engineering Spherical Lead Zirconate Titanate to Explore the Essence of Piezo-Catalysis. Nano Energy 2017, 40, 481-486.Applicant
• Feng, Y.; et al. Self-Powered Electrostatic Filter with Enhanced Photocatalytic Degradation of Formaldehyde Based on Built-in Triboelectric Nanogenerators. ACS nano 2017, 11 (12), 12411-12418.Applicant
• Formenti, D.; et al. Thermal imaging of exercise-associated skin temperature changes in trained and untrained female subjects. Annals of biomedical engineering 2013, 41, (4), 863-871.Applicant
• Fosslien, E., Adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal system. Annals of Clinical & Laboratory Science 1998, 28, (2), 67-81.Applicant
• Foti JJ, et al. Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics. Science. 2012;336(6079):315-319.Applicant
• Freeman J, et al. Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection. J Antimicrob Chemother. 2005;56(4):717-725.Applicant
• Friebe, M.; et al. Synovial distribution of “systemically” administered acetylsalicylic acid in the isolated perfused equine distal limb. BMC veterinary research 2013, 9, (1), 56.Applicant
• Frim, J. et al. Body composition and skin temperature variation. Journal of Applied Physiology 1990, 68, (2), 540-543.Applicant
• Fu, C.-H. J. et al. Method for determination of aspirin and salicylic acid in rat whole blood by high pressure liquid chromatography. Analytical Letters 1985, 18, (3), 269-277.Applicant
• Gabriel D, et al. A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials. 2013;34(38):9763-9769.Applicant
• Gao, Q., et al. Ultrasound Stimulation of Different Dental Stem Cell Populations: Role of Mitogen-activated Protein Kinase Signaling. J. Endod. 42, 2016, 425-431.Applicant
• Garland MJ(1), Migalska K, Mahmood TM, Singh TR, Woolfson AD, Donnelly RF. Microneedle arrays as medical devices for enhanced transdermal drug delivery Expert Rev Med Devices. Jul. 2011;8(4):459-82.Applicant
• Gentile, P. et al. An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. International journal of molecular sciences 2014, 15, (3), 3640-3659.Applicant
• Gibaldi, M. et al. Bioavailability of aspirin from commercial suppositories. Journal of pharmaceutical sciences 1975, 64, (6), 1064-1066.Applicant
• Gohil, S. V. et al. Spatially controlled rhBMP-2 mediated calvarial bone formation in a transgenic mouse model. International journal of biological macromolecules 2018, 106, 1159-1165.Applicant
• Golabchi et al., Melatonin improves quality and longevity of chronic neural recording. 180, 225-239 (2018).Applicant
• Gordon CP, Williams P, Chan WC: Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective. J Med Chem 2013, 56(4):1389-1404.Applicant
• Gottlieb, H. E.; et al. Nmr Chemical Shifts of Common Laboratory Solvents as Trace Impurities. Journal of Organic Chemistry 1997, 62 (21), 7512-7515.Applicant
• Grant SS, et al. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proceedings of the National Academy of Sciences. 2012; 109(30):12147.Applicant
• Grassi, M.; et al. Mathematical modelling and controlled drug delivery: matrix systems. Current drug delivery 2005, 2, (1), 97-116.Applicant
• Gu, G. Q. et al. Triboelectric Nanogenerator Enhanced Nanofiber Air Filters for Efficient Particulate Matter Removal. Acs Nano 2017, 11 (6), 6211-6217.Applicant
• Guerin et al., Control of piezoelectricity in amino acids by supramolecular packing. Nat. Mater. 17, 180-186 (2018).Applicant
• Guo, H.; et al. A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: in vitro and in vivo studies. Acta Biomater. 2020, 396-409.Applicant
• Gurung, D. et al. Transient temperature distribution in human dermal part with protective layer at low atmospheric temperature. International Journal of Biomathematics 2010, 3, (04), 439-451.Applicant
• Gustafsson, M. et al. Pain, coping and analgesic medication usage in rheumatoid arthritis patients. Patient education and counseling 1999, 37, (1), 33-41.Applicant
• Gutarowska, B., et al. “PLA nonwovens modified with poly (dimethylaminoethyl methacrylate) as antimicrobial filter materials for workplaces.” Textile Research Journal 85.10 (2015): 1083-1094.Applicant
• Haddadin et al., “Methicillin resistant Staphylococcus aureus (MRSA) in the intensive care unit,” Postgraduate Medical Journal 2002; 78:385-392.Applicant
• Hasuike A, et al. In vivo bone regenerative effect of low-intensity pulsed ultrasound in rat calvarial defects. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011;111(1):e12-e20.Applicant
• Hauert AB, Martinelli S, Marone C, Niggli V: Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int J Biochem Cell Biol 2002, 34(7):838-854.Applicant
• He, M. et al. Intradermal implantable PLGA microneedles for etonogestrel sustained release. Journal of Pharmaceutical Sciences 2020, 1958-1966.Applicant
• He, Z. et al. An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis. Colloids and Surfaces B: Biointerfaces 2017, 154, 33-39.Applicant
• Hickey, D.J., et al. Electrophoretic deposition of MgO nanoparticles imparts antibacterial properties to poly-L-lactic acid for orthopedic applications. Journal of Biomedical Materials Research Part A, 2017, 105(11), 3136-3147.Applicant
• Hong K-S, et al. Piezoelectrochemical Effect: A New Mechanism for Azo Dye Decolorization in Aqueous Solution through Vibrating Piezoelectric Microfibers. The Journal of Physical Chemistry C. 2012;116(24):13045-13051.Applicant
• Horodyckid et al., Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: A multiparametric study in a primate model. J. Neurosurg. 126, 1351-1361 (2017).Applicant
• Hossain, E.; et al. Recharging and Rejuvenation of Decontaminated N95 Masks. Physics of Fluids 2020, 32 (9), 093304.Applicant
• Howard, J.; et al., An Evidence Review of Face Masks against Covid-19. Proceedings of the National Academy of Sciences 2021, 118 (4).Applicant
• Hu H, et al. Stretchable ultrasonic transducer arrays for three-dimensional imaging on complex surfaces. Science Advances. 2018;4(3):eaar3979.Applicant
• Huang, X.; et al. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. Journal of controlled release 2001, 73, (2-3), 121-136.Applicant
• Huij, et al. Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA. Advanced Science. 2020;7(6):1903117.Applicant
• Iati, M. More Experts Now Recommend Medical Masks. Good Ones Are Hard to Find. Feb. 2, 2021. https://www.washingtonpost.com/health/2021/02/02/medical-mask-shortage/ (4 pages).Applicant
• IDATA Reasearch. 2017 US Dental Barrier Membrane Market Driven by Increased Use of Resorbable Membranes. https://idataresearch.com/2017-US-dental-barrier-membrane-market-driven-increased-use-resorbable-membranes/. Nov. 10, 2017. (6 pages).Applicant
• Idbaih et al., Safety and feasibility of repeated and transient blood-brain barrier disruption by pulsed ultrasound in patients with recurrent glioblastoma. Clin. Cancer Res. 25, 3793-3801 (2019).Applicant
• Ikada et al. Enhancement of bone formation by drawn poly(L-lactide). J. Biomed. Mater. Res. 30, 553-558 (1996).Applicant
• Indian Office Action for Application 202037042930 dated Jun. 20, 2022 (6 pages).Applicant
• Infection Control Today, “New Research Estimates MRSA Infections Cost U.S. Hospitals $3.2 Billion to $4.2 Billion Annually,” <https://www.infectioncontroltoday.com/view/new-research-estimates-mrsa-infections-cost-us-hospitals-32-billion-42-billion-annually> dated May 16, 2005.Applicant
• Institute of Medicine of the National Academies. Characteristics of Respirators and Medical Masks. In Reusability of Facemasks During an Influenza Pandemic: Facing the Flu, 2006; pp. 22-42.Applicant
• International Preliminary Report on Patentability for Application No. PCT/US2021/021677 dated Sep. 6, 2022 (11 pages).Applicant
• International Search Report and Written Opinion for Application No. PCT/US21/53887 dated Jan. 28, 2022 (14 pages).Applicant
• Jacobi, U. et al. Porcine ear skin: an in vitro model for human skin. Skin Research and Technology 2007, 13, (1), 19-24.Applicant
• Ji, W. et al. Incorporation of stromal cell-derived factor-1α in PCL/gelatin electrospun membranes for guided bone regeneration. Biomaterials 34, 735-745 (2013).Applicant
• Jin Y, Li M, Shang Y, Liu L, Shen X, Lv Z, Hao Z, Duan J, Wu Y, Chen C et al: Sub-Inhibitory Concentrations of Mupirocin Strongly Inhibit Alpha-Toxin Production in High-Level Mupirocin-Resistant MRSA by Down-Regulating agr, saeRS, and sarA. Front Microbiol 2018, 9:993.Applicant
• Jung, Y.-s. et al. Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery. Carbohydrate polymers 2017, 156, 403-408.Applicant
• Jüni, P.; et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database of Systematic Reviews 2015, (10) (81 pages).Applicant
• Kalali Y, Haghighat S, Mahdavi M: Passive immunotherapy with specific IgG fraction against autolysin: Analogous protectivity in the MRSA infection with antibiotic therapy. Immunol Lett 2019, 212:125-131.Applicant
• Kaushik, S. et al. Lack of pain associated with microfabricated microneedles. Anesthesia & Analgesia 2001, 92, (2), 502-504.Applicant
• Kean, T.; et al. Biodegradation, Biodistribution and Toxicity of Chitosan. Advanced drug delivery reviews 2010, 62 (1), 3-11.Applicant
• Kern, H., et al. Recovery of long-term denervated human muscles induced by electrical stimulation. Muscle & nerve 31, 98-101 (2005).Applicant
• Khalid, B.; et al., Direct Blow-Spinning of Nanofibers on a Window Screen for Highly Efficient Pm2. 5 Removal. Nano letters 2017, 17 (2), 1140-1148.Applicant
• Khanal, M.; et al. Injectable nanocomposite analgesic delivery system for musculoskeletal pain management. Acta biomaterialia 2018, 74, 280-290.Applicant
• Kim, D.-H. et al. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials 2006, 27, (15), 3031-3037.Applicant
• Kinoshita, N. et al. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced bloodbrain barrier disruption. Proc. Natl. Acad. Sci. U.S.A. 103, 11719-11723 (2006).Applicant
• Klein et al., “National Costs Associated With Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Hospitalizations in the United States, 2010-2014,” Clinical Infectious Diseases, vol. 68, Issue 1, Jan. 1, 2019, pp. 22-28.Applicant
• Kloth, L. C. Electrical stimulation for wound healing: a review of evidence from in vitro studies, animal experiments, and clinical trials. The international journal of lower extremity wounds 4, 23-44 (2005).Applicant
• Kobayashi, et al. Label-free imaging of melanoma with confocal photothermal microscopy: Differentiation between malignant and benign tissue. Bioeng. 5, 67 (2018) (18 pages).Applicant
• Kohanski MA, et al. A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics. Cell. 2007;130(5):797-810.Applicant
• Kozai et al., Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes. 35, 9255-9268 (2014).Applicant
• Krasowska A A, et al. How microorganisms use hydrophobicity and what does this mean for human needs? Front Cell Infect Microbiol. 2014;4:112-112.Applicant
• Kullenberg, B. et al. Intraarticular corticosteroid injection: pain relief in osteoarthritis of the hip? The Journal of rheumatology 2004, 31, (11), 2265-2268.Applicant
• Latimer, J. M. et al. Microwave Oven Irradiation as a Method for Bacterial Decontamination in a Clinical Microbiology Laboratory. Journal of Clinical Microbiology 1977, 6 (4), 340-342.Applicant
• Laurencin, C. T.; et al. Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications. Drug discovery today 2014, 19, (6), 794-800.Applicant
• Lausen M, Pedersen MS, Rahman NSK, Holm-Nielsen LT, Farah FYM, Christiansen G, Birkelund S: Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils. Infect Immun 2020, 88(7).Applicant
• Leatherby, L. As Covid Cases Rise All over U.S., Lower Vaccination Rates Point to Worse Outcomes. Jul. 31, 2021. https://www.nytimes.com/interactive/2021/07/31/US/covid-delta-cases-deaths.html?action=click&module=Spotlight&pgtype=Homepage (3 pages).Applicant
• Lee et al., Lactic acid assisted fabrication of bioactive three-dimensional PLLA/β-TCP fibrous scaffold for biomedical application. Chem. Eng. J. 347, 771-781 (2018).Applicant
• Lee, et al. Piezoelectric properties of electrospun poly(L-lactic acid) nanofiber web. Mater. Lett. 148, 58-62 (2015).Applicant
• Leung, L. et al. Comparison of morphology and mechanical properties of PLGA bioscaffolds. Biomedical Materials 2008, 3, (2), 025006.Applicant
• Lewin et al., Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis. Wellcome Open Res. 1, 10 (2016) (23 pages).Applicant
• Lewitus, S. et al. The Effect of Nanoclays on the Properties of PLLA-modified Polymers Part 1: Mechanical and Thermal Properties. Journal of Polymers and the Environment 14, 171-177 (2006).Applicant
• Li J, et al. Evaluation of Ultrasound-Induced Damage to Escherichia coli and Staphylococcus aureus by Flow Cytometry and Transmission Electron Microscopy. Appl Environ Microbiol. 2016;82(6):1828-1837.Applicant
• Liz, et al. Using Positively Charged Magnetic Nanoparticles to Capture Bacteria at Ultralow Concentration. Nanoscale Research Letters. 2019;14(1):195 (8 pages).Applicant
• Li, C. et al. Dual-mode operation of flexible piezoelectric polymer diaphragm for intracranial pressure measurement. Appl. Phys. Lett. 96, 053502 (2010).Applicant
• Li, H. et al. Enhancing the Mechanical Properties of Electrospun Nanofiber Mats through Controllable Welding at the Cross Points. Macromolecular rapid communications 2017, 38 (9), 1600723.Applicant
• Li, N.; et al. A Work Group Report on Ultrafine Particles (American Academy of Allergy, Asthma & Immunology): Why Ambient Ultrafine and Engineered Nanoparticles Should Receive Special Attention for Possible Adverse Health Outcomes in Human Subjects. Journal of Allergy and Clinical Immunology 2016, 138 (2), 386-396.Applicant
• Li, P. et al. Air Filtration in the Free Molecular Flow Regime: A Review of High-Efficiency Particulate Air Filters Based on Carbon Nanotubes. Small 2014, 10 (22), 4543-4561.Applicant
• Li, P. et al. Apatite formation induced by silica gel in a simulated body fluid. Journal of the American Ceramic Society 1992, 75, (8), 2094-2097.Applicant
• Li, Q. et al. Involvement of the spinal NALP1 inflammasome in neuropathic pain and aspirin-triggered-15-epi-lipoxin A4 induced analgesia. Neuroscience 2013, 254, 230-240.Applicant
• Li, W. et al. Rapidly separable microneedle patch for the sustained release of a contraceptive. Nature Biomedical Engineering 2019, 3, (3), 220-229.Applicant
• Li, W.; et al. Long-acting reversible contraception by effervescent microneedle patch. Science advances 2019, 5, (11), eaaw8145.Applicant
• Liao, L.; et al. Can N95 Respirators Be Reused after Disinfection? How Many Times? ACS nano 2020, 14 (5), 6348-6356.Applicant
• Liu, C.; et al. Transparent Air Filter for High-Efficiency Pm 2.5 Capture. Nature communications 2015, 6 (1), 1-9.Applicant
• Liu, G. et al. Self-Powered Electrostatic Adsorption Face Mask Based on a Triboelectric Nanogenerator. ACS applied materials & interfaces 2018, 10 (8), 7126-7133.Applicant
• Liu, H. et al. High-Performance Pm0. 3 Air Filters Using Self-Polarized Electret Nanofiber/Nets. Advanced Functional Materials 2020, 30 (13), 1909554.Applicant
• Liu, X. et al. A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration. Acta Biomater. 2020, 108, 207-222.Applicant
• Liu, Z.; et al. Understanding the Factors Involved in Determining the Bioburdens of Surgical Masks. Annals of translational medicine 2019, 7 (23).Applicant
• Lo, K. et al. Small-molecule based musculoskeletal regenerative engineering. Trends in biotechnology 2014, 32, (2), 74-81.Applicant
• Lobritz MA, et al. Antibiotic efficacy is linked to bacterial cellular respiration. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(27):8173-8180.Applicant
• Lokuta MA, Nuzzi PA, Huttenlocher A: Analysis of neutrophil polarization and chemotaxis. Methods Mol Biol 2007, 412:211-229.Applicant
• Long Y, et al. Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators. ACS Nano. 2018;12(12):12533-12540.Applicant
• Lops, C.; et al. Sonophotocatalytic Degradation Mechanisms of Rhodamine B Dye Via Radicals Generation by Micro-and Nano-Particles of Zno. Applied Catalysis B: Environmental 2019, 243, 629-640.Applicant
• Lu, W.-C. et al. Effect of magnesium on the osteogenesis of normal human osteoblasts. Magnes. Res. 30, 42-52 (2017).Applicant
• Lu, X.; et al. Theoretical analysis of calcium phosphate precipitation in simulated body fluid. Biomaterials 2005, 26, (10), 1097-1108.Applicant
• Ludwig, The velocity of sound through tissues and the acoustic impedance of tissues. The journal of the acoustical society of America 22, 862-866 (1950).Applicant
• Lundgren, D., et al. “The use of a new bioresorbable barrier for guided bone regeneration in connection with implant installation. Case reports.” Clinical Oral Implants Research 5.3 (1994): 177-184.Applicant
• Luque-Agudo V, et al. Aging of Solvent-Casting PLA-Mg Hydrophobic Films: Impact on Bacterial Adhesion and Viability. Coatings. 2019;9(12) 814.Applicant
• Luzuriaga MA(1), Berry DR, Reagan JC, Smaldone RA, Gassensmith JJ. Biodegradable 3D printed polymer microneedles for transdermal drug delivery. Lab Chip. Apr. 17, 2018;18(8):1223-1230.Applicant
• Lv, D.; et al. Ecofriendly Electrospun Membranes Loaded with Visible-Light-Responding Nanoparticles for Multifunctional Usages: Highly Efficient Air Filtration, Dye Scavenging, and Bactericidal Activity. ACS applied materials & interfaces 2019, 11 (13), 12880-12889.Applicant
• Mahdavi, A. et al. Particle Loading Time and Humidity Effects on the Efficiency of an N95 Filtering Facepiece Respirator Model under Constant and Inhalation Cyclic Flows. Annals of Occupational Hygiene 2015, 59 (5), 629-640.Applicant
• Manoukian, M. A. C. et al. Topical administration of ibuprofen for injured athletes: considerations, formulations, and comparison to oral delivery. Sports medicine-open 2017, 3, (1), 36, 1-9.Applicant
• Marzoli, F. et al. Long-lasting, antinociceptive effects of pH-sensitive niosomes loaded with ibuprofen in acute and chronic models of pain. Pharmaceutics 2019, 11, (2), 62, 1-12.Applicant
• Mcallister DV(1), Wang PM, Davis SP, Park JH, Canatella PJ, Allen MG, Prausnitz MR. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc Natl Acad Sci U S A. Nov. 25, 2003;100(24):13755-60.Applicant
• Mccrudden, M. T. et al. Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs. Journal of Controlled Release 2014, 180, 71-80.Applicant
• Mcdannold, et al. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits. Ultrasound Med. Biol. 31, 1527-1537 (2005).Applicant
• Meylan S, et al. Targeting Antibiotic Tolerance, Pathogen by Pathogen. Cell. 2018;172(6):1228-1238.Applicant
• Middleton, J. C.; Tipton, A. J., Synthetic Biodegradable Polymers as Orthopedic Devices. Biomaterials 2000, 21 (23), 2335-2346.Applicant
• Mihai MM, et al. Nanomaterials for Wound Healing and Infection Control. Materials (Basel). 2019;12(13):2176.Applicant
• Millius A, Weiner OD: Chemotaxis in neutrophil-like HL-60 cells. Methods Mol Biol 2009, 571:167-177.Applicant
• Moga, K. A. et al. Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach. Advanced Materials 2013, 25, (36), 5060-5066.Applicant
• Mohseni et al., “Gellan gel comprising short PVDF based-nanofibers: The effect of piezoelectric nanofiber on the mechanical and electrical behavior,” Materialstoday Communications, vol. 26, Mar. 2021, 101785.Applicant
• Monsen T, et al. In Vitro Effect of Ultrasound on Bacteria and Suggested Protocol for Sonication and Diagnosis of Prosthetic Infections. J Clin Microbiol. 2009;47(8):2496-2501.Applicant
• Montgomery CP, Boyle-Vavra S, Daum RS: Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection. PLoS One 2010, 5(12):e15177.Applicant
• Morel CM, et al. Stoking the antibiotic pipeline. BMJ. 2010;340:1115-1118.Applicant
• Nair, L. S.; et al. Polymers as biomaterials for tissue engineering and controlled drug delivery. In Tissue engineering I, Springer: 2005; pp. 47-90.Applicant
• Najdovski, L. et al. The Killing Activity of Microwaves on Some Non-Sporogenic and Sporogenic Medically Important Bacterial Strains. Journal of Hospital Infection 1991, 19 (4), 239-247.Applicant
• Nasajpour, A. et al. A multifunctional polymeric periodontal membrane with osteogenic and antibacterial characteristics. Adv. Funct. Mater. 28, 1703437 (2018).Applicant
• Nazir, M. A. Prevalence of periodontal disease, its association with systemic diseases and prevention. International journal of health sciences 11, 72 (2017), 72-80.Applicant
• Neely RM, et al. Recent advances in neural dust: towards a neural interface platform. Current Opinion in Neurobiology. 2018;50:64-71.Applicant
• Nguyen, “A novel injectable piezoelectric hydrogel for osteoarthritis treatment,” NIH Project No. 1R21AR074645-01, Award notice date: Apr. 23, 2019, Project Start Date: Jun. 1, 2019 <https://reporter.nih.gov/project-details/9651964> (3 pages).Applicant
• Nicosia, A., et al. “Air filtration and antimicrobial capabilities of electrospun PLA/PHB containing ionic liquid.” Separation and Purification Technology 154 (2015): 154-160.Applicant
• Nielsen A, Mansson M, Bojer MS, Gram L, Larsen TO, Novick RP, Frees D, Frokiaer H, Ingmer H: Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils. PLoS One 2014, 9(1):e84992.Applicant
• Noguchi, Y. Why N95 Masks Are Stil in Short Supply in the U.S. https://www.npr.org/sections/health-shots/2021/01/27/960336778/why-n95-masks-are-still-inshort-supply-in-the-u-s, Jan. 27, 2021 (17 pages).Applicant
• Norman, J. J.; et al. Microneedle patches: usability and acceptability for self-vaccination against influenza. Vaccine 2014, 32, (16), 1856-1862.Applicant
• Novotny et al. Molybdenum intake influences molybdenum kinetics in men. J. Nutr. 137, 37-42 (2007).Applicant
• O'Dowd et al., “Face Masks and Respirators in the Fight Against the COVID-19 Pandemic: A Review of Current Materials, Advances and Future Perspectives,” Materials 2020, 13(15), 3363.Applicant
• Olatunji, O.; et al. Microneedle-assisted transdermal delivery of acetylsalicylic acid (aspirin) from biopolymer films extracted from fish scales. Polymer Bulletin 2018, 75, (9), 4103-4115.Applicant
• Omidinia-Anarkoli, A.; et al. An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells. Small 2017, 13, (36).Applicant
• O'Riordan K, Lee JC: Staphylococcus aureus capsular polysaccharides. Clin Microbiol Rev 2004, 17(1):218-234.Applicant
• Padilla F, et al. Stimulation of bone repair with ultrasound: A review of the possible mechanic effects. Ultrasonics. 2014;54(5):1125-1145.Applicant
• Panieri E, et al. ROS signaling and redox biology in endothelial cells. Cell Mol Life Sci. 2015;72(17):3281-3303.Applicant
• Pankey GA, et al. Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections. Clin Infect Dis. 2004;38(6):864-870.Applicant
• Park, J.-H. et al. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. Journal of controlled release 2005, 104, (1), 51-66.Applicant
• Parlet CP, Kavanaugh JS, Crosby HA, Raja HA, El-Elimat T, Todd DA, Pearce CJ, Cech NB, Oberlies NH, Horswill AR: Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Rep 2019, 27(1):187-198 e186.Applicant
• Patel et al., “Development of a Sonically Powered Biodegradable Nanogenerator for Bone Regeneration”, 2019, University of Connecticut, 46 pages.Applicant
• Pathak, R. K. et al. A nanoparticle cocktail: temporal release of predefined drug combinations. Journal of the American Chemical Society 2015, 137, (26), 8324-8327.Applicant
• Patrick, J.; et al. A randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation. Postgraduate medicine 2015, 127, (6), 573-580.Applicant
• Paul, et al. Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. 86, 1-10 (2013).Applicant
• Pavel A, et al. Prophylactic Antibiotics in Clean Orthopaedic Surgery. JBJS. 1974;56(4):777-782.Applicant
• Pelletier, J.-P.; et al. In Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys, Seminars in arthritis and rheumatism, 2016; Elsevier: pp. S22-S27.Applicant
• Peltoniemi et al. SR-PLLA and SRPGA miniscrews: Biodegradation and tissue reactions in the calvarium and dura mater. J. Craniomaxillofac. Surg. 27, 42-50 (1999).Applicant
• Peng, X., et al. “A breathable, biodegradable, antibacterial, and self-powered electronic skin based on all-nanofiber triboelectric nanogenerators.” Science Advances 6.26 (2020): eaba9624.Applicant
• Peterson RV, et al. The effect of frequency and power density on the ultrasonically-enhanced killing of biofilm-sequestered Escherichia coli. Colloids and Surfaces B: Biointerfaces. 2000; 17(4):219-227.Applicant
• Prausnitz, M. R. Engineering microneedle patches for vaccination and drug delivery to skin. Annual review of chemical and biomolecular engineering 2017, 8, 177-200.Applicant
• Pressmeddelande, “Microneedle Drug Delivery Systems Market 2018 Segmentation, Demand, Growth, Trend, Opportunity and Forecast to 2023,” My News Desk, <https://www.mynewsdesk.com/se/probe-way/pressreleases/microneedle-drug-delivery-systems-market-2018-segmentation-demand-growth-trend-opportunity-and-forecast-to-2023-2672909> dated Sep. 3, 2018.Applicant
• Prokuski L. Prophylactic Antibiotics in Orthopaedic Surgery. JAAOS—Journal of the American Academy of Orthopaedic Surgeons. 2008; 16(5):283-293.Applicant
• Qian, Y. et al. Performance of N95 Respirators: Filtration Efficiency for Airborne Microbial and Inert Particles. American Industrial Hygiene Association Journal 1998, 59 (2), 128-132.Applicant
• Qiu, Y. et al. Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. Journal of Controlled Release 2008, 129, (2), 144-150.Applicant
• Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M: RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 2008, 32(1):150-158.Applicant
• Quinn, H. L. et al. Design of a dissolving microneedle platform for transdermal delivery of a fixed-dose combination of cardiovascular drugs. Journal of pharmaceutical sciences 2015, 104, (10), 3490-3500.Applicant
• Ratajska, M. et al. Studies on the Biodegradation of Chitosan in an Aqueous Medium. Fibres & Textiles in Eastern Europe 2003, (3 (42)), 75--79.Applicant
• Raynor, P. C. et al. The Long-Term Performance of Electrically Charged Filters in a Ventilation System. Journal of occupational and environmental hygiene 2004, 1 (7), 463-471.Applicant
• Resistance WHO-TICCIoA: No time to wait: Securing the future from drug-resistant infections. In.; 2019. 28 pages.Applicant
• Rigby KM, DeLeo FR: Neutrophils in innate host defense against Staphylococcus aureus infections. Semin Immunopathol 2012, 34(2):237-259.Applicant
• Riggin, C. N.; et al. Intra-articular tibiofemoral injection of a nonsteroidal anti-inflammatory drug has No. detrimental effects on joint mechanics in a rat model. Journal of Orthopaedic Research 2014, 32, (11), 1512-1519.Applicant
• Ripolin, A.; et al. Successful application of large microneedle patches by human volunteers. International journal of pharmaceutics 2017, 521, (1-2), 92-101.Applicant
• Rizzello L, et al. Nanotechnology tools for antibacterial materials. Nanomedicine (Lond). 2013;8(5):807-821.Applicant
• Roberts, M. S. et al. Percutaneous absorption of topically applied NSAIDS and other compounds: role of solute properties, skin physiology and delivery systems. Inflammopharmacology 1999, 7, (4), 339.Applicant
• Robertson JMC, et al. A comparison of the effectiveness of TiO2 photocatalysis and UVA photolysis for the destruction of three pathogenic micro-organisms. Journal of Photochemistry and Photobiology A: Chemistry. 2005;175(1):51-56.Applicant
• Rohrer, M. D. et al. Microwave Sterilization. Journal of the American Dental Association (1939) 1985, 110 (2), 194-198.Applicant
• Roy S, et al. Disposable Patterned Electroceutical Dressing (PED-10) Is Safe for Treatment of Open Clinical Chronic Wounds. Advances in Wound Care. 2019;8(4):149-159.Applicant
• Runyan CM, et al. Low-frequency ultrasound increases outer membrane permeability of Pseudomonas aeruginosa. The Journal of General and Applied Microbiology. 2006;52(5):295-301.Applicant
• Ruparelia JP, et al. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomater. 2008;4(3):707-716.Applicant
• Russell, R., Non-steroidal anti-inflammatory drugs and gastrointestinal damage—problems and solutions. Postgraduate medical journal 2001, 77, (904), 82-88.Applicant
• Sadorsky, P., The Effect of Urbanization and Industrialization on Energy Use in Emerging Economies: Implications for Sustainable Development. American Journal of Economics and Sociology 2014, 73 (2), 392-409.Applicant
• Salomonir R, et al. Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa. Nanotechnol Sci Appl. 2017;10:115-121.Applicant
• Santora, M. et al. Covid Updates: Known Global Tool Reaches 200 Millions Virus Infections. Aug. 4, 2021. https://web.archive.org/web/20210804234532/https://www.nytimes.com/live/2021/08/04/world/covid-delta-variant-vaccine (21 pages).Applicant
• Schlesinger, E. et al. Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design. Materials Science and Engineering: C 2015, 57, 232-239.Applicant
• Schlesinger, E.; et al. A tunable, biodegradable, thin-film polymer device as a long-acting implant delivering tenofovir alafenamide fumarate for HIV pre-exposure prophylaxis. Pharmaceutical research 2016, 33, (7), 1649-1656.Applicant
• Schmook, F. P.; et al. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. International journal of pharmaceutics 2001, 215, (1-2), 51-56.Applicant
• Schutze GE, Hall MA, Baker CJ, Edwards MS: Role of neutrophil receptors in opsonophagocytosis of coagulase-negative staphylococci. Infect Immun 1991, 59(8):2573-2578.Applicant
• Sencadas et al., Local piezoelectric activity of single poly(L-lactic acid) (PLLA) microfibers. Appl. Phys. A 109, 51-55 (2012).Applicant
• Seth AK, et al. Noncontact, low-frequency ultrasound as an effective therapy against Pseudomonas aeruginosa-infected biofilm wounds. Wound Repair Regen. 2013;21(2):266-274.Applicant
• Shah SR, et al. Evolving strategies for preventing biofilm on implantable materials. Materials Today. 2013;16(5):177-182.Applicant
• Shah, S.; et al. Controversies and advances in non-steroidal anti-inflammatory drug (NSAID) analgesia in chronic pain management. Postgraduate medical journal 2012, 88, (1036), 73-78.Applicant
• Shalumon KT, et al. Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int J Biol Macromol. 2011;49(3):247-254.Applicant
• Sheets, D.; et al. An Apparatus for Rapid and Nondestructive Comparison of Masks and Respirators. Review of Scientific Instruments 2020, 91 (11), 114101.Applicant
• Shim, J.-H. et al. Efficacy of rhBMP-2 loaded PCL/PLGA/β-TCP guided bone regeneration membrane fabricated by 3D printing technology for reconstruction of calvaria defects in rabbit. Biomedical materials 9, 065006 (2014) (9 pages).Applicant
• Shokri, J.; et al. Swellable elementary osmotic pump (SEOP): an effective device for delivery of poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics 2008, 68, (2), 289-297.Applicant
• Shrivastava S, et al. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology. 2007;18(22):225103 (9 pages).Applicant
• Shuai et al., “Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold,” Materials Science and Engineering: C, vol. 108, Mar. 2020, 110486.Applicant
• Shuai, C. et al. nMgO-incorporated PLLA bone scaffolds: Enhanced crystallinity and neutralized acidic products. Materials & Design 174, 107801 (2019).Applicant
• Silva, E.; et al. Pdlla Honeycomb-Like Scaffolds with a High Loading of Superhydrophilic Graphene/Multi-Walled Carbon Nanotubes Promote Osteoblast in Vitro Functions and Guided in Vivo Bone Regeneration. Materials Science and Engineering: C 2017, 73, 31-39.Applicant
• Sinatra, R. S.; et al. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology: The Journal of the American Society of Anesthesiologists 2005, 102, (4), 822-831.Applicant
• Smith et al. Direct observation of shear piezoelectricity in poly-L-lactic acid nanowires. APL Mater. 5, 074105 (2017) (8 pages).Applicant
• Starr MB, et al. Coupling of piezoelectric effect with electrochemical processes. Nano Energy. 2015; 14:296-311.Applicant
• Stokes, A.; et al. The contribution of obesity to prescription opioid use in the United States. Pain 2019, 160, (10), 2255.Applicant
• Subbiahdoss G, et al. Magnetic targeting of surface-modified superparamagnetic iron oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci. Acta Biomater. 2012;8(6):2047-2055.Applicant
• Sultana et al., Human skin interactive self-powered wearable piezoelectric bio-eskin by electrospun poly-L-lactic acid nanofibers for non-invasive physiological signal monitoring. J. Mater. Chem. B 5, 7352-7359 (2017).Applicant
• Sutton et al., “Hospital-, Health Care-, and Community-Acquired MRSA: Estimates From California Hospitals, 2013,” <https://www.hcup-us.ahrq.gov/reports/statbriefs/sb212-MRSA-Hospital-Stays-California-2013.jsp> dated Oct. 2016.Applicant
• Szablowski, et al. Acoustically targeted chemogenetics for the non-invasive control of neural circuits. Nat. Biomed. Eng. 2, 475-484 (2018).Applicant
• Taguchi, V. et al. Determination of drug stability in aspirin tablet formulations by high-pressure liquid chromatography. Journal of pharmaceutical sciences 1981, 70, (1), 64-67.Applicant
• Tajitsu et al. Novel tweezers for biological cells using piezoelectric polylactic acid fibers. Ferroelectrics 320, 133-139 (2005).Applicant
• Tajitsu, Y. Fundamental study on improvement of piezoelectricity of poly(ι-lactic acid) and its application to film actuators. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60, 1625-1629 (2013).Applicant
• Takeuchi, H.; et al. Influence of skin thickness on the in vitro permeabilities of drugs through Sprague-Dawley rat or Yucatan micropig skin. Biological and Pharmaceutical Bulletin 2012, 35, (2), 192-202.Applicant
• Tams J, et al. Poly(l-lactide) bone plates and screws for internal fixation of mandibular swing osteotomies. Int J Oral Maxillofac Surg. 1996;25(1):20-24.Applicant
• Tan, et al. Studies on Thermal Decomposition Mechanism and Kinetics of Aspirin [J]. Acta Physico-chimica Sinica 2004, 1m 50-54. With English Abstract.Applicant
• Tan, G., et al. “Surface-selective preferential production of reactive oxygen species on piezoelectric ceramics for bacterial killing.” ACS applied materials & interfaces 8.37 (2016): 24306-24309.Applicant
• Tao H, et al. Silk-based resorbable electronic devices for remotely controlled therapy and in vivo infection abatement. Proceedings of the National Academy of Sciences. 2014;111(49):17385.Applicant
• Tezel A, et al. Topical Delivery of Anti-sense Oligonucleotides Using Low-Frequency Sonophoresis. Pharm Res. 2004;21(12):2219-2225.Applicant
• Thakur, R. R. S.; et al. Microneedle-mediated intrascleral delivery of in situ forming thermoresponsive implants for sustained ocular drug delivery. Journal of Pharmacy and Pharmacology 2014, 66, (4), 584-595.Applicant
• Thamma Vongsa V, Kim HK, Missiakas D, Schneewind O: Staphylococcal manipulation of host immune responses. Nat Rev Microbiol 2015, 13(9):529-543.Applicant
• Thermofisher Scientific. Residual Solvent Analysis Information. Jul. 14, 2019. https://web.archive.org/web/20190714025617/https://www.thermofisher.com/us/en/home/industrial/pharma-biopharma/pharma-biopharma-learning-center/pharmaceutical-qa-qc-information/residual-solvent-analysis-information.html (6 pages).Applicant
• Timin, A. S., et al. “Multifunctional scaffolds with improved antimicrobial properties and osteogenicity based on piezoelectric electrospun fibers decorated with bioactive composite microcapsules.” ACS applied materials & interfaces 10.41 (2018): 34849-34868.Applicant
• Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG, Jr.: Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 2015, 28(3):603-661.Applicant
• Tran, K. T.; et al. Lithography-based methods to manufacture biomaterials at small scales. Journal of Science: Advanced Materials and Devices 2017, 2, (1), 1-14.Applicant
• Tucho, G. T.; et al., Universal Use of Face Masks and Related Challenges During Covid-19 in Developing Countries. Risk Management and Healthcare Policy 2021, 14, 511.Applicant
• Ueki, H.; et al. Effectiveness of Face Masks in Preventing Airborne Transmission of Sars-Cov-2. MSphere 2020, 5 (5), e00637-20.Applicant
• Ummadi, S.; et al. Overview on controlled release dosage form. System 2013, 7, (8), 51-60.Applicant
• Valentini, R. F., et al. Electrically charged polymeric substrates enhance nerve fibre outgrowth in vitro. Biomaterials 13, 183-190 (1992).Applicant
• Van Acker H, et al. The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria. Trends in Microbiology. 2017;25(6):456-466.Applicant
• Varrone JJ, et al. Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters. J Orthop Res 2014, 32(10):1389-1396.Applicant
• Varrone JJ, Li D, Daiss JL, Schwarz EM: Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections. Bonekey Osteovision 2011, 8:187-194.Applicant
• Vykhodtseva, et al. Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Ultrasonics 48, 279-296 (2008).Applicant
• Vysakh et al., “A Comparative Analysis of Community Acquired and Hospital Acquired Methicillin Resistant Staphylococcus aureus,” J Clin Diagn Res. Jul. 2013; 7(7): 1339-1342.Applicant
• Walmsley, A. et al. Ultrasound in dentistry. Part 2—periodontology and endodontics. J. Dent. 20, 11-17 (1992).Applicant
• Walsh C. Molecular mechanisms that confer antibacterial drug resistance. Nature. 2000;406(6797):775-781.Applicant
• Wang F, Gao W, Thamphiwatana S, Luk BT, Angsantikul P, Zhang Q, Hu CM, Fang RH, Copp JA, Pornpattananangkul D et al: Hydrogel Retaining Toxin-Absorbing Nanosponges for Local Treatment of Methicillin-Resistant Staphylococcus aureus Infection. Adv Mater 2015, 27(22):3437-3443.Applicant
• Wang Y, et al. Piezo-catalysis for nondestructive tooth whitening. Nature Communications. 2020;11(1):1328.Applicant
• Wang, C. et al. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of anti-PD1 antibody. Nano letters 2016, 16, (4), 2334-2340.Applicant
• Wang, C. et al. Silk Nanofibers as High Efficient and Lightweight Air Filter. Nano Research 2016, 9 (9), 2590-2597.Applicant
• Wang, N. et al. Tunable Fabrication of Three-Dimensional Polyamide-66 Nano-Fiber/Nets for High Efficiency Fine Particulate Filtration. Journal of Materials Chemistry 2012, 22 (4), 1445-1452.Applicant
• Wang, P. et al. Ultrasmall Barium Titanate Nanoparticles for Highly Efficient Hypoxic Tumor Therapy Via Ultrasound Triggered Piezocatalysis and Water Splitting. ACS nano 2021, 11326-11340.Applicant
• Wang, S. et al. Controlled release of levonorgestrel from biodegradable poly (D, L-lactide-co-glycolide) microspheres: in vitro and in vivo studies. International journal of pharmaceutics 2005, 301, (1-2), 217-225.Applicant
• Wang, S. et al. Electret Polyvinylidene Fluoride Nanofibers Hybridized by Polytetrafluoroethylene Nanoparticles for High-Efficiency Air Filtration. ACS applied materials & interfaces 2016, 8 (36), 23985-23994.Applicant
• Wang, Z. et al. Porous Bead-on-String Poly (Lactic Acid) Fibrous Membranes for Air Filtration. Journal of colloid and interface science 2015, 441, 121-129.Applicant
• Wang, Z.-F. et al. Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats. Neuroscience 2014, 273, 65-78.Applicant
• Ward AR, et al. Comparison of Heating of Nonliving Soft Tissue produced by 45 kHz and 1 MHz Frequency Ultrasound Machines. J Orthop Sports Phys Ther. 1996;23(4):258-266.Applicant
• Wartzek, et al. Triboelectricity in capacitive biopotential measurements. IEEE Trans. Biomed. Eng. 58, 1268-1277 (2011).Applicant
• WHO, “New report calls for urgent action to avert antimicrobial resistance crisis,” <https://www.who.int/news/item/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis> dated Apr. 29, 2019.Applicant
• WHO. Coronavirus Disease (Covid-19) Advice for the Public: When and How to Use Masks. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/when-andhow-to-use-masks (Updated Dec. 2021) (12 pages).Applicant
• WHO. Shortage of Personal Protective Equipment Endangering Health Workers Worldwide. https://www.who.int/news/item/03-03-2020-shortage-of-personal-protective-equipment-endangering-health-workers-worldwide. Mar. 3, 2020 (3 pages).Applicant
• Wiese, A. D.; et al. Opioid analgesics and the risk of serious infections among patients with rheumatoid arthritis: a self-controlled case series study. Arthritis & rheumatology 2016, 68, (2), 323-331.Applicant
• Witzleb et al. Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty. Acta Orthop. 77, 697-705 (2006).Applicant
• Woltjer et al. (2016) “Optimization of piezo-MEMS layout for a bladder monitor” in 2016 IEEE International Ultrasonics Symposium (IUS) (IEEE, 2016), pp. 1-4.Applicant
• Wu, S. et al. Surface Modification of Pure Magnesium Mesh for Guided Bone Regeneration: In Vivo Evaluation of Rat Calvarial Defect. Materials 12, 2684 (2019).Applicant
• Wynn, R. F. et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 104, 2643-2645 (2004).Applicant
• Xin et al., A Site-Specific Integrated Col2. 3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells. Stem cells translational medicine 3, 1125-1137 (2014).Applicant
• Xiong, Z.-C. et al. Flexible Hydroxyapatite Ultralong Nanowire-Based Paper for Highly Efficient and Multifunctional Air Filtration. Journal of Materials Chemistry A 2017, 5 (33), 17482-17491.Applicant
• Xu X, et al. Strong vibration-catalysis of ZnO nanorods for dye wastewater decolorization via piezo-electro-chemical coupling. Chemosphere. 2018;193:1143-1148.Applicant
• Xu, E. G.; et al.Preventing Masks from Becoming the Next Plastic Problem. Frontiers of environmental science & engineering 2021, 15 (6), 125.Applicant
• Yang, M.; et al. Is Pm1 Similar to Pm2. 5? A New Insight into the Association of Pm1 and Pm2. 5 with Children's Lung Function. Environment International 2020, 145, 106092.Applicant
• Yoshimoto, I. et al. Development of layered PLGA membranes for periodontal tissue regeneration. Dent. Mater. 34, 538-550, (2018).Applicant
• You H., et al. Strong piezo-electrochemical effect of multiferroic BiFeO3 square micro-sheets for mechanocatalysis. Electrochem Commun. 2017;79:55-58.Applicant
• Yu, J.; et al. Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs. Nature Biomedical Engineering 2020, 1-8.Applicant
• Yu, Y. et al. Multifunctions of dual Zn/Mg ion co-implanted titanium on osteogenesis, angiogenesis and bacteria inhibition for dental implants. Acta Biomater. 49, 590-603 (2017).Applicant
• Zhang, H. et al. Drug delivery systems for differential release in combination therapy. Expert opinion on drug delivery 2011, 8, (2), 171-190.Applicant
• Zhang, J. et al. Biodegradable Electrospun Poly (Lactic Acid) Nanofibers for Effective Pm 2.5 Removal. Macromolecular Materials and Engineering 2019, 304 (10), 1900259.Applicant
• Zhang, Q.; et al. Transboundary Health Impacts of Transported Global Air Pollution and International Trade. Nature 2017, 543 (7647), 705-709.Applicant
• Zhang, R. et al. Nanofiber Air Filters with High-Temperature Stability for Efficient Pm2. 5 Removal from the Pollution Sources. Nano letters 2016, 16 (6), 3642-3649.Applicant
• Zhang, S.; et al. Spider-Web-Inspired Pm0. 3 Filters Based on Self-Sustained Electrostatic Nanostructured Networks. Advanced Materials 2020, 32 (29), 2002361.Applicant
• Zhang, Y. et al. Preparation of Nanofibrous Metal-Organic Framework Filters for Efficient Air Pollution Control. Journal of the American Chemical Society 2016, 138 (18), 5785-5788.Applicant
• Zhao et al., Electrospun poly(L-lactic acid) nanofibers for nanogenerator and diagnostic sensor applications. Macromol. Mater. Eng. 302, 1600476 (2017).Applicant
• Zhou Y, Niu C, Ma B, Xue X, Li Z, Chen Z, Li F, Zhou S, Luo X, Hou Z: Inhibiting PSMalpha-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system. Cell Death Dis 2018, 9(3):362.Applicant
• Zhu X, et al. Nanomedicine in the management of microbial infection—Overview and perspectives. Nano Today. 2014;9(4):478-498.Applicant